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Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	59304608	75259	0	None	3	4	Human	9.0	pEC50	=	9	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	262	3	2	4	0.9	O=c1[nH]c(=O)c2c(CCC3CCC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036954	75259	0	None	3	4	Human	9.0	pEC50	=	9	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	262	3	2	4	0.9	O=c1[nH]c(=O)c2c(CCC3CCC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	46890269	7374	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	381	7	3	3	4.5	CCCC1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
	CHEMBL1086353	7374	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	381	7	3	3	4.5	CCCC1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
	15605648	75257	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	290	3	2	4	1.1	O=c1[nH]c(=O)c2c(CCCC(F)(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036952	75257	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	290	3	2	4	1.1	O=c1[nH]c(=O)c2c(CCCC(F)(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	15604638	75262	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	276	5	2	4	1.3	O=c1[nH]c(=O)c2c(CCCCC3CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036957	75262	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	276	5	2	4	1.3	O=c1[nH]c(=O)c2c(CCCCC3CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	145957566	162287	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	426	3	1	5	5.0	COc1ccc(-c2cc3cc(C4Nc5ccccc5C(=O)N4C)cc(C)c3oc2=O)cc1	10.1016/j.ejmech.2018.04.037
	CHEMBL4164140	162287	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	426	3	1	5	5.0	COc1ccc(-c2cc3cc(C4Nc5ccccc5C(=O)N4C)cc(C)c3oc2=O)cc1	10.1016/j.ejmech.2018.04.037
	145957566	162287	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	426	3	1	5	5.0	COc1ccc(-c2cc3cc(C4Nc5ccccc5C(=O)N4C)cc(C)c3oc2=O)cc1	10.1016/j.ejmech.2018.04.037
	CHEMBL4164140	162287	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	426	3	1	5	5.0	COc1ccc(-c2cc3cc(C4Nc5ccccc5C(=O)N4C)cc(C)c3oc2=O)cc1	10.1016/j.ejmech.2018.04.037
	156010038	177030	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	414	8	3	4	5.1	CCCCn1cc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
	CHEMBL4632359	177030	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	414	8	3	4	5.1	CCCCn1cc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
	776464	93709	97	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	152	2	2	2	1.0	O=C(O)c1cc(C2CC2)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL247098	93709	97	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	152	2	2	2	1.0	O=C(O)c1cc(C2CC2)n[nH]1	10.1016/j.bmcl.2007.07.101
	117629482	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2011.12.041
	1588	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2011.12.041
	1594	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2011.12.041
	2835	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2011.12.041
	938	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2011.12.041
	CHEMBL573	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2011.12.041
	DB00627	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2011.12.041
	17751630	6745	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	487	7	3	7	2.8	NC(Cc1nc(-c2ccc(F)cn2)no1)C(=O)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1083743	6745	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	487	7	3	7	2.8	NC(Cc1nc(-c2ccc(F)cn2)no1)C(=O)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
	117629482	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	1588	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	1594	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	2835	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	938	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	CHEMBL573	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	DB00627	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	156016715	177675	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	415	8	3	5	4.5	CCCCn1cc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)n1	10.1016/j.bmcl.2020.127105
	CHEMBL4641756	177675	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	415	8	3	5	4.5	CCCCn1cc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)n1	10.1016/j.bmcl.2020.127105
	117629482	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.10.055
	1588	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.10.055
	1594	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.10.055
	2835	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.10.055
	938	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.10.055
	CHEMBL573	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.10.055
	DB00627	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.10.055
	117629482	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
	1588	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
	1594	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
	2835	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
	938	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
	CHEMBL573	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
	DB00627	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
	11594881	88638	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	319	5	2	2	4.1	O=C(CCc1ccc2ccccc2c1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	CHEMBL235740	88638	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	319	5	2	2	4.1	O=C(CCc1ccc2ccccc2c1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	117629482	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
	1588	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
	1594	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
	2835	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
	938	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
	CHEMBL573	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
	DB00627	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
	11523095	184187	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	347	7	2	2	4.9	O=C(CCCCc1ccc2ccccc2c1)Nc1ccccc1C(=O)O	10.1021/jm900151e
	CHEMBL483153	184187	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	347	7	2	2	4.9	O=C(CCCCc1ccc2ccccc2c1)Nc1ccccc1C(=O)O	10.1021/jm900151e
	117629482	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.039
	1588	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.039
	1594	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.039
	2835	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.039
	938	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.039
	CHEMBL573	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.039
	DB00627	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.039
	11594881	88638	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	319	5	2	2	4.1	O=C(CCc1ccc2ccccc2c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2008.08.030
	CHEMBL235740	88638	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	319	5	2	2	4.1	O=C(CCc1ccc2ccccc2c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2008.08.030
	776464	93709	97	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	152	2	2	2	1.0	O=C(O)c1cc(C2CC2)n[nH]1	10.1016/j.bmcl.2007.06.028
	CHEMBL247098	93709	97	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	152	2	2	2	1.0	O=C(O)c1cc(C2CC2)n[nH]1	10.1016/j.bmcl.2007.06.028
	117629482	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.001
	1588	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.001
	1594	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.001
	2835	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.001
	938	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.001
	CHEMBL573	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.001
	DB00627	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.001
	117629482	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
	1588	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
	1594	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
	2835	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
	938	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
	CHEMBL573	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
	DB00627	2823	140	None	-4	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
	54585613	61399	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	392	5	4	6	1.9	NC(Cc1cc2n(n1)-c1ccc(O)cc1CC2)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	CHEMBL1770174	61399	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	392	5	4	6	1.9	NC(Cc1cc2n(n1)-c1ccc(O)cc1CC2)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	57402396	69917	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	236	3	1	5	0.8	CCOc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939012	69917	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	236	3	1	5	0.8	CCOc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	57397200	69920	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	312	5	1	5	2.1	CCc1cc(=O)oc2nc(OCCc3ccccc3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939015	69920	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	312	5	1	5	2.1	CCc1cc(=O)oc2nc(OCCc3ccccc3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	57400597	69939	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	303	4	1	7	1.3	CCc1cc(=O)oc2nc(OCc3cc(C)on3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939034	69939	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	303	4	1	7	1.3	CCc1cc(=O)oc2nc(OCc3cc(C)on3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	145954324	162512	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	402	2	1	5	5.0	Cc1cc(C2Nc3ccccc3C(=O)N2C)cc2cc(-c3cccs3)c(=O)oc12	10.1016/j.ejmech.2018.04.037
	CHEMBL4167588	162512	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	402	2	1	5	5.0	Cc1cc(C2Nc3ccccc3C(=O)N2C)cc2cc(-c3cccs3)c(=O)oc12	10.1016/j.ejmech.2018.04.037
	90645405	112533	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	295	3	2	2	2.6	O=C(/C=C/C#Cc1ccccc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL3299113	112533	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	295	3	2	2	2.6	O=C(/C=C/C#Cc1ccccc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	145954324	162512	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	402	2	1	5	5.0	Cc1cc(C2Nc3ccccc3C(=O)N2C)cc2cc(-c3cccs3)c(=O)oc12	10.1016/j.ejmech.2018.04.037
	CHEMBL4167588	162512	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	402	2	1	5	5.0	Cc1cc(C2Nc3ccccc3C(=O)N2C)cc2cc(-c3cccs3)c(=O)oc12	10.1016/j.ejmech.2018.04.037
	11672831	76040	4	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	192	1	2	2	1.4	CC1(C)C2Cc3c(C(=O)O)n[nH]c3C21	10.1021/jm2010964
	CHEMBL2057235	76040	4	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	192	1	2	2	1.4	CC1(C)C2Cc3c(C(=O)O)n[nH]c3C21	10.1021/jm2010964
	776416	18938	108	None	-5	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity against human GPR109a assessed as GTPgammaS bindingAgonist activity against human GPR109a assessed as GTPgammaS binding	ChEMBL	152	1	2	2	0.6	O=C(O)c1n[nH]c2c1CCC2	10.1021/jm800258p
	CHEMBL128604	18938	108	None	-5	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity against human GPR109a assessed as GTPgammaS bindingAgonist activity against human GPR109a assessed as GTPgammaS binding	ChEMBL	152	1	2	2	0.6	O=C(O)c1n[nH]c2c1CCC2	10.1021/jm800258p
	11550911	95188	1	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	280	3	2	2	2.5	O=C(O)c1cc(Cc2cccc(Br)c2)[nH]n1	10.1016/j.bmcl.2007.06.028
	CHEMBL255877	95188	1	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	280	3	2	2	2.5	O=C(O)c1cc(Cc2cccc(Br)c2)[nH]n1	10.1016/j.bmcl.2007.06.028
	57397201	69928	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	328	5	1	6	2.0	CCc1cc(=O)oc2nc(OCc3ccc(OC)cc3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939023	69928	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	328	5	1	6	2.0	CCc1cc(=O)oc2nc(OCc3ccc(OC)cc3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	53325342	58038	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	336	6	1	4	3.3	O=c1cc(CCCC2(C3CC3)CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1672642	58038	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	336	6	1	4	3.3	O=c1cc(CCCC2(C3CC3)CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	24954941	58041	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	296	4	1	4	2.5	O=c1cc(CCC2CCC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1672732	58041	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	296	4	1	4	2.5	O=c1cc(CCC2CCC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	11159621	2548	46	None	1	3	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulationAgonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulation	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	5784	2548	46	None	1	3	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulationAgonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulation	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	CHEMBL456145	2548	46	None	1	3	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulationAgonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulation	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	DB05939	2548	46	None	1	3	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulationAgonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulation	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	776421	89928	108	None	30	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	154	2	2	2	1.2	CC(C)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL238002	89928	108	None	30	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	154	2	2	2	1.2	CC(C)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.07.101
	13153555	93863	27	None	42	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	5	2	2	1.8	CCCCCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.07.101
	CHEMBL247921	93863	27	None	42	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	5	2	2	1.8	CCCCCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.07.101
	46890327	6600	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	451	6	3	3	5.2	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1083138	6600	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	451	6	3	3	5.2	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
	59304946	75247	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	268	4	2	5	0.5	CSCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036828	75247	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	268	4	2	5	0.5	CSCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	11483496	126	0	None	14	2	Human	7.0	pEC50	=	7.0	Functional	Activity at GPR109a assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109a assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm800896z
	1589	126	0	None	14	2	Human	7.0	pEC50	=	7.0	Functional	Activity at GPR109a assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109a assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm800896z
	CHEMBL375493	126	0	None	14	2	Human	7.0	pEC50	=	7.0	Functional	Activity at GPR109a assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109a assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm800896z
	11483496	126	0	None	14	2	Human	7.0	pEC50	=	7.0	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1589	126	0	None	14	2	Human	7.0	pEC50	=	7.0	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL375493	126	0	None	14	2	Human	7.0	pEC50	=	7.0	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	135416383	184909	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	368	5	3	5	2.7	O=C(CCc1noc2c1CCc1cc(O)ccc1-2)NC1=C(C(=O)O)CCC1	10.1021/jm900151e
	CHEMBL485326	184909	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	368	5	3	5	2.7	O=C(CCc1noc2c1CCc1cc(O)ccc1-2)NC1=C(C(=O)O)CCC1	10.1021/jm900151e
	59304655	75246	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	252	4	2	5	-0.3	COCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036827	75246	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	252	4	2	5	-0.3	COCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	137652577	158760	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	329	3	3	3	2.5	O=C(/C=C/C#Cc1ccc(O)cc1F)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4093990	158760	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	329	3	3	3	2.5	O=C(/C=C/C#Cc1ccc(O)cc1F)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	11184165	83454	0	None	5	2	Human	6.0	pEC50	=	6.0	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	246	3	1	3	2.0	CCc1cccc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	CHEMBL219950	83454	0	None	5	2	Human	6.0	pEC50	=	6.0	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	246	3	1	3	2.0	CCc1cccc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	12003788	194941	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	278	2	2	2	2.7	O=C(O)c1n[nH]c2c1CC(c1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.06.054
	CHEMBL1237148	194941	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	278	2	2	2	2.7	O=C(O)c1n[nH]c2c1CC(c1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.06.054
	CHEMBL542000	194941	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	278	2	2	2	2.7	O=C(O)c1n[nH]c2c1CC(c1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.06.054
	12003787	195842	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	296	2	2	2	2.8	O=C(O)c1n[nH]c2c1CC(c1cc(F)cc(F)c1F)CC2	10.1016/j.bmcl.2009.06.054
	CHEMBL558463	195842	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	296	2	2	2	2.8	O=C(O)c1n[nH]c2c1CC(c1cc(F)cc(F)c1F)CC2	10.1016/j.bmcl.2009.06.054
	16048917	154014	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	407	4	2	6	2.7	COc1cccc2ncc(N3CCN(C(=O)Nc4ccccc4C(=O)O)CC3)nc12	10.1016/j.bmcl.2007.10.055
	CHEMBL398414	154014	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	407	4	2	6	2.7	COc1cccc2ncc(N3CCN(C(=O)Nc4ccccc4C(=O)O)CC3)nc12	10.1016/j.bmcl.2007.10.055
	135401974	154723	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	393	3	3	6	2.4	O=C(O)c1ccccc1NC(=O)N1CCN(c2cnc3cccc(O)c3n2)CC1	10.1016/j.bmcl.2007.10.055
	CHEMBL399859	154723	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	393	3	3	6	2.4	O=C(O)c1ccccc1NC(=O)N1CCN(c2cnc3cccc(O)c3n2)CC1	10.1016/j.bmcl.2007.10.055
	46889338	6724	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	214	2	2	4	0.7	C=C[C@H]1[C@H]2Cc3c(-c4nnn[nH]4)n[nH]c3[C@@H]12	10.1016/j.bmcl.2010.03.062
	CHEMBL1083683	6724	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	214	2	2	4	0.7	C=C[C@H]1[C@H]2Cc3c(-c4nnn[nH]4)n[nH]c3[C@@H]12	10.1016/j.bmcl.2010.03.062
	53317449	58061	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	222	2	2	5	-0.1	CCc1cc(=O)oc2nc(CO)[nH]c(=O)c12	10.1021/ml100251u
	CHEMBL1672767	58061	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	222	2	2	5	-0.1	CCc1cc(=O)oc2nc(CO)[nH]c(=O)c12	10.1021/ml100251u
	57413448	76351	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	234	5	2	2	2.6	CCCCC[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	CHEMBL2059226	76351	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	234	5	2	2	2.6	CCCCC[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	57395376	69926	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	328	5	1	6	2.0	CCc1cc(=O)oc2nc(OCc3ccccc3OC)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939021	69926	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	328	5	1	6	2.0	CCc1cc(=O)oc2nc(OCc3ccccc3OC)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	57412210	76115	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	178	1	2	2	1.0	C[C@@H]1[C@@H]2c3[nH]nc(C(=O)O)c3C[C@H]12	10.1021/jm2010964
	CHEMBL2057616	76115	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	178	1	2	2	1.0	C[C@@H]1[C@@H]2c3[nH]nc(C(=O)O)c3C[C@H]12	10.1021/jm2010964
	15605571	75235	2	None	-1	5	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	236	3	2	4	0.5	CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036813	75235	2	None	-1	5	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	236	3	2	4	0.5	CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	49763030	76117	31	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	164	1	2	2	0.8	O=C(O)c1n[nH]c2c1C[C@H]1C[C@@H]21	10.1021/jm2010964
	CHEMBL2057618	76117	31	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	164	1	2	2	0.8	O=C(O)c1n[nH]c2c1C[C@H]1C[C@@H]21	10.1021/jm2010964
	117629482	2823	140	None	-4	4	Human	6.9	pEC50	=	6.9	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm070022x
	1588	2823	140	None	-4	4	Human	6.9	pEC50	=	6.9	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm070022x
	1594	2823	140	None	-4	4	Human	6.9	pEC50	=	6.9	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm070022x
	2835	2823	140	None	-4	4	Human	6.9	pEC50	=	6.9	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm070022x
	938	2823	140	None	-4	4	Human	6.9	pEC50	=	6.9	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm070022x
	CHEMBL573	2823	140	None	-4	4	Human	6.9	pEC50	=	6.9	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm070022x
	DB00627	2823	140	None	-4	4	Human	6.9	pEC50	=	6.9	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm070022x
	135800177	145951	7	None	24	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	353	6	3	6	2.7	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	CHEMBL391813	145951	7	None	24	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	353	6	3	6	2.7	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	11617852	184535	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	381	5	3	6	3.5	O=C(CCc1cn2c(n1)sc1cc(O)ccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
	CHEMBL484783	184535	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	381	5	3	6	3.5	O=C(CCc1cn2c(n1)sc1cc(O)ccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
	25101223	1152	7	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	428	7	1	5	5.0	C[C@@H](NC(=O)c1cnc2n(c1C)ncc2c1ccc(cc1)C(C)C)COc1ccccc1	10.1016/j.bmcl.2008.08.039
	5795	1152	7	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	428	7	1	5	5.0	C[C@@H](NC(=O)c1cnc2n(c1C)ncc2c1ccc(cc1)C(C)C)COc1ccccc1	10.1016/j.bmcl.2008.08.039
	CHEMBL490599	1152	7	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	428	7	1	5	5.0	C[C@@H](NC(=O)c1cnc2n(c1C)ncc2c1ccc(cc1)C(C)C)COc1ccccc1	10.1016/j.bmcl.2008.08.039
	117629482	2823	140	None	-4	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.06.028
	1588	2823	140	None	-4	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.06.028
	1594	2823	140	None	-4	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.06.028
	2835	2823	140	None	-4	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.06.028
	938	2823	140	None	-4	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.06.028
	CHEMBL573	2823	140	None	-4	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.06.028
	DB00627	2823	140	None	-4	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.06.028
	135800177	145951	7	None	24	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	353	6	3	6	2.7	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	CHEMBL391813	145951	7	None	24	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	353	6	3	6	2.7	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	11992586	195500	9	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	217	4	3	3	1.7	O=C(O)c1cc(NCc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL553435	195500	9	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	217	4	3	3	1.7	O=C(O)c1cc(NCc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11160694	138156	1	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	236	2	1	3	1.6	CC1(c2cccc(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL376889	138156	1	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	236	2	1	3	1.6	CC1(c2cccc(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	4268702	169652	8	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	327	5	2	3	3.7	CC(C)(C)c1ccc(OCC(=O)Nc2ccccc2C(=O)O)cc1	10.1016/j.bmcl.2008.08.030
	CHEMBL443733	169652	8	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	327	5	2	3	3.7	CC(C)(C)c1ccc(OCC(=O)Nc2ccccc2C(=O)O)cc1	10.1016/j.bmcl.2008.08.030
	145984458	165495	0	None	-1	2	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat GPR109A expressed in T-REx-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin stimulation and measured after 20 mins by TR-FRET assayAgonist activity at rat GPR109A expressed in T-REx-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin stimulation and measured after 20 mins by TR-FRET assay	ChEMBL	600	7	2	8	4.6	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3c(s2)C[Si](C)(c2ccc(OC)cc2)CC3)cc1N1CCOCC1	10.1021/acs.jmedchem.7b00718
	CHEMBL4240407	165495	0	None	-1	2	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat GPR109A expressed in T-REx-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin stimulation and measured after 20 mins by TR-FRET assayAgonist activity at rat GPR109A expressed in T-REx-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin stimulation and measured after 20 mins by TR-FRET assay	ChEMBL	600	7	2	8	4.6	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3c(s2)C[Si](C)(c2ccc(OC)cc2)CC3)cc1N1CCOCC1	10.1021/acs.jmedchem.7b00718
	11322761	141606	1	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)cc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL385103	141606	1	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)cc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	44441318	93791	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	228	2	2	2	2.2	O=C(O)c1[nH]nc2c1CCC2c1ccccc1	10.1016/j.bmcl.2007.06.028
	CHEMBL247527	93791	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	228	2	2	2	2.2	O=C(O)c1[nH]nc2c1CCC2c1ccccc1	10.1016/j.bmcl.2007.06.028
	11845295	149578	42	None	-1	2	Mouse	4.9	pEC50	=	4.9	Functional	Agonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulationAgonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulation	ChEMBL	166	1	2	2	1.2	CC1CCc2c(C(=O)O)n[nH]c21	10.1021/jm800258p
	CHEMBL394688	149578	42	None	-1	2	Mouse	4.9	pEC50	=	4.9	Functional	Agonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulationAgonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulation	ChEMBL	166	1	2	2	1.2	CC1CCc2c(C(=O)O)n[nH]c21	10.1021/jm800258p
	44441310	149283	4	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	170	4	2	3	0.3	COCCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.06.028
	CHEMBL394464	149283	4	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	170	4	2	3	0.3	COCCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.06.028
	57393654	69916	2	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	222	2	1	5	0.4	CCc1cc(=O)oc2nc(OC)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939011	69916	2	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	222	2	1	5	0.4	CCc1cc(=O)oc2nc(OC)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	882926	85607	13	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR109aAgonist activity at GPR109a	ChEMBL	301	6	2	4	2.4	COc1ccc(OCC(=O)Nc2ccccc2C(=O)O)cc1	10.1021/jm200371q
	CHEMBL228244	85607	13	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR109aAgonist activity at GPR109a	ChEMBL	301	6	2	4	2.4	COc1ccc(OCC(=O)Nc2ccccc2C(=O)O)cc1	10.1021/jm200371q
	882926	85607	13	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	301	6	2	4	2.4	COc1ccc(OCC(=O)Nc2ccccc2C(=O)O)cc1	10.1016/j.bmcl.2008.08.030
	CHEMBL228244	85607	13	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	301	6	2	4	2.4	COc1ccc(OCC(=O)Nc2ccccc2C(=O)O)cc1	10.1016/j.bmcl.2008.08.030
	90645413	112483	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	335	4	2	2	4.0	O=C(O)C1=C(NC(=O)[C@@H]2C[C@H]2c2ccc3ccccc3c2)CCCC1	10.1016/j.bmc.2014.05.011
	CHEMBL3298703	112483	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	335	4	2	2	4.0	O=C(O)C1=C(NC(=O)[C@@H]2C[C@H]2c2ccc3ccccc3c2)CCCC1	10.1016/j.bmc.2014.05.011
	53326893	58048	1	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	260	1	1	4	1.5	CCc1cc(=O)oc2nc(C(F)(F)F)[nH]c(=O)c12	10.1021/ml100251u
	CHEMBL1672742	58048	1	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	260	1	1	4	1.5	CCc1cc(=O)oc2nc(C(F)(F)F)[nH]c(=O)c12	10.1021/ml100251u
	24954204	58056	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	284	5	1	4	2.5	CCCCCc1cc(=O)oc2nc(C(F)F)[nH]c(=O)c12	10.1021/ml100251u
	CHEMBL1672751	58056	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	284	5	1	4	2.5	CCCCCc1cc(=O)oc2nc(C(F)F)[nH]c(=O)c12	10.1021/ml100251u
	57413453	76473	1	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	190	2	2	2	1.2	C=C[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	CHEMBL2059825	76473	1	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	190	2	2	2	1.2	C=C[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	46889360	7107	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	228	3	2	4	1.1	C=CC[C@@H]1[C@@H]2c3[nH]nc(-c4nnn[nH]4)c3C[C@H]12	10.1016/j.bmcl.2010.03.062
	CHEMBL1085200	7107	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	228	3	2	4	1.1	C=CC[C@@H]1[C@@H]2c3[nH]nc(-c4nnn[nH]4)c3C[C@H]12	10.1016/j.bmcl.2010.03.062
	15605654	75258	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	248	3	2	4	0.5	O=c1[nH]c(=O)c2c(CCC3CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036953	75258	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	248	3	2	4	0.5	O=c1[nH]c(=O)c2c(CCC3CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	46890299	7215	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	433	6	3	3	5.0	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccc(F)cc2)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1085655	7215	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	433	6	3	3	5.0	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccc(F)cc2)CC1	10.1016/j.bmcl.2010.04.001
	53322717	58046	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	322	4	1	4	2.9	O=c1cc(CCC2CC3(CC3)C2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1672738	58046	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	322	4	1	4	2.9	O=c1cc(CCC2CC3(CC3)C2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	137633734	156321	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	311	3	3	3	2.3	O=C(/C=C/C#Cc1ccc(O)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4065654	156321	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	311	3	3	3	2.3	O=C(/C=C/C#Cc1ccc(O)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	137641317	157011	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	383	6	2	2	5.0	O=C(CCc1ccc(-c2ccccc2Cl)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4073374	157011	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	383	6	2	2	5.0	O=C(CCc1ccc(-c2ccccc2Cl)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	1595	259	49	None	4	2	Human	5.9	pEC50	=	5.9	Functional	Activity at GPR109a assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109a assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	51576	259	49	None	4	2	Human	5.9	pEC50	=	5.9	Functional	Activity at GPR109a assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109a assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	CHEMBL278488	259	49	None	4	2	Human	5.9	pEC50	=	5.9	Functional	Activity at GPR109a assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109a assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	1595	259	49	None	4	2	Human	5.9	pEC50	=	5.9	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	51576	259	49	None	4	2	Human	5.9	pEC50	=	5.9	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	CHEMBL278488	259	49	None	4	2	Human	5.9	pEC50	=	5.9	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	1595	259	49	None	4	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at N-terminal HA-tagged GPR109a receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109a receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmcl.2009.05.108
	51576	259	49	None	4	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at N-terminal HA-tagged GPR109a receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109a receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmcl.2009.05.108
	CHEMBL278488	259	49	None	4	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at N-terminal HA-tagged GPR109a receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109a receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmcl.2009.05.108
	24741310	89622	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	352	6	3	6	2.2	O=C(CCc1ccn(-c2ccc(O)cn2)n1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	CHEMBL237543	89622	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	352	6	3	6	2.2	O=C(CCc1ccn(-c2ccc(O)cn2)n1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	44580038	186949	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	444	8	1	6	4.6	COc1ccc(OCCNC(=O)c2cnc3c(-c4ccc(C(C)C)cc4)cnn3c2C)cc1	10.1016/j.bmcl.2008.08.039
	CHEMBL490221	186949	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	444	8	1	6	4.6	COc1ccc(OCCNC(=O)c2cnc3c(-c4ccc(C(C)C)cc4)cnn3c2C)cc1	10.1016/j.bmcl.2008.08.039
	44579693	187091	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	428	7	1	5	4.9	Cc1cccc(OCCNC(=O)c2cnc3c(-c4ccc(C(C)C)cc4)cnn3c2C)c1	10.1016/j.bmcl.2008.08.039
	CHEMBL491396	187091	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	428	7	1	5	4.9	Cc1cccc(OCCNC(=O)c2cnc3c(-c4ccc(C(C)C)cc4)cnn3c2C)c1	10.1016/j.bmcl.2008.08.039
	13557	1106	111	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	127	1	1	3	0.7	CC1=NOC(=C1)C(=O)O	10.1016/j.bmcl.2007.06.028
	853085	1106	111	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	127	1	1	3	0.7	CC1=NOC(=C1)C(=O)O	10.1016/j.bmcl.2007.06.028
	CHEMBL393428	1106	111	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	127	1	1	3	0.7	CC1=NOC(=C1)C(=O)O	10.1016/j.bmcl.2007.06.028
	12003788	194941	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	278	2	2	2	2.7	O=C(O)c1n[nH]c2c1CC(c1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.06.054
	CHEMBL1237148	194941	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	278	2	2	2	2.7	O=C(O)c1n[nH]c2c1CC(c1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.06.054
	CHEMBL542000	194941	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	278	2	2	2	2.7	O=C(O)c1n[nH]c2c1CC(c1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.06.054
	12002717	196742	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	302	2	2	4	2.1	Fc1ccc(F)c(C2CCc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.06.054
	CHEMBL565163	196742	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	302	2	2	4	2.1	Fc1ccc(F)c(C2CCc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.06.054
	15605357	75240	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	224	1	3	5	-0.8	CC(O)c1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036821	75240	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	224	1	3	5	-0.8	CC(O)c1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	145984088	165815	0	None	-1	2	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat GPR109A expressed in T-REx-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin stimulation and measured after 20 mins by TR-FRET assayAgonist activity at rat GPR109A expressed in T-REx-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin stimulation and measured after 20 mins by TR-FRET assay	ChEMBL	630	8	2	9	4.6	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3c(s2)C[Si](C)(c2c(OC)cccc2OC)CC3)cc1N1CCOCC1	10.1021/acs.jmedchem.7b00718
	CHEMBL4248415	165815	0	None	-1	2	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat GPR109A expressed in T-REx-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin stimulation and measured after 20 mins by TR-FRET assayAgonist activity at rat GPR109A expressed in T-REx-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin stimulation and measured after 20 mins by TR-FRET assay	ChEMBL	630	8	2	9	4.6	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3c(s2)C[Si](C)(c2c(OC)cccc2OC)CC3)cc1N1CCOCC1	10.1021/acs.jmedchem.7b00718
	16048995	94655	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	375	3	2	3	3.9	O=C(O)c1ccccc1NC(=O)N1CCN(c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2007.10.055
	CHEMBL252505	94655	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	375	3	2	3	3.9	O=C(O)c1ccccc1NC(=O)N1CCN(c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2007.10.055
	16048992	94682	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	403	4	2	5	3.2	O=C(O)c1ccccc1NC(=O)N1CCN(c2nccc(-c3ccccc3)n2)CC1	10.1016/j.bmcl.2007.10.055
	CHEMBL252707	94682	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	403	4	2	5	3.2	O=C(O)c1ccccc1NC(=O)N1CCN(c2nccc(-c3ccccc3)n2)CC1	10.1016/j.bmcl.2007.10.055
	15605498	69929	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	366	4	1	5	3.0	CCc1cc(=O)oc2nc(OCc3ccccc3C(F)(F)F)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939024	69929	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	366	4	1	5	3.0	CCc1cc(=O)oc2nc(OCc3ccccc3C(F)(F)F)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	88707	93757	141	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	201	1	1	2	1.5	O=C(O)c1cncc(Br)c1	10.1016/j.bmcl.2007.06.028
	CHEMBL247336	93757	141	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	201	1	1	2	1.5	O=C(O)c1cncc(Br)c1	10.1016/j.bmcl.2007.06.028
	24954940	69949	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	336	4	1	5	2.3	CCC#CCOc1nc2oc(=O)cc(Cc3ccccc3)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939044	69949	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	336	4	1	5	2.3	CCC#CCOc1nc2oc(=O)cc(Cc3ccccc3)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	46890401	7287	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	460	7	3	4	4.9	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)NC1=C(C(=O)O)CC(c2cccnc2F)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1086031	7287	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	460	7	3	4	4.9	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)NC1=C(C(=O)O)CC(c2cccnc2F)CC1	10.1016/j.bmcl.2010.04.001
	57393655	69921	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	266	5	1	6	0.5	CCc1cc(=O)oc2nc(OCCOC)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939016	69921	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	266	5	1	6	0.5	CCc1cc(=O)oc2nc(OCCOC)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	57392461	69871	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	240	1	1	5	-0.1	Cc1cc(=O)oc2nc([S+](C)[O-])[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1938888	69871	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	240	1	1	5	-0.1	Cc1cc(=O)oc2nc([S+](C)[O-])[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	11514051	76112	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	218	1	2	2	1.9	O=C(O)c1n[nH]c2c1CC1C2C12CCCC2	10.1021/jm2010964
	CHEMBL2057610	76112	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	218	1	2	2	1.9	O=C(O)c1n[nH]c2c1CC1C2C12CCCC2	10.1021/jm2010964
	135899178	16210	0	None	-2	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat GPR109A receptor assessed as GTPgammaS bindingAgonist activity at rat GPR109A receptor assessed as GTPgammaS binding	ChEMBL	315	5	1	4	2.7	O=c1[nH]c(COCCc2cccc(Cl)c2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	CHEMBL1224219	16210	0	None	-2	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat GPR109A receptor assessed as GTPgammaS bindingAgonist activity at rat GPR109A receptor assessed as GTPgammaS binding	ChEMBL	315	5	1	4	2.7	O=c1[nH]c(COCCc2cccc(Cl)c2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	156016157	177778	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	430	8	3	4	3.2	CCCCN1CC(C(=O)O)=C(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)C1=O	10.1016/j.bmcl.2020.127105
	CHEMBL4643073	177778	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	430	8	3	4	3.2	CCCCN1CC(C(=O)O)=C(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)C1=O	10.1016/j.bmcl.2020.127105
	44579780	187160	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	442	8	1	5	4.8	COCC(Cc1ccccc1)NC(=O)c1cnc2c(-c3ccc(C(C)C)cc3)cnn2c1C	10.1016/j.bmcl.2008.08.039
	CHEMBL492027	187160	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	442	8	1	5	4.8	COCC(Cc1ccccc1)NC(=O)c1cnc2c(-c3ccc(C(C)C)cc3)cnn2c1C	10.1016/j.bmcl.2008.08.039
	117629482	2823	140	None	-4	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.030
	1588	2823	140	None	-4	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.030
	1594	2823	140	None	-4	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.030
	2835	2823	140	None	-4	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.030
	938	2823	140	None	-4	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.030
	CHEMBL573	2823	140	None	-4	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.030
	DB00627	2823	140	None	-4	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.030
	90645401	112481	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	337	4	3	3	3.6	O=C(/C=C/c1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	CHEMBL3298701	112481	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	337	4	3	3	3.6	O=C(/C=C/c1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	1591	131	63	None	33	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.06.028
	6485181	131	63	None	33	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.06.028
	CHEMBL428730	131	63	None	33	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.06.028
	156020831	178070	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	386	8	4	8	1.5	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1cn(CCO)cc1C(=O)O	10.1016/j.bmcl.2020.127105
	CHEMBL4647398	178070	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	386	8	4	8	1.5	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1cn(CCO)cc1C(=O)O	10.1016/j.bmcl.2020.127105
	24954566	58032	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	310	4	1	4	2.9	O=c1cc(CCC2CCCC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1672637	58032	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	310	4	1	4	2.9	O=c1cc(CCC2CCCC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	57413544	76107	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	208	3	2	3	0.6	COC[C@H]1[C@H]2c3[nH]nc(C(=O)O)c3C[C@H]21	10.1021/jm2010964
	CHEMBL2057603	76107	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	208	3	2	3	0.6	COC[C@H]1[C@H]2c3[nH]nc(C(=O)O)c3C[C@H]21	10.1021/jm2010964
	46889361	6831	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	228	3	2	4	1.1	C=CC[C@H]1[C@@H]2c3[nH]nc(-c4nnn[nH]4)c3C[C@@H]21	10.1016/j.bmcl.2010.03.062
	CHEMBL1083988	6831	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	228	3	2	4	1.1	C=CC[C@H]1[C@@H]2c3[nH]nc(-c4nnn[nH]4)c3C[C@@H]21	10.1016/j.bmcl.2010.03.062
	11660694	178068	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	369	5	3	3	4.5	O=C(CCc1ccc2c(Cl)c(O)ccc2c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2020.127105
	CHEMBL4647392	178068	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	369	5	3	3	4.5	O=C(CCc1ccc2c(Cl)c(O)ccc2c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2020.127105
	24955646	58034	0	None	-2	4	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	310	5	1	4	2.9	CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	CHEMBL1672639	58034	0	None	-2	4	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	310	5	1	4	2.9	CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	156019027	177797	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	415	8	3	5	4.5	CCCCn1cc(C(=O)O)c(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)n1	10.1016/j.bmcl.2020.127105
	CHEMBL4643451	177797	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	415	8	3	5	4.5	CCCCn1cc(C(=O)O)c(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)n1	10.1016/j.bmcl.2020.127105
	156020512	178104	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	403	9	3	8	2.3	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1cn(CCCF)cc1C(=O)O	10.1016/j.bmcl.2020.127105
	CHEMBL4647933	178104	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	403	9	3	8	2.3	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1cn(CCCF)cc1C(=O)O	10.1016/j.bmcl.2020.127105
	12430656	147734	88	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	129	1	1	3	0.8	O=C(O)c1cnsc1	10.1016/j.bmcl.2007.06.028
	CHEMBL393226	147734	88	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	129	1	1	3	0.8	O=C(O)c1cnsc1	10.1016/j.bmcl.2007.06.028
	136000669	61404	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	382	7	4	7	1.9	CN[C@@H](Cc1nc(-c2ccc(O)cc2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	CHEMBL1770179	61404	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	382	7	4	7	1.9	CN[C@@H](Cc1nc(-c2ccc(O)cc2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	44433527	88534	11	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	150	1	2	4	-0.1	Cc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL235228	88534	11	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	150	1	2	4	-0.1	Cc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	44433531	88537	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	168	1	2	4	0.0	Cc1[nH]nc(-c2nnn[nH]2)c1F	10.1016/j.bmcl.2007.07.101
	CHEMBL235231	88537	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	168	1	2	4	0.0	Cc1[nH]nc(-c2nnn[nH]2)c1F	10.1016/j.bmcl.2007.07.101
	46889339	7180	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	214	2	2	4	0.7	C=C[C@@H]1[C@H]2Cc3c(-c4nnn[nH]4)n[nH]c3[C@@H]12	10.1016/j.bmcl.2010.03.062
	CHEMBL1085534	7180	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	214	2	2	4	0.7	C=C[C@@H]1[C@H]2Cc3c(-c4nnn[nH]4)n[nH]c3[C@@H]12	10.1016/j.bmcl.2010.03.062
	135416394	2560	52	None	15	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
	5788	2560	52	None	15	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
	73755154	2560	52	None	15	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
	CHEMBL1086657	2560	52	None	15	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
	70683908	75040	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	280	4	2	4	1.0	O=c1[nH]c(=O)c2c(CCCC3(F)CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2035002	75040	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	280	4	2	4	1.0	O=c1[nH]c(=O)c2c(CCCC3(F)CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	59343651	75263	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	290	5	2	4	1.7	CCC1(CCCc2cc(=O)oc3[nH]c(=O)[nH]c(=O)c23)CC1	10.1021/ml200243g
	CHEMBL2036959	75263	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	290	5	2	4	1.7	CCC1(CCCc2cc(=O)oc3[nH]c(=O)[nH]c(=O)c23)CC1	10.1021/ml200243g
	57413367	76113	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	178	1	2	2	1.0	C[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	CHEMBL2057614	76113	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	178	1	2	2	1.0	C[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	137635325	156149	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	313	4	3	3	2.6	O=C(CCC#Cc1ccc(O)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4063682	156149	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	313	4	3	3	2.6	O=C(CCC#Cc1ccc(O)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	11322738	136766	1	None	13	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	252	2	1	3	2.1	CC1(c2cccc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL374111	136766	1	None	13	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	252	2	1	3	2.1	CC1(c2cccc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	136375410	177317	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	370	7	3	7	2.5	CCn1cc(NC(=O)CCc2nc(-c3ccc(O)cc3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
	CHEMBL4636989	177317	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	370	7	3	7	2.5	CCn1cc(NC(=O)CCc2nc(-c3ccc(O)cc3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
	16048770	94631	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	377	3	2	5	2.7	O=C(O)c1ccccc1NC(=O)N1CCN(c2cnc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
	CHEMBL252306	94631	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	377	3	2	5	2.7	O=C(O)c1ccccc1NC(=O)N1CCN(c2cnc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
	59304808	75237	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	262	1	2	4	0.3	O=c1[nH]c(=O)c2c(CC(F)(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036816	75237	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	262	1	2	4	0.3	O=c1[nH]c(=O)c2c(CC(F)(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	135800177	145951	7	None	-24	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assayAgonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assay	ChEMBL	353	6	3	6	2.7	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	CHEMBL391813	145951	7	None	-24	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assayAgonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assay	ChEMBL	353	6	3	6	2.7	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	135899325	16193	0	None	-1	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat GPR109A receptor assessed as GTPgammaS bindingAgonist activity at rat GPR109A receptor assessed as GTPgammaS binding	ChEMBL	299	5	1	4	2.2	O=c1[nH]c(COCCc2ccc(F)cc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	CHEMBL1224147	16193	0	None	-1	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat GPR109A receptor assessed as GTPgammaS bindingAgonist activity at rat GPR109A receptor assessed as GTPgammaS binding	ChEMBL	299	5	1	4	2.2	O=c1[nH]c(COCCc2ccc(F)cc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	1592	144	131	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	137	1	1	2	1.1	Cc1cc(cnc1)C(=O)O	10.1016/j.bmcl.2007.06.028
	256208	144	131	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	137	1	1	2	1.1	Cc1cc(cnc1)C(=O)O	10.1016/j.bmcl.2007.06.028
	CHEMBL247132	144	131	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	137	1	1	2	1.1	Cc1cc(cnc1)C(=O)O	10.1016/j.bmcl.2007.06.028
	44441302	93355	23	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	166	2	2	2	1.4	O=C(O)c1cc(C2CCC2)n[nH]1	10.1016/j.bmcl.2007.06.028
	CHEMBL245491	93355	23	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	166	2	2	2	1.4	O=C(O)c1cc(C2CCC2)n[nH]1	10.1016/j.bmcl.2007.06.028
	57412217	76348	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	206	3	2	2	1.8	CCC[C@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@H]12	10.1021/jm2010964
	CHEMBL2059223	76348	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	206	3	2	2	1.8	CCC[C@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@H]12	10.1021/jm2010964
	11159621	2548	46	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity against human GPR109a assessed as forskolin-induced cAMP accumulationAgonist activity against human GPR109a assessed as forskolin-induced cAMP accumulation	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	5784	2548	46	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity against human GPR109a assessed as forskolin-induced cAMP accumulationAgonist activity against human GPR109a assessed as forskolin-induced cAMP accumulation	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	CHEMBL456145	2548	46	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity against human GPR109a assessed as forskolin-induced cAMP accumulationAgonist activity against human GPR109a assessed as forskolin-induced cAMP accumulation	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	DB05939	2548	46	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity against human GPR109a assessed as forskolin-induced cAMP accumulationAgonist activity against human GPR109a assessed as forskolin-induced cAMP accumulation	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	145957566	162287	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	426	3	1	5	5.0	COc1ccc(-c2cc3cc(C4Nc5ccccc5C(=O)N4C)cc(C)c3oc2=O)cc1	10.1016/j.ejmech.2018.04.037
	CHEMBL4164140	162287	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	426	3	1	5	5.0	COc1ccc(-c2cc3cc(C4Nc5ccccc5C(=O)N4C)cc(C)c3oc2=O)cc1	10.1016/j.ejmech.2018.04.037
	145957566	162287	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	426	3	1	5	5.0	COc1ccc(-c2cc3cc(C4Nc5ccccc5C(=O)N4C)cc(C)c3oc2=O)cc1	10.1016/j.ejmech.2018.04.037
	CHEMBL4164140	162287	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	426	3	1	5	5.0	COc1ccc(-c2cc3cc(C4Nc5ccccc5C(=O)N4C)cc(C)c3oc2=O)cc1	10.1016/j.ejmech.2018.04.037
	21660892	147518	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	136	1	2	4	-0.4	c1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL393063	147518	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	136	1	2	4	-0.4	c1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	136086823	6969	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	400	8	3	7	2.8	CCCC1CCC(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
	CHEMBL1084576	6969	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	400	8	3	7	2.8	CCCC1CCC(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
	15605571	75235	2	None	-3	5	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	236	3	2	4	0.5	CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036813	75235	2	None	-3	5	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	236	3	2	4	0.5	CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	117629482	2823	140	None	-4	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR109A (unknown origin) assessed as inhibition of forskolin-mediated cAMP accumulation after 15 mins by fluorescence assayAgonist activity at GPR109A (unknown origin) assessed as inhibition of forskolin-mediated cAMP accumulation after 15 mins by fluorescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/acs.jmedchem.8b00435
	1588	2823	140	None	-4	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR109A (unknown origin) assessed as inhibition of forskolin-mediated cAMP accumulation after 15 mins by fluorescence assayAgonist activity at GPR109A (unknown origin) assessed as inhibition of forskolin-mediated cAMP accumulation after 15 mins by fluorescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/acs.jmedchem.8b00435
	1594	2823	140	None	-4	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR109A (unknown origin) assessed as inhibition of forskolin-mediated cAMP accumulation after 15 mins by fluorescence assayAgonist activity at GPR109A (unknown origin) assessed as inhibition of forskolin-mediated cAMP accumulation after 15 mins by fluorescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/acs.jmedchem.8b00435
	2835	2823	140	None	-4	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR109A (unknown origin) assessed as inhibition of forskolin-mediated cAMP accumulation after 15 mins by fluorescence assayAgonist activity at GPR109A (unknown origin) assessed as inhibition of forskolin-mediated cAMP accumulation after 15 mins by fluorescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/acs.jmedchem.8b00435
	938	2823	140	None	-4	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR109A (unknown origin) assessed as inhibition of forskolin-mediated cAMP accumulation after 15 mins by fluorescence assayAgonist activity at GPR109A (unknown origin) assessed as inhibition of forskolin-mediated cAMP accumulation after 15 mins by fluorescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/acs.jmedchem.8b00435
	CHEMBL573	2823	140	None	-4	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR109A (unknown origin) assessed as inhibition of forskolin-mediated cAMP accumulation after 15 mins by fluorescence assayAgonist activity at GPR109A (unknown origin) assessed as inhibition of forskolin-mediated cAMP accumulation after 15 mins by fluorescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/acs.jmedchem.8b00435
	DB00627	2823	140	None	-4	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR109A (unknown origin) assessed as inhibition of forskolin-mediated cAMP accumulation after 15 mins by fluorescence assayAgonist activity at GPR109A (unknown origin) assessed as inhibition of forskolin-mediated cAMP accumulation after 15 mins by fluorescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/acs.jmedchem.8b00435
	135399731	184157	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	391	5	3	5	3.2	Cn1nc2c(c1CCC(=O)Nc1ccccc1C(=O)O)CCc1cc(O)ccc1-2	10.1021/jm900151e
	CHEMBL482963	184157	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	391	5	3	5	3.2	Cn1nc2c(c1CCC(=O)Nc1ccccc1C(=O)O)CCc1cc(O)ccc1-2	10.1021/jm900151e
	70681781	75239	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	288	2	2	4	0.9	O=c1[nH]c(=O)c2c(Cc3ccc(F)cc3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036820	75239	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	288	2	2	4	0.9	O=c1[nH]c(=O)c2c(Cc3ccc(F)cc3)cc(=O)oc2[nH]1	10.1021/ml200243g
	136127010	16086	11	None	-9	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109A receptor assessed as GTPgammaS bindingAgonist activity at human GPR109A receptor assessed as GTPgammaS binding	ChEMBL	215	0	1	3	1.3	O=c1[nH]c(C(F)(F)F)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	CHEMBL1223819	16086	11	None	-9	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109A receptor assessed as GTPgammaS bindingAgonist activity at human GPR109A receptor assessed as GTPgammaS binding	ChEMBL	215	0	1	3	1.3	O=c1[nH]c(C(F)(F)F)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	16048843	154391	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	392	3	3	6	2.3	Nc1ccc2nc(N3CCN(C(=O)Nc4ccccc4C(=O)O)CC3)cnc2c1	10.1016/j.bmcl.2007.10.055
	CHEMBL398762	154391	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	392	3	3	6	2.3	Nc1ccc2nc(N3CCN(C(=O)Nc4ccccc4C(=O)O)CC3)cnc2c1	10.1016/j.bmcl.2007.10.055
	24953857	69951	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	342	5	1	5	2.8	CCC#CCOc1nc2oc(=O)cc(CCC3CCCC3)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939046	69951	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	342	5	1	5	2.8	CCC#CCOc1nc2oc(=O)cc(CCC3CCCC3)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	57400598	69945	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	328	3	1	5	2.4	CCc1cc(=O)oc2nc(OCC#CC3CCCCC3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939040	69945	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	328	3	1	5	2.4	CCc1cc(=O)oc2nc(OCC#CC3CCCCC3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	57413446	76347	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	206	3	2	2	1.8	CCC[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	CHEMBL2059222	76347	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	206	3	2	2	1.8	CCC[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	24954572	69947	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	290	4	2	6	0.2	CCc1cc(=O)oc2nc(OCC#CCCO)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939042	69947	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	290	4	2	6	0.2	CCc1cc(=O)oc2nc(OCC#CCCO)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	44579646	186965	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	432	7	1	5	4.8	Cc1c(C(=O)NCCOc2ccccc2F)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
	CHEMBL490413	186965	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	432	7	1	5	4.8	Cc1c(C(=O)NCCOc2ccccc2F)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
	13153555	93863	27	None	42	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	182	5	2	2	1.8	CCCCCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.06.028
	CHEMBL247921	93863	27	None	42	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	182	5	2	2	1.8	CCCCCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.06.028
	676464	89876	75	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	154	3	2	2	1.1	CCCc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL237788	89876	75	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	154	3	2	2	1.1	CCCc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.07.101
	44433529	88536	0	None	-5	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	CHEMBL235230	88536	0	None	-5	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	46889397	6725	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	232	3	2	5	0.1	COC[C@@H]1[C@H]2Cc3c(-c4nnn[nH]4)n[nH]c3[C@H]21	10.1016/j.bmcl.2010.03.062
	CHEMBL1083688	6725	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	232	3	2	5	0.1	COC[C@@H]1[C@H]2Cc3c(-c4nnn[nH]4)n[nH]c3[C@H]21	10.1016/j.bmcl.2010.03.062
	44433530	147524	0	None	-2	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	192	4	2	4	0.9	CCCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL393065	147524	0	None	-2	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	192	4	2	4	0.9	CCCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	135416384	184824	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	382	5	3	5	3.1	O=C(CCc1noc2c1CCc1cc(O)ccc1-2)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
	CHEMBL485196	184824	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	382	5	3	5	3.1	O=C(CCc1noc2c1CCc1cc(O)ccc1-2)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
	15605645	75244	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	250	4	2	4	0.9	CCCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036825	75244	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	250	4	2	4	0.9	CCCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	57397199	69919	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	298	4	1	5	2.0	CCc1cc(=O)oc2nc(OCc3ccccc3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939014	69919	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	298	4	1	5	2.0	CCc1cc(=O)oc2nc(OCc3ccccc3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	135899171	16170	0	None	-18	3	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat GPR109A receptor assessed as GTPgammaS bindingAgonist activity at rat GPR109A receptor assessed as GTPgammaS binding	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	CHEMBL1224070	16170	0	None	-18	3	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat GPR109A receptor assessed as GTPgammaS bindingAgonist activity at rat GPR109A receptor assessed as GTPgammaS binding	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	137661636	159263	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	331	4	2	2	3.5	O=C(CCC#Cc1ccccc1Cl)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4099238	159263	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	331	4	2	2	3.5	O=C(CCC#Cc1ccccc1Cl)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	137662135	159350	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	367	6	2	2	4.5	O=C(CCc1ccc(-c2ccccc2F)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4100231	159350	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	367	6	2	2	4.5	O=C(CCc1ccc(-c2ccccc2F)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	44579779	186895	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	428	7	1	5	4.9	COCC(NC(=O)c1cnc2c(-c3ccc(C(C)C)cc3)cnn2c1C)c1ccccc1	10.1016/j.bmcl.2008.08.039
	CHEMBL489787	186895	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	428	7	1	5	4.9	COCC(NC(=O)c1cnc2c(-c3ccc(C(C)C)cc3)cnn2c1C)c1ccccc1	10.1016/j.bmcl.2008.08.039
	15986755	184118	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	339	5	3	3	3.5	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	CHEMBL482698	184118	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	339	5	3	3	3.5	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	16125020	137618	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	230	1	1	3	1.4	O=C(O)C1=CC(=O)C2(CCc3ccccc32)O1	10.1021/jm070022x
	CHEMBL375753	137618	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	230	1	1	3	1.4	O=C(O)C1=CC(=O)C2(CCc3ccccc32)O1	10.1021/jm070022x
	57413546	76111	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	222	4	2	3	1.0	CCOC[C@H]1[C@H]2c3[nH]nc(C(=O)O)c3C[C@H]21	10.1021/jm2010964
	CHEMBL2057607	76111	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	222	4	2	3	1.0	CCOC[C@H]1[C@H]2c3[nH]nc(C(=O)O)c3C[C@H]21	10.1021/jm2010964
	137645601	157851	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	299	6	2	2	3.2	O=C(/C=C/CCc1ccccc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4083723	157851	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	299	6	2	2	3.2	O=C(/C=C/CCc1ccccc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	57413542	76476	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	204	2	2	2	1.4	O=C(O)c1n[nH]c2c1C[C@@H]1[C@H]2[C@@H]1C1CC1	10.1021/jm2010964
	CHEMBL2059829	76476	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	204	2	2	2	1.4	O=C(O)c1n[nH]c2c1C[C@@H]1[C@H]2[C@@H]1C1CC1	10.1021/jm2010964
	56950369	3559	13	None	3	4	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	8469	3559	13	None	3	4	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	CHEMBL2036958	3559	13	None	3	4	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	DB12433	3559	13	None	3	4	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	59343664	75256	0	None	1	4	Rat	8.7	pEC50	=	8.7	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	272	4	2	4	0.8	O=c1[nH]c(=O)c2c(CCCC(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036951	75256	0	None	1	4	Rat	8.7	pEC50	=	8.7	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	272	4	2	4	0.8	O=c1[nH]c(=O)c2c(CCCC(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	15604637	75260	0	None	1	3	Rat	8.7	pEC50	=	8.7	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	262	4	2	4	0.9	O=c1[nH]c(=O)c2c(CCCC3CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036955	75260	0	None	1	3	Rat	8.7	pEC50	=	8.7	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	262	4	2	4	0.9	O=c1[nH]c(=O)c2c(CCCC3CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	117629482	2823	140	None	-4	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	1588	2823	140	None	-4	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	1594	2823	140	None	-4	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	2835	2823	140	None	-4	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	938	2823	140	None	-4	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	CHEMBL573	2823	140	None	-4	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	DB00627	2823	140	None	-4	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	117629482	2823	140	None	-4	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	1588	2823	140	None	-4	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	1594	2823	140	None	-4	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	2835	2823	140	None	-4	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	938	2823	140	None	-4	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	CHEMBL573	2823	140	None	-4	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	DB00627	2823	140	None	-4	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	11379903	84271	0	None	6	2	Human	6.7	pEC50	=	6.7	Functional	Activity at GPR109a assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109a assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm800896z
	CHEMBL221282	84271	0	None	6	2	Human	6.7	pEC50	=	6.7	Functional	Activity at GPR109a assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109a assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm800896z
	11379903	84271	0	None	6	2	Human	6.7	pEC50	=	6.7	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL221282	84271	0	None	6	2	Human	6.7	pEC50	=	6.7	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	11206816	84907	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	222	2	1	3	1.8	CC1(C2=CCCCC2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL223706	84907	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	222	2	1	3	1.8	CC1(C2=CCCCC2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	136375465	177133	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	357	6	3	8	1.4	Cn1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
	CHEMBL4633857	177133	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	357	6	3	8	1.4	Cn1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
	46889399	6833	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	242	1	2	4	1.4	C1CCC2(C1)[C@H]1Cc3c(-c4nnn[nH]4)n[nH]c3[C@H]12	10.1016/j.bmcl.2010.03.062
	CHEMBL1083990	6833	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	242	1	2	4	1.4	C1CCC2(C1)[C@H]1Cc3c(-c4nnn[nH]4)n[nH]c3[C@H]12	10.1016/j.bmcl.2010.03.062
	28400056	152223	1	None	-74	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR109a receptor transfected in CHOK1 cells assessed as reversal of forskolin induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109a receptor transfected in CHOK1 cells assessed as reversal of forskolin induced cAMP elevating effect by whole cell assay	ChEMBL	208	5	2	3	2.4	CCC(CC)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL396879	152223	1	None	-74	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR109a receptor transfected in CHOK1 cells assessed as reversal of forskolin induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109a receptor transfected in CHOK1 cells assessed as reversal of forskolin induced cAMP elevating effect by whole cell assay	ChEMBL	208	5	2	3	2.4	CCC(CC)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	57398904	69922	1	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	280	6	1	6	0.9	CCOCCOc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939017	69922	1	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	280	6	1	6	0.9	CCOCCOc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	135416388	7524	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	358	6	3	7	1.8	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
	CHEMBL1087302	7524	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	358	6	3	7	1.8	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
	135416388	7524	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	358	6	3	7	1.8	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1087302	7524	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	358	6	3	7	1.8	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.001
	11672811	1001	5	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	188	1	2	4	0.2	n1nnc([nH]1)c1n[nH]c2c1CC1C2C1	10.1016/j.bmcl.2010.03.062
	5790	1001	5	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	188	1	2	4	0.2	n1nnc([nH]1)c1n[nH]c2c1CC1C2C1	10.1016/j.bmcl.2010.03.062
	CHEMBL1169573	1001	5	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	188	1	2	4	0.2	n1nnc([nH]1)c1n[nH]c2c1CC1C2C1	10.1016/j.bmcl.2010.03.062
	11311474	165782	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2ccc(Cl)s2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL424750	165782	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2ccc(Cl)s2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	24741306	166956	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	334	6	3	2	4.0	O=C(CCc1ccc(-c2ccc[nH]2)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	CHEMBL428724	166956	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	334	6	3	2	4.0	O=C(CCc1ccc(-c2ccc[nH]2)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	44579761	187158	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	428	7	1	5	4.9	Cc1ccc(OCCNC(=O)c2cnc3c(-c4ccc(C(C)C)cc4)cnn3c2C)cc1	10.1016/j.bmcl.2008.08.039
	CHEMBL492019	187158	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	428	7	1	5	4.9	Cc1ccc(OCCNC(=O)c2cnc3c(-c4ccc(C(C)C)cc4)cnn3c2C)cc1	10.1016/j.bmcl.2008.08.039
	44441322	147563	1	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	196	3	2	3	1.5	CCCC1OCc2c1n[nH]c2C(=O)O	10.1016/j.bmcl.2007.06.028
	CHEMBL393086	147563	1	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	196	3	2	3	1.5	CCCC1OCc2c1n[nH]c2C(=O)O	10.1016/j.bmcl.2007.06.028
	145985690	165443	0	None	-17	3	Rat	5.7	pEC50	=	5.7	Functional	Agonist activity at rat GPR109A expressed in T-REx-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin stimulation and measured after 20 mins by TR-FRET assayAgonist activity at rat GPR109A expressed in T-REx-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin stimulation and measured after 20 mins by TR-FRET assay	ChEMBL	464	5	2	7	3.9	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3c(s2)CCCC3)cc1N1CCOCC1	10.1021/acs.jmedchem.7b00718
	CHEMBL4239086	165443	0	None	-17	3	Rat	5.7	pEC50	=	5.7	Functional	Agonist activity at rat GPR109A expressed in T-REx-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin stimulation and measured after 20 mins by TR-FRET assayAgonist activity at rat GPR109A expressed in T-REx-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin stimulation and measured after 20 mins by TR-FRET assay	ChEMBL	464	5	2	7	3.9	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3c(s2)CCCC3)cc1N1CCOCC1	10.1021/acs.jmedchem.7b00718
	57412211	76116	1	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	178	1	2	2	1.0	C[C@H]1[C@@H]2c3[nH]nc(C(=O)O)c3C[C@@H]21	10.1021/jm2010964
	CHEMBL2057617	76116	1	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	178	1	2	2	1.0	C[C@H]1[C@@H]2c3[nH]nc(C(=O)O)c3C[C@@H]21	10.1021/jm2010964
	53238781	1027	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	389	6	3	7	1.4	C[C@@H]1CCC(=C(C1)NC(=O)[C@H](Cc1onc(n1)c1ccc(cn1)F)N)C(=O)O	10.1016/j.bmcl.2010.11.116
	5789	1027	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	389	6	3	7	1.4	C[C@@H]1CCC(=C(C1)NC(=O)[C@H](Cc1onc(n1)c1ccc(cn1)F)N)C(=O)O	10.1016/j.bmcl.2010.11.116
	CHEMBL1770358	1027	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	389	6	3	7	1.4	C[C@@H]1CCC(=C(C1)NC(=O)[C@H](Cc1onc(n1)c1ccc(cn1)F)N)C(=O)O	10.1016/j.bmcl.2010.11.116
	135416392	7437	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	372	6	3	7	2.0	CC(Cc1nc(-c2ccc(O)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
	CHEMBL1086656	7437	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	372	6	3	7	2.0	CC(Cc1nc(-c2ccc(O)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
	24953854	69952	0	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	328	5	1	5	2.4	CCC#CCOc1nc2oc(=O)cc(CCC3CCC3)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939047	69952	0	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	328	5	1	5	2.4	CCC#CCOc1nc2oc(=O)cc(CCC3CCC3)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	46890539	7040	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	472	7	2	6	3.9	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1084841	7040	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	472	7	2	6	3.9	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
	57412216	76118	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	192	2	2	2	1.4	CC[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	CHEMBL2057619	76118	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	192	2	2	2	1.4	CC[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	59304931	75236	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	222	1	2	4	0.3	CC(C)c1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036814	75236	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	222	1	2	4	0.3	CC(C)c1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	44441326	150178	5	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	170	1	2	3	0.8	O=C(O)c1[nH]nc2c1SCC2	10.1016/j.bmcl.2007.06.028
	CHEMBL395177	150178	5	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	170	1	2	3	0.8	O=C(O)c1[nH]nc2c1SCC2	10.1016/j.bmcl.2007.06.028
	16048921	155017	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	366	3	2	5	2.9	O=C(O)c1ccccc1NC(=O)N1CCN(c2nc3ccccc3o2)CC1	10.1016/j.bmcl.2007.10.055
	CHEMBL401470	155017	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	366	3	2	5	2.9	O=C(O)c1ccccc1NC(=O)N1CCN(c2nc3ccccc3o2)CC1	10.1016/j.bmcl.2007.10.055
	44441302	93355	23	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	166	2	2	2	1.4	O=C(O)c1cc(C2CCC2)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL245491	93355	23	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	166	2	2	2	1.4	O=C(O)c1cc(C2CCC2)n[nH]1	10.1016/j.bmcl.2007.07.101
	57413447	76349	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	220	4	2	2	2.2	CCCC[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	CHEMBL2059224	76349	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	220	4	2	2	2.2	CCCC[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	57412300	76475	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	204	3	2	2	1.6	C=CC[C@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@H]12	10.1021/jm2010964
	CHEMBL2059828	76475	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	204	3	2	2	1.6	C=CC[C@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@H]12	10.1021/jm2010964
	46890537	7038	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	454	7	2	6	3.8	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CC(c2cccc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1084839	7038	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	454	7	2	6	3.8	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CC(c2cccc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
	59304949	75249	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	250	3	2	4	1.1	CCCC(C)c1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036830	75249	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	250	3	2	4	1.1	CCCC(C)c1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	137647495	157856	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	365	6	3	3	4.0	O=C(CCc1ccc(-c2cccc(O)c2)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4083762	157856	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	365	6	3	3	4.0	O=C(CCc1ccc(-c2cccc(O)c2)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	11159621	2548	46	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity against human GPR109a assessed as GTPgammaS bindingAgonist activity against human GPR109a assessed as GTPgammaS binding	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	5784	2548	46	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity against human GPR109a assessed as GTPgammaS bindingAgonist activity against human GPR109a assessed as GTPgammaS binding	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	CHEMBL456145	2548	46	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity against human GPR109a assessed as GTPgammaS bindingAgonist activity against human GPR109a assessed as GTPgammaS binding	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	DB05939	2548	46	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity against human GPR109a assessed as GTPgammaS bindingAgonist activity against human GPR109a assessed as GTPgammaS binding	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	11159621	2548	46	None	-2	3	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity against rat GPR109a assessed as GTPgammaS bindingAgonist activity against rat GPR109a assessed as GTPgammaS binding	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	5784	2548	46	None	-2	3	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity against rat GPR109a assessed as GTPgammaS bindingAgonist activity against rat GPR109a assessed as GTPgammaS binding	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	CHEMBL456145	2548	46	None	-2	3	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity against rat GPR109a assessed as GTPgammaS bindingAgonist activity against rat GPR109a assessed as GTPgammaS binding	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	DB05939	2548	46	None	-2	3	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity against rat GPR109a assessed as GTPgammaS bindingAgonist activity against rat GPR109a assessed as GTPgammaS binding	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	44579648	186966	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	448	7	1	5	5.3	Cc1c(C(=O)NCCOc2ccc(Cl)cc2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
	CHEMBL490414	186966	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	448	7	1	5	5.3	Cc1c(C(=O)NCCOc2ccc(Cl)cc2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
	44580036	187101	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	464	7	1	5	5.8	Cc1c(C(=O)NCCOc2ccc3ccccc3c2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
	CHEMBL491439	187101	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	464	7	1	5	5.8	Cc1c(C(=O)NCCOc2ccc3ccccc3c2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
	12003791	194829	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
	CHEMBL1237147	194829	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
	CHEMBL539398	194829	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
	11390981	136550	1	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	248	3	1	4	1.5	COc1cccc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	CHEMBL373752	136550	1	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	248	3	1	4	1.5	COc1cccc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	2761046	148783	125	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	124	1	1	3	0.2	O=C(O)c1ccnnc1	10.1016/j.bmcl.2007.06.028
	CHEMBL394068	148783	125	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	124	1	1	3	0.2	O=C(O)c1ccnnc1	10.1016/j.bmcl.2007.06.028
	46889362	7184	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	244	3	2	4	1.5	CC(C)C[C@H]1C2Cc3c(-c4nnn[nH]4)n[nH]c3[C@H]21	10.1016/j.bmcl.2010.03.062
	CHEMBL1085538	7184	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	244	3	2	4	1.5	CC(C)C[C@H]1C2Cc3c(-c4nnn[nH]4)n[nH]c3[C@H]21	10.1016/j.bmcl.2010.03.062
	145949989	162960	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	410	2	1	4	5.3	Cc1ccc(-c2cc3cc(C4Nc5ccccc5C(=O)N4C)cc(C)c3oc2=O)cc1	10.1016/j.ejmech.2018.04.037
	CHEMBL4174798	162960	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	410	2	1	4	5.3	Cc1ccc(-c2cc3cc(C4Nc5ccccc5C(=O)N4C)cc(C)c3oc2=O)cc1	10.1016/j.ejmech.2018.04.037
	145949989	162960	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	410	2	1	4	5.3	Cc1ccc(-c2cc3cc(C4Nc5ccccc5C(=O)N4C)cc(C)c3oc2=O)cc1	10.1016/j.ejmech.2018.04.037
	CHEMBL4174798	162960	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	410	2	1	4	5.3	Cc1ccc(-c2cc3cc(C4Nc5ccccc5C(=O)N4C)cc(C)c3oc2=O)cc1	10.1016/j.ejmech.2018.04.037
	46889320	6654	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	202	1	2	4	0.5	C[C@@H]1[C@@H]2c3[nH]nc(-c4nnn[nH]4)c3C[C@H]12	10.1016/j.bmcl.2010.03.062
	CHEMBL1083380	6654	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	202	1	2	4	0.5	C[C@@H]1[C@@H]2c3[nH]nc(-c4nnn[nH]4)c3C[C@H]12	10.1016/j.bmcl.2010.03.062
	57390148	69932	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	399	5	1	6	3.6	CCc1cc(=O)oc2nc(OCc3ccccc3-c3cccc(C#N)c3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939027	69932	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	399	5	1	6	3.6	CCc1cc(=O)oc2nc(OCc3ccccc3-c3cccc(C#N)c3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	42625218	184179	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	398	5	3	5	3.8	O=C(CCc1noc2c1ccc1c(F)c(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
	CHEMBL483140	184179	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	398	5	3	5	3.8	O=C(CCc1noc2c1ccc1c(F)c(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
	135416388	7524	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	358	6	3	7	1.8	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.11.116
	CHEMBL1087302	7524	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	358	6	3	7	1.8	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.11.116
	9822	145638	133	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	126	1	2	2	0.4	Cc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL391574	145638	133	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	126	1	2	2	0.4	Cc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.07.101
	11436345	143	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1599	143	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL424938	143	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	24741312	89399	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	358	6	3	7	2.3	O=C(CCc1cnc(-n2cc(O)cn2)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	CHEMBL237036	89399	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	358	6	3	7	2.3	O=C(CCc1cnc(-n2cc(O)cn2)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	135416394	2560	52	None	-15	3	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR109A receptor by [35S]GTPgammaS binding assayAgonist activity at mouse GPR109A receptor by [35S]GTPgammaS binding assay	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
	5788	2560	52	None	-15	3	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR109A receptor by [35S]GTPgammaS binding assayAgonist activity at mouse GPR109A receptor by [35S]GTPgammaS binding assay	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
	73755154	2560	52	None	-15	3	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR109A receptor by [35S]GTPgammaS binding assayAgonist activity at mouse GPR109A receptor by [35S]GTPgammaS binding assay	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
	CHEMBL1086657	2560	52	None	-15	3	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR109A receptor by [35S]GTPgammaS binding assayAgonist activity at mouse GPR109A receptor by [35S]GTPgammaS binding assay	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
	11183678	84772	1	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	224	2	1	4	1.5	CC1(c2ccsc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL223140	84772	1	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	224	2	1	4	1.5	CC1(c2ccsc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	11148966	1122	4	None	-4	2	Human	4.6	pEC50	=	4.6	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	10.1021/jm070022x
	1598	1122	4	None	-4	2	Human	4.6	pEC50	=	4.6	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	10.1021/jm070022x
	CHEMBL436301	1122	4	None	-4	2	Human	4.6	pEC50	=	4.6	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	10.1021/jm070022x
	46889336	7064	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	202	1	2	4	0.5	C[C@H]1[C@@H]2c3[nH]nc(-c4nnn[nH]4)c3C[C@@H]21	10.1016/j.bmcl.2010.03.062
	CHEMBL1084950	7064	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	202	1	2	4	0.5	C[C@H]1[C@@H]2c3[nH]nc(-c4nnn[nH]4)c3C[C@@H]21	10.1016/j.bmcl.2010.03.062
	24955288	58055	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	270	4	1	4	2.2	CCCCc1cc(=O)oc2nc(C(F)F)[nH]c(=O)c12	10.1021/ml100251u
	CHEMBL1672750	58055	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	270	4	1	4	2.2	CCCCc1cc(=O)oc2nc(C(F)F)[nH]c(=O)c12	10.1021/ml100251u
	46889363	7185	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	244	3	2	4	1.5	CC(C)C[C@H]1[C@@H]2c3[nH]nc(-c4nnn[nH]4)c3C[C@@H]21	10.1016/j.bmcl.2010.03.062
	CHEMBL1085539	7185	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	244	3	2	4	1.5	CC(C)C[C@H]1[C@@H]2c3[nH]nc(-c4nnn[nH]4)c3C[C@@H]21	10.1016/j.bmcl.2010.03.062
	57412302	76108	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	208	3	2	3	0.6	COC[C@@H]1[C@H]2c3[nH]nc(C(=O)O)c3C[C@@H]12	10.1021/jm2010964
	CHEMBL2057604	76108	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	208	3	2	3	0.6	COC[C@@H]1[C@H]2c3[nH]nc(C(=O)O)c3C[C@@H]12	10.1021/jm2010964
	135416392	7437	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	372	6	3	7	2.0	CC(Cc1nc(-c2ccc(O)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
	CHEMBL1086656	7437	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	372	6	3	7	2.0	CC(Cc1nc(-c2ccc(O)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
	46890538	7039	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	469	7	3	7	2.7	NC(Cc1nc(-c2ccc(F)cn2)no1)C(=O)NC1=C(C(=O)O)CC(c2cccc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1084840	7039	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	469	7	3	7	2.7	NC(Cc1nc(-c2ccc(F)cn2)no1)C(=O)NC1=C(C(=O)O)CC(c2cccc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
	137632012	156656	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	311	3	3	3	2.3	O=C(/C=C/C#Cc1ccccc1O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4069406	156656	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	311	3	3	3	2.3	O=C(/C=C/C#Cc1ccccc1O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	11413114	137619	0	None	2	2	Human	5.6	pEC50	=	5.6	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	208	2	1	3	1.4	CC1(C2=CCCC2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL375754	137619	0	None	2	2	Human	5.6	pEC50	=	5.6	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	208	2	1	3	1.4	CC1(C2=CCCC2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	135899325	16193	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109A receptor assessed as GTPgammaS bindingAgonist activity at human GPR109A receptor assessed as GTPgammaS binding	ChEMBL	299	5	1	4	2.2	O=c1[nH]c(COCCc2ccc(F)cc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	CHEMBL1224147	16193	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109A receptor assessed as GTPgammaS bindingAgonist activity at human GPR109A receptor assessed as GTPgammaS binding	ChEMBL	299	5	1	4	2.2	O=c1[nH]c(COCCc2ccc(F)cc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	44441311	93667	49	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	142	2	3	3	-0.4	O=C(O)c1cc(CO)n[nH]1	10.1016/j.bmcl.2007.06.028
	CHEMBL246903	93667	49	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	142	2	3	3	-0.4	O=C(O)c1cc(CO)n[nH]1	10.1016/j.bmcl.2007.06.028
	44441320	147562	2	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	168	1	2	3	0.7	CC1OCc2c1n[nH]c2C(=O)O	10.1016/j.bmcl.2007.06.028
	CHEMBL393085	147562	2	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	168	1	2	3	0.7	CC1OCc2c1n[nH]c2C(=O)O	10.1016/j.bmcl.2007.06.028
	12003790	196055	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	276	2	2	2	3.0	O=C(O)c1n[nH]c2c1CC(c1ccccc1Cl)CC2	10.1016/j.bmcl.2009.06.054
	CHEMBL560406	196055	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	276	2	2	2	3.0	O=C(O)c1n[nH]c2c1CC(c1ccccc1Cl)CC2	10.1016/j.bmcl.2009.06.054
	17688981	147517	46	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	160	1	2	2	1.1	Cc1[nH]nc(C(=O)O)c1Cl	10.1016/j.bmcl.2007.07.101
	CHEMBL393062	147517	46	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	160	1	2	2	1.1	Cc1[nH]nc(C(=O)O)c1Cl	10.1016/j.bmcl.2007.07.101
	57400599	69948	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	304	5	2	6	0.6	CCc1cc(=O)oc2nc(OCC#CCCCO)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939043	69948	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	304	5	2	6	0.6	CCc1cc(=O)oc2nc(OCC#CCCCO)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	15604644	75242	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	304	4	2	5	1.4	O=c1[nH]c(=O)c2c(CCCc3cccs3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036823	75242	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	304	4	2	5	1.4	O=c1[nH]c(=O)c2c(CCCc3cccs3)cc(=O)oc2[nH]1	10.1021/ml200243g
	117629482	2823	140	None	-4	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.05.108
	1588	2823	140	None	-4	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.05.108
	1594	2823	140	None	-4	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.05.108
	2835	2823	140	None	-4	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.05.108
	938	2823	140	None	-4	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.05.108
	CHEMBL573	2823	140	None	-4	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.05.108
	DB00627	2823	140	None	-4	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.05.108
	57393656	69925	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	264	4	1	5	1.5	COc1nc2oc(=O)cc(CCC(C)C)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939020	69925	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	264	4	1	5	1.5	COc1nc2oc(=O)cc(CCC(C)C)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	137637662	156241	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	383	6	3	3	4.2	O=C(CCc1ccc(-c2ccc(O)cc2F)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4064786	156241	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	383	6	3	3	4.2	O=C(CCc1ccc(-c2ccc(O)cc2F)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	11817645	84906	1	None	12	2	Human	5.6	pEC50	=	5.6	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2cc(F)cc(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL223700	84906	1	None	12	2	Human	5.6	pEC50	=	5.6	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2cc(F)cc(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	42625382	184812	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	416	5	3	5	3.7	Cn1c(=O)c2cc(O)ccc2c2ccc(CCC(=O)Nc3ccccc3C(=O)O)cc21	10.1021/jm900151e
	CHEMBL485184	184812	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	416	5	3	5	3.7	Cn1c(=O)c2cc(O)ccc2c2ccc(CCC(=O)Nc3ccccc3C(=O)O)cc21	10.1021/jm900151e
	156012920	177449	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	433	8	3	8	3.0	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1cn(Cc2ccncc2)cc1C(=O)O	10.1016/j.bmcl.2020.127105
	CHEMBL4638809	177449	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	433	8	3	8	3.0	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1cn(Cc2ccncc2)cc1C(=O)O	10.1016/j.bmcl.2020.127105
	90645412	112415	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	365	6	2	4	3.4	COc1ccc(/C=C/C(=O)NC2=C(C(=O)O)CCCC2)c(Cl)c1OC	10.1016/j.bmc.2014.05.011
	CHEMBL3297797	112415	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	365	6	2	4	3.4	COc1ccc(/C=C/C(=O)NC2=C(C(=O)O)CCCC2)c(Cl)c1OC	10.1016/j.bmc.2014.05.011
	46890400	7286	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	419	6	3	5	3.6	Cn1cc(C2CCC(NC(=O)CCc3ccc4cc(O)ccc4c3)=C(C(=O)O)C2)cn1	10.1016/j.bmcl.2010.04.001
	CHEMBL1086030	7286	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	419	6	3	5	3.6	Cn1cc(C2CCC(NC(=O)CCc3ccc4cc(O)ccc4c3)=C(C(=O)O)C2)cn1	10.1016/j.bmcl.2010.04.001
	44433525	147255	24	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	170	2	2	2	1.1	O=C(O)c1n[nH]c(C2CC2)c1F	10.1016/j.bmcl.2007.07.101
	CHEMBL392859	147255	24	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	170	2	2	2	1.1	O=C(O)c1n[nH]c(C2CC2)c1F	10.1016/j.bmcl.2007.07.101
	117629482	2823	140	None	-4	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.03.062
	1588	2823	140	None	-4	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.03.062
	1594	2823	140	None	-4	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.03.062
	2835	2823	140	None	-4	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.03.062
	938	2823	140	None	-4	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.03.062
	CHEMBL573	2823	140	None	-4	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.03.062
	DB00627	2823	140	None	-4	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.03.062
	135800194	89491	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	354	6	3	7	2.1	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1ccccc1C(=O)O	10.1021/jm100022r
	CHEMBL237248	89491	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	354	6	3	7	2.1	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1ccccc1C(=O)O	10.1021/jm100022r
	135800194	89491	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	354	6	3	7	2.1	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	CHEMBL237248	89491	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	354	6	3	7	2.1	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	135966934	6842	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	452	7	3	7	3.3	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CC(c2cccc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1084030	6842	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	452	7	3	7	3.3	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CC(c2cccc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
	135800194	89491	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	354	6	3	7	2.1	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	CHEMBL237248	89491	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	354	6	3	7	2.1	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	11607970	2552	10	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	164	1	2	2	0.8	OC(=O)c1n[nH]c2c1CC1C2C1	10.1021/jm2010964
	5785	2552	10	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	164	1	2	2	0.8	OC(=O)c1n[nH]c2c1CC1C2C1	10.1021/jm2010964
	CHEMBL2059221	2552	10	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	164	1	2	2	0.8	OC(=O)c1n[nH]c2c1CC1C2C1	10.1021/jm2010964
	11646179	184813	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	359	5	3	3	4.0	O=C(CCc1ccc2c(ccc3[nH]ncc32)c1)Nc1ccccc1C(=O)O	10.1021/jm900151e
	CHEMBL485185	184813	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	359	5	3	3	4.0	O=C(CCc1ccc2c(ccc3[nH]ncc32)c1)Nc1ccccc1C(=O)O	10.1021/jm900151e
	57400595	69931	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	366	4	1	5	3.0	CCc1cc(=O)oc2nc(OCc3ccc(C(F)(F)F)cc3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939026	69931	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	366	4	1	5	3.0	CCc1cc(=O)oc2nc(OCc3ccc(C(F)(F)F)cc3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	117629482	2823	140	None	3	4	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assayAgonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
	1588	2823	140	None	3	4	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assayAgonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
	1594	2823	140	None	3	4	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assayAgonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
	2835	2823	140	None	3	4	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assayAgonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
	938	2823	140	None	3	4	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assayAgonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
	CHEMBL573	2823	140	None	3	4	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assayAgonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
	DB00627	2823	140	None	3	4	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assayAgonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
	137653026	158707	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	329	3	2	2	3.3	O=C(/C=C/C#Cc1ccccc1Cl)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4093294	158707	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	329	3	2	2	3.3	O=C(/C=C/C#Cc1ccccc1Cl)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	44351665	116846	26	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	154	1	2	3	0.1	O=C(O)c1[nH]nc2c1COC2	10.1016/j.bmcl.2007.06.028
	CHEMBL338071	116846	26	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	154	1	2	3	0.1	O=C(O)c1[nH]nc2c1COC2	10.1016/j.bmcl.2007.06.028
	11494579	1058	0	None	-123	2	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assayAgonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assay	ChEMBL	377	5	3	5	2.9	O=C(Nc1ccccc1C(=O)O)CCc1cnn2c1CCc1c2ccc(c1)O	10.1021/jm900151e
	5791	1058	0	None	-123	2	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assayAgonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assay	ChEMBL	377	5	3	5	2.9	O=C(Nc1ccccc1C(=O)O)CCc1cnn2c1CCc1c2ccc(c1)O	10.1021/jm900151e
	CHEMBL482768	1058	0	None	-123	2	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assayAgonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assay	ChEMBL	377	5	3	5	2.9	O=C(Nc1ccccc1C(=O)O)CCc1cnn2c1CCc1c2ccc(c1)O	10.1021/jm900151e
	53324022	58051	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	258	2	1	4	1.6	CCc1cc(=O)oc2nc(C(F)Cl)[nH]c(=O)c12	10.1021/ml100251u
	CHEMBL1672745	58051	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	258	2	1	4	1.6	CCc1cc(=O)oc2nc(C(F)Cl)[nH]c(=O)c12	10.1021/ml100251u
	117629482	2823	140	None	-4	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	1588	2823	140	None	-4	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	1594	2823	140	None	-4	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	2835	2823	140	None	-4	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	938	2823	140	None	-4	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	CHEMBL573	2823	140	None	-4	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	DB00627	2823	140	None	-4	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	90645407	112519	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	356	4	2	3	3.9	O=C(/C=C/c1cc2ccccc2nc1Cl)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	CHEMBL3299016	112519	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	356	4	2	3	3.9	O=C(/C=C/c1cc2ccccc2nc1Cl)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	53324024	58058	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	284	4	1	4	2.4	CC(C)CCc1cc(=O)oc2nc(C(F)F)[nH]c(=O)c12	10.1021/ml100251u
	CHEMBL1672753	58058	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	284	4	1	4	2.4	CC(C)CCc1cc(=O)oc2nc(C(F)F)[nH]c(=O)c12	10.1021/ml100251u
	145960556	162222	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	454	3	1	6	4.9	CCc1cc(C2Nc3ccccc3C(=O)N2C)cc2cc(-c3ccc4c(c3)OCO4)c(=O)oc12	10.1016/j.ejmech.2018.04.037
	CHEMBL4163051	162222	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	454	3	1	6	4.9	CCc1cc(C2Nc3ccccc3C(=O)N2C)cc2cc(-c3ccc4c(c3)OCO4)c(=O)oc12	10.1016/j.ejmech.2018.04.037
	117629482	2823	140	None	-4	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	1588	2823	140	None	-4	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	1594	2823	140	None	-4	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	2835	2823	140	None	-4	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	938	2823	140	None	-4	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	CHEMBL573	2823	140	None	-4	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	DB00627	2823	140	None	-4	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.ejmech.2018.04.037
	46889342	7183	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	228	2	2	4	1.1	C/C=C/[C@@H]1[C@H]2Cc3c(-c4nnn[nH]4)n[nH]c3[C@@H]12	10.1016/j.bmcl.2010.03.062
	CHEMBL1085537	7183	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	228	2	2	4	1.1	C/C=C/[C@@H]1[C@H]2Cc3c(-c4nnn[nH]4)n[nH]c3[C@@H]12	10.1016/j.bmcl.2010.03.062
	57412400	76119	1	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	192	2	2	2	1.4	CC[C@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@H]12	10.1021/jm2010964
	CHEMBL2057620	76119	1	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	192	2	2	2	1.4	CC[C@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@H]12	10.1021/jm2010964
	145960556	162222	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	454	3	1	6	4.9	CCc1cc(C2Nc3ccccc3C(=O)N2C)cc2cc(-c3ccc4c(c3)OCO4)c(=O)oc12	10.1016/j.ejmech.2018.04.037
	CHEMBL4163051	162222	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	454	3	1	6	4.9	CCc1cc(C2Nc3ccccc3C(=O)N2C)cc2cc(-c3ccc4c(c3)OCO4)c(=O)oc12	10.1016/j.ejmech.2018.04.037
	57413541	76474	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	204	3	2	2	1.6	C=CC[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	CHEMBL2059827	76474	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	204	3	2	2	1.6	C=CC[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	46890298	7162	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	433	6	3	3	5.0	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2cccc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1085414	7162	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	433	6	3	3	5.0	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2cccc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
	15605646	75245	1	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	264	5	2	4	1.3	CCCCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036826	75245	1	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	264	5	2	4	1.3	CCCCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	24953854	69952	0	None	-1	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat nicotinic acid receptorAgonist activity at rat nicotinic acid receptor	ChEMBL	328	5	1	5	2.4	CCC#CCOc1nc2oc(=O)cc(CCC3CCC3)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939047	69952	0	None	-1	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat nicotinic acid receptorAgonist activity at rat nicotinic acid receptor	ChEMBL	328	5	1	5	2.4	CCC#CCOc1nc2oc(=O)cc(CCC3CCC3)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	11218626	84892	0	None	-1	2	Human	5.6	pEC50	=	5.6	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1csc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	CHEMBL223623	84892	0	None	-1	2	Human	5.6	pEC50	=	5.6	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1csc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	156011372	177352	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	415	10	3	9	1.9	COCCCn1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
	CHEMBL4637548	177352	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	415	10	3	9	1.9	COCCCn1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
	11557600	167382	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	220	3	2	2	1.8	O=C(O)c1cc(Cc2cccc(F)c2)[nH]n1	10.1016/j.bmcl.2007.06.028
	CHEMBL429495	167382	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	220	3	2	2	1.8	O=C(O)c1cc(Cc2cccc(F)c2)[nH]n1	10.1016/j.bmcl.2007.06.028
	12003699	196054	5	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	242	2	2	2	2.4	O=C(O)c1n[nH]c2c1CC(c1ccccc1)CC2	10.1016/j.bmcl.2009.06.054
	CHEMBL560405	196054	5	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	242	2	2	2	2.4	O=C(O)c1n[nH]c2c1CC(c1ccccc1)CC2	10.1016/j.bmcl.2009.06.054
	53326591	58040	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	314	5	1	4	2.6	O=c1cc(CCCC2(F)CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1672645	58040	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	314	5	1	4	2.6	O=c1cc(CCCC2(F)CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	15605364	69918	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	262	4	1	5	1.2	CCc1cc(=O)oc2nc(OCC3CC3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939013	69918	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	262	4	1	5	1.2	CCc1cc(=O)oc2nc(OCC3CC3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	11159621	2548	46	None	-1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2010.03.062
	5784	2548	46	None	-1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2010.03.062
	CHEMBL456145	2548	46	None	-1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2010.03.062
	DB05939	2548	46	None	-1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2010.03.062
	11159621	2548	46	None	-1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm2010964
	5784	2548	46	None	-1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm2010964
	CHEMBL456145	2548	46	None	-1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm2010964
	DB05939	2548	46	None	-1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm2010964
	46889398	6832	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	216	1	2	4	0.9	CC1(C)[C@H]2Cc3c(-c4nnn[nH]4)n[nH]c3[C@H]21	10.1016/j.bmcl.2010.03.062
	CHEMBL1083989	6832	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	216	1	2	4	0.9	CC1(C)[C@H]2Cc3c(-c4nnn[nH]4)n[nH]c3[C@H]21	10.1016/j.bmcl.2010.03.062
	117629482	2823	140	None	3	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	117629482	2823	140	None	3	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	1588	2823	140	None	3	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	1588	2823	140	None	3	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	1594	2823	140	None	3	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	1594	2823	140	None	3	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	2835	2823	140	None	3	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	2835	2823	140	None	3	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	938	2823	140	None	3	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	938	2823	140	None	3	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	CHEMBL573	2823	140	None	3	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	CHEMBL573	2823	140	None	3	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	DB00627	2823	140	None	3	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	DB00627	2823	140	None	3	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	11380943	83459	1	None	20	2	Human	6.5	pEC50	=	6.5	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL219980	83459	1	None	20	2	Human	6.5	pEC50	=	6.5	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	135416391	6920	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	372	6	3	7	2.4	CC(CC(=O)NC1=C(C(=O)O)CCCC1)c1nc(-c2ccc(O)cn2)no1	10.1021/jm100022r
	CHEMBL1084393	6920	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	372	6	3	7	2.4	CC(CC(=O)NC1=C(C(=O)O)CCCC1)c1nc(-c2ccc(O)cn2)no1	10.1021/jm100022r
	135416393	7629	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	374	6	4	8	0.8	O=C(O)C1=C(NC(=O)C(O)Cc2nc(-c3ccc(O)cn3)no2)CCCC1	10.1021/jm100022r
	CHEMBL1088213	7629	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	374	6	4	8	0.8	O=C(O)C1=C(NC(=O)C(O)Cc2nc(-c3ccc(O)cn3)no2)CCCC1	10.1021/jm100022r
	57400594	69930	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	366	4	1	5	3.0	CCc1cc(=O)oc2nc(OCc3cccc(C(F)(F)F)c3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939025	69930	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	366	4	1	5	3.0	CCc1cc(=O)oc2nc(OCc3cccc(C(F)(F)F)c3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	136000579	61400	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	368	6	4	7	1.6	N[C@@H](Cc1nc(-c2ccc(O)cc2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	CHEMBL1770175	61400	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	368	6	4	7	1.6	N[C@@H](Cc1nc(-c2ccc(O)cc2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	59304795	75233	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	194	0	2	4	-0.5	Cc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036811	75233	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	194	0	2	4	-0.5	Cc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	156017210	177730	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	414	8	4	3	5.1	CCCCc1cc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)[nH]1	10.1016/j.bmcl.2020.127105
	CHEMBL4642367	177730	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	414	8	4	3	5.1	CCCCc1cc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)[nH]1	10.1016/j.bmcl.2020.127105
	78346	93750	133	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	124	1	1	3	0.2	O=C(O)c1cncnc1	10.1016/j.bmcl.2007.06.028
	CHEMBL247316	93750	133	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	124	1	1	3	0.2	O=C(O)c1cncnc1	10.1016/j.bmcl.2007.06.028
	57402398	69934	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	394	5	1	7	2.6	CCc1cc(=O)oc2nc(OCc3ccc(-c4cncnc4)cc3F)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939029	69934	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	394	5	1	7	2.6	CCc1cc(=O)oc2nc(OCc3ccc(-c4cncnc4)cc3F)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	3159638	161911	61	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	154	2	2	2	1.0	CCc1[nH]nc(C(=O)O)c1C	10.1016/j.bmcl.2007.07.101
	CHEMBL415261	161911	61	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	154	2	2	2	1.0	CCc1[nH]nc(C(=O)O)c1C	10.1016/j.bmcl.2007.07.101
	136000718	61402	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	368	6	4	7	2.2	N[C@H](CC(=O)Nc1ccccc1C(=O)O)c1nc(-c2ccc(O)cc2)no1	10.1016/j.bmcl.2010.11.116
	CHEMBL1770177	61402	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	368	6	4	7	2.2	N[C@H](CC(=O)Nc1ccccc1C(=O)O)c1nc(-c2ccc(O)cc2)no1	10.1016/j.bmcl.2010.11.116
	137655320	158538	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	313	4	3	3	2.6	O=C(CCC#Cc1cccc(O)c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4091501	158538	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	313	4	3	3	2.6	O=C(CCC#Cc1cccc(O)c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	59343664	75256	0	None	-1	4	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	272	4	2	4	0.8	O=c1[nH]c(=O)c2c(CCCC(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036951	75256	0	None	-1	4	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	272	4	2	4	0.8	O=c1[nH]c(=O)c2c(CCCC(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	51346919	57843	6	None	1	4	Rat	8.5	pEC50	=	8.5	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	296	5	1	4	2.5	O=c1cc(CCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1671877	57843	6	None	1	4	Rat	8.5	pEC50	=	8.5	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	296	5	1	4	2.5	O=c1cc(CCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	46890270	7375	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	395	8	3	3	4.9	CCCCC1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
	CHEMBL1086354	7375	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	395	8	3	3	4.9	CCCCC1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
	145949989	162960	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	410	2	1	4	5.3	Cc1ccc(-c2cc3cc(C4Nc5ccccc5C(=O)N4C)cc(C)c3oc2=O)cc1	10.1016/j.ejmech.2018.04.037
	CHEMBL4174798	162960	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	410	2	1	4	5.3	Cc1ccc(-c2cc3cc(C4Nc5ccccc5C(=O)N4C)cc(C)c3oc2=O)cc1	10.1016/j.ejmech.2018.04.037
	145949989	162960	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	410	2	1	4	5.3	Cc1ccc(-c2cc3cc(C4Nc5ccccc5C(=O)N4C)cc(C)c3oc2=O)cc1	10.1016/j.ejmech.2018.04.037
	CHEMBL4174798	162960	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assayAgonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated with cells followed by forskolin addition measured after 10 mins by luminescence assay	ChEMBL	410	2	1	4	5.3	Cc1ccc(-c2cc3cc(C4Nc5ccccc5C(=O)N4C)cc(C)c3oc2=O)cc1	10.1016/j.ejmech.2018.04.037
	44579763	186983	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	428	7	1	5	5.0	Cc1c(C(=O)N[C@@H](C)COc2ccccc2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
	CHEMBL490600	186983	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	428	7	1	5	5.0	Cc1c(C(=O)N[C@@H](C)COc2ccccc2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
	24955642	58057	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	298	6	1	4	2.9	CCCCCCc1cc(=O)oc2nc(C(F)F)[nH]c(=O)c12	10.1021/ml100251u
	CHEMBL1672752	58057	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	298	6	1	4	2.9	CCCCCCc1cc(=O)oc2nc(C(F)F)[nH]c(=O)c12	10.1021/ml100251u
	46890297	7214	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	433	6	3	3	5.0	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccccc2F)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1085653	7214	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	433	6	3	3	5.0	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccccc2F)CC1	10.1016/j.bmcl.2010.04.001
	15605287	75232	2	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	208	1	2	4	-0.3	CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036810	75232	2	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	208	1	2	4	-0.3	CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	70686047	75253	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	250	3	2	4	0.8	CCC(C)Cc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036947	75253	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	250	3	2	4	0.8	CCC(C)Cc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	53324033	58033	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	298	4	1	5	2.0	CCc1cc(=O)oc2nc(COc3ccccc3)[nH]c(=O)c12	10.1021/ml100251u
	CHEMBL1672638	58033	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	298	4	1	5	2.0	CCc1cc(=O)oc2nc(COc3ccccc3)[nH]c(=O)c12	10.1021/ml100251u
	57412214	76114	1	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	178	1	2	2	1.0	C[C@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@H]12	10.1021/jm2010964
	CHEMBL2057615	76114	1	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	178	1	2	2	1.0	C[C@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@H]12	10.1021/jm2010964
	53317467	58039	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	372	6	1	4	3.9	O=c1cc(CCCC2(c3ccccc3)CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1672643	58039	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	372	6	1	4	3.9	O=c1cc(CCCC2(c3ccccc3)CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	57390149	69946	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	276	3	2	6	-0.2	CCc1cc(=O)oc2nc(OCC#CCO)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939041	69946	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	276	3	2	6	-0.2	CCc1cc(=O)oc2nc(OCC#CCO)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	57390147	69924	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	290	4	1	5	2.0	COc1nc2oc(=O)cc(CCC3CCCC3)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939019	69924	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	290	4	1	5	2.0	COc1nc2oc(=O)cc(CCC3CCCC3)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	136375437	178081	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	432	8	3	7	3.6	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1cn(Cc2ccccc2)cc1C(=O)O	10.1016/j.bmcl.2020.127105
	CHEMBL4647670	178081	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	432	8	3	7	3.6	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1cn(Cc2ccccc2)cc1C(=O)O	10.1016/j.bmcl.2020.127105
	44580007	186947	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	366	6	1	5	3.6	COCC(C)NC(=O)c1cnc2c(-c3ccc(C(C)C)cc3)cnn2c1C	10.1016/j.bmcl.2008.08.039
	CHEMBL490215	186947	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	366	6	1	5	3.6	COCC(C)NC(=O)c1cnc2c(-c3ccc(C(C)C)cc3)cnn2c1C	10.1016/j.bmcl.2008.08.039
	54587625	61396	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	376	6	4	4	3.3	N[C@@H](Cc1ccc(-c2ccc(O)cc2)cc1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	CHEMBL1770171	61396	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	376	6	4	4	3.3	N[C@@H](Cc1ccc(-c2ccc(O)cc2)cc1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	53318746	58036	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	324	6	1	4	3.3	CCC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	CHEMBL1672640	58036	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	324	6	1	4	3.3	CCC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	16048919	94683	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	407	4	2	6	2.7	COc1cccc2nc(N3CCN(C(=O)Nc4ccccc4C(=O)O)CC3)cnc12	10.1016/j.bmcl.2007.10.055
	CHEMBL252708	94683	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	407	4	2	6	2.7	COc1cccc2nc(N3CCN(C(=O)Nc4ccccc4C(=O)O)CC3)cnc12	10.1016/j.bmcl.2007.10.055
	11470032	84748	1	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	219	2	1	4	0.9	CC1(c2cccnc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL222949	84748	1	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	219	2	1	4	0.9	CC1(c2cccnc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	53326616	58050	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	224	2	1	4	0.9	CCc1cc(=O)oc2nc(CF)[nH]c(=O)c12	10.1021/ml100251u
	CHEMBL1672744	58050	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	224	2	1	4	0.9	CCc1cc(=O)oc2nc(CF)[nH]c(=O)c12	10.1021/ml100251u
	137659759	159267	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	314	4	3	4	1.9	O=C(CCC#Cc1ccc(O)cn1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4099278	159267	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	314	4	3	4	1.9	O=C(CCC#Cc1ccc(O)cn1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	53325309	58062	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	236	3	1	5	0.6	CCc1cc(=O)oc2nc(COC)[nH]c(=O)c12	10.1021/ml100251u
	CHEMBL1672768	58062	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	236	3	1	5	0.6	CCc1cc(=O)oc2nc(COC)[nH]c(=O)c12	10.1021/ml100251u
	11516324	184216	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	375	5	4	4	3.7	O=C(CCc1[nH]nc2c1ccc1cc(O)ccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
	CHEMBL483352	184216	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	375	5	4	4	3.7	O=C(CCc1[nH]nc2c1ccc1cc(O)ccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
	57398906	69944	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	286	3	1	5	1.2	CCc1cc(=O)oc2nc(OCC#CC3CC3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939039	69944	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	286	3	1	5	1.2	CCc1cc(=O)oc2nc(OCC#CC3CC3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	11493732	193100	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	335	5	3	3	3.8	O=C(CCc1ccc2cc(O)ccc2c1)Nc1ccccc1C(=O)O	10.1021/jm900151e
	CHEMBL522649	193100	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	335	5	3	3	3.8	O=C(CCc1ccc2cc(O)ccc2c1)Nc1ccccc1C(=O)O	10.1021/jm900151e
	135899178	16210	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109A receptor assessed as GTPgammaS bindingAgonist activity at human GPR109A receptor assessed as GTPgammaS binding	ChEMBL	315	5	1	4	2.7	O=c1[nH]c(COCCc2cccc(Cl)c2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	CHEMBL1224219	16210	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109A receptor assessed as GTPgammaS bindingAgonist activity at human GPR109A receptor assessed as GTPgammaS binding	ChEMBL	315	5	1	4	2.7	O=c1[nH]c(COCCc2cccc(Cl)c2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	11610260	145949	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	364	6	2	4	4.2	Cc1noc(C)c1-c1ccc(CCC(=O)Nc2ccccc2C(=O)O)cc1	10.1021/jm700942d
	CHEMBL391812	145949	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	364	6	2	4	4.2	Cc1noc(C)c1-c1ccc(CCC(=O)Nc2ccccc2C(=O)O)cc1	10.1021/jm700942d
	136088957	61403	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	368	6	4	7	2.2	N[C@@H](CC(=O)Nc1ccccc1C(=O)O)c1nc(-c2ccc(O)cc2)no1	10.1016/j.bmcl.2010.11.116
	CHEMBL1770178	61403	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	368	6	4	7	2.2	N[C@@H](CC(=O)Nc1ccccc1C(=O)O)c1nc(-c2ccc(O)cc2)no1	10.1016/j.bmcl.2010.11.116
	44433534	152411	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	210	4	2	4	1.1	CCCCc1[nH]nc(-c2nnn[nH]2)c1F	10.1016/j.bmcl.2007.07.101
	CHEMBL397056	152411	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	210	4	2	4	1.1	CCCCc1[nH]nc(-c2nnn[nH]2)c1F	10.1016/j.bmcl.2007.07.101
	28400046	89810	3	None	-32	2	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human GPR109a receptor transfected in CHOK1 cells assessed as reversal of forskolin induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109a receptor transfected in CHOK1 cells assessed as reversal of forskolin induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	1.8	CC(C)CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237737	89810	3	None	-32	2	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human GPR109a receptor transfected in CHOK1 cells assessed as reversal of forskolin induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109a receptor transfected in CHOK1 cells assessed as reversal of forskolin induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	1.8	CC(C)CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	53318768	58049	1	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	242	2	1	4	1.4	CCc1cc(=O)oc2nc(C(F)F)[nH]c(=O)c12	10.1021/ml100251u
	CHEMBL1672743	58049	1	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	242	2	1	4	1.4	CCc1cc(=O)oc2nc(C(F)F)[nH]c(=O)c12	10.1021/ml100251u
	136088958	61446	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	369	6	4	8	1.0	N[C@H](Cc1nc(-c2ccc(O)cn2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	CHEMBL1770353	61446	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	369	6	4	8	1.0	N[C@H](Cc1nc(-c2ccc(O)cn2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	137639493	156911	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	315	4	2	2	3.0	O=C(CCC#Cc1ccccc1F)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4072283	156911	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	315	4	2	2	3.0	O=C(CCC#Cc1ccccc1F)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	90645405	112533	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	295	3	2	2	2.6	O=C(/C=C/C#Cc1ccccc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	CHEMBL3299113	112533	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	295	3	2	2	2.6	O=C(/C=C/C#Cc1ccccc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	90645414	112421	0	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	338	5	2	3	3.5	Cc1ccc2cc(CCC(=O)NC3=C(C(=O)O)CCCC3)ccc2n1	10.1016/j.bmc.2014.05.011
	CHEMBL3297874	112421	0	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	338	5	2	3	3.5	Cc1ccc2cc(CCC(=O)NC3=C(C(=O)O)CCCC3)ccc2n1	10.1016/j.bmc.2014.05.011
	57413367	76113	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	178	1	2	2	1.0	C[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	CHEMBL2057614	76113	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	178	1	2	2	1.0	C[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	11436345	143	0	None	1	2	Human	6.4	pEC50	=	6.4	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1599	143	0	None	1	2	Human	6.4	pEC50	=	6.4	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL424938	143	0	None	1	2	Human	6.4	pEC50	=	6.4	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	11446592	149833	3	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	172	3	2	3	1.0	CSCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.06.028
	CHEMBL394885	149833	3	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	172	3	2	3	1.0	CSCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.06.028
	46889364	7238	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	244	4	2	4	1.7	CCCC[C@H]1[C@@H]2c3[nH]nc(-c4nnn[nH]4)c3C[C@@H]21	10.1016/j.bmcl.2010.03.062
	CHEMBL1085760	7238	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	244	4	2	4	1.7	CCCC[C@H]1[C@@H]2c3[nH]nc(-c4nnn[nH]4)c3C[C@@H]21	10.1016/j.bmcl.2010.03.062
	53317492	58045	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	310	4	1	4	2.8	CC1CC(CCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)C1	10.1021/ml100251u
	CHEMBL1672737	58045	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	310	4	1	4	2.8	CC1CC(CCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)C1	10.1021/ml100251u
	56659539	63818	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR109aAgonist activity at GPR109a	ChEMBL	337	5	3	4	3.3	O=C(COc1ccc2cc(O)ccc2c1)Nc1ccccc1C(=O)O	10.1021/jm200371q
	CHEMBL1802361	63818	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR109aAgonist activity at GPR109a	ChEMBL	337	5	3	4	3.3	O=C(COc1ccc2cc(O)ccc2c1)Nc1ccccc1C(=O)O	10.1021/jm200371q
	11493732	193100	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	335	5	3	3	3.8	O=C(CCc1ccc2cc(O)ccc2c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2008.08.030
	CHEMBL522649	193100	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	335	5	3	3	3.8	O=C(CCc1ccc2cc(O)ccc2c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2008.08.030
	12002802	195833	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	285	2	2	5	1.4	Fc1ncccc1C1CCc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.06.054
	CHEMBL558334	195833	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	285	2	2	5	1.4	Fc1ncccc1C1CCc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.06.054
	136088960	61448	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	373	6	4	8	0.7	N[C@@H](Cc1nc(-c2ccc(O)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.11.116
	CHEMBL1770355	61448	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	373	6	4	8	0.7	N[C@@H](Cc1nc(-c2ccc(O)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.11.116
	59304954	75261	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	276	4	2	4	1.3	O=c1[nH]c(=O)c2c(CCCC3CCC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036956	75261	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	276	4	2	4	1.3	O=c1[nH]c(=O)c2c(CCCC3CCC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	117629482	2823	140	None	-3	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	117629482	2823	140	None	-3	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	1588	2823	140	None	-3	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	1588	2823	140	None	-3	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	1594	2823	140	None	-3	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	1594	2823	140	None	-3	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	2835	2823	140	None	-3	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	2835	2823	140	None	-3	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	938	2823	140	None	-3	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	938	2823	140	None	-3	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	CHEMBL573	2823	140	None	-3	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	CHEMBL573	2823	140	None	-3	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	DB00627	2823	140	None	-3	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml100251u
	DB00627	2823	140	None	-3	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	137654580	159022	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	311	3	3	3	2.3	O=C(/C=C/C#Cc1cccc(O)c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4096635	159022	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	311	3	3	3	2.3	O=C(/C=C/C#Cc1cccc(O)c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	676464	89876	75	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	154	3	2	2	1.1	CCCc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.06.028
	CHEMBL237788	89876	75	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	154	3	2	2	1.1	CCCc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.06.028
	15604642	75254	0	None	1	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	250	3	2	4	0.8	CC(C)CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036948	75254	0	None	1	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	250	3	2	4	0.8	CC(C)CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	15604637	75260	0	None	-1	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	262	4	2	4	0.9	O=c1[nH]c(=O)c2c(CCCC3CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036955	75260	0	None	-1	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	262	4	2	4	0.9	O=c1[nH]c(=O)c2c(CCCC3CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	51346919	57843	6	None	-1	4	Mouse	8.4	pEC50	=	8.4	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	296	5	1	4	2.5	O=c1cc(CCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1671877	57843	6	None	-1	4	Mouse	8.4	pEC50	=	8.4	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	296	5	1	4	2.5	O=c1cc(CCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	59304608	75259	0	None	-3	4	Mouse	8.4	pEC50	=	8.4	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	262	3	2	4	0.9	O=c1[nH]c(=O)c2c(CCC3CCC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036954	75259	0	None	-3	4	Mouse	8.4	pEC50	=	8.4	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	262	3	2	4	0.9	O=c1[nH]c(=O)c2c(CCC3CCC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	15604642	75254	0	None	-1	3	Rat	8.4	pEC50	=	8.4	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	250	3	2	4	0.8	CC(C)CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036948	75254	0	None	-1	3	Rat	8.4	pEC50	=	8.4	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	250	3	2	4	0.8	CC(C)CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	11501698	192570	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	376	5	3	6	2.9	O=C(CCc1nnn2c1ccc1cc(O)ccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
	CHEMBL521326	192570	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	376	5	3	6	2.9	O=C(CCc1nnn2c1ccc1cc(O)ccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
	1597	1965	80	None	1	2	Human	6.4	pEC50	=	6.4	Functional	Activity at GPR109a assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109a assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	10.1021/jm800896z
	2736690	1965	80	None	1	2	Human	6.4	pEC50	=	6.4	Functional	Activity at GPR109a assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109a assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	10.1021/jm800896z
	CHEMBL381638	1965	80	None	1	2	Human	6.4	pEC50	=	6.4	Functional	Activity at GPR109a assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109a assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	10.1021/jm800896z
	11159621	2548	46	None	1	3	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity against mouse GPR109a assessed as GTPgammaS bindingAgonist activity against mouse GPR109a assessed as GTPgammaS binding	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	5784	2548	46	None	1	3	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity against mouse GPR109a assessed as GTPgammaS bindingAgonist activity against mouse GPR109a assessed as GTPgammaS binding	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	CHEMBL456145	2548	46	None	1	3	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity against mouse GPR109a assessed as GTPgammaS bindingAgonist activity against mouse GPR109a assessed as GTPgammaS binding	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	DB05939	2548	46	None	1	3	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity against mouse GPR109a assessed as GTPgammaS bindingAgonist activity against mouse GPR109a assessed as GTPgammaS binding	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
	11693991	88535	1	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	178	2	2	4	0.7	CC(C)c1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL235229	88535	1	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	178	2	2	4	0.7	CC(C)c1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	24180571	89929	26	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	144	1	2	2	0.6	Cc1[nH]nc(C(=O)O)c1F	10.1016/j.bmcl.2007.07.101
	CHEMBL238004	89929	26	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	144	1	2	2	0.6	Cc1[nH]nc(C(=O)O)c1F	10.1016/j.bmcl.2007.07.101
	24811199	6601	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	434	6	3	4	4.4	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2cccnc2F)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1083139	6601	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	434	6	3	4	4.4	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2cccnc2F)CC1	10.1016/j.bmcl.2010.04.001
	54584718	61451	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	374	6	2	6	2.5	C[C@@H]1CCC(C(=O)O)=C(NC(=O)CCc2nc(-c3ccc(F)cn3)no2)C1	10.1016/j.bmcl.2010.11.116
	CHEMBL1770359	61451	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	374	6	2	6	2.5	C[C@@H]1CCC(C(=O)O)=C(NC(=O)CCc2nc(-c3ccc(F)cn3)no2)C1	10.1016/j.bmcl.2010.11.116
	137650474	157279	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	365	6	3	3	4.0	O=C(CCc1ccc(-c2ccccc2O)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4076822	157279	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	365	6	3	3	4.0	O=C(CCc1ccc(-c2ccccc2O)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	90645406	112422	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	388	6	2	4	3.9	COc1ccc2nc(Cl)c(CCC(=O)NC3=C(C(=O)O)CCCC3)cc2c1	10.1016/j.bmc.2014.05.011
	CHEMBL3297875	112422	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	388	6	2	4	3.9	COc1ccc2nc(Cl)c(CCC(=O)NC3=C(C(=O)O)CCCC3)cc2c1	10.1016/j.bmc.2014.05.011
	90645404	112518	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	322	4	2	3	3.3	O=C(/C=C/c1ccc2ccccc2n1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	CHEMBL3299009	112518	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	322	4	2	3	3.3	O=C(/C=C/c1ccc2ccccc2n1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	11323649	84749	0	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	286	2	1	3	2.8	CC1(c2cc(Cl)ccc2Cl)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL222955	84749	0	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	286	2	1	3	2.8	CC1(c2cc(Cl)ccc2Cl)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	53321368	58059	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	324	4	1	4	3.3	O=c1cc(CCC2CCCCC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1672754	58059	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	324	4	1	4	3.3	O=c1cc(CCC2CCCCC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	57402397	69923	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	250	4	1	5	1.2	CCCCc1cc(=O)oc2nc(OC)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939018	69923	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	250	4	1	5	1.2	CCCCc1cc(=O)oc2nc(OC)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	136086829	7338	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	466	7	3	7	3.6	C[C@H]1CC(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)=C(C(=O)O)C[C@H]1c1cccc(F)c1	10.1016/j.bmcl.2010.04.001
	CHEMBL1086225	7338	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	466	7	3	7	3.6	C[C@H]1CC(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)=C(C(=O)O)C[C@H]1c1cccc(F)c1	10.1016/j.bmcl.2010.04.001
	11219885	83462	0	None	3	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	286	2	1	3	2.5	CC1(c2cccc(C(F)(F)F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL220001	83462	0	None	3	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	286	2	1	3	2.5	CC1(c2cccc(C(F)(F)F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	57397203	69955	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	274	4	1	5	1.2	CC#CCCOc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939050	69955	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	274	4	1	5	1.2	CC#CCCOc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	15605359	69941	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	260	3	1	5	0.8	CC#CCOc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939036	69941	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	260	3	1	5	0.8	CC#CCOc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	42625475	184209	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	414	5	3	5	4.3	O=C(CCc1noc2c1ccc1c(Cl)c(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
	CHEMBL483336	184209	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	414	5	3	5	4.3	O=C(CCc1noc2c1ccc1c(Cl)c(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
	57412216	76118	1	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	192	2	2	2	1.4	CC[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	CHEMBL2057619	76118	1	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	192	2	2	2	1.4	CC[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	11739420	84757	0	None	12	2	Human	6.4	pEC50	=	6.4	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	344	2	1	3	2.1	CC1(c2cccc(I)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL223013	84757	0	None	12	2	Human	6.4	pEC50	=	6.4	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	344	2	1	3	2.1	CC1(c2cccc(I)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	135800176	89400	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	369	6	3	6	3.2	O=C(CCc1cnc(-c2ccc(O)cn2)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	CHEMBL237037	89400	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	369	6	3	6	3.2	O=C(CCc1cnc(-c2ccc(O)cn2)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	46890268	6606	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	353	5	3	3	3.8	CC1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
	CHEMBL1083174	6606	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	353	5	3	3	3.8	CC1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
	44433526	88490	18	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	246	4	2	2	2.2	CCCCc1[nH]nc(C(=O)O)c1Br	10.1016/j.bmcl.2007.07.101
	CHEMBL235010	88490	18	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	246	4	2	2	2.2	CCCCc1[nH]nc(C(=O)O)c1Br	10.1016/j.bmcl.2007.07.101
	16048768	94450	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	405	3	2	5	3.5	C[C@H]1CN(C(=O)Nc2ccccc2C(=O)O)[C@H](C)CN1c1cnc2ccccc2n1	10.1016/j.bmcl.2007.10.055
	CHEMBL251222	94450	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	405	3	2	5	3.5	C[C@H]1CN(C(=O)Nc2ccccc2C(=O)O)[C@H](C)CN1c1cnc2ccccc2n1	10.1016/j.bmcl.2007.10.055
	12003785	196379	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	260	2	2	2	2.5	O=C(O)c1n[nH]c2c1CC(c1ccccc1F)CC2	10.1016/j.bmcl.2009.06.054
	CHEMBL562632	196379	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	260	2	2	2	2.5	O=C(O)c1n[nH]c2c1CC(c1ccccc1F)CC2	10.1016/j.bmcl.2009.06.054
	53318741	58054	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	256	3	1	4	1.8	CCCc1cc(=O)oc2nc(C(F)F)[nH]c(=O)c12	10.1021/ml100251u
	CHEMBL1672749	58054	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	256	3	1	4	1.8	CCCc1cc(=O)oc2nc(C(F)F)[nH]c(=O)c12	10.1021/ml100251u
	46889319	7130	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	188	1	2	4	0.2	C1c2c(-c3nnn[nH]3)n[nH]c2[C@H]2C[C@@H]12	10.1016/j.bmcl.2010.03.062
	CHEMBL1085289	7130	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	188	1	2	4	0.2	C1c2c(-c3nnn[nH]3)n[nH]c2[C@H]2C[C@@H]12	10.1016/j.bmcl.2010.03.062
	11560300	88539	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	395	6	3	3	5.0	O=C(CCc1ccc(-c2ccc(O)cc2Cl)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	CHEMBL235256	88539	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	395	6	3	3	5.0	O=C(CCc1ccc(-c2ccc(O)cc2Cl)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	46890577	6672	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	490	7	2	6	4.0	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2F)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1083442	6672	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	490	7	2	6	4.0	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2F)CC1	10.1016/j.bmcl.2010.04.001
	137640776	157004	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	313	3	2	2	2.8	O=C(/C=C/C#Cc1ccccc1F)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4073322	157004	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	313	3	2	2	2.8	O=C(/C=C/C#Cc1ccccc1F)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	90645403	112480	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	321	4	2	2	3.9	O=C(/C=C/c1ccc2ccccc2c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	CHEMBL3298700	112480	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	321	4	2	2	3.9	O=C(/C=C/c1ccc2ccccc2c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	12003791	194829	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
	CHEMBL1237147	194829	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
	CHEMBL539398	194829	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
	24955294	58042	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	282	4	1	4	2.2	O=c1cc(CCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1672733	58042	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	282	4	1	4	2.2	O=c1cc(CCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	145957123	162017	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	440	2	1	6	4.7	Cc1cc(C2Nc3ccccc3C(=O)N2C)cc2cc(-c3ccc4c(c3)OCO4)c(=O)oc12	10.1016/j.ejmech.2018.04.037
	CHEMBL4159670	162017	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	440	2	1	6	4.7	Cc1cc(C2Nc3ccccc3C(=O)N2C)cc2cc(-c3ccc4c(c3)OCO4)c(=O)oc12	10.1016/j.ejmech.2018.04.037
	145957123	162017	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	440	2	1	6	4.7	Cc1cc(C2Nc3ccccc3C(=O)N2C)cc2cc(-c3ccc4c(c3)OCO4)c(=O)oc12	10.1016/j.ejmech.2018.04.037
	CHEMBL4159670	162017	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assayAgonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assay	ChEMBL	440	2	1	6	4.7	Cc1cc(C2Nc3ccccc3C(=O)N2C)cc2cc(-c3ccc4c(c3)OCO4)c(=O)oc12	10.1016/j.ejmech.2018.04.037
	46890578	6391	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	505	7	3	7	3.0	NC(Cc1nc(-c2ccc(F)cn2)no1)C(=O)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2F)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1082294	6391	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	505	7	3	7	3.0	NC(Cc1nc(-c2ccc(F)cn2)no1)C(=O)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2F)CC1	10.1016/j.bmcl.2010.04.001
	44579647	193021	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	432	7	1	5	4.8	Cc1c(C(=O)NCCOc2ccc(F)cc2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
	CHEMBL522281	193021	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	432	7	1	5	4.8	Cc1c(C(=O)NCCOc2ccc(F)cc2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
	9822	145638	133	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	126	1	2	2	0.4	Cc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.06.028
	CHEMBL391574	145638	133	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	126	1	2	2	0.4	Cc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.06.028
	46890501	7246	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	375	6	3	7	1.2	NC(Cc1nc(-c2ccc(F)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1085816	7246	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	375	6	3	7	1.2	NC(Cc1nc(-c2ccc(F)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.001
	16048840	94044	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	391	3	2	5	3.1	O=C(O)c1ccccc1NC(=O)N1CCCN(c2cnc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
	CHEMBL248851	94044	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	391	3	2	5	3.1	O=C(O)c1ccccc1NC(=O)N1CCCN(c2cnc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
	135416394	2560	52	None	-288	3	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat GPR109A receptor by [35S]GTPgammaS binding assayAgonist activity at rat GPR109A receptor by [35S]GTPgammaS binding assay	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
	5788	2560	52	None	-288	3	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat GPR109A receptor by [35S]GTPgammaS binding assayAgonist activity at rat GPR109A receptor by [35S]GTPgammaS binding assay	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
	73755154	2560	52	None	-288	3	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat GPR109A receptor by [35S]GTPgammaS binding assayAgonist activity at rat GPR109A receptor by [35S]GTPgammaS binding assay	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
	CHEMBL1086657	2560	52	None	-288	3	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat GPR109A receptor by [35S]GTPgammaS binding assayAgonist activity at rat GPR109A receptor by [35S]GTPgammaS binding assay	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
	11367769	136564	1	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	208	2	1	4	1.1	CC1(c2ccco2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL373880	136564	1	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	208	2	1	4	1.1	CC1(c2ccco2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	11379903	84271	0	None	6	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL221282	84271	0	None	6	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	59304594	75243	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	290	3	2	5	1.0	O=c1[nH]c(=O)c2c(CCc3cccs3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036824	75243	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	290	3	2	5	1.0	O=c1[nH]c(=O)c2c(CCc3cccs3)cc(=O)oc2[nH]1	10.1021/ml200243g
	135401973	1022	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	393	3	3	6	2.4	Oc1ccc2c(c1)ncc(n2)N1CCN(CC1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2007.10.055
	5792	1022	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	393	3	3	6	2.4	Oc1ccc2c(c1)ncc(n2)N1CCN(CC1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2007.10.055
	CHEMBL398496	1022	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	393	3	3	6	2.4	Oc1ccc2c(c1)ncc(n2)N1CCN(CC1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2007.10.055
	53322689	58060	1	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	224	1	2	5	0.7	CCc1cc(=O)oc2nc(S)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1672755	58060	1	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	224	1	2	5	0.7	CCc1cc(=O)oc2nc(S)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	59304859	75248	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	300	4	2	6	-0.9	CS(=O)(=O)CCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036829	75248	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	300	4	2	6	-0.9	CS(=O)(=O)CCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	53322689	58060	1	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	224	1	2	5	0.7	CCc1cc(=O)oc2nc(S)[nH]c(=O)c12	10.1021/ml100251u
	CHEMBL1672755	58060	1	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	224	1	2	5	0.7	CCc1cc(=O)oc2nc(S)[nH]c(=O)c12	10.1021/ml100251u
	53321396	58044	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	310	5	1	4	2.9	O=c1cc(CCCC2CCC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1672736	58044	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	310	5	1	4	2.9	O=c1cc(CCCC2CCC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	11483496	126	0	None	14	2	Human	7.3	pEC50	=	7.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1589	126	0	None	14	2	Human	7.3	pEC50	=	7.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL375493	126	0	None	14	2	Human	7.3	pEC50	=	7.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	42625476	184210	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	379	5	3	5	3.2	O=C(CCc1cnn2c1ccc1cc(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
	CHEMBL483337	184210	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	379	5	3	5	3.2	O=C(CCc1cnn2c1ccc1cc(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
	11276453	84876	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1ccc(C2(C)OC(C(=O)O)=CC2=O)s1	10.1021/jm070022x
	CHEMBL223566	84876	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1ccc(C2(C)OC(C(=O)O)=CC2=O)s1	10.1021/jm070022x
	46890399	7285	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	419	6	3	5	3.6	Cn1nccc1C1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
	CHEMBL1086029	7285	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	419	6	3	5	3.6	Cn1nccc1C1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
	156013148	177468	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	356	6	3	7	2.1	Cn1cc(NC(=O)CCc2nc(-c3ccc(O)cc3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
	CHEMBL4639053	177468	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	356	6	3	7	2.1	Cn1cc(NC(=O)CCc2nc(-c3ccc(O)cc3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
	24955646	58034	0	None	-8	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	310	5	1	4	2.9	CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	CHEMBL1672639	58034	0	None	-8	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	310	5	1	4	2.9	CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	46890500	7245	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	360	6	2	6	2.2	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1085815	7245	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	360	6	2	6	2.2	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.001
	44441305	150121	1	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	188	3	2	3	-0.0	C[S+]([O-])Cc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.06.028
	CHEMBL395118	150121	1	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	188	3	2	3	-0.0	C[S+]([O-])Cc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.06.028
	15604641	75255	1	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	264	4	2	4	1.1	CC(C)CCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036950	75255	1	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	264	4	2	4	1.1	CC(C)CCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	59343664	75256	0	None	-2	4	Mouse	8.3	pEC50	=	8.3	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	272	4	2	4	0.8	O=c1[nH]c(=O)c2c(CCCC(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036951	75256	0	None	-2	4	Mouse	8.3	pEC50	=	8.3	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	272	4	2	4	0.8	O=c1[nH]c(=O)c2c(CCCC(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	59304608	75259	0	None	-5	4	Rat	8.3	pEC50	=	8.3	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	262	3	2	4	0.9	O=c1[nH]c(=O)c2c(CCC3CCC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036954	75259	0	None	-5	4	Rat	8.3	pEC50	=	8.3	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	262	3	2	4	0.9	O=c1[nH]c(=O)c2c(CCC3CCC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	135466520	184217	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	378	5	3	5	3.4	O=C(CCc1noc2c1CCc1cc(O)ccc1-2)Nc1ccccc1C(=O)O	10.1021/jm900151e
	CHEMBL483353	184217	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	378	5	3	5	3.4	O=C(CCc1noc2c1CCc1cc(O)ccc1-2)Nc1ccccc1C(=O)O	10.1021/jm900151e
	135899171	16170	0	None	18	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109A receptor assessed as GTPgammaS bindingAgonist activity at human GPR109A receptor assessed as GTPgammaS binding	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	CHEMBL1224070	16170	0	None	18	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109A receptor assessed as GTPgammaS bindingAgonist activity at human GPR109A receptor assessed as GTPgammaS binding	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	776416	18938	108	None	5	2	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulationAgonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulation	ChEMBL	152	1	2	2	0.6	O=C(O)c1n[nH]c2c1CCC2	10.1021/jm800258p
	CHEMBL128604	18938	108	None	5	2	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulationAgonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulation	ChEMBL	152	1	2	2	0.6	O=C(O)c1n[nH]c2c1CCC2	10.1021/jm800258p
	11594881	88638	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	319	5	2	2	4.1	O=C(CCc1ccc2ccccc2c1)Nc1ccccc1C(=O)O	10.1021/jm900151e
	CHEMBL235740	88638	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	319	5	2	2	4.1	O=C(CCc1ccc2ccccc2c1)Nc1ccccc1C(=O)O	10.1021/jm900151e
	98845	93716	125	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	143	1	1	3	1.2	Cc1ncc(C(=O)O)s1	10.1016/j.bmcl.2007.06.028
	CHEMBL247134	93716	125	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	143	1	1	3	1.2	Cc1ncc(C(=O)O)s1	10.1016/j.bmcl.2007.06.028
	136088959	61447	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	383	6	4	8	1.6	CC(c1nc(-c2ccc(O)cn2)no1)[C@H](N)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	CHEMBL1770354	61447	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	383	6	4	8	1.6	CC(c1nc(-c2ccc(O)cn2)no1)[C@H](N)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	11183677	83463	1	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	224	2	1	4	1.5	CC1(c2cccs2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL220004	83463	1	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	224	2	1	4	1.5	CC1(c2cccs2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	117629482	2823	140	None	-4	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
	1588	2823	140	None	-4	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
	1594	2823	140	None	-4	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
	2835	2823	140	None	-4	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
	938	2823	140	None	-4	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
	CHEMBL573	2823	140	None	-4	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
	DB00627	2823	140	None	-4	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
	16048839	155016	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	382	3	2	5	3.3	O=C(O)c1ccccc1NC(=O)N1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmcl.2007.10.055
	CHEMBL401469	155016	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	382	3	2	5	3.3	O=C(O)c1ccccc1NC(=O)N1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmcl.2007.10.055
	46889337	6723	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	216	2	2	4	0.9	CC[C@H]1[C@@H]2c3[nH]nc(-c4nnn[nH]4)c3C[C@@H]21	10.1016/j.bmcl.2010.03.062
	CHEMBL1083682	6723	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	216	2	2	4	0.9	CC[C@H]1[C@@H]2c3[nH]nc(-c4nnn[nH]4)c3C[C@@H]21	10.1016/j.bmcl.2010.03.062
	46889340	7181	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	228	2	2	4	0.9	C1CC1[C@@H]1[C@H]2Cc3c(-c4nnn[nH]4)n[nH]c3[C@H]21	10.1016/j.bmcl.2010.03.062
	CHEMBL1085535	7181	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	228	2	2	4	0.9	C1CC1[C@@H]1[C@H]2Cc3c(-c4nnn[nH]4)n[nH]c3[C@H]21	10.1016/j.bmcl.2010.03.062
	42625379	192091	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	376	5	3	5	4.0	O=C(CCc1noc2c1ccc1cc(O)ccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
	CHEMBL520299	192091	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	376	5	3	5	4.0	O=C(CCc1noc2c1ccc1cc(O)ccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
	117629482	2823	140	None	-4	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm2010964
	1588	2823	140	None	-4	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm2010964
	1594	2823	140	None	-4	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm2010964
	2835	2823	140	None	-4	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm2010964
	938	2823	140	None	-4	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm2010964
	CHEMBL573	2823	140	None	-4	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm2010964
	DB00627	2823	140	None	-4	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm2010964
	90645411	112423	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	317	5	2	4	2.4	O=C(CCc1ccc2c(c1)OCO2)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	CHEMBL3297876	112423	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	317	5	2	4	2.4	O=C(CCc1ccc2c(c1)OCO2)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	1595	259	49	None	4	2	Human	6.3	pEC50	=	6.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	51576	259	49	None	4	2	Human	6.3	pEC50	=	6.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	CHEMBL278488	259	49	None	4	2	Human	6.3	pEC50	=	6.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	117629482	2823	140	None	-4	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
	1588	2823	140	None	-4	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
	1594	2823	140	None	-4	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
	2835	2823	140	None	-4	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
	938	2823	140	None	-4	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
	CHEMBL573	2823	140	None	-4	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
	DB00627	2823	140	None	-4	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
	24954935	69943	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	288	4	1	5	1.6	CCCC#CCOc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939038	69943	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	288	4	1	5	1.6	CCCC#CCOc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	1596	260	96	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	10.1021/jm070022x
	5310993	260	96	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	10.1021/jm070022x
	76	260	96	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	10.1021/jm070022x
	CHEMBL345714	260	96	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	10.1021/jm070022x
	DB09055	260	96	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	10.1021/jm070022x
	120232	153285	132	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	141	1	1	2	0.9	O=C(O)c1cncc(F)c1	10.1016/j.bmcl.2007.06.028
	CHEMBL397783	153285	132	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	141	1	1	2	0.9	O=C(O)c1cncc(F)c1	10.1016/j.bmcl.2007.06.028
	46890296	7213	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	364	5	3	4	3.3	N#CC1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
	CHEMBL1085652	7213	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	364	5	3	4	3.3	N#CC1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
	57412297	76472	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	220	3	2	2	2.0	CC(C)C[C@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	CHEMBL2059822	76472	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	220	3	2	2	2.0	CC(C)C[C@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	11638560	187043	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	334	5	3	3	3.7	Nc1ccc2cc(CCC(=O)Nc3ccccc3C(=O)O)ccc2c1	10.1016/j.bmcl.2008.08.030
	CHEMBL491002	187043	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	334	5	3	3	3.7	Nc1ccc2cc(CCC(=O)Nc3ccccc3C(=O)O)ccc2c1	10.1016/j.bmcl.2008.08.030
	11345283	85011	1	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	232	2	1	3	1.8	Cc1cccc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	CHEMBL223878	85011	1	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	232	2	1	3	1.8	Cc1cccc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	11264843	137620	1	None	1	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	236	2	1	3	1.6	CC1(c2ccc(F)cc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL375762	137620	1	None	1	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	236	2	1	3	1.6	CC1(c2ccc(F)cc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	46889341	7182	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	230	3	2	4	1.3	CCC[C@H]1[C@@H]2c3[nH]nc(-c4nnn[nH]4)c3C[C@@H]21	10.1016/j.bmcl.2010.03.062
	CHEMBL1085536	7182	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayAgonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay	ChEMBL	230	3	2	4	1.3	CCC[C@H]1[C@@H]2c3[nH]nc(-c4nnn[nH]4)c3C[C@@H]21	10.1016/j.bmcl.2010.03.062
	57412218	76350	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	220	4	2	2	2.2	CCCC[C@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@H]12	10.1021/jm2010964
	CHEMBL2059225	76350	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	220	4	2	2	2.2	CCCC[C@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@H]12	10.1021/jm2010964
	52941721	54965	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	283	1	0	7	4.2	Fc1ncccc1C1CCC2=C(C1)C(=C1N=NN=N1)N=N2	10.1016/j.bmcl.2009.06.054
	CHEMBL1204125	54965	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	283	1	0	7	4.2	Fc1ncccc1C1CCC2=C(C1)C(=C1N=NN=N1)N=N2	10.1016/j.bmcl.2009.06.054
	CHEMBL1615577	54965	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	283	1	0	7	4.2	Fc1ncccc1C1CCC2=C(C1)C(=C1N=NN=N1)N=N2	10.1016/j.bmcl.2009.06.054
	44441323	93833	10	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	170	1	2	3	0.9	O=C(O)c1[nH]nc2c1CSC2	10.1016/j.bmcl.2007.06.028
	CHEMBL247724	93833	10	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	170	1	2	3	0.9	O=C(O)c1[nH]nc2c1CSC2	10.1016/j.bmcl.2007.06.028
	44441312	93864	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	196	6	2	2	2.2	CCCCCCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.06.028
	CHEMBL247922	93864	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	196	6	2	2	2.2	CCCCCCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.06.028
	137648318	157632	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	341	5	3	3	2.5	O=C(CCC#Cc1ccc(C(=O)O)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4081260	157632	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	341	5	3	3	2.5	O=C(CCC#Cc1ccc(C(=O)O)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	44433524	152208	29	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	158	2	2	2	0.8	CCc1[nH]nc(C(=O)O)c1F	10.1016/j.bmcl.2007.07.101
	CHEMBL396864	152208	29	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	158	2	2	2	0.8	CCc1[nH]nc(C(=O)O)c1F	10.1016/j.bmcl.2007.07.101
	11380943	83459	1	None	20	2	Human	6.2	pEC50	=	6.2	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL219980	83459	1	None	20	2	Human	6.2	pEC50	=	6.2	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	11368347	84946	1	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	236	2	1	3	1.6	CC1(c2ccccc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL223754	84946	1	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	236	2	1	3	1.6	CC1(c2ccccc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	57412214	76114	1	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	178	1	2	2	1.0	C[C@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@H]12	10.1021/jm2010964
	CHEMBL2057615	76114	1	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	178	1	2	2	1.0	C[C@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@H]12	10.1021/jm2010964
	135401975	94748	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	393	3	3	6	2.4	O=C(O)c1ccccc1NC(=O)N1CCN(c2cnc3ccc(O)cc3n2)CC1	10.1016/j.bmcl.2007.10.055
	CHEMBL253128	94748	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	393	3	3	6	2.4	O=C(O)c1ccccc1NC(=O)N1CCN(c2cnc3ccc(O)cc3n2)CC1	10.1016/j.bmcl.2007.10.055
	90645410	112534	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	315	4	2	4	2.5	O=C(/C=C/c1ccc2c(c1)OCO2)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	CHEMBL3299114	112534	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	315	4	2	4	2.5	O=C(/C=C/c1ccc2c(c1)OCO2)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	57391931	69938	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	345	6	1	7	2.1	CCc1noc(CC)c1COc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939033	69938	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	345	6	1	7	2.1	CCc1noc(CC)c1COc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	44433533	89190	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	194	2	2	4	0.6	Fc1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	CHEMBL236728	89190	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	194	2	2	4	0.6	Fc1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	51346919	57843	6	None	-19	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	296	5	1	4	2.5	O=c1cc(CCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1671877	57843	6	None	-19	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	296	5	1	4	2.5	O=c1cc(CCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	11617151	88639	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	345	6	2	2	4.6	O=C(CCc1ccc(-c2ccccc2)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	CHEMBL235741	88639	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	345	6	2	2	4.6	O=C(CCc1ccc(-c2ccccc2)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	11617151	88639	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	345	6	2	2	4.6	O=C(CCc1ccc(-c2ccccc2)cc1)Nc1ccccc1C(=O)O	10.1021/jm900151e
	CHEMBL235741	88639	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	345	6	2	2	4.6	O=C(CCc1ccc(-c2ccccc2)cc1)Nc1ccccc1C(=O)O	10.1021/jm900151e
	16048998	94632	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	376	3	2	4	3.3	O=C(O)c1ccccc1NC(=O)N1CCN(c2ccc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
	CHEMBL252307	94632	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	376	3	2	4	3.3	O=C(O)c1ccccc1NC(=O)N1CCN(c2ccc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
	53324057	58047	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	310	6	1	4	2.9	O=c1cc(CCCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1672741	58047	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	310	6	1	4	2.9	O=c1cc(CCCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	135453098	88734	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	402	6	3	5	4.4	O=C(CCc1cnc(-c2ccc(O)cc2Cl)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	CHEMBL236162	88734	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	402	6	3	5	4.4	O=C(CCc1cnc(-c2ccc(O)cc2Cl)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	136086828	7193	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	502	7	3	7	3.9	C[C@H]1CC(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)=C(C(=O)O)C[C@H]1c1cc(F)cc(F)c1F	10.1016/j.bmcl.2010.04.001
	CHEMBL1085589	7193	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	502	7	3	7	3.9	C[C@H]1CC(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)=C(C(=O)O)C[C@H]1c1cc(F)cc(F)c1F	10.1016/j.bmcl.2010.04.001
	135453098	88734	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	402	6	3	5	4.4	O=C(CCc1cnc(-c2ccc(O)cc2Cl)s1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	CHEMBL236162	88734	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	402	6	3	5	4.4	O=C(CCc1cnc(-c2ccc(O)cc2Cl)s1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	56950369	3559	13	None	-3	4	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	8469	3559	13	None	-3	4	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	CHEMBL2036958	3559	13	None	-3	4	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	DB12433	3559	13	None	-3	4	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse GPR109aAgonist activity at mouse GPR109a	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	24955646	58034	0	None	2	4	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	310	5	1	4	2.9	CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	CHEMBL1672639	58034	0	None	2	4	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	310	5	1	4	2.9	CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	42625474	184178	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	380	5	3	5	3.6	O=C(CCc1noc2c1ccc1cc(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
	CHEMBL483139	184178	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	380	5	3	5	3.6	O=C(CCc1noc2c1ccc1cc(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
	11624691	7227	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	361	6	3	3	4.3	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	CHEMBL1085711	7227	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	361	6	3	3	4.3	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	136127010	16086	11	None	9	2	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat GPR109A receptor assessed as GTPgammaS bindingAgonist activity at rat GPR109A receptor assessed as GTPgammaS binding	ChEMBL	215	0	1	3	1.3	O=c1[nH]c(C(F)(F)F)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	CHEMBL1223819	16086	11	None	9	2	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat GPR109A receptor assessed as GTPgammaS bindingAgonist activity at rat GPR109A receptor assessed as GTPgammaS binding	ChEMBL	215	0	1	3	1.3	O=c1[nH]c(C(F)(F)F)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	882926	85607	13	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	301	6	2	4	2.4	COc1ccc(OCC(=O)Nc2ccccc2C(=O)O)cc1	10.1021/jm700942d
	CHEMBL228244	85607	13	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	301	6	2	4	2.4	COc1ccc(OCC(=O)Nc2ccccc2C(=O)O)cc1	10.1021/jm700942d
	882926	85607	13	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	301	6	2	4	2.4	COc1ccc(OCC(=O)Nc2ccccc2C(=O)O)cc1	10.1021/jm900151e
	CHEMBL228244	85607	13	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	301	6	2	4	2.4	COc1ccc(OCC(=O)Nc2ccccc2C(=O)O)cc1	10.1021/jm900151e
	44580008	186948	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	414	7	1	5	4.6	Cc1c(C(=O)NCCOc2ccccc2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
	CHEMBL490216	186948	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	414	7	1	5	4.6	Cc1c(C(=O)NCCOc2ccccc2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
	53318740	58052	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	238	2	1	4	1.5	CCc1cc(=O)oc2nc(C(C)F)[nH]c(=O)c12	10.1021/ml100251u
	CHEMBL1672746	58052	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	238	2	1	4	1.5	CCc1cc(=O)oc2nc(C(C)F)[nH]c(=O)c12	10.1021/ml100251u
	11322762	137602	1	None	5	2	Human	5.2	pEC50	=	5.2	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2c(F)cccc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL375625	137602	1	None	5	2	Human	5.2	pEC50	=	5.2	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2c(F)cccc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	17925840	93621	17	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	140	2	2	3	-0.1	O=Cc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.06.028
	CHEMBL246692	93621	17	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	140	2	2	3	-0.1	O=Cc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.06.028
	70683894	75241	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	298	4	2	4	1.3	O=c1[nH]c(=O)c2c(CCCc3ccccc3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036822	75241	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	298	4	2	4	1.3	O=c1[nH]c(=O)c2c(CCCc3ccccc3)cc(=O)oc2[nH]1	10.1021/ml200243g
	15986930	184910	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	371	5	3	6	2.8	O=C(CCc1cn2c(n1)sc1cc(O)ccc12)NC1=C(C(=O)O)CCC1	10.1021/jm900151e
	CHEMBL485327	184910	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	371	5	3	6	2.8	O=C(CCc1cn2c(n1)sc1cc(O)ccc12)NC1=C(C(=O)O)CCC1	10.1021/jm900151e
	11776293	149257	8	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	236	3	2	2	2.4	O=C(O)c1cc(Cc2cccc(Cl)c2)n[nH]1	10.1016/j.bmcl.2007.06.028
	CHEMBL394441	149257	8	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	236	3	2	2	2.4	O=C(O)c1cc(Cc2cccc(Cl)c2)n[nH]1	10.1016/j.bmcl.2007.06.028
	56950649	69937	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	331	5	1	7	1.9	CCc1noc(C)c1COc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939032	69937	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	331	5	1	7	1.9	CCc1noc(C)c1COc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	137653428	158543	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	315	4	2	2	3.0	O=C(CCC#Cc1ccc(F)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4091542	158543	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	315	4	2	2	3.0	O=C(CCC#Cc1ccc(F)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	44445341	154248	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	376	4	2	5	3.2	O=C(O)c1ccccc1NC(=O)C1CCN(c2cnc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
	CHEMBL398625	154248	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	376	4	2	5	3.2	O=C(O)c1ccccc1NC(=O)C1CCN(c2cnc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
	90645409	112532	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	386	5	2	4	3.9	COc1ccc2nc(Cl)c(/C=C/C(=O)NC3=C(C(=O)O)CCCC3)cc2c1	10.1016/j.bmc.2014.05.011
	CHEMBL3299112	112532	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	386	5	2	4	3.9	COc1ccc2nc(Cl)c(/C=C/C(=O)NC3=C(C(=O)O)CCCC3)cc2c1	10.1016/j.bmc.2014.05.011
	1047	202636	130	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	124	1	1	3	0.2	O=C(O)c1cnccn1	10.1016/j.bmcl.2007.06.028
	CHEMBL613	202636	130	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	124	1	1	3	0.2	O=C(O)c1cnccn1	10.1016/j.bmcl.2007.06.028
	11494579	1058	0	None	123	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	377	5	3	5	2.9	O=C(Nc1ccccc1C(=O)O)CCc1cnn2c1CCc1c2ccc(c1)O	10.1021/jm900151e
	5791	1058	0	None	123	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	377	5	3	5	2.9	O=C(Nc1ccccc1C(=O)O)CCc1cnn2c1CCc1c2ccc(c1)O	10.1021/jm900151e
	CHEMBL482768	1058	0	None	123	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	377	5	3	5	2.9	O=C(Nc1ccccc1C(=O)O)CCc1cnn2c1CCc1c2ccc(c1)O	10.1021/jm900151e
	24811550	6680	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	434	6	3	4	4.4	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccc(F)nc2)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1083450	6680	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	434	6	3	4	4.4	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccc(F)nc2)CC1	10.1016/j.bmcl.2010.04.001
	156021045	178131	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	399	9	3	8	2.7	CCCCn1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
	CHEMBL4648435	178131	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	399	9	3	8	2.7	CCCCn1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
	135887289	6921	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	386	6	3	7	2.5	CC(C)(CC(=O)NC1=C(C(=O)O)CCCC1)c1nc(-c2ccc(O)cn2)no1	10.1021/jm100022r
	CHEMBL1084394	6921	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	386	6	3	7	2.5	CC(C)(CC(=O)NC1=C(C(=O)O)CCCC1)c1nc(-c2ccc(O)cn2)no1	10.1021/jm100022r
	54580748	61398	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	377	5	3	5	2.9	O=C(CCc1cc2n(n1)-c1ccc(O)cc1CC2)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	CHEMBL1770173	61398	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	377	5	3	5	2.9	O=C(CCc1cc2n(n1)-c1ccc(O)cc1CC2)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	53321367	58053	1	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	228	1	1	4	1.1	Cc1cc(=O)oc2nc(C(F)F)[nH]c(=O)c12	10.1021/ml100251u
	CHEMBL1672748	58053	1	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	228	1	1	4	1.1	Cc1cc(=O)oc2nc(C(F)F)[nH]c(=O)c12	10.1021/ml100251u
	11379903	84271	0	None	6	2	Human	7.2	pEC50	=	7.2	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL221282	84271	0	None	6	2	Human	7.2	pEC50	=	7.2	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	24953855	69950	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	316	5	1	5	2.3	CCC#CCOc1nc2oc(=O)cc(CCC(C)C)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939045	69950	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	316	5	1	5	2.3	CCC#CCOc1nc2oc(=O)cc(CCC(C)C)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	44441316	93790	1	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	194	3	2	2	1.9	CCCC1CCc2c1n[nH]c2C(=O)O	10.1016/j.bmcl.2007.06.028
	CHEMBL247526	93790	1	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	194	3	2	2	1.9	CCCC1CCc2c1n[nH]c2C(=O)O	10.1016/j.bmcl.2007.06.028
	24953853	69954	0	None	1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	328	6	1	5	2.4	CCC#CCOc1nc2oc(=O)cc(CCCC3CC3)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939049	69954	0	None	1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	328	6	1	5	2.4	CCC#CCOc1nc2oc(=O)cc(CCCC3CC3)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	117629482	2823	140	None	-3	4	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assayAgonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
	1588	2823	140	None	-3	4	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assayAgonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
	1594	2823	140	None	-3	4	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assayAgonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
	2835	2823	140	None	-3	4	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assayAgonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
	938	2823	140	None	-3	4	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assayAgonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
	CHEMBL573	2823	140	None	-3	4	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assayAgonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
	DB00627	2823	140	None	-3	4	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assayAgonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
	90645408	112535	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	329	4	2	4	2.5	O=C(/C=C/c1ccc2c(c1)OCCO2)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	CHEMBL3299115	112535	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	329	4	2	4	2.5	O=C(/C=C/c1ccc2c(c1)OCCO2)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	42625213	192303	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	365	5	2	5	3.8	O=C(CCc1cn2c(n1)sc1ccccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
	CHEMBL520620	192303	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	365	5	2	5	3.8	O=C(CCc1cn2c(n1)sc1ccccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
	59343597	75265	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	296	4	2	4	1.3	O=c1[nH]c(=O)c2c(CCCC3(Cl)CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036960	75265	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	296	4	2	4	1.3	O=c1[nH]c(=O)c2c(CCCC3(Cl)CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	57412301	76106	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	218	3	2	2	1.8	O=C(O)c1n[nH]c2c1C[C@H]1[C@@H](CC3CC3)[C@@H]21	10.1021/jm2010964
	CHEMBL2057602	76106	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	218	3	2	2	1.8	O=C(O)c1n[nH]c2c1C[C@H]1[C@@H](CC3CC3)[C@@H]21	10.1021/jm2010964
	122181142	121830	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	365	6	3	3	4.0	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL3589836	121830	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	365	6	3	3	4.0	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	44579762	187159	1	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	428	7	1	5	5.0	Cc1c(C(=O)NC(C)COc2ccccc2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
	CHEMBL492020	187159	1	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	428	7	1	5	5.0	Cc1c(C(=O)NC(C)COc2ccccc2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
	11415838	136357	0	None	1	2	Human	5.2	pEC50	=	5.2	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	316	2	1	4	2.6	Cc1sc(C2(C)OC(C(=O)O)=CC2=O)cc1Br	10.1021/jm070022x
	CHEMBL373484	136357	0	None	1	2	Human	5.2	pEC50	=	5.2	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	316	2	1	4	2.6	Cc1sc(C2(C)OC(C(=O)O)=CC2=O)cc1Br	10.1021/jm070022x
	137661033	159487	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	313	4	3	3	2.6	O=C(CCC#Cc1ccccc1O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4101720	159487	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	313	4	3	3	2.6	O=C(CCC#Cc1ccccc1O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	11470798	137967	1	None	2	2	Human	5.1	pEC50	=	5.1	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)c(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL376419	137967	1	None	2	2	Human	5.1	pEC50	=	5.1	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)c(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	156020475	178074	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	429	8	3	5	4.5	CCCCc1nc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)n1C	10.1016/j.bmcl.2020.127105
	CHEMBL4647545	178074	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	429	8	3	5	4.5	CCCCc1nc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)n1C	10.1016/j.bmcl.2020.127105
	136088961	61450	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	387	6	4	8	1.0	CC1CCC(NC(=O)[C@@H](N)Cc2nc(-c3ccc(O)cn3)no2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.11.116
	CHEMBL1770357	61450	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	387	6	4	8	1.0	CC1CCC(NC(=O)[C@@H](N)Cc2nc(-c3ccc(O)cn3)no2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.11.116
	57397202	69933	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	399	5	1	6	3.6	CCc1cc(=O)oc2nc(OCc3cccc(-c4cccc(C#N)c4)c3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939028	69933	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	399	5	1	6	3.6	CCc1cc(=O)oc2nc(OCc3cccc(-c4cccc(C#N)c4)c3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	135887288	7616	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	398	6	3	7	2.6	O=C(O)C1=C(NC(=O)C2(Cc3nc(-c4ccc(O)cn4)no3)CCC2)CCCC1	10.1021/jm100022r
	CHEMBL1088074	7616	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAgonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	398	6	3	7	2.6	O=C(O)C1=C(NC(=O)C2(Cc3nc(-c4ccc(O)cn4)no3)CCC2)CCCC1	10.1021/jm100022r
	135922719	184287	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	377	5	3	5	3.0	Cn1nc(CCC(=O)Nc2ccccc2C(=O)O)c2c1-c1ccc(O)cc1C2	10.1021/jm900151e
	CHEMBL483996	184287	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	377	5	3	5	3.0	Cn1nc(CCC(=O)Nc2ccccc2C(=O)O)c2c1-c1ccc(O)cc1C2	10.1021/jm900151e
	15605503	69935	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	299	4	1	6	1.4	CCc1cc(=O)oc2nc(OCc3cccnc3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939030	69935	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	299	4	1	6	1.4	CCc1cc(=O)oc2nc(OCc3cccnc3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	135502978	191989	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	377	5	4	4	3.2	O=C(CCc1[nH]nc2c1CCc1cc(O)ccc1-2)Nc1ccccc1C(=O)O	10.1021/jm900151e
	CHEMBL520136	191989	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	377	5	4	4	3.2	O=C(CCc1[nH]nc2c1CCc1cc(O)ccc1-2)Nc1ccccc1C(=O)O	10.1021/jm900151e
	11324121	84666	0	None	5	2	Human	6.1	pEC50	=	6.1	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	CC1(c2cc(Br)cs2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL222472	84666	0	None	5	2	Human	6.1	pEC50	=	6.1	Functional	Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	CC1(c2cc(Br)cs2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	46890579	7016	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	455	7	2	7	3.2	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CC(c2ccc(F)nc2)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1084798	7016	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	455	7	2	7	3.2	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CC(c2ccc(F)nc2)CC1	10.1016/j.bmcl.2010.04.001
	46890580	7017	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	504	7	2	6	4.3	C[C@H]1CC(NC(=O)CCc2nc(-c3ccc(F)cn3)no2)=C(C(=O)O)C[C@H]1c1cc(F)cc(F)c1F	10.1016/j.bmcl.2010.04.001
	CHEMBL1084799	7017	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	504	7	2	6	4.3	C[C@H]1CC(NC(=O)CCc2nc(-c3ccc(F)cn3)no2)=C(C(=O)O)C[C@H]1c1cc(F)cc(F)c1F	10.1016/j.bmcl.2010.04.001
	44433532	152409	0	None	16	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	2	2	4	0.3	CCc1[nH]nc(-c2nnn[nH]2)c1F	10.1016/j.bmcl.2007.07.101
	CHEMBL397055	152409	0	None	16	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	2	2	4	0.3	CCc1[nH]nc(-c2nnn[nH]2)c1F	10.1016/j.bmcl.2007.07.101
	15986931	192236	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	385	5	3	6	3.2	O=C(CCc1cn2c(n1)sc1cc(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
	CHEMBL520513	192236	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	385	5	3	6	3.2	O=C(CCc1cn2c(n1)sc1cc(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
	15986755	184118	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	339	5	3	3	3.5	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.001
	CHEMBL482698	184118	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	339	5	3	3	3.5	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.001
	156021546	178186	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	401	9	4	9	1.3	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1cn(CCCO)cc1C(=O)O	10.1016/j.bmcl.2020.127105
	CHEMBL4649305	178186	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	401	9	4	9	1.3	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1cn(CCCO)cc1C(=O)O	10.1016/j.bmcl.2020.127105
	247986	150180	129	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	157	1	1	2	1.4	O=C(O)c1cncc(Cl)c1	10.1016/j.bmcl.2007.06.028
	CHEMBL395178	150180	129	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	157	1	1	2	1.4	O=C(O)c1cncc(Cl)c1	10.1016/j.bmcl.2007.06.028
	11647028	88682	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	401	6	3	4	5.0	O=C(CCc1ccc(-c2ccc(O)cc2Cl)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	CHEMBL235954	88682	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	401	6	3	4	5.0	O=C(CCc1ccc(-c2ccc(O)cc2Cl)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	574310	18956	148	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	112	1	2	2	0.1	O=C(O)c1cc[nH]n1	10.1016/j.bmcl.2007.07.101
	CHEMBL128679	18956	148	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	112	1	2	2	0.1	O=C(O)c1cc[nH]n1	10.1016/j.bmcl.2007.07.101
	44433528	147522	0	None	-10	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	178	3	2	4	0.5	CCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL393064	147522	0	None	-10	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	178	3	2	4	0.5	CCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	117629482	2823	140	None	-4	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml3000676
	1588	2823	140	None	-4	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml3000676
	1594	2823	140	None	-4	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml3000676
	2835	2823	140	None	-4	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml3000676
	938	2823	140	None	-4	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml3000676
	CHEMBL573	2823	140	None	-4	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml3000676
	DB00627	2823	140	None	-4	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml3000676
	16048993	168977	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	377	3	2	5	2.7	O=C(O)c1ccccc1NC(=O)N1CCN(c2ncc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
	CHEMBL439060	168977	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	377	3	2	5	2.7	O=C(O)c1ccccc1NC(=O)N1CCN(c2ncc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
	53324034	58037	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	338	6	1	4	3.6	CC(C)C1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	CHEMBL1672641	58037	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	338	6	1	4	3.6	CC(C)C1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	10197980	88489	2	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	186	4	2	2	1.6	CCCCc1[nH]nc(C(=O)O)c1F	10.1016/j.bmcl.2007.07.101
	CHEMBL235009	88489	2	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	186	4	2	2	1.6	CCCCc1[nH]nc(C(=O)O)c1F	10.1016/j.bmcl.2007.07.101
	4913402	149322	74	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	140	2	2	2	0.7	CCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.07.101
	CHEMBL394498	149322	74	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	140	2	2	2	0.7	CCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.07.101
	16048845	167175	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	420	4	3	6	1.8	NC(=O)c1ccc2ncc(N3CCN(C(=O)Nc4ccccc4C(=O)O)CC3)nc2c1	10.1016/j.bmcl.2007.10.055
	CHEMBL429120	167175	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	420	4	3	6	1.8	NC(=O)c1ccc2ncc(N3CCN(C(=O)Nc4ccccc4C(=O)O)CC3)nc2c1	10.1016/j.bmcl.2007.10.055
	56950369	3559	13	None	-3	4	Rat	8.1	pEC50	=	8.1	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	8469	3559	13	None	-3	4	Rat	8.1	pEC50	=	8.1	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	CHEMBL2036958	3559	13	None	-3	4	Rat	8.1	pEC50	=	8.1	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	DB12433	3559	13	None	-3	4	Rat	8.1	pEC50	=	8.1	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	15605571	75235	2	None	1	5	Rat	8.1	pEC50	=	8.1	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	236	3	2	4	0.5	CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036813	75235	2	None	1	5	Rat	8.1	pEC50	=	8.1	Functional	Agonist activity at rat GPR109aAgonist activity at rat GPR109a	ChEMBL	236	3	2	4	0.5	CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	117629482	2823	140	None	-4	4	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	1588	2823	140	None	-4	4	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	1594	2823	140	None	-4	4	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	2835	2823	140	None	-4	4	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	938	2823	140	None	-4	4	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	CHEMBL573	2823	140	None	-4	4	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	DB00627	2823	140	None	-4	4	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	137635425	155922	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	331	4	3	3	2.7	O=C(CCC#Cc1ccc(O)cc1F)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4060899	155922	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	331	4	3	3	2.7	O=C(CCC#Cc1ccc(O)cc1F)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	4913402	149322	74	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	140	2	2	2	0.7	CCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.06.028
	CHEMBL394498	149322	74	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	140	2	2	2	0.7	CCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.06.028
	57413450	76471	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	220	3	2	2	2.0	CC(C)C[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	CHEMBL2059821	76471	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	220	3	2	2	2.0	CC(C)C[C@@H]1[C@@H]2Cc3c(C(=O)O)n[nH]c3[C@@H]21	10.1021/jm2010964
	156022048	178201	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	383	7	3	8	2.2	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1cn(C2CC2)cc1C(=O)O	10.1016/j.bmcl.2020.127105
	CHEMBL4649587	178201	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	383	7	3	8	2.2	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1cn(C2CC2)cc1C(=O)O	10.1016/j.bmcl.2020.127105
	53317491	58043	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	282	3	1	4	2.2	O=c1cc(CC2CCC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1672735	58043	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	282	3	1	4	2.2	O=c1cc(CC2CCC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	57413545	76109	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	224	3	2	3	1.4	CSC[C@H]1[C@H]2c3[nH]nc(C(=O)O)c3C[C@H]21	10.1021/jm2010964
	CHEMBL2057605	76109	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	224	3	2	3	1.4	CSC[C@H]1[C@H]2c3[nH]nc(C(=O)O)c3C[C@H]21	10.1021/jm2010964
	24953853	69954	0	None	-1	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat nicotinic acid receptorAgonist activity at rat nicotinic acid receptor	ChEMBL	328	6	1	5	2.4	CCC#CCOc1nc2oc(=O)cc(CCCC3CC3)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939049	69954	0	None	-1	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat nicotinic acid receptorAgonist activity at rat nicotinic acid receptor	ChEMBL	328	6	1	5	2.4	CCC#CCOc1nc2oc(=O)cc(CCCC3CC3)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	11845295	149578	42	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity against human GPR109a assessed as forskolin-induced cAMP accumulationAgonist activity against human GPR109a assessed as forskolin-induced cAMP accumulation	ChEMBL	166	1	2	2	1.2	CC1CCc2c(C(=O)O)n[nH]c21	10.1021/jm800258p
	CHEMBL394688	149578	42	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity against human GPR109a assessed as forskolin-induced cAMP accumulationAgonist activity against human GPR109a assessed as forskolin-induced cAMP accumulation	ChEMBL	166	1	2	2	1.2	CC1CCc2c(C(=O)O)n[nH]c21	10.1021/jm800258p
	15986754	184490	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	323	5	2	2	3.8	O=C(CCc1ccc2ccccc2c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	CHEMBL484719	184490	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	323	5	2	2	3.8	O=C(CCc1ccc2ccccc2c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	776421	89928	108	None	30	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	154	2	2	2	1.2	CC(C)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.06.028
	CHEMBL238002	89928	108	None	30	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	154	2	2	2	1.2	CC(C)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.06.028
	11845295	149578	42	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	166	1	2	2	1.2	CC1CCc2c(C(=O)O)n[nH]c21	10.1016/j.bmcl.2007.06.028
	CHEMBL394688	149578	42	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	166	1	2	2	1.2	CC1CCc2c(C(=O)O)n[nH]c21	10.1016/j.bmcl.2007.06.028
	135922722	184191	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	391	5	3	5	3.2	Cn1nc(CCC(=O)Nc2ccccc2C(=O)O)c2c1-c1ccc(O)cc1CC2	10.1021/jm900151e
	CHEMBL483160	184191	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay	ChEMBL	391	5	3	5	3.2	Cn1nc(CCC(=O)Nc2ccccc2C(=O)O)c2c1-c1ccc(O)cc1CC2	10.1021/jm900151e
	57412301	76106	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	218	3	2	2	1.8	O=C(O)c1n[nH]c2c1C[C@H]1[C@@H](CC3CC3)[C@@H]21	10.1021/jm2010964
	CHEMBL2057602	76106	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	218	3	2	2	1.8	O=C(O)c1n[nH]c2c1C[C@H]1[C@@H](CC3CC3)[C@@H]21	10.1021/jm2010964
	136000580	61449	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	387	6	4	8	1.0	C[C@@H]1CCC(C(=O)O)=C(NC(=O)[C@@H](N)Cc2nc(-c3ccc(O)cn3)no2)C1	10.1016/j.bmcl.2010.11.116
	CHEMBL1770356	61449	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	387	6	4	8	1.0	C[C@@H]1CCC(C(=O)O)=C(NC(=O)[C@@H](N)Cc2nc(-c3ccc(O)cn3)no2)C1	10.1016/j.bmcl.2010.11.116
	1591	131	63	None	33	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.07.101
	6485181	131	63	None	33	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.07.101
	CHEMBL428730	131	63	None	33	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.07.101
	57412303	76110	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	224	3	2	3	1.4	CSC[C@@H]1[C@H]2c3[nH]nc(C(=O)O)c3C[C@@H]12	10.1021/jm2010964
	CHEMBL2057606	76110	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayAgonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay	ChEMBL	224	3	2	3	1.4	CSC[C@@H]1[C@H]2c3[nH]nc(C(=O)O)c3C[C@@H]12	10.1021/jm2010964
	11617480	88681	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	362	6	3	4	3.7	O=C(CCc1ccc(-c2ccc(O)cn2)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	CHEMBL235952	88681	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	362	6	3	4	3.7	O=C(CCc1ccc(-c2ccc(O)cn2)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	776416	18938	108	None	-5	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity against human GPR109a assessed as forskolin-induced cAMP accumulationAgonist activity against human GPR109a assessed as forskolin-induced cAMP accumulation	ChEMBL	152	1	2	2	0.6	O=C(O)c1n[nH]c2c1CCC2	10.1021/jm800258p
	CHEMBL128604	18938	108	None	-5	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity against human GPR109a assessed as forskolin-induced cAMP accumulationAgonist activity against human GPR109a assessed as forskolin-induced cAMP accumulation	ChEMBL	152	1	2	2	0.6	O=C(O)c1n[nH]c2c1CCC2	10.1021/jm800258p
	57398905	69927	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	328	5	1	6	2.0	CCc1cc(=O)oc2nc(OCc3cccc(OC)c3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939022	69927	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	328	5	1	6	2.0	CCc1cc(=O)oc2nc(OCc3cccc(OC)c3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	776416	18938	108	None	-5	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	152	1	2	2	0.6	O=C(O)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2007.06.028
	CHEMBL128604	18938	108	None	-5	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	152	1	2	2	0.6	O=C(O)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2007.06.028
	44441304	93418	20	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	156	3	2	3	0.3	COCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.06.028
	CHEMBL245858	93418	20	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	156	3	2	3	0.3	COCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.06.028
	44441321	93832	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	182	2	2	3	1.1	CCC1OCc2c1n[nH]c2C(=O)O	10.1016/j.bmcl.2007.06.028
	CHEMBL247723	93832	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	182	2	2	3	1.1	CCC1OCc2c1n[nH]c2C(=O)O	10.1016/j.bmcl.2007.06.028
	136088962	61401	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	368	6	4	7	1.6	N[C@H](Cc1nc(-c2ccc(O)cc2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	CHEMBL1770176	61401	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	368	6	4	7	1.6	N[C@H](Cc1nc(-c2ccc(O)cc2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	11041813	93751	22	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	202	3	2	2	1.7	O=C(O)c1cc(Cc2ccccc2)n[nH]1	10.1016/j.bmcl.2007.06.028
	CHEMBL247317	93751	22	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testAgonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test	ChEMBL	202	3	2	2	1.7	O=C(O)c1cc(Cc2ccccc2)n[nH]1	10.1016/j.bmcl.2007.06.028
	137648386	157772	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	347	4	3	3	3.2	O=C(CCC#Cc1ccc(O)cc1Cl)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	CHEMBL4082765	157772	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at recombinant human HCA2 receptor expressed in Flp-IN HEK cells assessed as reduction in forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL	347	4	3	3	3.2	O=C(CCC#Cc1ccc(O)cc1Cl)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
	24954201	69953	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	314	5	1	5	2.0	CCC#CCOc1nc2oc(=O)cc(CCC3CC3)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939048	69953	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	314	5	1	5	2.0	CCC#CCOc1nc2oc(=O)cc(CCC3CC3)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	90645402	112482	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	335	2	3	3	2.9	O=C(C#Cc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	CHEMBL3298702	112482	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 minsAgonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins	ChEMBL	335	2	3	3	2.9	O=C(C#Cc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2014.05.011
	16048923	94656	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	376	3	2	4	3.3	O=C(O)c1ccccc1NC(=O)N1CCN(c2nccc3ccccc23)CC1	10.1016/j.bmcl.2007.10.055
	CHEMBL252506	94656	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	376	3	2	4	3.3	O=C(O)c1ccccc1NC(=O)N1CCN(c2nccc3ccccc23)CC1	10.1016/j.bmcl.2007.10.055
	15981408	94346	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	405	3	2	5	3.5	C[C@H]1CN(c2cnc3ccccc3n2)C[C@@H](C)N1C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2007.10.055
	CHEMBL250690	94346	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR106A by [35S]GTPgammaS binding assayAgonist activity at human GPR106A by [35S]GTPgammaS binding assay	ChEMBL	405	3	2	5	3.5	C[C@H]1CN(c2cnc3ccccc3n2)C[C@@H](C)N1C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2007.10.055
	57391932	69940	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	246	3	1	5	0.5	C#CCOc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939035	69940	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	246	3	1	5	0.5	C#CCOc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	44250176	1131	0	None	-2951	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	10.1016/j.bmcl.2009.05.108
	5800	1131	0	None	-2951	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	10.1016/j.bmcl.2009.05.108
	CHEMBL564300	1131	0	None	-2951	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	10.1016/j.bmcl.2009.05.108
	24811547	7376	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	415	6	3	3	4.9	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccccc2)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1086355	7376	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	415	6	3	3	4.9	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccccc2)CC1	10.1016/j.bmcl.2010.04.001
	24741307	88735	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	365	6	3	5	3.2	Cc1c(CCC(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cc1	10.1021/jm700942d
	CHEMBL236163	88735	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	365	6	3	5	3.2	Cc1c(CCC(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cc1	10.1021/jm700942d
	57400596	69936	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	300	4	1	7	0.8	CCc1cc(=O)oc2nc(OCc3ccnnc3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	CHEMBL1939031	69936	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	300	4	1	7	0.8	CCc1cc(=O)oc2nc(OCc3ccnnc3)[nH]c(=O)c12	10.1016/j.bmcl.2011.12.041
	11610363	89490	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	369	6	3	6	3.2	O=C(CCc1ncc(-c2ccc(O)cn2)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	CHEMBL237247	89490	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	369	6	3	6	3.2	O=C(CCc1ncc(-c2ccc(O)cn2)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	44579645	187068	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	444	8	1	6	4.6	COc1cccc(OCCNC(=O)c2cnc3c(-c4ccc(C(C)C)cc4)cnn3c2C)c1	10.1016/j.bmcl.2008.08.039
	CHEMBL491227	187068	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	444	8	1	6	4.6	COc1cccc(OCCNC(=O)c2cnc3c(-c4ccc(C(C)C)cc4)cnn3c2C)c1	10.1016/j.bmcl.2008.08.039
	135627640	61397	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	417	6	4	6	3.4	NC(Cc1cnc(-c2ccc(O)cc2Cl)s1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	CHEMBL1770172	61397	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	417	6	4	6	3.4	NC(Cc1cnc(-c2ccc(O)cc2Cl)s1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
	15605292	75238	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	266	3	2	6	-0.7	CCOC(=O)Cc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036819	75238	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	266	3	2	6	-0.7	CCOC(=O)Cc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	11992789	196598	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	343	6	2	3	3.6	O=C(O)c1cc(N(Cc2cccc(F)c2)Cc2cccc(F)c2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL564064	196598	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	343	6	2	3	3.6	O=C(O)c1cc(N(Cc2cccc(F)c2)Cc2cccc(F)c2)[nH]n1	10.1016/j.bmcl.2009.05.108
	46890328	6681	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	484	6	3	4	5.3	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccc(C(F)(F)F)nc2)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1083451	6681	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	484	6	3	4	5.3	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccc(C(F)(F)F)nc2)CC1	10.1016/j.bmcl.2010.04.001
	44579742	187044	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	347	6	2	3	3.9	O=Cc1ccc2cc(CCC(=O)Nc3ccccc3C(=O)O)ccc2c1	10.1016/j.bmcl.2008.08.030
	CHEMBL491003	187044	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayAgonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay	ChEMBL	347	6	2	3	3.9	O=Cc1ccc2cc(CCC(=O)Nc3ccccc3C(=O)O)ccc2c1	10.1016/j.bmcl.2008.08.030
	136375455	177554	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	385	7	3	8	2.5	CC(C)n1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
	CHEMBL4640349	177554	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysisAgonist activity at GPR109A receptor (unknown origin) expressed in HEK293T cell membranes after 30 mins by [35S]GTPgammaS binding based microbeta scintillation counting analysis	ChEMBL	385	7	3	8	2.5	CC(C)n1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
	57395377	69942	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	274	3	1	5	1.2	CCC#CCOc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	CHEMBL1939037	69942	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human HM74AAgonist activity at human HM74A	ChEMBL	274	3	1	5	1.2	CCC#CCOc1nc2oc(=O)cc(CC)c2c(=O)[nH]1	10.1016/j.bmcl.2011.12.041
	11566404	145671	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	346	6	2	3	4.0	O=C(CCc1ccc(-c2ccccn2)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	CHEMBL391603	145671	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assayAgonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTP-gamma-S binding assay	ChEMBL	346	6	2	3	4.0	O=C(CCc1ccc(-c2ccccn2)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
	136086824	6843	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	453	7	3	8	2.7	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CC(c2ccc(F)nc2)CC1	10.1016/j.bmcl.2010.04.001
	CHEMBL1084031	6843	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayAgonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay	ChEMBL	453	7	3	8	2.7	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CC(c2ccc(F)nc2)CC1	10.1016/j.bmcl.2010.04.001
	117629482	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	1588	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	1594	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	2835	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	938	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	CHEMBL573	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	DB00627	2823	140	None	-4	4	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/ml200243g
	59304624	75234	2	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	222	2	2	4	0.1	CCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036812	75234	2	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	222	2	2	4	0.1	CCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	13557	1106	111	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	127	1	1	3	0.7	CC1=NOC(=C1)C(=O)O	10.1074/jbc.m701866200
	853085	1106	111	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	127	1	1	3	0.7	CC1=NOC(=C1)C(=O)O	10.1074/jbc.m701866200
	CHEMBL393428	1106	111	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	127	1	1	3	0.7	CC1=NOC(=C1)C(=O)O	10.1074/jbc.m701866200
	11550911	95188	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	280	3	2	2	2.5	O=C(O)c1cc(Cc2cccc(Br)c2)[nH]n1	10.1074/jbc.m701866200
	CHEMBL255877	95188	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	280	3	2	2	2.5	O=C(O)c1cc(Cc2cccc(Br)c2)[nH]n1	10.1074/jbc.m701866200
	11557600	167382	1	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	220	3	2	2	1.8	O=C(O)c1cc(Cc2cccc(F)c2)[nH]n1	10.1074/jbc.m701866200
	CHEMBL429495	167382	1	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	220	3	2	2	1.8	O=C(O)c1cc(Cc2cccc(F)c2)[nH]n1	10.1074/jbc.m701866200
	776421	89928	108	None	30	2	Human	5.6	pIC50	=	5.6	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	154	2	2	2	1.2	CC(C)c1cc(C(=O)O)n[nH]1	10.1074/jbc.m701866200
	CHEMBL238002	89928	108	None	30	2	Human	5.6	pIC50	=	5.6	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	154	2	2	2	1.2	CC(C)c1cc(C(=O)O)n[nH]1	10.1074/jbc.m701866200
	11776293	149257	8	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	236	3	2	2	2.4	O=C(O)c1cc(Cc2cccc(Cl)c2)n[nH]1	10.1074/jbc.m701866200
	CHEMBL394441	149257	8	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	236	3	2	2	2.4	O=C(O)c1cc(Cc2cccc(Cl)c2)n[nH]1	10.1074/jbc.m701866200
	1595	259	49	None	4	2	Human	6.3	pIC50	=	6.3	Functional	Activity at GPR109a assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109a assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	51576	259	49	None	4	2	Human	6.3	pIC50	=	6.3	Functional	Activity at GPR109a assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109a assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	CHEMBL278488	259	49	None	4	2	Human	6.3	pIC50	=	6.3	Functional	Activity at GPR109a assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109a assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	117629482	2823	140	None	-4	4	Human	4.2	pIC50	=	4.2	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1074/jbc.m701866200
	1588	2823	140	None	-4	4	Human	4.2	pIC50	=	4.2	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1074/jbc.m701866200
	1594	2823	140	None	-4	4	Human	4.2	pIC50	=	4.2	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1074/jbc.m701866200
	2835	2823	140	None	-4	4	Human	4.2	pIC50	=	4.2	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1074/jbc.m701866200
	938	2823	140	None	-4	4	Human	4.2	pIC50	=	4.2	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1074/jbc.m701866200
	CHEMBL573	2823	140	None	-4	4	Human	4.2	pIC50	=	4.2	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1074/jbc.m701866200
	DB00627	2823	140	None	-4	4	Human	4.2	pIC50	=	4.2	Functional	Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assayAgonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1074/jbc.m701866200
	108	111	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	137	2	1	2	0.7	OC(=O)Cc1cccnc1	None
	1590	111	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	137	2	1	2	0.7	OC(=O)Cc1cccnc1	None
	3505	111	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	137	2	1	2	0.7	OC(=O)Cc1cccnc1	None
	CHEMBL1741437	111	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	137	2	1	2	0.7	OC(=O)Cc1cccnc1	None
	1596	260	96	None	-	1	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	None
	5310993	260	96	None	-	1	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	None
	76	260	96	None	-	1	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	None
	CHEMBL345714	260	96	None	-	1	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	None
	DB09055	260	96	None	-	1	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	None
	13558	1041	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at HCAR2, determined in a [<sup>35</sup>S]-GTP&gammagS binding assayAgonist activity at HCAR2, determined in a [<sup>35</sup>S]-GTP&gammagS binding assay	Guide to Pharmacology	242	3	2	4	0.9	C(CCC)N1C(NC(C=2NC(=NC12)Cl)=O)=O	None
	59299562	1041	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at HCAR2, determined in a [<sup>35</sup>S]-GTP&gammagS binding assayAgonist activity at HCAR2, determined in a [<sup>35</sup>S]-GTP&gammagS binding assay	Guide to Pharmacology	242	3	2	4	0.9	C(CCC)N1C(NC(C=2NC(=NC12)Cl)=O)=O	None
	CHEMBL3732182	1041	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at HCAR2, determined in a [<sup>35</sup>S]-GTP&gammagS binding assayAgonist activity at HCAR2, determined in a [<sup>35</sup>S]-GTP&gammagS binding assay	Guide to Pharmacology	242	3	2	4	0.9	C(CCC)N1C(NC(C=2NC(=NC12)Cl)=O)=O	None
	13559	1135	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at HCAR2, determined in a [<sup>35</sup>S]-GTP&gammagS binding assayAgonist activity at HCAR2, determined in a [<sup>35</sup>S]-GTP&gammagS binding assay	Guide to Pharmacology	460	9	1	9	2.1	C(CCC)N1C(N(C(C=2NC(=NC12)Cl)=O)CCCN3N=C(N=N3)CC4=CC=C(C=C4)F)=O	None
	59395852	1135	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at HCAR2, determined in a [<sup>35</sup>S]-GTP&gammagS binding assayAgonist activity at HCAR2, determined in a [<sup>35</sup>S]-GTP&gammagS binding assay	Guide to Pharmacology	460	9	1	9	2.1	C(CCC)N1C(N(C(C=2NC(=NC12)Cl)=O)CCCN3N=C(N=N3)CC4=CC=C(C=C4)F)=O	None
	1059	750	81	None	-67	3	Human	2.8	pEC50	=	2.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	None
	264	750	81	None	-67	3	Human	2.8	pEC50	=	2.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	None
	CHEMBL14227	750	81	None	-67	3	Human	2.8	pEC50	=	2.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	None
	DB03568	750	81	None	-67	3	Human	2.8	pEC50	=	2.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	None
	1593	609	0	None	-2	2	Human	3.1	pEC50	=	3.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	104	2	2	2	-0.2	C[C@H](CC(=O)O)O	15929991
	92135	609	0	None	-2	2	Human	3.1	pEC50	=	3.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	104	2	2	2	-0.2	C[C@H](CC(=O)O)O	15929991
	CHEMBL1162484	609	0	None	-2	2	Human	3.1	pEC50	=	3.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	104	2	2	2	-0.2	C[C@H](CC(=O)O)O	15929991
	5787	3005	119	None	-	1	Human	3.5	pEC50	=	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	164	2	2	2	1.5	OC(=O)/C=C/c1ccc(cc1)O	19136666
	637542	3005	119	None	-	1	Human	3.5	pEC50	=	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	164	2	2	2	1.5	OC(=O)/C=C/c1ccc(cc1)O	19136666
	CHEMBL66879	3005	119	None	-	1	Human	3.5	pEC50	=	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	164	2	2	2	1.5	OC(=O)/C=C/c1ccc(cc1)O	19136666
	DB04066	3005	119	None	-	1	Human	3.5	pEC50	=	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	164	2	2	2	1.5	OC(=O)/C=C/c1ccc(cc1)O	19136666
	3203	939	111	None	-	1	Human	3.6	pEC50	=	3.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	148	2	1	1	1.8	OC(=O)/C=C/c1ccccc1	19136666
	444539	939	111	None	-	1	Human	3.6	pEC50	=	3.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	148	2	1	1	1.8	OC(=O)/C=C/c1ccccc1	19136666
	CHEMBL27246	939	111	None	-	1	Human	3.6	pEC50	=	3.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	148	2	1	1	1.8	OC(=O)/C=C/c1ccccc1	19136666
	5369209	2591	81	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	130	2	1	3	-0.2	COC(=O)/C=C/C(=O)O	18722346
	5786	2591	81	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	130	2	1	3	-0.2	COC(=O)/C=C/C(=O)O	18722346
	CHEMBL589586	2591	81	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	130	2	1	3	-0.2	COC(=O)/C=C/C(=O)O	18722346
	DB14219	2591	81	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	130	2	1	3	-0.2	COC(=O)/C=C/C(=O)O	18722346
	1596	260	96	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	12522134
	1596	260	96	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	12646212
	5310993	260	96	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	12522134
	5310993	260	96	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	12646212
	76	260	96	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	12522134
	76	260	96	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	12646212
	CHEMBL345714	260	96	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	12522134
	CHEMBL345714	260	96	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	12646212
	DB09055	260	96	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	12522134
	DB09055	260	96	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	12646212
	5794	1096	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	446	6	1	5	4.3	ClC1CCC(CC1Cl)c1cnn2c1ncc(c2C)C(=O)NCCOc1ccccc1	22420767
	73755156	1096	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	446	6	1	5	4.3	ClC1CCC(CC1Cl)c1cnn2c1ncc(c2C)C(=O)NCCOc1ccccc1	22420767
	11159621	2548	46	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	18665582
	5784	2548	46	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	18665582
	CHEMBL456145	2548	46	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	18665582
	DB05939	2548	46	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	18665582
	117629482	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	117629482	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12563315
	117629482	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12646212
	1588	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	1588	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12563315
	1588	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12646212
	1594	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	1594	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12563315
	1594	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12646212
	2835	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	2835	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12563315
	2835	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12646212
	938	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	938	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12563315
	938	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12646212
	CHEMBL573	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	CHEMBL573	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12563315
	CHEMBL573	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12646212
	DB00627	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	DB00627	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12563315
	DB00627	2823	140	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12646212
	25101223	1152	7	None	-	1	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	428	7	1	5	5.0	C[C@@H](NC(=O)c1cnc2n(c1C)ncc2c1ccc(cc1)C(C)C)COc1ccccc1	18752940
	5795	1152	7	None	-	1	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	428	7	1	5	5.0	C[C@@H](NC(=O)c1cnc2n(c1C)ncc2c1ccc(cc1)C(C)C)COc1ccccc1	18752940
	CHEMBL490599	1152	7	None	-	1	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	428	7	1	5	5.0	C[C@@H](NC(=O)c1cnc2n(c1C)ncc2c1ccc(cc1)C(C)C)COc1ccccc1	18752940
	11672811	1001	5	None	-	1	Human	7.4	pEC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	188	1	2	4	0.2	n1nnc([nH]1)c1n[nH]c2c1CC1C2C1	20363624
	5790	1001	5	None	-	1	Human	7.4	pEC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	188	1	2	4	0.2	n1nnc([nH]1)c1n[nH]c2c1CC1C2C1	20363624
	CHEMBL1169573	1001	5	None	-	1	Human	7.4	pEC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	188	1	2	4	0.2	n1nnc([nH]1)c1n[nH]c2c1CC1C2C1	20363624
	13359	1099	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	442	9	3	7	4.8	CNCCNCC1=CC=CC(=C1)C2=NC(C3=C(C)ON=C3C)=C(C)C(NC4=CC=CC=C4)=N2	None
	146188223	1099	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	442	9	3	7	4.8	CNCCNCC1=CC=CC(=C1)C2=NC(C3=C(C)ON=C3C)=C(C)C(NC4=CC=CC=C4)=N2	None
	46215799	1880	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	4	2	4	1.3	CCCCCn1c(=O)[nH]c(=O)c2c1nc([nH]2)Cl	25773497
	8470	1880	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	4	2	4	1.3	CCCCCn1c(=O)[nH]c(=O)c2c1nc([nH]2)Cl	25773497
	CHEMBL3730241	1880	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	4	2	4	1.3	CCCCCn1c(=O)[nH]c(=O)c2c1nc([nH]2)Cl	25773497
	11607970	2552	10	None	-	1	Human	7.6	pEC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	164	1	2	2	0.8	OC(=O)c1n[nH]c2c1CC1C2C1	22435740
	5785	2552	10	None	-	1	Human	7.6	pEC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	164	1	2	2	0.8	OC(=O)c1n[nH]c2c1CC1C2C1	22435740
	CHEMBL2059221	2552	10	None	-	1	Human	7.6	pEC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	164	1	2	2	0.8	OC(=O)c1n[nH]c2c1CC1C2C1	22435740
	135416394	2560	52	None	15	3	Human	7.8	pEC50	=	7.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	20184326
	5788	2560	52	None	15	3	Human	7.8	pEC50	=	7.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	20184326
	73755154	2560	52	None	15	3	Human	7.8	pEC50	=	7.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	20184326
	CHEMBL1086657	2560	52	None	15	3	Human	7.8	pEC50	=	7.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	20184326
	56950369	3559	13	None	3	4	Human	8.7	pEC50	=	8.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	24900372
	8469	3559	13	None	3	4	Human	8.7	pEC50	=	8.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	24900372
	CHEMBL2036958	3559	13	None	3	4	Human	8.7	pEC50	=	8.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	24900372
	DB12433	3559	13	None	3	4	Human	8.7	pEC50	=	8.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	24900372
	1593	609	0	None	2	2	Mouse	3.5	pEC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	104	2	2	2	-0.2	C[C@H](CC(=O)O)O	15929991
	92135	609	0	None	2	2	Mouse	3.5	pEC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	104	2	2	2	-0.2	C[C@H](CC(=O)O)O	15929991
	CHEMBL1162484	609	0	None	2	2	Mouse	3.5	pEC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	104	2	2	2	-0.2	C[C@H](CC(=O)O)O	15929991
	1592	144	131	None	-	1	Human	5.1	pEC50	None	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	137	1	1	2	1.1	Cc1cc(cnc1)C(=O)O	12522134
	256208	144	131	None	-	1	Human	5.1	pEC50	None	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	137	1	1	2	1.1	Cc1cc(cnc1)C(=O)O	12522134
	CHEMBL247132	144	131	None	-	1	Human	5.1	pEC50	None	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	137	1	1	2	1.1	Cc1cc(cnc1)C(=O)O	12522134
	108	111	0	None	-	1	Human	5.3	pEC50	None	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	137	2	1	2	0.7	OC(=O)Cc1cccnc1	12522134
	1590	111	0	None	-	1	Human	5.3	pEC50	None	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	137	2	1	2	0.7	OC(=O)Cc1cccnc1	12522134
	3505	111	0	None	-	1	Human	5.3	pEC50	None	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	137	2	1	2	0.7	OC(=O)Cc1cccnc1	12522134
	CHEMBL1741437	111	0	None	-	1	Human	5.3	pEC50	None	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	137	2	1	2	0.7	OC(=O)Cc1cccnc1	12522134
	1595	259	49	None	4	2	Human	5.8	pEC50	None	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	12522134
	1595	259	49	None	4	2	Human	5.8	pEC50	None	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	15929991
	1595	259	49	None	4	2	Human	5.8	pEC50	None	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	16389067
	1595	259	49	None	4	2	Human	5.8	pEC50	None	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	17358052
	51576	259	49	None	4	2	Human	5.8	pEC50	None	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	12522134
	51576	259	49	None	4	2	Human	5.8	pEC50	None	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	15929991
	51576	259	49	None	4	2	Human	5.8	pEC50	None	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	16389067
	51576	259	49	None	4	2	Human	5.8	pEC50	None	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	17358052
	CHEMBL278488	259	49	None	4	2	Human	5.8	pEC50	None	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	12522134
	CHEMBL278488	259	49	None	4	2	Human	5.8	pEC50	None	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	15929991
	CHEMBL278488	259	49	None	4	2	Human	5.8	pEC50	None	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	16389067
	CHEMBL278488	259	49	None	4	2	Human	5.8	pEC50	None	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	17358052
	11483496	126	0	None	14	2	Human	7.3	pEC50	None	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	15929991
	11483496	126	0	None	14	2	Human	7.3	pEC50	None	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	17358052
	1589	126	0	None	14	2	Human	7.3	pEC50	None	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	15929991
	1589	126	0	None	14	2	Human	7.3	pEC50	None	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	17358052
	CHEMBL375493	126	0	None	14	2	Human	7.3	pEC50	None	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	15929991
	CHEMBL375493	126	0	None	14	2	Human	7.3	pEC50	None	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	17358052
	53232	188625	95	None	-1	10	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	None
	CHEMBL503	188625	95	None	-1	10	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	None
	13557	1106	111	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of forskolin-stimulated cAMP production in CHO-K1 cells stably transfected with HCAR2.Inhibition of forskolin-stimulated cAMP production in CHO-K1 cells stably transfected with HCAR2.	Guide to Pharmacology	127	1	1	3	0.7	CC1=NOC(=C1)C(=O)O	17452318
	853085	1106	111	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of forskolin-stimulated cAMP production in CHO-K1 cells stably transfected with HCAR2.Inhibition of forskolin-stimulated cAMP production in CHO-K1 cells stably transfected with HCAR2.	Guide to Pharmacology	127	1	1	3	0.7	CC1=NOC(=C1)C(=O)O	17452318
	CHEMBL393428	1106	111	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of forskolin-stimulated cAMP production in CHO-K1 cells stably transfected with HCAR2.Inhibition of forskolin-stimulated cAMP production in CHO-K1 cells stably transfected with HCAR2.	Guide to Pharmacology	127	1	1	3	0.7	CC1=NOC(=C1)C(=O)O	17452318
	12003694	1144	0	None	1	2	Human	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	232	2	2	4	0.7	OC(=O)c1n[nH]c2c1CC(C2)c1ccnn1C	20615702
	5793	1144	0	None	1	2	Human	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	232	2	2	4	0.7	OC(=O)c1n[nH]c2c1CC(C2)c1ccnn1C	20615702
	CHEMBL1208986	1144	0	None	1	2	Human	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	232	2	2	4	0.7	OC(=O)c1n[nH]c2c1CC(C2)c1ccnn1C	20615702
	135401973	1022	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	393	3	3	6	2.4	Oc1ccc2c(c1)ncc(n2)N1CCN(CC1)C(=O)Nc1ccccc1C(=O)O	18029181
	5792	1022	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	393	3	3	6	2.4	Oc1ccc2c(c1)ncc(n2)N1CCN(CC1)C(=O)Nc1ccccc1C(=O)O	18029181
	CHEMBL398496	1022	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	393	3	3	6	2.4	Oc1ccc2c(c1)ncc(n2)N1CCN(CC1)C(=O)Nc1ccccc1C(=O)O	18029181
	11494579	1058	0	None	123	2	Human	7.9	pIC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	377	5	3	5	2.9	O=C(Nc1ccccc1C(=O)O)CCc1cnn2c1CCc1c2ccc(c1)O	19309152
	5791	1058	0	None	123	2	Human	7.9	pIC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	377	5	3	5	2.9	O=C(Nc1ccccc1C(=O)O)CCc1cnn2c1CCc1c2ccc(c1)O	19309152
	CHEMBL482768	1058	0	None	123	2	Human	7.9	pIC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	377	5	3	5	2.9	O=C(Nc1ccccc1C(=O)O)CCc1cnn2c1CCc1c2ccc(c1)O	19309152
	53238781	1027	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	389	6	3	7	1.4	C[C@@H]1CCC(=C(C1)NC(=O)[C@H](Cc1onc(n1)c1ccc(cn1)F)N)C(=O)O	21185185
	5789	1027	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	389	6	3	7	1.4	C[C@@H]1CCC(=C(C1)NC(=O)[C@H](Cc1onc(n1)c1ccc(cn1)F)N)C(=O)O	21185185
	CHEMBL1770358	1027	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	389	6	3	7	1.4	C[C@@H]1CCC(=C(C1)NC(=O)[C@H](Cc1onc(n1)c1ccc(cn1)F)N)C(=O)O	21185185

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		1596	260	96	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HCAR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human HCAR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	10.1038/s41467-023-40064-9
		5310993	260	96	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HCAR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human HCAR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	10.1038/s41467-023-40064-9
		76	260	96	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HCAR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human HCAR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	10.1038/s41467-023-40064-9
		CHEMBL345714	260	96	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HCAR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human HCAR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	10.1038/s41467-023-40064-9
		DB09055	260	96	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HCAR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human HCAR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	154	1	1	3	-0.3	[O-][n+]1cc(ncc1C)C(=O)O	10.1038/s41467-023-40064-9
		117629482	2823	140	None	-3	2	Human	6.0	pEC50	=	6	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.013
		1588	2823	140	None	-3	2	Human	6.0	pEC50	=	6	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.013
		1594	2823	140	None	-3	2	Human	6.0	pEC50	=	6	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.013
		2835	2823	140	None	-3	2	Human	6.0	pEC50	=	6	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.013
		938	2823	140	None	-3	2	Human	6.0	pEC50	=	6	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.013
		CHEMBL573	2823	140	None	-3	2	Human	6.0	pEC50	=	6	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.013
		DB00627	2823	140	None	-3	2	Human	6.0	pEC50	=	6	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.013
		11516424	7315	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	379	6	3	5	3.4	Cc1c(CC(C)C(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cc1	10.1016/j.bmcl.2010.04.013
		CHEMBL1086104	7315	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	379	6	3	5	3.4	Cc1c(CC(C)C(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cc1	10.1016/j.bmcl.2010.04.013
		11625092	6684	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	379	6	2	2	5.3	O=C(CCc1ccc(-c2ccccc2Cl)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		CHEMBL1083473	6684	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	379	6	2	2	5.3	O=C(CCc1ccc(-c2ccccc2Cl)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		156017170	177648	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	417	5	1	6	4.4	CCOc1cc(Cl)c(C(=O)Nc2nc3ccccc3s2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		CHEMBL4641449	177648	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	417	5	1	6	4.4	CCOc1cc(Cl)c(C(=O)Nc2nc3ccccc3s2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		57422810	177661	4	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	602	7	2	10	4.4	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1016/j.bmcl.2020.126953
		CHEMBL4641579	177661	4	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	602	7	2	10	4.4	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1016/j.bmcl.2020.126953
		46890275	6530	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	412	8	3	6	3.2	CCCC1CCC(C(=O)O)=C(NC(=O)C(C)Cc2ccn(-c3ccc(O)cn3)n2)C1	10.1016/j.bmcl.2010.04.013
		CHEMBL1082823	6530	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	412	8	3	6	3.2	CCCC1CCC(C(=O)O)=C(NC(=O)C(C)Cc2ccn(-c3ccc(O)cn3)n2)C1	10.1016/j.bmcl.2010.04.013
		24741310	89622	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	352	6	3	6	2.2	O=C(CCc1ccn(-c2ccc(O)cn2)n1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		CHEMBL237543	89622	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	352	6	3	6	2.2	O=C(CCc1ccn(-c2ccc(O)cn2)n1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		117629482	2823	140	None	-3	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at GPR109A (unknown origin) assessed as effect on beta-arrestin2 conformational changesAgonist activity at GPR109A (unknown origin) assessed as effect on beta-arrestin2 conformational changes	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/acs.jmedchem.8b00435
		1588	2823	140	None	-3	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at GPR109A (unknown origin) assessed as effect on beta-arrestin2 conformational changesAgonist activity at GPR109A (unknown origin) assessed as effect on beta-arrestin2 conformational changes	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/acs.jmedchem.8b00435
		1594	2823	140	None	-3	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at GPR109A (unknown origin) assessed as effect on beta-arrestin2 conformational changesAgonist activity at GPR109A (unknown origin) assessed as effect on beta-arrestin2 conformational changes	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/acs.jmedchem.8b00435
		2835	2823	140	None	-3	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at GPR109A (unknown origin) assessed as effect on beta-arrestin2 conformational changesAgonist activity at GPR109A (unknown origin) assessed as effect on beta-arrestin2 conformational changes	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/acs.jmedchem.8b00435
		938	2823	140	None	-3	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at GPR109A (unknown origin) assessed as effect on beta-arrestin2 conformational changesAgonist activity at GPR109A (unknown origin) assessed as effect on beta-arrestin2 conformational changes	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/acs.jmedchem.8b00435
		CHEMBL573	2823	140	None	-3	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at GPR109A (unknown origin) assessed as effect on beta-arrestin2 conformational changesAgonist activity at GPR109A (unknown origin) assessed as effect on beta-arrestin2 conformational changes	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/acs.jmedchem.8b00435
		DB00627	2823	140	None	-3	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at GPR109A (unknown origin) assessed as effect on beta-arrestin2 conformational changesAgonist activity at GPR109A (unknown origin) assessed as effect on beta-arrestin2 conformational changes	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/acs.jmedchem.8b00435
		156021885	178215	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	635	10	1	10	4.2	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1CCO[C@H](C)C1	10.1016/j.bmcl.2020.126953
		CHEMBL4649741	178215	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	635	10	1	10	4.2	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1CCO[C@H](C)C1	10.1016/j.bmcl.2020.126953
		1595	259	49	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmc.2015.02.018
		51576	259	49	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmc.2015.02.018
		CHEMBL278488	259	49	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmc.2015.02.018
		156018500	177924	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	629	7	1	10	4.5	CCOc1cc(Cl)c(-c2ncc(-c3nc4ccc(S(=O)(=O)C5CCN(C)CC5)cc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		CHEMBL4645314	177924	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	629	7	1	10	4.5	CCOc1cc(Cl)c(-c2ncc(-c3nc4ccc(S(=O)(=O)C5CCN(C)CC5)cc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		156019324	177974	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	530	7	1	8	4.9	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(OC4CCN(C)CC4)cc3s2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		CHEMBL4646005	177974	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	530	7	1	8	4.9	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(OC4CCN(C)CC4)cc3s2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		46890274	6906	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	384	6	3	6	2.4	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CC[C@@H](C)C1	10.1016/j.bmcl.2010.04.013
		CHEMBL1084332	6906	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	384	6	3	6	2.4	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CC[C@@H](C)C1	10.1016/j.bmcl.2010.04.013
		46890273	6849	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	358	6	3	6	1.7	O=C(CCc1ccn(-c2ccc(O)cn2)n1)N[C@@H]1CCCC[C@@H]1C(=O)O	10.1016/j.bmcl.2010.04.013
		CHEMBL1084060	6849	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	358	6	3	6	1.7	O=C(CCc1ccn(-c2ccc(O)cn2)n1)N[C@@H]1CCCC[C@@H]1C(=O)O	10.1016/j.bmcl.2010.04.013
		156011618	177398	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	544	7	1	8	3.6	CCOc1cc(Cl)c(-c2ccc(-c3nc4c(s3)CN(C(=O)COC)CC4)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		CHEMBL4638263	177398	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	544	7	1	8	3.6	CCOc1cc(Cl)c(-c2ccc(-c3nc4c(s3)CN(C(=O)COC)CC4)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		15986936	7101	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	356	6	3	6	1.9	O=C(CCc1cnn(-c2ccc(O)cn2)c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.013
		CHEMBL1085150	7101	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	356	6	3	6	1.9	O=C(CCc1cnn(-c2ccc(O)cn2)c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.013
		11197	1066	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
		154699458	1066	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
		CHEMBL4632411	1066	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
		46890276	6531	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	464	7	3	6	3.7	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CCC(c2cccc(F)c2)C1	10.1016/j.bmcl.2010.04.013
		CHEMBL1082824	6531	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	464	7	3	6	3.7	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CCC(c2cccc(F)c2)C1	10.1016/j.bmcl.2010.04.013
		46890240	7103	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	356	6	3	6	1.9	O=C(CCc1ccn(-c2ccc(O)cn2)n1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.013
		CHEMBL1085156	7103	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	356	6	3	6	1.9	O=C(CCc1ccn(-c2ccc(O)cn2)n1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.013
		46890237	7099	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	370	6	3	6	2.2	Cc1c(CCC(=O)NC2=C(C(=O)O)CCCC2)cnn1-c1ccc(O)cn1	10.1016/j.bmcl.2010.04.013
		CHEMBL1085148	7099	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	370	6	3	6	2.2	Cc1c(CCC(=O)NC2=C(C(=O)O)CCCC2)cnn1-c1ccc(O)cn1	10.1016/j.bmcl.2010.04.013
		46890199	7158	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	380	6	3	6	2.8	Cc1c(CC(C)C(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cn1	10.1016/j.bmcl.2010.04.013
		CHEMBL1085401	7158	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	380	6	3	6	2.8	Cc1c(CC(C)C(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cn1	10.1016/j.bmcl.2010.04.013
		156016073	177655	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@@H](C)C1	10.1016/j.bmcl.2020.126953
		CHEMBL4641503	177655	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@@H](C)C1	10.1016/j.bmcl.2020.126953
		46890165	7314	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	351	6	3	5	2.8	O=C(CCc1cnn(-c2ccc(O)cc2)c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		CHEMBL1086103	7314	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	351	6	3	5	2.8	O=C(CCc1cnn(-c2ccc(O)cc2)c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		15986929	7159	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	383	6	3	5	3.1	Cc1c(CC(C)C(=O)NC2=C(C(=O)O)CCCC2)cnn1-c1ccc(O)cc1	10.1016/j.bmcl.2010.04.013
		CHEMBL1085402	7159	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	383	6	3	5	3.1	Cc1c(CC(C)C(=O)NC2=C(C(=O)O)CCCC2)cnn1-c1ccc(O)cc1	10.1016/j.bmcl.2010.04.013
		156016110	177698	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	628	7	1	9	5.1	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccc(S(=O)(=O)C5CCN(C)CC5)cc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		CHEMBL4642043	177698	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	628	7	1	9	5.1	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccc(S(=O)(=O)C5CCN(C)CC5)cc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		46890272	6847	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	370	6	3	6	2.2	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.013
		CHEMBL1084059	6847	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	370	6	3	6	2.2	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.013
		46890164	7422	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	335	6	2	4	3.1	O=C(CCc1cnn(-c2ccccc2)c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		CHEMBL1086568	7422	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	335	6	2	4	3.1	O=C(CCc1cnn(-c2ccccc2)c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		11560300	88539	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	395	6	3	3	5.0	O=C(CCc1ccc(-c2ccc(O)cc2Cl)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		CHEMBL235256	88539	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	395	6	3	3	5.0	O=C(CCc1ccc(-c2ccc(O)cc2Cl)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		117629482	2823	140	None	-3	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmc.2015.02.018
		1588	2823	140	None	-3	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmc.2015.02.018
		1594	2823	140	None	-3	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmc.2015.02.018
		2835	2823	140	None	-3	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmc.2015.02.018
		938	2823	140	None	-3	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmc.2015.02.018
		CHEMBL573	2823	140	None	-3	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmc.2015.02.018
		DB00627	2823	140	None	-3	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmc.2015.02.018
		53322689	58060	1	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay	ChEMBL	224	1	2	5	0.7	CCc1cc(=O)oc2nc(S)[nH]c(=O)c12	10.1039/d2md00076h
		CHEMBL1672755	58060	1	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay	ChEMBL	224	1	2	5	0.7	CCc1cc(=O)oc2nc(S)[nH]c(=O)c12	10.1039/d2md00076h
		15605571	75235	2	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay	ChEMBL	236	3	2	4	0.5	CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1039/d2md00076h
		CHEMBL2036813	75235	2	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay	ChEMBL	236	3	2	4	0.5	CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1039/d2md00076h
		CHEMBL5270112	193620	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay	ChEMBL	252	3	2	4	1.9	CCCCc1cc(=O)oc2[nH]c(=S)[nH]c(=O)c12	10.1039/d2md00076h
		CHEMBL5275861	193872	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay	ChEMBL	286	4	2	4	2.1	O=c1cc(CCCCCl)c2c(=O)[nH]c(=S)[nH]c2o1	10.1039/d2md00076h
		CHEMBL5277000	193921	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay	ChEMBL	238	2	2	4	1.5	CCCc1cc(=O)oc2[nH]c(=S)[nH]c(=O)c12	10.1039/d2md00076h
		CHEMBL5281556	194116	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay	ChEMBL	210	0	2	4	0.8	Cc1cc(=O)oc2[nH]c(=S)[nH]c(=O)c12	10.1039/d2md00076h
		CHEMBL5284951	194273	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at human HCA2 expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay	ChEMBL	270	4	2	4	0.7	O=c1[nH]c(=O)c2c(CCCCCl)cc(=O)oc2[nH]1	10.1039/d2md00076h
		46890239	6934	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	370	6	3	6	2.2	CC(Cc1cnn(-c2ccc(O)cn2)c1)C(=O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.013
		CHEMBL1084448	6934	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	370	6	3	6	2.2	CC(Cc1cnn(-c2ccc(O)cn2)c1)C(=O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.013
		117629482	2823	140	None	-3	2	Human	6.2	pEC50	=	6.2	Binding	Activation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISAActivation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISA	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1074/jbc.m701866200
		1588	2823	140	None	-3	2	Human	6.2	pEC50	=	6.2	Binding	Activation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISAActivation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISA	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1074/jbc.m701866200
		1594	2823	140	None	-3	2	Human	6.2	pEC50	=	6.2	Binding	Activation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISAActivation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISA	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1074/jbc.m701866200
		2835	2823	140	None	-3	2	Human	6.2	pEC50	=	6.2	Binding	Activation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISAActivation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISA	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1074/jbc.m701866200
		938	2823	140	None	-3	2	Human	6.2	pEC50	=	6.2	Binding	Activation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISAActivation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISA	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1074/jbc.m701866200
		CHEMBL573	2823	140	None	-3	2	Human	6.2	pEC50	=	6.2	Binding	Activation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISAActivation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISA	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1074/jbc.m701866200
		DB00627	2823	140	None	-3	2	Human	6.2	pEC50	=	6.2	Binding	Activation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISAActivation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISA	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1074/jbc.m701866200
		156021336	178167	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	467	5	1	6	5.2	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		CHEMBL4649089	178167	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	467	5	1	6	5.2	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		46890301	7199	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	482	7	3	6	3.9	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1	10.1016/j.bmcl.2010.04.013
		CHEMBL1085616	7199	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	482	7	3	6	3.9	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1	10.1016/j.bmcl.2010.04.013
		156012428	177310	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@H](C)C1	10.1016/j.bmcl.2020.126953
		CHEMBL4636832	177310	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@H](C)C1	10.1016/j.bmcl.2020.126953
		46890300	7415	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	482	7	3	6	3.9	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CCC(c2cccc(F)c2F)C1	10.1016/j.bmcl.2010.04.013
		CHEMBL1086541	7415	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	482	7	3	6	3.9	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CCC(c2cccc(F)c2F)C1	10.1016/j.bmcl.2010.04.013
		46890198	7317	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	366	6	3	6	2.6	Cc1c(CCC(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cn1	10.1016/j.bmcl.2010.04.013
		CHEMBL1086108	7317	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	366	6	3	6	2.6	Cc1c(CCC(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cn1	10.1016/j.bmcl.2010.04.013
		46890238	7100	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	384	6	3	6	2.5	Cc1c(CC(C)C(=O)NC2=C(C(=O)O)CCCC2)cnn1-c1ccc(O)cn1	10.1016/j.bmcl.2010.04.013
		CHEMBL1085149	7100	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	384	6	3	6	2.5	Cc1c(CC(C)C(=O)NC2=C(C(=O)O)CCCC2)cnn1-c1ccc(O)cn1	10.1016/j.bmcl.2010.04.013
		9822	145638	133	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Activation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISAActivation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISA	ChEMBL	126	1	2	2	0.4	Cc1cc(C(=O)O)n[nH]1	10.1074/jbc.m701866200
		CHEMBL391574	145638	133	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Activation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISAActivation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISA	ChEMBL	126	1	2	2	0.4	Cc1cc(C(=O)O)n[nH]1	10.1074/jbc.m701866200
		156014693	177192	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	530	6	2	8	2.9	CCOc1cc(Cl)c(-c2ccc(-c3nc4c(s3)CN(C(=O)CO)CC4)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		CHEMBL4635089	177192	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at human GPR109A receptorAgonist activity at human GPR109A receptor	ChEMBL	530	6	2	8	2.9	CCOc1cc(Cl)c(-c2ccc(-c3nc4c(s3)CN(C(=O)CO)CC4)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		24741307	88735	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	365	6	3	5	3.2	Cc1c(CCC(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cc1	10.1016/j.bmcl.2010.04.013
		CHEMBL236163	88735	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	365	6	3	5	3.2	Cc1c(CCC(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cc1	10.1016/j.bmcl.2010.04.013
		46890197	7259	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	366	6	3	6	2.5	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		CHEMBL1085875	7259	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	366	6	3	6	2.5	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		46890302	7252	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	500	7	3	6	4.0	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CCC(c2cc(F)c(F)c(F)c2)C1	10.1016/j.bmcl.2010.04.013
		CHEMBL1085842	7252	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	500	7	3	6	4.0	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CCC(c2cc(F)c(F)c(F)c2)C1	10.1016/j.bmcl.2010.04.013
		46890163	7421	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	335	6	2	4	3.1	O=C(CCc1ccn(-c2ccccc2)n1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		CHEMBL1086567	7421	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumDisplacement of [3H]niacin from GRP109A receptor in presence of 4% human serum	ChEMBL	335	6	2	4	3.1	O=C(CCc1ccn(-c2ccccc2)n1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		135453098	88734	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	402	6	3	5	4.4	O=C(CCc1cnc(-c2ccc(O)cc2Cl)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		CHEMBL236162	88734	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	402	6	3	5	4.4	O=C(CCc1cnc(-c2ccc(O)cc2Cl)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		42625475	184209	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	414	5	3	5	4.3	O=C(CCc1noc2c1ccc1c(Cl)c(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
		CHEMBL483336	184209	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	414	5	3	5	4.3	O=C(CCc1noc2c1ccc1c(Cl)c(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
		42625476	184210	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	379	5	3	5	3.2	O=C(CCc1cnn2c1ccc1cc(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
		CHEMBL483337	184210	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	379	5	3	5	3.2	O=C(CCc1cnn2c1ccc1cc(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
		136000619	61445	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	369	6	4	8	1.0	N[C@@H](Cc1nc(-c2ccc(O)cn2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		CHEMBL1770352	61445	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	369	6	4	8	1.0	N[C@@H](Cc1nc(-c2ccc(O)cn2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		135453098	88734	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	402	6	3	5	4.4	O=C(CCc1cnc(-c2ccc(O)cc2Cl)s1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		CHEMBL236162	88734	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	402	6	3	5	4.4	O=C(CCc1cnc(-c2ccc(O)cc2Cl)s1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		46890272	6847	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	370	6	3	6	2.2	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.013
		CHEMBL1084059	6847	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	370	6	3	6	2.2	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.013
		135800177	145951	7	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	353	6	3	6	2.7	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		CHEMBL391813	145951	7	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	353	6	3	6	2.7	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		135800177	145951	7	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	353	6	3	6	2.7	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		CHEMBL391813	145951	7	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	353	6	3	6	2.7	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		135627640	61397	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	417	6	4	6	3.4	NC(Cc1cnc(-c2ccc(O)cc2Cl)s1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		CHEMBL1770172	61397	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	417	6	4	6	3.4	NC(Cc1cnc(-c2ccc(O)cc2Cl)s1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		136088959	61447	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	383	6	4	8	1.6	CC(c1nc(-c2ccc(O)cn2)no1)[C@H](N)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		CHEMBL1770354	61447	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	383	6	4	8	1.6	CC(c1nc(-c2ccc(O)cn2)no1)[C@H](N)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		44580008	186948	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	414	7	1	5	4.6	Cc1c(C(=O)NCCOc2ccccc2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
		CHEMBL490216	186948	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	414	7	1	5	4.6	Cc1c(C(=O)NCCOc2ccccc2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
		156013291	177505	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	455	9	3	9	1.8	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1cn(CCN2CCOCC2)cc1C(=O)O	10.1016/j.bmcl.2020.127105
		CHEMBL4639589	177505	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	455	9	3	9	1.8	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1cn(CCN2CCOCC2)cc1C(=O)O	10.1016/j.bmcl.2020.127105
		122181143	121831	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	367	6	3	4	4.4	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)Nc1sccc1C(=O)O	10.1016/j.bmc.2015.02.018
		CHEMBL3589837	121831	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	367	6	3	4	4.4	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)Nc1sccc1C(=O)O	10.1016/j.bmc.2015.02.018
		122181142	121830	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	365	6	3	3	4.0	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2015.02.018
		CHEMBL3589836	121830	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	365	6	3	3	4.0	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2015.02.018
		136000718	61402	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	368	6	4	7	2.2	N[C@H](CC(=O)Nc1ccccc1C(=O)O)c1nc(-c2ccc(O)cc2)no1	10.1016/j.bmcl.2010.11.116
		CHEMBL1770177	61402	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	368	6	4	7	2.2	N[C@H](CC(=O)Nc1ccccc1C(=O)O)c1nc(-c2ccc(O)cc2)no1	10.1016/j.bmcl.2010.11.116
		11617852	184535	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	381	5	3	6	3.5	O=C(CCc1cn2c(n1)sc1cc(O)ccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
		CHEMBL484783	184535	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	381	5	3	6	3.5	O=C(CCc1cn2c(n1)sc1cc(O)ccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
		46890297	7214	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	433	6	3	3	5.0	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccccc2F)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1085653	7214	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	433	6	3	3	5.0	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccccc2F)CC1	10.1016/j.bmcl.2010.04.001
		136000580	61449	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	387	6	4	8	1.0	C[C@@H]1CCC(C(=O)O)=C(NC(=O)[C@@H](N)Cc2nc(-c3ccc(O)cn3)no2)C1	10.1016/j.bmcl.2010.11.116
		CHEMBL1770356	61449	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	387	6	4	8	1.0	C[C@@H]1CCC(C(=O)O)=C(NC(=O)[C@@H](N)Cc2nc(-c3ccc(O)cn3)no2)C1	10.1016/j.bmcl.2010.11.116
		15981408	94346	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	405	3	2	5	3.5	C[C@H]1CN(c2cnc3ccccc3n2)C[C@@H](C)N1C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2007.10.055
		CHEMBL250690	94346	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	405	3	2	5	3.5	C[C@H]1CN(c2cnc3ccccc3n2)C[C@@H](C)N1C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2007.10.055
		156011372	177352	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	415	10	3	9	1.9	COCCCn1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		CHEMBL4637548	177352	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	415	10	3	9	1.9	COCCCn1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		49862074	14974	0	None	-	0	Mouse	6.0	pIC50	=	6.0	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	208	3	2	2	1.9	CCC(C)C1Cc2[nH]nc(C(=O)O)c2C1	10.1016/j.bmcl.2010.06.041
		CHEMBL1208921	14974	0	None	-	0	Mouse	6.0	pIC50	=	6.0	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	208	3	2	2	1.9	CCC(C)C1Cc2[nH]nc(C(=O)O)c2C1	10.1016/j.bmcl.2010.06.041
		135899129	16138	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	315	6	1	5	2.3	O=c1[nH]c(OCCCOc2ccc(F)cc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1223961	16138	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	315	6	1	5	2.3	O=c1[nH]c(OCCCOc2ccc(F)cc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		156012920	177449	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	433	8	3	8	3.0	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1cn(Cc2ccncc2)cc1C(=O)O	10.1016/j.bmcl.2020.127105
		CHEMBL4638809	177449	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	433	8	3	8	3.0	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1cn(Cc2ccncc2)cc1C(=O)O	10.1016/j.bmcl.2020.127105
		44591603	191702	0	None	-	0	Mouse	5.0	pIC50	=	5.0	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	266	2	2	4	1.8	Cc1cccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		CHEMBL519689	191702	0	None	-	0	Mouse	5.0	pIC50	=	5.0	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	266	2	2	4	1.8	Cc1cccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		136000669	61404	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	382	7	4	7	1.9	CN[C@@H](Cc1nc(-c2ccc(O)cc2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		CHEMBL1770179	61404	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	382	7	4	7	1.9	CN[C@@H](Cc1nc(-c2ccc(O)cc2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		46890276	6531	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	464	7	3	6	3.7	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CCC(c2cccc(F)c2)C1	10.1016/j.bmcl.2010.04.013
		CHEMBL1082824	6531	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	464	7	3	6	3.7	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CCC(c2cccc(F)c2)C1	10.1016/j.bmcl.2010.04.013
		136086828	7193	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	502	7	3	7	3.9	C[C@H]1CC(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)=C(C(=O)O)C[C@H]1c1cc(F)cc(F)c1F	10.1016/j.bmcl.2010.04.001
		CHEMBL1085589	7193	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	502	7	3	7	3.9	C[C@H]1CC(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)=C(C(=O)O)C[C@H]1c1cc(F)cc(F)c1F	10.1016/j.bmcl.2010.04.001
		53238781	1027	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	389	6	3	7	1.4	C[C@@H]1CCC(=C(C1)NC(=O)[C@H](Cc1onc(n1)c1ccc(cn1)F)N)C(=O)O	10.1016/j.bmcl.2010.11.116
		5789	1027	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	389	6	3	7	1.4	C[C@@H]1CCC(=C(C1)NC(=O)[C@H](Cc1onc(n1)c1ccc(cn1)F)N)C(=O)O	10.1016/j.bmcl.2010.11.116
		CHEMBL1770358	1027	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	389	6	3	7	1.4	C[C@@H]1CCC(=C(C1)NC(=O)[C@H](Cc1onc(n1)c1ccc(cn1)F)N)C(=O)O	10.1016/j.bmcl.2010.11.116
		11566404	145671	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	346	6	2	3	4.0	O=C(CCc1ccc(-c2ccccn2)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		CHEMBL391603	145671	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	346	6	2	3	4.0	O=C(CCc1ccc(-c2ccccn2)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		46890400	7286	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	419	6	3	5	3.6	Cn1cc(C2CCC(NC(=O)CCc3ccc4cc(O)ccc4c3)=C(C(=O)O)C2)cn1	10.1016/j.bmcl.2010.04.001
		CHEMBL1086030	7286	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	419	6	3	5	3.6	Cn1cc(C2CCC(NC(=O)CCc3ccc4cc(O)ccc4c3)=C(C(=O)O)C2)cn1	10.1016/j.bmcl.2010.04.001
		54585613	61399	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	392	5	4	6	1.9	NC(Cc1cc2n(n1)-c1ccc(O)cc1CC2)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		CHEMBL1770174	61399	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	392	5	4	6	1.9	NC(Cc1cc2n(n1)-c1ccc(O)cc1CC2)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		16048839	155016	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	382	3	2	5	3.3	O=C(O)c1ccccc1NC(=O)N1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmcl.2007.10.055
		CHEMBL401469	155016	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	382	3	2	5	3.3	O=C(O)c1ccccc1NC(=O)N1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmcl.2007.10.055
		4268702	169652	8	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	327	5	2	3	3.7	CC(C)(C)c1ccc(OCC(=O)Nc2ccccc2C(=O)O)cc1	10.1016/j.bmcl.2008.08.030
		CHEMBL443733	169652	8	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	327	5	2	3	3.7	CC(C)(C)c1ccc(OCC(=O)Nc2ccccc2C(=O)O)cc1	10.1016/j.bmcl.2008.08.030
		11159621	2548	46	None	-	1	Mouse	5.9	pIC50	=	5.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2009.03.014
		5784	2548	46	None	-	1	Mouse	5.9	pIC50	=	5.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2009.03.014
		CHEMBL456145	2548	46	None	-	1	Mouse	5.9	pIC50	=	5.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2009.03.014
		DB05939	2548	46	None	-	1	Mouse	5.9	pIC50	=	5.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2009.03.014
		11159621	2548	46	None	-	1	Mouse	5.9	pIC50	=	5.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2010.06.041
		5784	2548	46	None	-	1	Mouse	5.9	pIC50	=	5.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2010.06.041
		CHEMBL456145	2548	46	None	-	1	Mouse	5.9	pIC50	=	5.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2010.06.041
		DB05939	2548	46	None	-	1	Mouse	5.9	pIC50	=	5.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2010.06.041
		135899108	16211	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	315	5	1	4	2.7	O=c1[nH]c(COCCc2ccc(Cl)cc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1224220	16211	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	315	5	1	4	2.7	O=c1[nH]c(COCCc2ccc(Cl)cc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		122181139	121827	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	375	6	3	3	4.6	Cc1cc(O)ccc1-c1ccc(CCC(=O)Nc2ccccc2C(=O)O)cc1	10.1016/j.bmc.2015.02.018
		CHEMBL3589833	121827	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	375	6	3	3	4.6	Cc1cc(O)ccc1-c1ccc(CCC(=O)Nc2ccccc2C(=O)O)cc1	10.1016/j.bmc.2015.02.018
		11494579	1058	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	377	5	3	5	2.9	O=C(Nc1ccccc1C(=O)O)CCc1cnn2c1CCc1c2ccc(c1)O	10.1021/jm900151e
		5791	1058	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	377	5	3	5	2.9	O=C(Nc1ccccc1C(=O)O)CCc1cnn2c1CCc1c2ccc(c1)O	10.1021/jm900151e
		CHEMBL482768	1058	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	377	5	3	5	2.9	O=C(Nc1ccccc1C(=O)O)CCc1cnn2c1CCc1c2ccc(c1)O	10.1021/jm900151e
		135416383	184909	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	368	5	3	5	2.7	O=C(CCc1noc2c1CCc1cc(O)ccc1-2)NC1=C(C(=O)O)CCC1	10.1021/jm900151e
		CHEMBL485326	184909	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	368	5	3	5	2.7	O=C(CCc1noc2c1CCc1cc(O)ccc1-2)NC1=C(C(=O)O)CCC1	10.1021/jm900151e
		54580748	61398	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	377	5	3	5	2.9	O=C(CCc1cc2n(n1)-c1ccc(O)cc1CC2)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		CHEMBL1770173	61398	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	377	5	3	5	2.9	O=C(CCc1cc2n(n1)-c1ccc(O)cc1CC2)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		137635325	156149	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	313	4	3	3	2.6	O=C(CCC#Cc1ccc(O)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4063682	156149	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	313	4	3	3	2.6	O=C(CCC#Cc1ccc(O)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		135922722	184191	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	391	5	3	5	3.2	Cn1nc(CCC(=O)Nc2ccccc2C(=O)O)c2c1-c1ccc(O)cc1CC2	10.1021/jm900151e
		CHEMBL483160	184191	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	391	5	3	5	3.2	Cn1nc(CCC(=O)Nc2ccccc2C(=O)O)c2c1-c1ccc(O)cc1CC2	10.1021/jm900151e
		117629482	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.030
		1588	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.030
		1594	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.030
		2835	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.030
		938	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.030
		CHEMBL573	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.030
		DB00627	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.030
		135899320	16133	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	297	6	1	5	2.2	O=c1[nH]c(OCCCOc2ccccc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1223957	16133	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	297	6	1	5	2.2	O=c1[nH]c(OCCCOc2ccccc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		44579762	187159	1	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	428	7	1	5	5.0	Cc1c(C(=O)NC(C)COc2ccccc2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
		CHEMBL492020	187159	1	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	428	7	1	5	5.0	Cc1c(C(=O)NC(C)COc2ccccc2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
		49862074	14974	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	208	3	2	2	1.9	CCC(C)C1Cc2[nH]nc(C(=O)O)c2C1	10.1016/j.bmcl.2010.06.041
		CHEMBL1208921	14974	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	208	3	2	2	1.9	CCC(C)C1Cc2[nH]nc(C(=O)O)c2C1	10.1016/j.bmcl.2010.06.041
		11183317	191470	0	None	-	0	Mouse	5.9	pIC50	=	5.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	204	2	2	4	0.7	CCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL519338	191470	0	None	-	0	Mouse	5.9	pIC50	=	5.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	204	2	2	4	0.7	CCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		136127010	16086	11	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	215	0	1	3	1.3	O=c1[nH]c(C(F)(F)F)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1223819	16086	11	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	215	0	1	3	1.3	O=c1[nH]c(C(F)(F)F)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		46890273	6849	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	358	6	3	6	1.7	O=C(CCc1ccn(-c2ccc(O)cn2)n1)N[C@@H]1CCCC[C@@H]1C(=O)O	10.1016/j.bmcl.2010.04.013
		CHEMBL1084060	6849	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	358	6	3	6	1.7	O=C(CCc1ccn(-c2ccc(O)cn2)n1)N[C@@H]1CCCC[C@@H]1C(=O)O	10.1016/j.bmcl.2010.04.013
		137655320	158538	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	313	4	3	3	2.6	O=C(CCC#Cc1cccc(O)c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4091501	158538	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	313	4	3	3	2.6	O=C(CCC#Cc1cccc(O)c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		46890274	6906	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	384	6	3	6	2.4	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CC[C@@H](C)C1	10.1016/j.bmcl.2010.04.013
		CHEMBL1084332	6906	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	384	6	3	6	2.4	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CC[C@@H](C)C1	10.1016/j.bmcl.2010.04.013
		46890399	7285	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	419	6	3	5	3.6	Cn1nccc1C1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
		CHEMBL1086029	7285	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	419	6	3	5	3.6	Cn1nccc1C1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
		117629482	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.013
		1588	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.013
		1594	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.013
		2835	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.013
		938	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.013
		CHEMBL573	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.013
		DB00627	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.013
		135401973	1022	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	393	3	3	6	2.4	Oc1ccc2c(c1)ncc(n2)N1CCN(CC1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2007.10.055
		5792	1022	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	393	3	3	6	2.4	Oc1ccc2c(c1)ncc(n2)N1CCN(CC1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2007.10.055
		CHEMBL398496	1022	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	393	3	3	6	2.4	Oc1ccc2c(c1)ncc(n2)N1CCN(CC1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2007.10.055
		117629482	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.10.055
		117629482	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
		1588	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.10.055
		1588	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
		1594	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.10.055
		1594	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
		2835	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.10.055
		2835	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
		938	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.10.055
		938	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
		CHEMBL573	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.10.055
		CHEMBL573	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
		DB00627	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.10.055
		DB00627	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
		11594881	88638	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	319	5	2	2	4.1	O=C(CCc1ccc2ccccc2c1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		CHEMBL235740	88638	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	319	5	2	2	4.1	O=C(CCc1ccc2ccccc2c1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		117629482	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
		1588	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
		1594	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
		2835	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
		938	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
		CHEMBL573	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
		DB00627	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm900151e
		117629482	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.001
		1588	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.001
		1594	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.001
		2835	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.001
		938	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.001
		CHEMBL573	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.001
		DB00627	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.04.001
		117629482	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
		1588	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
		1594	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
		2835	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
		938	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
		CHEMBL573	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
		DB00627	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
		117629482	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
		1588	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
		1594	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
		2835	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
		938	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
		CHEMBL573	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
		DB00627	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.06.054
		117629482	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from mouse GPR109ADisplacement of [3H]niacin from mouse GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
		1588	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from mouse GPR109ADisplacement of [3H]niacin from mouse GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
		1594	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from mouse GPR109ADisplacement of [3H]niacin from mouse GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
		2835	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from mouse GPR109ADisplacement of [3H]niacin from mouse GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
		938	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from mouse GPR109ADisplacement of [3H]niacin from mouse GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
		CHEMBL573	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from mouse GPR109ADisplacement of [3H]niacin from mouse GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
		DB00627	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]niacin from mouse GPR109ADisplacement of [3H]niacin from mouse GPR109A	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm700942d
		11594881	88638	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	319	5	2	2	4.1	O=C(CCc1ccc2ccccc2c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2008.08.030
		CHEMBL235740	88638	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	319	5	2	2	4.1	O=C(CCc1ccc2ccccc2c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2008.08.030
		117629482	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.03.014
		1588	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.03.014
		1594	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.03.014
		2835	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.03.014
		938	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.03.014
		CHEMBL573	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.03.014
		DB00627	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.03.014
		12002517	191882	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	270	2	2	4	1.6	Fc1cccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		CHEMBL519966	191882	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	270	2	2	4	1.6	Fc1cccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		12002525	192343	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1cccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1F	10.1016/j.bmcl.2009.03.014
		CHEMBL520676	192343	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1cccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1F	10.1016/j.bmcl.2009.03.014
		117629482	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.06.041
		1588	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.06.041
		1594	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.06.041
		2835	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.06.041
		938	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.06.041
		CHEMBL573	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.06.041
		DB00627	2823	140	None	-3	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.06.041
		117629482	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.03.014
		1588	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.03.014
		1594	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.03.014
		2835	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.03.014
		938	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.03.014
		CHEMBL573	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.03.014
		DB00627	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2009.03.014
		12002522	188456	0	None	-	0	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	286	2	2	4	2.1	Clc1cccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		CHEMBL502716	188456	0	None	-	0	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	286	2	2	4	2.1	Clc1cccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		117629482	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.06.041
		1588	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.06.041
		1594	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.06.041
		2835	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.06.041
		938	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.06.041
		CHEMBL573	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.06.041
		DB00627	2823	140	None	-	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2010.06.041
		135899171	16170	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Displacement of radioligand from rat GPR109ADisplacement of radioligand from rat GPR109A	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1224070	16170	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Displacement of radioligand from rat GPR109ADisplacement of radioligand from rat GPR109A	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		122181102	121810	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	379	6	2	2	5.3	O=C(CCc1ccc(-c2cccc(Cl)c2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		CHEMBL3589784	121810	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	379	6	2	2	5.3	O=C(CCc1ccc(-c2cccc(Cl)c2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		46890302	7252	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	500	7	3	6	4.0	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CCC(c2cc(F)c(F)c(F)c2)C1	10.1016/j.bmcl.2010.04.013
		CHEMBL1085842	7252	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	500	7	3	6	4.0	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CCC(c2cc(F)c(F)c(F)c2)C1	10.1016/j.bmcl.2010.04.013
		46890198	7317	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	366	6	3	6	2.6	Cc1c(CCC(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cn1	10.1016/j.bmcl.2010.04.013
		CHEMBL1086108	7317	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	366	6	3	6	2.6	Cc1c(CCC(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cn1	10.1016/j.bmcl.2010.04.013
		46890578	6391	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	505	7	3	7	3.0	NC(Cc1nc(-c2ccc(F)cn2)no1)C(=O)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2F)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1082294	6391	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	505	7	3	7	3.0	NC(Cc1nc(-c2ccc(F)cn2)no1)C(=O)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2F)CC1	10.1016/j.bmcl.2010.04.001
		135899171	16170	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1224070	16170	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		52941721	54965	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	283	1	0	7	4.2	Fc1ncccc1C1CCC2=C(C1)C(=C1N=NN=N1)N=N2	10.1016/j.bmcl.2009.06.054
		CHEMBL1204125	54965	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	283	1	0	7	4.2	Fc1ncccc1C1CCC2=C(C1)C(=C1N=NN=N1)N=N2	10.1016/j.bmcl.2009.06.054
		CHEMBL1615577	54965	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	283	1	0	7	4.2	Fc1ncccc1C1CCC2=C(C1)C(=C1N=NN=N1)N=N2	10.1016/j.bmcl.2009.06.054
		12002717	196742	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	302	2	2	4	2.1	Fc1ccc(F)c(C2CCc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.06.054
		CHEMBL565163	196742	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	302	2	2	4	2.1	Fc1ccc(F)c(C2CCc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.06.054
		52941721	54965	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	283	1	0	7	4.2	Fc1ncccc1C1CCC2=C(C1)C(=C1N=NN=N1)N=N2	10.1016/j.bmcl.2009.06.054
		CHEMBL1204125	54965	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	283	1	0	7	4.2	Fc1ncccc1C1CCC2=C(C1)C(=C1N=NN=N1)N=N2	10.1016/j.bmcl.2009.06.054
		CHEMBL1615577	54965	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	283	1	0	7	4.2	Fc1ncccc1C1CCC2=C(C1)C(=C1N=NN=N1)N=N2	10.1016/j.bmcl.2009.06.054
		54587625	61396	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	376	6	4	4	3.3	N[C@@H](Cc1ccc(-c2ccc(O)cc2)cc1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		CHEMBL1770171	61396	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	376	6	4	4	3.3	N[C@@H](Cc1ccc(-c2ccc(O)cc2)cc1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		117629482	2823	140	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.039
		1588	2823	140	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.039
		1594	2823	140	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.039
		2835	2823	140	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.039
		938	2823	140	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.039
		CHEMBL573	2823	140	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.039
		DB00627	2823	140	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2008.08.039
		11852982	14975	0	None	-	0	Mouse	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	228	2	2	2	2.0	O=C(O)c1n[nH]c2c1CC(c1ccccc1)C2	10.1016/j.bmcl.2010.06.041
		CHEMBL1208922	14975	0	None	-	0	Mouse	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	228	2	2	2	2.0	O=C(O)c1n[nH]c2c1CC(c1ccccc1)C2	10.1016/j.bmcl.2010.06.041
		11159621	2548	46	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2009.03.014
		5784	2548	46	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2009.03.014
		CHEMBL456145	2548	46	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2009.03.014
		DB05939	2548	46	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2009.03.014
		11159621	2548	46	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2010.06.041
		5784	2548	46	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2010.06.041
		CHEMBL456145	2548	46	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2010.06.041
		DB05939	2548	46	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1016/j.bmcl.2010.06.041
		135899199	16227	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	311	6	1	5	2.1	COc1cccc(CCOCc2nc3ncccc3c(=O)[nH]2)c1	10.1016/j.bmcl.2010.07.108
		CHEMBL1224293	16227	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	311	6	1	5	2.1	COc1cccc(CCOCc2nc3ncccc3c(=O)[nH]2)c1	10.1016/j.bmcl.2010.07.108
		136088957	61403	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	368	6	4	7	2.2	N[C@@H](CC(=O)Nc1ccccc1C(=O)O)c1nc(-c2ccc(O)cc2)no1	10.1016/j.bmcl.2010.11.116
		CHEMBL1770178	61403	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	368	6	4	7	2.2	N[C@@H](CC(=O)Nc1ccccc1C(=O)O)c1nc(-c2ccc(O)cc2)no1	10.1016/j.bmcl.2010.11.116
		24811550	6680	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	434	6	3	4	4.4	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccc(F)nc2)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1083450	6680	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	434	6	3	4	4.4	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccc(F)nc2)CC1	10.1016/j.bmcl.2010.04.001
		11624691	7227	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	361	6	3	3	4.3	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		CHEMBL1085711	7227	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	361	6	3	3	4.3	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		137640776	157004	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	313	3	2	2	2.8	O=C(/C=C/C#Cc1ccccc1F)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4073322	157004	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	313	3	2	2	2.8	O=C(/C=C/C#Cc1ccccc1F)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		117629482	2823	140	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Agonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysisAgonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
		1588	2823	140	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Agonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysisAgonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
		1594	2823	140	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Agonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysisAgonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
		2835	2823	140	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Agonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysisAgonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
		938	2823	140	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Agonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysisAgonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
		CHEMBL573	2823	140	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Agonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysisAgonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
		DB00627	2823	140	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Agonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysisAgonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
		44445341	154248	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	376	4	2	5	3.2	O=C(O)c1ccccc1NC(=O)C1CCN(c2cnc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
		CHEMBL398625	154248	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	376	4	2	5	3.2	O=C(O)c1ccccc1NC(=O)C1CCN(c2cnc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
		156022048	178201	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	383	7	3	8	2.2	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1cn(C2CC2)cc1C(=O)O	10.1016/j.bmcl.2020.127105
		CHEMBL4649587	178201	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	383	7	3	8	2.2	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1cn(C2CC2)cc1C(=O)O	10.1016/j.bmcl.2020.127105
		12002619	184180	0	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c(F)c1	10.1016/j.bmcl.2009.03.014
		CHEMBL483141	184180	0	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c(F)c1	10.1016/j.bmcl.2009.03.014
		12003695	14979	0	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	232	2	2	4	0.7	Cn1cc(C2Cc3[nH]nc(C(=O)O)c3C2)cn1	10.1016/j.bmcl.2010.06.041
		CHEMBL1208926	14979	0	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	232	2	2	4	0.7	Cn1cc(C2Cc3[nH]nc(C(=O)O)c3C2)cn1	10.1016/j.bmcl.2010.06.041
		44591603	191702	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	266	2	2	4	1.8	Cc1cccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		CHEMBL519689	191702	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	266	2	2	4	1.8	Cc1cccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		135502978	191989	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	377	5	4	4	3.2	O=C(CCc1[nH]nc2c1CCc1cc(O)ccc1-2)Nc1ccccc1C(=O)O	10.1021/jm900151e
		CHEMBL520136	191989	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	377	5	4	4	3.2	O=C(CCc1[nH]nc2c1CCc1cc(O)ccc1-2)Nc1ccccc1C(=O)O	10.1021/jm900151e
		25101223	1152	7	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	428	7	1	5	5.0	C[C@@H](NC(=O)c1cnc2n(c1C)ncc2c1ccc(cc1)C(C)C)COc1ccccc1	10.1016/j.bmcl.2008.08.039
		5795	1152	7	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	428	7	1	5	5.0	C[C@@H](NC(=O)c1cnc2n(c1C)ncc2c1ccc(cc1)C(C)C)COc1ccccc1	10.1016/j.bmcl.2008.08.039
		CHEMBL490599	1152	7	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	428	7	1	5	5.0	C[C@@H](NC(=O)c1cnc2n(c1C)ncc2c1ccc(cc1)C(C)C)COc1ccccc1	10.1016/j.bmcl.2008.08.039
		49862073	14973	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	194	2	2	2	1.5	CC(C)C1Cc2[nH]nc(C(=O)O)c2C1	10.1016/j.bmcl.2010.06.041
		CHEMBL1208920	14973	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	194	2	2	2	1.5	CC(C)C1Cc2[nH]nc(C(=O)O)c2C1	10.1016/j.bmcl.2010.06.041
		12002520	184153	0	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	270	2	2	4	1.6	Fc1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)cc1	10.1016/j.bmcl.2009.03.014
		CHEMBL482943	184153	0	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	270	2	2	4	1.6	Fc1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)cc1	10.1016/j.bmcl.2009.03.014
		135899152	16226	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	311	6	1	5	2.1	COc1ccccc1CCOCc1nc2ncccc2c(=O)[nH]1	10.1016/j.bmcl.2010.07.108
		CHEMBL1224292	16226	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	311	6	1	5	2.1	COc1ccccc1CCOCc1nc2ncccc2c(=O)[nH]1	10.1016/j.bmcl.2010.07.108
		11646179	184813	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	359	5	3	3	4.0	O=C(CCc1ccc2c(ccc3[nH]ncc32)c1)Nc1ccccc1C(=O)O	10.1021/jm900151e
		CHEMBL485185	184813	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	359	5	3	3	4.0	O=C(CCc1ccc2c(ccc3[nH]ncc32)c1)Nc1ccccc1C(=O)O	10.1021/jm900151e
		46890328	6681	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	484	6	3	4	5.3	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccc(C(F)(F)F)nc2)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1083451	6681	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	484	6	3	4	5.3	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccc(C(F)(F)F)nc2)CC1	10.1016/j.bmcl.2010.04.001
		156021045	178131	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	399	9	3	8	2.7	CCCCn1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		CHEMBL4648435	178131	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	399	9	3	8	2.7	CCCCn1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		156017210	177730	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	414	8	4	3	5.1	CCCCc1cc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)[nH]1	10.1016/j.bmcl.2020.127105
		CHEMBL4642367	177730	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	414	8	4	3	5.1	CCCCc1cc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)[nH]1	10.1016/j.bmcl.2020.127105
		11625092	6684	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	379	6	2	2	5.3	O=C(CCc1ccc(-c2ccccc2Cl)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		CHEMBL1083473	6684	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	379	6	2	2	5.3	O=C(CCc1ccc(-c2ccccc2Cl)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		46890539	7040	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	472	7	2	6	3.9	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1084841	7040	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	472	7	2	6	3.9	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
		136375455	177554	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	385	7	3	8	2.5	CC(C)n1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		CHEMBL4640349	177554	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	385	7	3	8	2.5	CC(C)n1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		12002523	171949	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	286	2	2	4	2.1	Clc1ccccc1C1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL447050	171949	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	286	2	2	4	2.1	Clc1ccccc1C1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		12003601	14980	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	218	2	2	4	0.6	O=C(O)c1n[nH]c2c1CC(n1cccn1)C2	10.1016/j.bmcl.2010.06.041
		CHEMBL1208987	14980	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	218	2	2	4	0.6	O=C(O)c1n[nH]c2c1CC(n1cccn1)C2	10.1016/j.bmcl.2010.06.041
		135899263	16112	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	307	7	1	3	3.7	O=c1[nH]c(CCCCCCc2ccccc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1223875	16112	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	307	7	1	3	3.7	O=c1[nH]c(CCCCCCc2ccccc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		156021045	178131	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Agonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysisAgonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysis	ChEMBL	399	9	3	8	2.7	CCCCn1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		CHEMBL4648435	178131	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Agonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysisAgonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysis	ChEMBL	399	9	3	8	2.7	CCCCn1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		24741312	89399	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	358	6	3	7	2.3	O=C(CCc1cnc(-n2cc(O)cn2)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		CHEMBL237036	89399	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	358	6	3	7	2.3	O=C(CCc1cnc(-n2cc(O)cn2)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		136088961	61450	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	387	6	4	8	1.0	CC1CCC(NC(=O)[C@@H](N)Cc2nc(-c3ccc(O)cn3)no2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.11.116
		CHEMBL1770357	61450	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	387	6	4	8	1.0	CC1CCC(NC(=O)[C@@H](N)Cc2nc(-c3ccc(O)cn3)no2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.11.116
		12003490	14976	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	282	2	2	2	2.4	O=C(O)c1n[nH]c2c1CC(c1cc(F)cc(F)c1F)C2	10.1016/j.bmcl.2010.06.041
		CHEMBL1208923	14976	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	282	2	2	2	2.4	O=C(O)c1n[nH]c2c1CC(c1cc(F)cc(F)c1F)C2	10.1016/j.bmcl.2010.06.041
		12003791	194829	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
		CHEMBL1237147	194829	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
		CHEMBL539398	194829	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
		11852982	14975	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	228	2	2	2	2.0	O=C(O)c1n[nH]c2c1CC(c1ccccc1)C2	10.1016/j.bmcl.2010.06.041
		CHEMBL1208922	14975	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	228	2	2	2	2.0	O=C(O)c1n[nH]c2c1CC(c1ccccc1)C2	10.1016/j.bmcl.2010.06.041
		16048997	94657	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	394	3	2	4	3.4	O=C(O)c1ccccc1NC(=O)N1CCN(c2c(Cl)cncc2Cl)CC1	10.1016/j.bmcl.2007.10.055
		CHEMBL252507	94657	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	394	3	2	4	3.4	O=C(O)c1ccccc1NC(=O)N1CCN(c2c(Cl)cncc2Cl)CC1	10.1016/j.bmcl.2007.10.055
		122181105	121817	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	375	6	3	3	4.6	Cc1cc(-c2ccc(CCC(=O)Nc3ccccc3C(=O)O)cc2)ccc1O	10.1016/j.bmc.2015.02.018
		CHEMBL3589791	121817	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	375	6	3	3	4.6	Cc1cc(-c2ccc(CCC(=O)Nc3ccccc3C(=O)O)cc2)ccc1O	10.1016/j.bmc.2015.02.018
		11493732	193100	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	335	5	3	3	3.8	O=C(CCc1ccc2cc(O)ccc2c1)Nc1ccccc1C(=O)O	10.1021/jm900151e
		CHEMBL522649	193100	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	335	5	3	3	3.8	O=C(CCc1ccc2cc(O)ccc2c1)Nc1ccccc1C(=O)O	10.1021/jm900151e
		54584718	61451	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	374	6	2	6	2.5	C[C@@H]1CCC(C(=O)O)=C(NC(=O)CCc2nc(-c3ccc(F)cn3)no2)C1	10.1016/j.bmcl.2010.11.116
		CHEMBL1770359	61451	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	374	6	2	6	2.5	C[C@@H]1CCC(C(=O)O)=C(NC(=O)CCc2nc(-c3ccc(F)cn3)no2)C1	10.1016/j.bmcl.2010.11.116
		122181142	121830	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	365	6	3	3	4.0	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL3589836	121830	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	365	6	3	3	4.0	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		11736428	189063	0	None	-	0	Mouse	6.7	pIC50	=	6.7	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	232	4	2	4	1.5	CCCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL509541	189063	0	None	-	0	Mouse	6.7	pIC50	=	6.7	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	232	4	2	4	1.5	CCCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		16048992	94682	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	403	4	2	5	3.2	O=C(O)c1ccccc1NC(=O)N1CCN(c2nccc(-c3ccccc3)n2)CC1	10.1016/j.bmcl.2007.10.055
		CHEMBL252707	94682	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	403	4	2	5	3.2	O=C(O)c1ccccc1NC(=O)N1CCN(c2nccc(-c3ccccc3)n2)CC1	10.1016/j.bmcl.2007.10.055
		135922719	184287	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	377	5	3	5	3.0	Cn1nc(CCC(=O)Nc2ccccc2C(=O)O)c2c1-c1ccc(O)cc1C2	10.1021/jm900151e
		CHEMBL483996	184287	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	377	5	3	5	3.0	Cn1nc(CCC(=O)Nc2ccccc2C(=O)O)c2c1-c1ccc(O)cc1C2	10.1021/jm900151e
		12003695	14979	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	232	2	2	4	0.7	Cn1cc(C2Cc3[nH]nc(C(=O)O)c3C2)cn1	10.1016/j.bmcl.2010.06.041
		CHEMBL1208926	14979	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	232	2	2	4	0.7	Cn1cc(C2Cc3[nH]nc(C(=O)O)c3C2)cn1	10.1016/j.bmcl.2010.06.041
		46890239	6934	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	370	6	3	6	2.2	CC(Cc1cnn(-c2ccc(O)cn2)c1)C(=O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.013
		CHEMBL1084448	6934	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	370	6	3	6	2.2	CC(Cc1cnn(-c2ccc(O)cn2)c1)C(=O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.013
		12003788	194941	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	278	2	2	2	2.7	O=C(O)c1n[nH]c2c1CC(c1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.06.054
		CHEMBL1237148	194941	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	278	2	2	2	2.7	O=C(O)c1n[nH]c2c1CC(c1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.06.054
		CHEMBL542000	194941	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	278	2	2	2	2.7	O=C(O)c1n[nH]c2c1CC(c1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.06.054
		136375410	177317	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	370	7	3	7	2.5	CCn1cc(NC(=O)CCc2nc(-c3ccc(O)cc3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		CHEMBL4636989	177317	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	370	7	3	7	2.5	CCn1cc(NC(=O)CCc2nc(-c3ccc(O)cc3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		135899322	16192	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	299	5	1	4	2.2	O=c1[nH]c(COCCc2ccccc2F)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1224146	16192	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	299	5	1	4	2.2	O=c1[nH]c(COCCc2ccccc2F)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		16048923	94656	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	376	3	2	4	3.3	O=C(O)c1ccccc1NC(=O)N1CCN(c2nccc3ccccc23)CC1	10.1016/j.bmcl.2007.10.055
		CHEMBL252506	94656	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	376	3	2	4	3.3	O=C(O)c1ccccc1NC(=O)N1CCN(c2nccc3ccccc23)CC1	10.1016/j.bmcl.2007.10.055
		137661033	159487	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	313	4	3	3	2.6	O=C(CCC#Cc1ccccc1O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4101720	159487	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	313	4	3	3	2.6	O=C(CCC#Cc1ccccc1O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		122181140	121828	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	379	6	3	3	4.5	O=C(CCc1ccc(-c2ccc(O)cc2F)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		CHEMBL3589834	121828	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	379	6	3	3	4.5	O=C(CCc1ccc(-c2ccc(O)cc2F)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		15986930	184910	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	371	5	3	6	2.8	O=C(CCc1cn2c(n1)sc1cc(O)ccc12)NC1=C(C(=O)O)CCC1	10.1021/jm900151e
		CHEMBL485327	184910	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	371	5	3	6	2.8	O=C(CCc1cn2c(n1)sc1cc(O)ccc12)NC1=C(C(=O)O)CCC1	10.1021/jm900151e
		156019027	177797	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	415	8	3	5	4.5	CCCCn1cc(C(=O)O)c(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)n1	10.1016/j.bmcl.2020.127105
		CHEMBL4643451	177797	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	415	8	3	5	4.5	CCCCn1cc(C(=O)O)c(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)n1	10.1016/j.bmcl.2020.127105
		135899198	15591	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	299	5	1	4	2.2	O=c1[nH]c(COCCc2cccc(F)c2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1221438	15591	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	299	5	1	4	2.2	O=c1[nH]c(COCCc2cccc(F)c2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		135899170	16172	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccc(Cl)cc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1224072	16172	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccc(Cl)cc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		24741307	88735	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	365	6	3	5	3.2	Cc1c(CCC(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cc1	10.1016/j.bmcl.2010.04.013
		CHEMBL236163	88735	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	365	6	3	5	3.2	Cc1c(CCC(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cc1	10.1016/j.bmcl.2010.04.013
		24741307	88735	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	365	6	3	5	3.2	Cc1c(CCC(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cc1	10.1021/jm700942d
		CHEMBL236163	88735	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	365	6	3	5	3.2	Cc1c(CCC(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cc1	10.1021/jm700942d
		11660694	178068	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	369	5	3	3	4.5	O=C(CCc1ccc2c(Cl)c(O)ccc2c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2020.127105
		CHEMBL4647392	178068	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	369	5	3	3	4.5	O=C(CCc1ccc2c(Cl)c(O)ccc2c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2020.127105
		11493732	193100	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	335	5	3	3	3.8	O=C(CCc1ccc2cc(O)ccc2c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2008.08.030
		CHEMBL522649	193100	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	335	5	3	3	3.8	O=C(CCc1ccc2cc(O)ccc2c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2008.08.030
		12003596	14977	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	234	2	2	3	2.1	O=C(O)c1n[nH]c2c1CC(c1cccs1)C2	10.1016/j.bmcl.2010.06.041
		CHEMBL1208924	14977	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	234	2	2	3	2.1	O=C(O)c1n[nH]c2c1CC(c1cccs1)C2	10.1016/j.bmcl.2010.06.041
		12002619	184180	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c(F)c1	10.1016/j.bmcl.2009.03.014
		CHEMBL483141	184180	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c(F)c1	10.1016/j.bmcl.2009.03.014
		117629482	2823	140	None	-3	2	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmc.2015.02.018
		1588	2823	140	None	-3	2	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmc.2015.02.018
		1594	2823	140	None	-3	2	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmc.2015.02.018
		2835	2823	140	None	-3	2	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmc.2015.02.018
		938	2823	140	None	-3	2	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmc.2015.02.018
		CHEMBL573	2823	140	None	-3	2	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmc.2015.02.018
		DB00627	2823	140	None	-3	2	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmc.2015.02.018
		46890197	7259	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	366	6	3	6	2.5	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		CHEMBL1085875	7259	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	366	6	3	6	2.5	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		137633734	156321	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	311	3	3	3	2.3	O=C(/C=C/C#Cc1ccc(O)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4065654	156321	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	311	3	3	3	2.3	O=C(/C=C/C#Cc1ccc(O)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		49862072	14972	0	None	-	0	Mouse	6.6	pIC50	=	6.6	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	194	3	2	2	1.6	CCCC1Cc2[nH]nc(C(=O)O)c2C1	10.1016/j.bmcl.2010.06.041
		CHEMBL1208919	14972	0	None	-	0	Mouse	6.6	pIC50	=	6.6	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	194	3	2	2	1.6	CCCC1Cc2[nH]nc(C(=O)O)c2C1	10.1016/j.bmcl.2010.06.041
		12003596	14977	0	None	-	0	Mouse	6.6	pIC50	=	6.6	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	234	2	2	3	2.1	O=C(O)c1n[nH]c2c1CC(c1cccs1)C2	10.1016/j.bmcl.2010.06.041
		CHEMBL1208924	14977	0	None	-	0	Mouse	6.6	pIC50	=	6.6	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	234	2	2	3	2.1	O=C(O)c1n[nH]c2c1CC(c1cccs1)C2	10.1016/j.bmcl.2010.06.041
		135899131	16135	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	315	6	1	5	2.3	O=c1[nH]c(OCCCOc2ccccc2F)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1223959	16135	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	315	6	1	5	2.3	O=c1[nH]c(OCCCOc2ccccc2F)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		16048998	94632	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	376	3	2	4	3.3	O=C(O)c1ccccc1NC(=O)N1CCN(c2ccc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
		CHEMBL252307	94632	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	376	3	2	4	3.3	O=C(O)c1ccccc1NC(=O)N1CCN(c2ccc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
		11299550	192007	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	244	2	2	4	1.5	C1CCC(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)C1	10.1016/j.bmcl.2009.03.014
		CHEMBL520159	192007	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	244	2	2	4	1.5	C1CCC(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)C1	10.1016/j.bmcl.2009.03.014
		44591602	188384	0	None	-	0	Mouse	5.6	pIC50	=	5.6	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	216	2	2	4	0.7	C1CC1C1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL501585	188384	0	None	-	0	Mouse	5.6	pIC50	=	5.6	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	216	2	2	4	0.7	C1CC1C1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		15986936	7101	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	356	6	3	6	1.9	O=C(CCc1cnn(-c2ccc(O)cn2)c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.013
		CHEMBL1085150	7101	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	356	6	3	6	1.9	O=C(CCc1cnn(-c2ccc(O)cn2)c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.013
		15986929	7159	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	383	6	3	5	3.1	Cc1c(CC(C)C(=O)NC2=C(C(=O)O)CCCC2)cnn1-c1ccc(O)cc1	10.1016/j.bmcl.2010.04.013
		CHEMBL1085402	7159	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	383	6	3	5	3.1	Cc1c(CC(C)C(=O)NC2=C(C(=O)O)CCCC2)cnn1-c1ccc(O)cc1	10.1016/j.bmcl.2010.04.013
		135800176	89400	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	369	6	3	6	3.2	O=C(CCc1cnc(-c2ccc(O)cn2)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		CHEMBL237037	89400	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	369	6	3	6	3.2	O=C(CCc1cnc(-c2ccc(O)cn2)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		46890164	7422	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	335	6	2	4	3.1	O=C(CCc1cnn(-c2ccccc2)c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		CHEMBL1086568	7422	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	335	6	2	4	3.1	O=C(CCc1cnn(-c2ccccc2)c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		11424509	188288	0	None	-	0	Mouse	6.6	pIC50	=	6.6	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	218	3	2	4	1.1	CCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL500239	188288	0	None	-	0	Mouse	6.6	pIC50	=	6.6	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	218	3	2	4	1.1	CCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		156021546	178186	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	401	9	4	9	1.3	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1cn(CCCO)cc1C(=O)O	10.1016/j.bmcl.2020.127105
		CHEMBL4649305	178186	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	401	9	4	9	1.3	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1cn(CCCO)cc1C(=O)O	10.1016/j.bmcl.2020.127105
		12003785	196379	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	260	2	2	2	2.5	O=C(O)c1n[nH]c2c1CC(c1ccccc1F)CC2	10.1016/j.bmcl.2009.06.054
		CHEMBL562632	196379	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	260	2	2	2	2.5	O=C(O)c1n[nH]c2c1CC(c1ccccc1F)CC2	10.1016/j.bmcl.2009.06.054
		12002520	184153	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	270	2	2	4	1.6	Fc1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)cc1	10.1016/j.bmcl.2009.03.014
		CHEMBL482943	184153	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	270	2	2	4	1.6	Fc1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)cc1	10.1016/j.bmcl.2009.03.014
		135899325	16193	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of radioligand from rat GPR109ADisplacement of radioligand from rat GPR109A	ChEMBL	299	5	1	4	2.2	O=c1[nH]c(COCCc2ccc(F)cc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1224147	16193	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of radioligand from rat GPR109ADisplacement of radioligand from rat GPR109A	ChEMBL	299	5	1	4	2.2	O=c1[nH]c(COCCc2ccc(F)cc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		17751630	6745	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	487	7	3	7	2.8	NC(Cc1nc(-c2ccc(F)cn2)no1)C(=O)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1083743	6745	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	487	7	3	7	2.8	NC(Cc1nc(-c2ccc(F)cn2)no1)C(=O)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
		137635425	155922	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	331	4	3	3	2.7	O=C(CCC#Cc1ccc(O)cc1F)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4060899	155922	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	331	4	3	3	2.7	O=C(CCC#Cc1ccc(O)cc1F)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		46890579	7016	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	455	7	2	7	3.2	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CC(c2ccc(F)nc2)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1084798	7016	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	455	7	2	7	3.2	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CC(c2ccc(F)nc2)CC1	10.1016/j.bmcl.2010.04.001
		137662135	159350	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	367	6	2	2	4.5	O=C(CCc1ccc(-c2ccccc2F)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4100231	159350	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	367	6	2	2	4.5	O=C(CCc1ccc(-c2ccccc2F)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		137645601	157851	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	299	6	2	2	3.2	O=C(/C=C/CCc1ccccc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4083723	157851	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	299	6	2	2	3.2	O=C(/C=C/CCc1ccccc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		11559598	121811	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	363	6	2	2	4.8	O=C(CCc1ccc(-c2cccc(F)c2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		CHEMBL3589785	121811	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	363	6	2	2	4.8	O=C(CCc1ccc(-c2cccc(F)c2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		11660694	178068	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Agonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysisAgonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysis	ChEMBL	369	5	3	3	4.5	O=C(CCc1ccc2c(Cl)c(O)ccc2c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2020.127105
		CHEMBL4647392	178068	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Agonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysisAgonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysis	ChEMBL	369	5	3	3	4.5	O=C(CCc1ccc2c(Cl)c(O)ccc2c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2020.127105
		11617151	88639	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	345	6	2	2	4.6	O=C(CCc1ccc(-c2ccccc2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		CHEMBL235741	88639	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	345	6	2	2	4.6	O=C(CCc1ccc(-c2ccccc2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		16048919	94683	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	407	4	2	6	2.7	COc1cccc2nc(N3CCN(C(=O)Nc4ccccc4C(=O)O)CC3)cnc12	10.1016/j.bmcl.2007.10.055
		CHEMBL252708	94683	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	407	4	2	6	2.7	COc1cccc2nc(N3CCN(C(=O)Nc4ccccc4C(=O)O)CC3)cnc12	10.1016/j.bmcl.2007.10.055
		12002522	188456	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	286	2	2	4	2.1	Clc1cccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		CHEMBL502716	188456	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	286	2	2	4	2.1	Clc1cccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		137653428	158543	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	315	4	2	2	3.0	O=C(CCC#Cc1ccc(F)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4091542	158543	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	315	4	2	2	3.0	O=C(CCC#Cc1ccc(F)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		42625474	184178	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	380	5	3	5	3.6	O=C(CCc1noc2c1ccc1cc(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
		CHEMBL483139	184178	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	380	5	3	5	3.6	O=C(CCc1noc2c1ccc1cc(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
		42625379	192091	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	376	5	3	5	4.0	O=C(CCc1noc2c1ccc1cc(O)ccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
		CHEMBL520299	192091	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	376	5	3	5	4.0	O=C(CCc1noc2c1ccc1cc(O)ccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
		46890327	6600	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	451	6	3	3	5.2	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1083138	6600	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	451	6	3	3	5.2	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
		135416388	7524	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	358	6	3	7	1.8	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.11.116
		CHEMBL1087302	7524	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	358	6	3	7	1.8	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.11.116
		12003490	14976	0	None	-	0	Mouse	7.5	pIC50	=	7.5	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	282	2	2	2	2.4	O=C(O)c1n[nH]c2c1CC(c1cc(F)cc(F)c1F)C2	10.1016/j.bmcl.2010.06.041
		CHEMBL1208923	14976	0	None	-	0	Mouse	7.5	pIC50	=	7.5	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	282	2	2	2	2.4	O=C(O)c1n[nH]c2c1CC(c1cc(F)cc(F)c1F)C2	10.1016/j.bmcl.2010.06.041
		42625213	192303	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	365	5	2	5	3.8	O=C(CCc1cn2c(n1)sc1ccccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
		CHEMBL520620	192303	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	365	5	2	5	3.8	O=C(CCc1cn2c(n1)sc1ccccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
		46890163	7421	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	335	6	2	4	3.1	O=C(CCc1ccn(-c2ccccc2)n1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		CHEMBL1086567	7421	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	335	6	2	4	3.1	O=C(CCc1ccn(-c2ccccc2)n1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		12003879	192342	0	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	252	2	2	4	1.5	c1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)cc1	10.1016/j.bmcl.2009.03.014
		CHEMBL520675	192342	0	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	252	2	2	4	1.5	c1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)cc1	10.1016/j.bmcl.2009.03.014
		156020475	178074	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	429	8	3	5	4.5	CCCCc1nc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)n1C	10.1016/j.bmcl.2020.127105
		CHEMBL4647545	178074	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	429	8	3	5	4.5	CCCCc1nc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)n1C	10.1016/j.bmcl.2020.127105
		12002523	171949	0	None	-	0	Mouse	5.5	pIC50	=	5.5	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	286	2	2	4	2.1	Clc1ccccc1C1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL447050	171949	0	None	-	0	Mouse	5.5	pIC50	=	5.5	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	286	2	2	4	2.1	Clc1ccccc1C1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		46890165	7314	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	351	6	3	5	2.8	O=C(CCc1cnn(-c2ccc(O)cc2)c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		CHEMBL1086103	7314	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	351	6	3	5	2.8	O=C(CCc1cnn(-c2ccc(O)cc2)c1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		46890501	7246	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	375	6	3	7	1.2	NC(Cc1nc(-c2ccc(F)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1085816	7246	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	375	6	3	7	1.2	NC(Cc1nc(-c2ccc(F)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.001
		137647495	157856	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	365	6	3	3	4.0	O=C(CCc1ccc(-c2cccc(O)c2)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4083762	157856	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	365	6	3	3	4.0	O=C(CCc1ccc(-c2cccc(O)c2)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		11508815	121807	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	363	6	2	2	4.8	O=C(CCc1ccc(-c2ccc(F)cc2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		CHEMBL3589779	121807	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	363	6	2	2	4.8	O=C(CCc1ccc(-c2ccc(F)cc2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		122181104	121815	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	413	6	2	2	5.6	O=C(CCc1ccc(-c2ccccc2C(F)(F)F)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		CHEMBL3589789	121815	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	413	6	2	2	5.6	O=C(CCc1ccc(-c2ccccc2C(F)(F)F)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		90645405	112533	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	295	3	2	2	2.6	O=C(/C=C/C#Cc1ccccc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL3299113	112533	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	295	3	2	2	2.6	O=C(/C=C/C#Cc1ccccc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		136127016	16171	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2cccc(Cl)c2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1224071	16171	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2cccc(Cl)c2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		135800175	88736	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	353	6	3	6	2.7	O=C(CCc1nnc(-c2ccc(O)cc2)o1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		CHEMBL236164	88736	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	353	6	3	6	2.7	O=C(CCc1nnc(-c2ccc(O)cc2)o1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		44579763	186983	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	428	7	1	5	5.0	Cc1c(C(=O)N[C@@H](C)COc2ccccc2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
		CHEMBL490600	186983	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	428	7	1	5	5.0	Cc1c(C(=O)N[C@@H](C)COc2ccccc2)cnc2c(-c3ccc(C(C)C)cc3)cnn12	10.1016/j.bmcl.2008.08.039
		137652577	158760	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	329	3	3	3	2.5	O=C(/C=C/C#Cc1ccc(O)cc1F)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4093990	158760	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	329	3	3	3	2.5	O=C(/C=C/C#Cc1ccc(O)cc1F)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		11560300	88539	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	395	6	3	3	5.0	O=C(CCc1ccc(-c2ccc(O)cc2Cl)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		CHEMBL235256	88539	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	395	6	3	3	5.0	O=C(CCc1ccc(-c2ccc(O)cc2Cl)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		24811547	7376	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	415	6	3	3	4.9	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccccc2)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1086355	7376	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	415	6	3	3	4.9	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccccc2)CC1	10.1016/j.bmcl.2010.04.001
		11638560	187043	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	334	5	3	3	3.7	Nc1ccc2cc(CCC(=O)Nc3ccccc3C(=O)O)ccc2c1	10.1016/j.bmcl.2008.08.030
		CHEMBL491002	187043	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	334	5	3	3	3.7	Nc1ccc2cc(CCC(=O)Nc3ccccc3C(=O)O)ccc2c1	10.1016/j.bmcl.2008.08.030
		42625382	184812	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	416	5	3	5	3.7	Cn1c(=O)c2cc(O)ccc2c2ccc(CCC(=O)Nc3ccccc3C(=O)O)cc21	10.1021/jm900151e
		CHEMBL485184	184812	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	416	5	3	5	3.7	Cn1c(=O)c2cc(O)ccc2c2ccc(CCC(=O)Nc3ccccc3C(=O)O)cc21	10.1021/jm900151e
		11736428	189063	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	232	4	2	4	1.5	CCCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL509541	189063	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	232	4	2	4	1.5	CCCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		12003880	188734	0	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	270	2	2	4	1.6	Fc1ccccc1C1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL504980	188734	0	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	270	2	2	4	1.6	Fc1ccccc1C1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		44580007	186947	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	366	6	1	5	3.6	COCC(C)NC(=O)c1cnc2c(-c3ccc(C(C)C)cc3)cnn2c1C	10.1016/j.bmcl.2008.08.039
		CHEMBL490215	186947	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells	ChEMBL	366	6	1	5	3.6	COCC(C)NC(=O)c1cnc2c(-c3ccc(C(C)C)cc3)cnn2c1C	10.1016/j.bmcl.2008.08.039
		12003601	14980	0	None	-	0	Mouse	5.5	pIC50	=	5.5	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	218	2	2	4	0.6	O=C(O)c1n[nH]c2c1CC(n1cccn1)C2	10.1016/j.bmcl.2010.06.041
		CHEMBL1208987	14980	0	None	-	0	Mouse	5.5	pIC50	=	5.5	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	218	2	2	4	0.6	O=C(O)c1n[nH]c2c1CC(n1cccn1)C2	10.1016/j.bmcl.2010.06.041
		135399731	184157	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	391	5	3	5	3.2	Cn1nc2c(c1CCC(=O)Nc1ccccc1C(=O)O)CCc1cc(O)ccc1-2	10.1021/jm900151e
		CHEMBL482963	184157	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	391	5	3	5	3.2	Cn1nc2c(c1CCC(=O)Nc1ccccc1C(=O)O)CCc1cc(O)ccc1-2	10.1021/jm900151e
		46890500	7245	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	360	6	2	6	2.2	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1085815	7245	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	360	6	2	6	2.2	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.001
		24741306	166956	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	334	6	3	2	4.0	O=C(CCc1ccc(-c2ccc[nH]2)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		CHEMBL428724	166956	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	334	6	3	2	4.0	O=C(CCc1ccc(-c2ccc[nH]2)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		46890401	7287	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	460	7	3	4	4.9	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)NC1=C(C(=O)O)CC(c2cccnc2F)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1086031	7287	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	460	7	3	4	4.9	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)NC1=C(C(=O)O)CC(c2cccnc2F)CC1	10.1016/j.bmcl.2010.04.001
		42625380	184411	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	407	5	3	8	1.6	Cn1c(=O)c2c(CCC(=O)Nc3ccccc3C(=O)O)nnn2c2ccc(O)cc21	10.1021/jm900151e
		CHEMBL484605	184411	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	407	5	3	8	1.6	Cn1c(=O)c2c(CCC(=O)Nc3ccccc3C(=O)O)nnn2c2ccc(O)cc21	10.1021/jm900151e
		44591586	184161	0	None	-	0	Mouse	5.4	pIC50	=	5.4	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	246	5	2	4	1.9	CCCCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL482979	184161	0	None	-	0	Mouse	5.4	pIC50	=	5.4	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	246	5	2	4	1.9	CCCCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		137648318	157632	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	341	5	3	3	2.5	O=C(CCC#Cc1ccc(C(=O)O)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4081260	157632	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	341	5	3	3	2.5	O=C(CCC#Cc1ccc(C(=O)O)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		122181106	121818	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	395	6	3	3	5.0	O=C(CCc1ccc(-c2ccc(O)c(Cl)c2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		CHEMBL3589792	121818	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	395	6	3	3	5.0	O=C(CCc1ccc(-c2ccc(O)c(Cl)c2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		137632012	156656	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	311	3	3	3	2.3	O=C(/C=C/C#Cc1ccccc1O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4069406	156656	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	311	3	3	3	2.3	O=C(/C=C/C#Cc1ccccc1O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		12003791	194829	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
		CHEMBL1237147	194829	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
		CHEMBL539398	194829	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
		136127015	16132	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	279	4	1	4	2.4	O=c1[nH]c(OC/C=C/c2ccccc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1223956	16132	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	279	4	1	4	2.4	O=c1[nH]c(OC/C=C/c2ccccc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		135899149	16137	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	315	6	1	5	2.3	O=c1[nH]c(OCCCOc2cccc(F)c2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1223960	16137	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	315	6	1	5	2.3	O=c1[nH]c(OCCCOc2cccc(F)c2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		135922723	184162	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	364	5	3	5	3.2	O=C(CCc1noc2c1Cc1cc(O)ccc1-2)Nc1ccccc1C(=O)O	10.1021/jm900151e
		CHEMBL482980	184162	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	364	5	3	5	3.2	O=C(CCc1noc2c1Cc1cc(O)ccc1-2)Nc1ccccc1C(=O)O	10.1021/jm900151e
		49862072	14972	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	194	3	2	2	1.6	CCCC1Cc2[nH]nc(C(=O)O)c2C1	10.1016/j.bmcl.2010.06.041
		CHEMBL1208919	14972	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	194	3	2	2	1.6	CCCC1Cc2[nH]nc(C(=O)O)c2C1	10.1016/j.bmcl.2010.06.041
		137654580	159022	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	311	3	3	3	2.3	O=C(/C=C/C#Cc1cccc(O)c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4096635	159022	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	311	3	3	3	2.3	O=C(/C=C/C#Cc1cccc(O)c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		12003694	1144	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	232	2	2	4	0.7	OC(=O)c1n[nH]c2c1CC(C2)c1ccnn1C	10.1016/j.bmcl.2010.06.041
		5793	1144	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	232	2	2	4	0.7	OC(=O)c1n[nH]c2c1CC(C2)c1ccnn1C	10.1016/j.bmcl.2010.06.041
		CHEMBL1208986	1144	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	232	2	2	4	0.7	OC(=O)c1n[nH]c2c1CC(C2)c1ccnn1C	10.1016/j.bmcl.2010.06.041
		156017987	177919	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	358	5	3	4	3.4	O=C(CCc1ccc2c(Cl)c(O)ccc2c1)Nn1cccc1C(=O)O	10.1016/j.bmcl.2020.127105
		CHEMBL4645273	177919	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	358	5	3	4	3.4	O=C(CCc1ccc2c(Cl)c(O)ccc2c1)Nn1cccc1C(=O)O	10.1016/j.bmcl.2020.127105
		11560300	88539	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	395	6	3	3	5.0	O=C(CCc1ccc(-c2ccc(O)cc2Cl)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		CHEMBL235256	88539	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	395	6	3	3	5.0	O=C(CCc1ccc(-c2ccc(O)cc2Cl)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		11560300	88539	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	395	6	3	3	5.0	O=C(CCc1ccc(-c2ccc(O)cc2Cl)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		CHEMBL235256	88539	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	395	6	3	3	5.0	O=C(CCc1ccc(-c2ccc(O)cc2Cl)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		135800194	89491	0	None	-	1	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	354	6	3	7	2.1	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		CHEMBL237248	89491	0	None	-	1	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	354	6	3	7	2.1	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		135466520	184217	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	378	5	3	5	3.4	O=C(CCc1noc2c1CCc1cc(O)ccc1-2)Nc1ccccc1C(=O)O	10.1021/jm900151e
		CHEMBL483353	184217	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	378	5	3	5	3.4	O=C(CCc1noc2c1CCc1cc(O)ccc1-2)Nc1ccccc1C(=O)O	10.1021/jm900151e
		135416384	184824	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	382	5	3	5	3.1	O=C(CCc1noc2c1CCc1cc(O)ccc1-2)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
		CHEMBL485196	184824	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	382	5	3	5	3.1	O=C(CCc1noc2c1CCc1cc(O)ccc1-2)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
		136086823	6969	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	400	8	3	7	2.8	CCCC1CCC(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
		CHEMBL1084576	6969	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	400	8	3	7	2.8	CCCC1CCC(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
		135416388	7524	0	None	-	1	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	358	6	3	7	1.8	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1087302	7524	0	None	-	1	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	358	6	3	7	1.8	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.001
		136088958	61446	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	369	6	4	8	1.0	N[C@H](Cc1nc(-c2ccc(O)cn2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		CHEMBL1770353	61446	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	369	6	4	8	1.0	N[C@H](Cc1nc(-c2ccc(O)cn2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		12002618	191991	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	306	2	2	4	1.9	Fc1cc(F)c(F)c(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		CHEMBL520137	191991	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	306	2	2	4	1.9	Fc1cc(F)c(F)c(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		12002618	191991	0	None	-	0	Mouse	7.4	pIC50	=	7.4	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	306	2	2	4	1.9	Fc1cc(F)c(F)c(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		CHEMBL520137	191991	0	None	-	0	Mouse	7.4	pIC50	=	7.4	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	306	2	2	4	1.9	Fc1cc(F)c(F)c(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		137650474	157279	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	365	6	3	3	4.0	O=C(CCc1ccc(-c2ccccc2O)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4076822	157279	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	365	6	3	3	4.0	O=C(CCc1ccc(-c2ccccc2O)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		12003788	194941	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	278	2	2	2	2.7	O=C(O)c1n[nH]c2c1CC(c1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.06.054
		CHEMBL1237148	194941	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	278	2	2	2	2.7	O=C(O)c1n[nH]c2c1CC(c1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.06.054
		CHEMBL542000	194941	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	278	2	2	2	2.7	O=C(O)c1n[nH]c2c1CC(c1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.06.054
		136127010	16086	11	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Displacement of radioligand from rat GPR109ADisplacement of radioligand from rat GPR109A	ChEMBL	215	0	1	3	1.3	O=c1[nH]c(C(F)(F)F)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1223819	16086	11	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Displacement of radioligand from rat GPR109ADisplacement of radioligand from rat GPR109A	ChEMBL	215	0	1	3	1.3	O=c1[nH]c(C(F)(F)F)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		156020831	178070	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	386	8	4	8	1.5	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1cn(CCO)cc1C(=O)O	10.1016/j.bmcl.2020.127105
		CHEMBL4647398	178070	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	386	8	4	8	1.5	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1cn(CCO)cc1C(=O)O	10.1016/j.bmcl.2020.127105
		12003692	14981	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	219	2	2	5	0.0	O=C(O)c1n[nH]c2c1CC(n1ccnn1)C2	10.1016/j.bmcl.2010.06.041
		CHEMBL1208988	14981	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	219	2	2	5	0.0	O=C(O)c1n[nH]c2c1CC(n1ccnn1)C2	10.1016/j.bmcl.2010.06.041
		44591604	184823	0	None	-	0	Mouse	5.4	pIC50	=	5.4	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	286	2	2	4	2.1	Clc1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)cc1	10.1016/j.bmcl.2009.03.014
		CHEMBL485195	184823	0	None	-	0	Mouse	5.4	pIC50	=	5.4	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	286	2	2	4	2.1	Clc1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)cc1	10.1016/j.bmcl.2009.03.014
		136088962	61401	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	368	6	4	7	1.6	N[C@H](Cc1nc(-c2ccc(O)cc2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		CHEMBL1770176	61401	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	368	6	4	7	1.6	N[C@H](Cc1nc(-c2ccc(O)cc2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		156016157	177778	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	430	8	3	4	3.2	CCCCN1CC(C(=O)O)=C(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)C1=O	10.1016/j.bmcl.2020.127105
		CHEMBL4643073	177778	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	430	8	3	4	3.2	CCCCN1CC(C(=O)O)=C(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)C1=O	10.1016/j.bmcl.2020.127105
		12003880	188734	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	270	2	2	4	1.6	Fc1ccccc1C1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL504980	188734	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	270	2	2	4	1.6	Fc1ccccc1C1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		136127017	16213	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	295	5	1	4	2.4	Cc1cccc(CCOCc2nc3ncccc3c(=O)[nH]2)c1	10.1016/j.bmcl.2010.07.108
		CHEMBL1224222	16213	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	295	5	1	4	2.4	Cc1cccc(CCOCc2nc3ncccc3c(=O)[nH]2)c1	10.1016/j.bmcl.2010.07.108
		136000579	61400	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	368	6	4	7	1.6	N[C@@H](Cc1nc(-c2ccc(O)cc2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		CHEMBL1770175	61400	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	368	6	4	7	1.6	N[C@@H](Cc1nc(-c2ccc(O)cc2)no1)C(=O)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		46890271	7377	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	355	5	4	4	2.5	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(O)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1086356	7377	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	355	5	4	4	2.5	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(O)CC1	10.1016/j.bmcl.2010.04.001
		12002521	184821	0	None	-	0	Mouse	5.4	pIC50	=	5.4	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	266	2	2	4	1.8	Cc1ccccc1C1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL485194	184821	0	None	-	0	Mouse	5.4	pIC50	=	5.4	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	266	2	2	4	1.8	Cc1ccccc1C1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		46890268	6606	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	353	5	3	3	3.8	CC1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
		CHEMBL1083174	6606	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	353	5	3	3	3.8	CC1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
		12003879	192342	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	252	2	2	4	1.5	c1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)cc1	10.1016/j.bmcl.2009.03.014
		CHEMBL520675	192342	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	252	2	2	4	1.5	c1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)cc1	10.1016/j.bmcl.2009.03.014
		135899109	16214	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	295	5	1	4	2.4	Cc1ccc(CCOCc2nc3ncccc3c(=O)[nH]2)cc1	10.1016/j.bmcl.2010.07.108
		CHEMBL1224223	16214	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	295	5	1	4	2.4	Cc1ccc(CCOCc2nc3ncccc3c(=O)[nH]2)cc1	10.1016/j.bmcl.2010.07.108
		135899153	16212	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	295	5	1	4	2.4	Cc1ccccc1CCOCc1nc2ncccc2c(=O)[nH]1	10.1016/j.bmcl.2010.07.108
		CHEMBL1224221	16212	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	295	5	1	4	2.4	Cc1ccccc1CCOCc1nc2ncccc2c(=O)[nH]1	10.1016/j.bmcl.2010.07.108
		135899247	16088	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	279	5	1	3	2.9	O=c1[nH]c(CCCCc2ccccc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1223823	16088	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	279	5	1	3	2.9	O=c1[nH]c(CCCCc2ccccc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		135899110	16228	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	311	6	1	5	2.1	COc1ccc(CCOCc2nc3ncccc3c(=O)[nH]2)cc1	10.1016/j.bmcl.2010.07.108
		CHEMBL1224294	16228	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	311	6	1	5	2.1	COc1ccc(CCOCc2nc3ncccc3c(=O)[nH]2)cc1	10.1016/j.bmcl.2010.07.108
		12003694	1144	0	None	-	0	Mouse	6.4	pIC50	=	6.4	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	232	2	2	4	0.7	OC(=O)c1n[nH]c2c1CC(C2)c1ccnn1C	10.1016/j.bmcl.2010.06.041
		5793	1144	0	None	-	0	Mouse	6.4	pIC50	=	6.4	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	232	2	2	4	0.7	OC(=O)c1n[nH]c2c1CC(C2)c1ccnn1C	10.1016/j.bmcl.2010.06.041
		CHEMBL1208986	1144	0	None	-	0	Mouse	6.4	pIC50	=	6.4	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	232	2	2	4	0.7	OC(=O)c1n[nH]c2c1CC(C2)c1ccnn1C	10.1016/j.bmcl.2010.06.041
		135812996	16173	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	311	6	1	5	2.5	Cc1ccccc1OCCCOc1nc2ncccc2c(=O)[nH]1	10.1016/j.bmcl.2010.07.108
		CHEMBL1224073	16173	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	311	6	1	5	2.5	Cc1ccccc1OCCCOc1nc2ncccc2c(=O)[nH]1	10.1016/j.bmcl.2010.07.108
		46890238	7100	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	384	6	3	6	2.5	Cc1c(CC(C)C(=O)NC2=C(C(=O)O)CCCC2)cnn1-c1ccc(O)cn1	10.1016/j.bmcl.2010.04.013
		CHEMBL1085149	7100	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	384	6	3	6	2.5	Cc1c(CC(C)C(=O)NC2=C(C(=O)O)CCCC2)cnn1-c1ccc(O)cn1	10.1016/j.bmcl.2010.04.013
		12003790	196055	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	276	2	2	2	3.0	O=C(O)c1n[nH]c2c1CC(c1ccccc1Cl)CC2	10.1016/j.bmcl.2009.06.054
		CHEMBL560406	196055	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	276	2	2	2	3.0	O=C(O)c1n[nH]c2c1CC(c1ccccc1Cl)CC2	10.1016/j.bmcl.2009.06.054
		135800177	145951	7	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Displacement of [3H]niacin from mouse GPR109ADisplacement of [3H]niacin from mouse GPR109A	ChEMBL	353	6	3	6	2.7	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		CHEMBL391813	145951	7	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Displacement of [3H]niacin from mouse GPR109ADisplacement of [3H]niacin from mouse GPR109A	ChEMBL	353	6	3	6	2.7	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		156016715	177675	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	415	8	3	5	4.5	CCCCn1cc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)n1	10.1016/j.bmcl.2020.127105
		CHEMBL4641756	177675	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	415	8	3	5	4.5	CCCCn1cc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)n1	10.1016/j.bmcl.2020.127105
		11183317	191470	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	204	2	2	4	0.7	CCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL519338	191470	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	204	2	2	4	0.7	CCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		135899130	16175	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	311	6	1	5	2.5	Cc1ccc(OCCCOc2nc3ncccc3c(=O)[nH]2)cc1	10.1016/j.bmcl.2010.07.108
		CHEMBL1224075	16175	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	311	6	1	5	2.5	Cc1ccc(OCCCOc2nc3ncccc3c(=O)[nH]2)cc1	10.1016/j.bmcl.2010.07.108
		44591586	184161	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	246	5	2	4	1.9	CCCCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL482979	184161	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	246	5	2	4	1.9	CCCCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		136127012	16113	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	321	8	1	3	4.1	O=c1[nH]c(CCCCCCCc2ccccc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1223876	16113	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	321	8	1	3	4.1	O=c1[nH]c(CCCCCCCc2ccccc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		46890240	7103	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	356	6	3	6	1.9	O=C(CCc1ccn(-c2ccc(O)cn2)n1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.013
		CHEMBL1085156	7103	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	356	6	3	6	1.9	O=C(CCc1ccn(-c2ccc(O)cn2)n1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.013
		46890301	7199	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	482	7	3	6	3.9	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1	10.1016/j.bmcl.2010.04.013
		CHEMBL1085616	7199	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	482	7	3	6	3.9	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1	10.1016/j.bmcl.2010.04.013
		11516324	184216	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	375	5	4	4	3.7	O=C(CCc1[nH]nc2c1ccc1cc(O)ccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
		CHEMBL483352	184216	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	375	5	4	4	3.7	O=C(CCc1[nH]nc2c1ccc1cc(O)ccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
		15986931	192236	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	385	5	3	6	3.2	O=C(CCc1cn2c(n1)sc1cc(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
		CHEMBL520513	192236	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	385	5	3	6	3.2	O=C(CCc1cn2c(n1)sc1cc(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
		136088960	61448	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	373	6	4	8	0.7	N[C@@H](Cc1nc(-c2ccc(O)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.11.116
		CHEMBL1770355	61448	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	373	6	4	8	0.7	N[C@@H](Cc1nc(-c2ccc(O)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.11.116
		135899178	16210	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	315	5	1	4	2.7	O=c1[nH]c(COCCc2cccc(Cl)c2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1224219	16210	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	315	5	1	4	2.7	O=c1[nH]c(COCCc2cccc(Cl)c2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		12002802	195833	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	285	2	2	5	1.4	Fc1ncccc1C1CCc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.06.054
		CHEMBL558334	195833	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	285	2	2	5	1.4	Fc1ncccc1C1CCc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.06.054
		117629482	2823	140	None	-3	2	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
		1588	2823	140	None	-3	2	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
		1594	2823	140	None	-3	2	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
		2835	2823	140	None	-3	2	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
		938	2823	140	None	-3	2	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
		CHEMBL573	2823	140	None	-3	2	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
		DB00627	2823	140	None	-3	2	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2020.127105
		44591604	184823	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	286	2	2	4	2.1	Clc1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)cc1	10.1016/j.bmcl.2009.03.014
		CHEMBL485195	184823	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	286	2	2	4	2.1	Clc1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)cc1	10.1016/j.bmcl.2009.03.014
		11610363	89490	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	369	6	3	6	3.2	O=C(CCc1ncc(-c2ccc(O)cn2)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		CHEMBL237247	89490	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	369	6	3	6	3.2	O=C(CCc1ncc(-c2ccc(O)cn2)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		156010038	177030	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	414	8	3	4	5.1	CCCCn1cc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		CHEMBL4632359	177030	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	414	8	3	4	5.1	CCCCn1cc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		24811199	6601	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	434	6	3	4	4.4	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2cccnc2F)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1083139	6601	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	434	6	3	4	4.4	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2cccnc2F)CC1	10.1016/j.bmcl.2010.04.001
		12002524	191782	0	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)cc1F	10.1016/j.bmcl.2009.03.014
		CHEMBL519811	191782	0	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)cc1F	10.1016/j.bmcl.2009.03.014
		44591602	188384	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	216	2	2	4	0.7	C1CC1C1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL501585	188384	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	216	2	2	4	0.7	C1CC1C1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		12003692	14981	0	None	-	0	Mouse	5.3	pIC50	=	5.3	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	219	2	2	5	0.0	O=C(O)c1n[nH]c2c1CC(n1ccnn1)C2	10.1016/j.bmcl.2010.06.041
		CHEMBL1208988	14981	0	None	-	0	Mouse	5.3	pIC50	=	5.3	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	219	2	2	5	0.0	O=C(O)c1n[nH]c2c1CC(n1ccnn1)C2	10.1016/j.bmcl.2010.06.041
		44579742	187044	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	347	6	2	3	3.9	O=Cc1ccc2cc(CCC(=O)Nc3ccccc3C(=O)O)ccc2c1	10.1016/j.bmcl.2008.08.030
		CHEMBL491003	187044	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	347	6	2	3	3.9	O=Cc1ccc2cc(CCC(=O)Nc3ccccc3C(=O)O)ccc2c1	10.1016/j.bmcl.2008.08.030
		16048770	94631	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	377	3	2	5	2.7	O=C(O)c1ccccc1NC(=O)N1CCN(c2cnc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
		CHEMBL252306	94631	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	377	3	2	5	2.7	O=C(O)c1ccccc1NC(=O)N1CCN(c2cnc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
		156013148	177468	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	356	6	3	7	2.1	Cn1cc(NC(=O)CCc2nc(-c3ccc(O)cc3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		CHEMBL4639053	177468	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	356	6	3	7	2.1	Cn1cc(NC(=O)CCc2nc(-c3ccc(O)cc3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		11523335	121813	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	359	6	2	2	4.9	Cc1ccccc1-c1ccc(CCC(=O)Nc2ccccc2C(=O)O)cc1	10.1016/j.bmc.2015.02.018
		CHEMBL3589787	121813	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	359	6	2	2	4.9	Cc1ccccc1-c1ccc(CCC(=O)Nc2ccccc2C(=O)O)cc1	10.1016/j.bmc.2015.02.018
		137661636	159263	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	331	4	2	2	3.5	O=C(CCC#Cc1ccccc1Cl)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4099238	159263	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	331	4	2	2	3.5	O=C(CCC#Cc1ccccc1Cl)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		46890537	7038	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	454	7	2	6	3.8	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CC(c2cccc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1084839	7038	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	454	7	2	6	3.8	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CC(c2cccc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
		16048921	155017	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	366	3	2	5	2.9	O=C(O)c1ccccc1NC(=O)N1CCN(c2nc3ccccc3o2)CC1	10.1016/j.bmcl.2007.10.055
		CHEMBL401470	155017	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	366	3	2	5	2.9	O=C(O)c1ccccc1NC(=O)N1CCN(c2nc3ccccc3o2)CC1	10.1016/j.bmcl.2007.10.055
		122181141	121829	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	377	6	4	4	4.0	O=C(CCc1ccc(-c2ccc(O)cc2O)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		CHEMBL3589835	121829	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	377	6	4	4	4.0	O=C(CCc1ccc(-c2ccc(O)cc2O)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		24741310	89622	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	352	6	3	6	2.2	O=C(CCc1ccn(-c2ccc(O)cn2)n1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		CHEMBL237543	89622	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	352	6	3	6	2.2	O=C(CCc1ccn(-c2ccc(O)cn2)n1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.04.013
		24741310	89622	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	352	6	3	6	2.2	O=C(CCc1ccn(-c2ccc(O)cn2)n1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		CHEMBL237543	89622	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	352	6	3	6	2.2	O=C(CCc1ccn(-c2ccc(O)cn2)n1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		137637662	156241	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	383	6	3	3	4.2	O=C(CCc1ccc(-c2ccc(O)cc2F)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4064786	156241	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	383	6	3	3	4.2	O=C(CCc1ccc(-c2ccc(O)cc2F)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		135899244	16111	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	293	6	1	3	3.3	O=c1[nH]c(CCCCCc2ccccc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1223874	16111	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	293	6	1	3	3.3	O=c1[nH]c(CCCCCc2ccccc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		46890300	7415	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	482	7	3	6	3.9	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CCC(c2cccc(F)c2F)C1	10.1016/j.bmcl.2010.04.013
		CHEMBL1086541	7415	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	482	7	3	6	3.9	CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CCC(c2cccc(F)c2F)C1	10.1016/j.bmcl.2010.04.013
		42625218	184179	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	398	5	3	5	3.8	O=C(CCc1noc2c1ccc1c(F)c(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
		CHEMBL483140	184179	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	398	5	3	5	3.8	O=C(CCc1noc2c1ccc1c(F)c(O)ccc12)NC1=C(C(=O)O)CCCC1	10.1021/jm900151e
		46890580	7017	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	504	7	2	6	4.3	C[C@H]1CC(NC(=O)CCc2nc(-c3ccc(F)cn3)no2)=C(C(=O)O)C[C@H]1c1cc(F)cc(F)c1F	10.1016/j.bmcl.2010.04.001
		CHEMBL1084799	7017	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	504	7	2	6	4.3	C[C@H]1CC(NC(=O)CCc2nc(-c3ccc(F)cn3)no2)=C(C(=O)O)C[C@H]1c1cc(F)cc(F)c1F	10.1016/j.bmcl.2010.04.001
		46890270	7375	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	395	8	3	3	4.9	CCCCC1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
		CHEMBL1086354	7375	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	395	8	3	3	4.9	CCCCC1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
		135800194	89491	0	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	354	6	3	7	2.1	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		CHEMBL237248	89491	0	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptorDisplacement of [3H]nicotinic acid from human GPR109A receptor	ChEMBL	354	6	3	7	2.1	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.11.116
		11736428	189063	0	None	-	0	Mouse	7.2	pIC50	=	7.2	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	232	4	2	4	1.5	CCCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL509541	189063	0	None	-	0	Mouse	7.2	pIC50	=	7.2	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	232	4	2	4	1.5	CCCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		12003791	194829	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
		CHEMBL1237147	194829	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
		CHEMBL539398	194829	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
		135899154	16209	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	315	5	1	4	2.7	O=c1[nH]c(COCCc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1224218	16209	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	315	5	1	4	2.7	O=c1[nH]c(COCCc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		12002524	191782	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)cc1F	10.1016/j.bmcl.2009.03.014
		CHEMBL519811	191782	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1ccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)cc1F	10.1016/j.bmcl.2009.03.014
		136375437	178081	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	432	8	3	7	3.6	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1cn(Cc2ccccc2)cc1C(=O)O	10.1016/j.bmcl.2020.127105
		CHEMBL4647670	178081	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	432	8	3	7	3.6	O=C(CCc1nc(-c2ccc(O)cc2)no1)Nc1cn(Cc2ccccc2)cc1C(=O)O	10.1016/j.bmcl.2020.127105
		135899325	16193	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	299	5	1	4	2.2	O=c1[nH]c(COCCc2ccc(F)cc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1224147	16193	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	299	5	1	4	2.2	O=c1[nH]c(COCCc2ccc(F)cc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		135899324	16191	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	327	7	1	6	2.2	COc1ccc(OCCCOc2nc3ncccc3c(=O)[nH]2)cc1	10.1016/j.bmcl.2010.07.108
		CHEMBL1224145	16191	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	327	7	1	6	2.2	COc1ccc(OCCCOc2nc3ncccc3c(=O)[nH]2)cc1	10.1016/j.bmcl.2010.07.108
		135899178	16210	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of radioligand from rat GPR109ADisplacement of radioligand from rat GPR109A	ChEMBL	315	5	1	4	2.7	O=c1[nH]c(COCCc2cccc(Cl)c2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1224219	16210	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of radioligand from rat GPR109ADisplacement of radioligand from rat GPR109A	ChEMBL	315	5	1	4	2.7	O=c1[nH]c(COCCc2cccc(Cl)c2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		156010038	177030	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Agonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysisAgonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysis	ChEMBL	414	8	3	4	5.1	CCCCn1cc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		CHEMBL4632359	177030	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Agonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysisAgonist activity at GPR109A receptor in human adipocytes assessed as inhibition of lipolysis	ChEMBL	414	8	3	4	5.1	CCCCn1cc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		16048768	94450	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	405	3	2	5	3.5	C[C@H]1CN(C(=O)Nc2ccccc2C(=O)O)[C@H](C)CN1c1cnc2ccccc2n1	10.1016/j.bmcl.2007.10.055
		CHEMBL251222	94450	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	405	3	2	5	3.5	C[C@H]1CN(C(=O)Nc2ccccc2C(=O)O)[C@H](C)CN1c1cnc2ccccc2n1	10.1016/j.bmcl.2007.10.055
		137659759	159267	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	314	4	3	4	1.9	O=C(CCC#Cc1ccc(O)cn1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4099278	159267	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	314	4	3	4	1.9	O=C(CCC#Cc1ccc(O)cn1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		12003787	195842	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	296	2	2	2	2.8	O=C(O)c1n[nH]c2c1CC(c1cc(F)cc(F)c1F)CC2	10.1016/j.bmcl.2009.06.054
		CHEMBL558463	195842	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	296	2	2	2	2.8	O=C(O)c1n[nH]c2c1CC(c1cc(F)cc(F)c1F)CC2	10.1016/j.bmcl.2009.06.054
		137639493	156911	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	315	4	2	2	3.0	O=C(CCC#Cc1ccccc1F)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4072283	156911	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	315	4	2	2	3.0	O=C(CCC#Cc1ccccc1F)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		135899321	16115	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	281	5	1	4	2.1	O=c1[nH]c(COCCc2ccccc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1223878	16115	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	281	5	1	4	2.1	O=c1[nH]c(COCCc2ccccc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		16048843	154391	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	392	3	3	6	2.3	Nc1ccc2nc(N3CCN(C(=O)Nc4ccccc4C(=O)O)CC3)cnc2c1	10.1016/j.bmcl.2007.10.055
		CHEMBL398762	154391	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	392	3	3	6	2.3	Nc1ccc2nc(N3CCN(C(=O)Nc4ccccc4C(=O)O)CC3)cnc2c1	10.1016/j.bmcl.2007.10.055
		11424509	188288	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	218	3	2	4	1.1	CCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL500239	188288	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	218	3	2	4	1.1	CCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		46890237	7099	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	370	6	3	6	2.2	Cc1c(CCC(=O)NC2=C(C(=O)O)CCCC2)cnn1-c1ccc(O)cn1	10.1016/j.bmcl.2010.04.013
		CHEMBL1085148	7099	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	370	6	3	6	2.2	Cc1c(CCC(=O)NC2=C(C(=O)O)CCCC2)cnn1-c1ccc(O)cn1	10.1016/j.bmcl.2010.04.013
		135966934	6842	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	452	7	3	7	3.3	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CC(c2cccc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1084030	6842	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	452	7	3	7	3.3	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CC(c2cccc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
		46890298	7162	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	433	6	3	3	5.0	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2cccc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1085414	7162	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	433	6	3	3	5.0	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2cccc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
		12002518	188879	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1cc(F)cc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		CHEMBL507182	188879	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1cc(F)cc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		12002518	188879	0	None	-	0	Mouse	7.2	pIC50	=	7.2	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1cc(F)cc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		CHEMBL507182	188879	0	None	-	0	Mouse	7.2	pIC50	=	7.2	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1cc(F)cc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		12002618	191991	0	None	-	0	Mouse	7.2	pIC50	=	7.2	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	306	2	2	4	1.9	Fc1cc(F)c(F)c(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		CHEMBL520137	191991	0	None	-	0	Mouse	7.2	pIC50	=	7.2	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	306	2	2	4	1.9	Fc1cc(F)c(F)c(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		12002618	191991	0	None	-	0	Mouse	7.2	pIC50	=	7.2	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	306	2	2	4	1.9	Fc1cc(F)c(F)c(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2010.06.041
		CHEMBL520137	191991	0	None	-	0	Mouse	7.2	pIC50	=	7.2	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	306	2	2	4	1.9	Fc1cc(F)c(F)c(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2010.06.041
		156020512	178104	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	403	9	3	8	2.3	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1cn(CCCF)cc1C(=O)O	10.1016/j.bmcl.2020.127105
		CHEMBL4647933	178104	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	403	9	3	8	2.3	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1cn(CCCF)cc1C(=O)O	10.1016/j.bmcl.2020.127105
		11624691	7227	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	361	6	3	3	4.3	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		CHEMBL1085711	7227	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	361	6	3	3	4.3	O=C(CCc1ccc(-c2ccc(O)cc2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		137641317	157011	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	383	6	2	2	5.0	O=C(CCc1ccc(-c2ccccc2Cl)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4073374	157011	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	383	6	2	2	5.0	O=C(CCc1ccc(-c2ccccc2Cl)cc1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		137648386	157772	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	347	4	3	3	3.2	O=C(CCC#Cc1ccc(O)cc1Cl)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4082765	157772	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	347	4	3	3	3.2	O=C(CCC#Cc1ccc(O)cc1Cl)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		12002616	184181	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1ccc(F)c(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		CHEMBL483142	184181	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1ccc(F)c(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		16048995	94655	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	375	3	2	3	3.9	O=C(O)c1ccccc1NC(=O)N1CCN(c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2007.10.055
		CHEMBL252505	94655	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	375	3	2	3	3.9	O=C(O)c1ccccc1NC(=O)N1CCN(c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2007.10.055
		11646494	121809	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	375	7	2	3	4.6	COc1cccc(-c2ccc(CCC(=O)Nc3ccccc3C(=O)O)cc2)c1	10.1016/j.bmc.2015.02.018
		CHEMBL3589783	121809	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	375	7	2	3	4.6	COc1cccc(-c2ccc(CCC(=O)Nc3ccccc3C(=O)O)cc2)c1	10.1016/j.bmc.2015.02.018
		11516424	7315	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	379	6	3	5	3.4	Cc1c(CC(C)C(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cc1	10.1016/j.bmcl.2010.04.013
		CHEMBL1086104	7315	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	379	6	3	5	3.4	Cc1c(CC(C)C(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cc1	10.1016/j.bmcl.2010.04.013
		12002521	184821	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	266	2	2	4	1.8	Cc1ccccc1C1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL485194	184821	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	266	2	2	4	1.8	Cc1ccccc1C1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		135401975	94748	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	393	3	3	6	2.4	O=C(O)c1ccccc1NC(=O)N1CCN(c2cnc3ccc(O)cc3n2)CC1	10.1016/j.bmcl.2007.10.055
		CHEMBL253128	94748	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	393	3	3	6	2.4	O=C(O)c1ccccc1NC(=O)N1CCN(c2cnc3ccc(O)cc3n2)CC1	10.1016/j.bmcl.2007.10.055
		11647028	88682	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	401	6	3	4	5.0	O=C(CCc1ccc(-c2ccc(O)cc2Cl)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		CHEMBL235954	88682	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	401	6	3	4	5.0	O=C(CCc1ccc(-c2ccc(O)cc2Cl)s1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		11501698	192570	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	376	5	3	6	2.9	O=C(CCc1nnn2c1ccc1cc(O)ccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
		CHEMBL521326	192570	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human GPR109A expressed in CHO cellsDisplacement of [3H]niacin from human GPR109A expressed in CHO cells	ChEMBL	376	5	3	6	2.9	O=C(CCc1nnn2c1ccc1cc(O)ccc12)Nc1ccccc1C(=O)O	10.1021/jm900151e
		136086829	7338	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	466	7	3	7	3.6	C[C@H]1CC(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)=C(C(=O)O)C[C@H]1c1cccc(F)c1	10.1016/j.bmcl.2010.04.001
		CHEMBL1086225	7338	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	466	7	3	7	3.6	C[C@H]1CC(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)=C(C(=O)O)C[C@H]1c1cccc(F)c1	10.1016/j.bmcl.2010.04.001
		46890269	7374	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	381	7	3	3	4.5	CCCC1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
		CHEMBL1086353	7374	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	381	7	3	3	4.5	CCCC1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1	10.1016/j.bmcl.2010.04.001
		15986755	184118	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	339	5	3	3	3.5	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.001
		CHEMBL482698	184118	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	339	5	3	3	3.5	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CCCC1	10.1016/j.bmcl.2010.04.001
		46890299	7215	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	433	6	3	3	5.0	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccc(F)cc2)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1085655	7215	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	433	6	3	3	5.0	O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2ccc(F)cc2)CC1	10.1016/j.bmcl.2010.04.001
		11736428	189063	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	232	4	2	4	1.5	CCCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL509541	189063	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	232	4	2	4	1.5	CCCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		12002618	191991	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	306	2	2	4	1.9	Fc1cc(F)c(F)c(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		CHEMBL520137	191991	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	306	2	2	4	1.9	Fc1cc(F)c(F)c(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		12002618	191991	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	306	2	2	4	1.9	Fc1cc(F)c(F)c(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2010.06.041
		CHEMBL520137	191991	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	306	2	2	4	1.9	Fc1cc(F)c(F)c(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2010.06.041
		12002517	191882	0	None	-	0	Mouse	7.1	pIC50	=	7.1	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	270	2	2	4	1.6	Fc1cccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		CHEMBL519966	191882	0	None	-	0	Mouse	7.1	pIC50	=	7.1	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	270	2	2	4	1.6	Fc1cccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		12003597	14978	0	None	-	0	Mouse	7.1	pIC50	=	7.1	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	234	2	2	3	2.1	O=C(O)c1n[nH]c2c1CC(c1ccsc1)C2	10.1016/j.bmcl.2010.06.041
		CHEMBL1208925	14978	0	None	-	0	Mouse	7.1	pIC50	=	7.1	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	234	2	2	3	2.1	O=C(O)c1n[nH]c2c1CC(c1ccsc1)C2	10.1016/j.bmcl.2010.06.041
		11710202	121808	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	359	6	2	2	4.9	Cc1cccc(-c2ccc(CCC(=O)Nc3ccccc3C(=O)O)cc2)c1	10.1016/j.bmc.2015.02.018
		CHEMBL3589782	121808	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	359	6	2	2	4.9	Cc1cccc(-c2ccc(CCC(=O)Nc3ccccc3C(=O)O)cc2)c1	10.1016/j.bmc.2015.02.018
		16048840	94044	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	391	3	2	5	3.1	O=C(O)c1ccccc1NC(=O)N1CCCN(c2cnc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
		CHEMBL248851	94044	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	391	3	2	5	3.1	O=C(O)c1ccccc1NC(=O)N1CCCN(c2cnc3ccccc3n2)CC1	10.1016/j.bmcl.2007.10.055
		44591601	184311	0	None	-	0	Mouse	6.1	pIC50	=	6.1	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	260	6	2	4	2.3	CCCCCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL484172	184311	0	None	-	0	Mouse	6.1	pIC50	=	6.1	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	260	6	2	4	2.3	CCCCCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		122181103	121814	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	363	6	2	2	4.8	O=C(CCc1ccc(-c2ccccc2F)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		CHEMBL3589788	121814	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	363	6	2	2	4.8	O=C(CCc1ccc(-c2ccccc2F)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		135899300	16114	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	295	6	1	4	2.7	O=c1[nH]c(OCCCCc2ccccc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1223877	16114	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	295	6	1	4	2.7	O=c1[nH]c(OCCCCc2ccccc2)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		46890538	7039	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	469	7	3	7	2.7	NC(Cc1nc(-c2ccc(F)cn2)no1)C(=O)NC1=C(C(=O)O)CC(c2cccc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1084840	7039	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	469	7	3	7	2.7	NC(Cc1nc(-c2ccc(F)cn2)no1)C(=O)NC1=C(C(=O)O)CC(c2cccc(F)c2)CC1	10.1016/j.bmcl.2010.04.001
		12003791	194829	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
		CHEMBL1237147	194829	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
		CHEMBL539398	194829	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum	ChEMBL	261	2	2	3	1.9	O=C(O)c1n[nH]c2c1CC(c1cccnc1F)CC2	10.1016/j.bmcl.2009.06.054
		12002616	184181	0	None	-	0	Mouse	6.1	pIC50	=	6.1	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1ccc(F)c(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		CHEMBL483142	184181	0	None	-	0	Mouse	6.1	pIC50	=	6.1	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1ccc(F)c(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1	10.1016/j.bmcl.2009.03.014
		11581300	121816	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	361	6	3	3	4.3	O=C(CCc1ccc(-c2ccccc2O)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		CHEMBL3589790	121816	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	361	6	3	3	4.3	O=C(CCc1ccc(-c2ccccc2O)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		135899150	16174	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	311	6	1	5	2.5	Cc1cccc(OCCCOc2nc3ncccc3c(=O)[nH]2)c1	10.1016/j.bmcl.2010.07.108
		CHEMBL1224074	16174	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	311	6	1	5	2.5	Cc1cccc(OCCCOc2nc3ncccc3c(=O)[nH]2)c1	10.1016/j.bmcl.2010.07.108
		11501164	187178	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	349	6	2	3	4.1	COc1ccc2cc(CCC(=O)Nc3ccccc3C(=O)O)ccc2c1	10.1016/j.bmcl.2008.08.030
		CHEMBL492220	187178	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsDisplacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells	ChEMBL	349	6	2	3	4.1	COc1ccc2cc(CCC(=O)Nc3ccccc3C(=O)O)ccc2c1	10.1016/j.bmcl.2008.08.030
		135401974	154723	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	393	3	3	6	2.4	O=C(O)c1ccccc1NC(=O)N1CCN(c2cnc3cccc(O)c3n2)CC1	10.1016/j.bmcl.2007.10.055
		CHEMBL399859	154723	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	393	3	3	6	2.4	O=C(O)c1ccccc1NC(=O)N1CCN(c2cnc3cccc(O)c3n2)CC1	10.1016/j.bmcl.2007.10.055
		44591601	184311	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	260	6	2	4	2.3	CCCCCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		CHEMBL484172	184311	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptorDisplacement of [3H]nicotinic acid from human GPR109a receptor	ChEMBL	260	6	2	4	2.3	CCCCCCC1Cc2[nH]nc(-c3nnn[nH]3)c2C1	10.1016/j.bmcl.2009.03.014
		137653026	158707	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	329	3	2	2	3.3	O=C(/C=C/C#Cc1ccccc1Cl)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		CHEMBL4093294	158707	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting methodDisplacement of [5,6-3H]-nicotinic acid from recombinant human HCA2 receptor expressed in Flp-IN HEK cell membranes after 2 hrs by microbeta counting method	ChEMBL	329	3	2	2	3.3	O=C(/C=C/C#Cc1ccccc1Cl)NC1=C(C(=O)O)CCCC1	10.1016/j.bmc.2017.06.028
		46890275	6530	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	412	8	3	6	3.2	CCCC1CCC(C(=O)O)=C(NC(=O)C(C)Cc2ccn(-c3ccc(O)cn3)n2)C1	10.1016/j.bmcl.2010.04.013
		CHEMBL1082823	6530	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	412	8	3	6	3.2	CCCC1CCC(C(=O)O)=C(NC(=O)C(C)Cc2ccn(-c3ccc(O)cn3)n2)C1	10.1016/j.bmcl.2010.04.013
		11617480	88681	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	362	6	3	4	3.7	O=C(CCc1ccc(-c2ccc(O)cn2)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		CHEMBL235952	88681	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	362	6	3	4	3.7	O=C(CCc1ccc(-c2ccc(O)cn2)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		46890577	6672	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	490	7	2	6	4.0	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2F)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1083442	6672	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	490	7	2	6	4.0	O=C(CCc1nc(-c2ccc(F)cn2)no1)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2F)CC1	10.1016/j.bmcl.2010.04.001
		136086824	6843	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	453	7	3	8	2.7	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CC(c2ccc(F)nc2)CC1	10.1016/j.bmcl.2010.04.001
		CHEMBL1084031	6843	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsDisplacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells	ChEMBL	453	7	3	8	2.7	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CC(c2ccc(F)nc2)CC1	10.1016/j.bmcl.2010.04.001
		12003788	194941	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	278	2	2	2	2.7	O=C(O)c1n[nH]c2c1CC(c1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.06.054
		CHEMBL1237148	194941	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	278	2	2	2	2.7	O=C(O)c1n[nH]c2c1CC(c1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.06.054
		CHEMBL542000	194941	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumDisplacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum	ChEMBL	278	2	2	2	2.7	O=C(O)c1n[nH]c2c1CC(c1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.06.054
		12003597	14978	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	234	2	2	3	2.1	O=C(O)c1n[nH]c2c1CC(c1ccsc1)C2	10.1016/j.bmcl.2010.06.041
		CHEMBL1208925	14978	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]nicotinic acid from human GPR10a receptorDisplacement of [3H]nicotinic acid from human GPR10a receptor	ChEMBL	234	2	2	3	2.1	O=C(O)c1n[nH]c2c1CC(c1ccsc1)C2	10.1016/j.bmcl.2010.06.041
		12002525	192343	0	None	-	0	Mouse	7.1	pIC50	=	7.1	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1cccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1F	10.1016/j.bmcl.2009.03.014
		CHEMBL520676	192343	0	None	-	0	Mouse	7.1	pIC50	=	7.1	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	288	2	2	4	1.8	Fc1cccc(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)c1F	10.1016/j.bmcl.2009.03.014
		11299550	192007	0	None	-	0	Mouse	5.1	pIC50	=	5.1	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	244	2	2	4	1.5	C1CCC(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)C1	10.1016/j.bmcl.2009.03.014
		CHEMBL520159	192007	0	None	-	0	Mouse	5.1	pIC50	=	5.1	Binding	Displacement of [3H]nicotinic acid from mouse GPR109a receptorDisplacement of [3H]nicotinic acid from mouse GPR109a receptor	ChEMBL	244	2	2	4	1.5	C1CCC(C2Cc3[nH]nc(-c4nnn[nH]4)c3C2)C1	10.1016/j.bmcl.2009.03.014
		122181107	121819	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	379	6	3	3	4.5	O=C(CCc1ccc(-c2ccc(O)c(F)c2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		CHEMBL3589793	121819	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	379	6	3	3	4.5	O=C(CCc1ccc(-c2ccc(O)c(F)c2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		46890199	7158	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	380	6	3	6	2.8	Cc1c(CC(C)C(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cn1	10.1016/j.bmcl.2010.04.013
		CHEMBL1085401	7158	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]niacin from GRP109A receptorDisplacement of [3H]niacin from GRP109A receptor	ChEMBL	380	6	3	6	2.8	Cc1c(CC(C)C(=O)Nc2ccccc2C(=O)O)cnn1-c1ccc(O)cn1	10.1016/j.bmcl.2010.04.013
		135899280	16134	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	308	5	2	4	1.6	O=C(CCc1ccccc1)NCc1nc2ncccc2c(=O)[nH]1	10.1016/j.bmcl.2010.07.108
		CHEMBL1223958	16134	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of radioligand from human GPR109ADisplacement of radioligand from human GPR109A	ChEMBL	308	5	2	4	1.6	O=C(CCc1ccccc1)NCc1nc2ncccc2c(=O)[nH]1	10.1016/j.bmcl.2010.07.108
		11625092	6684	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	379	6	2	2	5.3	O=C(CCc1ccc(-c2ccccc2Cl)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		CHEMBL1083473	6684	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	379	6	2	2	5.3	O=C(CCc1ccc(-c2ccccc2Cl)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		11617151	88639	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	345	6	2	2	4.6	O=C(CCc1ccc(-c2ccccc2)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		CHEMBL235741	88639	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]niacin from human GPR109ADisplacement of [3H]niacin from human GPR109A	ChEMBL	345	6	2	2	4.6	O=C(CCc1ccc(-c2ccccc2)cc1)Nc1ccccc1C(=O)O	10.1021/jm700942d
		11631886	121812	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	361	6	3	3	4.3	O=C(CCc1ccc(-c2cccc(O)c2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		CHEMBL3589786	121812	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysisDisplacement of [3H]-nicotinic acid from N-flag-tagged human HCA2 receptor expressed in HEK293T cell membranes by scintillation counting analysis	ChEMBL	361	6	3	3	4.3	O=C(CCc1ccc(-c2cccc(O)c2)cc1)Nc1ccccc1C(=O)O	10.1016/j.bmc.2015.02.018
		136375465	177133	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	357	6	3	8	1.4	Cn1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		CHEMBL4633857	177133	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysisDisplacement of [3H]nicotinic acid from GRP109A receptor (unknown origin) expressed in 293-EBNA cell membranes by liquid scintillation analysis	ChEMBL	357	6	3	8	1.4	Cn1cc(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)c(C(=O)O)c1	10.1016/j.bmcl.2020.127105
		49862073	14973	1	None	-	0	Mouse	6.0	pIC50	=	6	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	194	2	2	2	1.5	CC(C)C1Cc2[nH]nc(C(=O)O)c2C1	10.1016/j.bmcl.2010.06.041
		CHEMBL1208920	14973	1	None	-	0	Mouse	6.0	pIC50	=	6	Binding	Displacement of [3H]nicotinic acid from mouse GPR10a receptorDisplacement of [3H]nicotinic acid from mouse GPR10a receptor	ChEMBL	194	2	2	2	1.5	CC(C)C1Cc2[nH]nc(C(=O)O)c2C1	10.1016/j.bmcl.2010.06.041
		135887290	6987	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	430	6	3	7	2.6	O=C(O)C1=C(NC(=O)C(F)(F)C(F)(F)c2nc(-c3ccc(O)cn3)no2)CCCC1	10.1021/jm100022r
		CHEMBL1084657	6987	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	430	6	3	7	2.6	O=C(O)C1=C(NC(=O)C(F)(F)C(F)(F)c2nc(-c3ccc(O)cn3)no2)CCCC1	10.1021/jm100022r
		6436431	61701	4	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	158	4	1	3	0.6	CCCOC(=O)/C=C/C(=O)O	10.1016/j.bmcl.2010.11.091
		CHEMBL1771638	61701	4	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	158	4	1	3	0.6	CCCOC(=O)/C=C/C(=O)O	10.1016/j.bmcl.2010.11.091
		54580649	61747	2	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	220	5	1	3	1.4	O=C(O)/C=C/C(=O)OCCc1ccccc1	10.1016/j.bmcl.2010.11.091
		CHEMBL1771739	61747	2	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	220	5	1	3	1.4	O=C(O)/C=C/C(=O)OCCc1ccccc1	10.1016/j.bmcl.2010.11.091
		117629482	2823	140	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
		1588	2823	140	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
		1594	2823	140	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
		2835	2823	140	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
		938	2823	140	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
		CHEMBL573	2823	140	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
		DB00627	2823	140	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
		135887288	7616	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	398	6	3	7	2.6	O=C(O)C1=C(NC(=O)C2(Cc3nc(-c4ccc(O)cn4)no3)CCC2)CCCC1	10.1021/jm100022r
		CHEMBL1088074	7616	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	398	6	3	7	2.6	O=C(O)C1=C(NC(=O)C2(Cc3nc(-c4ccc(O)cn4)no3)CCC2)CCCC1	10.1021/jm100022r
		135887285	7438	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	384	6	3	7	2.2	O=C(O)C1=C(NC(=O)C2(Cc3nc(-c4ccc(O)cn4)no3)CC2)CCCC1	10.1021/jm100022r
		CHEMBL1086658	7438	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	384	6	3	7	2.2	O=C(O)C1=C(NC(=O)C2(Cc3nc(-c4ccc(O)cn4)no3)CC2)CCCC1	10.1021/jm100022r
		135416391	6920	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	372	6	3	7	2.4	CC(CC(=O)NC1=C(C(=O)O)CCCC1)c1nc(-c2ccc(O)cn2)no1	10.1021/jm100022r
		CHEMBL1084393	6920	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	372	6	3	7	2.4	CC(CC(=O)NC1=C(C(=O)O)CCCC1)c1nc(-c2ccc(O)cn2)no1	10.1021/jm100022r
		135800194	89491	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	354	6	3	7	2.1	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1ccccc1C(=O)O	10.1021/jm100022r
		CHEMBL237248	89491	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	354	6	3	7	2.1	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1ccccc1C(=O)O	10.1021/jm100022r
		11041813	93751	22	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	202	3	2	2	1.7	O=C(O)c1cc(Cc2ccccc2)n[nH]1	10.1021/jm030888c
		CHEMBL247317	93751	22	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	202	3	2	2	1.7	O=C(O)c1cc(Cc2ccccc2)n[nH]1	10.1021/jm030888c
		135887289	6921	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	386	6	3	7	2.5	CC(C)(CC(=O)NC1=C(C(=O)O)CCCC1)c1nc(-c2ccc(O)cn2)no1	10.1021/jm100022r
		CHEMBL1084394	6921	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	386	6	3	7	2.5	CC(C)(CC(=O)NC1=C(C(=O)O)CCCC1)c1nc(-c2ccc(O)cn2)no1	10.1021/jm100022r
		5787	3005	119	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	164	2	2	2	1.5	OC(=O)/C=C/c1ccc(cc1)O	10.1016/j.bmcl.2010.11.091
		637542	3005	119	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	164	2	2	2	1.5	OC(=O)/C=C/c1ccc(cc1)O	10.1016/j.bmcl.2010.11.091
		CHEMBL66879	3005	119	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	164	2	2	2	1.5	OC(=O)/C=C/c1ccc(cc1)O	10.1016/j.bmcl.2010.11.091
		DB04066	3005	119	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	164	2	2	2	1.5	OC(=O)/C=C/c1ccc(cc1)O	10.1016/j.bmcl.2010.11.091
		643403	101592	79	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	138	2	1	2	1.4	O=C(O)/C=C/c1ccoc1	10.1016/j.bmcl.2010.11.091
		CHEMBL298683	101592	79	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	138	2	1	2	1.4	O=C(O)/C=C/c1ccoc1	10.1016/j.bmcl.2010.11.091
		676464	89876	75	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	154	3	2	2	1.1	CCCc1cc(C(=O)O)n[nH]1	10.1021/jm030888c
		CHEMBL237788	89876	75	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	154	3	2	2	1.1	CCCc1cc(C(=O)O)n[nH]1	10.1021/jm030888c
		135416388	7524	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	358	6	3	7	1.8	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
		CHEMBL1087302	7524	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	358	6	3	7	1.8	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
		776416	18938	108	None	1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity at GPR109aBinding affinity at GPR109a	ChEMBL	152	1	2	2	0.6	O=C(O)c1n[nH]c2c1CCC2	10.1021/jm800896z
		CHEMBL128604	18938	108	None	1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity at GPR109aBinding affinity at GPR109a	ChEMBL	152	1	2	2	0.6	O=C(O)c1n[nH]c2c1CCC2	10.1021/jm800896z
		776416	18938	108	None	-1	2	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	152	1	2	2	0.6	O=C(O)c1n[nH]c2c1CCC2	10.1021/jm030888c
		CHEMBL128604	18938	108	None	-1	2	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	152	1	2	2	0.6	O=C(O)c1n[nH]c2c1CCC2	10.1021/jm030888c
		11830866	19409	35	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	216	4	2	2	1.9	O=C(O)c1cc(CCc2ccccc2)[nH]n1	10.1021/jm030888c
		CHEMBL129385	19409	35	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	216	4	2	2	1.9	O=C(O)c1cc(CCc2ccccc2)[nH]n1	10.1021/jm030888c
		5369209	2591	81	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	130	2	1	3	-0.2	COC(=O)/C=C/C(=O)O	10.1016/j.bmcl.2010.11.091
		5786	2591	81	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	130	2	1	3	-0.2	COC(=O)/C=C/C(=O)O	10.1016/j.bmcl.2010.11.091
		CHEMBL589586	2591	81	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	130	2	1	3	-0.2	COC(=O)/C=C/C(=O)O	10.1016/j.bmcl.2010.11.091
		DB14219	2591	81	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	130	2	1	3	-0.2	COC(=O)/C=C/C(=O)O	10.1016/j.bmcl.2010.11.091
		10878560	19147	3	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	216	3	2	2	2.0	Cc1ccc(Cc2cc(C(=O)O)[nH]n2)cc1	10.1021/jm030888c
		CHEMBL128949	19147	3	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	216	3	2	2	2.0	Cc1ccc(Cc2cc(C(=O)O)[nH]n2)cc1	10.1021/jm030888c
		13169286	18840	1	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	266	11	2	2	4.2	CCCCCCCCCCCc1cc(C(=O)O)[nH]n1	10.1021/jm030888c
		CHEMBL128077	18840	1	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	266	11	2	2	4.2	CCCCCCCCCCCc1cc(C(=O)O)[nH]n1	10.1021/jm030888c
		135416393	7629	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	374	6	4	8	0.8	O=C(O)C1=C(NC(=O)C(O)Cc2nc(-c3ccc(O)cn3)no2)CCCC1	10.1021/jm100022r
		CHEMBL1088213	7629	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	374	6	4	8	0.8	O=C(O)C1=C(NC(=O)C(O)Cc2nc(-c3ccc(O)cn3)no2)CCCC1	10.1021/jm100022r
		135416392	7437	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	372	6	3	7	2.0	CC(Cc1nc(-c2ccc(O)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
		CHEMBL1086656	7437	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	372	6	3	7	2.0	CC(Cc1nc(-c2ccc(O)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
		135416392	7437	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	372	6	3	7	2.0	CC(Cc1nc(-c2ccc(O)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
		CHEMBL1086656	7437	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	372	6	3	7	2.0	CC(Cc1nc(-c2ccc(O)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
		54582649	61750	1	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	224	4	1	3	1.5	O=C(O)/C=C/C(=O)OCc1cccc(F)c1	10.1016/j.bmcl.2010.11.091
		CHEMBL1771745	61750	1	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	224	4	1	3	1.5	O=C(O)/C=C/C(=O)OCc1cccc(F)c1	10.1016/j.bmcl.2010.11.091
		135887289	6921	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	386	6	3	7	2.5	CC(C)(CC(=O)NC1=C(C(=O)O)CCCC1)c1nc(-c2ccc(O)cn2)no1	10.1021/jm100022r
		CHEMBL1084394	6921	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	386	6	3	7	2.5	CC(C)(CC(=O)NC1=C(C(=O)O)CCCC1)c1nc(-c2ccc(O)cn2)no1	10.1021/jm100022r
		5816396	61705	6	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	200	7	1	3	1.8	CCCCCCOC(=O)/C=C/C(=O)O	10.1016/j.bmcl.2010.11.091
		CHEMBL1771642	61705	6	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	200	7	1	3	1.8	CCCCCCOC(=O)/C=C/C(=O)O	10.1016/j.bmcl.2010.11.091
		135416391	6920	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	372	6	3	7	2.4	CC(CC(=O)NC1=C(C(=O)O)CCCC1)c1nc(-c2ccc(O)cn2)no1	10.1021/jm100022r
		CHEMBL1084393	6920	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	372	6	3	7	2.4	CC(CC(=O)NC1=C(C(=O)O)CCCC1)c1nc(-c2ccc(O)cn2)no1	10.1021/jm100022r
		135416388	7524	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	358	6	3	7	1.8	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
		CHEMBL1087302	7524	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	358	6	3	7	1.8	O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
		117629482	2823	140	None	3	2	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm030888c
		1588	2823	140	None	3	2	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm030888c
		1594	2823	140	None	3	2	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm030888c
		2835	2823	140	None	3	2	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm030888c
		938	2823	140	None	3	2	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm030888c
		CHEMBL573	2823	140	None	3	2	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm030888c
		DB00627	2823	140	None	3	2	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm030888c
		648852	116910	91	None	1	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity at GPR109aBinding affinity at GPR109a	ChEMBL	166	1	2	2	1.0	O=C(O)c1n[nH]c2c1CCCC2	10.1021/jm800896z
		CHEMBL338405	116910	91	None	1	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity at GPR109aBinding affinity at GPR109a	ChEMBL	166	1	2	2	1.0	O=C(O)c1n[nH]c2c1CCCC2	10.1021/jm800896z
		6437229	61745	9	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	206	4	1	3	1.4	O=C(O)/C=C/C(=O)OCc1ccccc1	10.1016/j.bmcl.2010.11.091
		CHEMBL1771737	61745	9	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	206	4	1	3	1.4	O=C(O)/C=C/C(=O)OCc1ccccc1	10.1016/j.bmcl.2010.11.091
		648852	116910	91	None	-1	2	Rat	5.5	pKi	=	5.5	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	166	1	2	2	1.0	O=C(O)c1n[nH]c2c1CCCC2	10.1021/jm030888c
		CHEMBL338405	116910	91	None	-1	2	Rat	5.5	pKi	=	5.5	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	166	1	2	2	1.0	O=C(O)c1n[nH]c2c1CCCC2	10.1021/jm030888c
		135887288	7616	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	398	6	3	7	2.6	O=C(O)C1=C(NC(=O)C2(Cc3nc(-c4ccc(O)cn4)no3)CCC2)CCCC1	10.1021/jm100022r
		CHEMBL1088074	7616	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	398	6	3	7	2.6	O=C(O)C1=C(NC(=O)C2(Cc3nc(-c4ccc(O)cn4)no3)CCC2)CCCC1	10.1021/jm100022r
		10857469	118557	4	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	236	3	2	2	2.4	O=C(O)c1cc(Cc2ccc(Cl)cc2)[nH]n1	10.1021/jm030888c
		CHEMBL341520	118557	4	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	236	3	2	2	2.4	O=C(O)c1cc(Cc2ccc(Cl)cc2)[nH]n1	10.1021/jm030888c
		818267	118452	83	None	-	1	Rat	4.4	pKi	=	4.4	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	202	2	2	2	2.1	Cc1ccc(-c2cc(C(=O)O)[nH]n2)cc1	10.1021/jm030888c
		CHEMBL341154	118452	83	None	-	1	Rat	4.4	pKi	=	4.4	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	202	2	2	2	2.1	Cc1ccc(-c2cc(C(=O)O)[nH]n2)cc1	10.1021/jm030888c
		135416394	2560	52	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
		5788	2560	52	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
		73755154	2560	52	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
		CHEMBL1086657	2560	52	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
		135416392	7437	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	372	6	3	7	2.0	CC(Cc1nc(-c2ccc(O)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
		CHEMBL1086656	7437	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	372	6	3	7	2.0	CC(Cc1nc(-c2ccc(O)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
		135800194	89491	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	354	6	3	7	2.1	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1ccccc1C(=O)O	10.1021/jm100022r
		CHEMBL237248	89491	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	354	6	3	7	2.1	O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1ccccc1C(=O)O	10.1021/jm100022r
		5358902	61700	79	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	144	3	1	3	0.2	CCOC(=O)/C=C/C(=O)O	10.1016/j.bmcl.2010.11.091
		CHEMBL1771637	61700	79	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	144	3	1	3	0.2	CCOC(=O)/C=C/C(=O)O	10.1016/j.bmcl.2010.11.091
		6057891	61702	33	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	158	3	1	3	0.6	CC(C)OC(=O)/C=C/C(=O)O	10.1016/j.bmcl.2010.11.091
		CHEMBL1771639	61702	33	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	158	3	1	3	0.6	CC(C)OC(=O)/C=C/C(=O)O	10.1016/j.bmcl.2010.11.091
		3203	939	111	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	148	2	1	1	1.8	OC(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2010.11.091
		444539	939	111	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	148	2	1	1	1.8	OC(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2010.11.091
		CHEMBL27246	939	111	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	148	2	1	1	1.8	OC(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2010.11.091
		117629482	2823	140	None	-3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm800258p
		1588	2823	140	None	-3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm800258p
		1594	2823	140	None	-3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm800258p
		2835	2823	140	None	-3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm800258p
		938	2823	140	None	-3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm800258p
		CHEMBL573	2823	140	None	-3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm800258p
		DB00627	2823	140	None	-3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm800258p
		11776293	149257	8	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	236	3	2	2	2.4	O=C(O)c1cc(Cc2cccc(Cl)c2)n[nH]1	10.1021/jm030888c
		CHEMBL394441	149257	8	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	236	3	2	2	2.4	O=C(O)c1cc(Cc2cccc(Cl)c2)n[nH]1	10.1021/jm030888c
		11159621	2548	46	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
		5784	2548	46	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
		CHEMBL456145	2548	46	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
		DB05939	2548	46	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	ChEMBL	176	1	2	4	0.1	n1[nH]nc(n1)c1n[nH]c2c1CCC2	10.1021/jm800258p
		735981	61752	101	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	154	2	1	2	1.8	O=C(O)/C=C/c1cccs1	10.1016/j.bmcl.2010.11.091
		CHEMBL1771765	61752	101	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	154	2	1	2	1.8	O=C(O)/C=C/c1cccs1	10.1016/j.bmcl.2010.11.091
		14112183	61746	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	220	4	1	3	1.9	CC(OC(=O)/C=C/C(=O)O)c1ccccc1	10.1016/j.bmcl.2010.11.091
		CHEMBL1771738	61746	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	220	4	1	3	1.9	CC(OC(=O)/C=C/C(=O)O)c1ccccc1	10.1016/j.bmcl.2010.11.091
		574310	18956	148	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	112	1	2	2	0.1	O=C(O)c1cc[nH]n1	10.1021/jm030888c
		CHEMBL128679	18956	148	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	112	1	2	2	0.1	O=C(O)c1cc[nH]n1	10.1021/jm030888c
		135416394	2560	52	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
		5788	2560	52	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
		73755154	2560	52	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
		CHEMBL1086657	2560	52	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	10.1021/jm100022r
		11746440	19403	1	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	230	5	2	2	2.3	O=C(O)c1cc(CCCc2ccccc2)[nH]n1	10.1021/jm030888c
		CHEMBL129326	19403	1	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	230	5	2	2	2.3	O=C(O)c1cc(CCCc2ccccc2)[nH]n1	10.1021/jm030888c
		4430637	116837	93	None	-	1	Rat	4.2	pKi	=	4.2	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	222	2	2	2	2.4	O=C(O)c1cc(-c2cccc(Cl)c2)[nH]n1	10.1021/jm030888c
		CHEMBL338017	116837	93	None	-	1	Rat	4.2	pKi	=	4.2	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	222	2	2	2	2.4	O=C(O)c1cc(-c2cccc(Cl)c2)[nH]n1	10.1021/jm030888c
		135416393	7629	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	374	6	4	8	0.8	O=C(O)C1=C(NC(=O)C(O)Cc2nc(-c3ccc(O)cn3)no2)CCCC1	10.1021/jm100022r
		CHEMBL1088213	7629	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	374	6	4	8	0.8	O=C(O)C1=C(NC(=O)C(O)Cc2nc(-c3ccc(O)cn3)no2)CCCC1	10.1021/jm100022r
		10922388	18516	3	None	-	1	Rat	4.2	pKi	=	4.2	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	232	4	2	3	1.7	COc1ccc(Cc2cc(C(=O)O)[nH]n2)cc1	10.1021/jm030888c
		CHEMBL127387	18516	3	None	-	1	Rat	4.2	pKi	=	4.2	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	232	4	2	3	1.7	COc1ccc(Cc2cc(C(=O)O)[nH]n2)cc1	10.1021/jm030888c
		776421	89928	108	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	154	2	2	2	1.2	CC(C)c1cc(C(=O)O)n[nH]1	10.1021/jm030888c
		CHEMBL238002	89928	108	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	154	2	2	2	1.2	CC(C)c1cc(C(=O)O)n[nH]1	10.1021/jm030888c
		10103897	61704	3	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	186	6	1	3	1.4	CCCCCOC(=O)/C=C/C(=O)O	10.1016/j.bmcl.2010.11.091
		CHEMBL1771641	61704	3	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	186	6	1	3	1.4	CCCCCOC(=O)/C=C/C(=O)O	10.1016/j.bmcl.2010.11.091
		13153555	93863	27	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity at GPR109aBinding affinity at GPR109a	ChEMBL	182	5	2	2	1.8	CCCCCc1cc(C(=O)O)[nH]n1	10.1021/jm800896z
		CHEMBL247921	93863	27	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity at GPR109aBinding affinity at GPR109a	ChEMBL	182	5	2	2	1.8	CCCCCc1cc(C(=O)O)[nH]n1	10.1021/jm800896z
		1591	131	63	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1021/jm030888c
		6485181	131	63	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1021/jm030888c
		CHEMBL428730	131	63	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1021/jm030888c
		5475335	61703	28	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	172	5	1	3	1.0	CCCCOC(=O)/C=C/C(=O)O	10.1016/j.bmcl.2010.11.091
		CHEMBL1771640	61703	28	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	172	5	1	3	1.0	CCCCOC(=O)/C=C/C(=O)O	10.1016/j.bmcl.2010.11.091
		135416392	7437	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	372	6	3	7	2.0	CC(Cc1nc(-c2ccc(O)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
		CHEMBL1086656	7437	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	372	6	3	7	2.0	CC(Cc1nc(-c2ccc(O)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1	10.1021/jm100022r
		643402	61751	99	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	138	2	1	2	1.4	O=C(O)/C=C/c1ccco1	10.1016/j.bmcl.2010.11.091
		CHEMBL1771761	61751	99	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	138	2	1	2	1.4	O=C(O)/C=C/c1ccco1	10.1016/j.bmcl.2010.11.091
		117629482	2823	140	None	-3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
		1588	2823	140	None	-3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
		1594	2823	140	None	-3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
		2835	2823	140	None	-3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
		938	2823	140	None	-3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
		CHEMBL573	2823	140	None	-3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
		DB00627	2823	140	None	-3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1021/jm100022r
		135887290	6987	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	430	6	3	7	2.6	O=C(O)C1=C(NC(=O)C(F)(F)C(F)(F)c2nc(-c3ccc(O)cn3)no2)CCCC1	10.1021/jm100022r
		CHEMBL1084657	6987	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	430	6	3	7	2.6	O=C(O)C1=C(NC(=O)C(F)(F)C(F)(F)c2nc(-c3ccc(O)cn3)no2)CCCC1	10.1021/jm100022r
		54583606	61749	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	240	4	1	3	2.0	O=C(O)/C=C/C(=O)OCc1cccc(Cl)c1	10.1016/j.bmcl.2010.11.091
		CHEMBL1771744	61749	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	240	4	1	3	2.0	O=C(O)/C=C/C(=O)OCc1cccc(Cl)c1	10.1016/j.bmcl.2010.11.091
		135887285	7438	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	384	6	3	7	2.2	O=C(O)C1=C(NC(=O)C2(Cc3nc(-c4ccc(O)cn4)no3)CC2)CCCC1	10.1021/jm100022r
		CHEMBL1086658	7438	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminDisplacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin	ChEMBL	384	6	3	7	2.2	O=C(O)C1=C(NC(=O)C2(Cc3nc(-c4ccc(O)cn4)no3)CC2)CCCC1	10.1021/jm100022r
		54582648	61748	1	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	284	4	1	3	2.1	O=C(O)/C=C/C(=O)OCc1cccc(Br)c1	10.1016/j.bmcl.2010.11.091
		CHEMBL1771743	61748	1	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	ChEMBL	284	4	1	3	2.1	O=C(O)/C=C/C(=O)OCc1cccc(Br)c1	10.1016/j.bmcl.2010.11.091
		117629482	2823	140	None	-	2	Mouse	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from mouse GPR109ADisplacement of [3H]niacin from mouse GPR109A	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		1588	2823	140	None	-	2	Mouse	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from mouse GPR109ADisplacement of [3H]niacin from mouse GPR109A	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		1594	2823	140	None	-	2	Mouse	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from mouse GPR109ADisplacement of [3H]niacin from mouse GPR109A	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		2835	2823	140	None	-	2	Mouse	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from mouse GPR109ADisplacement of [3H]niacin from mouse GPR109A	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		938	2823	140	None	-	2	Mouse	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from mouse GPR109ADisplacement of [3H]niacin from mouse GPR109A	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		CHEMBL573	2823	140	None	-	2	Mouse	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from mouse GPR109ADisplacement of [3H]niacin from mouse GPR109A	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		DB00627	2823	140	None	-	2	Mouse	8.2	pIC50	=	8.2	Binding	Displacement of [3H]niacin from mouse GPR109ADisplacement of [3H]niacin from mouse GPR109A	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		117629482	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
		117629482	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12563315
		117629482	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12646212
		1588	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
		1588	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12563315
		1588	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12646212
		1594	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
		1594	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12563315
		1594	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12646212
		2835	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
		2835	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12563315
		2835	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12646212
		938	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
		938	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12563315
		938	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12646212
		CHEMBL573	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
		CHEMBL573	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12563315
		CHEMBL573	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12646212
		DB00627	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
		DB00627	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12563315
		DB00627	2823	140	None	-3	2	Human	7.2	pKd	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12646212
		637568	217740	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	Drug Central	144	2	0	4	-0.1	COC(=O)\C=C\C(=O)OC	None
		117629482	2823	140	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		1588	2823	140	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		1594	2823	140	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		2835	2823	140	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		938	2823	140	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		CHEMBL573	2823	140	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		DB00627	2823	140	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsDisplacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		117629482	2823	140	None	3	2	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		1588	2823	140	None	3	2	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		1594	2823	140	None	3	2	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		2835	2823	140	None	3	2	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		938	2823	140	None	3	2	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		CHEMBL573	2823	140	None	3	2	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		DB00627	2823	140	None	3	2	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
		5369209	2591	81	None	-	1	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	130	2	1	3	-0.2	COC(=O)/C=C/C(=O)O	21167710
		5786	2591	81	None	-	1	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	130	2	1	3	-0.2	COC(=O)/C=C/C(=O)O	21167710
		CHEMBL589586	2591	81	None	-	1	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	130	2	1	3	-0.2	COC(=O)/C=C/C(=O)O	21167710
		DB14219	2591	81	None	-	1	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	130	2	1	3	-0.2	COC(=O)/C=C/C(=O)O	21167710
		135416394	2560	52	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	20184326
		5788	2560	52	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	20184326
		73755154	2560	52	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	20184326
		CHEMBL1086657	2560	52	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	3	7	2.4	Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C	20184326
		1591	131	63	None	-	1	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	12930155
		6485181	131	63	None	-	1	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	12930155
		CHEMBL428730	131	63	None	-	1	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	12930155

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Ligand source activities (1 row/activity)