Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 11715531 | 88731 | None | 13 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 222 | 5 | 2 | 4 | 1.9 | C=CCNc1ccc(C(=O)O)cc1[N+](=O)[O-] | 10.1016/j.bmcl.2007.09.058 | ||
| CHEMBL236013 | 88731 | None | 13 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 222 | 5 | 2 | 4 | 1.9 | C=CCNc1ccc(C(=O)O)cc1[N+](=O)[O-] | 10.1016/j.bmcl.2007.09.058 | ||
| 28400380 | 89951 | None | 1 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 194 | 5 | 2 | 3 | 2.0 | CCCCNc1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2007.09.058 | ||
| CHEMBL237945 | 89951 | None | 1 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 194 | 5 | 2 | 3 | 2.0 | CCCCNc1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2007.09.058 | ||
| 11415838 | 136444 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -1 | 2 | Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation |
ChEMBL | 316 | 2 | 1 | 4 | 2.6 | Cc1sc(C2(C)OC(C(=O)O)=CC2=O)cc1Br | 10.1021/jm070022x | ||
| CHEMBL373484 | 136444 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -1 | 2 | Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation |
ChEMBL | 316 | 2 | 1 | 4 | 2.6 | Cc1sc(C2(C)OC(C(=O)O)=CC2=O)cc1Br | 10.1021/jm070022x | ||
| 28400046 | 89844 | None | 2 | Human | Functional | pEC50 | = | 6.0 | 6.0 | 32 | 2 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 194 | 4 | 2 | 3 | 1.8 | CC(C)CNc1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2007.09.058 | ||
| CHEMBL237737 | 89844 | None | 2 | Human | Functional | pEC50 | = | 6.0 | 6.0 | 32 | 2 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 194 | 4 | 2 | 3 | 1.8 | CC(C)CNc1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2007.09.058 | ||
| 10198518 | 73562 | None | 25 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay |
ChEMBL | 231 | 2 | 1 | 4 | 2.2 | O=C(O)c1ccc2c(c1)nnn2C1CCCC1 | 10.1021/jm051099t | ||
| CHEMBL201724 | 73562 | None | 25 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay |
ChEMBL | 231 | 2 | 1 | 4 | 2.2 | O=C(O)c1ccc2c(c1)nnn2C1CCCC1 | 10.1021/jm051099t | ||
| 24955646 | 58051 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -186 | 4 | Agonist activity at human GPR109bAgonist activity at human GPR109b |
ChEMBL | 310 | 5 | 1 | 4 | 2.9 | CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1 | 10.1021/ml100251u | ||
| CHEMBL1672639 | 58051 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -186 | 4 | Agonist activity at human GPR109bAgonist activity at human GPR109b |
ChEMBL | 310 | 5 | 1 | 4 | 2.9 | CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1 | 10.1021/ml100251u | ||
| 1591 | 131 | None | 45 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -33 | 2 | Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay |
ChEMBL | 168 | 4 | 2 | 2 | 1.5 | CCCCc1cc(n[nH]1)C(=O)O | 10.1016/j.bmcl.2007.07.101 | ||
| 6485181 | 131 | None | 45 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -33 | 2 | Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay |
ChEMBL | 168 | 4 | 2 | 2 | 1.5 | CCCCc1cc(n[nH]1)C(=O)O | 10.1016/j.bmcl.2007.07.101 | ||
| CHEMBL428730 | 131 | None | 45 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -33 | 2 | Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay |
ChEMBL | 168 | 4 | 2 | 2 | 1.5 | CCCCc1cc(n[nH]1)C(=O)O | 10.1016/j.bmcl.2007.07.101 | ||
| 28400196 | 90286 | None | 10 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 266 | 7 | 1 | 4 | 2.9 | CCCN(CCC)c1ccc(C(=O)O)cc1[N+](=O)[O-] | 10.1016/j.bmcl.2007.09.058 | ||
| CHEMBL238376 | 90286 | None | 10 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 266 | 7 | 1 | 4 | 2.9 | CCCN(CCC)c1ccc(C(=O)O)cc1[N+](=O)[O-] | 10.1016/j.bmcl.2007.09.058 | ||
| 44433532 | 152498 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -16 | 2 | Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay |
ChEMBL | 182 | 2 | 2 | 4 | 0.3 | CCc1[nH]nc(-c2nnn[nH]2)c1F | 10.1016/j.bmcl.2007.07.101 | ||
| CHEMBL397055 | 152498 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -16 | 2 | Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay |
ChEMBL | 182 | 2 | 2 | 4 | 0.3 | CCc1[nH]nc(-c2nnn[nH]2)c1F | 10.1016/j.bmcl.2007.07.101 | ||
| 11219885 | 83495 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -3 | 2 | Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation |
ChEMBL | 286 | 2 | 1 | 3 | 2.5 | CC1(c2cccc(C(F)(F)F)c2)OC(C(=O)O)=CC1=O | 10.1021/jm070022x | ||
| CHEMBL220001 | 83495 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -3 | 2 | Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation |
ChEMBL | 286 | 2 | 1 | 3 | 2.5 | CC1(c2cccc(C(F)(F)F)c2)OC(C(=O)O)=CC1=O | 10.1021/jm070022x | ||
| 15604642 | 75280 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -323 | 3 | Agonist activity at human GPR109bAgonist activity at human GPR109b |
ChEMBL | 250 | 3 | 2 | 4 | 0.8 | CC(C)CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12 | 10.1021/ml200243g | ||
| CHEMBL2036948 | 75280 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -323 | 3 | Agonist activity at human GPR109bAgonist activity at human GPR109b |
ChEMBL | 250 | 3 | 2 | 4 | 0.8 | CC(C)CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12 | 10.1021/ml200243g | ||
| 43131474 | 151730 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 208 | 4 | 2 | 3 | 2.2 | CC(C)C(C)Nc1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2007.09.058 | ||
| CHEMBL396382 | 151730 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 208 | 4 | 2 | 3 | 2.2 | CC(C)C(C)Nc1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2007.09.058 | ||
| 11961288 | 199166 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay |
ChEMBL | 313 | 6 | 2 | 4 | 3.4 | O=C(O)c1cc(N(Cc2ccccc2)Cc2ccsc2)[nH]n1 | 10.1016/j.bmcl.2009.05.108 | ||
| CHEMBL564914 | 199166 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay |
ChEMBL | 313 | 6 | 2 | 4 | 3.4 | O=C(O)c1cc(N(Cc2ccccc2)Cc2ccsc2)[nH]n1 | 10.1016/j.bmcl.2009.05.108 | ||
| 15604637 | 75286 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -70 | 3 | Agonist activity at human GPR109bAgonist activity at human GPR109b |
ChEMBL | 262 | 4 | 2 | 4 | 0.9 | O=c1[nH]c(=O)c2c(CCCC3CC3)cc(=O)oc2[nH]1 | 10.1021/ml200243g | ||
| CHEMBL2036955 | 75286 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -70 | 3 | Agonist activity at human GPR109bAgonist activity at human GPR109b |
ChEMBL | 262 | 4 | 2 | 4 | 0.9 | O=c1[nH]c(=O)c2c(CCCC3CC3)cc(=O)oc2[nH]1 | 10.1021/ml200243g | ||
| 11380943 | 83492 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -20 | 2 | Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation |
ChEMBL | 296 | 2 | 1 | 3 | 2.2 | CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O | 10.1021/jm070022x | ||
| CHEMBL219980 | 83492 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -20 | 2 | Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation |
ChEMBL | 296 | 2 | 1 | 3 | 2.2 | CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O | 10.1021/jm070022x | ||
| 45269912 | 198366 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay |
ChEMBL | 319 | 6 | 2 | 5 | 3.4 | O=C(O)c1cc(N(Cc2ccsc2)Cc2cccs2)[nH]n1 | 10.1016/j.bmcl.2009.05.108 | ||
| CHEMBL559204 | 198366 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay |
ChEMBL | 319 | 6 | 2 | 5 | 3.4 | O=C(O)c1cc(N(Cc2ccsc2)Cc2cccs2)[nH]n1 | 10.1016/j.bmcl.2009.05.108 | ||
| 11687485 | 90083 | None | 1 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 254 | 6 | 2 | 5 | 1.7 | COCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-] | 10.1016/j.bmcl.2007.09.058 | ||
| CHEMBL238164 | 90083 | None | 1 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 254 | 6 | 2 | 5 | 1.7 | COCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-] | 10.1016/j.bmcl.2007.09.058 | ||
| 11483496 | 126 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -14 | 2 | Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production |
ChEMBL | 302 | 2 | 1 | 4 | 2.3 | Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O | 10.1021/jm800896z | ||
| 1589 | 126 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -14 | 2 | Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production |
ChEMBL | 302 | 2 | 1 | 4 | 2.3 | Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O | 10.1021/jm800896z | ||
| CHEMBL375493 | 126 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -14 | 2 | Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production |
ChEMBL | 302 | 2 | 1 | 4 | 2.3 | Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O | 10.1021/jm800896z | ||
| 11483496 | 126 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -14 | 2 | Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation |
ChEMBL | 302 | 2 | 1 | 4 | 2.3 | Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O | 10.1021/jm070022x | ||
| 1589 | 126 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -14 | 2 | Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation |
ChEMBL | 302 | 2 | 1 | 4 | 2.3 | Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O | 10.1021/jm070022x | ||
| CHEMBL375493 | 126 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -14 | 2 | Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation |
ChEMBL | 302 | 2 | 1 | 4 | 2.3 | Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O | 10.1021/jm070022x | ||
| 28400406 | 89952 | None | 1 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 208 | 6 | 2 | 3 | 2.4 | CCCCCNc1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2007.09.058 | ||
| CHEMBL237946 | 89952 | None | 1 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 208 | 6 | 2 | 3 | 2.4 | CCCCCNc1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2007.09.058 | ||
| 11528819 | 145594 | None | 15 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 238 | 5 | 2 | 4 | 2.5 | CCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-] | 10.1016/j.bmcl.2007.09.058 | ||
| CHEMBL391473 | 145594 | None | 15 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 238 | 5 | 2 | 4 | 2.5 | CCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-] | 10.1016/j.bmcl.2007.09.058 | ||
| 2829816 | 88781 | None | 35 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 238 | 6 | 2 | 4 | 2.5 | CCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-] | 10.1016/j.bmcl.2007.09.058 | ||
| CHEMBL236219 | 88781 | None | 35 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 238 | 6 | 2 | 4 | 2.5 | CCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-] | 10.1016/j.bmcl.2007.09.058 | ||
| 17965902 | 89848 | None | 3 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 242 | 3 | 2 | 3 | 2.0 | O=C(O)c1ccc(NC(=O)c2ccccc2)nc1 | 10.1016/j.bmcl.2007.09.058 | ||
| CHEMBL237739 | 89848 | None | 3 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay |
ChEMBL | 242 | 3 | 2 | 3 | 2.0 | O=C(O)c1ccc(NC(=O)c2ccccc2)nc1 | 10.1016/j.bmcl.2007.09.058 | ||
| 11379903 | 84305 | None | 0 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -6 | 2 | Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation |
ChEMBL | 258 | 2 | 1 | 4 | 2.2 | CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O | 10.1021/jm070022x | ||
Showing 1 to 50 of 340 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 1595 | 259 | None | 36 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA |
ChEMBL | 218 | 2 | 1 | 3 | 1.5 | OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 | 10.1016/j.bmc.2015.02.018 | ||
| 51576 | 259 | None | 36 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA |
ChEMBL | 218 | 2 | 1 | 3 | 1.5 | OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 | 10.1016/j.bmc.2015.02.018 | ||
| CHEMBL278488 | 259 | None | 36 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA |
ChEMBL | 218 | 2 | 1 | 3 | 1.5 | OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 | 10.1016/j.bmc.2015.02.018 | ||
| 135899171 | 16177 | None | 0 | Human | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | Displacement of radioligand from human GPR109BDisplacement of radioligand from human GPR109B |
ChEMBL | 331 | 6 | 1 | 5 | 2.8 | O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12 | 10.1016/j.bmcl.2010.07.108 | ||
| CHEMBL1224070 | 16177 | None | 0 | Human | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | Displacement of radioligand from human GPR109BDisplacement of radioligand from human GPR109B |
ChEMBL | 331 | 6 | 1 | 5 | 2.8 | O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12 | 10.1016/j.bmcl.2010.07.108 | ||
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