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Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	11715531	88697	21	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	5	2	4	1.9	C=CCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL236013	88697	21	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	5	2	4	1.9	C=CCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	28400380	89917	4	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	5	2	3	2.0	CCCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237945	89917	4	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	5	2	3	2.0	CCCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11415838	136357	0	None	-1	2	Human	5.0	pEC50	=	5.0	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	316	2	1	4	2.6	Cc1sc(C2(C)OC(C(=O)O)=CC2=O)cc1Br	10.1021/jm070022x
	CHEMBL373484	136357	0	None	-1	2	Human	5.0	pEC50	=	5.0	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	316	2	1	4	2.6	Cc1sc(C2(C)OC(C(=O)O)=CC2=O)cc1Br	10.1021/jm070022x
	28400046	89810	3	None	32	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	1.8	CC(C)CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237737	89810	3	None	32	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	1.8	CC(C)CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	10198518	73537	30	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	231	2	1	4	2.2	O=C(O)c1ccc2c(c1)nnn2C1CCCC1	10.1021/jm051099t
	CHEMBL201724	73537	30	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	231	2	1	4	2.2	O=C(O)c1ccc2c(c1)nnn2C1CCCC1	10.1021/jm051099t
	24955646	58034	0	None	-186	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	310	5	1	4	2.9	CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	CHEMBL1672639	58034	0	None	-186	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	310	5	1	4	2.9	CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	1591	131	63	None	-33	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.07.101
	6485181	131	63	None	-33	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.07.101
	CHEMBL428730	131	63	None	-33	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.07.101
	28400196	90252	19	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	266	7	1	4	2.9	CCCN(CCC)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL238376	90252	19	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	266	7	1	4	2.9	CCCN(CCC)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	44433532	152409	0	None	-16	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	2	2	4	0.3	CCc1[nH]nc(-c2nnn[nH]2)c1F	10.1016/j.bmcl.2007.07.101
	CHEMBL397055	152409	0	None	-16	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	2	2	4	0.3	CCc1[nH]nc(-c2nnn[nH]2)c1F	10.1016/j.bmcl.2007.07.101
	11219885	83462	0	None	-3	2	Human	4.9	pEC50	=	4.9	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	286	2	1	3	2.5	CC1(c2cccc(C(F)(F)F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL220001	83462	0	None	-3	2	Human	4.9	pEC50	=	4.9	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	286	2	1	3	2.5	CC1(c2cccc(C(F)(F)F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	15604642	75254	0	None	-323	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	250	3	2	4	0.8	CC(C)CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036948	75254	0	None	-323	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	250	3	2	4	0.8	CC(C)CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	43131474	151641	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	4	2	3	2.2	CC(C)C(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL396382	151641	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	4	2	3	2.2	CC(C)C(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11961288	196710	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	313	6	2	4	3.4	O=C(O)c1cc(N(Cc2ccccc2)Cc2ccsc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL564914	196710	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	313	6	2	4	3.4	O=C(O)c1cc(N(Cc2ccccc2)Cc2ccsc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	15604637	75260	0	None	-70	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	262	4	2	4	0.9	O=c1[nH]c(=O)c2c(CCCC3CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036955	75260	0	None	-70	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	262	4	2	4	0.9	O=c1[nH]c(=O)c2c(CCCC3CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	11380943	83459	1	None	-20	2	Human	4.9	pEC50	=	4.9	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL219980	83459	1	None	-20	2	Human	4.9	pEC50	=	4.9	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	45269912	195910	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	O=C(O)c1cc(N(Cc2ccsc2)Cc2cccs2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL559204	195910	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	O=C(O)c1cc(N(Cc2ccsc2)Cc2cccs2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11687485	90049	4	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	254	6	2	5	1.7	COCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL238164	90049	4	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	254	6	2	5	1.7	COCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11483496	126	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm800896z
	1589	126	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm800896z
	CHEMBL375493	126	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm800896z
	11483496	126	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1589	126	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL375493	126	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	28400406	89918	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	6	2	3	2.4	CCCCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237946	89918	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	6	2	3	2.4	CCCCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11528819	145506	23	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	2	4	2.5	CCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL391473	145506	23	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	2	4	2.5	CCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	2829816	88747	54	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	6	2	4	2.5	CCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL236219	88747	54	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	6	2	4	2.5	CCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	17965902	89814	4	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	242	3	2	3	2.0	O=C(O)c1ccc(NC(=O)c2ccccc2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL237739	89814	4	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	242	3	2	3	2.0	O=C(O)c1ccc(NC(=O)c2ccccc2)nc1	10.1016/j.bmcl.2007.09.058
	11379903	84271	0	None	-6	2	Human	4.8	pEC50	=	4.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL221282	84271	0	None	-6	2	Human	4.8	pEC50	=	4.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	43271548	90256	4	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	1	3	1.6	CCCN(C)c1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL238387	90256	4	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	1	3	1.6	CCCN(C)c1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11379903	84271	0	None	-6	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL221282	84271	0	None	-6	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	11379903	84271	0	None	-6	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm800896z
	CHEMBL221282	84271	0	None	-6	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm800896z
	11436345	143	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1599	143	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL424938	143	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	11218626	84892	0	None	1	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1csc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	CHEMBL223623	84892	0	None	1	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1csc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	13153555	93863	27	None	-42	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	5	2	2	1.8	CCCCCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.07.101
	CHEMBL247921	93863	27	None	-42	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	5	2	2	1.8	CCCCCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.07.101
	15605571	75235	2	None	-23	5	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	236	3	2	4	0.5	CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036813	75235	2	None	-23	5	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	236	3	2	4	0.5	CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	11470798	137967	1	None	-2	2	Human	4.7	pEC50	=	4.7	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)c(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL376419	137967	1	None	-2	2	Human	4.7	pEC50	=	4.7	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)c(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	283475	89805	118	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	196	3	2	4	1.3	CNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL237731	89805	118	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	196	3	2	4	1.3	CNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11528793	88702	4	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	236	4	2	4	2.3	O=C(O)c1ccc(NC2CCC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL236028	88702	4	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	236	4	2	4	2.3	O=C(O)c1ccc(NC2CCC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	10263467	140894	2	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	235	4	1	5	1.3	COCC(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL382096	140894	2	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	235	4	1	5	1.3	COCC(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	2776549	73391	82	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	177	1	1	4	0.7	Cn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL201513	73391	82	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	177	1	1	4	0.7	Cn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	3684804	90250	48	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	3	1	4	1.4	CN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL238374	90250	48	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	3	1	4	1.4	CN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11322738	136766	1	None	-13	2	Human	4.7	pEC50	=	4.7	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	252	2	1	3	2.1	CC1(c2cccc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL374111	136766	1	None	-13	2	Human	4.7	pEC50	=	4.7	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	252	2	1	3	2.1	CC1(c2cccc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	3729086	145597	58	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	4	2	4	1.7	CCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL391547	145597	58	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	4	2	4	1.7	CCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	10465474	140457	27	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	203	2	1	4	1.5	O=C(O)c1ccc2c(c1)nnn2C1CC1	10.1021/jm051099t
	CHEMBL380939	140457	27	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	203	2	1	4	1.5	O=C(O)c1ccc2c(c1)nnn2C1CC1	10.1021/jm051099t
	11322761	141606	1	None	-1	2	Human	4.6	pEC50	=	4.6	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)cc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL385103	141606	1	None	-1	2	Human	4.6	pEC50	=	4.6	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)cc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	3824366	89508	57	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	258	4	2	4	3.0	O=C(O)c1ccc(Nc2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	3953363	89508	57	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	258	4	2	4	3.0	O=C(O)c1ccc(Nc2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL237296	89508	57	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	258	4	2	4	3.0	O=C(O)c1ccc(Nc2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	45269046	196387	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	O=C(O)c1cc(N(Cc2cccs2)Cc2cccs2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL562675	196387	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	O=C(O)c1cc(N(Cc2cccs2)Cc2cccs2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11708383	88519	36	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	4	2	4	2.1	CC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL235144	88519	36	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	4	2	4	2.1	CC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	10421571	74225	2	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	235	5	1	5	1.2	CCOCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202351	74225	2	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	235	5	1	5	1.2	CCOCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	10398515	135291	33	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	1	1	4	1.9	CC(C)(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL372727	135291	33	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	1	1	4	1.9	CC(C)(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	28400056	152223	1	None	74	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	5	2	3	2.4	CCC(CC)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL396879	152223	1	None	74	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	5	2	3	2.4	CCC(CC)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11276453	84876	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1ccc(C2(C)OC(C(=O)O)=CC2=O)s1	10.1021/jm070022x
	CHEMBL223566	84876	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1ccc(C2(C)OC(C(=O)O)=CC2=O)s1	10.1021/jm070022x
	11492560	88518	5	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	7	2	4	2.9	CCCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL235141	88518	5	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	7	2	4	2.9	CCCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	10014206	73040	3	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	233	5	1	4	2.3	CCCCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL201048	73040	3	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	233	5	1	4	2.3	CCCCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	11715556	120	40	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	10.1016/j.bmcl.2007.09.058
	5801	120	40	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	10.1016/j.bmcl.2007.09.058
	CHEMBL236011	120	40	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	10.1016/j.bmcl.2007.09.058
	44250176	1131	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	10.1016/j.bmcl.2009.05.108
	5800	1131	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	10.1016/j.bmcl.2009.05.108
	CHEMBL564300	1131	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	10.1016/j.bmcl.2009.05.108
	51346919	57843	6	None	-100	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	296	5	1	4	2.5	O=c1cc(CCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1671877	57843	6	None	-100	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	296	5	1	4	2.5	O=c1cc(CCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	1595	259	49	None	-4	2	Human	5.5	pEC50	=	5.5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	51576	259	49	None	-4	2	Human	5.5	pEC50	=	5.5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	CHEMBL278488	259	49	None	-4	2	Human	5.5	pEC50	=	5.5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	10353934	133161	2	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	233	4	1	4	2.5	CCC(CC)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL370386	133161	2	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	233	4	1	4	2.5	CCC(CC)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	10422270	73372	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	251	5	1	5	1.9	CCSCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL201409	73372	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	251	5	1	5	1.9	CCSCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	4992776	90240	33	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	4	2	4	1.9	O=C(O)c1ccc(NC2CC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL238358	90240	33	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	4	2	4	1.9	O=C(O)c1ccc(NC2CC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	11565047	147218	25	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	250	4	2	4	2.6	O=C(O)c1ccc(NC2CCCC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL392830	147218	25	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	250	4	2	4	2.6	O=C(O)c1ccc(NC2CCCC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	2942936	149864	19	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	266	5	2	5	1.9	O=C(O)c1ccc(NCC2CCCO2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL394906	149864	19	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	266	5	2	5	1.9	O=C(O)c1ccc(NCC2CCCO2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	44434363	168971	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	286	4	2	4	2.5	O=C(O)c1ccc(NC(=O)c2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL439028	168971	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	286	4	2	4	2.5	O=C(O)c1ccc(NC(=O)c2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	10330955	169105	3	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	217	2	1	4	1.9	O=C(O)c1ccc2c(c1)nnn2C1CCC1	10.1021/jm051099t
	CHEMBL440041	169105	3	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	217	2	1	4	1.9	O=C(O)c1ccc2c(c1)nnn2C1CCC1	10.1021/jm051099t
	10398583	73969	13	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	221	4	1	5	0.8	COCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202157	73969	13	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	221	4	1	5	0.8	COCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	28400038	88609	36	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	178	3	2	3	1.4	O=C(O)c1ccc(NC2CC2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL235615	88609	36	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	178	3	2	3	1.4	O=C(O)c1ccc(NC2CC2)nc1	10.1016/j.bmcl.2007.09.058
	44433529	88536	0	None	5	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	CHEMBL235230	88536	0	None	5	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	2771812	89811	53	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	214	3	2	3	2.5	O=C(O)c1ccc(Nc2ccccc2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL237738	89811	53	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	214	3	2	3	2.5	O=C(O)c1ccc(Nc2ccccc2)nc1	10.1016/j.bmcl.2007.09.058
	43187344	90254	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	5	2	4	1.2	COCC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL238385	90254	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	5	2	4	1.2	COCC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11817645	84906	1	None	-12	2	Human	4.5	pEC50	=	4.5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2cc(F)cc(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL223700	84906	1	None	-12	2	Human	4.5	pEC50	=	4.5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2cc(F)cc(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	10013684	74029	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	3	1	4	2.1	CCC(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202206	74029	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	3	1	4	2.1	CCC(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	4712703	141222	44	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	204	2	1	3	2.3	CC(C)n1cnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL382863	141222	44	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	204	2	1	3	2.3	CC(C)n1cnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	44433529	88536	0	None	5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	CHEMBL235230	88536	0	None	5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	11322762	137602	1	None	-5	2	Human	4.4	pEC50	=	4.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2c(F)cccc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL375625	137602	1	None	-5	2	Human	4.4	pEC50	=	4.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2c(F)cccc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	43085192	89431	1	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	5	2	4	2.7	CC(C)C(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL237077	89431	1	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	5	2	4	2.7	CC(C)C(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11483496	126	0	None	-14	2	Human	6.4	pEC50	=	6.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1589	126	0	None	-14	2	Human	6.4	pEC50	=	6.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL375493	126	0	None	-14	2	Human	6.4	pEC50	=	6.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	11311474	165782	0	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2ccc(Cl)s2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL424750	165782	0	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2ccc(Cl)s2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	43187332	152220	2	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	2.0	CCC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL396878	152220	2	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	2.0	CCC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	1447952	89809	7	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	206	3	2	3	2.1	O=C(O)c1ccc(NC2CCCC2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL237735	89809	7	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	206	3	2	3	2.1	O=C(O)c1ccc(NC2CCCC2)nc1	10.1016/j.bmcl.2007.09.058
	11744994	89806	26	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	166	3	2	3	1.2	CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237732	89806	26	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	166	3	2	3	1.2	CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	1597	1965	80	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	10.1021/jm051099t
	2736690	1965	80	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	10.1021/jm051099t
	CHEMBL381638	1965	80	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	10.1021/jm051099t
	45268162	196239	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	235	6	2	3	1.7	O=C(O)c1cc(N(CC2CC2)CC2CC2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL561720	196239	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	235	6	2	3	1.7	O=C(O)c1cc(N(CC2CC2)CC2CC2)[nH]n1	10.1016/j.bmcl.2009.05.108
	28399894	149287	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	178	4	2	3	1.4	C=CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2009.05.108
	CHEMBL394468	149287	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	178	4	2	3	1.4	C=CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2009.05.108
	11324121	84666	0	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	CC1(c2cc(Br)cs2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL222472	84666	0	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	CC1(c2cc(Br)cs2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	776421	89928	108	None	-30	2	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	154	2	2	2	1.2	CC(C)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL238002	89928	108	None	-30	2	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	154	2	2	2	1.2	CC(C)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.07.101
	1595	259	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	51576	259	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	CHEMBL278488	259	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	1595	259	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	51576	259	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	CHEMBL278488	259	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	11183678	84772	1	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	224	2	1	4	1.5	CC1(c2ccsc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL223140	84772	1	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	224	2	1	4	1.5	CC1(c2ccsc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	1595	259	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmcl.2009.05.108
	51576	259	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmcl.2009.05.108
	CHEMBL278488	259	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmcl.2009.05.108
	11992587	195498	1	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	183	4	3	3	1.3	CCC(C)Nc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	CHEMBL553415	195498	1	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	183	4	3	3	1.3	CCC(C)Nc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	11148966	1122	4	None	4	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	10.1021/jm070022x
	1598	1122	4	None	4	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	10.1021/jm070022x
	CHEMBL436301	1122	4	None	4	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	10.1021/jm070022x
	11380943	83459	1	None	-20	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL219980	83459	1	None	-20	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	11436345	143	0	None	-1	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1599	143	0	None	-1	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL424938	143	0	None	-1	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	9971057	74303	4	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	283	4	1	5	2.2	COc1cccc(Cn2nnc3cc(C(=O)O)ccc32)c1	10.1021/jm051099t
	CHEMBL202427	74303	4	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	283	4	1	5	2.2	COc1cccc(Cn2nnc3cc(C(=O)O)ccc32)c1	10.1021/jm051099t
	28399946	89807	8	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	180	4	2	3	1.6	CCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237733	89807	8	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	180	4	2	3	1.6	CCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11739420	84757	0	None	-12	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	344	2	1	3	2.1	CC1(c2cccc(I)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL223013	84757	0	None	-12	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	344	2	1	3	2.1	CC1(c2cccc(I)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	11413114	137619	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	208	2	1	3	1.4	CC1(C2=CCCC2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL375754	137619	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	208	2	1	3	1.4	CC1(C2=CCCC2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	43271417	90251	1	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	1	4	2.1	CCCN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL238375	90251	1	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	1	4	2.1	CCCN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11992688	195739	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	335	8	2	3	3.4	O=C(O)c1cc(N(CCc2ccccc2)CCc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL557298	195739	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	335	8	2	3	3.4	O=C(O)c1cc(N(CCc2ccccc2)CCc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11514348	153089	6	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	6	2	4	2.9	CCC(CC)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL397616	153089	6	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	6	2	4	2.9	CCC(CC)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	4738197	151305	39	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	240	6	2	5	1.4	COCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL396073	151305	39	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	240	6	2	5	1.4	COCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	653819	141261	50	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	245	2	1	4	2.6	O=C(O)c1ccc2c(c1)nnn2C1CCCCC1	10.1021/jm051099t
	CHEMBL383099	141261	50	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	245	2	1	4	2.6	O=C(O)c1ccc2c(c1)nnn2C1CCCCC1	10.1021/jm051099t
	59343664	75256	0	None	-29	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	272	4	2	4	0.8	O=c1[nH]c(=O)c2c(CCCC(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036951	75256	0	None	-29	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	272	4	2	4	0.8	O=c1[nH]c(=O)c2c(CCCC(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	43187366	90255	5	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	4	2	4	1.4	O=C(O)c1ccc(NCC2CCCO2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL238386	90255	5	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	4	2	4	1.4	O=C(O)c1ccc(NCC2CCCO2)nc1	10.1016/j.bmcl.2007.09.058
	28400003	149289	37	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	180	3	2	3	1.6	CC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL394469	149289	37	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	180	3	2	3	1.6	CC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11184165	83454	0	None	-5	2	Human	5.2	pEC50	=	5.2	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	246	3	1	3	2.0	CCc1cccc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	CHEMBL219950	83454	0	None	-5	2	Human	5.2	pEC50	=	5.2	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	246	3	1	3	2.0	CCc1cccc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	2833647	149867	24	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	1	4	2.1	CCN(CC)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL394907	149867	24	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	1	4	2.1	CCN(CC)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	16775596	89611	3	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	6	1	3	2.4	CCCN(CCC)c1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237525	89611	3	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	6	1	3	2.4	CCCN(CCC)c1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	59304608	75259	0	None	-67	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	262	3	2	4	0.9	O=c1[nH]c(=O)c2c(CCC3CCC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036954	75259	0	None	-67	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	262	3	2	4	0.9	O=c1[nH]c(=O)c2c(CCC3CCC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	11992588	195449	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	197	5	3	3	1.7	CCCC(C)Nc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	CHEMBL552399	195449	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	197	5	3	3	1.7	CCCC(C)Nc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	11379903	84271	0	None	-6	2	Human	6.2	pEC50	=	6.2	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL221282	84271	0	None	-6	2	Human	6.2	pEC50	=	6.2	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	10331019	74413	31	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	4	1	4	1.9	CCCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202586	74413	31	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	4	1	4	1.9	CCCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	28399894	149287	2	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	178	4	2	3	1.4	C=CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL394468	149287	2	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	178	4	2	3	1.4	C=CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	44434380	89610	21	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	192	3	2	3	1.7	O=C(O)c1ccc(NC2CCC2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL237524	89610	21	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	192	3	2	3	1.7	O=C(O)c1ccc(NC2CCC2)nc1	10.1016/j.bmcl.2007.09.058
	44433528	147522	0	None	10	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	178	3	2	4	0.5	CCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL393064	147522	0	None	10	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	178	3	2	4	0.5	CCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	22271415	88524	57	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	152	2	2	3	0.8	CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL235168	88524	57	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	152	2	2	3	0.8	CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	10058774	74417	28	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	3	1	4	1.5	CCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202614	74417	28	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	3	1	4	1.5	CCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	44433530	147524	0	None	2	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	192	4	2	4	0.9	CCCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL393065	147524	0	None	2	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	192	4	2	4	0.9	CCCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	117629482	2823	140	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	1588	2823	140	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	1594	2823	140	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	2835	2823	140	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	938	2823	140	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	CHEMBL573	2823	140	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	DB00627	2823	140	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	11992592	196031	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	211	6	2	3	1.7	CCCN(CCC)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	CHEMBL560254	196031	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	211	6	2	3	1.7	CCCN(CCC)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	11992591	196270	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	307	6	2	3	3.3	O=C(O)c1cc(N(Cc2ccccc2)Cc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL561920	196270	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	307	6	2	3	3.3	O=C(O)c1cc(N(Cc2ccccc2)Cc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11992790	195192	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	343	6	2	3	3.6	O=C(O)c1cc(N(Cc2ccccc2F)Cc2ccccc2F)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL550563	195192	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	343	6	2	3	3.6	O=C(O)c1cc(N(Cc2ccccc2F)Cc2ccccc2F)[nH]n1	10.1016/j.bmcl.2009.05.108
	2103992	169126	46	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	191	2	1	4	1.1	CCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL440217	169126	46	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	191	2	1	4	1.1	CCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	45269904	196732	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	287	6	2	5	2.5	O=C(O)c1cc(N(Cc2ccoc2)Cc2ccoc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL565055	196732	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	287	6	2	5	2.5	O=C(O)c1cc(N(Cc2ccoc2)Cc2ccoc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11608532	73294	31	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	253	3	1	4	2.2	O=C(O)c1ccc2c(c1)nnn2Cc1ccccc1	10.1021/jm051099t
	CHEMBL201278	73294	31	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	253	3	1	4	2.2	O=C(O)c1ccc2c(c1)nnn2Cc1ccccc1	10.1021/jm051099t
	28400019	88566	9	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	196	5	2	4	0.8	COCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL235394	88566	9	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	196	5	2	4	0.8	COCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	56950369	3559	13	None	-47	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	8469	3559	13	None	-47	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	CHEMBL2036958	3559	13	None	-47	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	DB12433	3559	13	None	-47	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	11264843	137620	1	None	-1	2	Human	5.0	pEC50	=	5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	236	2	1	3	1.6	CC1(c2ccc(F)cc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL375762	137620	1	None	-1	2	Human	5.0	pEC50	=	5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	236	2	1	3	1.6	CC1(c2ccc(F)cc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	1595	259	49	None	-4	2	Human	5.5	pIC50	=	5.5	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	51576	259	49	None	-4	2	Human	5.5	pIC50	=	5.5	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	CHEMBL278488	259	49	None	-4	2	Human	5.5	pIC50	=	5.5	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	117629482	2823	140	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	1588	2823	140	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	1594	2823	140	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	2835	2823	140	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	938	2823	140	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	CHEMBL573	2823	140	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	DB00627	2823	140	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	5798	1502	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	6923517	1502	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	9060	1502	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	CHEMBL292303	1502	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	DB03225	1502	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	5797	1475	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	6919011	1475	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	71567	1475	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	CHEMBL379630	1475	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	DB02556	1475	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	11367166	101	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCC[C@@H](CC(=O)O)O	19561068
	2933	101	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCC[C@@H](CC(=O)O)O	19561068
	117629482	2823	140	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	1588	2823	140	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	1594	2823	140	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	2835	2823	140	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	938	2823	140	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	CHEMBL573	2823	140	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	DB00627	2823	140	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	5796	67	77	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCCCC(C(=O)O)O	19561068
	94180	67	77	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCCCC(C(=O)O)O	19561068
	CHEMBL4447980	67	77	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCCCC(C(=O)O)O	19561068
	1152206	1440	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	208	4	3	4	0.3	OC(=O)[C@@H](CC(=O)c1ccccc1N)N	19237584
	5799	1440	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	208	4	3	4	0.3	OC(=O)[C@@H](CC(=O)c1ccccc1N)N	19237584
	6971244	1440	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	208	4	3	4	0.3	OC(=O)[C@@H](CC(=O)c1ccccc1N)N	19237584
	CHEMBL1233899	1440	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	208	4	3	4	0.3	OC(=O)[C@@H](CC(=O)c1ccccc1N)N	19237584
	1597	1965	80	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	16480258
	2736690	1965	80	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	16480258
	CHEMBL381638	1965	80	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	16480258
	12418	1476	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	166	3	2	2	0.7	C1=CC=C(C=C1)C[C@@H](C(=O)O)O	31120900
	444718	1476	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	166	3	2	2	0.7	C1=CC=C(C=C1)C[C@@H](C(=O)O)O	31120900
	DB02494	1476	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	166	3	2	2	0.7	C1=CC=C(C=C1)C[C@@H](C(=O)O)O	31120900
	11715556	120	40	None	-	1	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	17931863
	5801	120	40	None	-	1	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	17931863
	CHEMBL236011	120	40	None	-	1	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	17931863
	44250176	1131	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	19524438
	5800	1131	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	19524438
	CHEMBL564300	1131	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	19524438
	1595	259	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	12522134
	1595	259	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	15929991
	1595	259	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	16389067
	1595	259	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	17358052
	51576	259	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	12522134
	51576	259	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	15929991
	51576	259	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	16389067
	51576	259	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	17358052
	CHEMBL278488	259	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	12522134
	CHEMBL278488	259	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	15929991
	CHEMBL278488	259	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	16389067
	CHEMBL278488	259	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	17358052
	11148966	1122	4	None	4	2	Human	5.3	pEC50	None	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	17358052
	1598	1122	4	None	4	2	Human	5.3	pEC50	None	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	17358052
	CHEMBL436301	1122	4	None	4	2	Human	5.3	pEC50	None	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	17358052
	11436345	143	0	None	-1	2	Human	6.7	pEC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	17358052
	1599	143	0	None	-1	2	Human	6.7	pEC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	17358052
	CHEMBL424938	143	0	None	-1	2	Human	6.7	pEC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	17358052
	53232	188625	95	None	1	10	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	None
	CHEMBL503	188625	95	None	1	10	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	None

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		1595	259	49	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmc.2015.02.018
		51576	259	49	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmc.2015.02.018
		CHEMBL278488	259	49	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmc.2015.02.018
		135899171	16170	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of radioligand from human GPR109BDisplacement of radioligand from human GPR109B	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108
		CHEMBL1224070	16170	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of radioligand from human GPR109BDisplacement of radioligand from human GPR109B	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108

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Main reference

Ligand source activities (1 row/activity)