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Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	71508233	87074	0	None	676	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	355	10	1	3	3.9	CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326201	87074	0	None	676	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	355	10	1	3	3.9	CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	139451781	184858	0	None	2	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4852440	184858	0	None	2	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	46865422	87071	0	None	181	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326199	87071	0	None	181	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	139451764	186267	0	None	2	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4873903	186267	0	None	2	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	1357	2485	139	None	-1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1672	2485	139	None	-1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	224	2485	139	None	-1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	896	2485	139	None	-1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	CHEMBL45	2485	139	None	-1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	DB01065	2485	139	None	-1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	198	313	126	None	3	4	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	82148	313	126	None	3	4	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	99	313	126	None	3	4	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	CHEMBL10878	313	126	None	3	4	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	DB06594	313	126	None	3	4	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	1357	2485	139	None	-1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	1672	2485	139	None	-1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	224	2485	139	None	-1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	896	2485	139	None	-1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	CHEMBL45	2485	139	None	-1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	DB01065	2485	139	None	-1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	139451763	186333	0	None	1	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	305	8	1	5	2.4	CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21	10.1021/acs.jmedchem.0c00627
	CHEMBL4874954	186333	0	None	1	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	305	8	1	5	2.4	CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21	10.1021/acs.jmedchem.0c00627
	137647756	157944	0	None	213	2	Human	10.1	pEC50	=	10.1	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	4	2	3	1.7	CNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4084612	157944	0	None	213	2	Human	10.1	pEC50	=	10.1	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	4	2	3	1.7	CNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	9839629	100116	0	None	1	2	Human	10.0	pEC50	=	10.0	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL287560	100116	0	None	1	2	Human	10.0	pEC50	=	10.0	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	198	313	126	None	3	4	Human	10.0	pEC50	=	10	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	82148	313	126	None	3	4	Human	10.0	pEC50	=	10	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	99	313	126	None	3	4	Human	10.0	pEC50	=	10	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	CHEMBL10878	313	126	None	3	4	Human	10.0	pEC50	=	10	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	DB06594	313	126	None	3	4	Human	10.0	pEC50	=	10	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	198	313	126	None	3	4	Human	10.0	pEC50	=	10	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	82148	313	126	None	3	4	Human	10.0	pEC50	=	10	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	99	313	126	None	3	4	Human	10.0	pEC50	=	10	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	CHEMBL10878	313	126	None	3	4	Human	10.0	pEC50	=	10	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	DB06594	313	126	None	3	4	Human	10.0	pEC50	=	10	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	198	313	126	None	3	4	Human	10.0	pEC50	=	10	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	82148	313	126	None	3	4	Human	10.0	pEC50	=	10	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	99	313	126	None	3	4	Human	10.0	pEC50	=	10	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	CHEMBL10878	313	126	None	3	4	Human	10.0	pEC50	=	10	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	DB06594	313	126	None	3	4	Human	10.0	pEC50	=	10	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	137655238	158885	0	None	891	2	Human	10.0	pEC50	=	10	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4095210	158885	0	None	891	2	Human	10.0	pEC50	=	10	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	71508232	87073	0	None	75	2	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	351	7	1	3	3.6	CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326200	87073	0	None	75	2	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	351	7	1	3	3.6	CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	10926138	207977	0	None	147	2	Human	9.8	pEC50	=	9.8	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	349	8	1	3	4.3	C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL97186	207977	0	None	147	2	Human	9.8	pEC50	=	9.8	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	349	8	1	3	4.3	C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	1357	2485	139	None	-1	5	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	1672	2485	139	None	-1	5	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	224	2485	139	None	-1	5	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	896	2485	139	None	-1	5	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	CHEMBL45	2485	139	None	-1	5	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	DB01065	2485	139	None	-1	5	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	198	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	82148	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	99	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	CHEMBL10878	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	DB06594	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	198	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	198	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	82148	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	82148	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	99	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	99	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	CHEMBL10878	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	CHEMBL10878	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	DB06594	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	DB06594	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	139451769	186142	0	None	5	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC	10.1021/acs.jmedchem.0c00627
	CHEMBL4872217	186142	0	None	5	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC	10.1021/acs.jmedchem.0c00627
	145982070	166475	0	None	-1	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	283	3	1	2	3.2	COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4278248	166475	0	None	-1	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	283	3	1	2	3.2	COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	145986532	167281	0	None	4	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	2	3.0	COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4293386	167281	0	None	4	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	2	3.0	COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	71508235	87075	0	None	14	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	327	8	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326203	87075	0	None	14	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	327	8	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	137636213	156086	0	None	47	2	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4062947	156086	0	None	47	2	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	137639112	156852	0	None	8128	2	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	2	3	1.5	COc1ccc2cccc(CCNC(N)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4071572	156852	0	None	8128	2	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	2	3	1.5	COc1ccc2cccc(CCNC(N)=O)c2n1	10.1016/j.ejmech.2016.12.013
	137660333	159520	0	None	3	2	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	244	4	1	3	1.9	COc1ccc2cccc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4102177	159520	0	None	3	2	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	244	4	1	3	1.9	COc1ccc2cccc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.12.013
	198	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	82148	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	99	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	CHEMBL10878	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	DB06594	313	126	None	3	4	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	71508234	705	0	None	173	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	7924	705	0	None	173	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	CHEMBL2326202	705	0	None	173	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	139451795	185329	0	None	-2	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859677	185329	0	None	-2	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451757	184831	0	None	-3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4852096	184831	0	None	-3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	145990662	166929	0	None	16	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	4	2	2	3.4	CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4286896	166929	0	None	16	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	4	2	2	3.4	CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	139451766	184447	0	None	4	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4846505	184447	0	None	4	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451761	184597	0	None	-4	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4848885	184597	0	None	-4	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	122220128	159675	0	None	27	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	6	2	3	2.3	COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1	10.1039/C4MD00149D
	CHEMBL4104020	159675	0	None	27	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	6	2	3	2.3	COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1	10.1039/C4MD00149D
	10385056	112236	0	None	354	2	Human	9.4	pEC50	=	9.4	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL329086	112236	0	None	354	2	Human	9.4	pEC50	=	9.4	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	145988741	167236	0	None	12	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	299	5	1	3	2.6	COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4292336	167236	0	None	12	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	299	5	1	3	2.6	COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137645530	157723	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	260	4	1	4	2.1	COC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4082097	157723	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	260	4	1	4	2.1	COC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	11824364	112552	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	353	7	1	4	3.7	COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL329960	112552	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	353	7	1	4	3.7	COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	164946945	190229	1	None	3	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5174929	190229	1	None	3	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	1357	2485	139	None	-1	5	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	1672	2485	139	None	-1	5	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	224	2485	139	None	-1	5	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	896	2485	139	None	-1	5	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	CHEMBL45	2485	139	None	-1	5	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	DB01065	2485	139	None	-1	5	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	1357	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	1672	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	224	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	896	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	CHEMBL45	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	DB01065	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	1357	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	1672	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	224	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	896	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	CHEMBL45	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	DB01065	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	1357	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	1672	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	224	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	896	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	CHEMBL45	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	DB01065	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	1357	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	1672	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	224	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	896	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	CHEMBL45	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	DB01065	2485	139	None	-1	5	Human	9.3	pEC50	=	9.3	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	44579115	181835	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	348	6	2	3	4.2	CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	CHEMBL477835	181835	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	348	6	2	3	4.2	CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	57781216	125847	0	None	-8	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648356	125847	0	None	-8	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	139451767	185004	0	None	-5	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854625	185004	0	None	-5	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	24954989	1532	1	None	-25	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	7774	1532	1	None	-25	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	CHEMBL1802025	1532	1	None	-25	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	139451780	185944	0	None	1	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	303	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1	10.1021/acs.jmedchem.0c00627
	CHEMBL4869463	185944	0	None	1	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	303	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1	10.1021/acs.jmedchem.0c00627
	145982333	166557	0	None	2	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4279639	166557	0	None	2	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	12985495	181386	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	377	8	2	3	4.5	CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
	CHEMBL476341	181386	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	377	8	2	3	4.5	CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
	23642307	158895	1	None	39	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4095334	158895	1	None	39	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	53231366	62401	0	None	309	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	363	5	1	3	5.0	CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779804	62401	0	None	309	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	363	5	1	3	5.0	CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	168296374	192518	0	None	-9	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	CHEMBL5209359	192518	0	None	-9	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	53231465	62400	0	None	35	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	237	3	1	2	2.7	CC(=O)NCCc1csc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779803	62400	0	None	35	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	237	3	1	2	2.7	CC(=O)NCCc1csc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	145988269	167190	0	None	12	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	326	5	2	2	3.8	CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4291381	167190	0	None	12	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	326	5	2	2	3.8	CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	52918079	60755	0	None	2	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	261	6	1	4	2.0	CCCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	CHEMBL1760947	60755	0	None	2	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	261	6	1	4	2.0	CCCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	12985494	190629	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	363	7	2	3	4.1	CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
	CHEMBL518113	190629	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	363	7	2	3	4.1	CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
	127026423	137819	0	None	6	2	Human	9.2	pEC50	=	9.2	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759802	137819	0	None	6	2	Human	9.2	pEC50	=	9.2	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	137650611	157512	0	None	91	2	Human	9.2	pEC50	=	9.2	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	244	4	1	3	1.9	CNC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4079784	157512	0	None	91	2	Human	9.2	pEC50	=	9.2	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	244	4	1	3	1.9	CNC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	1353	3435	5	None	51	2	Human	9.1	pEC50	=	9.1	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	9998187	3435	5	None	51	2	Human	9.1	pEC50	=	9.1	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	CHEMBL33549	3435	5	None	51	2	Human	9.1	pEC50	=	9.1	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	10400294	18549	0	None	-	1	Rat	9.1	pEC50	=	9.1	Functional	Agonist activity for its ability to inhibit forskolin-stimulated cAMP accumulation against MT receptorAgonist activity for its ability to inhibit forskolin-stimulated cAMP accumulation against MT receptor	ChEMBL	258	5	1	3	2.6	Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL127570	18549	0	None	-	1	Rat	9.1	pEC50	=	9.1	Functional	Agonist activity for its ability to inhibit forskolin-stimulated cAMP accumulation against MT receptorAgonist activity for its ability to inhibit forskolin-stimulated cAMP accumulation against MT receptor	ChEMBL	258	5	1	3	2.6	Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	139451799	185839	0	None	-3	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	279	5	1	5	1.9	COc1ccc2nc(SC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4867553	185839	0	None	-3	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	279	5	1	5	1.9	COc1ccc2nc(SC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	7922	1956	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	10.1016/j.bmc.2008.08.052
	9798456	1956	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	10.1016/j.bmc.2008.08.052
	CHEMBL476131	1956	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	10.1016/j.bmc.2008.08.052
	23658144	158179	1	None	100	2	Human	9.1	pEC50	=	9.1	Functional	Partial agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4087633	158179	1	None	100	2	Human	9.1	pEC50	=	9.1	Functional	Partial agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	137642160	158392	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	308	5	1	5	1.3	COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4089965	158392	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	308	5	1	5	1.3	COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1	10.1016/j.ejmech.2016.12.013
	1357	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	1672	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	224	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	896	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	CHEMBL45	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	DB01065	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	1357	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	1672	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	224	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	896	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	CHEMBL45	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	DB01065	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	1357	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	1672	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	224	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	896	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	CHEMBL45	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	DB01065	2485	139	None	-1	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	139451790	185296	18	None	-6	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859295	185296	18	None	-6	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	145981162	166497	0	None	2	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	270	3	2	2	2.5	COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4278575	166497	0	None	2	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	270	3	2	2	2.5	COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3	10.1016/j.ejmech.2017.10.025
	127026427	137684	0	None	1	2	Human	9.0	pEC50	=	9.0	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758679	137684	0	None	1	2	Human	9.0	pEC50	=	9.0	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	127026062	137689	0	None	7	2	Human	9.0	pEC50	=	9.0	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758717	137689	0	None	7	2	Human	9.0	pEC50	=	9.0	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	145982167	166611	0	None	3	2	Human	9.0	pEC50	=	9	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	305	4	1	3	2.4	COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4280601	166611	0	None	3	2	Human	9.0	pEC50	=	9	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	305	4	1	3	2.4	COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	12985491	186980	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	411	6	1	2	5.1	COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL490595	186980	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	411	6	1	2	5.1	COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	137637884	156246	0	None	19	2	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	280	3	1	2	3.3	CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4064813	156246	0	None	19	2	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	280	3	1	2	3.3	CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	21581654	60752	1	None	10	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760944	60752	1	None	10	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	127025784	137733	0	None	8	2	Human	9.0	pEC50	=	9.0	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759084	137733	0	None	8	2	Human	9.0	pEC50	=	9.0	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1	10.1016/j.ejmech.2015.12.047
	137650826	157505	0	None	28	2	Human	9.0	pEC50	=	9.0	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4079699	157505	0	None	28	2	Human	9.0	pEC50	=	9.0	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	23658146	157118	1	None	15	2	Human	8.9	pEC50	=	8.9	Functional	Partial agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4074895	157118	1	None	15	2	Human	8.9	pEC50	=	8.9	Functional	Partial agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	11784134	106949	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	391	6	1	3	4.7	COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL314947	106949	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	391	6	1	3	4.7	COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	168274836	190147	0	None	-17	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5173623	190147	0	None	-17	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	52918080	60764	0	None	12	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	287	4	1	4	2.1	COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3	10.1016/j.bmcl.2011.02.097
	CHEMBL1760957	60764	0	None	12	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	287	4	1	4	2.1	COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3	10.1016/j.bmcl.2011.02.097
	1354	3436	15	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	10.1016/j.bmc.2008.08.052
	22133318	3436	15	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	10.1016/j.bmc.2008.08.052
	CHEMBL490188	3436	15	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	10.1016/j.bmc.2008.08.052
	44579259	187114	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	347	6	1	3	4.0	COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL491604	187114	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	347	6	1	3	4.0	COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	53238181	934	0	None	3	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	7780	934	0	None	3	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	CHEMBL1774519	934	0	None	3	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	52918078	60754	0	None	3	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	247	5	1	4	1.6	CCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	CHEMBL1760946	60754	0	None	3	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	247	5	1	4	1.6	CCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	127029516	137634	0	None	3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3occ(CNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758225	137634	0	None	3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3occ(CNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	44579163	182129	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	362	6	1	3	4.3	COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL478217	182129	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	362	6	1	3	4.3	COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	54582195	60762	0	None	9	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	329	5	1	5	1.9	COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760955	60762	0	None	9	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	329	5	1	5	1.9	COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	127025787	137732	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	298	4	2	3	3.4	CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759080	137732	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	298	4	2	3	3.4	CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	137653199	158623	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	218	2	1	2	1.4	CC(=O)NCC1Cc2ccccc2N(C)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4092308	158623	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	218	2	1	2	1.4	CC(=O)NCC1Cc2ccccc2N(C)C1	10.1021/acs.jmedchem.8b00359
	10925526	112334	0	None	47	2	Human	8.0	pEC50	=	8	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	329	6	1	3	4.2	COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL329299	112334	0	None	47	2	Human	8.0	pEC50	=	8	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	329	6	1	3	4.2	COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	145991111	166912	0	None	10	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	319	5	1	3	2.8	CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4286494	166912	0	None	10	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	319	5	1	3	2.8	CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	122178510	121330	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	275	4	2	4	3.0	COc1ccc2[nH]cc(CCc3n[nH]c(=S)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580921	121330	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	275	4	2	4	3.0	COc1ccc2[nH]cc(CCc3n[nH]c(=S)o3)c2c1	10.1021/acs.jmedchem.5b00245
	54581170	60763	0	None	2	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	359	4	1	4	1.8	COc1ccc2c(I)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760956	60763	0	None	2	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	359	4	1	4	1.8	COc1ccc2c(I)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	86273228	121320	0	None	18	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	258	6	2	2	2.4	C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580910	121320	0	None	18	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	258	6	2	2	2.4	C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	122178513	121333	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	288	5	2	5	3.1	CCNc1nnc(Cc2c[nH]c3ccc(OC)cc23)s1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580926	121333	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	288	5	2	5	3.1	CCNc1nnc(Cc2c[nH]c3ccc(OC)cc23)s1	10.1021/acs.jmedchem.5b00245
	145	140	49	None	-63	11	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1832	140	49	None	-63	11	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	CHEMBL7257	140	49	None	-63	11	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	DB14010	140	49	None	-63	11	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	49862736	15137	0	None	-117	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release	ChEMBL	569	3	0	4	6.9	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	CHEMBL1209787	15137	0	None	-117	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release	ChEMBL	569	3	0	4	6.9	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	162663385	181998	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4780509	181998	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
	86273229	121319	1	None	3	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	244	5	2	2	2.0	C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580909	121319	1	None	3	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	244	5	2	2	2.0	C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	9850873	8867	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	564	15	2	4	6.4	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1	10.1016/j.bmc.2010.04.008
	CHEMBL1097314	8867	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	564	15	2	4	6.4	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1	10.1016/j.bmc.2010.04.008
	44359437	29900	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1039/C4MD00149D
	CHEMBL138807	29900	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1039/C4MD00149D
	81689735	121325	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assayAgonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assay	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580916	121325	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assayAgonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assay	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	46845151	8666	0	None	-7	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	499	12	2	4	6.1	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095505	8666	0	None	-7	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	499	12	2	4	6.1	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12	10.1016/j.bmc.2010.04.008
	46919520	15138	0	None	-1479	6	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release	ChEMBL	597	4	0	5	6.3	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	CHEMBL1209788	15138	0	None	-1479	6	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release	ChEMBL	597	4	0	5	6.3	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	11078652	207918	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	351	7	1	3	4.3	CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL96778	207918	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells	ChEMBL	351	7	1	3	4.3	CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	168274836	190147	0	None	-17	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5173623	190147	0	None	-17	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	145986700	167219	0	None	5	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	328	4	2	2	3.5	CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4292109	167219	0	None	5	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	328	4	2	2	3.5	CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	139451776	185011	0	None	-3	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854836	185011	0	None	-3	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	52918077	60753	2	None	1	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760945	60753	2	None	1	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	52953165	62408	0	None	87	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	389	7	1	3	5.6	C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779810	62408	0	None	87	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	389	7	1	3	5.6	C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	9818487	173533	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	319	5	1	2	4.2	COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL453138	173533	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	319	5	1	2	4.2	COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	10266979	99019	0	None	99	2	Human	8.6	pEC50	=	8.6	Functional	Effective concentration against human MT2 (Melatonin) receptor stably expressed in NIH3T3 cells in adenylyl cyclase assayEffective concentration against human MT2 (Melatonin) receptor stably expressed in NIH3T3 cells in adenylyl cyclase assay	ChEMBL	303	3	1	3	2.0	CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
	CHEMBL280142	99019	0	None	99	2	Human	8.6	pEC50	=	8.6	Functional	Effective concentration against human MT2 (Melatonin) receptor stably expressed in NIH3T3 cells in adenylyl cyclase assayEffective concentration against human MT2 (Melatonin) receptor stably expressed in NIH3T3 cells in adenylyl cyclase assay	ChEMBL	303	3	1	3	2.0	CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
	139451784	185395	0	None	1	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	317	7	1	5	2.4	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1	10.1021/acs.jmedchem.0c00627
	CHEMBL4860729	185395	0	None	1	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method	ChEMBL	317	7	1	5	2.4	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1	10.1021/acs.jmedchem.0c00627
	23642306	159073	1	None	17	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4097233	159073	1	None	17	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	145993566	167371	0	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	5	2	2	3.6	CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4294790	167371	0	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	5	2	2	3.6	CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	18360658	8890	0	None	-10	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	518	13	2	5	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097497	8890	0	None	-10	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	518	13	2	5	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	44394435	66927	0	None	-34	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity towards human Melatonin receptor type 1B was determined by its ability to inhibit forskolin stimulated cAMP accumulationAgonist activity towards human Melatonin receptor type 1B was determined by its ability to inhibit forskolin stimulated cAMP accumulation	ChEMBL	361	8	1	2	5.2	CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL186586	66927	0	None	-34	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity towards human Melatonin receptor type 1B was determined by its ability to inhibit forskolin stimulated cAMP accumulationAgonist activity towards human Melatonin receptor type 1B was determined by its ability to inhibit forskolin stimulated cAMP accumulation	ChEMBL	361	8	1	2	5.2	CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	49862664	15123	0	None	-60	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release	ChEMBL	513	3	1	4	5.4	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CNC[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	CHEMBL1209706	15123	0	None	-60	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release	ChEMBL	513	3	1	4	5.4	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CNC[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	162649850	180138	0	None	2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4748822	180138	0	None	2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	162644724	179394	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	321	5	1	4	3.0	COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4739898	179394	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	321	5	1	4	3.0	COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	162656758	180922	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4757920	180922	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	162668689	182758	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	285	5	1	4	2.2	COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4790145	182758	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	285	5	1	4	2.2	COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	1357	2485	139	None	-1	5	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	1672	2485	139	None	-1	5	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	224	2485	139	None	-1	5	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	896	2485	139	None	-1	5	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	CHEMBL45	2485	139	None	-1	5	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	DB01065	2485	139	None	-1	5	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	23658143	156377	1	None	41	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4066279	156377	1	None	41	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	10163052	8521	0	None	-10	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	483	12	2	4	5.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1094212	8521	0	None	-10	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	483	12	2	4	5.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12	10.1016/j.bmc.2010.04.008
	122178509	121328	0	None	9	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580919	121328	0	None	9	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	86273222	121323	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580913	121323	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1	10.1021/acs.jmedchem.5b00245
	49862738	15140	0	None	-36	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release	ChEMBL	555	4	0	4	6.5	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	CHEMBL1209790	15140	0	None	-36	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release	ChEMBL	555	4	0	4	6.5	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	145982333	166557	0	None	2	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4279639	166557	0	None	2	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145979689	166623	0	None	1	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	314	3	2	2	3.1	CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4280791	166623	0	None	1	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	314	3	2	2	3.1	CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145987794	167120	0	None	6	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	298	4	2	2	3.2	CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4290302	167120	0	None	6	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	298	4	2	2	3.2	CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	86273226	121318	0	None	12	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	256	5	2	2	1.9	C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580908	121318	0	None	12	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	256	5	2	2	1.9	C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	137645887	157940	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4084568	157940	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	127026426	137800	0	None	1	2	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759606	137800	0	None	1	2	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	127025783	137738	0	None	8	2	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759160	137738	0	None	8	2	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1	10.1016/j.ejmech.2015.12.047
	162647716	179887	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4745789	179887	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	168296374	192518	0	None	-9	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	CHEMBL5209359	192518	0	None	-9	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	49862665	15124	0	None	-128	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release	ChEMBL	585	5	1	5	5.9	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)CO)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	CHEMBL1209707	15124	0	None	-128	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release	ChEMBL	585	5	1	5	5.9	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)CO)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	19703063	28915	1	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.bmcl.2011.02.097
	CHEMBL137969	28915	1	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.bmcl.2011.02.097
	145992795	166791	0	None	25	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	342	5	2	2	3.9	CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4284223	166791	0	None	25	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	342	5	2	2	3.9	CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	9937825	8868	0	None	-2	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	564	17	2	4	6.7	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097315	8868	0	None	-2	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	564	17	2	4	6.7	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12	10.1016/j.bmc.2010.04.008
	1355	3438	5	None	-5	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	9806449	3438	5	None	-5	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	CHEMBL14453	3438	5	None	-5	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	162658247	181018	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2cnnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4759137	181018	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2cnnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	122178508	121326	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	243	4	1	4	2.3	COc1ccc2[nH]cc(CCc3nnco3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580917	121326	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	243	4	1	4	2.3	COc1ccc2[nH]cc(CCc3nnco3)c2c1	10.1021/acs.jmedchem.5b00245
	49862739	15141	0	None	-23	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release	ChEMBL	583	6	0	4	7.3	CCC(CC)N1C[C@@H](C(=O)N2CCC3(CC2)O[C@H](C(C)(C)C#N)c2cc(C)c(Cl)cc23)[C@H](c2ccc(F)cc2F)C1	10.1016/j.bmcl.2010.06.068
	CHEMBL1209791	15141	0	None	-23	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release	ChEMBL	583	6	0	4	7.3	CCC(CC)N1C[C@@H](C(=O)N2CCC3(CC2)O[C@H](C(C)(C)C#N)c2cc(C)c(Cl)cc23)[C@H](c2ccc(F)cc2F)C1	10.1016/j.bmcl.2010.06.068
	9064	105219	94	None	-2	4	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human MT2R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate ReaderAgonist activity at human MT2R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate Reader	ChEMBL	290	1	5	6	1.5	Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2	10.1016/j.ejmech.2020.112960
	CHEMBL311498	105219	94	None	-2	4	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human MT2R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate ReaderAgonist activity at human MT2R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate Reader	ChEMBL	290	1	5	6	1.5	Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2	10.1016/j.ejmech.2020.112960
	145991966	166836	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	285	3	1	3	3.2	COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4285145	166836	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	285	3	1	3	3.2	COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145986330	167057	0	None	3	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	286	3	2	2	2.7	COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4289115	167057	0	None	3	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	286	3	2	2	2.7	COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3	10.1016/j.ejmech.2017.10.025
	122178509	121328	0	None	9	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assayAgonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assay	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580919	121328	0	None	9	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assayAgonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assay	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	127025781	137824	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759859	137824	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	145983175	166431	0	None	1	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	314	4	2	2	3.4	CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4277390	166431	0	None	1	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	314	4	2	2	3.4	CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	86273470	121322	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	256	4	1	3	3.3	COc1ccc2[nH]cc(CCc3ncc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580912	121322	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	256	4	1	3	3.3	COc1ccc2[nH]cc(CCc3ncc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	162649247	180075	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	351	6	1	5	3.0	COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1	10.1016/j.ejmech.2020.112078
	CHEMBL4747996	180075	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	351	6	1	5	3.0	COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1	10.1016/j.ejmech.2020.112078
	145979282	166675	0	None	1	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4281915	166675	0	None	1	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	127025786	137849	0	None	12	2	Human	8.2	pEC50	=	8.2	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12	10.1016/j.ejmech.2015.12.047
	CHEMBL3760044	137849	0	None	12	2	Human	8.2	pEC50	=	8.2	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12	10.1016/j.ejmech.2015.12.047
	49862740	15142	0	None	-10	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release	ChEMBL	585	6	0	5	6.1	COCC(C)N1C[C@@H](C(=O)N2CCC3(CC2)O[C@H](C(C)(C)C#N)c2cc(C)c(Cl)cc23)[C@H](c2ccc(F)cc2F)C1	10.1016/j.bmcl.2010.06.068
	CHEMBL1209792	15142	0	None	-10	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release	ChEMBL	585	6	0	5	6.1	COCC(C)N1C[C@@H](C(=O)N2CCC3(CC2)O[C@H](C(C)(C)C#N)c2cc(C)c(Cl)cc23)[C@H](c2ccc(F)cc2F)C1	10.1016/j.bmcl.2010.06.068
	137636079	156227	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	232	3	1	2	1.8	CCN1CC(CNC(C)=O)Cc2ccccc21	10.1021/acs.jmedchem.8b00359
	CHEMBL4064626	156227	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	232	3	1	2	1.8	CCN1CC(CNC(C)=O)Cc2ccccc21	10.1021/acs.jmedchem.8b00359
	11351216	62404	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	441	6	1	3	5.4	O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779807	62404	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	441	6	1	3	5.4	O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	23658145	157463	1	None	52	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4079214	157463	1	None	52	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	4018512	43220	42	None	2	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	308	5	2	2	3.5	COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1039/d2md00156j
	CHEMBL15060	43220	42	None	2	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	308	5	2	2	3.5	COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1039/d2md00156j
	122178507	121324	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580915	121324	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	49862737	15139	0	None	-10	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release	ChEMBL	611	5	0	5	6.5	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(CC4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	CHEMBL1209789	15139	0	None	-10	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release	ChEMBL	611	5	0	5	6.5	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(CC4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	127025782	137731	0	None	-1	2	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	297	4	1	3	3.9	COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759054	137731	0	None	-1	2	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	297	4	1	3	3.9	COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1	10.1016/j.ejmech.2015.12.047
	127026425	137820	0	None	-8	2	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759816	137820	0	None	-8	2	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	137656715	159547	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	308	5	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4102517	159547	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	308	5	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	86273227	121317	0	None	3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	242	4	2	2	1.5	C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580907	121317	0	None	3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	242	4	2	2	1.5	C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	86079062	180732	0	None	3	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2ncnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4755860	180732	0	None	3	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2ncnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	46888522	8645	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	513	12	1	5	6.2	COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1	10.1016/j.bmc.2010.04.008
	CHEMBL1095197	8645	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	513	12	1	5	6.2	COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1	10.1016/j.bmc.2010.04.008
	81689735	121325	0	None	-1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580916	121325	0	None	-1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	198	313	126	None	3	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	82148	313	126	None	3	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	99	313	126	None	3	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	CHEMBL10878	313	126	None	3	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	DB06594	313	126	None	3	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	162661094	181443	3	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4764211	181443	3	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	164946945	190229	1	None	3	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5174929	190229	1	None	3	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	44396074	67153	2	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulationAntagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulation	ChEMBL	339	5	0	3	3.8	COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(C)=O)CC2	10.1021/jm401343c
	CHEMBL187593	67153	2	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulationAntagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulation	ChEMBL	339	5	0	3	3.8	COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(C)=O)CC2	10.1021/jm401343c
	9909783	67136	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulationAntagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulation	ChEMBL	415	6	0	3	5.4	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2	10.1021/jm401343c
	CHEMBL187525	67136	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulationAntagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulation	ChEMBL	415	6	0	3	5.4	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2	10.1021/jm401343c
	16094585	82890	0	None	-	0	Human	9.4	pKd	=	9.4	Functional	Activity at human MT2 receptor expressed in NIH3T3 cells assessed as inhibition of MLT-stimulated [35S]GTPgammaS bindingActivity at human MT2 receptor expressed in NIH3T3 cells assessed as inhibition of MLT-stimulated [35S]GTPgammaS binding	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
	CHEMBL218065	82890	0	None	-	0	Human	9.4	pKd	=	9.4	Functional	Activity at human MT2 receptor expressed in NIH3T3 cells assessed as inhibition of MLT-stimulated [35S]GTPgammaS bindingActivity at human MT2 receptor expressed in NIH3T3 cells assessed as inhibition of MLT-stimulated [35S]GTPgammaS binding	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
	90655902	110867	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Agonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	330	5	2	4	2.5	CCOC(=O)c1[nH]c2ccc(OC)c3c2c1[C@@H](CNC(C)=O)CC3	10.1021/jm401343c
	CHEMBL3260982	110867	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Agonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	330	5	2	4	2.5	CCOC(=O)c1[nH]c2ccc(OC)c3c2c1[C@@H](CNC(C)=O)CC3	10.1021/jm401343c
	52918077	60753	2	None	1	2	Human	9.2	pKi	=	9.2	Functional	Agonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assayAgonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assay	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1021/jm401343c
	CHEMBL1760945	60753	2	None	1	2	Human	9.2	pKi	=	9.2	Functional	Agonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assayAgonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assay	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1021/jm401343c
	11185529	3914	5	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assayAntagonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assay	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm401343c
	7772	3914	5	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assayAntagonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assay	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm401343c
	CHEMBL189449	3914	5	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assayAntagonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assay	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm401343c
	24763223	216	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Agonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1021/jm401343c
	8289	216	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Agonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1021/jm401343c
	CHEMBL3260987	216	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Agonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1021/jm401343c
	1357	2485	139	None	-1	5	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2485	139	None	-1	5	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2485	139	None	-1	5	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2485	139	None	-1	5	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2485	139	None	-1	5	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2485	139	None	-1	5	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	10666	3920	0	None	-21	2	Human	6.0	pEC50	=	6.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	4	2	3	4.5	Clc1ccc(c(c1)Br)CNc1cccc(c1)c1nnc[nH]1	32040955
	138993662	3920	0	None	-21	2	Human	6.0	pEC50	=	6.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	4	2	3	4.5	Clc1ccc(c(c1)Br)CNc1cccc(c1)c1nnc[nH]1	32040955
	10665	3918	0	None	-50	2	Human	6.2	pEC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	3	4.2	CC(c1ccc(cc1)CNc1cccc(c1)c1[nH]cnn1)C	32040955
	137977202	3918	0	None	-50	2	Human	6.2	pEC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	3	4.2	CC(c1ccc(cc1)CNc1cccc(c1)c1[nH]cnn1)C	32040955
	103828029	3919	0	None	20	2	Human	8.2	pEC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	292	4	1	3	3.5	COc1ccc(c(c1)CNc1cccnc1)Br	32040955
	10667	3919	0	None	20	2	Human	8.2	pEC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	292	4	1	3	3.5	COc1ccc(c(c1)CNc1cccnc1)Br	32040955

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		10440	2680	20	None	-3	3	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
		139030523	2680	20	None	-3	3	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
		CHEMBL4449712	2680	20	None	-3	3	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
		23634404	125850	0	None	-	0	Human	10.3	pIC50	=	10.3	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	nan
		CHEMBL3648359	125850	0	None	-	0	Human	10.3	pIC50	=	10.3	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	nan
		57781211	125852	0	None	-	0	Human	10.0	pIC50	=	10.0	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	376	8	1	3	4.9	CC(=O)NCCC1CCc2ccc3nc(CCCCc4ccccc4)oc3c21	nan
		CHEMBL3648361	125852	0	None	-	0	Human	10.0	pIC50	=	10.0	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	376	8	1	3	4.9	CC(=O)NCCC1CCc2ccc3nc(CCCCc4ccccc4)oc3c21	nan
		23725569	125854	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)sc3c21	nan
		CHEMBL3648363	125854	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)sc3c21	nan
		57781216	125847	0	None	-2	2	Human	9.9	pIC50	=	9.9	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	nan
		CHEMBL3648356	125847	0	None	-2	2	Human	9.9	pIC50	=	9.9	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	nan
		57781258	125860	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	312	3	1	3	3.2	Cc1nc2ccc3c(c2o1)C(CCNC(=O)C(F)(F)F)CC3	nan
		CHEMBL3648369	125860	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	312	3	1	3	3.2	Cc1nc2ccc3c(c2o1)C(CCNC(=O)C(F)(F)F)CC3	nan
		57781244	160833	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	270	3	1	3	3.0	CCC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21	nan
		CHEMBL4114700	160833	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	270	3	1	3	3.0	CCC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21	nan
		57781280	160964	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	2	1	3	3.1	CC(=O)NC/C=C1\CCc2ccc3nc(C)sc3c21	nan
		CHEMBL4115681	160964	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	2	1	3	3.1	CC(=O)NC/C=C1\CCc2ccc3nc(C)sc3c21	nan
		23725512	125844	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	256	3	1	3	2.6	CC(=O)NCCC1=CCc2ccc3nc(C)oc3c21	nan
		CHEMBL3648350	125844	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	256	3	1	3	2.6	CC(=O)NCCC1=CCc2ccc3nc(C)oc3c21	nan
		23725514	125849	0	None	-1	2	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21	nan
		CHEMBL3648358	125849	0	None	-1	2	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21	nan
		23725567	125853	0	None	-2	2	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCCC1CCc2ccc3nc(C)sc3c21	nan
		CHEMBL3648362	125853	0	None	-2	2	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCCC1CCc2ccc3nc(C)sc3c21	nan
		23725612	125858	0	None	2	2	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	4	1	4	2.4	COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	nan
		CHEMBL3648367	125858	0	None	2	2	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	4	1	4	2.4	COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	nan
		1357	2485	139	None	1	9	Human	9.5	pIC50	=	9.5	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
		1672	2485	139	None	1	9	Human	9.5	pIC50	=	9.5	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
		224	2485	139	None	1	9	Human	9.5	pIC50	=	9.5	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
		896	2485	139	None	1	9	Human	9.5	pIC50	=	9.5	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
		CHEMBL45	2485	139	None	1	9	Human	9.5	pIC50	=	9.5	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
		DB01065	2485	139	None	1	9	Human	9.5	pIC50	=	9.5	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
		57781227	125845	0	None	6	2	Human	9.5	pIC50	=	9.5	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	244	3	1	3	2.4	CC(=O)NCCC1CCc2ccc3ncoc3c21	nan
		CHEMBL3648354	125845	0	None	6	2	Human	9.5	pIC50	=	9.5	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	244	3	1	3	2.4	CC(=O)NCCC1CCc2ccc3ncoc3c21	nan
		23725565	125846	0	None	-1	2	Human	9.5	pIC50	=	9.5	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCCC1CCc2ccc3nc(C)oc3c21	nan
		CHEMBL3648355	125846	0	None	-1	2	Human	9.5	pIC50	=	9.5	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCCC1CCc2ccc3nc(C)oc3c21	nan
		57781268	160830	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	256	2	1	3	2.6	CC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21	nan
		CHEMBL4114658	160830	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	256	2	1	3	2.6	CC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21	nan
		23725515	125856	0	None	1	2	Human	9.4	pIC50	=	9.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	2.9	CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	nan
		CHEMBL3648365	125856	0	None	1	2	Human	9.4	pIC50	=	9.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	2.9	CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	nan
		57781262	160836	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	374	7	1	3	4.9	CC(=O)NC/C=C1\CCc2ccc3nc(CCCCc4ccccc4)oc3c21	nan
		CHEMBL4114715	160836	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	374	7	1	3	4.9	CC(=O)NC/C=C1\CCc2ccc3nc(CCCCc4ccccc4)oc3c21	nan
		1357	2485	139	None	1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
		1672	2485	139	None	1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
		224	2485	139	None	1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
		896	2485	139	None	1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
		CHEMBL45	2485	139	None	1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
		DB01065	2485	139	None	1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
		1357	2485	139	None	1	9	Human	9.3	pIC50	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
		1672	2485	139	None	1	9	Human	9.3	pIC50	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
		224	2485	139	None	1	9	Human	9.3	pIC50	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
		896	2485	139	None	1	9	Human	9.3	pIC50	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
		CHEMBL45	2485	139	None	1	9	Human	9.3	pIC50	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
		DB01065	2485	139	None	1	9	Human	9.3	pIC50	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
		10059864	109823	5	None	-2	2	Human	9.2	pIC50	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
		CHEMBL323332	109823	5	None	-2	2	Human	9.2	pIC50	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
		57781246	125857	0	None	2	2	Human	9.1	pIC50	=	9.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	284	4	1	3	3.3	CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21	nan
		CHEMBL3648366	125857	0	None	2	2	Human	9.1	pIC50	=	9.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	284	4	1	3	3.3	CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21	nan
		57781261	125859	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	284	4	1	3	3.1	Cc1nc2ccc3c(c2o1)C(CCNC(=O)C1CC1)CC3	nan
		CHEMBL3648368	125859	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	284	4	1	3	3.1	Cc1nc2ccc3c(c2o1)C(CCNC(=O)C1CC1)CC3	nan
		9859969	175023	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	259	4	1	2	3.2	CSc1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
		CHEMBL456727	175023	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	259	4	1	2	3.2	CSc1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
		22375372	67258	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	302	3	0	3	2.5	COc1ccc2c(c1)C(N1CCN(C(=O)C(C)C)CC1)CC2	10.1016/s0960-894x(03)00090-8
		CHEMBL18808	67258	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	302	3	0	3	2.5	COc1ccc2c(c1)C(N1CCN(C(=O)C(C)C)CC1)CC2	10.1016/s0960-894x(03)00090-8
		44272486	69828	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	302	3	0	3	2.5	COc1ccc2c(c1)[C@H](N1CCN(C(=O)C(C)C)CC1)CC2	10.1016/s0960-894x(03)00090-8
		CHEMBL19374	69828	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	302	3	0	3	2.5	COc1ccc2c(c1)[C@H](N1CCN(C(=O)C(C)C)CC1)CC2	10.1016/s0960-894x(03)00090-8
		44272591	71705	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	300	3	0	3	2.2	COc1ccc2c(c1)[C@H](N1CCN(C(=O)C3CC3)CC1)CC2	10.1016/s0960-894x(03)00090-8
		CHEMBL19653	71705	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	300	3	0	3	2.2	COc1ccc2c(c1)[C@H](N1CCN(C(=O)C3CC3)CC1)CC2	10.1016/s0960-894x(03)00090-8
		10266979	99019	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	303	3	1	3	2.0	CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
		CHEMBL280142	99019	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	303	3	1	3	2.0	CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
		11213541	127504	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	469	6	0	3	5.9	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C(F)(F)F)CC2	10.1016/j.bmcl.2004.09.024
		CHEMBL366115	127504	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	469	6	0	3	5.9	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C(F)(F)F)CC2	10.1016/j.bmcl.2004.09.024
		10198772	193083	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	246	4	2	3	1.2	CC(=O)NCCc1coc2ccc(C(N)=O)cc12	10.1016/j.bmc.2008.03.036
		CHEMBL522528	193083	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	246	4	2	3	1.2	CC(=O)NCCc1coc2ccc(C(N)=O)cc12	10.1016/j.bmc.2008.03.036
		44396113	66842	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	469	6	0	3	6.1	COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)c1ccc(C(F)(F)F)cc1)CC2	10.1016/j.bmcl.2004.09.024
		CHEMBL186167	66842	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	469	6	0	3	6.1	COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)c1ccc(C(F)(F)F)cc1)CC2	10.1016/j.bmcl.2004.09.024
		44272252	98722	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	316	5	0	3	3.0	CCCCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
		CHEMBL277828	98722	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	316	5	0	3	3.0	CCCCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
		11784859	123295	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	477	7	0	3	6.7	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)c1ccccc1)CC2	10.1016/j.bmcl.2004.09.024
		CHEMBL361458	123295	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	477	7	0	3	6.7	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)c1ccccc1)CC2	10.1016/j.bmcl.2004.09.024
		44396149	66999	4	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	355	4	0	1	5.4	CC(=O)N1CCc2ccccc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		CHEMBL186915	66999	4	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	355	4	0	1	5.4	CC(=O)N1CCc2ccccc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		44395896	66864	3	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	373	4	0	1	5.5	CC(=O)N1CCc2cc(F)ccc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		CHEMBL186251	66864	3	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	373	4	0	1	5.5	CC(=O)N1CCc2cc(F)ccc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		46919520	15138	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human melatonin receptor type 1BInhibition of human melatonin receptor type 1B	ChEMBL	597	4	0	5	6.3	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
		CHEMBL1209788	15138	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human melatonin receptor type 1BInhibition of human melatonin receptor type 1B	ChEMBL	597	4	0	5	6.3	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
		44396148	66989	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	340	5	1	3	3.3	COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(N)=O)CC2	10.1016/j.bmcl.2004.09.024
		CHEMBL186866	66989	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	340	5	1	3	3.3	COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(N)=O)CC2	10.1016/j.bmcl.2004.09.024
		22375370	68013	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	302	4	0	3	2.6	CCCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
		CHEMBL19123	68013	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	302	4	0	3	2.6	CCCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
		18175057	187395	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	314	4	2	3	2.6	CC(=O)NCCc1coc2ccc(NC(=O)C(F)(F)F)cc12	10.1016/j.bmc.2008.03.036
		CHEMBL493607	187395	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	314	4	2	3	2.6	CC(=O)NCCc1coc2ccc(NC(=O)C(F)(F)F)cc12	10.1016/j.bmc.2008.03.036
		11430378	168219	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	431	6	0	4	5.6	COC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		CHEMBL433573	168219	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	431	6	0	4	5.6	COC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		44396058	67049	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	407	6	0	3	5.3	COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)C1CCCCC1)CC2	10.1016/j.bmcl.2004.09.024
		CHEMBL187148	67049	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	407	6	0	3	5.3	COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)C1CCCCC1)CC2	10.1016/j.bmcl.2004.09.024
		44272451	67651	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	294	4	0	3	2.1	COc1ccc(F)c(CN2CCN(C(=O)C(C)C)CC2)c1	10.1016/s0960-894x(03)00090-8
		CHEMBL19061	67651	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	294	4	0	3	2.1	COc1ccc(F)c(CN2CCN(C(=O)C(C)C)CC2)c1	10.1016/s0960-894x(03)00090-8
		11178762	67006	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	463	5	0	2	6.1	COc1cc2c(cc1Br)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		CHEMBL186941	67006	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	463	5	0	2	6.1	COc1cc2c(cc1Br)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		44396057	127092	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	379	6	0	3	4.6	COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)C1CCC1)CC2	10.1016/j.bmcl.2004.09.024
		CHEMBL365648	127092	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	379	6	0	3	4.6	COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)C1CCC1)CC2	10.1016/j.bmcl.2004.09.024
		44396034	127303	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	455	7	0	3	6.2	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCC1)CC2	10.1016/j.bmcl.2004.09.024
		CHEMBL365899	127303	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	455	7	0	3	6.2	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCC1)CC2	10.1016/j.bmcl.2004.09.024
		17957000	61405	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	286	4	2	3	2.7	COC(=O)Nc1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
		CHEMBL1770214	61405	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	286	4	2	3	2.7	COC(=O)Nc1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
		44272539	67124	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	292	4	0	3	1.9	COc1ccc(F)c(CN2CCN(C(=O)C3CC3)CC2)c1	10.1016/s0960-894x(03)00090-8
		CHEMBL18747	67124	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	292	4	0	3	1.9	COc1ccc(F)c(CN2CCN(C(=O)C3CC3)CC2)c1	10.1016/s0960-894x(03)00090-8
		44396136	168424	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	385	5	0	2	5.4	COc1ccc2c(c1)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		CHEMBL434916	168424	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	385	5	0	2	5.4	COc1ccc2c(c1)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		44395939	123685	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	471	10	0	3	6.9	CCCCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		CHEMBL362162	123685	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	471	10	0	3	6.9	CCCCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		22375366	69493	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	300	3	0	3	2.2	COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CC2	10.1016/s0960-894x(03)00090-8
		CHEMBL19339	69493	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	300	3	0	3	2.2	COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CC2	10.1016/s0960-894x(03)00090-8
		22375392	99182	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	303	3	1	3	2.0	CCNC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
		CHEMBL281345	99182	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	303	3	1	3	2.0	CCNC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
		11247050	66867	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	416	6	1	3	4.9	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(N)=O)CC2	10.1016/j.bmcl.2004.09.024
		CHEMBL186262	66867	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	416	6	1	3	4.9	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(N)=O)CC2	10.1016/j.bmcl.2004.09.024
		44396034	127303	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	455	7	0	3	6.2	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCC1)CC2	10.1016/j.bmcl.2004.09.024
		CHEMBL365899	127303	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	455	7	0	3	6.2	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCC1)CC2	10.1016/j.bmcl.2004.09.024
		22375417	67264	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	288	3	0	3	2.2	CCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
		CHEMBL18810	67264	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	288	3	0	3	2.2	CCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
		44395994	66737	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	483	7	0	3	6.9	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCCCC1)CC2	10.1016/j.bmcl.2004.09.024
		CHEMBL185733	66737	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	483	7	0	3	6.9	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCCCC1)CC2	10.1016/j.bmcl.2004.09.024
		18175008	175495	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	292	4	2	3	1.2	CC(=O)NCCc1cccc2ccc(S(N)(=O)=O)cc12	10.1016/j.ejmech.2011.02.010
		CHEMBL457763	175495	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	292	4	2	3	1.2	CC(=O)NCCc1cccc2ccc(S(N)(=O)=O)cc12	10.1016/j.ejmech.2011.02.010
		9861677	187559	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	315	5	1	4	3.1	COC(=O)c1ccc2occ(CCNC(=O)C3CCCC3)c2c1	10.1016/j.bmc.2008.03.036
		CHEMBL494566	187559	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	315	5	1	4	3.1	COC(=O)c1ccc2occ(CCNC(=O)C3CCCC3)c2c1	10.1016/j.bmc.2008.03.036
		44396073	67152	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	485	11	0	3	7.3	CCCCCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		CHEMBL187592	67152	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	485	11	0	3	7.3	CCCCCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		4284525	188714	42	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	275	4	3	3	2.0	COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
		CHEMBL504585	188714	42	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	275	4	3	3	2.0	COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
		4284525	188714	42	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	275	4	3	3	2.0	COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
		CHEMBL504585	188714	42	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	275	4	3	3	2.0	COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
		22037991	98671	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	274	2	0	3	1.8	COc1ccc2c(c1)C(N1CCN(C(C)=O)CC1)CC2	10.1016/s0960-894x(03)00090-8
		CHEMBL277429	98671	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	274	2	0	3	1.8	COc1ccc2c(c1)C(N1CCN(C(C)=O)CC1)CC2	10.1016/s0960-894x(03)00090-8
		44395915	67046	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	415	6	0	3	5.4	COc1cc2c(c(OC)c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2	10.1016/j.bmcl.2004.09.024
		CHEMBL187136	67046	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	415	6	0	3	5.4	COc1cc2c(c(OC)c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2	10.1016/j.bmcl.2004.09.024
		17957007	192655	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	304	5	2	4	2.9	COC(=O)Nc1ccc2occ(CCNC(=O)C(C)C)c2c1	10.1016/j.bmc.2008.03.036
		CHEMBL521826	192655	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	304	5	2	4	2.9	COC(=O)Nc1ccc2occ(CCNC(=O)C(C)C)c2c1	10.1016/j.bmc.2008.03.036
		9064	105219	94	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cellsAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells	ChEMBL	290	1	5	6	1.5	Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2	10.1016/j.bmc.2021.116270
		CHEMBL311498	105219	94	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cellsAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells	ChEMBL	290	1	5	6	1.5	Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2	10.1016/j.bmc.2021.116270
		11749479	66898	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	385	5	0	2	5.4	COc1ccc2c(c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2	10.1016/j.bmcl.2004.09.024
		CHEMBL186452	66898	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	385	5	0	2	5.4	COc1ccc2c(c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2	10.1016/j.bmcl.2004.09.024
		44576406	187370	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	330	5	2	4	3.5	COC(=O)Nc1ccc2occ(CCNC(=O)C3CCCC3)c2c1	10.1016/j.bmc.2008.03.036
		CHEMBL493414	187370	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	330	5	2	4	3.5	COC(=O)Nc1ccc2occ(CCNC(=O)C3CCCC3)c2c1	10.1016/j.bmc.2008.03.036
		44593610	187372	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	302	6	2	4	2.8	C=CCC(=O)NCCc1coc2ccc(NC(=O)OC)cc12	10.1016/j.bmc.2008.03.036
		CHEMBL493424	187372	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	302	6	2	4	2.8	C=CCC(=O)NCCc1coc2ccc(NC(=O)OC)cc12	10.1016/j.bmc.2008.03.036
		25014882	187695	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	302	5	2	4	2.7	COC(=O)Nc1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1016/j.bmc.2008.03.036
		CHEMBL495232	187695	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	302	5	2	4	2.7	COC(=O)Nc1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1016/j.bmc.2008.03.036
		23725566	125851	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	nan
		CHEMBL3648360	125851	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	nan
		53827707	110866	3	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to MT2 receptor (unknown origin) expressed in HEK293 cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	279	6	1	3	3.0	CCCNC(=O)CCCc1cccc2c1SCCO2	10.1021/jm401343c
		CHEMBL3260981	110866	3	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to MT2 receptor (unknown origin) expressed in HEK293 cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	279	6	1	3	3.0	CCCNC(=O)CCCc1cccc2c1SCCO2	10.1021/jm401343c
		11304981	66928	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	430	6	1	3	5.2	CNC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		CHEMBL186590	66928	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	430	6	1	3	5.2	CNC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		11304958	67266	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	429	7	0	3	5.8	CCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		CHEMBL188120	67266	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	429	7	0	3	5.8	CCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		18175032	175596	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	358	6	2	4	2.3	CNS(=O)(=O)c1ccc2cccc(CCNC(=O)c3ccco3)c2c1	10.1016/j.ejmech.2011.02.010
		CHEMBL457992	175596	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	358	6	2	4	2.3	CNS(=O)(=O)c1ccc2cccc(CCNC(=O)c3ccco3)c2c1	10.1016/j.ejmech.2011.02.010
		22375402	98357	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	314	3	0	3	2.6	COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CCC2	10.1016/s0960-894x(03)00090-8
		CHEMBL275205	98357	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	314	3	0	3	2.6	COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CCC2	10.1016/s0960-894x(03)00090-8
		44396074	67153	2	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	339	5	0	3	3.8	COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(C)=O)CC2	10.1016/j.bmcl.2004.09.024
		CHEMBL187593	67153	2	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	339	5	0	3	3.8	COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(C)=O)CC2	10.1016/j.bmcl.2004.09.024
		11476283	66897	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	443	8	0	3	6.2	CCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		CHEMBL186451	66897	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	443	8	0	3	6.2	CCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
		23725568	125855	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCC[C@H]1CCc2ccc3nc(C)sc3c21	nan
		CHEMBL3648364	125855	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCC[C@H]1CCc2ccc3nc(C)sc3c21	nan
		44396100	122048	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	545	7	0	3	7.7	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)c1ccc(C(F)(F)F)cc1)CC2	10.1016/j.bmcl.2004.09.024
		CHEMBL359576	122048	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	545	7	0	3	7.7	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)c1ccc(C(F)(F)F)cc1)CC2	10.1016/j.bmcl.2004.09.024
		10663827	122927	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	325	6	0	3	3.4	COc1cc2c(cc1OC)C(CCc1ccccc1)N(C=O)CC2	10.1016/j.bmcl.2004.09.024
		CHEMBL360641	122927	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	325	6	0	3	3.4	COc1cc2c(cc1OC)C(CCc1ccccc1)N(C=O)CC2	10.1016/j.bmcl.2004.09.024
		21916760	175699	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	291	4	1	3	1.9	CC(=O)NCCc1cccc2ccc(S(C)(=O)=O)cc12	10.1016/j.ejmech.2011.02.010
		CHEMBL458209	175699	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	291	4	1	3	1.9	CC(=O)NCCc1cccc2ccc(S(C)(=O)=O)cc12	10.1016/j.ejmech.2011.02.010
		23725513	125848	0	None	3	2	Human	8.0	pIC50	=	8.0	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	nan
		CHEMBL3648357	125848	0	None	3	2	Human	8.0	pIC50	=	8.0	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	nan
		9909783	67136	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	415	6	0	3	5.4	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2	10.1016/j.bmcl.2004.09.024
		CHEMBL187525	67136	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	415	6	0	3	5.4	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2	10.1016/j.bmcl.2004.09.024
		11361621	125807	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	401	7	0	3	5.0	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C=O)CC2	10.1016/j.bmcl.2004.09.024
		CHEMBL364816	125807	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B	ChEMBL	401	7	0	3	5.0	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C=O)CC2	10.1016/j.bmcl.2004.09.024
		44272521	70313	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	310	3	0	3	2.9	COc1ccc2cccc(N3CCN(C(=O)C4CC4)CC3)c2c1	10.1016/s0960-894x(03)00090-8
		CHEMBL19442	70313	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	310	3	0	3	2.9	COc1ccc2cccc(N3CCN(C(=O)C4CC4)CC3)c2c1	10.1016/s0960-894x(03)00090-8
		22375407	70638	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	317	3	1	3	2.4	CCNC(=O)N1CCN(C2CCCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
		CHEMBL19503	70638	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.	ChEMBL	317	3	1	3	2.4	CCNC(=O)N1CCN(C2CCCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
		9817006	174984	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	275	4	1	2	2.3	CC(=O)NCCc1cccc2ccc([S+](C)[O-])cc12	10.1016/j.ejmech.2011.02.010
		CHEMBL456646	174984	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor	ChEMBL	275	4	1	2	2.3	CC(=O)NCCc1cccc2ccc([S+](C)[O-])cc12	10.1016/j.ejmech.2011.02.010
		1357	2485	139	None	1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT2 (unknown origin)Binding affinity to melatonin receptor MT2 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
		1672	2485	139	None	1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT2 (unknown origin)Binding affinity to melatonin receptor MT2 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
		224	2485	139	None	1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT2 (unknown origin)Binding affinity to melatonin receptor MT2 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
		896	2485	139	None	1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT2 (unknown origin)Binding affinity to melatonin receptor MT2 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
		CHEMBL45	2485	139	None	1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT2 (unknown origin)Binding affinity to melatonin receptor MT2 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
		DB01065	2485	139	None	1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT2 (unknown origin)Binding affinity to melatonin receptor MT2 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
		10440	2680	20	None	-3	3	Human	6.0	pKd	=	6.0	Binding	Agonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
		139030523	2680	20	None	-3	3	Human	6.0	pKd	=	6.0	Binding	Agonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
		CHEMBL4449712	2680	20	None	-3	3	Human	6.0	pKd	=	6.0	Binding	Agonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
		11723593	106878	0	None	1	2	Human	11.0	pKi	=	11	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	321	6	1	3	4.0	C=CC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
		CHEMBL314512	106878	0	None	1	2	Human	11.0	pKi	=	11	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	321	6	1	3	4.0	C=CC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
		53237949	62017	0	None	3	2	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	339	4	1	2	3.7	CC(C)C1=C(CCNC(=O)C(F)(F)F)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
		CHEMBL1774516	62017	0	None	3	2	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	339	4	1	2	3.7	CC(C)C1=C(CCNC(=O)C(F)(F)F)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
		53237947	62015	0	None	1	2	Human	11.0	pKi	=	11.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	299	5	1	2	3.5	CCC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
		CHEMBL1774514	62015	0	None	1	2	Human	11.0	pKi	=	11.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	299	5	1	2	3.5	CCC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
		53238410	62028	0	None	1174	2	Human	11.0	pKi	=	11.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	361	5	1	2	4.7	CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
		CHEMBL1774529	62028	0	None	1174	2	Human	11.0	pKi	=	11.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	361	5	1	2	4.7	CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
		53238181	934	0	None	741	2	Human	10.9	pKi	=	10.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
		7780	934	0	None	741	2	Human	10.9	pKi	=	10.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
		CHEMBL1774519	934	0	None	741	2	Human	10.9	pKi	=	10.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
		53238183	62021	2	None	-	1	Human	10.9	pKi	=	10.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	321	3	1	2	2.8	CC(=O)NCCC1=C(Br)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
		CHEMBL1774521	62021	2	None	-	1	Human	10.9	pKi	=	10.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	321	3	1	2	2.8	CC(=O)NCCC1=C(Br)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
		1358	124	41	None	870	2	Human	10.8	pKi	=	10.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm048956y
		3976006	124	41	None	870	2	Human	10.8	pKi	=	10.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm048956y
		CHEMBL285718	124	41	None	870	2	Human	10.8	pKi	=	10.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm048956y
		53237946	62014	0	None	1	2	Human	10.7	pKi	=	10.7	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	285	4	1	2	3.1	CC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
		CHEMBL1774513	62014	0	None	1	2	Human	10.7	pKi	=	10.7	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	285	4	1	2	3.1	CC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
		9839629	100116	0	None	-1	2	Human	10.7	pKi	=	10.7	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		CHEMBL287560	100116	0	None	-1	2	Human	10.7	pKi	=	10.7	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		10925712	112580	0	None	-1	2	Human	10.7	pKi	=	10.7	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	7	1	3	4.3	C=CCC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
		CHEMBL330137	112580	0	None	-1	2	Human	10.7	pKi	=	10.7	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	7	1	3	4.3	C=CCC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
		9839629	100116	0	None	-1	2	Human	10.7	pKi	=	10.7	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 mins	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.5b00982
		CHEMBL287560	100116	0	None	-1	2	Human	10.7	pKi	=	10.7	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 mins	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.5b00982
		53238186	62024	0	None	54	2	Human	10.7	pKi	=	10.7	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1ccccc1C1=C(CCNC(C)=O)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
		CHEMBL1774525	62024	0	None	54	2	Human	10.7	pKi	=	10.7	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1ccccc1C1=C(CCNC(C)=O)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
		22004791	62013	0	None	2	2	Human	10.7	pKi	=	10.7	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	243	3	1	2	2.1	CC(=O)NCCC1=CCc2ccc3c(c21)CCO3	10.1021/jm200221q
		CHEMBL1774512	62013	0	None	2	2	Human	10.7	pKi	=	10.7	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	243	3	1	2	2.1	CC(=O)NCCC1=CCc2ccc3c(c21)CCO3	10.1021/jm200221q
		24750077	149044	0	None	691	2	Human	10.6	pKi	=	10.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	314	7	1	4	3.0	COc1cccc(N(CCNC(C)=O)c2cccc(OC)c2)c1	10.1021/jm700957j
		CHEMBL394273	149044	0	None	691	2	Human	10.6	pKi	=	10.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	314	7	1	4	3.0	COc1cccc(N(CCNC(C)=O)c2cccc(OC)c2)c1	10.1021/jm700957j
		137642160	158392	0	None	165	2	Human	10.5	pKi	=	10.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	308	5	1	5	1.3	COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1	10.1016/j.ejmech.2016.12.013
		CHEMBL4089965	158392	0	None	165	2	Human	10.5	pKi	=	10.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	308	5	1	5	1.3	COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1	10.1016/j.ejmech.2016.12.013
		127042442	137911	0	None	6	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	328	5	1	4	3.3	COc1ccc2oc(-c3ccc(F)cc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		CHEMBL3763503	137911	0	None	6	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	328	5	1	4	3.3	COc1ccc2oc(-c3ccc(F)cc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		71533430	86414	0	None	1	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	241	3	1	2	3.0	COc1ccc2cccc(/C=C/NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
		CHEMBL2314255	86414	0	None	1	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	241	3	1	2	3.0	COc1ccc2cccc(/C=C/NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
		46884551	8185	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	373	10	1	5	3.4	COc1cc(COc2ccc(OC)cc2CCCNC(C)=O)cc(OC)c1	10.1016/j.bmcl.2010.02.084
		CHEMBL1091998	8185	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	373	10	1	5	3.4	COc1cc(COc2ccc(OC)cc2CCCNC(C)=O)cc(OC)c1	10.1016/j.bmcl.2010.02.084
		18466111	19845	0	None	-1	2	Human	10.5	pKi	=	10.5	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
		CHEMBL130214	19845	0	None	-1	2	Human	10.5	pKi	=	10.5	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
		53238185	62023	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	320	4	1	3	3.0	CC(=O)NCCC1=C(c2cccnc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
		CHEMBL1774524	62023	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	320	4	1	3	3.0	CC(=O)NCCC1=C(c2cccnc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
		53237948	62016	0	None	3	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	311	5	1	2	3.5	CC(C)C1=C(CCNC(=O)C2CC2)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
		CHEMBL1774515	62016	0	None	3	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	311	5	1	2	3.5	CC(C)C1=C(CCNC(=O)C2CC2)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
		53238408	62026	0	None	81	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1ccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)cc1	10.1021/jm200221q
		CHEMBL1774527	62026	0	None	81	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1ccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)cc1	10.1021/jm200221q
		1351	2395	21	None	1	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity to MT2 receptor (unknown origin)Binding affinity to MT2 receptor (unknown origin)	ChEMBL	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	10.1039/C4MD00149D
		219018	2395	21	None	1	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity to MT2 receptor (unknown origin)Binding affinity to MT2 receptor (unknown origin)	ChEMBL	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	10.1039/C4MD00149D
		CHEMBL4079759	2395	21	None	1	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity to MT2 receptor (unknown origin)Binding affinity to MT2 receptor (unknown origin)	ChEMBL	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	10.1039/C4MD00149D
		9873402	35839	0	None	-1	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	596	19	2	4	7.9	CC(=O)NCCc1cccc2ccc(OCCCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
		CHEMBL14417	35839	0	None	-1	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	596	19	2	4	7.9	CC(=O)NCCc1cccc2ccc(OCCCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
		10925379	207565	0	None	-1	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	324	5	2	3	3.6	CNC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
		CHEMBL94838	207565	0	None	-1	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	324	5	2	3	3.6	CNC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
		44272335	68676	0	None	23	2	Human	10.4	pKi	=	10.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	302	7	2	3	3.6	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCC)N2	10.1016/j.bmcl.2003.12.052
		CHEMBL19211	68676	0	None	23	2	Human	10.4	pKi	=	10.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	302	7	2	3	3.6	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCC)N2	10.1016/j.bmcl.2003.12.052
		1356	3288	99	None	-3	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
		208902	3288	99	None	-3	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
		2355	3288	99	None	-3	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
		CHEMBL1218	3288	99	None	-3	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
		DB00980	3288	99	None	-3	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
		11100761	101791	4	None	1	2	Human	10.3	pKi	=	10.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	372	4	1	3	2.5	COc1ccc2c(c1)c(CCNC(C)=O)c(I)n2C	10.1021/jm011053+
		CHEMBL300056	101791	4	None	1	2	Human	10.3	pKi	=	10.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	372	4	1	3	2.5	COc1ccc2c(c1)c(CCNC(C)=O)c(I)n2C	10.1021/jm011053+
		46885226	8072	0	None	18620	2	Human	10.3	pKi	=	10.3	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	313	8	1	3	3.3	COc1ccc(OCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
		CHEMBL1091160	8072	0	None	18620	2	Human	10.3	pKi	=	10.3	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	313	8	1	3	3.3	COc1ccc(OCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
		9927219	112322	0	None	25	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		CHEMBL329263	112322	0	None	25	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		1350	1990	0	None	1	3	Human	10.3	pKi	=	10.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm980684+
		4172142	1990	0	None	1	3	Human	10.3	pKi	=	10.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm980684+
		CHEMBL10009	1990	0	None	1	3	Human	10.3	pKi	=	10.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm980684+
		9927219	112322	0	None	25	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 mins	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.5b00982
		CHEMBL329263	112322	0	None	25	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 mins	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.5b00982
		9927219	112322	0	None	25	2	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm401343c
		CHEMBL329263	112322	0	None	25	2	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm401343c
		1350	1990	0	None	1	3	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cells	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm401343c
		4172142	1990	0	None	1	3	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cells	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm401343c
		CHEMBL10009	1990	0	None	1	3	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cells	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm401343c
		164621472	185895	0	None	-2	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	288	4	1	3	3.6	CCC(=O)NCCC1CCc2ccc3nc(C)sc3c21	10.1021/acs.jmedchem.0c01836
		CHEMBL4868554	185895	0	None	-2	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	288	4	1	3	3.6	CCC(=O)NCCC1CCc2ccc3nc(C)sc3c21	10.1021/acs.jmedchem.0c01836
		10926138	207977	0	None	57	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	349	8	1	3	4.3	C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
		CHEMBL97186	207977	0	None	57	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	349	8	1	3	4.3	C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
		9858255	208077	0	None	30	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	320	4	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1	10.1021/jm980684+
		CHEMBL9772	208077	0	None	30	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	320	4	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1	10.1021/jm980684+
		16656789	88551	0	None	63	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1cccc(N(CCNC(C)=O)c2ccccc2)c1	10.1021/jm700957j
		CHEMBL235327	88551	0	None	63	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1cccc(N(CCNC(C)=O)c2ccccc2)c1	10.1021/jm700957j
		9839199	21363	0	None	1	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
		CHEMBL131424	21363	0	None	1	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
		9904304	21145	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2cccc3ccc(OC)c1c23	10.1021/jm000922c
		CHEMBL131252	21145	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2cccc3ccc(OC)c1c23	10.1021/jm000922c
		10452167	78789	0	None	-1	2	Human	10.2	pKi	=	10.2	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	376	9	1	3	5.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2003.12.052
		CHEMBL2112690	78789	0	None	-1	2	Human	10.2	pKi	=	10.2	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	376	9	1	3	5.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2003.12.052
		145982333	166557	0	None	-1	3	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4279639	166557	0	None	-1	3	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		57781216	125847	0	None	-2	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
		CHEMBL3648356	125847	0	None	-2	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
		71533431	78	0	None	-2	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	10.1016/j.bmcl.2012.11.069
		7775	78	0	None	-2	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	10.1016/j.bmcl.2012.11.069
		CHEMBL2314259	78	0	None	-2	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	10.1016/j.bmcl.2012.11.069
		57781227	125845	0	None	6	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	244	3	1	3	2.4	CC(=O)NCCC1CCc2ccc3ncoc3c21	10.1021/acs.jmedchem.0c01836
		CHEMBL3648354	125845	0	None	6	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	244	3	1	3	2.4	CC(=O)NCCC1CCc2ccc3ncoc3c21	10.1021/acs.jmedchem.0c01836
		71508232	87073	0	None	524	2	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	351	7	1	3	3.6	CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
		CHEMBL2326200	87073	0	None	524	2	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	351	7	1	3	3.6	CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
		44272320	98602	0	None	2	2	Human	10.1	pKi	=	10.1	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	288	6	2	3	3.2	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)CC)c2O1	10.1016/j.bmcl.2003.12.052
		CHEMBL276921	98602	0	None	2	2	Human	10.1	pKi	=	10.1	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	288	6	2	3	3.2	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)CC)c2O1	10.1016/j.bmcl.2003.12.052
		127042791	138060	0	None	2	2	Human	10.1	pKi	=	10.1	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	4	1	4	2.1	COc1ccc2oc(I)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		CHEMBL3765401	138060	0	None	2	2	Human	10.1	pKi	=	10.1	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	4	1	4	2.1	COc1ccc2oc(I)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		53237950	62018	0	None	13	2	Human	10.1	pKi	=	10.1	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	314	5	2	2	3.3	CCNC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
		CHEMBL1774517	62018	0	None	13	2	Human	10.1	pKi	=	10.1	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	314	5	2	2	3.3	CCNC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
		10659603	20256	0	None	1	2	Human	10.1	pKi	=	10.1	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	4	1	2	3.0	CCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
		CHEMBL130542	20256	0	None	1	2	Human	10.1	pKi	=	10.1	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	4	1	2	3.0	CCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
		24955343	63792	0	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.6	CC(=O)NCCc1c(-c2ccccc2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
		CHEMBL1802022	63792	0	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.6	CC(=O)NCCc1c(-c2ccccc2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
		23725567	125853	0	None	-2	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	3	1	3	3.2	CC(=O)NCCC1CCc2ccc3nc(C)sc3c21	10.1021/acs.jmedchem.0c01836
		CHEMBL3648362	125853	0	None	-2	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	3	1	3	3.2	CC(=O)NCCC1CCc2ccc3nc(C)sc3c21	10.1021/acs.jmedchem.0c01836
		23725514	125849	0	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	272	4	1	3	3.1	CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
		CHEMBL3648358	125849	0	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	272	4	1	3	3.1	CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
		127026423	137819	0	None	31	3	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
		CHEMBL3759802	137819	0	None	31	3	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
		137636213	156086	0	None	8	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
		CHEMBL4062947	156086	0	None	8	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
		137647756	157944	0	None	6	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	259	4	2	3	1.7	CNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
		CHEMBL4084612	157944	0	None	6	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	259	4	2	3	1.7	CNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
		127040021	138019	0	None	24	2	Human	10.1	pKi	=	10.1	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	5	1	4	4.3	COc1ccc2oc(-c3ccc4ccccc4c3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		CHEMBL3764765	138019	0	None	24	2	Human	10.1	pKi	=	10.1	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	5	1	4	4.3	COc1ccc2oc(-c3ccc4ccccc4c3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		71540389	86415	0	None	1	2	Human	10.1	pKi	=	10.1	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	241	3	1	2	3.0	COc1ccc2ccccc2c1/C=C/NC(C)=O	10.1016/j.bmcl.2012.11.069
		CHEMBL2314257	86415	0	None	1	2	Human	10.1	pKi	=	10.1	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	241	3	1	2	3.0	COc1ccc2ccccc2c1/C=C/NC(C)=O	10.1016/j.bmcl.2012.11.069
		10515048	116811	0	None	8	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	253	4	1	1	3.4	CCCC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
		CHEMBL337882	116811	0	None	8	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	253	4	1	1	3.4	CCCC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
		9903515	22793	0	None	-9	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	3	1	2	3.0	COc1ccc2cccc3c2c1C(CNC(C)=O)CC3	10.1021/jm000922c
		CHEMBL132802	22793	0	None	-9	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	3	1	2	3.0	COc1ccc2cccc3c2c1C(CNC(C)=O)CC3	10.1021/jm000922c
		9797460	118153	0	None	-6	2	Human	10.0	pKi	=	10	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	327	6	1	3	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
		CHEMBL340832	118153	0	None	-6	2	Human	10.0	pKi	=	10	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	327	6	1	3	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
		44264769	96997	0	None	10	2	Human	10.0	pKi	=	10	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	298	6	1	3	4.2	CCCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL266549	96997	0	None	10	2	Human	10.0	pKi	=	10	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	298	6	1	3	4.2	CCCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		145982070	166475	0	None	-1	2	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	283	3	1	2	3.2	COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
		CHEMBL4278248	166475	0	None	-1	2	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	283	3	1	2	3.2	COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
		145981162	166497	0	None	3	3	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	270	3	2	2	2.5	COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3	10.1016/j.ejmech.2017.10.025
		CHEMBL4278575	166497	0	None	3	3	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	270	3	2	2	2.5	COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3	10.1016/j.ejmech.2017.10.025
		145982167	166611	0	None	7	3	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	305	4	1	3	2.4	COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
		CHEMBL4280601	166611	0	None	7	3	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	305	4	1	3	2.4	COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
		145979282	166675	0	None	16	3	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4281915	166675	0	None	16	3	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		145987794	167120	0	None	19	3	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	298	4	2	2	3.2	CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4290302	167120	0	None	19	3	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	298	4	2	2	3.2	CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		145988741	167236	0	None	6	3	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	299	5	1	3	2.6	COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4292336	167236	0	None	6	3	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	299	5	1	3	2.6	COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		137655238	158885	0	None	19	2	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
		CHEMBL4095210	158885	0	None	19	2	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
		198	313	126	None	1	6	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
		82148	313	126	None	1	6	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
		99	313	126	None	1	6	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
		CHEMBL10878	313	126	None	1	6	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
		DB06594	313	126	None	1	6	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
		24750071	98920	0	None	39	2	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	312	8	1	3	3.8	CCCC(=O)NCCN(c1ccccc1)c1cccc(OC)c1	10.1021/jm700957j
		CHEMBL279401	98920	0	None	39	2	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	312	8	1	3	3.8	CCCC(=O)NCCN(c1ccccc1)c1cccc(OC)c1	10.1021/jm700957j
		9839199	21363	0	None	1	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
		CHEMBL131424	21363	0	None	1	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
		10385056	112236	0	None	194	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
		CHEMBL329086	112236	0	None	194	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
		44581851	175211	0	None	1202	2	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	333	6	1	2	4.5	COc1cccc(C(CCNC(C)=O)c2ccc3ccccc3c2)c1	10.1021/jm800974d
		CHEMBL457128	175211	0	None	1202	2	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	333	6	1	2	4.5	COc1cccc(C(CCNC(C)=O)c2ccc3ccccc3c2)c1	10.1021/jm800974d
		10385056	112236	0	None	194	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm401343c
		CHEMBL329086	112236	0	None	194	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm401343c
		1356	3288	99	None	-3	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human MT2 expressed in CHO cellsBinding affinity to human MT2 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
		208902	3288	99	None	-3	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human MT2 expressed in CHO cellsBinding affinity to human MT2 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
		2355	3288	99	None	-3	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human MT2 expressed in CHO cellsBinding affinity to human MT2 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
		CHEMBL1218	3288	99	None	-3	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human MT2 expressed in CHO cellsBinding affinity to human MT2 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
		DB00980	3288	99	None	-3	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human MT2 expressed in CHO cellsBinding affinity to human MT2 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
		24750189	89480	0	None	1174	2	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	334	6	1	3	4.1	COc1cccc(N(CCNC(C)=O)c2ccc3ccccc3c2)c1	10.1021/jm700957j
		CHEMBL237234	89480	0	None	1174	2	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	334	6	1	3	4.1	COc1cccc(N(CCNC(C)=O)c2ccc3ccccc3c2)c1	10.1021/jm700957j
		10562968	20195	0	None	-1	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	255	3	1	2	2.6	COc1ccc2cccc3c2c1C(CNC(C)=O)C3	10.1021/jm000922c
		CHEMBL130490	20195	0	None	-1	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	255	3	1	2	2.6	COc1ccc2cccc3c2c1C(CNC(C)=O)C3	10.1021/jm000922c
		44264818	205225	0	None	91	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	283	6	1	2	4.0	CCCC(=O)Nc1ccc(Cc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL7867	205225	0	None	91	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	283	6	1	2	4.0	CCCC(=O)Nc1ccc(Cc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		10712733	208442	0	None	48	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	5	1	3	3.9	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1021/jm980684+
		CHEMBL9997	208442	0	None	48	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	5	1	3	3.9	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1021/jm980684+
		1357	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
		1672	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
		224	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
		896	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
		CHEMBL45	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
		DB01065	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
		57781240	185988	0	None	36	2	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	334	5	1	3	4.0	CC(=O)NCCC1CCc2ccc3nc(Cc4ccccc4)oc3c21	10.1021/acs.jmedchem.0c01836
		CHEMBL4870108	185988	0	None	36	2	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	334	5	1	3	4.0	CC(=O)NCCC1CCc2ccc3nc(Cc4ccccc4)oc3c21	10.1021/acs.jmedchem.0c01836
		1357	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
		1672	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
		224	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
		896	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
		CHEMBL45	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
		DB01065	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
		9817262	19484	0	None	1	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	CCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
		CHEMBL129889	19484	0	None	1	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	CCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
		44272410	68016	0	None	7	2	Human	9.9	pKi	=	9.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	274	5	2	3	2.9	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1	10.1016/j.bmcl.2003.12.052
		CHEMBL19128	68016	0	None	7	2	Human	9.9	pKi	=	9.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	274	5	2	3	2.9	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1	10.1016/j.bmcl.2003.12.052
		23725565	125846	0	None	-1	2	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCCC1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
		CHEMBL3648355	125846	0	None	-1	2	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCCC1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
		1357	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
		1672	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
		224	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
		896	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
		CHEMBL45	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
		DB01065	2485	139	None	1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
		44272317	98913	0	None	1	2	Human	9.9	pKi	=	9.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	300	6	2	3	3.2	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1	10.1016/j.bmcl.2003.12.052
		CHEMBL279343	98913	0	None	1	2	Human	9.9	pKi	=	9.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	300	6	2	3	3.2	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1	10.1016/j.bmcl.2003.12.052
		53310841	63797	0	None	-5	2	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	299	5	1	4	2.2	CCC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
		CHEMBL1802028	63797	0	None	-5	2	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	299	5	1	4	2.2	CCC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
		127042142	138075	0	None	-3	2	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	310	5	1	4	3.2	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		CHEMBL3765540	138075	0	None	-3	2	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	310	5	1	4	3.2	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		9926304	116575	0	None	-9	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	299	4	1	3	3.0	COc1ccc2ccc(OC)c3c2c1CCC3CNC(C)=O	10.1021/jm000922c
		CHEMBL336509	116575	0	None	-9	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	299	4	1	3	3.0	COc1ccc2ccc(OC)c3c2c1CCC3CNC(C)=O	10.1021/jm000922c
		115348	70	47	None	-4	2	Human	9.8	pKi	=	9.8	Binding	Compound was tested for binding affinity against human Melatonin receptor type 1B in CHO cellsCompound was tested for binding affinity against human Melatonin receptor type 1B in CHO cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1016/S0960-894X(97)00444-7
		1343	70	47	None	-4	2	Human	9.8	pKi	=	9.8	Binding	Compound was tested for binding affinity against human Melatonin receptor type 1B in CHO cellsCompound was tested for binding affinity against human Melatonin receptor type 1B in CHO cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1016/S0960-894X(97)00444-7
		CHEMBL289233	70	47	None	-4	2	Human	9.8	pKi	=	9.8	Binding	Compound was tested for binding affinity against human Melatonin receptor type 1B in CHO cellsCompound was tested for binding affinity against human Melatonin receptor type 1B in CHO cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1016/S0960-894X(97)00444-7
		DB08190	70	47	None	-4	2	Human	9.8	pKi	=	9.8	Binding	Compound was tested for binding affinity against human Melatonin receptor type 1B in CHO cellsCompound was tested for binding affinity against human Melatonin receptor type 1B in CHO cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1016/S0960-894X(97)00444-7
		1357	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
		1672	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
		224	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
		896	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
		CHEMBL45	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
		DB01065	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
		1357	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
		1672	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
		224	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
		896	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
		CHEMBL45	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
		DB01065	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
		57781246	125857	0	None	2	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	284	4	1	3	3.3	CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21	10.1021/acs.jmedchem.0c01836
		CHEMBL3648366	125857	0	None	2	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	284	4	1	3	3.3	CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21	10.1021/acs.jmedchem.0c01836
		23725612	125858	0	None	2	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	4	1	4	2.4	COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	10.1021/acs.jmedchem.0c01836
		CHEMBL3648367	125858	0	None	2	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	4	1	4	2.4	COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	10.1021/acs.jmedchem.0c01836
		9796846	116436	0	None	-12	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	313	5	1	3	3.4	CCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
		CHEMBL336054	116436	0	None	-12	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	313	5	1	3	3.4	CCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
		10522674	207761	0	None	56	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	7	1	3	4.5	CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)Cc1ccccc1-2	10.1021/jm980684+
		CHEMBL9590	207761	0	None	56	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	7	1	3	4.5	CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)Cc1ccccc1-2	10.1021/jm980684+
		10244841	67495	1	None	8	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	309	4	1	2	3.5	CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm800974d
		CHEMBL189414	67495	1	None	8	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	309	4	1	2	3.5	CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm800974d
		23725515	125856	0	None	1	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	272	4	1	3	2.9	CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	10.1021/acs.jmedchem.0c01836
		CHEMBL3648365	125856	0	None	1	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	272	4	1	3	2.9	CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	10.1021/acs.jmedchem.0c01836
		115348	70	47	None	-4	2	Human	9.8	pKi	=	9.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm011053+
		1343	70	47	None	-4	2	Human	9.8	pKi	=	9.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm011053+
		CHEMBL289233	70	47	None	-4	2	Human	9.8	pKi	=	9.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm011053+
		DB08190	70	47	None	-4	2	Human	9.8	pKi	=	9.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm011053+
		10244841	67495	1	None	8	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	309	4	1	2	3.5	CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm040768k
		CHEMBL189414	67495	1	None	8	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	309	4	1	2	3.5	CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm040768k
		44264892	205180	0	None	5	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	284	5	1	3	3.8	CCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL7832	205180	0	None	5	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	284	5	1	3	3.8	CCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		9840647	98221	0	None	25	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	5	1	3	3.7	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)Cc1ccccc1-2	10.1021/jm980684+
		CHEMBL274317	98221	0	None	25	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	5	1	3	3.7	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)Cc1ccccc1-2	10.1021/jm980684+
		11079938	193857	4	None	1	2	Human	9.8	pKi	=	9.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	403	5	2	4	2.4	COc1cc2c(CCNC(C)=O)c(I)[nH]c2cc1[N+](=O)[O-]	10.1021/jm011053+
		CHEMBL52755	193857	4	None	1	2	Human	9.8	pKi	=	9.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	403	5	2	4	2.4	COc1cc2c(CCNC(C)=O)c(I)[nH]c2cc1[N+](=O)[O-]	10.1021/jm011053+
		1357	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
		1672	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
		224	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
		896	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
		CHEMBL45	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
		DB01065	2485	139	None	1	9	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
		9916005	32712	0	None	-3	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	568	17	2	4	7.1	CC(=O)NCCc1cccc2ccc(OCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
		CHEMBL14136	32712	0	None	-3	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	568	17	2	4	7.1	CC(=O)NCCc1cccc2ccc(OCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
		44353165	116914	0	None	7	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	267	4	1	1	3.8	CCCC(=O)NCC1CCc2cccc3cccc1c23	10.1021/jm000922c
		CHEMBL338425	116914	0	None	7	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	267	4	1	1	3.8	CCCC(=O)NCC1CCc2cccc3cccc1c23	10.1021/jm000922c
		1357	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		1672	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		224	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		896	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		CHEMBL45	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		DB01065	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		1357	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		1672	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		224	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		896	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		CHEMBL45	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		DB01065	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		9798080	19485	0	None	-3	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	341	7	1	3	4.2	CCCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
		CHEMBL129890	19485	0	None	-3	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	341	7	1	3	4.2	CCCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
		15453821	205105	0	None	151	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	301	6	1	3	4.6	CCCC(=O)Nc1ccc(Sc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL7771	205105	0	None	151	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	301	6	1	3	4.6	CCCC(=O)Nc1ccc(Sc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		10016733	78799	0	None	-3	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	284	5	1	3	3.0	CCc1nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2003.12.052
		CHEMBL2112724	78799	0	None	-3	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	284	5	1	3	3.0	CCc1nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2003.12.052
		56653119	171792	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	322	7	2	2	3.5	CC(=O)NCCc1c[nH]c2ccc(OCCc3ccccc3)cc12	10.1016/j.ejmech.2019.111847
		CHEMBL4467954	171792	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	322	7	2	2	3.5	CC(=O)NCCc1c[nH]c2ccc(OCCc3ccccc3)cc12	10.1016/j.ejmech.2019.111847
		53310839	63794	0	None	-2	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.6	CCC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3	10.1021/jm200385u
		CHEMBL1802024	63794	0	None	-2	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.6	CCC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3	10.1021/jm200385u
		1357	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
		1672	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
		224	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
		896	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
		CHEMBL45	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
		DB01065	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
		24750191	88552	0	None	85	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	332	5	1	2	3.7	CC(=O)NCCN(c1ccccc1)c1cccc(Br)c1	10.1021/jm700957j
		CHEMBL235328	88552	0	None	85	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	332	5	1	2	3.7	CC(=O)NCCN(c1ccccc1)c1cccc(Br)c1	10.1021/jm700957j
		11810280	207931	0	None	16	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	8	1	3	4.5	CCCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
		CHEMBL96859	207931	0	None	16	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	8	1	3	4.5	CCCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
		1346	160	47	None	25	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1016/j.ejmech.2019.111847
		1858	160	47	None	25	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1016/j.ejmech.2019.111847
		CHEMBL34730	160	47	None	25	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1016/j.ejmech.2019.111847
		10522675	4338	0	None	20	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	6	1	3	4.3	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1021/jm980684+
		CHEMBL10099	4338	0	None	20	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	6	1	3	4.3	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1021/jm980684+
		10522675	4338	0	None	20	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	362	6	1	3	4.3	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1016/j.ejmech.2019.111847
		CHEMBL10099	4338	0	None	20	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	362	6	1	3	4.3	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1016/j.ejmech.2019.111847
		198	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
		82148	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
		99	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
		CHEMBL10878	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
		DB06594	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
		145982333	166557	0	None	-1	3	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4279639	166557	0	None	-1	3	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		145979689	166623	0	None	5	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	314	3	2	2	3.1	CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4280791	166623	0	None	5	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	314	3	2	2	3.1	CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		145981769	166667	0	None	1	3	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	270	3	1	3	2.4	COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
		CHEMBL4281712	166667	0	None	1	3	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	270	3	1	3	2.4	COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
		145993214	166751	0	None	5	3	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	285	3	2	3	2.2	CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4283539	166751	0	None	5	3	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	285	3	2	3	2.2	CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
		145993188	167022	0	None	3	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	319	4	1	3	2.6	COc1ccc2ccc3c(c2c1)C(C)(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
		CHEMBL4288497	167022	0	None	3	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	319	4	1	3	2.6	COc1ccc2ccc3c(c2c1)C(C)(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
		145988269	167190	0	None	10	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	326	5	2	2	3.8	CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4291381	167190	0	None	10	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	326	5	2	2	3.8	CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		145986532	167281	0	None	1	3	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	269	3	1	2	3.0	COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
		CHEMBL4293386	167281	0	None	1	3	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	269	3	1	2	3.0	COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
		145993566	167371	0	None	25	3	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	312	5	2	2	3.6	CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4294790	167371	0	None	25	3	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	312	5	2	2	3.6	CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		198	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
		82148	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
		99	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
		CHEMBL10878	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
		DB06594	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
		137639112	156852	0	None	10	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	245	4	2	3	1.5	COc1ccc2cccc(CCNC(N)=O)c2n1	10.1016/j.ejmech.2016.12.013
		CHEMBL4071572	156852	0	None	10	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	245	4	2	3	1.5	COc1ccc2cccc(CCNC(N)=O)c2n1	10.1016/j.ejmech.2016.12.013
		137660333	159520	0	None	1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1ccc2cccc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.12.013
		CHEMBL4102177	159520	0	None	1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1ccc2cccc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.12.013
		56659223	64989	0	None	-5	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	2	3	2.9	COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2011.06.030
		CHEMBL1823015	64989	0	None	-5	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	2	3	2.9	COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2011.06.030
		1346	160	47	None	25	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1021/jm401343c
		1858	160	47	None	25	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1021/jm401343c
		CHEMBL34730	160	47	None	25	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1021/jm401343c
		15453090	86412	0	None	-3	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	285	4	1	3	2.8	COc1ccc2ccc(OC)c([C@@H]3C[C@H]3NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
		CHEMBL2314253	86412	0	None	-3	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	285	4	1	3	2.8	COc1ccc2ccc(OC)c([C@@H]3C[C@H]3NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
		11110447	207789	0	None	4	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	6	1	3	4.3	C/C=C/C(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
		CHEMBL96104	207789	0	None	4	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	6	1	3	4.3	C/C=C/C(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
		10854190	98313	0	None	87	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	5	1	3	3.7	CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1	10.1021/jm980684+
		CHEMBL274896	98313	0	None	87	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	5	1	3	3.7	CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1	10.1021/jm980684+
		198	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
		82148	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
		99	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
		CHEMBL10878	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
		DB06594	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
		1357	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
		1672	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
		224	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
		896	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
		CHEMBL45	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
		DB01065	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
		1357	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
		1672	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
		224	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
		896	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
		CHEMBL45	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
		DB01065	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
		198	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
		82148	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
		99	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
		CHEMBL10878	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
		DB06594	313	126	None	1	6	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
		1357	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
		1672	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
		224	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
		896	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
		CHEMBL45	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
		DB01065	2485	139	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
		16094584	83245	0	None	33	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
		CHEMBL218708	83245	0	None	33	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
		10752506	19986	0	None	5	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	2	1	1	3.0	CC(=O)NCC1CCc2cccc3cccc1c23	10.1021/jm000922c
		CHEMBL130319	19986	0	None	5	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	2	1	1	3.0	CC(=O)NCC1CCc2cccc3cccc1c23	10.1021/jm000922c
		10561982	23022	0	None	12	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	3	1	1	3.0	CCC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
		CHEMBL133001	23022	0	None	12	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	3	1	1	3.0	CCC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
		11002840	207527	0	None	33	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	357	6	1	3	4.4	COc1ccc2oc(Cc3cccc(Cl)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		CHEMBL94607	207527	0	None	33	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	357	6	1	3	4.4	COc1ccc2oc(Cc3cccc(Cl)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		137648419	157839	0	None	15	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	293	4	1	1	3.9	CCC(=O)NC[C@@H]1CCc2ccccc2[C@@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
		CHEMBL4083618	157839	0	None	15	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	293	4	1	1	3.9	CCC(=O)NC[C@@H]1CCc2ccccc2[C@@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
		24954990	63795	0	None	-5	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	287	5	1	4	1.9	CCC(=O)NCCc1c(CC)nn2ccc3c(c12)CCO3	10.1021/jm200385u
		CHEMBL1802026	63795	0	None	-5	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	287	5	1	4	1.9	CCC(=O)NCCc1c(CC)nn2ccc3c(c12)CCO3	10.1021/jm200385u
		115348	70	47	None	-4	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm401343c
		1343	70	47	None	-4	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm401343c
		CHEMBL289233	70	47	None	-4	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm401343c
		DB08190	70	47	None	-4	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm401343c
		1357	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
		1672	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
		224	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
		896	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
		CHEMBL45	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
		DB01065	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
		9884406	207626	0	None	3	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	341	6	1	3	3.9	COc1ccc2oc(Cc3cccc(F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		CHEMBL95166	207626	0	None	3	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	341	6	1	3	3.9	COc1ccc2oc(Cc3cccc(F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		44264903	205618	0	None	-4	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	270	4	1	3	3.4	COc1cccc(N(C)c2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
		CHEMBL8168	205618	0	None	-4	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	270	4	1	3	3.4	COc1cccc(N(C)c2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
		137637541	155998	0	None	269	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	293	4	1	1	3.9	CCC(=O)NC[C@@H]1CCc2ccccc2[C@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
		CHEMBL4061850	155998	0	None	269	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	293	4	1	1	3.9	CCC(=O)NC[C@@H]1CCc2ccccc2[C@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
		57781208	185621	0	None	5	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	320	4	1	3	4.1	CC(=O)NCCC1CCc2ccc3nc(-c4ccccc4)oc3c21	10.1021/acs.jmedchem.0c01836
		CHEMBL4864102	185621	0	None	5	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	320	4	1	3	4.1	CC(=O)NCCC1CCc2ccc3nc(-c4ccccc4)oc3c21	10.1021/acs.jmedchem.0c01836
		1357	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
		1672	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
		224	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
		896	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
		CHEMBL45	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
		DB01065	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
		10540964	116628	0	None	-1	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
		CHEMBL336858	116628	0	None	-1	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
		44272316	67600	0	None	-4	2	Human	9.6	pKi	=	9.6	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	392	10	2	3	5.3	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2	10.1016/j.bmcl.2003.12.052
		CHEMBL19026	67600	0	None	-4	2	Human	9.6	pKi	=	9.6	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	392	10	2	3	5.3	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2	10.1016/j.bmcl.2003.12.052
		139451781	184858	0	None	1	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
		CHEMBL4852440	184858	0	None	1	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
		52953165	62408	0	None	218	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	389	7	1	3	5.6	C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
		CHEMBL1779810	62408	0	None	218	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	389	7	1	3	5.6	C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
		10019103	67493	0	None	5	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	323	5	1	2	3.8	CCCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm040768k
		CHEMBL189395	67493	0	None	5	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	323	5	1	2	3.8	CCCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm040768k
		129776	142	6	None	128	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1016/j.ejmech.2019.111847
		1364	142	6	None	128	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1016/j.ejmech.2019.111847
		CHEMBL339105	142	6	None	128	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1016/j.ejmech.2019.111847
		1353	3435	5	None	112	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm800974d
		9998187	3435	5	None	112	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm800974d
		CHEMBL33549	3435	5	None	112	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm800974d
		129776	142	6	None	128	2	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1021/jm401343c
		1364	142	6	None	128	2	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1021/jm401343c
		CHEMBL339105	142	6	None	128	2	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1021/jm401343c
		1357	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
		1672	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
		224	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
		896	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
		CHEMBL45	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
		DB01065	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
		9840277	23563	0	None	-10	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	325	5	1	3	3.4	COc1ccc2ccc(OC)c3c2c1CCC3CNC(=O)C1CC1	10.1021/jm000922c
		CHEMBL133416	23563	0	None	-10	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	325	5	1	3	3.4	COc1ccc2ccc(OC)c3c2c1CCC3CNC(=O)C1CC1	10.1021/jm000922c
		10617720	207819	0	None	56	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2Cc2ccccc2-1	10.1021/jm980684+
		CHEMBL9630	207819	0	None	56	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2Cc2ccccc2-1	10.1021/jm980684+
		198	313	126	None	1	6	Human	9.6	pKi	=	9.6	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
		82148	313	126	None	1	6	Human	9.6	pKi	=	9.6	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
		99	313	126	None	1	6	Human	9.6	pKi	=	9.6	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
		CHEMBL10878	313	126	None	1	6	Human	9.6	pKi	=	9.6	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
		DB06594	313	126	None	1	6	Human	9.6	pKi	=	9.6	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
		198	313	126	None	1	6	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
		82148	313	126	None	1	6	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
		99	313	126	None	1	6	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
		CHEMBL10878	313	126	None	1	6	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
		DB06594	313	126	None	1	6	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
		1354	3436	15	None	275	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	10.1016/j.bmc.2008.08.052
		22133318	3436	15	None	275	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	10.1016/j.bmc.2008.08.052
		CHEMBL490188	3436	15	None	275	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	10.1016/j.bmc.2008.08.052
		11644612	78298	0	None	9	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
		CHEMBL210791	78298	0	None	9	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
		16094586	83148	4	None	213	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	311	6	1	3	3.3	COc1cccc(C(=CCNC(C)=O)c2cccc(OC)c2)c1	10.1021/jm060850a
		CHEMBL218225	83148	4	None	213	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	311	6	1	3	3.3	COc1cccc(C(=CCNC(C)=O)c2cccc(OC)c2)c1	10.1021/jm060850a
		44272334	67635	0	None	17	2	Human	9.6	pKi	=	9.6	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	302	6	2	3	3.5	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1	10.1016/j.bmcl.2003.12.052
		CHEMBL19050	67635	0	None	17	2	Human	9.6	pKi	=	9.6	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	302	6	2	3	3.5	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1	10.1016/j.bmcl.2003.12.052
		139451763	186333	0	None	1	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	305	8	1	5	2.4	CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21	10.1021/acs.jmedchem.0c00627
		CHEMBL4874954	186333	0	None	1	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	305	8	1	5	2.4	CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21	10.1021/acs.jmedchem.0c00627
		52918078	60754	0	None	11	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	247	5	1	4	1.6	CCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
		CHEMBL1760946	60754	0	None	11	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	247	5	1	4	1.6	CCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
		53310840	63796	0	None	-6	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	285	4	1	4	1.8	CC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
		CHEMBL1802027	63796	0	None	-6	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	285	4	1	4	1.8	CC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
		12985495	181386	0	None	213	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	8	2	3	4.5	CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
		CHEMBL476341	181386	0	None	213	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	8	2	3	4.5	CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
		1357	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
		1672	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
		224	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
		896	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
		CHEMBL45	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
		DB01065	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
		1357	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
		1672	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
		224	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
		896	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
		CHEMBL45	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
		DB01065	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
		1357	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
		1672	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
		224	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
		896	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
		CHEMBL45	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
		DB01065	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
		46865422	87071	0	None	575	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
		CHEMBL2326199	87071	0	None	575	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
		137641357	157079	0	None	3	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
		CHEMBL4074273	157079	0	None	3	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
		21581654	60752	1	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		CHEMBL1760944	60752	1	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		52918079	60755	0	None	4	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	261	6	1	4	2.0	CCCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
		CHEMBL1760947	60755	0	None	4	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	261	6	1	4	2.0	CCCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
		145979282	166675	0	None	16	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4281915	166675	0	None	16	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		145992795	166791	0	None	29	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	342	5	2	2	3.9	CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4284223	166791	0	None	29	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	342	5	2	2	3.9	CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		145990662	166929	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	312	4	2	2	3.4	CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4286896	166929	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	312	4	2	2	3.4	CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		137636173	156001	0	None	63	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	276	6	1	3	2.3	COc1ccc2cccc(CCC(=O)NCCF)c2n1	10.1016/j.ejmech.2016.12.013
		CHEMBL4061905	156001	0	None	63	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	276	6	1	3	2.3	COc1ccc2cccc(CCC(=O)NCCF)c2n1	10.1016/j.ejmech.2016.12.013
		137650611	157512	0	None	26	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	CNC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
		CHEMBL4079784	157512	0	None	26	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	CNC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
		137645530	157723	0	None	23	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	260	4	1	4	2.1	COC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
		CHEMBL4082097	157723	0	None	23	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	260	4	1	4	2.1	COC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
		71540396	86417	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	286	4	2	3	2.8	CNC(=O)N/C=C/c1c(OC)ccc2ccc(OC)cc12	10.1016/j.bmcl.2012.11.069
		CHEMBL2314260	86417	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	286	4	2	3	2.8	CNC(=O)N/C=C/c1c(OC)ccc2ccc(OC)cc12	10.1016/j.bmcl.2012.11.069
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		44358146	27077	0	None	-2	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	274	4	1	3	2.1	CCCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		CHEMBL136531	27077	0	None	-2	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	274	4	1	3	2.1	CCCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		10850411	115357	0	None	4	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	281	4	1	2	3.0	COc1ccc2cccc3c2c1C(CNC(=O)C1CC1)C3	10.1021/jm000922c
		CHEMBL334962	115357	0	None	4	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	281	4	1	2	3.0	COc1ccc2cccc3c2c1C(CNC(=O)C1CC1)C3	10.1021/jm000922c
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
		23658146	157118	1	None	10	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
		CHEMBL4074895	157118	1	None	10	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
		1353	3435	5	None	112	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
		9998187	3435	5	None	112	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
		CHEMBL33549	3435	5	None	112	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
		44272430	166932	0	None	15	2	Human	9.5	pKi	=	9.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	288	5	2	3	3.1	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
		CHEMBL428692	166932	0	None	15	2	Human	9.5	pKi	=	9.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	288	5	2	3	3.1	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
		1353	3435	5	None	112	2	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm048956y
		9998187	3435	5	None	112	2	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm048956y
		CHEMBL33549	3435	5	None	112	2	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm048956y
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
		10446712	78798	0	None	-6	2	Human	9.5	pKi	=	9.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	286	6	1	3	3.4	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12	10.1016/j.bmcl.2003.12.052
		CHEMBL2112722	78798	0	None	-6	2	Human	9.5	pKi	=	9.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	286	6	1	3	3.4	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12	10.1016/j.bmcl.2003.12.052
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		53310987	63799	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	327	4	1	4	2.4	CCC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3	10.1021/jm200385u
		CHEMBL1802030	63799	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	327	4	1	4	2.4	CCC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3	10.1021/jm200385u
		1353	3435	5	None	112	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm401343c
		9998187	3435	5	None	112	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm401343c
		CHEMBL33549	3435	5	None	112	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm401343c
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
		71508235	87075	0	None	95	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	327	8	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1	10.1016/j.bmc.2012.10.060
		CHEMBL2326203	87075	0	None	95	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	327	8	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1	10.1016/j.bmc.2012.10.060
		10661735	168324	0	None	1	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	6	1	2	3.8	CCCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
		CHEMBL434226	168324	0	None	1	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	6	1	2	3.8	CCCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
		10059864	109823	5	None	-2	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm0005252
		CHEMBL323332	109823	5	None	-2	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm0005252
		11824364	112552	0	None	42	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		CHEMBL329960	112552	0	None	42	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
		10059864	109823	5	None	-2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.ejmech.2015.12.047
		CHEMBL323332	109823	5	None	-2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.ejmech.2015.12.047
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
		53238409	62027	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	377	6	1	3	4.4	CC(=O)NCCC1=C(c2ccccc2OC(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
		CHEMBL1774528	62027	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	377	6	1	3	4.4	CC(=O)NCCC1=C(c2ccccc2OC(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
		10059864	109823	5	None	-2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.ejmech.2016.01.008
		CHEMBL323332	109823	5	None	-2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.ejmech.2016.01.008
		122220128	159675	0	None	5	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	6	2	3	2.3	COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1	10.1039/C4MD00149D
		CHEMBL4104020	159675	0	None	5	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	6	2	3	2.3	COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1	10.1039/C4MD00149D
		18466111	19845	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
		CHEMBL130214	19845	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
		10882307	207474	0	None	15	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	338	6	2	3	3.5	CNC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
		CHEMBL94301	207474	0	None	15	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	338	6	2	3	3.5	CNC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
		25024912	185919	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	4	1	3	2.5	CCC(=O)NCCC1CCc2ccc3nn(C)cc3c21	10.1021/acs.jmedchem.0c01836
		CHEMBL4869029	185919	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	4	1	3	2.5	CCC(=O)NCCC1CCc2ccc3nn(C)cc3c21	10.1021/acs.jmedchem.0c01836
		16750569	87362	0	None	14	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	338	6	2	2	3.4	CCCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		CHEMBL233308	87362	0	None	14	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	338	6	2	2	3.4	CCCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		1357	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
		1672	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
		224	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
		896	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
		CHEMBL45	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
		DB01065	2485	139	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
		7922	1956	0	None	741	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	10.1016/j.bmc.2008.08.052
		9798456	1956	0	None	741	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	10.1016/j.bmc.2008.08.052
		CHEMBL476131	1956	0	None	741	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	10.1016/j.bmc.2008.08.052
		21581654	60752	1	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2011.06.030
		CHEMBL1760944	60752	1	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2011.06.030
		21581654	60752	1	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		CHEMBL1760944	60752	1	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		9998754	78794	0	None	-7	2	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	362	8	1	3	4.6	CC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2003.12.052
		CHEMBL2112700	78794	0	None	-7	2	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	362	8	1	3	4.6	CC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2003.12.052
		9818487	173533	0	None	141	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	319	5	1	2	4.2	COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		CHEMBL453138	173533	0	None	141	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	319	5	1	2	4.2	COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		139451764	186267	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
		CHEMBL4873903	186267	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
		10016919	100610	1	None	-3	2	Human	9.4	pKi	=	9.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	287	6	1	3	2.9	CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
		CHEMBL291857	100610	1	None	-3	2	Human	9.4	pKi	=	9.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	287	6	1	3	2.9	CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
		10016919	100610	1	None	-3	2	Human	9.4	pKi	=	9.4	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells	ChEMBL	287	6	1	3	2.9	CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12	10.1021/jm970437q
		CHEMBL291857	100610	1	None	-3	2	Human	9.4	pKi	=	9.4	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells	ChEMBL	287	6	1	3	2.9	CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12	10.1021/jm970437q
		198	313	126	None	1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
		82148	313	126	None	1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
		99	313	126	None	1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
		CHEMBL10878	313	126	None	1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
		DB06594	313	126	None	1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
		9925797	22252	0	None	-3	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	COc1ccc2cccc3c2c1C(CCNC(C)=O)CC3	10.1021/jm000922c
		CHEMBL132340	22252	0	None	-3	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	COc1ccc2cccc3c2c1C(CCNC(C)=O)CC3	10.1021/jm000922c
		44264705	204461	1	None	79	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	284	6	2	3	4.2	CCCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL7229	204461	1	None	79	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	284	6	2	3	4.2	CCCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		44358196	119286	0	None	-2	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	260	3	1	3	1.7	CCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		CHEMBL343825	119286	0	None	-2	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	260	3	1	3	1.7	CCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		127026062	137689	0	None	5	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
		CHEMBL3758717	137689	0	None	5	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
		145979585	166490	0	None	17	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	313	5	2	3	3.0	CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4278446	166490	0	None	17	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	313	5	2	3	3.0	CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
		145991966	166836	0	None	5	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	285	3	1	3	3.2	COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4285145	166836	0	None	5	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	285	3	1	3	3.2	COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		145991111	166912	0	None	17	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	319	5	1	3	2.8	CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4286494	166912	0	None	17	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	319	5	1	3	2.8	CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		145986330	167057	0	None	15	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	286	3	2	2	2.7	COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3	10.1016/j.ejmech.2017.10.025
		CHEMBL4289115	167057	0	None	15	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	286	3	2	2	2.7	COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3	10.1016/j.ejmech.2017.10.025
		137650826	157505	0	None	10	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
		CHEMBL4079699	157505	0	None	10	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
		10333442	203886	0	None	5	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	272	6	1	3	2.7	CCCC(=O)NCCc1ccnc2ccc(OC)cc12	10.1016/S0960-894X(97)00392-2
		CHEMBL68864	203886	0	None	5	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	272	6	1	3	2.7	CCCC(=O)NCCc1ccnc2ccc(OC)cc12	10.1016/S0960-894X(97)00392-2
		1357	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
		1672	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
		224	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
		896	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
		CHEMBL45	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
		DB01065	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
		10199282	116593	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	3	1	2	3.0	COc1ccc2cccc3c2c1CCC3CNC(C)=O	10.1021/jm000922c
		CHEMBL336647	116593	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	3	1	2	3.0	COc1ccc2cccc3c2c1CCC3CNC(C)=O	10.1021/jm000922c
		11733059	111654	0	None	21	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	449	7	1	3	4.1	COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)CI)c2c1	10.1021/jm0005252
		CHEMBL328617	111654	0	None	21	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	449	7	1	3	4.1	COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)CI)c2c1	10.1021/jm0005252
		1357	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
		1672	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
		224	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
		896	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
		CHEMBL45	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
		DB01065	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
		1357	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
		1672	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
		224	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
		896	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
		CHEMBL45	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
		DB01065	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
		11644612	78298	0	None	9	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
		CHEMBL210791	78298	0	None	9	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
		10468642	27118	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	275	3	2	3	1.5	CCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		CHEMBL136564	27118	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	275	3	2	3	1.5	CCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		24954989	1532	1	None	-6	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
		7774	1532	1	None	-6	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
		CHEMBL1802025	1532	1	None	-6	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
		44579259	187114	0	None	331	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	347	6	1	3	4.0	COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		CHEMBL491604	187114	0	None	331	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	347	6	1	3	4.0	COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		1357	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
		1672	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
		224	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
		896	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
		CHEMBL45	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
		DB01065	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
		1357	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
		1672	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
		224	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
		896	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
		CHEMBL45	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
		DB01065	2485	139	None	1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
		10423378	78800	0	None	-8	2	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	272	5	1	3	3.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12	10.1016/j.bmcl.2003.12.052
		CHEMBL2112727	78800	0	None	-8	2	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	272	5	1	3	3.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12	10.1016/j.bmcl.2003.12.052
		198	313	126	None	1	6	Human	9.4	pKi	=	9.4	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
		82148	313	126	None	1	6	Human	9.4	pKi	=	9.4	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
		99	313	126	None	1	6	Human	9.4	pKi	=	9.4	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
		CHEMBL10878	313	126	None	1	6	Human	9.4	pKi	=	9.4	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
		DB06594	313	126	None	1	6	Human	9.4	pKi	=	9.4	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
		86273228	121320	0	None	5	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	258	6	2	2	2.4	C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
		CHEMBL3580910	121320	0	None	5	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	258	6	2	2	2.4	C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
		1358	124	41	None	870	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm800974d
		3976006	124	41	None	870	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm800974d
		CHEMBL285718	124	41	None	870	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm800974d
		11652196	138313	0	None	9	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	288	6	1	3	3.2	CCCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
		CHEMBL377101	138313	0	None	9	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	288	6	1	3	3.2	CCCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
		11741001	78804	0	None	-9	2	Human	9.3	pKi	=	9.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	388	9	1	3	5.0	O=C(NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2003.12.052
		CHEMBL2112734	78804	0	None	-9	2	Human	9.3	pKi	=	9.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	388	9	1	3	5.0	O=C(NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2003.12.052
		137631636	156608	0	None	7	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	308	4	1	2	3.4	CCC(=O)NC[C@@H]1CN(C)c2ccccc2[C@@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
		CHEMBL4068887	156608	0	None	7	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	308	4	1	2	3.4	CCC(=O)NC[C@@H]1CN(C)c2ccccc2[C@@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
		44264861	205144	0	None	74	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	310	5	1	3	4.1	CCCC(=O)Nc1ccc(N(C)c2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL7807	205144	0	None	74	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	310	5	1	3	4.1	CCCC(=O)Nc1ccc(N(C)c2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
		11824365	107367	0	None	47	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1ccc(Cc2oc3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1021/jm0005252
		CHEMBL317742	107367	0	None	47	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1ccc(Cc2oc3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1021/jm0005252
		1359	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm980684+
		5311198	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm980684+
		CHEMBL274438	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm980684+
		1359	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm800974d
		5311198	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm800974d
		CHEMBL274438	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm800974d
		137640407	156743	0	None	67	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	270	5	1	3	2.5	COc1ccc2cccc(CCC(=O)NC3CC3)c2n1	10.1016/j.ejmech.2016.12.013
		CHEMBL4070527	156743	0	None	67	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	270	5	1	3	2.5	COc1ccc2cccc(CCC(=O)NC3CC3)c2n1	10.1016/j.ejmech.2016.12.013
		11644612	78298	0	None	9	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
		CHEMBL210791	78298	0	None	9	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
		1357	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
		1672	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
		224	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
		896	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
		CHEMBL45	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
		DB01065	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
		1359	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm401343c
		5311198	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm401343c
		CHEMBL274438	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm401343c
		1359	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm048956y
		5311198	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm048956y
		CHEMBL274438	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm048956y
		10704399	21507	0	None	8	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	225	2	1	1	2.6	CC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
		CHEMBL131602	21507	0	None	8	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	225	2	1	1	2.6	CC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
		10616723	98305	0	None	14	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	4	1	3	3.6	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCc2ccccc2-1	10.1021/jm980684+
		CHEMBL274842	98305	0	None	14	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	4	1	3	3.6	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCc2ccccc2-1	10.1021/jm980684+
		44579115	181835	0	None	162	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	348	6	2	3	4.2	CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
		CHEMBL477835	181835	0	None	162	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	348	6	2	3	4.2	CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
		1357	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
		1672	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
		224	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
		896	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
		CHEMBL45	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
		DB01065	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
		12985494	190629	0	None	239	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	7	2	3	4.1	CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
		CHEMBL518113	190629	0	None	239	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	7	2	3	4.1	CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
		16094585	82890	0	None	204	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
		CHEMBL218065	82890	0	None	204	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
		1357	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
		1672	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
		224	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
		896	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
		CHEMBL45	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
		DB01065	2485	139	None	1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
		24954991	63793	0	None	-3	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	259	3	1	4	1.3	CC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3	10.1021/jm200385u
		CHEMBL1802023	63793	0	None	-3	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	259	3	1	4	1.3	CC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3	10.1021/jm200385u
		23642307	158895	1	None	8	3	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
		CHEMBL4095334	158895	1	None	8	3	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
		44429448	87747	0	None	7	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	324	5	2	2	3.0	CCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		CHEMBL233729	87747	0	None	7	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	324	5	2	2	3.0	CCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		9948714	20704	0	None	-2	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	313	5	1	3	3.4	COc1ccc2ccc(OC)c3c2c1CCC3CCNC(C)=O	10.1021/jm000922c
		CHEMBL130898	20704	0	None	-2	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	313	5	1	3	3.4	COc1ccc2ccc(OC)c3c2c1CCC3CCNC(C)=O	10.1021/jm000922c
		9883864	116654	0	None	-7	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	327	6	1	3	3.8	CCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
		CHEMBL337024	116654	0	None	-7	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	327	6	1	3	3.8	CCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
		71508233	87074	0	None	40	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	355	10	1	3	3.9	CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
		CHEMBL2326201	87074	0	None	40	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	355	10	1	3	3.9	CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
		12985491	186980	0	None	91	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	411	6	1	2	5.1	COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		CHEMBL490595	186980	0	None	91	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	411	6	1	2	5.1	COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		10753255	118491	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	251	3	1	1	3.0	O=C(NCC1Cc2cccc3cccc1c23)C1CC1	10.1021/jm000922c
		CHEMBL341439	118491	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	251	3	1	1	3.0	O=C(NCC1Cc2cccc3cccc1c23)C1CC1	10.1021/jm000922c
		10778397	19835	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	4	1	2	3.0	COc1ccc2cccc3c2c1C(CCNC(C)=O)C3	10.1021/jm000922c
		CHEMBL130203	19835	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	4	1	2	3.0	COc1ccc2cccc3c2c1C(CCNC(C)=O)C3	10.1021/jm000922c
		52918077	60753	2	None	2	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		CHEMBL1760945	60753	2	None	2	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		127026427	137684	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
		CHEMBL3758679	137684	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
		1357	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
		1672	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
		224	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
		896	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
		CHEMBL45	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
		DB01065	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
		44579260	187115	0	None	38	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	6	1	4	4.0	COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
		CHEMBL491605	187115	0	None	38	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	6	1	4	4.0	COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
		24750192	3917	13	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	10.1021/jm700957j
		7777	3917	13	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	10.1021/jm700957j
		CHEMBL237236	3917	13	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	10.1021/jm700957j
		11185529	3914	5	None	14	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm040768k
		7772	3914	5	None	14	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm040768k
		CHEMBL189449	3914	5	None	14	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm040768k
		11185529	3914	5	None	14	2	Human	9.2	pKi	=	9.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm048956y
		7772	3914	5	None	14	2	Human	9.2	pKi	=	9.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm048956y
		CHEMBL189449	3914	5	None	14	2	Human	9.2	pKi	=	9.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm048956y
		44429447	87746	0	None	5	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	310	4	2	2	2.6	COc1cc(Br)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
		CHEMBL233728	87746	0	None	5	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	310	4	2	2	2.6	COc1cc(Br)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
		44429443	145345	0	None	4	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	274	6	2	2	2.9	CCCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		CHEMBL391350	145345	0	None	4	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	274	6	2	2	2.9	CCCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		44264871	205030	0	None	26	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	297	5	1	3	4.2	CCCC(=O)Nc1ccc(Oc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL7700	205030	0	None	26	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	297	5	1	3	4.2	CCCC(=O)Nc1ccc(Oc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
		52918080	60764	0	None	13	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	287	4	1	4	2.1	COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3	10.1016/j.bmcl.2011.02.097
		CHEMBL1760957	60764	0	None	13	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	287	4	1	4	2.1	COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3	10.1016/j.bmcl.2011.02.097
		9884156	207876	0	None	77	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	7	1	3	3.9	C=CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
		CHEMBL96548	207876	0	None	77	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	7	1	3	3.9	C=CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
		164946945	190229	1	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
		CHEMBL5174929	190229	1	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
		1357	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
		1672	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
		224	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
		896	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
		CHEMBL45	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
		DB01065	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
		127029516	137634	0	None	6	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3occ(CNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
		CHEMBL3758225	137634	0	None	6	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3occ(CNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
		127025784	137733	0	None	8	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1	10.1016/j.ejmech.2015.12.047
		CHEMBL3759084	137733	0	None	8	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1	10.1016/j.ejmech.2015.12.047
		15453084	86410	0	None	-2	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	255	3	1	2	2.8	COc1ccc2cccc([C@@H]3C[C@H]3NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
		CHEMBL2314251	86410	0	None	-2	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	255	3	1	2	2.8	COc1ccc2cccc([C@@H]3C[C@H]3NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
		1357	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
		1672	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
		224	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
		896	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
		CHEMBL45	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
		DB01065	2485	139	None	1	9	Human	9.2	pKi	=	9.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
		44264904	205621	0	None	57	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	295	5	1	2	4.0	CCCC(=O)Nc1ccc(Cc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL8169	205621	0	None	57	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	295	5	1	2	4.0	CCCC(=O)Nc1ccc(Cc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
		12985492	181831	0	None	177	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	459	6	1	2	5.1	COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		CHEMBL477833	181831	0	None	177	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	459	6	1	2	5.1	COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		11681026	77140	0	None	11	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	302	6	1	3	3.4	CCCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
		CHEMBL207745	77140	0	None	11	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	302	6	1	3	3.4	CCCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
		1357	2485	139	None	1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
		1672	2485	139	None	1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
		224	2485	139	None	1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
		896	2485	139	None	1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
		CHEMBL45	2485	139	None	1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
		DB01065	2485	139	None	1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
		9947753	204900	0	None	83	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	285	6	1	3	4.2	CCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL7599	204900	0	None	83	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	285	6	1	3	4.2	CCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		44264949	204968	0	None	83	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	299	7	1	3	4.6	CCCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL7650	204968	0	None	83	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	299	7	1	3	4.6	CCCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		44272422	167879	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	288	5	2	3	3.1	CCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1	10.1016/j.bmcl.2003.12.052
		CHEMBL431103	167879	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	288	5	2	3	3.1	CCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1	10.1016/j.bmcl.2003.12.052
		59145872	186176	0	None	-2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	257	3	1	3	2.1	CC(=O)NCCC1CCc2ccc3nn(C)cc3c21	10.1021/acs.jmedchem.0c01836
		CHEMBL4872592	186176	0	None	-2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	257	3	1	3	2.1	CC(=O)NCCC1CCc2ccc3nn(C)cc3c21	10.1021/acs.jmedchem.0c01836
		10750842	188682	3	None	30	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	207	5	1	2	1.8	COc1cccc(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
		CHEMBL50398	188682	3	None	30	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	207	5	1	2	1.8	COc1cccc(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
		24750069	150483	0	None	66	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	298	7	1	3	2.8	COc1cccc(N(CCNC(C)=O)Cc2ccccc2)c1	10.1021/jm700957j
		CHEMBL395437	150483	0	None	66	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	298	7	1	3	2.8	COc1cccc(N(CCNC(C)=O)Cc2ccccc2)c1	10.1021/jm700957j
		53238411	62029	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	375	4	1	2	4.9	CC(=O)NCCC1=C(c2ccc(C(C)(C)C)cc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
		CHEMBL1774530	62029	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting	ChEMBL	375	4	1	2	4.9	CC(=O)NCCC1=C(c2ccc(C(C)(C)C)cc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
		10873443	195224	4	None	1	2	Human	9.1	pKi	=	9.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	417	5	1	5	2.4	COc1cc2c(CCNC(C)=O)c(I)n(C)c2cc1[N+](=O)[O-]	10.1021/jm011053+
		CHEMBL55084	195224	4	None	1	2	Human	9.1	pKi	=	9.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	417	5	1	5	2.4	COc1cc2c(CCNC(C)=O)c(I)n(C)c2cc1[N+](=O)[O-]	10.1021/jm011053+
		44264909	205234	0	None	117	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	293	5	1	2	4.8	CCCC(=O)Nc1ccc(Cc2cccc3occc23)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL7875	205234	0	None	117	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	293	5	1	2	4.8	CCCC(=O)Nc1ccc(Cc2cccc3occc23)cc1	10.1016/j.bmcl.2003.11.030
		137641357	157079	0	None	3	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
		CHEMBL4074273	157079	0	None	3	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
		9817636	20675	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	295	4	1	2	3.4	COc1ccc2cccc3c2c1CCC3CNC(=O)C1CC1	10.1021/jm000922c
		CHEMBL130876	20675	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	295	4	1	2	3.4	COc1ccc2cccc3c2c1CCC3CNC(=O)C1CC1	10.1021/jm000922c
		44272443	195487	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	302	6	2	3	3.5	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
		CHEMBL553105	195487	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	302	6	2	3	3.5	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
		139451790	185296	18	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
		CHEMBL4859295	185296	18	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
		127025788	137767	0	None	53	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	300	3	2	3	3.2	CNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
		CHEMBL3759372	137767	0	None	53	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	300	3	2	3	3.2	CNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
		145983929	166421	0	None	6	3	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	4	1	3	2.8	COc1ccc2ccc3c(c2n1)C(CCNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
		CHEMBL4277185	166421	0	None	6	3	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	4	1	3	2.8	COc1ccc2ccc3c(c2n1)C(CCNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
		1348	1845	5	None	100	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10.1021/jm401343c
		44208891	1845	5	None	100	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10.1021/jm401343c
		CHEMBL3260983	1845	5	None	100	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10.1021/jm401343c
		57381112	1416	0	None	-20	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
		7776	1416	0	None	-20	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
		CHEMBL1946221	1416	0	None	-20	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
		57381112	1416	0	None	-20	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
		7776	1416	0	None	-20	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
		CHEMBL1946221	1416	0	None	-20	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
		11536939	77114	0	None	12	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	314	6	1	3	3.5	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1	10.1021/jm0512544
		CHEMBL207625	77114	0	None	12	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	314	6	1	3	3.5	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1	10.1021/jm0512544
		53231366	62401	0	None	66	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	5	1	3	5.0	CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
		CHEMBL1779804	62401	0	None	66	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	5	1	3	5.0	CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
		24750188	149244	0	None	114	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	314	7	1	4	3.0	COc1ccc(N(CCNC(C)=O)c2cccc(OC)c2)cc1	10.1021/jm700957j
		CHEMBL394430	149244	0	None	114	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	314	7	1	4	3.0	COc1ccc(N(CCNC(C)=O)c2cccc(OC)c2)cc1	10.1021/jm700957j
		44272440	67526	0	None	-2	2	Human	9.1	pKi	=	9.1	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	260	4	2	3	2.5	CCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1	10.1016/j.bmcl.2003.12.052
		CHEMBL18960	67526	0	None	-2	2	Human	9.1	pKi	=	9.1	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	260	4	2	3	2.5	CCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1	10.1016/j.bmcl.2003.12.052
		11426853	166368	0	None	3	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	309	3	1	3	2.7	COc1ccc2c(c1)C(CNC(C)=O)Cc1ccccc1C2=O	10.1021/jm040768k
		CHEMBL427516	166368	0	None	3	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	309	3	1	3	2.7	COc1ccc2c(c1)C(CNC(C)=O)Cc1ccccc1C2=O	10.1021/jm040768k
		10044270	189544	0	None	891	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	6	1	2	4.8	COc1ccc2c(c1)[C@@H](CCNC(=O)C1CCC1)C[C@@H](c1ccccc1)C2	10.1021/jm800974d
		CHEMBL514280	189544	0	None	891	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	6	1	2	4.8	COc1ccc2c(c1)[C@@H](CCNC(=O)C1CCC1)C[C@@H](c1ccccc1)C2	10.1021/jm800974d
		139451757	184831	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
		CHEMBL4852096	184831	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
		139451795	185329	0	None	-2	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
		CHEMBL4859677	185329	0	None	-2	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
		24954992	63798	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	313	3	1	4	2.0	CC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3	10.1021/jm200385u
		CHEMBL1802029	63798	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	313	3	1	4	2.0	CC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3	10.1021/jm200385u
		44358274	28953	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	261	2	2	3	1.1	CNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		CHEMBL138012	28953	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	261	2	2	3	1.1	CNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		44579163	182129	0	None	53	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	362	6	1	3	4.3	COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		CHEMBL478217	182129	0	None	53	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	362	6	1	3	4.3	COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		10712600	4358	0	None	48	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	346	5	1	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1	10.1021/jm980684+
		CHEMBL10110	4358	0	None	48	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	346	5	1	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1	10.1021/jm980684+
		1357	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		1672	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		224	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		896	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		CHEMBL45	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		DB01065	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		12985493	187092	0	None	213	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	7	1	3	4.3	COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
		CHEMBL491403	187092	0	None	213	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	7	1	3	4.3	COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
		25025104	186315	0	None	-5	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	4	1	3	2.6	CCC(=O)NCCC1CCc2ccn3nc(C)cc3c21	10.1021/acs.jmedchem.0c01836
		CHEMBL4874630	186315	0	None	-5	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	4	1	3	2.6	CCC(=O)NCCC1CCc2ccn3nc(C)cc3c21	10.1021/acs.jmedchem.0c01836
		1357	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
		1672	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
		224	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
		896	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
		CHEMBL45	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
		DB01065	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
		1357	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
		1672	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
		224	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
		896	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
		CHEMBL45	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
		DB01065	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
		1357	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
		1672	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
		224	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
		896	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
		CHEMBL45	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
		DB01065	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
		1357	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
		1672	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
		224	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
		896	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
		CHEMBL45	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
		DB01065	2485	139	None	1	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
		10061064	102968	0	None	7	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	258	5	1	3	2.3	CCC(=O)NCCc1ccnc2ccc(OC)cc12	10.1016/S0960-894X(97)00392-2
		CHEMBL306468	102968	0	None	7	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	258	5	1	3	2.3	CCC(=O)NCCc1ccnc2ccc(OC)cc12	10.1016/S0960-894X(97)00392-2
		23658144	158179	1	None	6	3	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
		CHEMBL4087633	158179	1	None	6	3	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
		44358184	116540	0	None	1	2	Human	9.0	pKi	=	9	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	246	2	1	3	1.3	CC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		CHEMBL336268	116540	0	None	1	2	Human	9.0	pKi	=	9	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	246	2	1	3	1.3	CC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		10015475	16763	0	None	3	2	Human	9.0	pKi	=	9	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	2.8	CCC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL124362	16763	0	None	3	2	Human	9.0	pKi	=	9	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	2.8	CCC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
		9970584	16771	0	None	8	2	Human	9.0	pKi	=	9	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	7	1	3	3.2	CCCC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL124422	16771	0	None	8	2	Human	9.0	pKi	=	9	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	7	1	3	3.2	CCCC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
		44272444	67946	0	None	3	2	Human	9.0	pKi	=	9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	303	6	3	3	3.0	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)NCC)c2O1	10.1016/j.bmcl.2003.12.052
		CHEMBL19109	67946	0	None	3	2	Human	9.0	pKi	=	9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	303	6	3	3	3.0	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)NCC)c2O1	10.1016/j.bmcl.2003.12.052
		137636079	156227	0	None	19	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	232	3	1	2	1.8	CCN1CC(CNC(C)=O)Cc2ccccc21	10.1021/acs.jmedchem.8b00359
		CHEMBL4064626	156227	0	None	19	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	232	3	1	2	1.8	CCN1CC(CNC(C)=O)Cc2ccccc21	10.1021/acs.jmedchem.8b00359
		137645887	157940	0	None	58	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	294	4	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
		CHEMBL4084568	157940	0	None	58	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	294	4	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
		86273226	121318	0	None	5	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	256	5	2	2	1.9	C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
		CHEMBL3580908	121318	0	None	5	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	256	5	2	2	1.9	C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
		137660726	159332	0	None	15	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	322	6	1	5	1.6	CCS(=O)(=O)NC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
		CHEMBL4100108	159332	0	None	15	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	322	6	1	5	1.6	CCS(=O)(=O)NC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
		11550834	139544	0	None	4	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	274	5	1	3	2.8	CCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
		CHEMBL379616	139544	0	None	4	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	274	5	1	3	2.8	CCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
		44429442	150223	0	None	1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	260	5	2	2	2.6	CCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		CHEMBL395221	150223	0	None	1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	260	5	2	2	2.6	CCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		25210130	69	0	None	91	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
		7782	69	0	None	91	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
		CHEMBL514415	69	0	None	91	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
		57781248	184563	0	None	1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	4	2	4	1.9	CC(=O)NCCC1CCc2ccc3nc(CO)oc3c21	10.1021/acs.jmedchem.0c01836
		CHEMBL4848381	184563	0	None	1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	4	2	4	1.9	CC(=O)NCCC1CCc2ccc3nc(CO)oc3c21	10.1021/acs.jmedchem.0c01836
		11507534	166133	0	None	5	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	288	5	1	3	3.0	CCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
		CHEMBL426127	166133	0	None	5	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	288	5	1	3	3.0	CCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
		11784134	106949	0	None	67	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	391	6	1	3	4.7	COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		CHEMBL314947	106949	0	None	67	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	391	6	1	3	4.7	COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		25210130	69	0	None	91	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
		7782	69	0	None	91	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
		CHEMBL514415	69	0	None	91	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
		44272431	98857	0	None	4	2	Human	8.9	pKi	=	8.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	274	4	2	3	2.7	CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
		CHEMBL278922	98857	0	None	4	2	Human	8.9	pKi	=	8.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	274	4	2	3	2.7	CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
		19703015	137898	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	234	4	1	4	1.5	COc1ccc2occ(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		CHEMBL3763281	137898	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	234	4	1	4	1.5	COc1ccc2occ(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		10754723	169198	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	273	5	2	3	2.6	CCC(=O)NCCc1c(O)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
		CHEMBL440692	169198	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	273	5	2	3	2.6	CCC(=O)NCCc1c(O)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
		44317845	205506	0	None	-3	2	Human	8.9	pKi	=	8.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	301	7	1	3	3.3	CCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
		CHEMBL80736	205506	0	None	-3	2	Human	8.9	pKi	=	8.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	301	7	1	3	3.3	CCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
		11587169	77317	0	None	8	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	274	4	1	3	2.6	COc1ccc2c(c1)c(C(C)(C)CNC(C)=O)cn2C	10.1021/jm0512544
		CHEMBL208307	77317	0	None	8	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	274	4	1	3	2.6	COc1ccc2c(c1)c(C(C)(C)CNC(C)=O)cn2C	10.1021/jm0512544
		127039212	138027	0	None	154	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	5	1	4	4.3	COc1ccc2oc(-c3cccc4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		CHEMBL3764879	138027	0	None	154	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	5	1	4	4.3	COc1ccc2oc(-c3cccc4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		10495702	205235	0	None	3	2	Human	8.9	pKi	=	8.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	317	8	2	4	2.3	CCC(=O)NCCc1c(OCCO)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
		CHEMBL78751	205235	0	None	3	2	Human	8.9	pKi	=	8.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	317	8	2	4	2.3	CCC(=O)NCCc1c(OCCO)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
		44429449	87363	0	None	7	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	324	4	1	3	2.6	COc1cc(Br)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
		CHEMBL233309	87363	0	None	7	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	324	4	1	3	2.6	COc1cc(Br)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
		44429446	146732	0	None	14	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	288	6	1	3	3.0	CCCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		CHEMBL392422	146732	0	None	14	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	288	6	1	3	3.0	CCCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		137641357	157079	0	None	3	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
		CHEMBL4074273	157079	0	None	3	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
		10399579	203983	0	None	4	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	244	4	1	3	1.9	COc1ccc2nccc(CCNC(C)=O)c2c1	10.1016/S0960-894X(97)00392-2
		CHEMBL69521	203983	0	None	4	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	244	4	1	3	1.9	COc1ccc2nccc(CCNC(C)=O)c2c1	10.1016/S0960-894X(97)00392-2
		139451769	186142	0	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC	10.1021/acs.jmedchem.0c00627
		CHEMBL4872217	186142	0	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC	10.1021/acs.jmedchem.0c00627
		59145922	186272	0	None	-7	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	257	3	1	3	2.2	CC(=O)NCCC1CCc2ccn3nc(C)cc3c21	10.1021/acs.jmedchem.0c01836
		CHEMBL4874010	186272	0	None	-7	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	257	3	1	3	2.2	CC(=O)NCCC1CCc2ccn3nc(C)cc3c21	10.1021/acs.jmedchem.0c01836
		44426096	85736	0	None	4	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	211	2	1	1	2.9	CC(=O)N/C=C/c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
		CHEMBL229015	85736	0	None	4	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	211	2	1	1	2.9	CC(=O)N/C=C/c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
		10737372	4632	0	None	37	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	5	1	3	4.3	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCCc1ccccc1-2	10.1021/jm980684+
		CHEMBL10293	4632	0	None	37	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	5	1	3	4.3	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCCc1ccccc1-2	10.1021/jm980684+
		1358	124	41	None	870	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm401343c
		3976006	124	41	None	870	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm401343c
		CHEMBL285718	124	41	None	870	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm401343c
		9819843	208138	0	None	20	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	8	1	3	4.3	COc1ccc2oc(CCCc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		CHEMBL98074	208138	0	None	20	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	8	1	3	4.3	COc1ccc2oc(CCCc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		16094594	83246	0	None	165	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C\CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
		CHEMBL218709	83246	0	None	165	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C\CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
		44429444	146731	0	None	5	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.2	COc1cc(C)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
		CHEMBL392421	146731	0	None	5	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.2	COc1cc(C)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
		10640828	21482	0	None	-2	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	339	6	1	3	3.8	COc1ccc2ccc(OC)c3c2c1CCC3CCNC(=O)C1CC1	10.1021/jm000922c
		CHEMBL131575	21482	0	None	-2	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	339	6	1	3	3.8	COc1ccc2ccc(OC)c3c2c1CCC3CCNC(=O)C1CC1	10.1021/jm000922c
		46885284	8105	0	None	114	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	251	7	1	3	2.2	CCOc1ccc(OC)cc1CCCNC(C)=O	10.1016/j.bmcl.2010.02.084
		CHEMBL1091561	8105	0	None	114	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	251	7	1	3	2.2	CCOc1ccc(OC)cc1CCCNC(C)=O	10.1016/j.bmcl.2010.02.084
		139451766	184447	0	None	8	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
		CHEMBL4846505	184447	0	None	8	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
		10831675	21780	0	None	6	2	Human	8.8	pKi	=	8.8	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells	ChEMBL	349	7	1	4	3.1	CCC(=O)NCCc1c(OC(=O)CCl)ccc2ccc(OC)cc12	10.1021/jm970437q
		CHEMBL131919	21780	0	None	6	2	Human	8.8	pKi	=	8.8	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells	ChEMBL	349	7	1	4	3.1	CCC(=O)NCCc1c(OC(=O)CCl)ccc2ccc(OC)cc12	10.1021/jm970437q
		46884552	8127	0	None	1122	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	314	8	1	4	2.7	COc1ccc(OCc2ccccn2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
		CHEMBL1091716	8127	0	None	1122	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	314	8	1	4	2.7	COc1ccc(OCc2ccccn2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
		10567865	4178	0	None	38	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	322	6	1	3	3.7	CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
		CHEMBL100104	4178	0	None	38	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	322	6	1	3	3.7	CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
		46865422	87071	0	None	575	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1039/C1MD00149C
		CHEMBL2326199	87071	0	None	575	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1039/C1MD00149C
		12324	3911	0	None	-2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	10.1021/acs.jmedchem.8b00893
		145966622	3911	0	None	-2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	10.1021/acs.jmedchem.8b00893
		CHEMBL4210086	3911	0	None	-2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	10.1021/acs.jmedchem.8b00893
		11068422	207844	0	None	7	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	361	6	1	4	4.7	COc1ccc2oc(-c3ccccc3)c(CCNC(=O)c3ccco3)c2c1	10.1021/jm0005252
		CHEMBL96420	207844	0	None	7	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	361	6	1	4	4.7	COc1ccc2oc(-c3ccccc3)c(CCNC(=O)c3ccco3)c2c1	10.1021/jm0005252
		127026424	137692	0	None	5	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3oc(CCNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
		CHEMBL3758720	137692	0	None	5	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3oc(CCNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
		46865422	87071	0	None	575	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.ejmech.2016.01.008
		CHEMBL2326199	87071	0	None	575	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.ejmech.2016.01.008
		11776674	116649	1	None	1	2	Human	8.8	pKi	=	8.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B	ChEMBL	246	4	1	3	1.9	COc1ccc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm020982d
		CHEMBL33700	116649	1	None	1	2	Human	8.8	pKi	=	8.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B	ChEMBL	246	4	1	3	1.9	COc1ccc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm020982d
		44429441	86726	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	246	4	2	2	2.2	COc1cc(C)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
		CHEMBL231872	86726	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	246	4	2	2	2.2	COc1cc(C)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
		9914839	98156	0	None	-34	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	526	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
		CHEMBL273787	98156	0	None	-34	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	526	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
		10424693	109643	1	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	297	4	1	2	3.1	COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1	10.1039/C5MD00190K
		CHEMBL322339	109643	1	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	297	4	1	2	3.1	COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1	10.1039/C5MD00190K
		127038129	136872	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	311	5	1	2	3.3	COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1	10.1039/C5MD00190K
		CHEMBL3742090	136872	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	311	5	1	2	3.3	COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1	10.1039/C5MD00190K
		22718564	16780	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	5	1	3	2.3	CCC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
		CHEMBL124476	16780	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	5	1	3	2.3	CCC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
		44264706	204430	1	None	33	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	270	5	2	3	3.8	CCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL7215	204430	1	None	33	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	270	5	2	3	3.8	CCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		46888521	8644	0	None	-26	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	499	12	1	5	5.6	COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
		CHEMBL1095196	8644	0	None	-26	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	499	12	1	5	5.6	COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
		10611901	23576	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	267	5	1	1	3.8	CCCC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
		CHEMBL133426	23576	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	267	5	1	1	3.8	CCCC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
		10729569	116556	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	253	4	1	1	3.4	CCC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
		CHEMBL336333	116556	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	253	4	1	1	3.4	CCC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
		12985489	190236	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	349	6	2	3	3.7	COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		CHEMBL517502	190236	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	349	6	2	3	3.7	COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		44272305	67323	0	None	-14	2	Human	8.7	pKi	=	8.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	392	9	2	3	5.1	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2	10.1016/j.bmcl.2003.12.052
		CHEMBL18845	67323	0	None	-14	2	Human	8.7	pKi	=	8.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	392	9	2	3	5.1	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2	10.1016/j.bmcl.2003.12.052
		24750193	88553	1	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	236	6	1	3	1.7	COc1cccc(N(C)CCCNC(C)=O)c1	10.1021/jm700957j
		CHEMBL235329	88553	1	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	236	6	1	3	1.7	COc1cccc(N(C)CCCNC(C)=O)c1	10.1021/jm700957j
		168274836	190147	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
		CHEMBL5173623	190147	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
		22718610	16888	0	None	1	2	Human	8.0	pKi	=	8	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	308	6	1	3	4.0	CCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL125033	16888	0	None	1	2	Human	8.0	pKi	=	8	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	308	6	1	3	4.0	CCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		9797715	204940	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	333	6	1	4	3.3	CCCC(=O)Nc1ccc(S(=O)(=O)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL7637	204940	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	333	6	1	4	3.3	CCCC(=O)Nc1ccc(S(=O)(=O)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL3109563	211091	0	None	3	2	Human	8.0	pKi	=	8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells after 120 mins	ChEMBL		None	None	None		COc1ccc2c(c1)c(CCNC(C)=O)c1n2[B-](F)(F)[N+]2=C(C)C=C(C)C2=C1	10.1021/ml4004155
		10545399	205512	0	None	4	2	Human	8.0	pKi	=	8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	344	9	1	4	2.9	CCC(=O)NCCc1c(OCCN(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
		CHEMBL80792	205512	0	None	4	2	Human	8.0	pKi	=	8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	344	9	1	4	2.9	CCC(=O)NCCc1c(OCCN(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
		44394435	66927	0	None	-3	2	Human	8.0	pKi	=	8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	361	8	1	2	5.2	CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		CHEMBL186586	66927	0	None	-3	2	Human	8.0	pKi	=	8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	361	8	1	2	5.2	CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		44394415	124407	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	389	10	1	2	6.0	CCCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		CHEMBL363947	124407	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	389	10	1	2	6.0	CCCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		122162	2387	75	None	18	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm401343c
		1363	2387	75	None	18	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm401343c
		CHEMBL286615	2387	75	None	18	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm401343c
		11066802	100087	0	None	21	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	308	5	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
		CHEMBL287343	100087	0	None	21	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	308	5	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
		11098363	169116	1	None	14	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	293	5	1	2	3.7	CC(=O)NCCc1c(Cc2ccccc2)oc2ccccc12	10.1021/jm0005252
		CHEMBL440144	169116	1	None	14	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	293	5	1	2	3.7	CC(=O)NCCc1c(Cc2ccccc2)oc2ccccc12	10.1021/jm0005252
		53231464	62406	0	None	21	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	375	6	1	3	5.2	C=CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
		CHEMBL1779809	62406	0	None	21	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	375	6	1	3	5.2	C=CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
		44358275	168453	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	287	3	2	3	1.7	O=C(NC1CC1)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		CHEMBL435023	168453	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	287	3	2	3	1.7	O=C(NC1CC1)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		9937825	8868	0	None	-12	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	564	17	2	4	6.7	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12	10.1016/j.bmc.2010.04.008
		CHEMBL1097315	8868	0	None	-12	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	564	17	2	4	6.7	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12	10.1016/j.bmc.2010.04.008
		56661512	64447	0	None	-23	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	470	15	2	6	3.1	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
		CHEMBL1813319	64447	0	None	-23	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	470	15	2	6	3.1	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
		11681201	141076	0	None	2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	314	5	1	3	3.5	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1	10.1021/jm0512544
		CHEMBL382555	141076	0	None	2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	314	5	1	3	3.5	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1	10.1021/jm0512544
		46884550	8184	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	409	8	1	3	4.2	COc1ccc(OCc2ccc(Br)cc2F)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
		CHEMBL1091997	8184	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	409	8	1	3	4.2	COc1ccc(OCc2ccc(Br)cc2F)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
		44412079	166257	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	286	4	2	3	2.8	CCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
		CHEMBL426861	166257	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	286	4	2	3	2.8	CCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
		46884599	8419	0	None	13	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1cccc(COc2ccc(CCCNC(C)=O)cc2OC)c1	10.1016/j.bmcl.2010.02.084
		CHEMBL1093457	8419	0	None	13	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1cccc(COc2ccc(CCCNC(C)=O)cc2OC)c1	10.1016/j.bmcl.2010.02.084
		9795837	161799	4	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	285	6	1	3	4.2	CCCC(=O)Nc1ccc(Oc2ccccc2OC)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL414212	161799	4	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	285	6	1	3	4.2	CCCC(=O)Nc1ccc(Oc2ccccc2OC)cc1	10.1016/j.bmcl.2003.11.030
		162661094	181443	3	None	10	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
		CHEMBL4764211	181443	3	None	10	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
		49865203	15849	0	None	-2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(O[C@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223049	15849	0	None	-2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(O[C@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
		54583162	60761	0	None	7	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	276	6	2	5	0.9	CNCc1cn(CCNC(C)=O)c2nc(OC)ccc12	10.1016/j.bmcl.2011.02.097
		CHEMBL1760954	60761	0	None	7	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	276	6	2	5	0.9	CNCc1cn(CCNC(C)=O)c2nc(OC)ccc12	10.1016/j.bmcl.2011.02.097
		11208578	125889	0	None	1	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	292	2	1	2	3.0	CC(=O)NCC(=O)N1c2ccccc2C=Cc2ccccc21	10.1021/jm040768k
		CHEMBL364845	125889	0	None	1	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	292	2	1	2	3.0	CC(=O)NCC(=O)N1c2ccccc2C=Cc2ccccc21	10.1021/jm040768k
		139451776	185011	0	None	-5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
		CHEMBL4854836	185011	0	None	-5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
		127025781	137824	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
		CHEMBL3759859	137824	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
		18007985	8716	0	None	-10	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	538	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12	10.1016/j.bmc.2010.04.008
		CHEMBL1095832	8716	0	None	-10	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	538	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12	10.1016/j.bmc.2010.04.008
		16094582	83314	5	None	44	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.3	CC(=O)NCC=C(c1ccccc1)c1ccccc1	10.1021/jm060850a
		CHEMBL219076	83314	5	None	44	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.3	CC(=O)NCC=C(c1ccccc1)c1ccccc1	10.1021/jm060850a
		16743295	93189	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	284	6	1	2	3.4	CCCC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
		CHEMBL244472	93189	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	284	6	1	2	3.4	CCCC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
		9860588	19946	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	COc1ccc2cccc3c2c1CCC3CCNC(C)=O	10.1021/jm000922c
		CHEMBL130286	19946	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	COc1ccc2cccc3c2c1CCC3CCNC(C)=O	10.1021/jm000922c
		46888492	8843	0	None	-18	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	564	14	2	5	6.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12	10.1016/j.bmc.2010.04.008
		CHEMBL1096991	8843	0	None	-18	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	564	14	2	5	6.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12	10.1016/j.bmc.2010.04.008
		44264964	205266	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	281	5	1	3	3.4	C#CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL7898	205266	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	281	5	1	3	3.4	C#CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		130400672	156996	0	None	3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	204	2	2	2	1.4	CC(=O)NCC1CNc2ccccc2C1	10.1021/acs.jmedchem.8b00359
		CHEMBL4073210	156996	0	None	3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	204	2	2	2	1.4	CC(=O)NCC1CNc2ccccc2C1	10.1021/acs.jmedchem.8b00359
		162673578	183118	0	None	5	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	272	5	2	5	2.4	CNc1nnc(CCc2c[nH]c3ccc(OC)cc23)o1	10.1016/j.ejmech.2020.112090
		CHEMBL4794879	183118	0	None	5	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	272	5	2	5	2.4	CNc1nnc(CCc2c[nH]c3ccc(OC)cc23)o1	10.1016/j.ejmech.2020.112090
		1362	3437	22	None	-39	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
		9870523	3437	22	None	-39	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
		CHEMBL429392	3437	22	None	-39	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
		1362	3437	22	None	-39	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to MT2 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
		9870523	3437	22	None	-39	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to MT2 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
		CHEMBL429392	3437	22	None	-39	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to MT2 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
		1362	3437	22	None	-39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 mins	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
		9870523	3437	22	None	-39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 mins	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
		CHEMBL429392	3437	22	None	-39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 mins	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
		10544425	208337	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	330	4	1	2	4.1	O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CCC1	10.1021/jm980684+
		CHEMBL9934	208337	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	330	4	1	2	4.1	O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CCC1	10.1021/jm980684+
		44349270	113092	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	286	6	1	3	3.4	CC(C)c1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
		CHEMBL331317	113092	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	286	6	1	3	3.4	CC(C)c1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
		10893437	208449	0	None	6	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	348	6	1	3	4.1	COc1cccc2c1cc(CCNC(=O)C1CCC1)n2-c1ccccc1	10.1021/jm001125h
		CHEMBL99987	208449	0	None	6	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	348	6	1	3	4.1	COc1cccc2c1cc(CCNC(=O)C1CCC1)n2-c1ccccc1	10.1021/jm001125h
		12436515	15832	2	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)NCC(C)Oc1ccccc1	10.1016/j.bmc.2010.06.100
		CHEMBL1222985	15832	2	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)NCC(C)Oc1ccccc1	10.1016/j.bmc.2010.06.100
		86079062	180732	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2ncnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
		CHEMBL4755860	180732	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2ncnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
		10666373	98321	0	None	4	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	5	1	3	4.3	CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1	10.1021/jm980684+
		CHEMBL274995	98321	0	None	4	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	5	1	3	4.3	CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1	10.1021/jm980684+
		19703063	28915	1	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.bmcl.2011.02.097
		CHEMBL137969	28915	1	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.bmcl.2011.02.097
		19703063	28915	1	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.ejmech.2016.01.008
		CHEMBL137969	28915	1	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.ejmech.2016.01.008
		25210135	174924	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	378	6	3	4	3.0	COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		CHEMBL456505	174924	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	378	6	3	4	3.0	COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		25210135	174924	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	378	6	3	4	3.0	COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		CHEMBL456505	174924	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	378	6	3	4	3.0	COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		44349171	16655	1	None	6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	275	6	2	3	2.6	CCNC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL124217	16655	1	None	6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	275	6	2	3	2.6	CCNC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
		10738183	4377	0	None	41	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	374	5	1	3	4.3	COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
		CHEMBL10124	4377	0	None	41	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	374	5	1	3	4.3	COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
		10591657	4676	0	None	14	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	5	1	2	4.1	CCCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
		CHEMBL10328	4676	0	None	14	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	5	1	2	4.1	CCCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
		162674428	183280	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	273	4	2	4	2.2	COc1ccc2[nH]cc(CC(C)c3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
		CHEMBL4796759	183280	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	273	4	2	4	2.2	COc1ccc2[nH]cc(CC(C)c3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
		44436051	151363	6	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	209	5	1	3	1.2	COc1cccc(OCCNC(C)=O)c1	10.1021/jm700957j
		CHEMBL396132	151363	6	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	209	5	1	3	1.2	COc1cccc(OCCNC(C)=O)c1	10.1021/jm700957j
		44272424	69075	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	289	4	3	3	2.5	CNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
		CHEMBL19237	69075	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	289	4	3	3	2.5	CNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
		46884598	8190	0	None	20	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	223	5	2	3	1.5	COc1cc(CCCNC(C)=O)ccc1O	10.1016/j.bmcl.2010.02.084
		CHEMBL1092047	8190	0	None	20	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	223	5	2	3	1.5	COc1cc(CCCNC(C)=O)ccc1O	10.1016/j.bmcl.2010.02.084
		9930390	207880	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	391	6	1	3	5.0	COc1ccc2oc(Cc3c(Cl)cccc3Cl)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		CHEMBL96562	207880	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	391	6	1	3	5.0	COc1ccc2oc(Cc3c(Cl)cccc3Cl)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		10991315	208295	0	None	23	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	336	7	1	3	4.1	CCC(=O)NCCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
		CHEMBL99001	208295	0	None	23	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	336	7	1	3	4.1	CCC(=O)NCCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
		49865268	15877	0	None	-13	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(OC(C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223128	15877	0	None	-13	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(OC(C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
		44358088	26781	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	246	2	1	3	1.3	CC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		CHEMBL136273	26781	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	246	2	1	3	1.3	CC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		46884555	8342	0	None	16	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.7	CCC(=O)NCCCc1ccc(OCc2ccccc2)c(OC)c1	10.1016/j.bmcl.2010.02.084
		CHEMBL1092911	8342	0	None	16	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.7	CCC(=O)NCCCc1ccc(OCc2ccccc2)c(OC)c1	10.1016/j.bmcl.2010.02.084
		9903953	205037	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	285	5	1	3	4.1	COc1cccc(Oc2ccc(NC(=O)C(C)C)cc2)c1	10.1016/j.bmcl.2003.11.030
		CHEMBL7703	205037	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	285	5	1	3	4.1	COc1cccc(Oc2ccc(NC(=O)C(C)C)cc2)c1	10.1016/j.bmcl.2003.11.030
		10705590	208207	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	246	4	1	3	1.9	COc1ccc2cc(CCNC(C)=O)n(C)c2c1	10.1021/jm001125h
		CHEMBL98484	208207	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	246	4	1	3	1.9	COc1ccc2cc(CCNC(C)=O)n(C)c2c1	10.1021/jm001125h
		49865377	15934	0	None	-1	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC[C@@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223280	15934	0	None	-1	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC[C@@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
		11403195	123679	1	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	278	3	1	2	3.4	CC(=O)NCCN1c2ccccc2C=Cc2ccccc21	10.1021/jm040768k
		CHEMBL362133	123679	1	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	278	3	1	2	3.4	CC(=O)NCCN1c2ccccc2C=Cc2ccccc21	10.1021/jm040768k
		49865147	15830	2	None	3	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1ccc(OC(C)CNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
		CHEMBL1222983	15830	2	None	3	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1ccc(OC(C)CNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
		44412078	139517	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	272	3	2	3	2.4	CC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
		CHEMBL379504	139517	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	272	3	2	3	2.4	CC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
		18522208	127286	0	None	-6	2	Human	6.9	pKi	=	6.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	349	9	1	2	5.1	CC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		CHEMBL365852	127286	0	None	-6	2	Human	6.9	pKi	=	6.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	349	9	1	2	5.1	CC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		145974583	164490	0	None	-4	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	279	9	2	4	1.4	CC(=O)NCCN(C)c1cccc(OCCCCN)c1	10.1021/acs.jmedchem.8b00893
		CHEMBL4214348	164490	0	None	-4	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	279	9	2	4	1.4	CC(=O)NCCN(C)c1cccc(OCCCCN)c1	10.1021/acs.jmedchem.8b00893
		18702059	204997	4	None	7	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	283	5	1	3	3.8	COc1cccc(Oc2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
		CHEMBL7673	204997	4	None	7	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	283	5	1	3	3.8	COc1cccc(Oc2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
		16094583	166140	3	None	69	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	291	5	1	1	4.0	O=C(NCC=C(c1ccccc1)c1ccccc1)C1CCC1	10.1021/jm060850a
		CHEMBL426168	166140	3	None	69	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	291	5	1	1	4.0	O=C(NCC=C(c1ccccc1)c1ccccc1)C1CCC1	10.1021/jm060850a
		10542922	116592	0	None	-6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	309	5	1	2	3.8	COc1ccc2cccc3c2c1CCC3CCNC(=O)C1CC1	10.1021/jm000922c
		CHEMBL336633	116592	0	None	-6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	309	5	1	2	3.8	COc1ccc2cccc3c2c1CCC3CCNC(=O)C1CC1	10.1021/jm000922c
		127026426	137800	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
		CHEMBL3759606	137800	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
		46885286	8168	0	None	218	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.4	COc1ccc(OCCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
		CHEMBL1091895	8168	0	None	218	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.4	COc1ccc(OCCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
		9850873	8867	0	None	-13	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	564	15	2	4	6.4	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1	10.1016/j.bmc.2010.04.008
		CHEMBL1097314	8867	0	None	-13	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	564	15	2	4	6.4	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1	10.1016/j.bmc.2010.04.008
		44359437	29900	0	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1039/C4MD00149D
		CHEMBL138807	29900	0	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1039/C4MD00149D
		168274836	190147	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
		CHEMBL5173623	190147	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
		9870683	8889	0	None	-9	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	502	13	2	5	5.2	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
		CHEMBL1097496	8889	0	None	-9	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	502	13	2	5	5.2	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
		9860638	205754	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	285	6	1	3	4.2	CCCC(=O)Nc1ccccc1Oc1cccc(OC)c1	10.1016/j.bmcl.2003.11.030
		CHEMBL8278	205754	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	285	6	1	3	4.2	CCCC(=O)Nc1ccccc1Oc1cccc(OC)c1	10.1016/j.bmcl.2003.11.030
		49865376	15933	2	None	9	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SCC(C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223279	15933	2	None	9	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SCC(C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
		10447987	116969	2	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B	ChEMBL	308	5	1	3	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2-c1ccccc1	10.1021/jm020982d
		CHEMBL33869	116969	2	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B	ChEMBL	308	5	1	3	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2-c1ccccc1	10.1021/jm020982d
		162663385	181998	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
		CHEMBL4780509	181998	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
		11573203	141078	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	312	5	1	3	3.1	COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCC1)cn2C	10.1021/jm0512544
		CHEMBL382579	141078	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	312	5	1	3	3.1	COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCC1)cn2C	10.1021/jm0512544
		10361427	112871	0	None	-18	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	364	10	1	3	4.9	CCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL330969	112871	0	None	-18	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	364	10	1	3	4.9	CCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		25209860	188983	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.8	COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		CHEMBL508552	188983	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.8	COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		44394532	67246	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	376	7	1	3	4.7	CC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
		CHEMBL188016	67246	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	376	7	1	3	4.7	CC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
		25209860	188983	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.8	COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		CHEMBL508552	188983	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.8	COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		44424017	85323	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	592	14	4	8	3.4	COc1ccc2[nH]c(C(=O)OCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
		CHEMBL226112	85323	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	592	14	4	8	3.4	COc1ccc2[nH]c(C(=O)OCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
		127041170	136689	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	584	15	2	4	6.1	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
		CHEMBL3740377	136689	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	584	15	2	4	6.1	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
		25210131	175315	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12	10.1021/jm800974d
		CHEMBL457352	175315	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12	10.1021/jm800974d
		25210131	175315	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12	10.1021/jm800974d
		CHEMBL457352	175315	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12	10.1021/jm800974d
		25210133	189561	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.7	COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		CHEMBL514427	189561	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.7	COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		11058163	208214	0	None	22	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	386	5	1	3	4.1	COc1cccc2c1c(Br)c(CNC(C)=O)n2Cc1ccccc1	10.1021/jm001125h
		CHEMBL98520	208214	0	None	22	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	386	5	1	3	4.1	COc1cccc2c1c(Br)c(CNC(C)=O)n2Cc1ccccc1	10.1021/jm001125h
		5151463	83333	12	None	29	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	253	5	1	1	3.3	CC(=O)NCCC(c1ccccc1)c1ccccc1	10.1021/jm060850a
		CHEMBL219177	83333	12	None	29	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	253	5	1	1	3.3	CC(=O)NCCC(c1ccccc1)c1ccccc1	10.1021/jm060850a
		10903463	208364	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	324	5	2	2	3.0	CCC(=O)NCCc1[nH]c2cccc(OC)c2c1Br	10.1021/jm001125h
		CHEMBL99502	208364	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	324	5	2	2	3.0	CCC(=O)NCCc1[nH]c2cccc(OC)c2c1Br	10.1021/jm001125h
		44412063	77588	0	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	298	4	2	3	2.8	Cn1cc(C2(CNC(=O)C3CC3)CCC2)c2cc(O)ccc21	10.1021/jm0512544
		CHEMBL208802	77588	0	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	298	4	2	3	2.8	Cn1cc(C2(CNC(=O)C3CC3)CCC2)c2cc(O)ccc21	10.1021/jm0512544
		10609620	208309	1	None	5	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2cc(CCNC(C)=O)[nH]c2c1	10.1021/jm001125h
		CHEMBL99091	208309	1	None	5	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2cc(CCNC(C)=O)[nH]c2c1	10.1021/jm001125h
		16094578	83272	1	None	8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.4	CC(=O)NC/C(=C\c1ccccc1)c1ccccc1	10.1021/jm060850a
		CHEMBL218808	83272	1	None	8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.4	CC(=O)NC/C(=C\c1ccccc1)c1ccccc1	10.1021/jm060850a
		25210132	170877	0	None	9	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1021/jm800974d
		CHEMBL445427	170877	0	None	9	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1021/jm800974d
		1362	3437	22	None	-39	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
		9870523	3437	22	None	-39	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
		CHEMBL429392	3437	22	None	-39	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
		22718585	16506	0	None	9	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	6	1	3	3.4	CCC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL123634	16506	0	None	9	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	6	1	3	3.4	CCC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
		44264950	205046	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	299	6	1	3	4.5	COc1cccc(Oc2ccc(NC(=O)CC(C)C)cc2)c1	10.1016/j.bmcl.2003.11.030
		CHEMBL7708	205046	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	299	6	1	3	4.5	COc1cccc(Oc2ccc(NC(=O)CC(C)C)cc2)c1	10.1016/j.bmcl.2003.11.030
		137653199	158623	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	218	2	1	2	1.4	CC(=O)NCC1Cc2ccccc2N(C)C1	10.1021/acs.jmedchem.8b00359
		CHEMBL4092308	158623	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	218	2	1	2	1.4	CC(=O)NCC1Cc2ccccc2N(C)C1	10.1021/acs.jmedchem.8b00359
		127041170	136689	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	584	15	2	4	6.1	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
		CHEMBL3740377	136689	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	584	15	2	4	6.1	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
		127026425	137820	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
		CHEMBL3759816	137820	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
		25210133	189561	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.7	COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		CHEMBL514427	189561	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.7	COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		71540393	86413	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	226	2	2	1	2.7	CNC(=O)N/C=C/c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
		CHEMBL2314254	86413	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	226	2	2	1	2.7	CNC(=O)N/C=C/c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
		44424021	142091	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	690	21	4	8	6.2	COc1ccc2[nH]c(C(=O)OCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
		CHEMBL388141	142091	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	690	21	4	8	6.2	COc1ccc2[nH]c(C(=O)OCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
		145969866	164841	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	546	15	3	6	4.8	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)c1	10.1021/acs.jmedchem.8b00893
		CHEMBL4218897	164841	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	546	15	3	6	4.8	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)c1	10.1021/acs.jmedchem.8b00893
		162644724	179394	0	None	57	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	321	5	1	4	3.0	COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
		CHEMBL4739898	179394	0	None	57	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	321	5	1	4	3.0	COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
		44264965	205339	1	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	286	5	2	4	4.0	CCOC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL7959	205339	1	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	286	5	2	4	4.0	CCOC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		44394556	124225	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	402	8	1	3	5.1	O=C(N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1)C1CC1	10.1016/j.bmcl.2004.07.055
		CHEMBL363441	124225	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	402	8	1	3	5.1	O=C(N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1)C1CC1	10.1016/j.bmcl.2004.07.055
		56671857	64453	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	384	13	1	4	4.3	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2ccccc2)c1	10.1016/j.bmc.2011.06.063
		CHEMBL1813324	64453	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	384	13	1	4	4.3	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2ccccc2)c1	10.1016/j.bmc.2011.06.063
		22718619	16774	0	None	7	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	7	1	3	3.8	CCCC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL124445	16774	0	None	7	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	7	1	3	3.8	CCCC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
		10089253	117085	0	None	-12	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	350	9	1	3	4.5	CC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL339265	117085	0	None	-12	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	350	9	1	3	4.5	CC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		145	140	49	None	-3	30	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
		1832	140	49	None	-3	30	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
		CHEMBL7257	140	49	None	-3	30	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
		DB14010	140	49	None	-3	30	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
		122178507	121324	0	None	13	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
		CHEMBL3580915	121324	0	None	13	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
		44317822	104876	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	315	8	1	3	3.7	CCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
		CHEMBL311106	104876	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	315	8	1	3	3.7	CCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
		10801655	21375	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	265	4	1	1	3.4	O=C(NCCC1Cc2cccc3cccc1c23)C1CC1	10.1021/jm000922c
		CHEMBL131431	21375	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	265	4	1	1	3.4	O=C(NCCC1Cc2cccc3cccc1c23)C1CC1	10.1021/jm000922c
		18360658	8890	0	None	-4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	518	13	2	5	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
		CHEMBL1097497	8890	0	None	-4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	518	13	2	5	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
		86272990	121327	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	245	3	2	4	1.4	COc1ccc2[nH]cc(Cc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
		CHEMBL3580918	121327	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	245	3	2	4	1.4	COc1ccc2[nH]cc(Cc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
		44394478	66289	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	404	8	1	3	5.3	CC(C)C(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
		CHEMBL184762	66289	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	404	8	1	3	5.3	CC(C)C(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
		10465460	208306	2	None	1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	202	3	2	1	1.8	CC(=O)NCCc1cc2ccccc2[nH]1	10.1021/jm001125h
		CHEMBL99083	208306	2	None	1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	202	3	2	1	1.8	CC(=O)NCCc1cc2ccccc2[nH]1	10.1021/jm001125h
		1355	3438	5	None	-70	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
		9806449	3438	5	None	-70	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
		CHEMBL14453	3438	5	None	-70	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
		16105169	174677	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2009.04.068
		CHEMBL455909	174677	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2009.04.068
		22718596	117373	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	322	7	1	3	4.3	CCCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL339784	117373	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	322	7	1	3	4.3	CCCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		11078652	207918	0	None	16	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	7	1	3	4.3	CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		CHEMBL96778	207918	0	None	16	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	7	1	3	4.3	CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		10517621	208064	0	None	11	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	290	3	1	2	3.3	CC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
		CHEMBL9765	208064	0	None	11	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	290	3	1	2	3.3	CC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
		122178513	121333	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	288	5	2	5	3.1	CCNc1nnc(Cc2c[nH]c3ccc(OC)cc23)s1	10.1021/acs.jmedchem.5b00245
		CHEMBL3580926	121333	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	288	5	2	5	3.1	CCNc1nnc(Cc2c[nH]c3ccc(OC)cc23)s1	10.1021/acs.jmedchem.5b00245
		16743123	93076	0	None	4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	270	5	1	2	3.0	CCC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
		CHEMBL244263	93076	0	None	4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	270	5	1	2	3.0	CCC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
		10518621	97315	0	None	11	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	304	4	1	2	3.7	CCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
		CHEMBL269175	97315	0	None	11	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	304	4	1	2	3.7	CCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
		10640625	208296	0	None	46	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	336	7	1	3	3.8	CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm001125h
		CHEMBL99002	208296	0	None	46	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	336	7	1	3	3.8	CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm001125h
		16105169	174677	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2009.04.068
		CHEMBL455909	174677	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2009.04.068
		16105169	174677	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2008.07.012
		CHEMBL455909	174677	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2008.07.012
		44412082	139279	0	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	300	5	2	3	3.2	CCCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
		CHEMBL379096	139279	0	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	300	5	2	3	3.2	CCCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
		10022570	168547	0	None	-13	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	378	10	1	3	5.1	CC(C)C(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL435586	168547	0	None	-13	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	378	10	1	3	5.1	CC(C)C(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		11131123	170633	0	None	12	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	323	6	1	3	3.7	COc1cccc(Cc2oc3ccccc3c2CCNC(C)=O)c1	10.1021/jm0005252
		CHEMBL445117	170633	0	None	12	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	323	6	1	3	3.7	COc1cccc(Cc2oc3ccccc3c2CCNC(C)=O)c1	10.1021/jm0005252
		56664925	64450	0	None	-53	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	498	17	2	6	3.8	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
		CHEMBL1813321	64450	0	None	-53	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	498	17	2	6	3.8	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
		11485537	135212	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	370	5	1	4	4.0	CCC(=O)NCc1cc2c(OC)cccc2n1C(=O)c1ccc(Cl)cc1	10.1021/jm048956y
		CHEMBL372243	135212	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	370	5	1	4	4.0	CCC(=O)NCc1cc2c(OC)cccc2n1C(=O)c1ccc(Cl)cc1	10.1021/jm048956y
		9805364	36963	0	None	-89	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	484	11	2	4	4.8	CC(=O)NCCc1cccc2ccc(OCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
		CHEMBL14514	36963	0	None	-89	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	484	11	2	4	4.8	CC(=O)NCCc1cccc2ccc(OCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
		16743125	92303	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	296	5	1	2	3.4	O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CCC1	10.1016/j.ejmech.2007.01.005
		CHEMBL242786	92303	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	296	5	1	2	3.4	O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CCC1	10.1016/j.ejmech.2007.01.005
		44358217	27512	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	287	3	2	3	1.7	O=C(NC1CC1)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		CHEMBL136894	27512	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	287	3	2	3	1.7	O=C(NC1CC1)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		145971624	164613	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	517	15	2	5	6.0	CCC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
		CHEMBL4215980	164613	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	517	15	2	5	6.0	CCC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
		10301190	8565	0	None	-7	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	511	12	1	5	6.2	COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1	10.1016/j.bmc.2010.04.008
		CHEMBL1094545	8565	0	None	-7	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	511	12	1	5	6.2	COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1	10.1016/j.bmc.2010.04.008
		12004056	174222	0	None	-13	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	340	6	3	3	2.0	CC(=O)NCCc1c(Br)[nH]c2ccc(OCCO)cc12	10.1016/j.ejmech.2019.111847
		CHEMBL4548591	174222	0	None	-13	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	340	6	3	3	2.0	CC(=O)NCCc1c(Br)[nH]c2ccc(OCCO)cc12	10.1016/j.ejmech.2019.111847
		81689735	121325	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
		CHEMBL3580916	121325	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
		118712372	114152	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	308	2	1	2	3.4	CCNC(=O)N1CCCC2Cc3cc(Cl)c(OC)cc3C21	10.1016/j.ejmech.2014.09.038
		CHEMBL3329390	114152	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	308	2	1	2	3.4	CCNC(=O)N1CCCC2Cc3cc(Cl)c(OC)cc3C21	10.1016/j.ejmech.2014.09.038
		16094577	83478	4	None	2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	297	7	1	2	3.5	CCC(=O)NCC(Cc1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
		CHEMBL220136	83478	4	None	2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	297	7	1	2	3.5	CCC(=O)NCC(Cc1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
		11418246	62403	0	None	4	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	403	6	1	3	5.8	O=C(NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12)C1CCC1	10.1016/j.ejmech.2011.02.044
		CHEMBL1779806	62403	0	None	4	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	403	6	1	3	5.8	O=C(NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12)C1CCC1	10.1016/j.ejmech.2011.02.044
		10946222	194741	0	None	43	2	Human	6.7	pKi	=	6.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	291	5	1	5	1.8	COc1ccc2c(c(CCNC(C)=O)cn2C)c1[N+](=O)[O-]	10.1021/jm011053+
		CHEMBL53622	194741	0	None	43	2	Human	6.7	pKi	=	6.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	291	5	1	5	1.8	COc1ccc2c(c(CCNC(C)=O)cn2C)c1[N+](=O)[O-]	10.1021/jm011053+
		11208632	122905	1	None	2	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	294	4	1	2	3.5	CCC(=O)NCCN1c2ccccc2CCc2ccccc21	10.1021/jm040768k
		CHEMBL360600	122905	1	None	2	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	294	4	1	2	3.5	CCC(=O)NCCN1c2ccccc2CCc2ccccc21	10.1021/jm040768k
		11014883	208128	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	400	6	1	3	4.1	COc1ccc2c(Br)c(CCNC(C)=O)n(Cc3ccccc3)c2c1	10.1021/jm001125h
		CHEMBL98028	208128	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	400	6	1	3	4.1	COc1ccc2c(Br)c(CCNC(C)=O)n(Cc3ccccc3)c2c1	10.1021/jm001125h
		90666309	109386	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CCC3)c2c1	10.1039/C1MD00149C
		CHEMBL3219330	109386	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CCC3)c2c1	10.1039/C1MD00149C
		11581340	122341	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	363	8	1	2	4.6	CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		CHEMBL359921	122341	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	363	8	1	2	4.6	CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		20590652	129978	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	391	10	1	2	5.4	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		CHEMBL367604	129978	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	391	10	1	2	5.4	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		20590654	130170	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	377	9	1	2	5.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		CHEMBL367797	130170	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	377	9	1	2	5.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		137637884	156246	0	None	10	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.3	CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
		CHEMBL4064813	156246	0	None	10	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.3	CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
		10424693	109643	1	None	2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	297	4	1	2	3.1	COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1	10.1039/C5MD00190K
		CHEMBL322339	109643	1	None	2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	297	4	1	2	3.1	COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1	10.1039/C5MD00190K
		127038129	136872	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	311	5	1	2	3.3	COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1	10.1039/C5MD00190K
		CHEMBL3742090	136872	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	311	5	1	2	3.3	COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1	10.1039/C5MD00190K
		145983175	166431	0	None	3	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	314	4	2	2	3.4	CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4277390	166431	0	None	3	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	314	4	2	2	3.4	CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		145988801	167046	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	283	4	1	2	3.4	COc1ccc2ccc3c(c2c1)C(CCNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
		CHEMBL4288925	167046	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	283	4	1	2	3.4	COc1ccc2ccc3c(c2c1)C(CCNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
		44358231	26948	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	275	3	2	3	1.5	CCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		CHEMBL136431	26948	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	275	3	2	3	1.5	CCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		44264962	204850	0	None	46	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	283	5	1	3	4.0	C/C=C/C(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL7559	204850	0	None	46	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	283	5	1	3	4.0	C/C=C/C(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		127025783	137738	0	None	4	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1	10.1016/j.ejmech.2015.12.047
		CHEMBL3759160	137738	0	None	4	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1	10.1016/j.ejmech.2015.12.047
		46885285	8167	0	None	186	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	265	8	1	3	2.6	CCCOc1ccc(OC)cc1CCCNC(C)=O	10.1016/j.bmcl.2010.02.084
		CHEMBL1091894	8167	0	None	186	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	265	8	1	3	2.6	CCCOc1ccc(OC)cc1CCCNC(C)=O	10.1016/j.bmcl.2010.02.084
		44429451	149212	0	None	15	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	352	6	1	3	3.4	CCCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		CHEMBL394406	149212	0	None	15	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	352	6	1	3	3.4	CCCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		168296374	192518	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
		CHEMBL5209359	192518	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
		10038243	116961	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	3.0	CCCC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL338659	116961	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	3.0	CCCC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
		44272425	67327	0	None	-3	2	Human	8.7	pKi	=	8.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	300	5	2	3	3.1	CC(C)C1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1	10.1016/j.bmcl.2003.12.052
		CHEMBL18846	67327	0	None	-3	2	Human	8.7	pKi	=	8.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	300	5	2	3	3.1	CC(C)C1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1	10.1016/j.bmcl.2003.12.052
		44272406	69182	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	289	5	3	3	2.7	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CC)N2	10.1016/j.bmcl.2003.12.052
		CHEMBL19260	69182	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	289	5	3	3	2.7	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CC)N2	10.1016/j.bmcl.2003.12.052
		20355585	110865	6	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	280	4	2	2	2.8	COc1cc2c(CCNC(C)=O)c(C)[nH]c2cc1Cl	10.1021/jm401343c
		CHEMBL3260979	110865	6	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	280	4	2	2	2.8	COc1cc2c(CCNC(C)=O)c(C)[nH]c2cc1Cl	10.1021/jm401343c
		90666305	109382	0	None	125	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
		CHEMBL3219326	109382	0	None	125	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
		44241666	196096	0	None	6	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	351	7	2	3	3.5	COc1ccc2[nH]c(CN(C)c3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
		CHEMBL560865	196096	0	None	6	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	351	7	2	3	3.5	COc1ccc2[nH]c(CN(C)c3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
		44429450	87364	0	None	6	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	338	5	1	3	3.0	CCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		CHEMBL233310	87364	0	None	6	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	338	5	1	3	3.0	CCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		22718561	17255	0	None	3	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	5	1	3	2.5	CCc1nc2cccc(CCCNC(C)=O)c2o1	10.1016/j.bmcl.2004.04.082
		CHEMBL125665	17255	0	None	3	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	5	1	3	2.5	CCc1nc2cccc(CCCNC(C)=O)c2o1	10.1016/j.bmcl.2004.04.082
		10015474	18560	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	5	1	3	2.8	Cc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
		CHEMBL127596	18560	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	5	1	3	2.8	Cc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
		9893513	30961	0	None	-29	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	540	15	2	4	6.4	CC(=O)NCCc1cccc2ccc(OCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
		CHEMBL13985	30961	0	None	-29	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	540	15	2	4	6.4	CC(=O)NCCc1cccc2ccc(OCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
		10925526	112334	0	None	26	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	329	6	1	3	4.2	COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		CHEMBL329299	112334	0	None	26	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	329	6	1	3	4.2	COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		44272438	70309	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	302	5	2	3	3.3	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
		CHEMBL19441	70309	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	302	5	2	3	3.3	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
		16094584	83245	0	None	33	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1	10.1021/jm800974d
		CHEMBL218708	83245	0	None	33	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1	10.1021/jm800974d
		16094593	166044	0	None	91	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C\CNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
		CHEMBL425644	166044	0	None	91	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C\CNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
		25270146	30693	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	262	5	1	3	2.2	CCCC(=O)N[C@H]1CCN(c2cccc(OC)c2)C1	10.1016/j.bmcl.2003.09.030
		CHEMBL139497	30693	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	262	5	1	3	2.2	CCCC(=O)N[C@H]1CCN(c2cccc(OC)c2)C1	10.1016/j.bmcl.2003.09.030
		44358276	118972	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	289	4	2	3	1.9	CCCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		CHEMBL342393	118972	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	289	4	2	3	1.9	CCCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		15453093	86411	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	255	3	1	2	2.8	COc1ccc2ccccc2c1[C@@H]1C[C@H]1NC(C)=O	10.1016/j.bmcl.2012.11.069
		CHEMBL2314252	86411	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	255	3	1	2	2.8	COc1ccc2ccccc2c1[C@@H]1C[C@H]1NC(C)=O	10.1016/j.bmcl.2012.11.069
		16094588	136722	4	None	208	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	311	8	1	2	4.1	CCCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
		CHEMBL374075	136722	4	None	208	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	311	8	1	2	4.1	CCCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
		44429445	87532	0	None	6	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	274	5	1	3	2.6	CCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		CHEMBL233516	87532	0	None	6	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	274	5	1	3	2.6	CCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		10400294	18549	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	258	5	1	3	2.6	Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
		CHEMBL127570	18549	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	258	5	1	3	2.6	Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
		11536239	76702	1	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	260	4	2	2	2.6	COc1ccc2[nH]cc(C(C)(C)CNC(C)=O)c2c1	10.1021/jm0512544
		CHEMBL206472	76702	1	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	260	4	2	2	2.6	COc1ccc2[nH]cc(C(C)(C)CNC(C)=O)c2c1	10.1021/jm0512544
		49865321	15898	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NC[C@H](C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223195	15898	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NC[C@H](C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
		11046748	207937	0	None	19	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	365	8	1	4	3.9	C=CC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
		CHEMBL96916	207937	0	None	19	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	365	8	1	4	3.9	C=CC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
		20642483	30652	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	272	3	1	3	1.7	O=C(N[C@H]1CCN(c2cccc3c2CCO3)C1)C1CC1	10.1016/j.bmcl.2003.09.030
		CHEMBL139439	30652	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	272	3	1	3	1.7	O=C(N[C@H]1CCN(c2cccc3c2CCO3)C1)C1CC1	10.1016/j.bmcl.2003.09.030
		10332159	16794	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	5	1	3	2.6	CCC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL124577	16794	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	5	1	3	2.6	CCC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
		44394438	66964	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	375	9	1	2	5.6	CCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		CHEMBL186736	66964	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	375	9	1	2	5.6	CCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		11630146	78085	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	246	4	2	2	2.4	COc1ccc2[nH]cc(C(C)CNC(C)=O)c2c1	10.1021/jm0512544
		CHEMBL210147	78085	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	246	4	2	2	2.4	COc1ccc2[nH]cc(C(C)CNC(C)=O)c2c1	10.1021/jm0512544
		23642306	159073	1	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
		CHEMBL4097233	159073	1	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
		44389812	63002	0	None	-19	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	365	10	1	2	4.9	CCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		CHEMBL178678	63002	0	None	-19	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	365	10	1	2	4.9	CCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		44424024	85173	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	522	16	2	6	5.6	COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
		CHEMBL225301	85173	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	522	16	2	6	5.6	COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
		49865269	15878	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(O[C@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223129	15878	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(O[C@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
		16094591	83323	4	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.2	COc1cccc(C(CNC(C)=O)Cc2ccccc2)c1	10.1021/jm060850a
		CHEMBL219127	83323	4	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.2	COc1cccc(C(CNC(C)=O)Cc2ccccc2)c1	10.1021/jm060850a
		56661499	64424	0	None	-102	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	456	14	2	6	2.7	CC(=O)NCCN(C)c1cccc(OCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
		CHEMBL1813174	64424	0	None	-102	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	456	14	2	6	2.7	CC(=O)NCCN(C)c1cccc(OCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
		90666302	109379	0	None	11	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.4	COc1ccc2[nH]c(CN3CCc4ccccc4C3)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
		CHEMBL3219323	109379	0	None	11	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.4	COc1ccc2[nH]c(CN3CCc4ccccc4C3)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
		127038130	136623	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	347	8	1	2	4.5	CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12	10.1039/C5MD00190K
		CHEMBL3739824	136623	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	347	8	1	2	4.5	CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12	10.1039/C5MD00190K
		85880795	110868	0	None	-12	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	319	9	1	3	4.0	CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2	10.1021/jm401343c
		CHEMBL3260984	110868	0	None	-12	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	319	9	1	3	4.0	CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2	10.1021/jm401343c
		10714573	98493	0	None	12	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2CCCc2ccccc2-1	10.1021/jm980684+
		CHEMBL276005	98493	0	None	12	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2CCCc2ccccc2-1	10.1021/jm980684+
		22718571	16838	0	None	7	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	8	1	3	3.6	CCCC(=O)NCCCc1cccc2nc(CCC)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL124782	16838	0	None	7	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	8	1	3	3.6	CCCC(=O)NCCCc1cccc2nc(CCC)oc12	10.1016/j.bmcl.2004.04.082
		44349100	114811	0	None	-34	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	376	10	1	3	4.9	O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2004.04.082
		CHEMBL334079	114811	0	None	-34	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	376	10	1	3	4.9	O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2004.04.082
		137640743	157045	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1ccc2ccc(CCNC(C)=O)cc2n1	10.1016/j.ejmech.2016.12.013
		CHEMBL4073867	157045	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1ccc2ccc(CCNC(C)=O)cc2n1	10.1016/j.ejmech.2016.12.013
		44349100	114811	0	None	-34	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	376	10	1	3	4.9	O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1021/jm401343c
		CHEMBL334079	114811	0	None	-34	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	376	10	1	3	4.9	O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1021/jm401343c
		44357899	118681	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	274	4	1	3	2.1	CCCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		CHEMBL341705	118681	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	274	4	1	3	2.1	CCCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		86272984	121332	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	288	4	2	4	3.0	CCn1c(Cc2c[nH]c3ccc(OC)cc23)n[nH]c1=S	10.1021/acs.jmedchem.5b00245
		CHEMBL3580924	121332	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	288	4	2	4	3.0	CCn1c(Cc2c[nH]c3ccc(OC)cc23)n[nH]c1=S	10.1021/acs.jmedchem.5b00245
		10610443	208307	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	246	5	2	2	2.2	CCC(=O)NCCc1cc2c(OC)cccc2[nH]1	10.1021/jm001125h
		CHEMBL99084	208307	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	246	5	2	2	2.2	CCC(=O)NCCc1cc2c(OC)cccc2[nH]1	10.1021/jm001125h
		45268309	196271	0	None	4	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	303	7	2	3	2.3	CCN(C)Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2009.04.068
		CHEMBL561928	196271	0	None	4	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	303	7	2	3	2.3	CCN(C)Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2009.04.068
		10567427	4240	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	316	4	1	2	3.7	O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CC1	10.1021/jm980684+
		CHEMBL10043	4240	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	316	4	1	2	3.7	O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CC1	10.1021/jm980684+
		10853021	98137	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	3	1	2	3.9	CC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
		CHEMBL273623	98137	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	3	1	2	3.9	CC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
		127025786	137849	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12	10.1016/j.ejmech.2015.12.047
		CHEMBL3760044	137849	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12	10.1016/j.ejmech.2015.12.047
		139451784	185395	0	None	-6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	317	7	1	5	2.4	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1	10.1021/acs.jmedchem.0c00627
		CHEMBL4860729	185395	0	None	-6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	317	7	1	5	2.4	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1	10.1021/acs.jmedchem.0c00627
		12985490	181220	0	None	12	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	349	6	2	3	3.7	COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		CHEMBL476132	181220	0	None	12	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	349	6	2	3	3.7	COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		10390684	11330	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	359	9	1	3	3.0	CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
		CHEMBL1179488	11330	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	359	9	1	3	3.0	CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
		CHEMBL78338	11330	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	359	9	1	3	3.0	CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
		10069719	193398	4	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	403	5	2	4	2.4	COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1[N+](=O)[O-]	10.1021/jm011053+
		CHEMBL52559	193398	4	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	403	5	2	4	2.4	COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1[N+](=O)[O-]	10.1021/jm011053+
		162673916	183034	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	327	6	1	5	2.9	COc1ccc2[nH]cc(CCc3nn(CC4CCC4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
		CHEMBL4793947	183034	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	327	6	1	5	2.9	COc1ccc2[nH]cc(CCc3nn(CC4CCC4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
		46885229	7706	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	375	9	1	3	4.6	COc1ccc(OCc2ccccc2)c(CCCNC(=O)c2ccccc2)c1	10.1016/j.bmcl.2010.02.084
		CHEMBL1088826	7706	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	375	9	1	3	4.6	COc1ccc(OCc2ccccc2)c(CCCNC(=O)c2ccccc2)c1	10.1016/j.bmcl.2010.02.084
		16743464	92326	0	None	11	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	310	3	1	2	3.9	CC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1	10.1016/j.ejmech.2007.01.005
		CHEMBL243002	92326	0	None	11	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	310	3	1	2	3.9	CC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1	10.1016/j.ejmech.2007.01.005
		44412141	76743	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	312	4	2	3	3.2	Cn1cc(C2(CNC(=O)C3CCC3)CCC2)c2cc(O)ccc21	10.1021/jm0512544
		CHEMBL206686	76743	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	312	4	2	3	3.2	Cn1cc(C2(CNC(=O)C3CCC3)CCC2)c2cc(O)ccc21	10.1021/jm0512544
		49865266	15875	2	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1ccc(SCCNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
		CHEMBL1223126	15875	2	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1ccc(SCCNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
		127025782	137731	0	None	6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	297	4	1	3	3.9	COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1	10.1016/j.ejmech.2015.12.047
		CHEMBL3759054	137731	0	None	6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	297	4	1	3	3.9	COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1	10.1016/j.ejmech.2015.12.047
		25210134	189624	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	315	6	2	3	2.5	COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		CHEMBL514904	189624	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	315	6	2	3	2.5	COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		53231367	62405	0	None	117	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	425	8	1	3	6.0	O=C(CCCCl)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
		CHEMBL1779808	62405	0	None	117	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	425	8	1	3	6.0	O=C(CCCCl)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
		11045144	208282	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	310	4	2	2	3.0	CCC(=O)NCc1[nH]c2cc(OC)ccc2c1Br	10.1021/jm001125h
		CHEMBL98956	208282	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	310	4	2	2	3.0	CCC(=O)NCc1[nH]c2cc(OC)ccc2c1Br	10.1021/jm001125h
		56662799	64456	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	526	15	2	6	2.9	COc1cccc(N(CCNC(C)=O)C(=O)CCCCC(=O)N(CCNC(C)=O)c2cccc(OC)c2)c1	10.1016/j.bmc.2011.06.063
		CHEMBL1813327	64456	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	526	15	2	6	2.9	COc1cccc(N(CCNC(C)=O)C(=O)CCCCC(=O)N(CCNC(C)=O)c2cccc(OC)c2)c1	10.1016/j.bmc.2011.06.063
		9888609	8892	0	None	-46	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO-K1 cells after 2 hrsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO-K1 cells after 2 hrs	ChEMBL	424	7	2	2	5.0	CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1039/C5MD00190K
		CHEMBL1097525	8892	0	None	-46	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO-K1 cells after 2 hrsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO-K1 cells after 2 hrs	ChEMBL	424	7	2	2	5.0	CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1039/C5MD00190K
		9888609	8892	0	None	-46	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	424	7	2	2	5.0	CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm401343c
		CHEMBL1097525	8892	0	None	-46	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	424	7	2	2	5.0	CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm401343c
		25210134	189624	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	315	6	2	3	2.5	COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		CHEMBL514904	189624	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	315	6	2	3	2.5	COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		162668689	182758	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	285	5	1	4	2.2	COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
		CHEMBL4790145	182758	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	285	5	1	4	2.2	COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
		44264857	205109	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	286	5	2	3	3.6	CCNC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL7772	205109	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	286	5	2	3	3.6	CCNC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		137646628	157578	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
		CHEMBL4080608	157578	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
		11602301	76701	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	326	5	1	3	3.5	COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCCC1)cn2C	10.1021/jm0512544
		CHEMBL206471	76701	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	326	5	1	3	3.5	COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCCC1)cn2C	10.1021/jm0512544
		44349258	16917	1	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	261	5	2	3	2.4	CCNC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL125226	16917	1	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	261	5	2	3	2.4	CCNC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
		137660180	159122	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	270	5	1	3	2.3	COc1cnc2cccc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2016.12.013
		CHEMBL4097817	159122	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	270	5	1	3	2.3	COc1cnc2cccc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2016.12.013
		CHEMBL3109560	211088	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells after 120 mins	ChEMBL		None	None	None		COc1ccc(/C=C/C2=[N+]3C(=Cc4c(CCNC(C)=O)c5cc(OC)ccc5n4[B-]3(F)F)C=C2)cc1	10.1021/ml4004155
		46885283	8255	0	None	48	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	237	6	1	3	1.8	COc1ccc(OC)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
		CHEMBL1092400	8255	0	None	48	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	237	6	1	3	1.8	COc1ccc(OC)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
		25210000	189494	0	None	11	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	408	7	2	5	3.3	COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		CHEMBL513933	189494	0	None	11	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	408	7	2	5	3.3	COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		49865323	15900	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NC[C@@H](C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223197	15900	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NC[C@@H](C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
		25210000	189494	0	None	11	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	408	7	2	5	3.3	COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		CHEMBL513933	189494	0	None	11	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	408	7	2	5	3.3	COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		9925874	162230	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	285	6	1	3	4.2	CCCC(=O)Nc1cccc(Oc2cccc(OC)c2)c1	10.1016/j.bmcl.2003.11.030
		CHEMBL416328	162230	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	285	6	1	3	4.2	CCCC(=O)Nc1cccc(Oc2cccc(OC)c2)c1	10.1016/j.bmcl.2003.11.030
		145975938	163899	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	519	14	3	6	5.4	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(O)c3)c2)c1	10.1021/acs.jmedchem.8b00893
		CHEMBL4207166	163899	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	519	14	3	6	5.4	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(O)c3)c2)c1	10.1021/acs.jmedchem.8b00893
		162674710	183334	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	270	3	1	4	2.4	COc1ccc2c(c1)C(/C=C/c1n[nH]c(=O)o1)=CCC2	10.1016/j.ejmech.2020.112090
		CHEMBL4797429	183334	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	270	3	1	4	2.4	COc1ccc2c(c1)C(/C=C/c1n[nH]c(=O)o1)=CCC2	10.1016/j.ejmech.2020.112090
		46935149	15851	2	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC(C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223051	15851	2	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC(C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
		49865378	15935	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC[C@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223281	15935	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC[C@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
		22718661	16839	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	7	1	3	3.2	CCCc1nc2cccc(CCCNC(=O)CC)c2o1	10.1016/j.bmcl.2004.04.082
		CHEMBL124783	16839	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	7	1	3	3.2	CCCc1nc2cccc(CCCNC(=O)CC)c2o1	10.1016/j.bmcl.2004.04.082
		24749950	3916	8	None	588	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C	10.1021/jm700957j
		7923	3916	8	None	588	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C	10.1021/jm700957j
		CHEMBL394676	3916	8	None	588	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C	10.1021/jm700957j
		46885288	8329	0	None	95	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1ccc(COc2ccc(OC)cc2CCCNC(C)=O)cc1	10.1016/j.bmcl.2010.02.084
		CHEMBL1092839	8329	0	None	95	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1ccc(COc2ccc(OC)cc2CCCNC(C)=O)cc1	10.1016/j.bmcl.2010.02.084
		10903368	208104	0	None	4	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2ccc(OC)cc2n1Cc1ccccc1	10.1021/jm001125h
		CHEMBL97885	208104	0	None	4	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2ccc(OC)cc2n1Cc1ccccc1	10.1021/jm001125h
		164946945	190229	1	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
		CHEMBL5174929	190229	1	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
		11529521	76759	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	298	5	2	2	3.1	COc1ccc2[nH]cc(C3(CNC(=O)C4CC4)CCC3)c2c1	10.1021/jm0512544
		CHEMBL206790	76759	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	298	5	2	2	3.1	COc1ccc2[nH]cc(C3(CNC(=O)C4CC4)CCC3)c2c1	10.1021/jm0512544
		162645859	179707	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	315	3	1	5	1.5	CCNC(=O)N1CCN(c2ncnc3ccc(OC)cc23)CC1	10.1016/j.ejmech.2020.112078
		CHEMBL4743884	179707	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	315	3	1	5	1.5	CCNC(=O)N1CCN(c2ncnc3ccc(OC)cc23)CC1	10.1016/j.ejmech.2020.112078
		10657206	119689	2	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	2.2	CCC(=O)NCc1cc2c(OC)cccc2[nH]1	10.1021/jm001125h
		CHEMBL34728	119689	2	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	2.2	CCC(=O)NCc1cc2c(OC)cccc2[nH]1	10.1021/jm001125h
		11326232	127424	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	372	6	1	5	2.9	CCC(=O)NCc1cc2c(OC)cccc2n1S(=O)(=O)c1ccccc1	10.1021/jm048956y
		CHEMBL366004	127424	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	372	6	1	5	2.9	CCC(=O)NCc1cc2c(OC)cccc2n1S(=O)(=O)c1ccccc1	10.1021/jm048956y
		10091075	17281	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	378	11	1	3	5.2	CCCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL125705	17281	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	378	11	1	3	5.2	CCCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		22718654	113332	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	7	1	3	3.5	CCCc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
		CHEMBL331636	113332	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	7	1	3	3.5	CCCc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
		85880795	110868	0	None	-12	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to MT2 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK cells	ChEMBL	319	9	1	3	4.0	CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2	10.1021/jm401343c
		CHEMBL3260984	110868	0	None	-12	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to MT2 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK cells	ChEMBL	319	9	1	3	4.0	CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2	10.1021/jm401343c
		11065731	101881	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1cc([N+](=O)[O-])c2[nH]cc(CCNC(C)=O)c2c1	10.1021/jm011053+
		CHEMBL300729	101881	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1cc([N+](=O)[O-])c2[nH]cc(CCNC(C)=O)c2c1	10.1021/jm011053+
		145976375	163797	0	None	-10	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	525	15	2	6	5.7	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1	10.1021/acs.jmedchem.8b00893
		CHEMBL4206000	163797	0	None	-10	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	525	15	2	6	5.7	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1	10.1021/acs.jmedchem.8b00893
		145990308	167032	0	None	13	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	328	5	2	2	3.8	CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4288690	167032	0	None	13	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	328	5	2	2	3.8	CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		145986700	167219	0	None	1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	328	4	2	2	3.5	CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4292109	167219	0	None	1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	328	4	2	2	3.5	CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		139451767	185004	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
		CHEMBL4854625	185004	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
		11776674	116649	1	None	1	2	Human	8.5	pKi	=	8.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	246	4	1	3	1.9	COc1ccc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm011053+
		CHEMBL33700	116649	1	None	1	2	Human	8.5	pKi	=	8.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	246	4	1	3	1.9	COc1ccc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm011053+
		139451799	185839	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	279	5	1	5	1.9	COc1ccc2nc(SC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
		CHEMBL4867553	185839	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	279	5	1	5	1.9	COc1ccc2nc(SC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
		10938056	107058	0	None	2	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	393	11	1	3	5.7	CCCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		CHEMBL315653	107058	0	None	2	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	393	11	1	3	5.7	CCCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		11637615	77247	0	None	2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	272	4	2	2	2.7	COc1ccc2[nH]cc(C3(CNC(C)=O)CCC3)c2c1	10.1021/jm0512544
		CHEMBL207960	77247	0	None	2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	272	4	2	2	2.7	COc1ccc2[nH]cc(C3(CNC(C)=O)CCC3)c2c1	10.1021/jm0512544
		71508234	705	0	None	38	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
		7924	705	0	None	38	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
		CHEMBL2326202	705	0	None	38	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
		10427851	181833	0	None	407	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	348	6	2	3	3.7	COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		CHEMBL477834	181833	0	None	407	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	348	6	2	3	3.7	COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		122193492	123942	0	None	3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	261	4	1	4	1.5	COc1ccc2oc(=O)cc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2015.09.003
		CHEMBL3628489	123942	0	None	3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	261	4	1	4	1.5	COc1ccc2oc(=O)cc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2015.09.003
		189748	16816	9	None	60	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	262	5	2	3	1.9	COc1cc2[nH]cc(CCNC(C)=O)c2cc1OC	10.1021/jm401343c
		CHEMBL124699	16816	9	None	60	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells	ChEMBL	262	5	2	3	1.9	COc1cc2[nH]cc(CCNC(C)=O)c2cc1OC	10.1021/jm401343c
		11088627	207545	0	None	8	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	324	6	1	4	3.1	COc1ccc2oc(Cc3cccnc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		CHEMBL94745	207545	0	None	8	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	324	6	1	4	3.1	COc1ccc2oc(Cc3cccnc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		44349108	16864	0	None	2	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	6	1	3	2.7	CCCC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
		CHEMBL124914	16864	0	None	2	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	6	1	3	2.7	CCCC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
		10711649	207784	0	None	19	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	332	5	1	2	4.3	CCCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
		CHEMBL9605	207784	0	None	19	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	332	5	1	2	4.3	CCCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
		90666306	109383	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12	10.1039/C1MD00149C
		CHEMBL3219327	109383	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12	10.1039/C1MD00149C
		24750194	89948	0	None	87	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	324	7	1	3	3.8	COc1cccc(N(CCNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm700957j
		CHEMBL238049	89948	0	None	87	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	324	7	1	3	3.8	COc1cccc(N(CCNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm700957j
		49865319	15896	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NCC(C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223193	15896	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NCC(C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
		137644121	158149	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	291	4	1	1	4.0	CCC(=O)NCC1=C(c2ccccc2)c2ccccc2CC1	10.1021/acs.jmedchem.8b00359
		CHEMBL4087265	158149	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	291	4	1	1	4.0	CCC(=O)NCC1=C(c2ccccc2)c2ccccc2CC1	10.1021/acs.jmedchem.8b00359
		86273227	121317	0	None	3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	242	4	2	2	1.5	C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
		CHEMBL3580907	121317	0	None	3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	242	4	2	2	1.5	C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
		10800029	116710	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	3	1	1	3.0	CC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
		CHEMBL337295	116710	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	3	1	1	3.0	CC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
		24750190	89885	1	None	32	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	254	5	1	2	3.0	CC(=O)NCCN(c1ccccc1)c1ccccc1	10.1021/jm700957j
		CHEMBL237840	89885	1	None	32	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	254	5	1	2	3.0	CC(=O)NCCN(c1ccccc1)c1ccccc1	10.1021/jm700957j
		139451780	185944	0	None	-5	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	303	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1	10.1021/acs.jmedchem.0c00627
		CHEMBL4869463	185944	0	None	-5	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	303	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1	10.1021/acs.jmedchem.0c00627
		44389845	64832	0	None	-15	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	377	10	1	2	4.9	O=C(NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1	10.1016/j.bmcl.2005.01.015
		CHEMBL181974	64832	0	None	-15	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	377	10	1	2	4.9	O=C(NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1	10.1016/j.bmcl.2005.01.015
		44389813	131374	0	None	-15	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	379	11	1	2	5.3	CCCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		CHEMBL368886	131374	0	None	-15	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	379	11	1	2	5.3	CCCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		54582195	60762	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	329	5	1	5	1.9	COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		CHEMBL1760955	60762	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	329	5	1	5	1.9	COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		25209999	175518	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	441	6	2	3	4.2	COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		CHEMBL457807	175518	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	441	6	2	3	4.2	COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		11173131	124098	0	None	7	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	265	2	1	1	3.1	CC(=O)NCC1Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
		CHEMBL363321	124098	0	None	7	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	265	2	1	1	3.1	CC(=O)NCC1Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
		25209999	175518	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	441	6	2	3	4.2	COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		CHEMBL457807	175518	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	441	6	2	3	4.2	COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
		162667374	182555	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	357	10	1	5	4.1	CCCCCCCn1nc(CCc2c[nH]c3ccc(OC)cc23)oc1=O	10.1016/j.ejmech.2020.112090
		CHEMBL4787595	182555	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	357	10	1	5	4.1	CCCCCCCn1nc(CCc2c[nH]c3ccc(OC)cc23)oc1=O	10.1016/j.ejmech.2020.112090
		44429452	87365	0	None	4	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	308	5	2	2	3.5	COc1cc(-c2ccccc2)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
		CHEMBL233311	87365	0	None	4	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	308	5	2	2	3.5	COc1cc(-c2ccccc2)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
		49865375	15932	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC[C@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223278	15932	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC[C@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
		10737123	97380	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	358	4	1	2	4.7	O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CCC1	10.1021/jm980684+
		CHEMBL269670	97380	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	358	4	1	2	4.7	O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CCC1	10.1021/jm980684+
		56662798	64455	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	554	21	2	6	5.4	COc1cccc(N(CCCCCCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1	10.1016/j.bmc.2011.06.063
		CHEMBL1813326	64455	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	554	21	2	6	5.4	COc1cccc(N(CCCCCCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1	10.1016/j.bmc.2011.06.063
		11794657	208321	0	None	23	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	388	5	1	3	4.7	COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
		CHEMBL9917	208321	0	None	23	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	388	5	1	3	4.7	COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
		CHEMBL3109561	211089	0	None	-6	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells after 120 mins	ChEMBL		None	None	None		COc1ccc(C2=[N+]3C(=Cc4c(CCNC(C)=O)c5cc(OC)ccc5n4[B-]3(F)F)C=C2)cc1	10.1021/ml4004155
		11680808	77079	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	286	5	2	2	3.1	CCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1	10.1021/jm0512544
		CHEMBL207420	77079	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	286	5	2	2	3.1	CCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1	10.1021/jm0512544
		145978811	163860	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	531	16	2	5	6.4	CC(=O)NCCN(C)c1cccc(OCCCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
		CHEMBL4206642	163860	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	531	16	2	5	6.4	CC(=O)NCCN(C)c1cccc(OCCCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
		162668486	182574	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	377	8	1	5	3.7	COc1ccc2[nH]cc(CCc3nn(CCCc4ccccc4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
		CHEMBL4787877	182574	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	377	8	1	5	3.7	COc1ccc2[nH]cc(CCc3nn(CCCc4ccccc4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
		10595585	98546	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	374	5	1	3	4.3	COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCc2ccccc2-1	10.1021/jm980684+
		CHEMBL276490	98546	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	374	5	1	3	4.3	COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCc2ccccc2-1	10.1021/jm980684+
		162646341	179500	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	312	3	0	5	1.7	COc1ccc2ncnc(N3CCN(C(=O)C4CC4)CC3)c2c1	10.1016/j.ejmech.2020.112078
		CHEMBL4741114	179500	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	312	3	0	5	1.7	COc1ccc2ncnc(N3CCN(C(=O)C4CC4)CC3)c2c1	10.1016/j.ejmech.2020.112078
		9817692	205661	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	297	6	1	3	3.7	CCCC(=O)Nc1ccc(C(=O)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL8200	205661	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	297	6	1	3	3.7	CCCC(=O)Nc1ccc(C(=O)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		44394394	122710	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	387	9	1	2	5.6	O=C(NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12)C1CC1	10.1016/j.bmcl.2004.07.055
		CHEMBL360428	122710	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	387	9	1	2	5.6	O=C(NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12)C1CC1	10.1016/j.bmcl.2004.07.055
		11515177	141060	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	314	5	1	3	3.4	COc1ccc2c(c1)c(C(C)(C)CNC(=O)C1CCC1)cn2C	10.1021/jm0512544
		CHEMBL382439	141060	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	314	5	1	3	3.4	COc1ccc2c(c1)c(C(C)(C)CNC(=O)C1CCC1)cn2C	10.1021/jm0512544
		145963877	164256	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	503	14	2	5	5.7	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
		CHEMBL4211530	164256	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	503	14	2	5	5.7	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
		44587356	193384	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	423	8	3	5	2.8	COc1ccc2c(c1)CC(CO)N2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2008.07.012
		CHEMBL525374	193384	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	423	8	3	5	2.8	COc1ccc2c(c1)CC(CO)N2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2008.07.012
		90666308	109385	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	389	7	2	3	3.8	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CC3)c2c1	10.1039/C1MD00149C
		CHEMBL3219329	109385	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	389	7	2	3	3.8	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CC3)c2c1	10.1039/C1MD00149C
		10520058	98138	0	None	8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	324	3	1	2	4.0	CC(=O)NCCc1c2n(c3ccc(Cl)cc13)Cc1ccccc1-2	10.1021/jm980684+
		CHEMBL273624	98138	0	None	8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	324	3	1	2	4.0	CC(=O)NCCc1c2n(c3ccc(Cl)cc13)Cc1ccccc1-2	10.1021/jm980684+
		145968467	164789	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	400	13	2	5	4.0	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(O)c2)c1	10.1021/acs.jmedchem.8b00893
		CHEMBL4218247	164789	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	400	13	2	5	4.0	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(O)c2)c1	10.1021/acs.jmedchem.8b00893
		13250272	15874	17	None	11	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	195	4	1	2	1.9	CC(=O)NCCSc1ccccc1	10.1016/j.bmc.2010.06.100
		CHEMBL1223125	15874	17	None	11	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	195	4	1	2	1.9	CC(=O)NCCSc1ccccc1	10.1016/j.bmc.2010.06.100
		10950593	111521	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	459	6	1	3	5.7	COc1ccc2oc(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		CHEMBL327864	111521	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	459	6	1	3	5.7	COc1ccc2oc(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		49865373	15930	2	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OCC(C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223276	15930	2	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OCC(C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
		9860296	29217	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	272	3	1	3	1.7	O=C(N[C@@H]1CCN(c2cccc3c2CCO3)C1)C1CC1	10.1016/j.bmcl.2003.09.030
		CHEMBL138228	29217	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	272	3	1	3	1.7	O=C(N[C@@H]1CCN(c2cccc3c2CCO3)C1)C1CC1	10.1016/j.bmcl.2003.09.030
		22718579	16522	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	5	1	3	3.0	CC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL123690	16522	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	5	1	3	3.0	CC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
		22718521	16653	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	2.8	CCCc1nc2cccc(CCCNC(C)=O)c2o1	10.1016/j.bmcl.2004.04.082
		CHEMBL124216	16653	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	2.8	CCCc1nc2cccc(CCCNC(C)=O)c2o1	10.1016/j.bmcl.2004.04.082
		21581653	138043	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.3	COc1cc2c(CCNC(C)=O)c[nH]c2cn1	10.1016/j.ejmech.2016.01.008
		CHEMBL3765249	138043	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.3	COc1cc2c(CCNC(C)=O)c[nH]c2cn1	10.1016/j.ejmech.2016.01.008
		10638747	208367	0	None	11	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	310	4	2	2	2.6	COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1	10.1021/jm001125h
		CHEMBL99512	208367	0	None	11	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	310	4	2	2	2.6	COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1	10.1021/jm001125h
		1362	3437	22	None	-39	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
		9870523	3437	22	None	-39	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
		CHEMBL429392	3437	22	None	-39	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
		10736247	208363	0	None	5	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	344	4	1	2	4.3	O=C(NCCc1c2n(c3ccccc13)CCc1ccccc1-2)C1CCC1	10.1021/jm980684+
		CHEMBL9950	208363	0	None	5	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	344	4	1	2	4.3	O=C(NCCc1c2n(c3ccccc13)CCc1ccccc1-2)C1CCC1	10.1021/jm980684+
		44349329	18548	1	None	13	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	289	7	2	3	3.0	CCCc1nc2cccc(CCCNC(=O)NCC)c2o1	10.1016/j.bmcl.2004.04.082
		CHEMBL127565	18548	1	None	13	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	289	7	2	3	3.0	CCCc1nc2cccc(CCCNC(=O)NCC)c2o1	10.1016/j.bmcl.2004.04.082
		44587357	188150	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	393	7	3	4	2.8	COc1ccc2[nH]c(CN3c4ccccc4CC3CO)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.07.012
		CHEMBL498494	188150	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	393	7	3	4	2.8	COc1ccc2[nH]c(CN3c4ccccc4CC3CO)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.07.012
		10709646	207833	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	304	3	1	2	3.5	CC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
		CHEMBL9634	207833	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	304	3	1	2	3.5	CC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
		56671858	64454	0	None	20	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	498	17	2	6	3.8	COc1cccc(N(CCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1	10.1016/j.bmc.2011.06.063
		CHEMBL1813325	64454	0	None	20	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	498	17	2	6	3.8	COc1cccc(N(CCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1	10.1016/j.bmc.2011.06.063
		10948786	207800	0	None	18	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	375	7	1	4	4.6	COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)c3ccco3)c2c1	10.1021/jm0005252
		CHEMBL96173	207800	0	None	18	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	375	7	1	4	4.6	COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)c3ccco3)c2c1	10.1021/jm0005252
		11624018	140888	0	None	-5	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	326	5	1	3	3.5	COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCC1)cn2C	10.1021/jm0512544
		CHEMBL382050	140888	0	None	-5	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	326	5	1	3	3.5	COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCC1)cn2C	10.1021/jm0512544
		44349305	171136	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	320	6	1	3	4.0	O=C(NCCCc1cccc2nc(-c3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2004.04.082
		CHEMBL445840	171136	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	320	6	1	3	4.0	O=C(NCCCc1cccc2nc(-c3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2004.04.082
		11393103	125804	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	322	5	1	3	3.8	CCC(=O)NCCN1c2ccccc2C=Cc2ccc(OC)cc21	10.1021/jm040768k
		CHEMBL364806	125804	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	322	5	1	3	3.8	CCC(=O)NCCN1c2ccccc2C=Cc2ccc(OC)cc21	10.1021/jm040768k
		118712360	114151	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	330	4	0	4	2.6	CCN(CC)C(=O)CN1CCCC2Cc3cc4c(cc3C21)OCO4	10.1016/j.ejmech.2014.09.038
		CHEMBL3329377	114151	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	330	4	0	4	2.6	CCN(CC)C(=O)CN1CCCC2Cc3cc4c(cc3C21)OCO4	10.1016/j.ejmech.2014.09.038
		12436514	15927	6	None	3	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)NC(C)COc1ccccc1	10.1016/j.bmc.2010.06.100
		CHEMBL1223273	15927	6	None	3	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)NC(C)COc1ccccc1	10.1016/j.bmc.2010.06.100
		44264983	205398	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	296	5	2	3	4.1	CCCC(=O)Nc1ccc(Nc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL8004	205398	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	296	5	2	3	4.1	CCCC(=O)Nc1ccc(Nc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
		11623375	138692	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	286	5	1	3	2.7	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1	10.1021/jm0512544
		CHEMBL377871	138692	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	286	5	1	3	2.7	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1	10.1021/jm0512544
		10454621	101880	4	None	47	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	417	5	1	5	2.4	COc1ccc2c(c(CCNC(C)=O)c(I)n2C)c1[N+](=O)[O-]	10.1021/jm011053+
		CHEMBL300728	101880	4	None	47	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	417	5	1	5	2.4	COc1ccc2c(c(CCNC(C)=O)c(I)n2C)c1[N+](=O)[O-]	10.1021/jm011053+
		44358035	29964	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	260	3	1	3	1.7	CCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		CHEMBL138848	29964	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	260	3	1	3	1.7	CCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		11392720	67051	0	None	4	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	309	4	1	2	3.5	COc1ccc2c(c1)C(CCNC(C)=O)Cc1ccccc1C2	10.1021/jm040768k
		CHEMBL187160	67051	0	None	4	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	309	4	1	2	3.5	COc1ccc2c(c1)C(CCNC(C)=O)Cc1ccccc1C2	10.1021/jm040768k
		168288029	191621	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	471	9	1	9	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
		CHEMBL5195595	191621	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	471	9	1	9	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
		49865265	15873	2	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1cccc(SCCNC(C)=O)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223124	15873	2	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1cccc(SCCNC(C)=O)c1	10.1016/j.bmc.2010.06.100
		162644334	181819	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	341	6	1	5	3.3	COc1ccc2[nH]cc(CCc3nn(CC4CCCC4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
		CHEMBL4778192	181819	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	341	6	1	5	3.3	COc1ccc2[nH]cc(CCc3nn(CC4CCCC4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
		162643514	181687	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2ncnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
		CHEMBL4776540	181687	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2ncnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
		145965883	164082	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	307	11	2	4	2.2	CC(=O)NCCN(C)c1cccc(OCCCCCCN)c1	10.1021/acs.jmedchem.8b00893
		CHEMBL4209446	164082	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	307	11	2	4	2.2	CC(=O)NCCN(C)c1cccc(OCCCCCCN)c1	10.1021/acs.jmedchem.8b00893
		122178509	121328	0	None	8	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
		CHEMBL3580919	121328	0	None	8	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
		137655435	158810	0	None	15	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1cnc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2016.12.013
		CHEMBL4094436	158810	0	None	15	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1cnc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2016.12.013
		122178509	121328	0	None	8	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
		CHEMBL3580919	121328	0	None	8	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
		9796251	118110	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCC(=O)NCCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
		CHEMBL340745	118110	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCC(=O)NCCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
		9839199	21363	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
		CHEMBL131424	21363	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
		9859913	205530	0	None	20	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	257	4	1	3	3.4	COc1cccc(Oc2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
		CHEMBL8094	205530	0	None	20	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	257	4	1	3	3.4	COc1cccc(Oc2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
		44264707	97171	1	None	19	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	256	4	2	3	3.4	COc1cccc(Nc2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
		CHEMBL268165	97171	1	None	19	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	256	4	2	3	3.4	COc1cccc(Nc2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
		127025787	137732	0	None	4	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	298	4	2	3	3.4	CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
		CHEMBL3759080	137732	0	None	4	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	298	4	2	3	3.4	CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
		46888522	8645	0	None	-11	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	513	12	1	5	6.2	COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1	10.1016/j.bmc.2010.04.008
		CHEMBL1095197	8645	0	None	-11	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	513	12	1	5	6.2	COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1	10.1016/j.bmc.2010.04.008
		22718532	16783	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	218	4	1	3	1.9	CC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
		CHEMBL124488	16783	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	218	4	1	3	1.9	CC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
		46935150	15879	0	None	-6	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(O[C@@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223130	15879	0	None	-6	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(O[C@@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
		11463056	62402	0	None	51	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	6	1	3	5.4	CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
		CHEMBL1779805	62402	0	None	51	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	377	6	1	3	5.4	CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
		11638009	165763	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	300	5	1	3	3.1	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1	10.1021/jm0512544
		CHEMBL424693	165763	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	300	5	1	3	3.1	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1	10.1021/jm0512544
		22718602	96544	0	None	2	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	6	1	3	3.1	CCc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
		CHEMBL262890	96544	0	None	2	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	6	1	3	3.1	CCc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
		139451761	184597	0	None	-4	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
		CHEMBL4848885	184597	0	None	-4	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
		53310838	63791	0	None	4	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.8	CC(=O)NCCn1c(-c2ccccc2)nc2ccc3c(c21)CCO3	10.1021/jm200385u
		CHEMBL1802021	63791	0	None	4	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.8	CC(=O)NCCn1c(-c2ccccc2)nc2ccc3c(c21)CCO3	10.1021/jm200385u
		168296374	192518	0	None	2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
		CHEMBL5209359	192518	0	None	2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
		145972981	164495	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	513	13	3	4	6.2	CC(=O)NCCc1c[nH]c2ccc(OCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12	10.1021/acs.jmedchem.8b00893
		CHEMBL4214478	164495	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	513	13	3	4	6.2	CC(=O)NCCc1c[nH]c2ccc(OCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12	10.1021/acs.jmedchem.8b00893
		44358238	119372	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	261	2	2	3	1.1	CNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		CHEMBL344449	119372	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	261	2	2	3	1.1	CNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		49865204	15850	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(O[C@@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223050	15850	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(O[C@@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
		44348996	17207	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	272	6	1	3	2.8	CCc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
		CHEMBL125642	17207	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	272	6	1	3	2.8	CCc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
		44264942	205444	0	None	19	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	313	5	1	4	4.0	CCCC(=O)Nc1ccc(Oc2cccc3c2OCCO3)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL8032	205444	0	None	19	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	313	5	1	4	4.0	CCCC(=O)Nc1ccc(Oc2cccc3c2OCCO3)cc1	10.1016/j.bmcl.2003.11.030
		44264844	204862	0	None	2	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	296	5	1	3	3.8	COc1cccc(N(C)c2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
		CHEMBL7567	204862	0	None	2	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	296	5	1	3	3.8	COc1cccc(N(C)c2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
		44424023	144814	0	None	14	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	346	9	2	4	3.2	CCCCCOC(=O)c1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2007.03.080
		CHEMBL390944	144814	0	None	14	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	346	9	2	4	3.2	CCCCCOC(=O)c1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2007.03.080
		53231465	62400	0	None	5	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	237	3	1	2	2.7	CC(=O)NCCc1csc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
		CHEMBL1779803	62400	0	None	5	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	237	3	1	2	2.7	CC(=O)NCCc1csc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
		86273229	121319	1	None	3	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	244	5	2	2	2.0	C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
		CHEMBL3580909	121319	1	None	3	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	244	5	2	2	2.0	C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
		44389864	64336	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	380	10	2	2	4.7	CCNC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		CHEMBL181192	64336	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	380	10	2	2	4.7	CCNC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		44389839	64601	0	None	-10	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	379	10	1	2	5.1	CC(C)C(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		CHEMBL181687	64601	0	None	-10	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	379	10	1	2	5.1	CC(C)C(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		11165283	123132	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	392	9	2	2	4.8	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		CHEMBL361206	123132	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	392	9	2	2	4.8	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		137655489	158975	0	None	7	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	245	4	2	3	1.5	COc1cnc2cccc(CCNC(N)=O)c2c1	10.1016/j.ejmech.2016.12.013
		CHEMBL4096197	158975	0	None	7	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	245	4	2	3	1.5	COc1cnc2cccc(CCNC(N)=O)c2c1	10.1016/j.ejmech.2016.12.013
		56681902	64452	0	None	-10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	554	21	2	6	5.4	CC(=O)NCCN(C)c1cccc(OCCCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
		CHEMBL1813323	64452	0	None	-10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	554	21	2	6	5.4	CC(=O)NCCN(C)c1cccc(OCCCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
		54584155	60756	0	None	2	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	366	8	1	5	2.8	COc1ccc2c(CN(C)Cc3ccccc3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		CHEMBL1760949	60756	0	None	2	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	366	8	1	5	2.8	COc1ccc2c(CN(C)Cc3ccccc3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		11501012	77242	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	340	5	1	3	3.9	COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCCC1)cn2C	10.1021/jm0512544
		CHEMBL207959	77242	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	340	5	1	3	3.9	COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCCC1)cn2C	10.1021/jm0512544
		16105170	189727	0	None	4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm800974d
		CHEMBL515696	189727	0	None	4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm800974d
		16105170	189727	0	None	4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1016/j.bmc.2009.04.068
		CHEMBL515696	189727	0	None	4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1016/j.bmc.2009.04.068
		16743288	92327	0	None	14	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	338	5	1	2	4.7	CCCC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1	10.1016/j.ejmech.2007.01.005
		CHEMBL243003	92327	0	None	14	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	338	5	1	2	4.7	CCCC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1	10.1016/j.ejmech.2007.01.005
		162649850	180138	0	None	7	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
		CHEMBL4748822	180138	0	None	7	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
		162656758	180922	0	None	5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
		CHEMBL4757920	180922	0	None	5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
		10637638	20601	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	295	5	1	2	3.4	COc1ccc2cccc3c2c1C(CCNC(=O)C1CC1)C3	10.1021/jm000922c
		CHEMBL130813	20601	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	295	5	1	2	3.4	COc1ccc2cccc3c2c1C(CCNC(=O)C1CC1)C3	10.1021/jm000922c
		16105170	189727	0	None	4	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to MT2 receptor (unknown origin)Binding affinity to MT2 receptor (unknown origin)	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm401343c
		CHEMBL515696	189727	0	None	4	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to MT2 receptor (unknown origin)Binding affinity to MT2 receptor (unknown origin)	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm401343c
		16105170	189727	0	None	4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm800974d
		CHEMBL515696	189727	0	None	4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm800974d
		16105170	189727	0	None	4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1016/j.bmc.2008.07.012
		CHEMBL515696	189727	0	None	4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1016/j.bmc.2008.07.012
		162647716	179887	0	None	3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
		CHEMBL4745789	179887	0	None	3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
		16094576	138132	6	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	253	5	1	1	3.1	CC(=O)NCC(Cc1ccccc1)c1ccccc1	10.1021/jm060850a
		CHEMBL376693	138132	6	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	253	5	1	1	3.1	CC(=O)NCC(Cc1ccccc1)c1ccccc1	10.1021/jm060850a
		45269183	196025	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	385	7	2	3	4.1	COc1ccc2[nH]c(CN(C)c3ccc(Cl)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
		CHEMBL560186	196025	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	385	7	2	3	4.1	COc1ccc2[nH]c(CN(C)c3ccc(Cl)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
		10704742	107261	0	None	-1	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1cccc2cc(CCNC(C)=O)[nH]c12	10.1021/jm001125h
		CHEMBL316952	107261	0	None	-1	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1cccc2cc(CCNC(C)=O)[nH]c12	10.1021/jm001125h
		44579261	186979	0	None	87	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.9	COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		CHEMBL490594	186979	0	None	87	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.9	COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		127038131	136651	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	363	9	1	3	4.4	CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
		CHEMBL3740052	136651	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	363	9	1	3	4.4	CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
		137655126	158626	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	260	4	1	4	2.1	COC(=O)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
		CHEMBL4092353	158626	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	260	4	1	4	2.1	COC(=O)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
		49865425	15960	0	None	-1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)N[C@@H](C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
		CHEMBL1223347	15960	0	None	-1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)N[C@@H](C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
		127038131	136651	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	363	9	1	3	4.4	CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
		CHEMBL3740052	136651	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	363	9	1	3	4.4	CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
		86273222	121323	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1	10.1021/acs.jmedchem.5b00245
		CHEMBL3580913	121323	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1	10.1021/acs.jmedchem.5b00245
		44424022	83472	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	718	23	4	8	6.9	COc1ccc2[nH]c(C(=O)OCCCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
		CHEMBL220091	83472	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	718	23	4	8	6.9	COc1ccc2[nH]c(C(=O)OCCCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
		145964105	164218	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	475	12	2	5	4.9	CC(=O)NCCN(C)c1cccc(OCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
		CHEMBL4211018	164218	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	475	12	2	5	4.9	CC(=O)NCCN(C)c1cccc(OCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
		122162	2387	75	None	18	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm980684+
		1363	2387	75	None	18	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm980684+
		CHEMBL286615	2387	75	None	18	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm980684+
		10664333	208183	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	332	4	1	2	4.3	CCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
		CHEMBL9838	208183	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	332	4	1	2	4.3	CCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
		11002150	107553	0	None	7	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	334	6	1	3	3.7	COc1cccc2c1cc(CCNC(=O)C1CC1)n2-c1ccccc1	10.1021/jm001125h
		CHEMBL318871	107553	0	None	7	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	334	6	1	3	3.7	COc1cccc2c1cc(CCNC(=O)C1CC1)n2-c1ccccc1	10.1021/jm001125h
		18007928	8665	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	485	12	2	4	5.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12	10.1016/j.bmc.2010.04.008
		CHEMBL1095504	8665	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	485	12	2	4	5.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12	10.1016/j.bmc.2010.04.008
		44429455	87748	0	None	2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	322	5	1	3	3.5	COc1cc(-c2ccccc2)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
		CHEMBL233740	87748	0	None	2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	322	5	1	3	3.5	COc1cc(-c2ccccc2)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
		11287002	15929	2	None	4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)N[C@@H](C)COc1ccccc1	10.1016/j.bmc.2010.06.100
		CHEMBL1223275	15929	2	None	4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)N[C@@H](C)COc1ccccc1	10.1016/j.bmc.2010.06.100
		3964826	15854	30	None	1	2	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1ccc(OCCNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
		CHEMBL1223054	15854	30	None	1	2	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1ccc(OCCNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
		127025170	137742	0	None	4	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
		CHEMBL3759180	137742	0	None	4	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
		162649247	180075	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	351	6	1	5	3.0	COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1	10.1016/j.ejmech.2020.112078
		CHEMBL4747996	180075	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	351	6	1	5	3.0	COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1	10.1016/j.ejmech.2020.112078
		46885230	8193	0	None	8	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	223	5	2	3	1.5	COc1ccc(O)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
		CHEMBL1092062	8193	0	None	8	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	223	5	2	3	1.5	COc1ccc(O)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
		122162	2387	75	None	18	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1016/j.ejmech.2007.01.005
		1363	2387	75	None	18	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1016/j.ejmech.2007.01.005
		CHEMBL286615	2387	75	None	18	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1016/j.ejmech.2007.01.005
		137656715	159547	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	308	5	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
		CHEMBL4102517	159547	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	308	5	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
		12985496	182331	0	None	31	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	389	7	2	3	4.5	COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1	10.1016/j.bmc.2008.08.052
		CHEMBL478438	182331	0	None	31	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	389	7	2	3	4.5	COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1	10.1016/j.bmc.2008.08.052
		49865317	15894	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(S[C@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223191	15894	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(S[C@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
		49865374	15931	0	None	7	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC[C@@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223277	15931	0	None	7	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC[C@@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
		56653120	110869	0	None	-12	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	336	8	2	2	3.9	CC(=O)NCCc1c[nH]c2ccc(OCCCc3ccccc3)cc12	10.1021/jm401343c
		CHEMBL3260985	110869	0	None	-12	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	336	8	2	2	3.9	CC(=O)NCCc1c[nH]c2ccc(OCCCc3ccccc3)cc12	10.1021/jm401343c
		86273470	121322	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	256	4	1	3	3.3	COc1ccc2[nH]cc(CCc3ncc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
		CHEMBL3580912	121322	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	256	4	1	3	3.3	COc1ccc2[nH]cc(CCc3ncc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
		20590653	123275	0	None	-5	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	389	9	1	2	5.0	O=C(NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1	10.1016/j.bmcl.2005.01.015
		CHEMBL361410	123275	0	None	-5	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	389	9	1	2	5.0	O=C(NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1	10.1016/j.bmcl.2005.01.015
		54581170	60763	0	None	3	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	359	4	1	4	1.8	COc1ccc2c(I)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		CHEMBL1760956	60763	0	None	3	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	359	4	1	4	1.8	COc1ccc2c(I)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		127040355	137913	0	None	13	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	410	5	1	4	5.5	COc1ccc2oc(-c3cc4ccccc4c4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		CHEMBL3763537	137913	0	None	13	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	410	5	1	4	5.5	COc1ccc2oc(-c3cc4ccccc4c4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		127040022	137951	0	None	6	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	410	5	1	4	5.5	COc1ccc2oc(-c3c4ccccc4cc4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		CHEMBL3764063	137951	0	None	6	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	410	5	1	4	5.5	COc1ccc2oc(-c3c4ccccc4cc4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		10641756	98278	0	None	57	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	352	3	1	2	4.6	CC(=O)NCCc1c2n(c3ccc(Cl)cc13)CCCc1ccccc1-2	10.1021/jm980684+
		CHEMBL274630	98278	0	None	57	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	352	3	1	2	4.6	CC(=O)NCCc1c2n(c3ccc(Cl)cc13)CCCc1ccccc1-2	10.1021/jm980684+
		16094587	83262	3	None	72	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	297	7	1	2	3.7	CCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
		CHEMBL218774	83262	3	None	72	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	297	7	1	2	3.7	CCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
		49865322	15899	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NCC(C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223196	15899	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NCC(C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
		162674581	183312	0	None	51	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	268	3	1	4	2.7	COc1ccc2cccc(/C=C/c3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
		CHEMBL4797226	183312	0	None	51	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	268	3	1	4	2.7	COc1ccc2cccc(/C=C/c3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
		11351216	62404	0	None	4	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	441	6	1	3	5.4	O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
		CHEMBL1779807	62404	0	None	4	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	441	6	1	3	5.4	O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
		22718576	114605	0	None	4	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	1	3	2.2	CC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL333810	114605	0	None	4	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	1	3	2.2	CC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
		3956219	101547	11	None	2	2	Human	8.3	pKi	=	8.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1cc2c(CCNC(C)=O)c[nH]c2cc1[N+](=O)[O-]	10.1021/jm011053+
		CHEMBL298335	101547	11	None	2	2	Human	8.3	pKi	=	8.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1cc2c(CCNC(C)=O)c[nH]c2cc1[N+](=O)[O-]	10.1021/jm011053+
		16094595	83261	4	None	407	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.4	COc1cccc(C(CCNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
		CHEMBL218773	83261	4	None	407	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.4	COc1cccc(C(CCNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
		23658145	157463	1	None	33	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
		CHEMBL4079214	157463	1	None	33	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
		1347	162	56	None	1	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10.1016/j.ejmech.2019.111847
		1864	162	56	None	1	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10.1016/j.ejmech.2019.111847
		CHEMBL127421	162	56	None	1	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10.1016/j.ejmech.2019.111847
		44264849	205372	0	None	19	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	298	5	1	3	4.1	COc1cccc(N(C)c2ccc(NC(=O)C(C)C)cc2)c1	10.1016/j.bmcl.2003.11.030
		CHEMBL7990	205372	0	None	19	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	298	5	1	3	4.1	COc1cccc(N(C)c2ccc(NC(=O)C(C)C)cc2)c1	10.1016/j.bmcl.2003.11.030
		10808489	207775	0	None	42	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	360	6	1	3	4.1	CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1	10.1021/jm980684+
		CHEMBL9600	207775	0	None	42	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	360	6	1	3	4.1	CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1	10.1021/jm980684+
		90666303	109380	0	None	31	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	361	6	2	3	3.9	COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
		CHEMBL3219324	109380	0	None	31	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	361	6	2	3	3.9	COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
		44358218	27516	0	None	3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	289	4	2	3	1.9	CCCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		CHEMBL136895	27516	0	None	3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	289	4	2	3	1.9	CCCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		15453819	204983	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	287	6	1	4	3.1	COCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL7659	204983	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	287	6	1	4	3.1	COCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		49865267	15876	2	None	7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1ccccc1SCCNC(C)=O	10.1016/j.bmc.2010.06.100
		CHEMBL1223127	15876	2	None	7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1ccccc1SCCNC(C)=O	10.1016/j.bmc.2010.06.100
		7778	814	0	None	-97	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
		9957516	814	0	None	-97	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
		CHEMBL1094546	814	0	None	-97	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
		49865148	15831	2	None	2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1ccccc1OC(C)CNC(C)=O	10.1016/j.bmc.2010.06.100
		CHEMBL1222984	15831	2	None	2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1ccccc1OC(C)CNC(C)=O	10.1016/j.bmc.2010.06.100
		44349269	16588	1	None	3	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	289	6	2	3	3.2	CCNC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL123972	16588	1	None	3	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	289	6	2	3	3.2	CCNC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
		44394456	66116	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	378	10	2	2	5.3	CCNC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		CHEMBL183962	66116	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	378	10	2	2	5.3	CCNC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		23658143	156377	1	None	6	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
		CHEMBL4066279	156377	1	None	6	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
		24750195	88554	0	None	24	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	298	6	0	3	3.3	COc1cccc(N(CCN(C)C(C)=O)c2ccccc2)c1	10.1021/jm700957j
		CHEMBL235334	88554	0	None	24	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	298	6	0	3	3.3	COc1cccc(N(CCN(C)C(C)=O)c2ccccc2)c1	10.1021/jm700957j
		11791741	208110	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	344	4	1	2	4.3	O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CC1	10.1021/jm980684+
		CHEMBL9791	208110	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	344	4	1	2	4.3	O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CC1	10.1021/jm980684+
		16094592	83285	1	None	6	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.4	CC(=O)NC/C(=C/c1ccccc1)c1ccccc1	10.1021/jm060850a
		CHEMBL218926	83285	1	None	6	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.4	CC(=O)NC/C(=C/c1ccccc1)c1ccccc1	10.1021/jm060850a
		145966403	164208	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	497	13	2	6	4.9	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1	10.1021/acs.jmedchem.8b00893
		CHEMBL4210884	164208	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	497	13	2	6	4.9	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1	10.1021/acs.jmedchem.8b00893
		122178510	121330	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	275	4	2	4	3.0	COc1ccc2[nH]cc(CCc3n[nH]c(=S)o3)c2c1	10.1021/acs.jmedchem.5b00245
		CHEMBL3580921	121330	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	275	4	2	4	3.0	COc1ccc2[nH]cc(CCc3n[nH]c(=S)o3)c2c1	10.1021/acs.jmedchem.5b00245
		162670470	182909	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	343	9	1	5	3.7	CCCCCCn1nc(CCc2c[nH]c3ccc(OC)cc23)oc1=O	10.1016/j.ejmech.2020.112090
		CHEMBL4792353	182909	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	343	9	1	5	3.7	CCCCCCn1nc(CCc2c[nH]c3ccc(OC)cc23)oc1=O	10.1016/j.ejmech.2020.112090
		86272988	121329	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	261	3	2	4	2.8	COc1ccc2[nH]cc(Cc3n[nH]c(=S)o3)c2c1	10.1021/acs.jmedchem.5b00245
		CHEMBL3580920	121329	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	261	3	2	4	2.8	COc1ccc2[nH]cc(Cc3n[nH]c(=S)o3)c2c1	10.1021/acs.jmedchem.5b00245
		11310062	15928	2	None	1	2	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)N[C@H](C)COc1ccccc1	10.1016/j.bmc.2010.06.100
		CHEMBL1223274	15928	2	None	1	2	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)N[C@H](C)COc1ccccc1	10.1016/j.bmc.2010.06.100
		44394416	66238	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	389	9	1	2	5.9	CC(C)C(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		CHEMBL184562	66238	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	389	9	1	2	5.9	CC(C)C(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		12436516	15856	6	None	2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	179	4	1	2	1.2	CC(=O)NCCOc1ccccc1	10.1016/j.bmc.2010.06.100
		CHEMBL1223056	15856	6	None	2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	179	4	1	2	1.2	CC(=O)NCCOc1ccccc1	10.1016/j.bmc.2010.06.100
		54586060	60758	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	332	6	1	6	1.0	COc1ccc2c(CN3CCOCC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		CHEMBL1760951	60758	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	332	6	1	6	1.0	COc1ccc2c(CN3CCOCC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		137657824	159797	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
		CHEMBL4105511	159797	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
		86272986	121331	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	258	3	2	4	1.2	COc1ccc2[nH]cc(Cc3n[nH]c(=O)n3C)c2c1	10.1021/acs.jmedchem.5b00245
		CHEMBL3580922	121331	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	258	3	2	4	1.2	COc1ccc2[nH]cc(Cc3n[nH]c(=O)n3C)c2c1	10.1021/acs.jmedchem.5b00245
		22718548	16501	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	322	6	1	3	4.2	CC(C)C(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL123612	16501	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	322	6	1	3	4.2	CC(C)C(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		11543959	77124	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	300	6	2	2	3.5	CCCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1	10.1021/jm0512544
		CHEMBL207676	77124	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	300	6	2	2	3.5	CCCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1	10.1021/jm0512544
		44424026	142336	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	546	17	4	4	5.8	COc1ccc2[nH]cc(CCNC(=O)CCCCCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1016/j.bmc.2007.03.080
		CHEMBL388591	142336	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	546	17	4	4	5.8	COc1ccc2[nH]cc(CCNC(=O)CCCCCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1016/j.bmc.2007.03.080
		11666721	64990	0	None	18	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	1	4	2.7	CNC(=O)CCc1c(-c2ccccc2)nc2ccc(OC)cn12	10.1016/j.ejmech.2011.06.030
		CHEMBL1823016	64990	0	None	18	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	1	4	2.7	CNC(=O)CCc1c(-c2ccccc2)nc2ccc(OC)cn12	10.1016/j.ejmech.2011.06.030
		127039218	137896	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	234	4	1	4	1.5	COc1cc2c(CCNC(C)=O)coc2cn1	10.1016/j.ejmech.2016.01.008
		CHEMBL3763247	137896	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	234	4	1	4	1.5	COc1cc2c(CCNC(C)=O)coc2cn1	10.1016/j.ejmech.2016.01.008
		46845151	8666	0	None	-38	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	499	12	2	4	6.1	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12	10.1016/j.bmc.2010.04.008
		CHEMBL1095505	8666	0	None	-38	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	499	12	2	4	6.1	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12	10.1016/j.bmc.2010.04.008
		137656978	159763	0	None	147	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	294	4	1	2	3.1	CCC(=O)NC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
		CHEMBL4105125	159763	0	None	147	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	294	4	1	2	3.1	CCC(=O)NC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
		137661786	159115	0	None	4	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	262	5	1	3	1.9	COc1cnc2cccc(CCNC(=O)CF)c2c1	10.1016/j.ejmech.2016.12.013
		CHEMBL4097693	159115	0	None	4	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	262	5	1	3	1.9	COc1cnc2cccc(CCNC(=O)CF)c2c1	10.1016/j.ejmech.2016.12.013
		44394535	67013	0	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	390	8	1	3	5.1	CCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
		CHEMBL186977	67013	0	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	390	8	1	3	5.1	CCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
		16094580	81558	4	None	11	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.0	COc1ccc(Cc2ccccc2)c(CCNC(C)=O)c1	10.1021/jm060850a
		CHEMBL216158	81558	4	None	11	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.0	COc1ccc(Cc2ccccc2)c(CCNC(C)=O)c1	10.1021/jm060850a
		49865324	15901	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NC[C@H](C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223198	15901	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NC[C@H](C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
		24955342	63790	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.6	CC(=O)NCCc1c(-c2ccccc2)nc2ccc3c(n12)CCO3	10.1021/jm200385u
		CHEMBL1802020	63790	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.6	CC(=O)NCCc1c(-c2ccccc2)nc2ccc3c(n12)CCO3	10.1021/jm200385u
		23725513	125848	0	None	3	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
		CHEMBL3648357	125848	0	None	3	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
		10760155	98419	0	None	43	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	4	1	3	3.9	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1	10.1021/jm980684+
		CHEMBL275529	98419	0	None	43	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	4	1	3	3.9	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1	10.1021/jm980684+
		145976009	163532	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	541	15	3	4	7.0	CC(=O)NCCc1c[nH]c2ccc(OCCCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12	10.1021/acs.jmedchem.8b00893
		CHEMBL4202816	163532	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	541	15	3	4	7.0	CC(=O)NCCc1c[nH]c2ccc(OCCCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12	10.1021/acs.jmedchem.8b00893
		44358312	29822	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	274	3	1	3	2.0	CC(C)C(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		CHEMBL138744	29822	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	274	3	1	3	2.0	CC(C)C(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		10829695	119205	0	None	21	2	Human	8.2	pKi	=	8.2	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B	ChEMBL	322	6	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1	10.1021/jm020982d
		CHEMBL34327	119205	0	None	21	2	Human	8.2	pKi	=	8.2	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B	ChEMBL	322	6	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1	10.1021/jm020982d
		10829695	119205	0	None	21	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	322	6	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1	10.1021/jm048956y
		CHEMBL34327	119205	0	None	21	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	322	6	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1	10.1021/jm048956y
		10596576	4173	0	None	39	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	390	7	1	3	5.1	CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)CCCc1ccccc1-2	10.1021/jm980684+
		CHEMBL10007	4173	0	None	39	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	390	7	1	3	5.1	CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)CCCc1ccccc1-2	10.1021/jm980684+
		71540395	86416	0	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	256	3	2	2	2.7	CNC(=O)N/C=C/c1c(OC)ccc2ccccc12	10.1016/j.bmcl.2012.11.069
		CHEMBL2314258	86416	0	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	256	3	2	2	2.7	CNC(=O)N/C=C/c1c(OC)ccc2ccccc12	10.1016/j.bmcl.2012.11.069
		10163052	8521	0	None	-72	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	483	12	2	4	5.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12	10.1016/j.bmc.2010.04.008
		CHEMBL1094212	8521	0	None	-72	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	483	12	2	4	5.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12	10.1016/j.bmc.2010.04.008
		44317725	205671	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	329	9	1	3	4.1	CCCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
		CHEMBL82135	205671	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	329	9	1	3	4.1	CCCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
		49865318	15895	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(S[C@@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223192	15895	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(S[C@@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
		18360631	8715	0	None	-26	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	516	13	2	4	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12	10.1016/j.bmc.2010.04.008
		CHEMBL1095831	8715	0	None	-26	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	516	13	2	4	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12	10.1016/j.bmc.2010.04.008
		9881917	97041	0	None	44	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	271	5	1	3	3.8	CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL266970	97041	0	None	44	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	271	5	1	3	3.8	CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		71540275	86409	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	225	2	1	1	2.8	CC(=O)N[C@@H]1C[C@H]1c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
		CHEMBL2314250	86409	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	225	2	1	1	2.8	CC(=O)N[C@@H]1C[C@H]1c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
		44241665	195700	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	329	6	1	4	2.6	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
		CHEMBL556908	195700	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	329	6	1	4	2.6	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
		168288029	191621	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	471	9	1	9	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
		CHEMBL5195595	191621	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	471	9	1	9	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
		10384120	124391	0	None	-7	2	Human	7.2	pKi	=	7.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	363	10	1	2	5.5	CCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		CHEMBL363936	124391	0	None	-7	2	Human	7.2	pKi	=	7.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	363	10	1	2	5.5	CCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		25022442	189559	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1021/jm800974d
		CHEMBL514413	189559	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1021/jm800974d
		145977894	163849	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	372	11	2	5	3.2	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(O)c2)c1	10.1021/acs.jmedchem.8b00893
		CHEMBL4206516	163849	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	372	11	2	5	3.2	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(O)c2)c1	10.1021/acs.jmedchem.8b00893
		11314110	70738	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	350	6	1	3	4.3	CCC(=O)NCc1cc2c(OC)cccc2n1Cc1c(C)cccc1C	10.1021/jm048956y
		CHEMBL195074	70738	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	350	6	1	3	4.3	CCC(=O)NCc1cc2c(OC)cccc2n1Cc1c(C)cccc1C	10.1021/jm048956y
		44349294	18553	1	None	5	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	323	6	2	3	3.7	CCNC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL127576	18553	1	None	5	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	323	6	2	3	3.7	CCNC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		44429453	87541	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	322	6	2	2	3.9	CCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		CHEMBL233517	87541	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	322	6	2	2	3.9	CCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		11500596	138679	0	None	7	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	312	5	2	2	3.5	COc1ccc2[nH]cc(C3(CNC(=O)C4CCC4)CCC3)c2c1	10.1021/jm0512544
		CHEMBL377809	138679	0	None	7	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	312	5	2	2	3.5	COc1ccc2[nH]cc(C3(CNC(=O)C4CCC4)CCC3)c2c1	10.1021/jm0512544
		44424018	85358	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	620	16	4	8	4.2	COc1ccc2[nH]c(C(=O)OCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
		CHEMBL226162	85358	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	620	16	4	8	4.2	COc1ccc2[nH]c(C(=O)OCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
		45268310	196563	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	419	7	2	3	4.5	COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
		CHEMBL563847	196563	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	419	7	2	3	4.5	COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
		10807560	208147	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	346	5	1	2	4.7	CCCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
		CHEMBL9815	208147	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	346	5	1	2	4.7	CCCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
		45268310	196563	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	419	7	2	3	4.5	COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
		CHEMBL563847	196563	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	419	7	2	3	4.5	COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
		44264689	205051	1	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	282	5	2	3	3.8	COc1cccc(Nc2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
		CHEMBL7713	205051	1	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	282	5	2	3	3.8	COc1cccc(Nc2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
		25022442	189559	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1016/j.bmc.2009.04.068
		CHEMBL514413	189559	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1016/j.bmc.2009.04.068
		10563168	119692	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	258	4	2	2	2.6	COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12	10.1021/jm001125h
		CHEMBL34729	119692	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	258	4	2	2	2.6	COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12	10.1021/jm001125h
		49865424	15959	0	None	1	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)N[C@H](C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
		CHEMBL1223346	15959	0	None	1	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)N[C@H](C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
		25022442	189559	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1021/jm800974d
		CHEMBL514413	189559	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1021/jm800974d
		44424019	85359	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	648	18	4	8	5.0	COc1ccc2[nH]c(C(=O)OCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
		CHEMBL226163	85359	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	648	18	4	8	5.0	COc1ccc2[nH]c(C(=O)OCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
		25022442	189559	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1016/j.bmc.2008.07.012
		CHEMBL514413	189559	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1016/j.bmc.2008.07.012
		11536746	139451	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	300	4	1	3	3.1	COc1ccc2c(c1)c(C1(CNC(C)=O)CCCC1)cn2C	10.1021/jm0512544
		CHEMBL379403	139451	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	300	4	1	3	3.1	COc1ccc2c(c1)c(C1(CNC(C)=O)CCCC1)cn2C	10.1021/jm0512544
		45267465	194767	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	365	8	2	3	3.5	COc1ccc2[nH]c(CN(C)Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
		CHEMBL538129	194767	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	365	8	2	3	3.5	COc1ccc2[nH]c(CN(C)Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
		16094579	80842	5	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	267	6	1	1	3.3	CCC(=O)NCCc1cccc(Cc2ccccc2)c1	10.1021/jm060850a
		CHEMBL215252	80842	5	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells	ChEMBL	267	6	1	1	3.3	CCC(=O)NCCc1cccc(Cc2ccccc2)c1	10.1021/jm060850a
		49865205	15852	0	None	4	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(S[C@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223052	15852	0	None	4	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(S[C@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
		4207624	15855	37	None	5	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1ccccc1OCCNC(C)=O	10.1016/j.bmc.2010.06.100
		CHEMBL1223055	15855	37	None	5	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1ccccc1OCCNC(C)=O	10.1016/j.bmc.2010.06.100
		49865320	15897	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NC[C@@H](C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223194	15897	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NC[C@@H](C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
		44436051	151363	6	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1cccc(OCCNC(C)=O)c1	10.1016/j.bmc.2010.06.100
		CHEMBL396132	151363	6	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1cccc(OCCNC(C)=O)c1	10.1016/j.bmc.2010.06.100
		44429456	87929	0	None	8	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	336	6	1	3	3.9	CCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		CHEMBL233945	87929	0	None	8	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	336	6	1	3	3.9	CCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		49865423	15958	2	None	4	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)NC(C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
		CHEMBL1223345	15958	2	None	4	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)NC(C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
		122178508	121326	0	None	8	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	243	4	1	4	2.3	COc1ccc2[nH]cc(CCc3nnco3)c2c1	10.1021/acs.jmedchem.5b00245
		CHEMBL3580917	121326	0	None	8	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins	ChEMBL	243	4	1	4	2.3	COc1ccc2[nH]cc(CCc3nnco3)c2c1	10.1021/acs.jmedchem.5b00245
		162672373	183087	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	298	4	1	5	2.7	COc1cc2cccc(/C=C/c3n[nH]c(=O)o3)c2cc1OC	10.1016/j.ejmech.2020.112090
		CHEMBL4794450	183087	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	298	4	1	5	2.7	COc1cc2cccc(/C=C/c3n[nH]c(=O)o3)c2cc1OC	10.1016/j.ejmech.2020.112090
		46884554	8298	0	None	128	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	313	8	1	3	3.3	COc1cc(CCCNC(C)=O)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
		CHEMBL1092647	8298	0	None	128	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	313	8	1	3	3.3	COc1cc(CCCNC(C)=O)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
		127027022	137809	0	None	19	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	314	4	2	3	3.6	CCNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
		CHEMBL3759677	137809	0	None	19	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	314	4	2	3	3.6	CCNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
		10104923	101500	2	None	12	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	221	6	1	2	2.2	CCC(=O)NCCCc1cccc(OC)c1	10.1016/j.bmcl.2010.02.084
		CHEMBL297947	101500	2	None	12	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	221	6	1	2	2.2	CCC(=O)NCCCc1cccc(OC)c1	10.1016/j.bmcl.2010.02.084
		25209998	189742	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	393	7	2	4	3.4	COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1021/jm800974d
		CHEMBL515856	189742	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	393	7	2	4	3.4	COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1021/jm800974d
		49865206	15853	1	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(S[C@@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223053	15853	1	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(S[C@@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
		25209998	189742	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	393	7	2	4	3.4	COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1021/jm800974d
		CHEMBL515856	189742	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	393	7	2	4	3.4	COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1021/jm800974d
		44264843	204847	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	300	5	1	4	4.0	CCOC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		CHEMBL7556	204847	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	300	5	1	4	4.0	CCOC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
		44394508	66145	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	404	9	1	3	5.5	CCCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
		CHEMBL184144	66145	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	404	9	1	3	5.5	CCCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
		18466111	19845	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
		CHEMBL130214	19845	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
		24750070	153553	4	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	208	5	2	3	1.2	COc1cccc(NCCNC(C)=O)c1	10.1021/jm700957j
		CHEMBL398017	153553	4	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	208	5	2	3	1.2	COc1cccc(NCCNC(C)=O)c1	10.1021/jm700957j
		11688043	77995	0	None	28	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	300	6	1	3	3.1	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1	10.1021/jm0512544
		CHEMBL209712	77995	0	None	28	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	300	6	1	3	3.1	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1	10.1021/jm0512544
		44579296	186794	0	None	5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	376	6	2	3	4.2	COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		CHEMBL489170	186794	0	None	5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	376	6	2	3	4.2	COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
		10639585	114463	0	None	83	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm001125h
		CHEMBL33346	114463	0	None	83	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm001125h
		44349362	16574	0	None	5	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	286	7	1	3	3.2	CCCc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
		CHEMBL123899	16574	0	None	5	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	286	7	1	3	3.2	CCCc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
		44424020	85362	0	None	7	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	676	20	4	8	5.8	COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
		CHEMBL226171	85362	0	None	7	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	676	20	4	8	5.8	COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
		10518884	112554	0	None	11	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	308	5	1	3	3.3	COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1	10.1021/jm001125h
		CHEMBL329979	112554	0	None	11	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	308	5	1	3	3.3	COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1	10.1021/jm001125h
		127041168	136604	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	388	10	2	3	3.9	O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F	10.1039/C5MD00190K
		CHEMBL3739674	136604	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	388	10	2	3	3.9	O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F	10.1039/C5MD00190K
		45268303	196745	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	301	4	1	4	1.8	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCN(C)C1	10.1016/j.bmc.2009.04.068
		CHEMBL565176	196745	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	301	4	1	4	1.8	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCN(C)C1	10.1016/j.bmc.2009.04.068
		127041168	136604	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	388	10	2	3	3.9	O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F	10.1039/C5MD00190K
		CHEMBL3739674	136604	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	388	10	2	3	3.9	O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F	10.1039/C5MD00190K
		25022429	188149	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	393	7	3	4	2.8	COc1ccc2[nH]c(CN3c4ccccc4C[C@H]3CO)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.07.012
		CHEMBL498493	188149	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells	ChEMBL	393	7	3	4	2.8	COc1ccc2[nH]c(CN3c4ccccc4C[C@H]3CO)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.07.012
		16750566	142032	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	662	19	4	8	5.4	COc1ccc2[nH]c(C(=O)OCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
		CHEMBL387655	142032	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	662	19	4	8	5.4	COc1ccc2[nH]c(C(=O)OCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
		16743124	92209	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	282	5	1	2	3.0	O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CC1	10.1016/j.ejmech.2007.01.005
		CHEMBL242573	92209	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	282	5	1	2	3.0	O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CC1	10.1016/j.ejmech.2007.01.005
		11616210	139458	0	None	6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	286	4	1	3	2.7	COc1ccc2c(c1)c(C1(CNC(C)=O)CCC1)cn2C	10.1021/jm0512544
		CHEMBL379413	139458	0	None	6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	286	4	1	3	2.7	COc1ccc2c(c1)c(C1(CNC(C)=O)CCC1)cn2C	10.1021/jm0512544
		46885287	8169	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	341	10	1	3	3.8	COc1ccc(OCCCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
		CHEMBL1091896	8169	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	341	10	1	3	3.8	COc1ccc(OCCCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
		1355	3438	5	None	-70	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
		9806449	3438	5	None	-70	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
		CHEMBL14453	3438	5	None	-70	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
		1355	3438	5	None	-70	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
		9806449	3438	5	None	-70	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
		CHEMBL14453	3438	5	None	-70	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
		44424025	85174	0	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	504	14	4	4	4.6	COc1ccc2[nH]cc(CCNC(=O)CCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1016/j.bmc.2007.03.080
		CHEMBL225302	85174	0	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells	ChEMBL	504	14	4	4	4.6	COc1ccc2[nH]cc(CCNC(=O)CCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1016/j.bmc.2007.03.080
		137633839	156610	0	None	7	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
		CHEMBL4068922	156610	0	None	7	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
		10526493	205294	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	427	8	1	3	3.7	CCC(=O)NCCc1c(OCCI)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
		CHEMBL79224	205294	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	427	8	1	3	3.7	CCC(=O)NCCc1c(OCCI)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
		1355	3438	5	None	-70	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to MT2 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
		9806449	3438	5	None	-70	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to MT2 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
		CHEMBL14453	3438	5	None	-70	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to MT2 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
		1355	3438	5	None	-70	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 mins	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
		9806449	3438	5	None	-70	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 mins	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
		CHEMBL14453	3438	5	None	-70	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 mins	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
		54582194	60757	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	330	6	1	5	2.2	COc1ccc2c(CN3CCCCC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		CHEMBL1760950	60757	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	330	6	1	5	2.2	COc1ccc2c(CN3CCCCC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		54583161	60760	0	None	1	2	Human	5.1	pKi	=	5.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	452	8	1	6	3.4	COc1ccc2c(CN3CCC(C(=O)c4ccc(F)cc4)CC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		CHEMBL1760953	60760	0	None	1	2	Human	5.1	pKi	=	5.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	452	8	1	6	3.4	COc1ccc2c(CN3CCC(C(=O)c4ccc(F)cc4)CC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		10849065	137	8	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		1345	137	8	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		CHEMBL126809	137	8	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
		11109646	207072	0	None	7	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	309	5	2	3	3.4	CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(O)cc12	10.1021/jm0005252
		CHEMBL91813	207072	0	None	7	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	309	5	2	3	3.4	CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(O)cc12	10.1021/jm0005252
		54770909	64992	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	339	6	2	5	2.0	COc1ccc2nc(-c3ccccc3)c(CC(CO)NC(C)=O)n2c1	10.1016/j.ejmech.2011.06.030
		CHEMBL1823018	64992	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	339	6	2	5	2.0	COc1ccc2nc(-c3ccccc3)c(CC(CO)NC(C)=O)n2c1	10.1016/j.ejmech.2011.06.030
		162658247	181018	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2cnnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
		CHEMBL4759137	181018	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2cnnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
		12071674	123943	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	351	9	1	2	4.5	CC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		CHEMBL362849	123943	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	351	9	1	2	4.5	CC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		25209861	175219	0	None	5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	405	8	2	3	4.6	CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12	10.1021/jm800974d
		CHEMBL457138	175219	0	None	5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	405	8	2	3	4.6	CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12	10.1021/jm800974d
		11702296	64991	6	None	3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	1	4	2.7	COc1ccc2nc(-c3ccccc3)c(CCNC(C)=O)n2c1	10.1016/j.ejmech.2011.06.030
		CHEMBL1823017	64991	6	None	3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	1	4	2.7	COc1ccc2nc(-c3ccccc3)c(CCNC(C)=O)n2c1	10.1016/j.ejmech.2011.06.030
		127041169	136848	0	None	-6	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	570	14	2	4	5.7	O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
		CHEMBL3741890	136848	0	None	-6	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	570	14	2	4	5.7	O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
		127041169	136848	0	None	-6	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	570	14	2	4	5.7	O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
		CHEMBL3741890	136848	0	None	-6	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	570	14	2	4	5.7	O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
		25209861	175219	0	None	5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	405	8	2	3	4.6	CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12	10.1021/jm800974d
		CHEMBL457138	175219	0	None	5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	405	8	2	3	4.6	CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12	10.1021/jm800974d
		10969292	207832	0	None	7	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	321	6	1	2	4.3	CCc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		CHEMBL96333	207832	0	None	7	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	321	6	1	2	4.3	CCc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		44579164	182130	0	None	14	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	406	7	2	4	4.8	CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
		CHEMBL478218	182130	0	None	14	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	406	7	2	4	4.8	CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
		46888520	8643	0	None	-10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	538	15	2	4	6.1	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
		CHEMBL1095195	8643	0	None	-10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	538	15	2	4	6.1	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
		10428383	3913	5	None	151	2	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at human MT2 receptorAntagonist activity at human MT2 receptor	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm401343c
		7783	3913	5	None	151	2	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at human MT2 receptorAntagonist activity at human MT2 receptor	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm401343c
		CHEMBL33185	3913	5	None	151	2	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at human MT2 receptorAntagonist activity at human MT2 receptor	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm401343c
		10428383	3913	5	None	151	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm001125h
		7783	3913	5	None	151	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm001125h
		CHEMBL33185	3913	5	None	151	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm001125h
		10428383	3913	5	None	151	2	Human	8.1	pKi	=	8.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm048956y
		7783	3913	5	None	151	2	Human	8.1	pKi	=	8.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm048956y
		CHEMBL33185	3913	5	None	151	2	Human	8.1	pKi	=	8.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm048956y
		127038132	136814	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	361	9	1	2	4.9	CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12	10.1039/C5MD00190K
		CHEMBL3741561	136814	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	361	9	1	2	4.9	CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12	10.1039/C5MD00190K
		90666304	109381	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	401	7	2	3	4.6	COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1039/C1MD00149C
		CHEMBL3219325	109381	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	401	7	2	3	4.6	COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1039/C1MD00149C
		10656443	208375	2	None	1	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	218	3	2	2	1.8	COc1cccc2[nH]c(CNC(C)=O)cc12	10.1021/jm001125h
		CHEMBL99534	208375	2	None	1	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	218	3	2	2	1.8	COc1cccc2[nH]c(CNC(C)=O)cc12	10.1021/jm001125h
		56678563	64449	0	None	-14	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	484	16	2	6	3.5	CC(=O)NCCN(C)c1cccc(OCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
		CHEMBL1813320	64449	0	None	-14	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	484	16	2	6	3.5	CC(=O)NCCN(C)c1cccc(OCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
		18522267	66325	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	377	11	1	2	5.8	CCCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		CHEMBL184990	66325	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	377	11	1	2	5.8	CCCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		10956792	101811	7	None	1	2	Human	6.1	pKi	=	6.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1ccc2[nH]cc(CCNC(C)=O)c2c1[N+](=O)[O-]	10.1021/jm011053+
		CHEMBL300195	101811	7	None	1	2	Human	6.1	pKi	=	6.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1ccc2[nH]cc(CCNC(C)=O)c2c1[N+](=O)[O-]	10.1021/jm011053+
		10022490	67057	0	None	-22	2	Human	7.1	pKi	=	7.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	377	10	1	2	5.7	CC(C)C(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		CHEMBL187186	67057	0	None	-22	2	Human	7.1	pKi	=	7.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	377	10	1	2	5.7	CC(C)C(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		44264692	205233	1	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	284	5	2	3	4.0	COc1cccc(Nc2ccc(NC(=O)C(C)C)cc2)c1	10.1016/j.bmcl.2003.11.030
		CHEMBL7874	205233	1	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B	ChEMBL	284	5	2	3	4.0	COc1cccc(Nc2ccc(NC(=O)C(C)C)cc2)c1	10.1016/j.bmcl.2003.11.030
		46888491	8671	0	None	-20	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	501	13	3	4	4.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
		CHEMBL1095522	8671	0	None	-20	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	501	13	3	4	4.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
		44358087	116413	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	274	3	1	3	2.0	CC(C)C(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		CHEMBL336024	116413	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells	ChEMBL	274	3	1	3	2.0	CC(C)C(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
		10620323	208340	0	None	34	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	388	6	1	3	4.7	CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
		CHEMBL9935	208340	0	None	34	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	388	6	1	3	4.7	CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
		11595087	76667	0	None	6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	328	6	1	3	3.9	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1	10.1021/jm0512544
		CHEMBL206419	76667	0	None	6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	328	6	1	3	3.9	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1	10.1021/jm0512544
		11277044	126602	1	None	6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	263	2	1	1	3.3	CC(=O)NCC1=Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
		CHEMBL365249	126602	1	None	6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	263	2	1	1	3.3	CC(=O)NCC1=Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
		45269177	194865	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	299	5	1	3	2.5	CCCC(=O)NCCc1c2n(c3ccccc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
		CHEMBL540182	194865	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	299	5	1	3	2.5	CCCC(=O)NCCc1c2n(c3ccccc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
		44429457	169351	0	None	6	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	350	7	1	3	4.3	CCCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		CHEMBL441916	169351	0	None	6	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	350	7	1	3	4.3	CCCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		71540390	86418	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	235	4	1	3	1.7	COc1ccc(OC)c([C@@H]2C[C@H]2NC(C)=O)c1	10.1016/j.bmcl.2012.11.069
		CHEMBL2314263	86418	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	235	4	1	3	1.7	COc1ccc(OC)c([C@@H]2C[C@H]2NC(C)=O)c1	10.1016/j.bmcl.2012.11.069
		56653479	110870	0	None	-10	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
		CHEMBL3260986	110870	0	None	-10	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
		56653479	110870	0	None	-10	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1021/jm401343c
		CHEMBL3260986	110870	0	None	-10	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1021/jm401343c
		56653479	110870	0	None	-10	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
		CHEMBL3260986	110870	0	None	-10	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
		44429454	149215	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	336	7	2	2	4.3	CCCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		CHEMBL394408	149215	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	336	7	2	2	4.3	CCCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
		22718555	16589	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	6	1	3	3.7	CC(C)C(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL123973	16589	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	6	1	3	3.7	CC(C)C(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
		22718530	17947	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	294	5	1	3	3.6	CC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		CHEMBL126005	17947	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand	ChEMBL	294	5	1	3	3.6	CC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
		11219713	125843	0	None	4	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	279	3	1	1	3.4	CC(=O)NCCC1Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
		CHEMBL364835	125843	0	None	4	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells	ChEMBL	279	3	1	1	3.4	CC(=O)NCCC1Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
		45268318	196326	0	None	6	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	315	4	1	4	2.2	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCN(C)C1	10.1016/j.bmc.2009.04.068
		CHEMBL562328	196326	0	None	6	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	315	4	1	4	2.2	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCN(C)C1	10.1016/j.bmc.2009.04.068
		127038130	136623	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	347	8	1	2	4.5	CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12	10.1039/C5MD00190K
		CHEMBL3739824	136623	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	347	8	1	2	4.5	CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12	10.1039/C5MD00190K
		127038132	136814	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	361	9	1	2	4.9	CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12	10.1039/C5MD00190K
		CHEMBL3741561	136814	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	361	9	1	2	4.9	CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12	10.1039/C5MD00190K
		145979282	166675	0	None	16	3	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4281915	166675	0	None	16	3	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		10428383	3913	5	None	151	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm800974d
		7783	3913	5	None	151	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm800974d
		CHEMBL33185	3913	5	None	151	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm800974d
		45270052	195393	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	381	8	2	4	3.5	COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1016/j.bmc.2009.04.068
		CHEMBL552002	195393	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	381	8	2	4	3.5	COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1016/j.bmc.2009.04.068
		127038225	137988	0	None	13	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	338	5	1	4	3.8	COc1ccc2oc(-c3c(C)cccc3C)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		CHEMBL3764421	137988	0	None	13	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	338	5	1	4	3.8	COc1ccc2oc(-c3c(C)cccc3C)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
		10853020	98166	0	None	15	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	4	1	2	3.9	CCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
		CHEMBL273897	98166	0	None	15	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	4	1	2	3.9	CCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
		90666307	109384	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	389	8	2	3	3.9	C=CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12	10.1039/C1MD00149C
		CHEMBL3219328	109384	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells	ChEMBL	389	8	2	3	3.9	C=CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12	10.1039/C1MD00149C
		45270052	195393	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	381	8	2	4	3.5	COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1016/j.bmc.2009.04.068
		CHEMBL552002	195393	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting	ChEMBL	381	8	2	4	3.5	COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1016/j.bmc.2009.04.068
		49865149	15833	2	None	-2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC(C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1222986	15833	2	None	-2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC(C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
		10959837	207578	0	None	4	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	379	10	1	3	5.3	CCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		CHEMBL94919	207578	0	None	4	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.	ChEMBL	379	10	1	3	5.3	CCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
		49865270	15880	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(SC(C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
		CHEMBL1223131	15880	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(SC(C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
		9909783	67136	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	415	6	0	3	5.4	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2	10.1021/jm048956y
		CHEMBL187525	67136	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells	ChEMBL	415	6	0	3	5.4	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2	10.1021/jm048956y
		44389768	64543	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	426	9	2	2	5.5	CCNC(=O)NC[C@@H]1C[C@H]1c1c(Cl)ccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		CHEMBL181457	64543	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	426	9	2	2	5.5	CCNC(=O)NC[C@@H]1C[C@H]1c1c(Cl)ccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		20590665	123629	0	None	-14	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	391	9	1	2	5.3	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		CHEMBL361854	123629	0	None	-14	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	391	9	1	2	5.3	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
		11616029	77994	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	272	4	1	3	2.4	COc1ccc2c(c1)c(C1(CNC(C)=O)CC1)cn2C	10.1021/jm0512544
		CHEMBL209711	77994	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells	ChEMBL	272	4	1	3	2.4	COc1ccc2c(c1)c(C1(CNC(C)=O)CC1)cn2C	10.1021/jm0512544
		20590664	123672	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	390	9	2	2	5.4	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		CHEMBL362097	123672	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	390	9	2	2	5.4	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
		24763223	216	0	None	-74	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in rat NIH3T3 cells after 90 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in rat NIH3T3 cells after 90 mins	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1039/C5MD00190K
		8289	216	0	None	-74	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in rat NIH3T3 cells after 90 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in rat NIH3T3 cells after 90 mins	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1039/C5MD00190K
		CHEMBL3260987	216	0	None	-74	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in rat NIH3T3 cells after 90 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in rat NIH3T3 cells after 90 mins	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1039/C5MD00190K
		681	1465	72	None	-42	39	Human	5.0	pKi	=	5.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
		940	1465	72	None	-42	39	Human	5.0	pKi	=	5.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
		947	1465	72	None	-42	39	Human	5.0	pKi	=	5.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
		CHEMBL59	1465	72	None	-42	39	Human	5.0	pKi	=	5.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
		DB00988	1465	72	None	-42	39	Human	5.0	pKi	=	5.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
		54586061	60759	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	441	7	1	6	3.2	COc1ccc2c(CN3CCN(c4cccc(Cl)c4)CC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		CHEMBL1760952	60759	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells	ChEMBL	441	7	1	6	3.2	COc1ccc2c(CN3CCN(c4cccc(Cl)c4)CC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
		56671856	64451	0	None	-4	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	526	19	2	6	4.6	CC(=O)NCCN(C)c1cccc(OCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
		CHEMBL1813322	64451	0	None	-4	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	526	19	2	6	4.6	CC(=O)NCCN(C)c1cccc(OCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
		10513751	163294	1	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1cccc2[nH]c(CCNC(C)=O)cc12	10.1021/jm001125h
		CHEMBL418789	163294	1	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1cccc2[nH]c(CCNC(C)=O)cc12	10.1021/jm001125h
		10513752	108500	3	None	1	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2[nH]c(CCNC(C)=O)cc2c1	10.1021/jm001125h
		CHEMBL319970	108500	3	None	1	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2[nH]c(CCNC(C)=O)cc2c1	10.1021/jm001125h
		18522272	66089	0	None	-15	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	375	10	1	2	5.5	O=C(NCCCc1cccc2oc(CCCCc3ccccc3)cc12)C1CC1	10.1016/j.bmcl.2004.07.055
		CHEMBL183846	66089	0	None	-15	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	375	10	1	2	5.5	O=C(NCCCc1cccc2oc(CCCCc3ccccc3)cc12)C1CC1	10.1016/j.bmcl.2004.07.055
		16743294	92081	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	256	4	1	2	2.7	CC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
		CHEMBL241928	92081	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells	ChEMBL	256	4	1	2	2.7	CC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
		CHEMBL3109562	211090	0	None	2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells after 120 mins	ChEMBL		None	None	None		CCC1=C(C)C2=Cc3c(CCNC(C)=O)c4cc(OC)ccc4n3[B-](F)(F)[N+]2=C1C	10.1021/ml4004155
		145982333	166557	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		CHEMBL4279639	166557	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
		44394338	122043	0	None	-2	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	405	8	2	3	4.9	CCNC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
		CHEMBL359561	122043	0	None	-2	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B	ChEMBL	405	8	2	3	4.9	CCNC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
		1357	2485	139	None	1	9	Human	9.3	pKd	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
		1672	2485	139	None	1	9	Human	9.3	pKd	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
		224	2485	139	None	1	9	Human	9.3	pKd	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
		896	2485	139	None	1	9	Human	9.3	pKd	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
		CHEMBL45	2485	139	None	1	9	Human	9.3	pKd	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
		DB01065	2485	139	None	1	9	Human	9.3	pKd	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
		1358	124	41	125I-Iodomelatonin	870	2	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	None
		3976006	124	41	125I-Iodomelatonin	870	2	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	None
		CHEMBL285718	124	41	125I-Iodomelatonin	870	2	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	None
		198	313	126	125I-Iodomelatonin	1	6	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		82148	313	126	125I-Iodomelatonin	1	6	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		99	313	126	125I-Iodomelatonin	1	6	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		CHEMBL10878	313	126	125I-Iodomelatonin	1	6	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		DB06594	313	126	125I-Iodomelatonin	1	6	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	10.3	pKi	=	10.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	10.3	pKi	=	10.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	10.3	pKi	=	10.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	10.3	pKi	=	10.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	10.3	pKi	=	10.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	10.3	pKi	=	10.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		198	313	126	125I-Iodomelatonin	1	6	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		82148	313	126	125I-Iodomelatonin	1	6	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		99	313	126	125I-Iodomelatonin	1	6	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		CHEMBL10878	313	126	125I-Iodomelatonin	1	6	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		DB06594	313	126	125I-Iodomelatonin	1	6	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	10.0	pKi	=	10.0	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	10.0	pKi	=	10.0	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	10.0	pKi	=	10.0	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	10.0	pKi	=	10.0	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	10.0	pKi	=	10.0	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	10.0	pKi	=	10.0	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1349	1849	0	125I-Iodomelatonin	1	2	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	None
		5311134	1849	0	125I-Iodomelatonin	1	2	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1357	2485	139	125I-Mel	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Mel	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Mel	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Mel	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Mel	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Mel	1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		198	313	126	125I-Mel	1	6	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		82148	313	126	125I-Mel	1	6	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		99	313	126	125I-Mel	1	6	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		CHEMBL10878	313	126	125I-Mel	1	6	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		DB06594	313	126	125I-Mel	1	6	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1357	2485	139	125I-Mel	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Mel	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Mel	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Mel	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Mel	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Mel	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		198	313	126	UNDEFINED	1	6	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		82148	313	126	UNDEFINED	1	6	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		99	313	126	UNDEFINED	1	6	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		CHEMBL10878	313	126	UNDEFINED	1	6	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		DB06594	313	126	UNDEFINED	1	6	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		1354	3436	15	UNDEFINED	275	2	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	None
		22133318	3436	15	UNDEFINED	275	2	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	None
		CHEMBL490188	3436	15	UNDEFINED	275	2	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	None
		12985495	181386	0	UNDEFINED	213	2	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	377	8	2	3	4.5	CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	None
		CHEMBL476341	181386	0	UNDEFINED	213	2	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	377	8	2	3	4.5	CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		7922	1956	0	UNDEFINED	741	2	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	None
		9798456	1956	0	UNDEFINED	741	2	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	None
		CHEMBL476131	1956	0	UNDEFINED	741	2	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	None
		9818487	173533	0	UNDEFINED	141	2	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	319	5	1	2	4.2	COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1	None
		CHEMBL453138	173533	0	UNDEFINED	141	2	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	319	5	1	2	4.2	COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1	None
		1357	2485	139	UNDEFINED	1	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	UNDEFINED	1	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	UNDEFINED	1	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	UNDEFINED	1	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	UNDEFINED	1	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	UNDEFINED	1	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		44579259	187114	0	UNDEFINED	331	2	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	347	6	1	3	4.0	COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1	None
		CHEMBL491604	187114	0	UNDEFINED	331	2	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	347	6	1	3	4.0	COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1	None
		1349	1849	0	125I-Iodomelatonin	1	2	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	None
		5311134	1849	0	125I-Iodomelatonin	1	2	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		44579115	181835	0	UNDEFINED	162	2	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	348	6	2	3	4.2	CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	None
		CHEMBL477835	181835	0	UNDEFINED	162	2	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	348	6	2	3	4.2	CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	None
		12985494	190629	0	UNDEFINED	239	2	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	363	7	2	3	4.1	CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	None
		CHEMBL518113	190629	0	UNDEFINED	239	2	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	363	7	2	3	4.1	CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	None
		12985491	186980	0	UNDEFINED	91	2	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	411	6	1	2	5.1	COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1	None
		CHEMBL490595	186980	0	UNDEFINED	91	2	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	411	6	1	2	5.1	COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1	None
		44579260	187115	0	UNDEFINED	38	2	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	377	6	1	4	4.0	COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	None
		CHEMBL491605	187115	0	UNDEFINED	38	2	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	377	6	1	4	4.0	COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	None
		1357	2485	139	125I-Mel	1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Mel	1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Mel	1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Mel	1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Mel	1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Mel	1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		12985492	181831	0	UNDEFINED	177	2	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	459	6	1	2	5.1	COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1	None
		CHEMBL477833	181831	0	UNDEFINED	177	2	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	459	6	1	2	5.1	COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1	None
		44579163	182129	0	UNDEFINED	53	2	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	362	6	1	3	4.3	COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1	None
		CHEMBL478217	182129	0	UNDEFINED	53	2	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	362	6	1	3	4.3	COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1	None
		12985493	187092	0	UNDEFINED	213	2	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	363	7	1	3	4.3	COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	None
		CHEMBL491403	187092	0	UNDEFINED	213	2	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	363	7	1	3	4.3	COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	None
		1357	2485	139	125I-Mel	1	9	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Mel	1	9	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Mel	1	9	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Mel	1	9	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Mel	1	9	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Mel	1	9	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1358	124	41	125I-Iodomelatonin	870	2	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	None
		3976006	124	41	125I-Iodomelatonin	870	2	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	None
		CHEMBL285718	124	41	125I-Iodomelatonin	870	2	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		12985489	190236	0	UNDEFINED	3	2	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	349	6	2	3	3.7	COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1	None
		CHEMBL517502	190236	0	UNDEFINED	3	2	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	349	6	2	3	3.7	COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1	None
		198	313	126	None	1	6	Human	8.0	pKi	=	8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		82148	313	126	None	1	6	Human	8.0	pKi	=	8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		99	313	126	None	1	6	Human	8.0	pKi	=	8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		CHEMBL10878	313	126	None	1	6	Human	8.0	pKi	=	8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		DB06594	313	126	None	1	6	Human	8.0	pKi	=	8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		122162	2387	75	125I-Iodomelatonin	18	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
		1363	2387	75	125I-Iodomelatonin	18	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
		CHEMBL286615	2387	75	125I-Iodomelatonin	18	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
		1356	3288	99	None	-3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
		208902	3288	99	None	-3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
		2355	3288	99	None	-3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
		CHEMBL1218	3288	99	None	-3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
		DB00980	3288	99	None	-3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
		5	139	72	125I-Mel	-23442	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	125I-Mel	-23442	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	125I-Mel	-23442	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	125I-Mel	-23442	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		107	141	121	125I-Iodomelatonin	-14791	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	125I-Iodomelatonin	-14791	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	125I-Iodomelatonin	-14791	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		4209	3163	75	125I-Mel	-63095	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	3163	75	125I-Mel	-63095	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	3163	75	125I-Mel	-63095	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	3163	75	125I-Mel	-63095	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	3163	75	125I-Mel	-63095	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	3163	75	125I-Mel	-63095	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		122162	2387	75	125I-Iodomelatonin	18	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
		1363	2387	75	125I-Iodomelatonin	18	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
		CHEMBL286615	2387	75	125I-Iodomelatonin	18	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
		70547	113343	79	125I-Iodomelatonin	10	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
		CHEMBL33171	113343	79	125I-Iodomelatonin	10	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
		122162	2387	75	125I-Iodomelatonin	18	2	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
		1363	2387	75	125I-Iodomelatonin	18	2	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
		CHEMBL286615	2387	75	125I-Iodomelatonin	18	2	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
		903	112901	89	125I-Iodomelatonin	-1	2	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
		CHEMBL33103	112901	89	125I-Iodomelatonin	-1	2	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
		903	112901	89	125I-Iodomelatonin	-1	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
		CHEMBL33103	112901	89	125I-Iodomelatonin	-1	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		12985490	181220	0	UNDEFINED	12	2	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	349	6	2	3	3.7	COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1	None
		CHEMBL476132	181220	0	UNDEFINED	12	2	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	349	6	2	3	3.7	COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1	None
		122162	2387	75	125I-Iodomelatonin	18	2	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
		1363	2387	75	125I-Iodomelatonin	18	2	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
		CHEMBL286615	2387	75	125I-Iodomelatonin	18	2	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
		10427851	181833	0	UNDEFINED	407	2	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	348	6	2	3	3.7	COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1	None
		CHEMBL477834	181833	0	UNDEFINED	407	2	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	348	6	2	3	3.7	COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1	None
		164157684	216102	0	125I-Iodomelatonin	60	2	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	1094	24	4	18	8.7	CC(C)(C)OC(=O)N(C)CC(CN(C)C(=O)OC(C)(C)C)CSP(=O)(O)O.CNCC(CNC)CSP(=O)(OCOC(=O)C1=CC=CC=C1)OCOC(=O)C2=CC=CC=C2.C1=CC=C(C=C1)C(=O)OCCl	None
		903	112901	89	125I-Iodomelatonin	-1	2	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
		CHEMBL33103	112901	89	125I-Iodomelatonin	-1	2	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
		44579261	186979	0	UNDEFINED	87	2	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	363	6	2	3	3.9	COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1	None
		CHEMBL490594	186979	0	UNDEFINED	87	2	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	363	6	2	3	3.9	COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1	None
		12985496	182331	0	UNDEFINED	31	2	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	389	7	2	3	4.5	COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1	None
		CHEMBL478438	182331	0	UNDEFINED	31	2	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	389	7	2	3	4.5	COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1	None
		681	1465	72	None	-42	39	Human	8.3	pKi	=	8.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	None	-42	39	Human	8.3	pKi	=	8.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	None	-42	39	Human	8.3	pKi	=	8.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	None	-42	39	Human	8.3	pKi	=	8.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	None	-42	39	Human	8.3	pKi	=	8.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		1357	2485	139	125I-Iodomelatonin	1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	125I-Iodomelatonin	1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	125I-Iodomelatonin	1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	125I-Iodomelatonin	1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	125I-Iodomelatonin	1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	125I-Iodomelatonin	1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		None	216099	0	125I-Mel	1	2	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	218	2	2	4	1.5	CC(=O)N1C=C(C2=C1C=CC(=C2)O)CCN	None
		70547	113343	79	125I-Iodomelatonin	10	2	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
		CHEMBL33171	113343	79	125I-Iodomelatonin	10	2	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
		44579296	186794	0	UNDEFINED	5	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	376	6	2	3	4.2	COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1	None
		CHEMBL489170	186794	0	UNDEFINED	5	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	376	6	2	3	4.2	COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1	None
		12835	216103	0	125I-Iodomelatonin	6	2	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	191	3	2	2	1.7	COC1=CC2=C(C=C1)NC=C2CCO	None
		44579164	182130	0	UNDEFINED	14	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	406	7	2	4	4.8	CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	None
		CHEMBL478218	182130	0	UNDEFINED	14	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	406	7	2	4	4.8	CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	None
		10220503	3756	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
		4820	3756	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
		7393	3756	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
		CHEMBL2103822	3756	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
		DB09071	3756	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
		70547	113343	79	125I-Iodomelatonin	10	2	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
		CHEMBL33171	113343	79	125I-Iodomelatonin	10	2	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
		11196	1986	0	None	3	2	Human	5.5	pKi	=	5.5	Binding	For ERK1/2 activation.For ERK1/2 activation.	Guide to Pharmacology	888	18	3	11	5.9	COc1ccc2c(n1)c(CCNC(=O)C)cn2CCNC(=O)CCCCCN1c2ccc(cc2C(/C/1=C\C=C\C1=[N+](CC)c2c(C1(C)C)cc(cc2)S(=O)(=O)O)(C)C)S(=O)(=O)[O-]	28493341
		154699456	1986	0	None	3	2	Human	5.5	pKi	=	5.5	Binding	For ERK1/2 activation.For ERK1/2 activation.	Guide to Pharmacology	888	18	3	11	5.9	COc1ccc2c(n1)c(CCNC(=O)C)cn2CCNC(=O)CCCCCN1c2ccc(cc2C(/C/1=C\C=C\C1=[N+](CC)c2c(C1(C)C)cc(cc2)S(=O)(=O)O)(C)C)S(=O)(=O)[O-]	28493341
		115348	70	47	None	-4	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	12764576
		115348	70	47	None	-4	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	2991499
		115348	70	47	None	-4	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	9089668
		115348	70	47	None	-4	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	9618428
		1343	70	47	None	-4	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	12764576
		1343	70	47	None	-4	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	2991499
		1343	70	47	None	-4	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	9089668
		1343	70	47	None	-4	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	9618428
		CHEMBL289233	70	47	None	-4	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	12764576
		CHEMBL289233	70	47	None	-4	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	2991499
		CHEMBL289233	70	47	None	-4	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	9089668
		CHEMBL289233	70	47	None	-4	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	9618428
		DB08190	70	47	None	-4	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	12764576
		DB08190	70	47	None	-4	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	2991499
		DB08190	70	47	None	-4	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	9089668
		DB08190	70	47	None	-4	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	9618428
		1356	3288	99	None	-3	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
		1356	3288	99	None	-3	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	21182402
		208902	3288	99	None	-3	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
		208902	3288	99	None	-3	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	21182402
		2355	3288	99	None	-3	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
		2355	3288	99	None	-3	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	21182402
		CHEMBL1218	3288	99	None	-3	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
		CHEMBL1218	3288	99	None	-3	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	21182402
		DB00980	3288	99	None	-3	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
		DB00980	3288	99	None	-3	2	Human	10.0	pKi	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	21182402
		198	313	126	None	1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
		198	313	126	None	1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
		82148	313	126	None	1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
		82148	313	126	None	1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
		99	313	126	None	1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
		99	313	126	None	1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
		CHEMBL10878	313	126	None	1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
		CHEMBL10878	313	126	None	1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
		DB06594	313	126	None	1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
		DB06594	313	126	None	1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
		10220503	3756	0	None	2	2	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
		4820	3756	0	None	2	2	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
		7393	3756	0	None	2	2	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
		CHEMBL2103822	3756	0	None	2	2	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
		DB09071	3756	0	None	2	2	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
		24749950	3916	8	None	588	2	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	3.0	COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C	18052314
		7923	3916	8	None	588	2	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	3.0	COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C	18052314
		CHEMBL394676	3916	8	None	588	2	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	3.0	COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C	18052314
		1350	1990	0	None	1	3	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10420436
		1350	1990	0	None	1	3	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10737738
		1350	1990	0	None	-1	3	Mouse	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	24106342
		4172142	1990	0	None	1	3	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10420436
		4172142	1990	0	None	1	3	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10737738
		4172142	1990	0	None	-1	3	Mouse	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	24106342
		CHEMBL10009	1990	0	None	1	3	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10420436
		CHEMBL10009	1990	0	None	1	3	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10737738
		CHEMBL10009	1990	0	None	-1	3	Mouse	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	24106342
		53238181	934	0	None	741	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	21473625
		7780	934	0	None	741	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	21473625
		CHEMBL1774519	934	0	None	741	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	21473625
		57381997	2086	0	None	-	1	Human	11.0	pKi	=	11	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	7	1	2	4.1	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)CCC(C)C	22301214
		7781	2086	0	None	-	1	Human	11.0	pKi	=	11	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	7	1	2	4.1	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)CCC(C)C	22301214
		CHEMBL1946226	2086	0	None	-	1	Human	11.0	pKi	=	11	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	7	1	2	4.1	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)CCC(C)C	22301214
		121231413	3909	1	None	16982	2	Human	12.0	pKi	=	12	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	26334942
		9226	3909	1	None	16982	2	Human	12.0	pKi	=	12	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	26334942
		CHEMBL3612464	3909	1	None	16982	2	Human	12.0	pKi	=	12	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	26334942
		122162	2387	75	None	18	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10696085
		122162	2387	75	None	18	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	12764576
		122162	2387	75	None	18	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	2843633
		122162	2387	75	None	18	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9089668
		122162	2387	75	None	18	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9737724
		1363	2387	75	None	18	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10696085
		1363	2387	75	None	18	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	12764576
		1363	2387	75	None	18	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	2843633
		1363	2387	75	None	18	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9089668
		1363	2387	75	None	18	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9737724
		CHEMBL286615	2387	75	None	18	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10696085
		CHEMBL286615	2387	75	None	18	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	12764576
		CHEMBL286615	2387	75	None	18	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	2843633
		CHEMBL286615	2387	75	None	18	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9089668
		CHEMBL286615	2387	75	None	18	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9737724
		3366	1410	40	None	-	1	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	8	2	1	4.6	CCCCC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9840420
		3467177	1410	40	None	-	1	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	8	2	1	4.6	CCCCC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9840420
		CHEMBL1327247	1410	40	None	-	1	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	8	2	1	4.6	CCCCC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9840420
		7773	3915	0	None	12	2	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	296	3	2	2	2.6	COc1ccc2c(c1)C(CNC(=O)N)Cc1c(C2)cccc1	15293992
		86277838	3915	0	None	12	2	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	296	3	2	2	2.6	COc1ccc2c(c1)C(CNC(=O)N)Cc1c(C2)cccc1	15293992
		10428383	3913	5	None	151	2	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	15943478
		7783	3913	5	None	151	2	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	15943478
		CHEMBL33185	3913	5	None	151	2	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	15943478
		1347	162	56	None	1	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10696085
		1347	162	56	None	1	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	2991499
		1347	162	56	None	1	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9089668
		1864	162	56	None	1	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10696085
		1864	162	56	None	1	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	2991499
		1864	162	56	None	1	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9089668
		CHEMBL127421	162	56	None	1	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10696085
		CHEMBL127421	162	56	None	1	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	2991499
		CHEMBL127421	162	56	None	1	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9089668
		12324	3911	0	None	-2	2	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	30126274
		145966622	3911	0	None	-2	2	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	30126274
		CHEMBL4210086	3911	0	None	-2	2	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	30126274
		25210130	69	0	None	91	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	19193160
		7782	69	0	None	91	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	19193160
		CHEMBL514415	69	0	None	91	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	19193160
		11185529	3914	5	None	14	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	15293992
		11185529	3914	5	None	14	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	17907131
		7772	3914	5	None	14	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	15293992
		7772	3914	5	None	14	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	17907131
		CHEMBL189449	3914	5	None	14	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	15293992
		CHEMBL189449	3914	5	None	14	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	17907131
		1358	124	41	None	870	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	12764576
		1358	124	41	None	870	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9089668
		1358	124	41	None	870	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9737724
		3976006	124	41	None	870	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	12764576
		3976006	124	41	None	870	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9089668
		3976006	124	41	None	870	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9737724
		CHEMBL285718	124	41	None	870	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	12764576
		CHEMBL285718	124	41	None	870	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9089668
		CHEMBL285718	124	41	None	870	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9737724
		24750192	3917	13	None	1	2	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	18052314
		7777	3917	13	None	1	2	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	18052314
		CHEMBL237236	3917	13	None	1	2	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	18052314
		1359	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10420436
		1359	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10737738
		5311198	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10420436
		5311198	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10737738
		CHEMBL274438	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10420436
		CHEMBL274438	2170	21	None	125	2	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10737738
		24954989	1532	1	None	-6	2	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	21568291
		7774	1532	1	None	-6	2	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	21568291
		CHEMBL1802025	1532	1	None	-6	2	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	21568291
		7922	1956	0	None	741	2	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	18778943
		9798456	1956	0	None	741	2	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	18778943
		CHEMBL476131	1956	0	None	741	2	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	18778943
		71508234	705	0	None	38	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	23228808
		7924	705	0	None	38	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	23228808
		CHEMBL2326202	705	0	None	38	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	23228808
		1346	160	47	None	25	2	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	12764576
		1346	160	47	None	25	2	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	2991499
		1346	160	47	None	25	2	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9089668
		1346	160	47	None	25	2	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9618428
		1858	160	47	None	25	2	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	12764576
		1858	160	47	None	25	2	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	2991499
		1858	160	47	None	25	2	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9089668
		1858	160	47	None	25	2	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9618428
		CHEMBL34730	160	47	None	25	2	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	12764576
		CHEMBL34730	160	47	None	25	2	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	2991499
		CHEMBL34730	160	47	None	25	2	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9089668
		CHEMBL34730	160	47	None	25	2	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9618428
		1357	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
		1357	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
		1357	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
		1672	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
		1672	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
		1672	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
		224	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
		224	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
		224	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
		896	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
		896	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
		896	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
		CHEMBL45	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
		CHEMBL45	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
		CHEMBL45	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
		DB01065	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
		DB01065	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
		DB01065	2485	139	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
		129776	142	6	None	128	2	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	9089668
		1364	142	6	None	128	2	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	9089668
		CHEMBL339105	142	6	None	128	2	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	9089668
		1351	2395	21	None	1	2	Human	10.4	pKi	None	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	15302228
		219018	2395	21	None	1	2	Human	10.4	pKi	None	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	15302228
		CHEMBL4079759	2395	21	None	1	2	Human	10.4	pKi	None	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	15302228
		1362	3437	22	None	-39	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
		9870523	3437	22	None	-39	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
		CHEMBL429392	3437	22	None	-39	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
		1355	3438	5	None	-70	2	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
		9806449	3438	5	None	-70	2	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
		CHEMBL14453	3438	5	None	-70	2	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
		10849065	137	8	None	-4	2	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	11068946
		1345	137	8	None	-4	2	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	11068946
		CHEMBL126809	137	8	None	-4	2	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	11068946
		127856	3433	0	None	3	2	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	4	1	1	3.3	O=C(C1CCC1)NCCc1cccc2c1cccc2	12764576
		1360	3433	0	None	3	2	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	4	1	1	3.3	O=C(C1CCC1)NCCc1cccc2c1cccc2	12764576
		CHEMBL12296	3433	0	None	3	2	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	4	1	1	3.3	O=C(C1CCC1)NCCc1cccc2c1cccc2	12764576
		1361	3434	0	None	1	2	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	4	1	2	3.1	CCc1ccc2c(c1)c(CCNC(=O)C)cs2	12764576
		9816339	3434	0	None	1	2	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	4	1	2	3.1	CCc1ccc2c(c1)c(CCNC(=O)C)cs2	12764576
		1348	1845	5	None	100	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10205014
		1348	1845	5	None	100	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	9089668
		44208891	1845	5	None	100	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10205014
		44208891	1845	5	None	100	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	9089668
		CHEMBL3260983	1845	5	None	100	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10205014
		CHEMBL3260983	1845	5	None	100	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	9089668
		1354	3436	15	None	275	2	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	12764576
		22133318	3436	15	None	275	2	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	12764576
		CHEMBL490188	3436	15	None	275	2	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	12764576
		1353	3435	5	None	112	2	Human	9.6	pKi	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	12764576
		9998187	3435	5	None	112	2	Human	9.6	pKi	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	12764576
		CHEMBL33549	3435	5	None	112	2	Human	9.6	pKi	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	12764576
		1349	1849	0	None	1	2	Human	9.8	pKi	None	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	10696085
		1349	1849	0	None	1	2	Human	9.8	pKi	None	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	9618428
		5311134	1849	0	None	1	2	Human	9.8	pKi	None	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	10696085
		5311134	1849	0	None	1	2	Human	9.8	pKi	None	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	9618428

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Main reference

Ligand source activities (1 row/activity)