Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 2924 | 1640 | None | 38 | Human | Functional | pEC50 | = | 10 | 10.0 | -10 | 7 | Activity at human S1P3 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P3 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1016/j.bmc.2006.10.060 | ||
| 44398069 | 1640 | None | 38 | Human | Functional | pEC50 | = | 10 | 10.0 | -10 | 7 | Activity at human S1P3 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P3 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1016/j.bmc.2006.10.060 | ||
| 9908268 | 1640 | None | 38 | Human | Functional | pEC50 | = | 10 | 10.0 | -10 | 7 | Activity at human S1P3 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P3 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1016/j.bmc.2006.10.060 | ||
| CHEMBL114606 | 1640 | None | 38 | Human | Functional | pEC50 | = | 10 | 10.0 | -10 | 7 | Activity at human S1P3 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P3 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1016/j.bmc.2006.10.060 | ||
| 11452022 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -19 | 6 | Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayAgonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1016/j.bmcl.2010.02.006 | ||
| 6996 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -19 | 6 | Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayAgonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1016/j.bmcl.2010.02.006 | ||
| CHEMBL366208 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -19 | 6 | Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayAgonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1016/j.bmcl.2010.02.006 | ||
| 25192005 | 7738 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | -3 | 2 | Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayAgonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay |
ChEMBL | 397 | 11 | 3 | 3 | 4.5 | CCCCCCCCc1ccc2c(c1)CC[C@@H]([C@@](C)(N)COP(=O)(O)O)C2 | 10.1016/j.bmcl.2010.02.006 | ||
| CHEMBL1089004 | 7738 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | -3 | 2 | Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayAgonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay |
ChEMBL | 397 | 11 | 3 | 3 | 4.5 | CCCCCCCCc1ccc2c(c1)CC[C@@H]([C@@](C)(N)COP(=O)(O)O)C2 | 10.1016/j.bmcl.2010.02.006 | ||
| 44406004 | 72740 | None | 10 | Human | Functional | pEC50 | = | 9.8 | 9.8 | 5 | 4 | Binding potency at human S1P3 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P3 receptor by [35S]GTP-gamma-S binding assay |
ChEMBL | 337 | 14 | 4 | 4 | 2.9 | CCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(=O)(O)O | 10.1016/j.bmcl.2005.09.038 | ||
| CHEMBL199791 | 72740 | None | 10 | Human | Functional | pEC50 | = | 9.8 | 9.8 | 5 | 4 | Binding potency at human S1P3 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P3 receptor by [35S]GTP-gamma-S binding assay |
ChEMBL | 337 | 14 | 4 | 4 | 2.9 | CCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(=O)(O)O | 10.1016/j.bmcl.2005.09.038 | ||
| 25192001 | 8061 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -2 | 4 | Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayAgonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay |
ChEMBL | 413 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc2c(c1)CC[C@@H](C(N)(CO)COP(=O)(O)O)C2 | 10.1016/j.bmcl.2010.02.006 | ||
| CHEMBL1091103 | 8061 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -2 | 4 | Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayAgonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay |
ChEMBL | 413 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc2c(c1)CC[C@@H](C(N)(CO)COP(=O)(O)O)C2 | 10.1016/j.bmcl.2010.02.006 | ||
| 46884020 | 8442 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -30 | 4 | Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayAgonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay |
ChEMBL | 397 | 11 | 3 | 3 | 4.5 | CCCCCCCCc1ccc2c(c1)CC[C@H]([C@@](C)(N)COP(=O)(O)O)C2 | 10.1016/j.bmcl.2010.02.006 | ||
| CHEMBL1093686 | 8442 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -30 | 4 | Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayAgonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay |
ChEMBL | 397 | 11 | 3 | 3 | 4.5 | CCCCCCCCc1ccc2c(c1)CC[C@H]([C@@](C)(N)COP(=O)(O)O)C2 | 10.1016/j.bmcl.2010.02.006 | ||
| 10883396 | 3649 | None | 30 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -1 | 15 | Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayAgonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2010.02.006 | ||
| 5283560 | 3649 | None | 30 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -1 | 15 | Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayAgonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2010.02.006 | ||
| 911 | 3649 | None | 30 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -1 | 15 | Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayAgonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2010.02.006 | ||
| CHEMBL225155 | 3649 | None | 30 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -1 | 15 | Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayAgonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2010.02.006 | ||
| 10883396 | 3649 | None | 30 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -1 | 15 | Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assayAgonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assay |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | ||
| 5283560 | 3649 | None | 30 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -1 | 15 | Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assayAgonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assay |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | ||
| 911 | 3649 | None | 30 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -1 | 15 | Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assayAgonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assay |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | ||
| CHEMBL225155 | 3649 | None | 30 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -1 | 15 | Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assayAgonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assay |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | ||
| 76332615 | 105610 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 5 | 2 | Agonist activity at human recombinant S1P3 receptor expressed in CHO cells assessed as membrane-bound 35S-GTPgammaS incubated 30 mins prior to substrate addition measured after 1 hr by topcount scintillation counting analysisAgonist activity at human recombinant S1P3 receptor expressed in CHO cells assessed as membrane-bound 35S-GTPgammaS incubated 30 mins prior to substrate addition measured after 1 hr by topcount scintillation counting analysis |
ChEMBL | 555 | 12 | 3 | 8 | 5.0 | CCc1cc(-c2noc(-c3sc(CC)c4c3CCC(CC)(CC)C4)n2)cc(C)c1OC[C@@H](O)CNC(=O)CO | 10.1021/jm401456d | ||
| CHEMBL3121986 | 105610 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 5 | 2 | Agonist activity at human recombinant S1P3 receptor expressed in CHO cells assessed as membrane-bound 35S-GTPgammaS incubated 30 mins prior to substrate addition measured after 1 hr by topcount scintillation counting analysisAgonist activity at human recombinant S1P3 receptor expressed in CHO cells assessed as membrane-bound 35S-GTPgammaS incubated 30 mins prior to substrate addition measured after 1 hr by topcount scintillation counting analysis |
ChEMBL | 555 | 12 | 3 | 8 | 5.0 | CCc1cc(-c2noc(-c3sc(CC)c4c3CCC(CC)(CC)C4)n2)cc(C)c1OC[C@@H](O)CNC(=O)CO | 10.1021/jm401456d | ||
| 44565714 | 179403 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -6 | 4 | Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS binding |
ChEMBL | 484 | 11 | 4 | 5 | 4.1 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCc2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2009.02.073 | ||
| CHEMBL473238 | 179403 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -6 | 4 | Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS binding |
ChEMBL | 484 | 11 | 4 | 5 | 4.1 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCc2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2009.02.073 | ||
| 2924 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -10 | 7 | Agonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/jm050242f | ||
| 44398069 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -10 | 7 | Agonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/jm050242f | ||
| 9908268 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -10 | 7 | Agonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/jm050242f | ||
| CHEMBL114606 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -10 | 7 | Agonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/jm050242f | ||
| 44218130 | 139977 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -1 | 2 | Agonist activity at human recombinant S1PR3 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount analysisAgonist activity at human recombinant S1PR3 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount analysis |
ChEMBL | 552 | 14 | 3 | 8 | 4.3 | CCc1cc(-c2noc(-c3cc(CN(C)CC(C)C)cc(C(C)C)c3)n2)cc(C)c1OC[C@@H](O)CNC(=O)CO | 10.1016/j.ejmech.2016.03.048 | ||
| CHEMBL3799355 | 139977 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -1 | 2 | Agonist activity at human recombinant S1PR3 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount analysisAgonist activity at human recombinant S1PR3 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount analysis |
ChEMBL | 552 | 14 | 3 | 8 | 4.3 | CCc1cc(-c2noc(-c3cc(CN(C)CC(C)C)cc(C(C)C)c3)n2)cc(C)c1OC[C@@H](O)CNC(=O)CO | 10.1016/j.ejmech.2016.03.048 | ||
| 10883396 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -1 | 15 | Activity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2006.10.014 | ||
| 5283560 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -1 | 15 | Activity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2006.10.014 | ||
| 911 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -1 | 15 | Activity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2006.10.014 | ||
| CHEMBL225155 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -1 | 15 | Activity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2006.10.014 | ||
| 11222939 | 67596 | None | 8 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -4 | 4 | Activity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2006.10.014 | ||
| 44438254 | 67596 | None | 8 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -4 | 4 | Activity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2006.10.014 | ||
| CHEMBL190006 | 67596 | None | 8 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -4 | 4 | Activity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2006.10.014 | ||
| 44591250 | 189863 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | -19 | 4 | Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS binding |
ChEMBL | 420 | 13 | 4 | 5 | 3.3 | CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)cc1F | 10.1016/j.bmcl.2008.11.072 | ||
| CHEMBL515921 | 189863 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | -19 | 4 | Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS binding |
ChEMBL | 420 | 13 | 4 | 5 | 3.3 | CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)cc1F | 10.1016/j.bmcl.2008.11.072 | ||
| 44591266 | 179406 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -19 | 4 | Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS binding |
ChEMBL | 443 | 13 | 4 | 5 | 4.2 | CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1F | 10.1016/j.bmcl.2008.11.072 | ||
| CHEMBL473269 | 179406 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -19 | 4 | Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS binding |
ChEMBL | 443 | 13 | 4 | 5 | 4.2 | CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1F | 10.1016/j.bmcl.2008.11.072 | ||
| 44422606 | 85607 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -2 | 5 | Activity at human S1P3 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P3 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay |
ChEMBL | 329 | 11 | 3 | 3 | 3.1 | CCCCCCc1ccc(OC[C@H](N)CCP(=O)(O)O)cc1 | 10.1016/j.bmc.2006.10.060 | ||
| CHEMBL228049 | 85607 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -2 | 5 | Activity at human S1P3 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P3 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay |
ChEMBL | 329 | 11 | 3 | 3 | 3.1 | CCCCCCc1ccc(OC[C@H](N)CCP(=O)(O)O)cc1 | 10.1016/j.bmc.2006.10.060 | ||
| 44219525 | 140029 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -47 | 2 | Agonist activity at human recombinant S1PR3 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount analysisAgonist activity at human recombinant S1PR3 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount analysis |
ChEMBL | 524 | 13 | 3 | 8 | 3.5 | CCc1cc(-c2noc(-c3cc(C)cc(CN(C)CC(C)C)c3)n2)cc(C)c1OC[C@@H](O)CNC(=O)CO | 10.1016/j.ejmech.2016.03.048 | ||
| CHEMBL3799686 | 140029 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -47 | 2 | Agonist activity at human recombinant S1PR3 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount analysisAgonist activity at human recombinant S1PR3 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount analysis |
ChEMBL | 524 | 13 | 3 | 8 | 3.5 | CCc1cc(-c2noc(-c3cc(C)cc(CN(C)CC(C)C)c3)n2)cc(C)c1OC[C@@H](O)CNC(=O)CO | 10.1016/j.ejmech.2016.03.048 | ||
| 44218450 | 140036 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -100 | 2 | Agonist activity at human recombinant S1PR3 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount analysisAgonist activity at human recombinant S1PR3 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount analysis |
ChEMBL | 510 | 13 | 3 | 8 | 3.1 | CCc1cc(-c2nc(-c3cc(C)c(OC[C@@H](O)CNC(=O)CO)c(CC)c3)no2)ccc1CN(C)CC | 10.1016/j.ejmech.2016.03.048 | ||
| CHEMBL3799718 | 140036 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -100 | 2 | Agonist activity at human recombinant S1PR3 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount analysisAgonist activity at human recombinant S1PR3 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount analysis |
ChEMBL | 510 | 13 | 3 | 8 | 3.1 | CCc1cc(-c2nc(-c3cc(C)c(OC[C@@H](O)CNC(=O)CO)c(CC)c3)no2)ccc1CN(C)CC | 10.1016/j.ejmech.2016.03.048 | ||
Showing 1 to 50 of 1,686 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 10883396 | 3649 | None | 30 | Human | Binding | pEC50 | = | 9.7 | 9.7 | -1 | 4 | Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation counting |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | ||
| 5283560 | 3649 | None | 30 | Human | Binding | pEC50 | = | 9.7 | 9.7 | -1 | 4 | Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation counting |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | ||
| 911 | 3649 | None | 30 | Human | Binding | pEC50 | = | 9.7 | 9.7 | -1 | 4 | Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation counting |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | ||
| CHEMBL225155 | 3649 | None | 30 | Human | Binding | pEC50 | = | 9.7 | 9.7 | -1 | 4 | Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation counting |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | ||
| 10883396 | 3649 | None | 30 | Human | Binding | pEC50 | = | 9.0 | 9.0 | -1 | 4 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1) |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | ||
| 5283560 | 3649 | None | 30 | Human | Binding | pEC50 | = | 9.0 | 9.0 | -1 | 4 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1) |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | ||
| 911 | 3649 | None | 30 | Human | Binding | pEC50 | = | 9.0 | 9.0 | -1 | 4 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1) |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | ||
| CHEMBL225155 | 3649 | None | 30 | Human | Binding | pEC50 | = | 9.0 | 9.0 | -1 | 4 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1) |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | ||
| 10883396 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.9 | 8.9 | -1 | 4 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.07.030 | ||
| 5283560 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.9 | 8.9 | -1 | 4 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.07.030 | ||
| 911 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.9 | 8.9 | -1 | 4 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.07.030 | ||
| CHEMBL225155 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.9 | 8.9 | -1 | 4 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.07.030 | ||
| 49839234 | 118015 | None | 0 | Human | Binding | pEC50 | = | 5 | 5.0 | - | 0 | Agonist activity at human S1P3 receptor by beta-arrestin recruitment assayAgonist activity at human S1P3 receptor by beta-arrestin recruitment assay |
ChEMBL | 472 | 6 | 3 | 3 | 6.1 | O=C(O)CC1NCCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)cc21 | 10.1016/j.bmcl.2014.11.089 | ||
| CHEMBL3403619 | 118015 | None | 0 | Human | Binding | pEC50 | = | 5 | 5.0 | - | 0 | Agonist activity at human S1P3 receptor by beta-arrestin recruitment assayAgonist activity at human S1P3 receptor by beta-arrestin recruitment assay |
ChEMBL | 472 | 6 | 3 | 3 | 6.1 | O=C(O)CC1NCCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)cc21 | 10.1016/j.bmcl.2014.11.089 | ||
| 25110488 | 72009 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human S1P3 receptor expressed in CHO cells after 4 hrs by fluorescence assayAgonist activity at human S1P3 receptor expressed in CHO cells after 4 hrs by fluorescence assay |
ChEMBL | 352 | 4 | 0 | 3 | 5.4 | O=C(c1cc(-c2ccccc2)on1)N(C1CCCCC1)C1CCCCC1 | 10.1016/j.bmcl.2013.09.075 | ||
| CHEMBL1973788 | 72009 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human S1P3 receptor expressed in CHO cells after 4 hrs by fluorescence assayAgonist activity at human S1P3 receptor expressed in CHO cells after 4 hrs by fluorescence assay |
ChEMBL | 352 | 4 | 0 | 3 | 5.4 | O=C(c1cc(-c2ccccc2)on1)N(C1CCCCC1)C1CCCCC1 | 10.1016/j.bmcl.2013.09.075 | ||
| 17253208 | 1299 | None | 40 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human S1P3 receptor expressed in CHO cells after 4 hrs by fluorescence assayAgonist activity at human S1P3 receptor expressed in CHO cells after 4 hrs by fluorescence assay |
ChEMBL | 316 | 4 | 0 | 3 | 4.7 | O=C(N(C1CCCCC1)C1CCCCC1)c1noc(c1)C1CC1 | 10.1016/j.bmcl.2013.09.075 | ||
| 9494 | 1299 | None | 40 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human S1P3 receptor expressed in CHO cells after 4 hrs by fluorescence assayAgonist activity at human S1P3 receptor expressed in CHO cells after 4 hrs by fluorescence assay |
ChEMBL | 316 | 4 | 0 | 3 | 4.7 | O=C(N(C1CCCCC1)C1CCCCC1)c1noc(c1)C1CC1 | 10.1016/j.bmcl.2013.09.075 | ||
| CHEMBL1970071 | 1299 | None | 40 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human S1P3 receptor expressed in CHO cells after 4 hrs by fluorescence assayAgonist activity at human S1P3 receptor expressed in CHO cells after 4 hrs by fluorescence assay |
ChEMBL | 316 | 4 | 0 | 3 | 4.7 | O=C(N(C1CCCCC1)C1CCCCC1)c1noc(c1)C1CC1 | 10.1016/j.bmcl.2013.09.075 | ||
| 127031187 | 138969 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at S1P3 receptor (unknown origin) expressed in CHO cells incubated for 2 hrs by HTRF-IP1 assayAgonist activity at S1P3 receptor (unknown origin) expressed in CHO cells incubated for 2 hrs by HTRF-IP1 assay |
ChEMBL | 446 | 10 | 4 | 6 | 3.3 | CCc1nc(-c2ccc(-c3ccc(CCC(N)(CO)COP(=O)(O)O)cc3)cc2)co1 | 10.1016/j.bmc.2016.03.059 | ||
| CHEMBL3781008 | 138969 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at S1P3 receptor (unknown origin) expressed in CHO cells incubated for 2 hrs by HTRF-IP1 assayAgonist activity at S1P3 receptor (unknown origin) expressed in CHO cells incubated for 2 hrs by HTRF-IP1 assay |
ChEMBL | 446 | 10 | 4 | 6 | 3.3 | CCc1nc(-c2ccc(-c3ccc(CCC(N)(CO)COP(=O)(O)O)cc3)cc2)co1 | 10.1016/j.bmc.2016.03.059 | ||
| CHEMBL3782062 | 138969 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at S1P3 receptor (unknown origin) expressed in CHO cells incubated for 2 hrs by HTRF-IP1 assayAgonist activity at S1P3 receptor (unknown origin) expressed in CHO cells incubated for 2 hrs by HTRF-IP1 assay |
ChEMBL | 446 | 10 | 4 | 6 | 3.3 | CCc1nc(-c2ccc(-c3ccc(CCC(N)(CO)COP(=O)(O)O)cc3)cc2)co1 | 10.1016/j.bmc.2016.03.059 | ||
| 67169586 | 182444 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 486 | 6 | 1 | 5 | 5.4 | CC(C)Oc1ccc(-c2onc3c2CCc2cc(CN4CC(C(=O)O)C4)ccc2-3)c(C(F)(F)F)c1 | 10.1021/acs.jmedchem.6b01099 | ||
| CHEMBL4784466 | 182444 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 486 | 6 | 1 | 5 | 5.4 | CC(C)Oc1ccc(-c2onc3c2CCc2cc(CN4CC(C(=O)O)C4)ccc2-3)c(C(F)(F)F)c1 | 10.1021/acs.jmedchem.6b01099 | ||
| 76325531 | 105813 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at human recombinant S1P3 receptor expressed in CHO cells incubated for 30 mins prior to 35SGTP-gammaS addition measured after 1 hr by 35SGTP-gammaS binding assayAgonist activity at human recombinant S1P3 receptor expressed in CHO cells incubated for 30 mins prior to 35SGTP-gammaS addition measured after 1 hr by 35SGTP-gammaS binding assay |
ChEMBL | 454 | 11 | 3 | 8 | 2.5 | CCCc1cc(-c2nc(-c3cc(C)c(OC[C@@H](O)CNC(=O)CO)c(CC)c3)no2)ccn1 | 10.1021/ml500484v | ||
| CHEMBL3126602 | 105813 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at human recombinant S1P3 receptor expressed in CHO cells incubated for 30 mins prior to 35SGTP-gammaS addition measured after 1 hr by 35SGTP-gammaS binding assayAgonist activity at human recombinant S1P3 receptor expressed in CHO cells incubated for 30 mins prior to 35SGTP-gammaS addition measured after 1 hr by 35SGTP-gammaS binding assay |
ChEMBL | 454 | 11 | 3 | 8 | 2.5 | CCCc1cc(-c2nc(-c3cc(C)c(OC[C@@H](O)CNC(=O)CO)c(CC)c3)no2)ccn1 | 10.1021/ml500484v | ||
| 67168053 | 180953 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 497 | 5 | 1 | 7 | 5.1 | O=C(O)C1CN(Cc2ccc3c(c2)OCc2c-3noc2-c2noc(-c3ccccc3)c2C(F)(F)F)C1 | 10.1021/acs.jmedchem.6b01099 | ||
| CHEMBL4757149 | 180953 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 497 | 5 | 1 | 7 | 5.1 | O=C(O)C1CN(Cc2ccc3c(c2)OCc2c-3noc2-c2noc(-c3ccccc3)c2C(F)(F)F)C1 | 10.1021/acs.jmedchem.6b01099 | ||
| 67169634 | 181099 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 509 | 5 | 1 | 6 | 5.6 | Cc1cc2c(cc1CN1CC(C(=O)O)C1)CCc1c-2noc1-c1noc(-c2ccccc2)c1C(F)(F)F | 10.1021/acs.jmedchem.6b01099 | ||
| CHEMBL4758827 | 181099 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 509 | 5 | 1 | 6 | 5.6 | Cc1cc2c(cc1CN1CC(C(=O)O)C1)CCc1c-2noc1-c1noc(-c2ccccc2)c1C(F)(F)F | 10.1021/acs.jmedchem.6b01099 | ||
| 67170332 | 180779 | None | 0 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 511 | 5 | 1 | 6 | 5.8 | O=C(O)C1CN(Cc2ccc3c(c2)CCc2nc(-c4onc(-c5ccccc5)c4C(F)(F)F)sc2-3)C1 | 10.1021/acs.jmedchem.6b01099 | ||
| CHEMBL4755286 | 180779 | None | 0 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 511 | 5 | 1 | 6 | 5.8 | O=C(O)C1CN(Cc2ccc3c(c2)CCc2nc(-c4onc(-c5ccccc5)c4C(F)(F)F)sc2-3)C1 | 10.1021/acs.jmedchem.6b01099 | ||
| 162673462 | 183297 | None | 0 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 509 | 5 | 1 | 6 | 5.7 | O=C(O)C1CN(Cc2ccc3c(c2)CCCc2c(-c4noc(-c5ccccc5)c4C(F)(F)F)noc2-3)C1 | 10.1021/acs.jmedchem.6b01099 | ||
| CHEMBL4795734 | 183297 | None | 0 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 509 | 5 | 1 | 6 | 5.7 | O=C(O)C1CN(Cc2ccc3c(c2)CCCc2c(-c4noc(-c5ccccc5)c4C(F)(F)F)noc2-3)C1 | 10.1021/acs.jmedchem.6b01099 | ||
| 2924 | 1640 | None | 38 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at S1PR3 (unknown origin) by HTRF assayAgonist activity at S1PR3 (unknown origin) by HTRF assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1016/j.bmcl.2020.127141 | ||
| 44398069 | 1640 | None | 38 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at S1PR3 (unknown origin) by HTRF assayAgonist activity at S1PR3 (unknown origin) by HTRF assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1016/j.bmcl.2020.127141 | ||
| 9908268 | 1640 | None | 38 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at S1PR3 (unknown origin) by HTRF assayAgonist activity at S1PR3 (unknown origin) by HTRF assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1016/j.bmcl.2020.127141 | ||
| CHEMBL114606 | 1640 | None | 38 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at S1PR3 (unknown origin) by HTRF assayAgonist activity at S1PR3 (unknown origin) by HTRF assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1016/j.bmcl.2020.127141 | ||
| 53235408 | 180981 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 473 | 5 | 1 | 6 | 4.7 | CC1(c2onc(-c3onc4c3CCc3cc(CN5CC(C(=O)O)C5)ccc3-4)c2C(F)(F)F)CC1 | 10.1021/acs.jmedchem.6b01099 | ||
| CHEMBL4757437 | 180981 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 473 | 5 | 1 | 6 | 4.7 | CC1(c2onc(-c3onc4c3CCc3cc(CN5CC(C(=O)O)C5)ccc3-4)c2C(F)(F)F)CC1 | 10.1021/acs.jmedchem.6b01099 | ||
| 67171369 | 181797 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 496 | 5 | 1 | 7 | 4.7 | O=C(O)C1CN(Cc2ccc3c(c2)CCc2c-3noc2-c2onc(-c3ccccn3)c2C(F)(F)F)C1 | 10.1021/acs.jmedchem.6b01099 | ||
| CHEMBL4776597 | 181797 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 496 | 5 | 1 | 7 | 4.7 | O=C(O)C1CN(Cc2ccc3c(c2)CCc2c-3noc2-c2onc(-c3ccccn3)c2C(F)(F)F)C1 | 10.1021/acs.jmedchem.6b01099 | ||
| 162660222 | 181335 | None | 0 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 553 | 6 | 2 | 7 | 5.6 | O=C(O)[C@H]1CCCN(CC(O)c2ccc3c(c2)CCc2c(-c4noc(-c5ccccc5)c4C(F)(F)F)noc2-3)C1 | 10.1021/acs.jmedchem.6b01099 | ||
| CHEMBL4761456 | 181335 | None | 0 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 553 | 6 | 2 | 7 | 5.6 | O=C(O)[C@H]1CCCN(CC(O)c2ccc3c(c2)CCc2c(-c4noc(-c5ccccc5)c4C(F)(F)F)noc2-3)C1 | 10.1021/acs.jmedchem.6b01099 | ||
| 76321895 | 105818 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human recombinant S1P3 receptor expressed in CHO cells incubated for 30 mins prior to 35SGTP-gammaS addition measured after 1 hr by 35SGTP-gammaS binding assayAgonist activity at human recombinant S1P3 receptor expressed in CHO cells incubated for 30 mins prior to 35SGTP-gammaS addition measured after 1 hr by 35SGTP-gammaS binding assay |
ChEMBL | 482 | 12 | 3 | 8 | 3.4 | CCc1cc(-c2noc(-c3ccnc(C(CC)CC)c3)n2)cc(C)c1OC[C@@H](O)CNC(=O)CO | 10.1021/ml500484v | ||
| CHEMBL3126607 | 105818 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human recombinant S1P3 receptor expressed in CHO cells incubated for 30 mins prior to 35SGTP-gammaS addition measured after 1 hr by 35SGTP-gammaS binding assayAgonist activity at human recombinant S1P3 receptor expressed in CHO cells incubated for 30 mins prior to 35SGTP-gammaS addition measured after 1 hr by 35SGTP-gammaS binding assay |
ChEMBL | 482 | 12 | 3 | 8 | 3.4 | CCc1cc(-c2noc(-c3ccnc(C(CC)CC)c3)n2)cc(C)c1OC[C@@H](O)CNC(=O)CO | 10.1021/ml500484v | ||
| 25110485 | 72788 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human S1P3 receptor expressed in CHO cells after 4 hrs by fluorescence assayAgonist activity at human S1P3 receptor expressed in CHO cells after 4 hrs by fluorescence assay |
ChEMBL | 332 | 5 | 0 | 3 | 5.0 | CC(C)Cc1cc(C(=O)N(C2CCCCC2)C2CCCCC2)no1 | 10.1016/j.bmcl.2013.09.075 | ||
| CHEMBL1999116 | 72788 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human S1P3 receptor expressed in CHO cells after 4 hrs by fluorescence assayAgonist activity at human S1P3 receptor expressed in CHO cells after 4 hrs by fluorescence assay |
ChEMBL | 332 | 5 | 0 | 3 | 5.0 | CC(C)Cc1cc(C(=O)N(C2CCCCC2)C2CCCCC2)no1 | 10.1016/j.bmcl.2013.09.075 | ||
| 67169708 | 182430 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 511 | 5 | 1 | 6 | 5.8 | O=C(O)C1CN(Cc2ccc3c(c2)CCc2c-3noc2-c2nsc(-c3ccccc3)c2C(F)(F)F)C1 | 10.1021/acs.jmedchem.6b01099 | ||
| CHEMBL4784344 | 182430 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting methodAgonist activity at human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 511 | 5 | 1 | 6 | 5.8 | O=C(O)C1CN(Cc2ccc3c(c2)CCc2c-3noc2-c2nsc(-c3ccccc3)c2C(F)(F)F)C1 | 10.1021/acs.jmedchem.6b01099 | ||
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