Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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 Assay
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 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
172461075 196528 None 0 Human Functional pEC50 = 7.0 7.0 -2 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 561 17 5 8 3.7 CC(C)(C)OC(=O)NCCNCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5425930 196528 None 0 Human Functional pEC50 = 7.0 7.0 -2 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 561 17 5 8 3.7 CC(C)(C)OC(=O)NCCNCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172457202 196457 None 0 Mouse Functional pEC50 = 6.0 6.0 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 501 12 4 7 3.1 CC(C)(C)OC(=O)NCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5424361 196457 None 0 Mouse Functional pEC50 = 6.0 6.0 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 501 12 4 7 3.1 CC(C)(C)OC(=O)NCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
172444590 195530 None 0 Human Functional pEC50 = 7.0 7.0 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 390 11 4 6 1.7 NCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5405388 195530 None 0 Human Functional pEC50 = 7.0 7.0 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 390 11 4 6 1.7 NCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172470467 197125 None 0 Human Functional pEC50 = 5.9 5.9 -9 2
Agonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay
ChEMBL 567 15 4 11 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL5439297 197125 None 0 Human Functional pEC50 = 5.9 5.9 -9 2
Agonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay
ChEMBL 567 15 4 11 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
172461948 196818 None 0 Human Functional pEC50 = 5.9 5.9 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 517 13 4 8 2.3 CC(C)(C)OC(=O)NCCOCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5432813 196818 None 0 Human Functional pEC50 = 5.9 5.9 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 517 13 4 8 2.3 CC(C)(C)OC(=O)NCCOCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
172447016 195443 None 0 Mouse Functional pEC50 = 6.9 6.9 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 404 12 4 6 2.1 NCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5403958 195443 None 0 Mouse Functional pEC50 = 6.9 6.9 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 404 12 4 6 2.1 NCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172471932 197160 None 0 Mouse Functional pEC50 = 5.9 5.9 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 487 11 4 7 2.7 CC(C)(C)OC(=O)NCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5440093 197160 None 0 Mouse Functional pEC50 = 5.9 5.9 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 487 11 4 7 2.7 CC(C)(C)OC(=O)NCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
172457202 196457 None 0 Human Functional pEC50 = 5.9 5.9 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 501 12 4 7 3.1 CC(C)(C)OC(=O)NCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5424361 196457 None 0 Human Functional pEC50 = 5.9 5.9 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 501 12 4 7 3.1 CC(C)(C)OC(=O)NCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
172471932 197160 None 0 Human Functional pEC50 = 5.9 5.9 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 487 11 4 7 2.7 CC(C)(C)OC(=O)NCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5440093 197160 None 0 Human Functional pEC50 = 5.9 5.9 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 487 11 4 7 2.7 CC(C)(C)OC(=O)NCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
171378461 197076 None 0 Human Functional pEC50 = 6.8 6.8 -2 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 624 19 5 12 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL5438140 197076 None 0 Human Functional pEC50 = 6.8 6.8 -2 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 624 19 5 12 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
172470467 197125 None 0 Human Functional pEC50 = 5.8 5.8 -9 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 567 15 4 11 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL5439297 197125 None 0 Human Functional pEC50 = 5.8 5.8 -9 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 567 15 4 11 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
172447016 195443 None 0 Human Functional pEC50 = 6.8 6.8 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 404 12 4 6 2.1 NCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5403958 195443 None 0 Human Functional pEC50 = 6.8 6.8 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 404 12 4 6 2.1 NCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172461697 196647 None 0 Human Functional pEC50 = 5.8 5.8 1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 529 14 4 7 3.9 CC(C)(C)OC(=O)NCCCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5428882 196647 None 0 Human Functional pEC50 = 5.8 5.8 1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 529 14 4 7 3.9 CC(C)(C)OC(=O)NCCCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
1110 3698 None 67 Human Functional pEC50 = 4.8 4.8 -1 2
Agonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
21952380 3698 None 67 Human Functional pEC50 = 4.8 4.8 -1 2
Agonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
2487 3698 None 67 Human Functional pEC50 = 4.8 4.8 -1 2
Agonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
3637 3698 None 67 Human Functional pEC50 = 4.8 4.8 -1 2
Agonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL576 3698 None 67 Human Functional pEC50 = 4.8 4.8 -1 2
Agonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
DB00139 3698 None 67 Human Functional pEC50 = 4.8 4.8 -1 2
Agonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
172462290 196722 None 0 Human Functional pEC50 = 5.8 5.8 1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 515 13 4 7 3.5 CC(C)(C)OC(=O)NCCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5430763 196722 None 0 Human Functional pEC50 = 5.8 5.8 1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 515 13 4 7 3.5 CC(C)(C)OC(=O)NCCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
172461697 196647 None 0 Mouse Functional pEC50 = 5.8 5.8 -1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 529 14 4 7 3.9 CC(C)(C)OC(=O)NCCCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5428882 196647 None 0 Mouse Functional pEC50 = 5.8 5.8 -1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 529 14 4 7 3.9 CC(C)(C)OC(=O)NCCCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
172470467 197125 None 0 Mouse Functional pEC50 = 6.7 6.7 9 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 567 15 4 11 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL5439297 197125 None 0 Mouse Functional pEC50 = 6.7 6.7 9 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 567 15 4 11 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
1110 3698 None 67 Mouse Functional pEC50 = 5.7 5.7 1 2
Agonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
21952380 3698 None 67 Mouse Functional pEC50 = 5.7 5.7 1 2
Agonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
2487 3698 None 67 Mouse Functional pEC50 = 5.7 5.7 1 2
Agonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
3637 3698 None 67 Mouse Functional pEC50 = 5.7 5.7 1 2
Agonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL576 3698 None 67 Mouse Functional pEC50 = 5.7 5.7 1 2
Agonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
DB00139 3698 None 67 Mouse Functional pEC50 = 5.7 5.7 1 2
Agonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
172462290 196722 None 0 Mouse Functional pEC50 = 5.7 5.7 -1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 515 13 4 7 3.5 CC(C)(C)OC(=O)NCCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5430763 196722 None 0 Mouse Functional pEC50 = 5.7 5.7 -1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 515 13 4 7 3.5 CC(C)(C)OC(=O)NCCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
172471391 197165 None 0 Human Functional pEC50 = 5.7 5.7 -8 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 504 13 4 7 3.7 CC(C)(C)OC(=O)NCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5440168 197165 None 0 Human Functional pEC50 = 5.7 5.7 -8 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 504 13 4 7 3.7 CC(C)(C)OC(=O)NCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172449130 195582 None 0 Human Functional pEC50 = 6.6 6.6 -3 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 446 14 3 6 3.1 CN(C)CCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5406481 195582 None 0 Human Functional pEC50 = 6.6 6.6 -3 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 446 14 3 6 3.1 CN(C)CCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
169205458 196510 None 0 Human Functional pEC50 = 6.6 6.6 -2 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 347 8 3 5 2.0 CCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5425639 196510 None 0 Human Functional pEC50 = 6.6 6.6 -2 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 347 8 3 5 2.0 CCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172471391 197165 None 0 Mouse Functional pEC50 = 6.6 6.6 8 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 504 13 4 7 3.7 CC(C)(C)OC(=O)NCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5440168 197165 None 0 Mouse Functional pEC50 = 6.6 6.6 8 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 504 13 4 7 3.7 CC(C)(C)OC(=O)NCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172469654 197067 None 0 Human Functional pEC50 = 5.6 5.6 -6 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 518 14 4 7 4.1 CC(C)(C)OC(=O)NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5437967 197067 None 0 Human Functional pEC50 = 5.6 5.6 -6 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 518 14 4 7 4.1 CC(C)(C)OC(=O)NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172450162 195860 None 0 Human Functional pEC50 = 6.6 6.6 -5 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 432 14 4 6 2.8 CNCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5412124 195860 None 0 Human Functional pEC50 = 6.6 6.6 -5 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 432 14 4 6 2.8 CNCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
137553168 196727 None 3 Mouse Functional pEC50 = 6.6 6.6 -7 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 398 7 3 5 2.3 O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(OC(F)(F)F)cc2)n1)C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL5430997 196727 None 3 Mouse Functional pEC50 = 6.6 6.6 -7 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 398 7 3 5 2.3 O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(OC(F)(F)F)cc2)n1)C(=O)O 10.1021/acs.jmedchem.3c00552
172469172 197009 None 0 Human Functional pEC50 = 5.5 5.5 -5 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 506 13 4 8 2.5 CC(C)(C)OC(=O)NCCOCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5436642 197009 None 0 Human Functional pEC50 = 5.5 5.5 -5 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 506 13 4 8 2.5 CC(C)(C)OC(=O)NCCOCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172460779 196196 None 0 Mouse Functional pEC50 = 6.5 6.5 17 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 490 12 4 7 3.3 CC(C)(C)OC(=O)NCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5418626 196196 None 0 Mouse Functional pEC50 = 6.5 6.5 17 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 490 12 4 7 3.3 CC(C)(C)OC(=O)NCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
1110 3698 None 67 Human Functional pEC50 = 4.5 4.5 -1 2
Agonist activity at human succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assayAgonist activity at human succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
21952380 3698 None 67 Human Functional pEC50 = 4.5 4.5 -1 2
Agonist activity at human succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assayAgonist activity at human succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
2487 3698 None 67 Human Functional pEC50 = 4.5 4.5 -1 2
Agonist activity at human succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assayAgonist activity at human succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
3637 3698 None 67 Human Functional pEC50 = 4.5 4.5 -1 2
Agonist activity at human succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assayAgonist activity at human succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL576 3698 None 67 Human Functional pEC50 = 4.5 4.5 -1 2
Agonist activity at human succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assayAgonist activity at human succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
DB00139 3698 None 67 Human Functional pEC50 = 4.5 4.5 -1 2
Agonist activity at human succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assayAgonist activity at human succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
172447933 195873 None 0 Human Functional pEC50 = 7.4 7.4 1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 418 13 4 6 2.5 NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5412414 195873 None 0 Human Functional pEC50 = 7.4 7.4 1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 418 13 4 6 2.5 NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
137553168 196727 None 3 Human Functional pEC50 = 7.4 7.4 7 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 398 7 3 5 2.3 O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(OC(F)(F)F)cc2)n1)C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL5430997 196727 None 3 Human Functional pEC50 = 7.4 7.4 7 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 398 7 3 5 2.3 O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(OC(F)(F)F)cc2)n1)C(=O)O 10.1021/acs.jmedchem.3c00552
172469654 197067 None 0 Mouse Functional pEC50 = 6.4 6.4 6 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 518 14 4 7 4.1 CC(C)(C)OC(=O)NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5437967 197067 None 0 Mouse Functional pEC50 = 6.4 6.4 6 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 518 14 4 7 4.1 CC(C)(C)OC(=O)NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172461075 196528 None 0 Mouse Functional pEC50 = 7.4 7.4 2 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 561 17 5 8 3.7 CC(C)(C)OC(=O)NCCNCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5425930 196528 None 0 Mouse Functional pEC50 = 7.4 7.4 2 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 561 17 5 8 3.7 CC(C)(C)OC(=O)NCCNCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172469763 197040 None 0 Human Functional pEC50 = 5.4 5.4 -7 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 476 11 4 7 2.9 CC(C)(C)OC(=O)NCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5437321 197040 None 0 Human Functional pEC50 = 5.4 5.4 -7 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 476 11 4 7 2.9 CC(C)(C)OC(=O)NCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172450162 195860 None 0 Mouse Functional pEC50 = 7.4 7.4 5 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 432 14 4 6 2.8 CNCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5412124 195860 None 0 Mouse Functional pEC50 = 7.4 7.4 5 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 432 14 4 6 2.8 CNCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
1110 3698 None 67 Mouse Functional pEC50 = 5.3 5.3 1 2
Agonist activity at mouse succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assayAgonist activity at mouse succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
21952380 3698 None 67 Mouse Functional pEC50 = 5.3 5.3 1 2
Agonist activity at mouse succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assayAgonist activity at mouse succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
2487 3698 None 67 Mouse Functional pEC50 = 5.3 5.3 1 2
Agonist activity at mouse succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assayAgonist activity at mouse succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
3637 3698 None 67 Mouse Functional pEC50 = 5.3 5.3 1 2
Agonist activity at mouse succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assayAgonist activity at mouse succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL576 3698 None 67 Mouse Functional pEC50 = 5.3 5.3 1 2
Agonist activity at mouse succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assayAgonist activity at mouse succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
DB00139 3698 None 67 Mouse Functional pEC50 = 5.3 5.3 1 2
Agonist activity at mouse succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assayAgonist activity at mouse succinate receptor 1 expressed in HEK293T cells co-transfected with Galphai-Rluc8/Ggamma8-GFP2/Gbeta3 assessed as G protein activation incubated for 5 mins by luminescence based BRET assay
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
172469172 197009 None 0 Mouse Functional pEC50 = 6.3 6.3 5 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 506 13 4 8 2.5 CC(C)(C)OC(=O)NCCOCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5436642 197009 None 0 Mouse Functional pEC50 = 6.3 6.3 5 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 506 13 4 8 2.5 CC(C)(C)OC(=O)NCCOCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172469763 197040 None 0 Mouse Functional pEC50 = 6.3 6.3 7 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 476 11 4 7 2.9 CC(C)(C)OC(=O)NCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5437321 197040 None 0 Mouse Functional pEC50 = 6.3 6.3 7 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 476 11 4 7 2.9 CC(C)(C)OC(=O)NCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172460779 196196 None 0 Human Functional pEC50 = 5.2 5.2 -17 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 490 12 4 7 3.3 CC(C)(C)OC(=O)NCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5418626 196196 None 0 Human Functional pEC50 = 5.2 5.2 -17 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 490 12 4 7 3.3 CC(C)(C)OC(=O)NCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172447933 195873 None 0 Mouse Functional pEC50 = 7.2 7.2 -1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 418 13 4 6 2.5 NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5412414 195873 None 0 Mouse Functional pEC50 = 7.2 7.2 -1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 418 13 4 6 2.5 NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172449130 195582 None 0 Mouse Functional pEC50 = 7.2 7.2 3 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 446 14 3 6 3.1 CN(C)CCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5406481 195582 None 0 Mouse Functional pEC50 = 7.2 7.2 3 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 446 14 3 6 3.1 CN(C)CCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
171378461 197076 None 0 Mouse Functional pEC50 = 7.2 7.2 2 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 624 19 5 12 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL5438140 197076 None 0 Mouse Functional pEC50 = 7.2 7.2 2 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 624 19 5 12 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
172444590 195530 None 0 Mouse Functional pEC50 = 7.1 7.1 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 390 11 4 6 1.7 NCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5405388 195530 None 0 Mouse Functional pEC50 = 7.1 7.1 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 390 11 4 6 1.7 NCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172446350 195214 None 0 Mouse Functional pEC50 = 7.1 7.1 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 376 10 4 6 1.3 NCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5399023 195214 None 0 Mouse Functional pEC50 = 7.1 7.1 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 376 10 4 6 1.3 NCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172470467 197125 None 0 Mouse Functional pEC50 = 7.1 7.1 9 2
Agonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay
ChEMBL 567 15 4 11 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL5439297 197125 None 0 Mouse Functional pEC50 = 7.1 7.1 9 2
Agonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay
ChEMBL 567 15 4 11 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
1110 3698 None 67 Human Functional pEC50 = 5.0 5.0 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
21952380 3698 None 67 Human Functional pEC50 = 5.0 5.0 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
2487 3698 None 67 Human Functional pEC50 = 5.0 5.0 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
3637 3698 None 67 Human Functional pEC50 = 5.0 5.0 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL576 3698 None 67 Human Functional pEC50 = 5.0 5.0 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
DB00139 3698 None 67 Human Functional pEC50 = 5.0 5.0 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
172446350 195214 None 0 Human Functional pEC50 = 7.0 7.0 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 376 10 4 6 1.3 NCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5399023 195214 None 0 Human Functional pEC50 = 7.0 7.0 -1 2
Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 376 10 4 6 1.3 NCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
1110 3698 None 67 Mouse Functional pEC50 = 5.0 5.0 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
21952380 3698 None 67 Mouse Functional pEC50 = 5.0 5.0 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
2487 3698 None 67 Mouse Functional pEC50 = 5.0 5.0 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
3637 3698 None 67 Mouse Functional pEC50 = 5.0 5.0 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL576 3698 None 67 Mouse Functional pEC50 = 5.0 5.0 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
DB00139 3698 None 67 Mouse Functional pEC50 = 5.0 5.0 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 118 3 2 2 -0.1 OC(=O)CCC(=O)O 10.1021/acs.jmedchem.3c00552
169205458 196510 None 0 Mouse Functional pEC50 = 7.0 7.0 2 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 347 8 3 5 2.0 CCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5425639 196510 None 0 Mouse Functional pEC50 = 7.0 7.0 2 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 347 8 3 5 2.0 CCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172461948 196818 None 0 Mouse Functional pEC50 = 6.0 6.0 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 517 13 4 8 2.3 CC(C)(C)OC(=O)NCCOCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5432813 196818 None 0 Mouse Functional pEC50 = 6.0 6.0 1 2
Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis
ChEMBL 517 13 4 8 2.3 CC(C)(C)OC(=O)NCCOCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 10.1021/acs.jmedchem.3c00552
71454870 80992 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 444 6 0 5 6.3 Fc1ccc(-c2ccc(-c3nnc(CCCc4ccc5cccnc5n4)o3)cc2)cc1Cl 10.1016/j.bmcl.2011.04.091
CHEMBL2153587 80992 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 444 6 0 5 6.3 Fc1ccc(-c2ccc(-c3nnc(CCCc4ccc5cccnc5n4)o3)cc2)cc1Cl 10.1016/j.bmcl.2011.04.091
71460332 80964 None 5 Rat Functional pIC50 = 7 7.0 -9 3
Antagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 429 7 1 3 6.2 C[C@H](NC(=O)CCCc1ccc2cccnc2n1)c1ccc(-c2cccc(Cl)c2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153446 80964 None 5 Rat Functional pIC50 = 7 7.0 -9 3
Antagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 429 7 1 3 6.2 C[C@H](NC(=O)CCCc1ccc2cccnc2n1)c1ccc(-c2cccc(Cl)c2)cc1 10.1016/j.bmcl.2011.04.091
71460331 80956 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 381 7 1 3 4.9 O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153438 80956 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 381 7 1 3 4.9 O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2011.04.091
71449506 80965 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 411 8 1 4 4.9 COc1cccc(-c2ccc(CNC(=O)CCCc3ccc4cccnc4n3)cc2)c1 10.1016/j.bmcl.2011.04.091
CHEMBL2153447 80965 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 411 8 1 4 4.9 COc1cccc(-c2ccc(CNC(=O)CCCc3ccc4cccnc4n3)cc2)c1 10.1016/j.bmcl.2011.04.091
71449521 80989 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 459 7 1 6 4.5 O=C(CCCc1ccc2cccnc2n1)NCc1nnc(-c2ccc(F)c(C(F)(F)F)c2)o1 10.1016/j.bmcl.2011.04.091
CHEMBL2153584 80989 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 459 7 1 6 4.5 O=C(CCCc1ccc2cccnc2n1)NCc1nnc(-c2ccc(F)c(C(F)(F)F)c2)o1 10.1016/j.bmcl.2011.04.091
71458498 80996 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 443 6 1 4 6.1 Fc1ccc(-c2ccc(-c3nnc(CCCc4ccc5cccnc5n4)[nH]3)cc2)cc1Cl 10.1016/j.bmcl.2011.04.091
CHEMBL2153590 80996 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 443 6 1 4 6.1 Fc1ccc(-c2ccc(-c3nnc(CCCc4ccc5cccnc5n4)[nH]3)cc2)cc1Cl 10.1016/j.bmcl.2011.04.091
71460332 80964 None 5 Human Functional pIC50 = 8.0 8.0 9 3
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 429 7 1 3 6.2 C[C@H](NC(=O)CCCc1ccc2cccnc2n1)c1ccc(-c2cccc(Cl)c2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153446 80964 None 5 Human Functional pIC50 = 8.0 8.0 9 3
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 429 7 1 3 6.2 C[C@H](NC(=O)CCCc1ccc2cccnc2n1)c1ccc(-c2cccc(Cl)c2)cc1 10.1016/j.bmcl.2011.04.091
172440758 195541 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 379 5 2 2 5.2 Cc1c(C(=O)Nc2ccccc2CC(=O)O)cccc1-c1ccc(Cl)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5405575 195541 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 379 5 2 2 5.2 Cc1c(C(=O)Nc2ccccc2CC(=O)O)cccc1-c1ccc(Cl)cc1 10.1021/acs.jmedchem.3c00552
71462027 80958 None 0 Rat Functional pIC50 = 6.9 6.9 -2 3
Antagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 415 7 1 3 5.6 O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2cccc(Cl)c2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153440 80958 None 0 Rat Functional pIC50 = 6.9 6.9 -2 3
Antagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 415 7 1 3 5.6 O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2cccc(Cl)c2)cc1 10.1016/j.bmcl.2011.04.091
162670620 183073 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 380 6 2 3 4.3 O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(Cl)cc2)c1)c1cccnc1 10.1021/acs.jmedchem.0c01020
CHEMBL4793036 183073 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 380 6 2 3 4.3 O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(Cl)cc2)c1)c1cccnc1 10.1021/acs.jmedchem.0c01020
172444130 195500 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 446 12 3 4 5.1 NCCCCCCOc1ccc(-c2cccc(C(=O)Nc3ccccc3CC(=O)O)c2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5404924 195500 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 446 12 3 4 5.1 NCCCCCCOc1ccc(-c2cccc(C(=O)Nc3ccccc3CC(=O)O)c2)cc1 10.1021/acs.jmedchem.3c00552
162646878 179663 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 383 5 2 2 5.0 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)cc2)c1F 10.1021/acs.jmedchem.0c01020
CHEMBL4741728 179663 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 383 5 2 2 5.0 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)cc2)c1F 10.1021/acs.jmedchem.0c01020
162664232 182185 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 365 5 2 2 4.9 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)cc2)c1 10.1021/acs.jmedchem.0c01020
CHEMBL4781545 182185 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 365 5 2 2 4.9 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)cc2)c1 10.1021/acs.jmedchem.0c01020
53358901 1125 None 13 Rat Functional pIC50 = 6.9 6.9 -3 2
Antagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 458 7 1 5 5.1 O=C(NCc1onc(c1)c1ccc(c(c1)C(F)(F)F)F)CCCc1ccc2c(n1)nccc2 10.1016/j.bmcl.2011.04.091
5514 1125 None 13 Rat Functional pIC50 = 6.9 6.9 -3 2
Antagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 458 7 1 5 5.1 O=C(NCc1onc(c1)c1ccc(c(c1)C(F)(F)F)F)CCCc1ccc2c(n1)nccc2 10.1016/j.bmcl.2011.04.091
CHEMBL2153581 1125 None 13 Rat Functional pIC50 = 6.9 6.9 -3 2
Antagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 458 7 1 5 5.1 O=C(NCc1onc(c1)c1ccc(c(c1)C(F)(F)F)F)CCCc1ccc2c(n1)nccc2 10.1016/j.bmcl.2011.04.091
71453124 80974 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 557 6 1 3 8.3 C[C@H](NC(=O)C(C)(C)c1ccc(-c2ccc3cccnc3n2)cc1)c1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153465 80974 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 557 6 1 3 8.3 C[C@H](NC(=O)C(C)(C)c1ccc(-c2ccc3cccnc3n2)cc1)c1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
162648855 179954 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 464 7 3 4 5.0 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)c(OC3CCNCC3)c2)c1 10.1021/acs.jmedchem.0c01020
CHEMBL4745252 179954 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 464 7 3 4 5.0 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)c(OC3CCNCC3)c2)c1 10.1021/acs.jmedchem.0c01020
162665674 182339 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 450 7 3 4 4.6 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)c(OC3CCNC3)c2)c1 10.1021/acs.jmedchem.0c01020
CHEMBL4783334 182339 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 450 7 3 4 4.6 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)c(OC3CCNC3)c2)c1 10.1021/acs.jmedchem.0c01020
162671190 182959 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 436 7 3 4 4.2 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1 10.1021/acs.jmedchem.0c01020
CHEMBL4791540 182959 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 436 7 3 4 4.2 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1 10.1021/acs.jmedchem.0c01020
172468605 197054 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 572 10 3 6 4.9 CC(C)(C)OC(=O)NCCN1CCN(Cc2ccc(-c3cccc(C(=O)Nc4ccccc4CC(=O)O)c3)cc2)CC1 10.1021/acs.jmedchem.3c00552
CHEMBL5437674 197054 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 572 10 3 6 4.9 CC(C)(C)OC(=O)NCCN1CCN(Cc2ccc(-c3cccc(C(=O)Nc4ccccc4CC(=O)O)c3)cc2)CC1 10.1021/acs.jmedchem.3c00552
71453121 80963 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 463 7 1 3 6.5 CC(NC(=O)CCCc1ccc2cccnc2n1)c1ccc(-c2cccc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153445 80963 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 463 7 1 3 6.5 CC(NC(=O)CCCc1ccc2cccnc2n1)c1ccc(-c2cccc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
71460333 80977 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 613 6 2 4 7.7 C[C@H](NC(=O)C(O)(c1ccc(-c2ccc3cccnc3n2)cc1)C(F)(F)F)c1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153468 80977 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 613 6 2 4 7.7 C[C@H](NC(=O)C(O)(c1ccc(-c2ccc3cccnc3n2)cc1)C(F)(F)F)c1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
71451318 81001 None 0 Human Functional pIC50 = 6.8 6.8 2 2
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 432 6 0 5 5.9 FC(F)(F)c1cc(-c2nnc(CCCCc3ccc4cccnc4n3)o2)ccc1Cl 10.1016/j.bmcl.2011.04.091
CHEMBL2153596 81001 None 0 Human Functional pIC50 = 6.8 6.8 2 2
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 432 6 0 5 5.9 FC(F)(F)c1cc(-c2nnc(CCCCc3ccc4cccnc4n3)o2)ccc1Cl 10.1016/j.bmcl.2011.04.091
172470948 197152 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 379 5 2 2 5.2 Cc1ccc(C(=O)Nc2ccccc2CC(=O)O)cc1-c1ccc(Cl)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5439938 197152 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 379 5 2 2 5.2 Cc1ccc(C(=O)Nc2ccccc2CC(=O)O)cc1-c1ccc(Cl)cc1 10.1021/acs.jmedchem.3c00552
71458486 80971 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 543 6 1 3 7.7 CC(C)(C(=O)NCc1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1)c1ccc(-c2ccc3cccnc3n2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153462 80971 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 543 6 1 3 7.7 CC(C)(C(=O)NCc1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1)c1ccc(-c2ccc3cccnc3n2)cc1 10.1016/j.bmcl.2011.04.091
71456642 80999 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 466 6 0 5 6.3 FC(F)(F)c1ccc(-c2nnc(CCCCc3ccc4cccnc4n3)o2)cc1C(F)(F)F 10.1016/j.bmcl.2011.04.091
CHEMBL2153594 80999 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 466 6 0 5 6.3 FC(F)(F)c1ccc(-c2nnc(CCCCc3ccc4cccnc4n3)o2)cc1C(F)(F)F 10.1016/j.bmcl.2011.04.091
172446384 195262 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 651 12 3 10 4.3 Cc1cc(CN2CCN(CCNC3C=CC([N+](=O)[O-])c4nonc43)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
CHEMBL5399663 195262 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 651 12 3 10 4.3 Cc1cc(CN2CCN(CCNC3C=CC([N+](=O)[O-])c4nonc43)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
71462032 80976 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 545 6 2 4 7.0 C[C@H](NC(=O)C(O)c1ccc(-c2ccc3cccnc3n2)cc1)c1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153467 80976 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 545 6 2 4 7.0 C[C@H](NC(=O)C(O)c1ccc(-c2ccc3cccnc3n2)cc1)c1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
71449523 81000 None 1 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 448 7 0 6 5.8 FC(F)(F)Oc1ccc(-c2nnc(CCCCc3ccc4cccnc4n3)o2)cc1Cl 10.1016/j.bmcl.2011.04.091
CHEMBL2153595 81000 None 1 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 448 7 0 6 5.8 FC(F)(F)Oc1ccc(-c2nnc(CCCCc3ccc4cccnc4n3)o2)cc1Cl 10.1016/j.bmcl.2011.04.091
172440326 195012 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 460 12 3 4 5.4 Cc1cc(OCCCCCCN)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
CHEMBL5394935 195012 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 460 12 3 4 5.4 Cc1cc(OCCCCCCN)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
71449508 80975 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 565 6 1 3 8.1 C[C@H](NC(=O)C(F)(F)c1ccc(-c2ccc3cccnc3n2)cc1)c1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153466 80975 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 565 6 1 3 8.1 C[C@H](NC(=O)C(F)(F)c1ccc(-c2ccc3cccnc3n2)cc1)c1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
162656033 180792 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 482 7 3 4 5.2 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)c(O[C@@H]3CCCNC3)c2)c1F 10.1021/acs.jmedchem.0c01020
CHEMBL4755411 180792 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 482 7 3 4 5.2 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)c(O[C@@H]3CCCNC3)c2)c1F 10.1021/acs.jmedchem.0c01020
71451310 80980 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 469 7 1 5 4.9 O=C(CCCc1ccc2cccnc2n1)NCc1ncc(-c2ccc(F)c(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2011.04.091
CHEMBL2153470 80980 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 469 7 1 5 4.9 O=C(CCCc1ccc2cccnc2n1)NCc1ncc(-c2ccc(F)c(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2011.04.091
71458497 80993 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 460 6 0 5 6.5 FC(F)(F)c1cccc(-c2ccc(-c3nnc(CCCc4ccc5cccnc5n4)o3)cc2)c1 10.1016/j.bmcl.2011.04.091
CHEMBL2153588 80993 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 460 6 0 5 6.5 FC(F)(F)c1cccc(-c2ccc(-c3nnc(CCCc4ccc5cccnc5n4)o3)cc2)c1 10.1016/j.bmcl.2011.04.091
71449524 81002 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 416 6 0 5 5.4 Fc1ccc(-c2nnc(CCCCc3ccc4cccnc4n3)o2)cc1C(F)(F)F 10.1016/j.bmcl.2011.04.091
CHEMBL2153597 81002 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 416 6 0 5 5.4 Fc1ccc(-c2nnc(CCCCc3ccc4cccnc4n3)o2)cc1C(F)(F)F 10.1016/j.bmcl.2011.04.091
71462034 80982 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 457 7 1 5 4.6 O=C(CCCc1ccc2cccnc2n1)NCc1cnn(-c2ccc(F)c(C(F)(F)F)c2)c1 10.1016/j.bmcl.2011.04.091
CHEMBL2153472 80982 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 457 7 1 5 4.6 O=C(CCCc1ccc2cccnc2n1)NCc1cnn(-c2ccc(F)c(C(F)(F)F)c2)c1 10.1016/j.bmcl.2011.04.091
71451308 80959 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 467 7 1 3 6.1 O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153441 80959 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 467 7 1 3 6.1 O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
162644696 179527 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 351 4 2 2 5.0 O=C(Nc1ccccc1C(=O)O)c1cccc(-c2ccc(Cl)cc2)c1 10.1021/acs.jmedchem.0c01020
CHEMBL4740249 179527 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 351 4 2 2 5.0 O=C(Nc1ccccc1C(=O)O)c1cccc(-c2ccc(Cl)cc2)c1 10.1021/acs.jmedchem.0c01020
10519 2813 None 27 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 10.1021/acs.jmedchem.0c01020
138811017 2813 None 27 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 10.1021/acs.jmedchem.0c01020
CHEMBL4790324 2813 None 27 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 10.1021/acs.jmedchem.0c01020
71458496 80990 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 475 7 1 6 4.9 O=C(CCCc1ccc2cccnc2n1)NCc1nnc(-c2ccc(F)c(C(F)(F)F)c2)s1 10.1016/j.bmcl.2011.04.091
CHEMBL2153585 80990 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 475 7 1 6 4.9 O=C(CCCc1ccc2cccnc2n1)NCc1nnc(-c2ccc(F)c(C(F)(F)F)c2)s1 10.1016/j.bmcl.2011.04.091
162664841 182210 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 424 8 3 4 4.2 NCCOc1cc(-c2cccc(C(=O)Nc3ccccc3CC(=O)O)c2)ccc1Cl 10.1021/acs.jmedchem.0c01020
CHEMBL4781889 182210 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 424 8 3 4 4.2 NCCOc1cc(-c2cccc(C(=O)Nc3ccccc3CC(=O)O)c2)ccc1Cl 10.1021/acs.jmedchem.0c01020
90480064 172460 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 360 6 3 3 3.7 NCc1cccc(-c2cccc(C(=O)Nc3ccccc3CC(=O)O)c2)c1 10.1021/acs.jmedchem.0c01020
CHEMBL4475961 172460 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 360 6 3 3 3.7 NCc1cccc(-c2cccc(C(=O)Nc3ccccc3CC(=O)O)c2)c1 10.1021/acs.jmedchem.0c01020
53358900 80957 None 1 Human Functional pIC50 = 7.5 7.5 -4 2
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 395 7 1 3 5.2 Cc1cccc(-c2ccc(CNC(=O)CCCc3ccc4cccnc4n3)cc2)c1 10.1016/j.bmcl.2011.04.091
CHEMBL2153439 80957 None 1 Human Functional pIC50 = 7.5 7.5 -4 2
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 395 7 1 3 5.2 Cc1cccc(-c2ccc(CNC(=O)CCCc3ccc4cccnc4n3)cc2)c1 10.1016/j.bmcl.2011.04.091
71456626 80967 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 429 7 1 3 5.9 Cc1cc(-c2ccc(CNC(=O)CCCc3ccc4cccnc4n3)cc2)ccc1Cl 10.1016/j.bmcl.2011.04.091
CHEMBL2153457 80967 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 429 7 1 3 5.9 Cc1cc(-c2ccc(CNC(=O)CCCc3ccc4cccnc4n3)cc2)ccc1Cl 10.1016/j.bmcl.2011.04.091
71453139 80988 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 422 7 1 5 5.0 O=C(CCCc1ccc2cccnc2n1)NCc1nc(-c2cccc(Cl)c2)cs1 10.1016/j.bmcl.2011.04.091
CHEMBL2153583 80988 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 422 7 1 5 5.0 O=C(CCCc1ccc2cccnc2n1)NCc1nc(-c2cccc(Cl)c2)cs1 10.1016/j.bmcl.2011.04.091
162646617 179775 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 394 6 3 3 4.3 NCc1cc(-c2cccc(C(=O)Nc3ccccc3CC(=O)O)c2)ccc1Cl 10.1021/acs.jmedchem.0c01020
CHEMBL4743401 179775 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 394 6 3 3 4.3 NCc1cc(-c2cccc(C(=O)Nc3ccccc3CC(=O)O)c2)ccc1Cl 10.1021/acs.jmedchem.0c01020
71449522 80994 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 442 6 0 5 6.6 Clc1cccc(-c2ccc(-c3nnc(CCCc4ccc5cccnc5n4)s3)cc2)c1 10.1016/j.bmcl.2011.04.091
CHEMBL2153589 80994 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 442 6 0 5 6.6 Clc1cccc(-c2ccc(-c3nnc(CCCc4ccc5cccnc5n4)s3)cc2)c1 10.1016/j.bmcl.2011.04.091
71451316 80997 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 398 6 0 5 5.3 FC(F)(F)c1ccc(-c2nnc(CCCCc3ccc4cccnc4n3)o2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153591 80997 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 398 6 0 5 5.3 FC(F)(F)c1ccc(-c2nnc(CCCCc3ccc4cccnc4n3)o2)cc1 10.1016/j.bmcl.2011.04.091
71454871 80998 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 414 7 0 6 5.1 FC(F)(F)Oc1ccc(-c2nnc(CCCCc3ccc4cccnc4n3)o2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153592 80998 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 414 7 0 6 5.1 FC(F)(F)Oc1ccc(-c2nnc(CCCCc3ccc4cccnc4n3)o2)cc1 10.1016/j.bmcl.2011.04.091
71456627 80968 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 481 6 1 3 6.6 O=C(Cc1ccc(-c2ccc3cccnc3n2)cc1)NCc1ccc(-c2ccc(F)c(Cl)c2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153459 80968 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 481 6 1 3 6.6 O=C(Cc1ccc(-c2ccc3cccnc3n2)cc1)NCc1ccc(-c2ccc(F)c(Cl)c2)cc1 10.1016/j.bmcl.2011.04.091
162665135 182301 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 380 6 2 3 4.3 O=C(O)CC(NC(=O)c1cccc(-c2ccc(Cl)cc2)c1)c1cccnc1 10.1021/acs.jmedchem.0c01020
CHEMBL4782840 182301 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 380 6 2 3 4.3 O=C(O)CC(NC(=O)c1cccc(-c2ccc(Cl)cc2)c1)c1cccnc1 10.1021/acs.jmedchem.0c01020
172463317 196804 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 379 5 2 2 5.2 Cc1cc(Cl)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
CHEMBL5432512 196804 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 379 5 2 2 5.2 Cc1cc(Cl)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
71456629 80973 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 530 6 2 4 6.4 NC(C(=O)NCc1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1)c1ccc(-c2ccc3cccnc3n2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153464 80973 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 530 6 2 4 6.4 NC(C(=O)NCc1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1)c1ccc(-c2ccc3cccnc3n2)cc1 10.1016/j.bmcl.2011.04.091
71456628 80972 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 599 6 2 4 7.2 O=C(NCc1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1)C(O)(c1ccc(-c2ccc3cccnc3n2)cc1)C(F)(F)F 10.1016/j.bmcl.2011.04.091
CHEMBL2153463 80972 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 599 6 2 4 7.2 O=C(NCc1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1)C(O)(c1ccc(-c2ccc3cccnc3n2)cc1)C(F)(F)F 10.1016/j.bmcl.2011.04.091
53358901 1125 None 13 Human Functional pIC50 = 7.5 7.5 3 2
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 458 7 1 5 5.1 O=C(NCc1onc(c1)c1ccc(c(c1)C(F)(F)F)F)CCCc1ccc2c(n1)nccc2 10.1016/j.bmcl.2011.04.091
5514 1125 None 13 Human Functional pIC50 = 7.5 7.5 3 2
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 458 7 1 5 5.1 O=C(NCc1onc(c1)c1ccc(c(c1)C(F)(F)F)F)CCCc1ccc2c(n1)nccc2 10.1016/j.bmcl.2011.04.091
CHEMBL2153581 1125 None 13 Human Functional pIC50 = 7.5 7.5 3 2
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 458 7 1 5 5.1 O=C(NCc1onc(c1)c1ccc(c(c1)C(F)(F)F)F)CCCc1ccc2c(n1)nccc2 10.1016/j.bmcl.2011.04.091
71462028 80960 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 433 7 1 3 5.7 O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2ccc(F)c(Cl)c2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153442 80960 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 433 7 1 3 5.7 O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2ccc(F)c(Cl)c2)cc1 10.1016/j.bmcl.2011.04.091
71462027 80958 None 0 Human Functional pIC50 = 7.4 7.4 2 3
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 415 7 1 3 5.6 O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2cccc(Cl)c2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153440 80958 None 0 Human Functional pIC50 = 7.4 7.4 2 3
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 415 7 1 3 5.6 O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2cccc(Cl)c2)cc1 10.1016/j.bmcl.2011.04.091
71456641 80991 None 0 Human Functional pIC50 = 7.4 7.4 1 3
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 426 6 0 5 6.2 Clc1cccc(-c2ccc(-c3nnc(CCCc4ccc5cccnc5n4)o3)cc2)c1 10.1016/j.bmcl.2011.04.091
CHEMBL2153586 80991 None 0 Human Functional pIC50 = 7.4 7.4 1 3
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 426 6 0 5 6.2 Clc1cccc(-c2ccc(-c3nnc(CCCc4ccc5cccnc5n4)o3)cc2)c1 10.1016/j.bmcl.2011.04.091
71456643 81003 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 432 7 0 6 5.3 Fc1ccc(-c2nnc(CCCCc3ccc4cccnc4n3)o2)cc1OC(F)(F)F 10.1016/j.bmcl.2011.04.091
CHEMBL2153598 81003 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 432 7 0 6 5.3 Fc1ccc(-c2nnc(CCCCc3ccc4cccnc4n3)o2)cc1OC(F)(F)F 10.1016/j.bmcl.2011.04.091
71451309 80961 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 467 7 1 3 6.1 O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2cccc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2011.04.091
CHEMBL2153443 80961 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 467 7 1 3 6.1 O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2cccc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2011.04.091
71451318 81001 None 0 Rat Functional pIC50 = 6.4 6.4 -2 2
Antagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 432 6 0 5 5.9 FC(F)(F)c1cc(-c2nnc(CCCCc3ccc4cccnc4n3)o2)ccc1Cl 10.1016/j.bmcl.2011.04.091
CHEMBL2153596 81001 None 0 Rat Functional pIC50 = 6.4 6.4 -2 2
Antagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 432 6 0 5 5.9 FC(F)(F)c1cc(-c2nnc(CCCCc3ccc4cccnc4n3)o2)ccc1Cl 10.1016/j.bmcl.2011.04.091
162664232 182185 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 365 5 2 2 4.9 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)cc2)c1 10.1021/acs.jmedchem.3c00552
CHEMBL4781545 182185 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 365 5 2 2 4.9 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)cc2)c1 10.1021/acs.jmedchem.3c00552
71462033 80978 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 469 7 1 5 4.9 O=C(CCCc1ccc2cccnc2n1)NCc1cnc(-c2ccc(F)c(C(F)(F)F)c2)nc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153469 80978 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 469 7 1 5 4.9 O=C(CCCc1ccc2cccnc2n1)NCc1cnc(-c2ccc(F)c(C(F)(F)F)c2)nc1 10.1016/j.bmcl.2011.04.091
71454858 80966 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 465 8 1 4 5.8 O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2cccc(OC(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153448 80966 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 465 8 1 4 5.8 O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2cccc(OC(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
162658251 181125 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 464 7 3 4 5.0 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)c(OC3CCCNC3)c2)c1 10.1021/acs.jmedchem.0c01020
CHEMBL4759141 181125 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 464 7 3 4 5.0 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)c(OC3CCCNC3)c2)c1 10.1021/acs.jmedchem.0c01020
172446384 195262 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 651 12 3 10 4.3 Cc1cc(CN2CCN(CCNC3C=CC([N+](=O)[O-])c4nonc43)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
CHEMBL5399663 195262 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 651 12 3 10 4.3 Cc1cc(CN2CCN(CCNC3C=CC([N+](=O)[O-])c4nonc43)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
172468500 196567 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 457 7 2 4 4.3 Cc1cc(CN2CCN(C)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
CHEMBL5426854 196567 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 457 7 2 4 4.3 Cc1cc(CN2CCN(C)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
172443620 195440 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 418 9 3 4 4.3 Cc1cc(OCCCN)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
CHEMBL5403855 195440 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 418 9 3 4 4.3 Cc1cc(OCCCN)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
172457829 196354 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 446 11 3 4 5.0 Cc1cc(OCCCCCN)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
CHEMBL5422075 196354 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 446 11 3 4 5.0 Cc1cc(OCCCCCN)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
71454857 80962 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 409 8 1 3 5.5 CCc1cccc(-c2ccc(CNC(=O)CCCc3ccc4cccnc4n3)cc2)c1 10.1016/j.bmcl.2011.04.091
CHEMBL2153444 80962 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 409 8 1 3 5.5 CCc1cccc(-c2ccc(CNC(=O)CCCc3ccc4cccnc4n3)cc2)c1 10.1016/j.bmcl.2011.04.091
71449520 80984 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 406 7 1 5 4.6 O=C(CCCc1ccc2cccnc2n1)NCc1cc(-c2cccc(Cl)c2)no1 10.1016/j.bmcl.2011.04.091
CHEMBL2153579 80984 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 406 7 1 5 4.6 O=C(CCCc1ccc2cccnc2n1)NCc1cc(-c2cccc(Cl)c2)no1 10.1016/j.bmcl.2011.04.091
71456641 80991 None 0 Rat Functional pIC50 = 7.2 7.2 -1 3
Antagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 426 6 0 5 6.2 Clc1cccc(-c2ccc(-c3nnc(CCCc4ccc5cccnc5n4)o3)cc2)c1 10.1016/j.bmcl.2011.04.091
CHEMBL2153586 80991 None 0 Rat Functional pIC50 = 7.2 7.2 -1 3
Antagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 426 6 0 5 6.2 Clc1cccc(-c2ccc(-c3nnc(CCCc4ccc5cccnc5n4)o3)cc2)c1 10.1016/j.bmcl.2011.04.091
53358775 80970 None 23 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 529 6 1 3 7.5 C[C@H](NC(=O)Cc1ccc(-c2ccc3cccnc3n2)cc1)c1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153461 80970 None 23 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 529 6 1 3 7.5 C[C@H](NC(=O)Cc1ccc(-c2ccc3cccnc3n2)cc1)c1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
53358900 80957 None 1 Rat Functional pIC50 = 8.2 8.2 4 2
Antagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 395 7 1 3 5.2 Cc1cccc(-c2ccc(CNC(=O)CCCc3ccc4cccnc4n3)cc2)c1 10.1016/j.bmcl.2011.04.091
CHEMBL2153439 80957 None 1 Rat Functional pIC50 = 8.2 8.2 4 2
Antagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 395 7 1 3 5.2 Cc1cccc(-c2ccc(CNC(=O)CCCc3ccc4cccnc4n3)cc2)c1 10.1016/j.bmcl.2011.04.091
71454869 80987 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 422 7 1 5 5.0 O=C(CCCc1ccc2cccnc2n1)NCc1csc(-c2cccc(Cl)c2)n1 10.1016/j.bmcl.2011.04.091
CHEMBL2153582 80987 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 422 7 1 5 5.0 O=C(CCCc1ccc2cccnc2n1)NCc1csc(-c2cccc(Cl)c2)n1 10.1016/j.bmcl.2011.04.091
71453125 80981 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 469 7 1 5 4.9 O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2ccc(F)c(C(F)(F)F)c2)nn1 10.1016/j.bmcl.2011.04.091
CHEMBL2153471 80981 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 469 7 1 5 4.9 O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2ccc(F)c(C(F)(F)F)c2)nn1 10.1016/j.bmcl.2011.04.091
71462031 80969 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 515 6 1 3 7.0 O=C(Cc1ccc(-c2ccc3cccnc3n2)cc1)NCc1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
CHEMBL2153460 80969 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 515 6 1 3 7.0 O=C(Cc1ccc(-c2ccc3cccnc3n2)cc1)NCc1ccc(-c2ccc(F)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2011.04.091
162659507 181481 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 482 7 3 4 5.2 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)c(O[C@@H]3CCCNC3)c2F)c1 10.1021/acs.jmedchem.0c01020
CHEMBL4763307 181481 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 482 7 3 4 5.2 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)c(O[C@@H]3CCCNC3)c2F)c1 10.1021/acs.jmedchem.0c01020
71449505 80955 None 0 Human Functional pIC50 = 6.1 6.1 3 2
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 475 8 1 5 5.0 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)CCCc2ccc3cccnc3n2)c(F)c1 10.1016/j.bmcl.2011.04.091
CHEMBL2153436 80955 None 0 Human Functional pIC50 = 6.1 6.1 3 2
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 475 8 1 5 5.0 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)CCCc2ccc3cccnc3n2)c(F)c1 10.1016/j.bmcl.2011.04.091
10519 2813 None 27 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 10.1021/acs.jmedchem.3c00552
138811017 2813 None 27 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL4790324 2813 None 27 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 10.1021/acs.jmedchem.3c00552
154585554 180465 None 9 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 518 7 3 4 5.4 O=C(O)Cc1cc(F)ccc1NC(=O)c1cccc(-c2cc(O[C@@H]3CCCNC3)c(Cl)cc2F)c1F 10.1021/acs.jmedchem.0c01020
CHEMBL4751488 180465 None 9 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 518 7 3 4 5.4 O=C(O)Cc1cc(F)ccc1NC(=O)c1cccc(-c2cc(O[C@@H]3CCCNC3)c(Cl)cc2F)c1F 10.1021/acs.jmedchem.0c01020
71453138 80986 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 424 7 1 5 4.7 O=C(CCCc1ccc2cccnc2n1)NCc1cc(-c2ccc(F)c(Cl)c2)no1 10.1016/j.bmcl.2011.04.091
CHEMBL2153580 80986 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
ChEMBL 424 7 1 5 4.7 O=C(CCCc1ccc2cccnc2n1)NCc1cc(-c2ccc(F)c(Cl)c2)no1 10.1016/j.bmcl.2011.04.091
162657186 180951 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 500 7 3 4 5.3 O=C(O)Cc1cc(F)ccc1NC(=O)c1cccc(-c2cc(O[C@@H]3CCCNC3)c(Cl)cc2F)c1 10.1021/acs.jmedchem.0c01020
CHEMBL4757124 180951 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 500 7 3 4 5.3 O=C(O)Cc1cc(F)ccc1NC(=O)c1cccc(-c2cc(O[C@@H]3CCCNC3)c(Cl)cc2F)c1 10.1021/acs.jmedchem.0c01020
162652581 180570 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 500 7 3 4 5.3 O=C(O)Cc1cc(F)ccc1NC(=O)c1cccc(-c2ccc(Cl)c(O[C@@H]3CCCNC3)c2F)c1 10.1021/acs.jmedchem.0c01020
CHEMBL4752851 180570 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assayAntagonist activity at human SUCNR1 expressed in human CHEM1 cells incubated for 60 mins in presence of [35S]GTPgammaS by scintillation proximity assay
ChEMBL 500 7 3 4 5.3 O=C(O)Cc1cc(F)ccc1NC(=O)c1cccc(-c2ccc(Cl)c(O[C@@H]3CCCNC3)c2F)c1 10.1021/acs.jmedchem.0c01020
172463491 196568 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 586 10 3 6 5.2 Cc1cc(CN2CCN(CCNC(=O)OC(C)(C)C)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
CHEMBL5426931 196568 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assayAntagonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of succinate response by cAMP assay
ChEMBL 586 10 3 6 5.2 Cc1cc(CN2CCN(CCNC(=O)OC(C)(C)C)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
1110 3698 None 67 Human Functional pEC50 = 8.3 8.3 -1 2
NoneNone
Drug Central 118 3 2 2 -0.1 OC(=O)CCC(=O)O None
21952380 3698 None 67 Human Functional pEC50 = 8.3 8.3 -1 2
NoneNone
Drug Central 118 3 2 2 -0.1 OC(=O)CCC(=O)O None
2487 3698 None 67 Human Functional pEC50 = 8.3 8.3 -1 2
NoneNone
Drug Central 118 3 2 2 -0.1 OC(=O)CCC(=O)O None
3637 3698 None 67 Human Functional pEC50 = 8.3 8.3 -1 2
NoneNone
Drug Central 118 3 2 2 -0.1 OC(=O)CCC(=O)O None
CHEMBL576 3698 None 67 Human Functional pEC50 = 8.3 8.3 -1 2
NoneNone
Drug Central 118 3 2 2 -0.1 OC(=O)CCC(=O)O None
DB00139 3698 None 67 Human Functional pEC50 = 8.3 8.3 -1 2
NoneNone
Drug Central 118 3 2 2 -0.1 OC(=O)CCC(=O)O None
10296 1068 None 0 Human Functional pEC50 = 7.6 7.6 - 1
IP<sub>3</sub> accumulation, E<sub>max</sub>=61%IP<sub>3</sub> accumulation, E<sub>max</sub>=61%
Guide to Pharmacology 396 7 1 7 -0.4 [O-]C(=O)C[C@@H](C(=O)[O-])NC(=O)c1cccc(n1)c1ccc(cc1)OC(F)(F)F 29968758
137553167 1068 None 0 Human Functional pEC50 = 7.6 7.6 - 1
IP<sub>3</sub> accumulation, E<sub>max</sub>=61%IP<sub>3</sub> accumulation, E<sub>max</sub>=61%
Guide to Pharmacology 396 7 1 7 -0.4 [O-]C(=O)C[C@@H](C(=O)[O-])NC(=O)c1cccc(n1)c1ccc(cc1)OC(F)(F)F 29968758
10294 982 None 0 Human Functional pEC50 = 5.7 5.7 - 1
IP<sub>3</sub> accumulation, E<sub>max</sub>=75%IP<sub>3</sub> accumulation, E<sub>max</sub>=75%
Guide to Pharmacology 321 6 3 4 1.7 O=C(c1ccc(o1)c1ccc(cc1)F)N[C@H](C(=O)O)CC(=O)O 29157600
41023370 982 None 0 Human Functional pEC50 = 5.7 5.7 - 1
IP<sub>3</sub> accumulation, E<sub>max</sub>=75%IP<sub>3</sub> accumulation, E<sub>max</sub>=75%
Guide to Pharmacology 321 6 3 4 1.7 O=C(c1ccc(o1)c1ccc(cc1)F)N[C@H](C(=O)O)CC(=O)O 29157600
2734802 1984 None 42 Human Functional pEC50 = 5.8 5.8 - 1
IP<sub>3</sub> accumulation, E<sub>max</sub>=93%IP<sub>3</sub> accumulation, E<sub>max</sub>=93%
Guide to Pharmacology 132 2 2 3 -1.1 OC(=O)[C@@H]1O[C@@H]1C(=O)O 29157600
9631 1984 None 42 Human Functional pEC50 = 5.8 5.8 - 1
IP<sub>3</sub> accumulation, E<sub>max</sub>=93%IP<sub>3</sub> accumulation, E<sub>max</sub>=93%
Guide to Pharmacology 132 2 2 3 -1.1 OC(=O)[C@@H]1O[C@@H]1C(=O)O 29157600
CHEMBL1741775 1984 None 42 Human Functional pEC50 = 5.8 5.8 - 1
IP<sub>3</sub> accumulation, E<sub>max</sub>=93%IP<sub>3</sub> accumulation, E<sub>max</sub>=93%
Guide to Pharmacology 132 2 2 3 -1.1 OC(=O)[C@@H]1O[C@@H]1C(=O)O 29157600
487 2512 None 0 Human Functional pEC50 = 3.6 3.6 - 1
UnclassifiedUnclassified
Guide to Pharmacology 118 2 2 2 -0.2 CC(C(=O)O)C(=O)O 15141213
9633 2512 None 0 Human Functional pEC50 = 3.6 3.6 - 1
UnclassifiedUnclassified
Guide to Pharmacology 118 2 2 2 -0.2 CC(C(=O)O)C(=O)O 15141213
CHEMBL1232416 2512 None 0 Human Functional pEC50 = 3.6 3.6 - 1
UnclassifiedUnclassified
Guide to Pharmacology 118 2 2 2 -0.2 CC(C(=O)O)C(=O)O 15141213
DB04183 2512 None 0 Human Functional pEC50 = 3.6 3.6 - 1
UnclassifiedUnclassified
Guide to Pharmacology 118 2 2 2 -0.2 CC(C(=O)O)C(=O)O 15141213
487 2512 None 0 Human Functional pEC50 = 3.8 3.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 118 2 2 2 -0.2 CC(C(=O)O)C(=O)O 28160606
9633 2512 None 0 Human Functional pEC50 = 3.8 3.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 118 2 2 2 -0.2 CC(C(=O)O)C(=O)O 28160606
CHEMBL1232416 2512 None 0 Human Functional pEC50 = 3.8 3.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 118 2 2 2 -0.2 CC(C(=O)O)C(=O)O 28160606
DB04183 2512 None 0 Human Functional pEC50 = 3.8 3.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 118 2 2 2 -0.2 CC(C(=O)O)C(=O)O 28160606
1110 3698 None 67 Human Functional pEC50 = 3.9 3.9 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 118 3 2 2 -0.1 OC(=O)CCC(=O)O 15141213
1110 3698 None 67 Human Functional pEC50 = 3.9 3.9 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 118 3 2 2 -0.1 OC(=O)CCC(=O)O 23396314
21952380 3698 None 67 Human Functional pEC50 = 3.9 3.9 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 118 3 2 2 -0.1 OC(=O)CCC(=O)O 15141213
21952380 3698 None 67 Human Functional pEC50 = 3.9 3.9 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 118 3 2 2 -0.1 OC(=O)CCC(=O)O 23396314
2487 3698 None 67 Human Functional pEC50 = 3.9 3.9 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 118 3 2 2 -0.1 OC(=O)CCC(=O)O 15141213
2487 3698 None 67 Human Functional pEC50 = 3.9 3.9 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 118 3 2 2 -0.1 OC(=O)CCC(=O)O 23396314
3637 3698 None 67 Human Functional pEC50 = 3.9 3.9 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 118 3 2 2 -0.1 OC(=O)CCC(=O)O 15141213
3637 3698 None 67 Human Functional pEC50 = 3.9 3.9 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 118 3 2 2 -0.1 OC(=O)CCC(=O)O 23396314
CHEMBL576 3698 None 67 Human Functional pEC50 = 3.9 3.9 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 118 3 2 2 -0.1 OC(=O)CCC(=O)O 15141213
CHEMBL576 3698 None 67 Human Functional pEC50 = 3.9 3.9 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 118 3 2 2 -0.1 OC(=O)CCC(=O)O 23396314
DB00139 3698 None 67 Human Functional pEC50 = 3.9 3.9 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 118 3 2 2 -0.1 OC(=O)CCC(=O)O 15141213
DB00139 3698 None 67 Human Functional pEC50 = 3.9 3.9 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 118 3 2 2 -0.1 OC(=O)CCC(=O)O 23396314
444266 2455 None 52 Human Functional pEC50 = 4.1 4.1 -2818 2
UnclassifiedUnclassified
Guide to Pharmacology 116 2 2 2 -0.3 OC(=O)/C=C\C(=O)O 15141213
444266 2455 None 52 Human Functional pEC50 = 4.1 4.1 -2818 2
UnclassifiedUnclassified
Guide to Pharmacology 116 2 2 2 -0.3 OC(=O)/C=C\C(=O)O 26386312
444266 2455 None 52 Human Functional pEC50 = 4.1 4.1 -2818 2
UnclassifiedUnclassified
Guide to Pharmacology 116 2 2 2 -0.3 OC(=O)/C=C\C(=O)O 28160606
9630 2455 None 52 Human Functional pEC50 = 4.1 4.1 -2818 2
UnclassifiedUnclassified
Guide to Pharmacology 116 2 2 2 -0.3 OC(=O)/C=C\C(=O)O 15141213
9630 2455 None 52 Human Functional pEC50 = 4.1 4.1 -2818 2
UnclassifiedUnclassified
Guide to Pharmacology 116 2 2 2 -0.3 OC(=O)/C=C\C(=O)O 26386312
9630 2455 None 52 Human Functional pEC50 = 4.1 4.1 -2818 2
UnclassifiedUnclassified
Guide to Pharmacology 116 2 2 2 -0.3 OC(=O)/C=C\C(=O)O 28160606
CHEMBL539648 2455 None 52 Human Functional pEC50 = 4.1 4.1 -2818 2
UnclassifiedUnclassified
Guide to Pharmacology 116 2 2 2 -0.3 OC(=O)/C=C\C(=O)O 15141213
CHEMBL539648 2455 None 52 Human Functional pEC50 = 4.1 4.1 -2818 2
UnclassifiedUnclassified
Guide to Pharmacology 116 2 2 2 -0.3 OC(=O)/C=C\C(=O)O 26386312
CHEMBL539648 2455 None 52 Human Functional pEC50 = 4.1 4.1 -2818 2
UnclassifiedUnclassified
Guide to Pharmacology 116 2 2 2 -0.3 OC(=O)/C=C\C(=O)O 28160606
DB04299 2455 None 52 Human Functional pEC50 = 4.1 4.1 -2818 2
UnclassifiedUnclassified
Guide to Pharmacology 116 2 2 2 -0.3 OC(=O)/C=C\C(=O)O 15141213
DB04299 2455 None 52 Human Functional pEC50 = 4.1 4.1 -2818 2
UnclassifiedUnclassified
Guide to Pharmacology 116 2 2 2 -0.3 OC(=O)/C=C\C(=O)O 26386312
DB04299 2455 None 52 Human Functional pEC50 = 4.1 4.1 -2818 2
UnclassifiedUnclassified
Guide to Pharmacology 116 2 2 2 -0.3 OC(=O)/C=C\C(=O)O 28160606
9634 3560 None 0 Human Functional pEC50 = 4.1 4.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 152 3 2 2 0.2 OC(=O)C[C@@H](C(=O)O)Cl 28160606
9793861 3560 None 0 Human Functional pEC50 = 4.1 4.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 152 3 2 2 0.2 OC(=O)C[C@@H](C(=O)O)Cl 28160606
726455 1983 None 0 Human Functional pEC50 = 4.3 4.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 130 2 2 2 -0.2 OC(=O)[C@@H]1C[C@@H]1C(=O)O 28160606
9632 1983 None 0 Human Functional pEC50 = 4.3 4.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 130 2 2 2 -0.2 OC(=O)[C@@H]1C[C@@H]1C(=O)O 28160606
2734802 1984 None 42 Human Functional pEC50 = 5.6 5.6 - 1
cAMP inhibition, E<sub>max</sub>=100%cAMP inhibition, E<sub>max</sub>=100%
Guide to Pharmacology 132 2 2 3 -1.1 OC(=O)[C@@H]1O[C@@H]1C(=O)O 28160606
9631 1984 None 42 Human Functional pEC50 = 5.6 5.6 - 1
cAMP inhibition, E<sub>max</sub>=100%cAMP inhibition, E<sub>max</sub>=100%
Guide to Pharmacology 132 2 2 3 -1.1 OC(=O)[C@@H]1O[C@@H]1C(=O)O 28160606
CHEMBL1741775 1984 None 42 Human Functional pEC50 = 5.6 5.6 - 1
cAMP inhibition, E<sub>max</sub>=100%cAMP inhibition, E<sub>max</sub>=100%
Guide to Pharmacology 132 2 2 3 -1.1 OC(=O)[C@@H]1O[C@@H]1C(=O)O 28160606
5515 1138 None 0 Human Functional pIC50 = 6.7 6.7 - 1
UnclassifiedUnclassified
Guide to Pharmacology 533 11 1 7 5.7 O=C(NCCCCc1nnc(o1)c1ccc(c(c1)Cl)OC(F)(F)F)CCCc1ccc2c(n1)nccc2 21571530
73755126 1138 None 0 Human Functional pIC50 = 6.7 6.7 - 1
UnclassifiedUnclassified
Guide to Pharmacology 533 11 1 7 5.7 O=C(NCCCCc1nnc(o1)c1ccc(c(c1)Cl)OC(F)(F)F)CCCc1ccc2c(n1)nccc2 21571530
53358901 1125 None 13 Rat Functional pIC50 = 6.9 6.9 -3 2
UnclassifiedUnclassified
Guide to Pharmacology 458 7 1 5 5.1 O=C(NCc1onc(c1)c1ccc(c(c1)C(F)(F)F)F)CCCc1ccc2c(n1)nccc2 21571530
5514 1125 None 13 Rat Functional pIC50 = 6.9 6.9 -3 2
UnclassifiedUnclassified
Guide to Pharmacology 458 7 1 5 5.1 O=C(NCc1onc(c1)c1ccc(c(c1)C(F)(F)F)F)CCCc1ccc2c(n1)nccc2 21571530
CHEMBL2153581 1125 None 13 Rat Functional pIC50 = 6.9 6.9 -3 2
UnclassifiedUnclassified
Guide to Pharmacology 458 7 1 5 5.1 O=C(NCc1onc(c1)c1ccc(c(c1)C(F)(F)F)F)CCCc1ccc2c(n1)nccc2 21571530
53358901 1125 None 13 Human Functional pIC50 = 7.5 7.5 3 2
UnclassifiedUnclassified
Guide to Pharmacology 458 7 1 5 5.1 O=C(NCc1onc(c1)c1ccc(c(c1)C(F)(F)F)F)CCCc1ccc2c(n1)nccc2 21571530
5514 1125 None 13 Human Functional pIC50 = 7.5 7.5 3 2
UnclassifiedUnclassified
Guide to Pharmacology 458 7 1 5 5.1 O=C(NCc1onc(c1)c1ccc(c(c1)C(F)(F)F)F)CCCc1ccc2c(n1)nccc2 21571530
CHEMBL2153581 1125 None 13 Human Functional pIC50 = 7.5 7.5 3 2
UnclassifiedUnclassified
Guide to Pharmacology 458 7 1 5 5.1 O=C(NCc1onc(c1)c1ccc(c(c1)C(F)(F)F)F)CCCc1ccc2c(n1)nccc2 21571530


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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type		 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
172470467 197125 None 0 Mouse Binding pKd = 5.9 5.9 1 2
Binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assay
ChEMBL 567 15 4 11 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL5439297 197125 None 0 Mouse Binding pKd = 5.9 5.9 1 2
Binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assay
ChEMBL 567 15 4 11 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
171378461 197076 None 0 Mouse Binding pKd = 5.9 5.9 -1 2
Binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assay
ChEMBL 624 19 5 12 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL5438140 197076 None 0 Mouse Binding pKd = 5.9 5.9 -1 2
Binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assay
ChEMBL 624 19 5 12 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
171378461 197076 None 0 Mouse Binding pKd = 5.8 5.8 -1 2
Binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 10 mins by BRET assayBinding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 10 mins by BRET assay
ChEMBL 624 19 5 12 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL5438140 197076 None 0 Mouse Binding pKd = 5.8 5.8 -1 2
Binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 10 mins by BRET assayBinding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 10 mins by BRET assay
ChEMBL 624 19 5 12 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
172470467 197125 None 0 Human Binding pKd = 5.8 5.8 -1 2
Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assay
ChEMBL 567 15 4 11 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL5439297 197125 None 0 Human Binding pKd = 5.8 5.8 -1 2
Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assay
ChEMBL 567 15 4 11 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
172446384 195262 None 0 Human Binding pKd = 6.5 6.5 - 1
Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 5 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 5 mins by NanoBRET assay
ChEMBL 651 12 3 10 4.3 Cc1cc(CN2CCN(CCNC3C=CC([N+](=O)[O-])c4nonc43)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
CHEMBL5399663 195262 None 0 Human Binding pKd = 6.5 6.5 - 1
Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 5 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 5 mins by NanoBRET assay
ChEMBL 651 12 3 10 4.3 Cc1cc(CN2CCN(CCNC3C=CC([N+](=O)[O-])c4nonc43)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
172446384 195262 None 0 Human Binding pKd = 6.3 6.3 - 1
Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 15 mins by BRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 15 mins by BRET assay
ChEMBL 651 12 3 10 4.3 Cc1cc(CN2CCN(CCNC3C=CC([N+](=O)[O-])c4nonc43)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
CHEMBL5399663 195262 None 0 Human Binding pKd = 6.3 6.3 - 1
Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 15 mins by BRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 15 mins by BRET assay
ChEMBL 651 12 3 10 4.3 Cc1cc(CN2CCN(CCNC3C=CC([N+](=O)[O-])c4nonc43)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
171378461 197076 None 0 Human Binding pKd = 6.2 6.2 1 2
Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 15 mins by BRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 15 mins by BRET assay
ChEMBL 624 19 5 12 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL5438140 197076 None 0 Human Binding pKd = 6.2 6.2 1 2
Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 15 mins by BRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 15 mins by BRET assay
ChEMBL 624 19 5 12 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
171378461 197076 None 0 Human Binding pKd = 6 6.0 1 2
Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assay
ChEMBL 624 19 5 12 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL5438140 197076 None 0 Human Binding pKd = 6 6.0 1 2
Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assay
ChEMBL 624 19 5 12 3.7 O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O 10.1021/acs.jmedchem.3c00552
142429204 194991 None 0 Human Binding pKi = 5.9 5.9 - 1
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 453 7 1 4 6.9 O=C(O)CCc1cccc(Oc2ccc(Oc3cccc4cnccc34)cc2C(F)(F)F)c1 10.1021/acs.jmedchem.3c00552
CHEMBL5394500 194991 None 0 Human Binding pKi = 5.9 5.9 - 1
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 453 7 1 4 6.9 O=C(O)CCc1cccc(Oc2ccc(Oc3cccc4cnccc34)cc2C(F)(F)F)c1 10.1021/acs.jmedchem.3c00552
162664232 182185 None 0 Human Binding pKi = 7.8 7.8 - 1
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 365 5 2 2 4.9 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)cc2)c1 10.1021/acs.jmedchem.3c00552
CHEMBL4781545 182185 None 0 Human Binding pKi = 7.8 7.8 - 1
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 365 5 2 2 4.9 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)cc2)c1 10.1021/acs.jmedchem.3c00552
137553168 196727 None 3 Mouse Binding pKi = 5.8 5.8 -5 2
Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 398 7 3 5 2.3 O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(OC(F)(F)F)cc2)n1)C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL5430997 196727 None 3 Mouse Binding pKi = 5.8 5.8 -5 2
Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 398 7 3 5 2.3 O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(OC(F)(F)F)cc2)n1)C(=O)O 10.1021/acs.jmedchem.3c00552
162664232 182185 None 0 Human Binding pKi = 7.6 7.6 - 1
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 365 5 2 2 4.9 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)cc2)c1 10.1021/acs.jmedchem.3c00552
CHEMBL4781545 182185 None 0 Human Binding pKi = 7.6 7.6 - 1
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 365 5 2 2 4.9 O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)cc2)c1 10.1021/acs.jmedchem.3c00552
137553168 196727 None 3 Human Binding pKi = 6.6 6.6 5 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 398 7 3 5 2.3 O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(OC(F)(F)F)cc2)n1)C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL5430997 196727 None 3 Human Binding pKi = 6.6 6.6 5 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 398 7 3 5 2.3 O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(OC(F)(F)F)cc2)n1)C(=O)O 10.1021/acs.jmedchem.3c00552
172463317 196804 None 0 Human Binding pKi = 7.5 7.5 - 1
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 379 5 2 2 5.2 Cc1cc(Cl)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
CHEMBL5432512 196804 None 0 Human Binding pKi = 7.5 7.5 - 1
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 379 5 2 2 5.2 Cc1cc(Cl)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
137553168 196727 None 3 Human Binding pKi = 6.5 6.5 5 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 398 7 3 5 2.3 O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(OC(F)(F)F)cc2)n1)C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL5430997 196727 None 3 Human Binding pKi = 6.5 6.5 5 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 398 7 3 5 2.3 O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(OC(F)(F)F)cc2)n1)C(=O)O 10.1021/acs.jmedchem.3c00552
10519 2813 None 27 Human Binding pKi = 7.4 7.4 218 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 10.1021/acs.jmedchem.3c00552
138811017 2813 None 27 Human Binding pKi = 7.4 7.4 218 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL4790324 2813 None 27 Human Binding pKi = 7.4 7.4 218 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 10.1021/acs.jmedchem.3c00552
172468500 196567 None 0 Human Binding pKi = 7.4 7.4 - 1
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 457 7 2 4 4.3 Cc1cc(CN2CCN(C)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
CHEMBL5426854 196567 None 0 Human Binding pKi = 7.4 7.4 - 1
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 457 7 2 4 4.3 Cc1cc(CN2CCN(C)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
172463317 196804 None 0 Human Binding pKi = 7.4 7.4 - 1
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 379 5 2 2 5.2 Cc1cc(Cl)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
CHEMBL5432512 196804 None 0 Human Binding pKi = 7.4 7.4 - 1
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 379 5 2 2 5.2 Cc1cc(Cl)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
2734802 1984 None 42 Mouse Binding pKi = 4.4 4.4 1 2
Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 132 2 2 3 -1.1 OC(=O)[C@@H]1O[C@@H]1C(=O)O 10.1021/acs.jmedchem.3c00552
9631 1984 None 42 Mouse Binding pKi = 4.4 4.4 1 2
Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 132 2 2 3 -1.1 OC(=O)[C@@H]1O[C@@H]1C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL1741775 1984 None 42 Mouse Binding pKi = 4.4 4.4 1 2
Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 132 2 2 3 -1.1 OC(=O)[C@@H]1O[C@@H]1C(=O)O 10.1021/acs.jmedchem.3c00552
172468500 196567 None 0 Human Binding pKi = 7.3 7.3 - 1
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 457 7 2 4 4.3 Cc1cc(CN2CCN(C)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
CHEMBL5426854 196567 None 0 Human Binding pKi = 7.3 7.3 - 1
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 457 7 2 4 4.3 Cc1cc(CN2CCN(C)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 10.1021/acs.jmedchem.3c00552
172447933 195873 None 0 Human Binding pKi = 6.3 6.3 1 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 418 13 4 6 2.5 NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5412414 195873 None 0 Human Binding pKi = 6.3 6.3 1 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 418 13 4 6 2.5 NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172447933 195873 None 0 Human Binding pKi = 6.3 6.3 1 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 418 13 4 6 2.5 NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5412414 195873 None 0 Human Binding pKi = 6.3 6.3 1 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 418 13 4 6 2.5 NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
169205458 196510 None 0 Human Binding pKi = 6.3 6.3 1 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 347 8 3 5 2.0 CCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5425639 196510 None 0 Human Binding pKi = 6.3 6.3 1 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 347 8 3 5 2.0 CCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
172447933 195873 None 0 Mouse Binding pKi = 6.2 6.2 -1 2
Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 418 13 4 6 2.5 NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5412414 195873 None 0 Mouse Binding pKi = 6.2 6.2 -1 2
Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 418 13 4 6 2.5 NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
169205458 196510 None 0 Mouse Binding pKi = 6.2 6.2 -1 2
Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 347 8 3 5 2.0 CCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5425639 196510 None 0 Mouse Binding pKi = 6.2 6.2 -1 2
Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 347 8 3 5 2.0 CCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
10519 2813 None 27 Human Binding pKi = 7.1 7.1 218 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 10.1021/acs.jmedchem.3c00552
138811017 2813 None 27 Human Binding pKi = 7.1 7.1 218 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL4790324 2813 None 27 Human Binding pKi = 7.1 7.1 218 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 10.1021/acs.jmedchem.3c00552
169205458 196510 None 0 Human Binding pKi = 6.1 6.1 1 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 347 8 3 5 2.0 CCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
CHEMBL5425639 196510 None 0 Human Binding pKi = 6.1 6.1 1 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 347 8 3 5 2.0 CCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 10.1021/acs.jmedchem.3c00552
142429204 194991 None 0 Human Binding pKi = 5.1 5.1 - 1
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 453 7 1 4 6.9 O=C(O)CCc1cccc(Oc2ccc(Oc3cccc4cnccc34)cc2C(F)(F)F)c1 10.1021/acs.jmedchem.3c00552
CHEMBL5394500 194991 None 0 Human Binding pKi = 5.1 5.1 - 1
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 453 7 1 4 6.9 O=C(O)CCc1cccc(Oc2ccc(Oc3cccc4cnccc34)cc2C(F)(F)F)c1 10.1021/acs.jmedchem.3c00552
10519 2813 None 27 Mouse Binding pKi = 5.1 5.1 -218 2
Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 10.1021/acs.jmedchem.3c00552
138811017 2813 None 27 Mouse Binding pKi = 5.1 5.1 -218 2
Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL4790324 2813 None 27 Mouse Binding pKi = 5.1 5.1 -218 2
Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 10.1021/acs.jmedchem.3c00552
2734802 1984 None 42 Human Binding pKi = 4.1 4.1 -1 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 132 2 2 3 -1.1 OC(=O)[C@@H]1O[C@@H]1C(=O)O 10.1021/acs.jmedchem.3c00552
9631 1984 None 42 Human Binding pKi = 4.1 4.1 -1 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 132 2 2 3 -1.1 OC(=O)[C@@H]1O[C@@H]1C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL1741775 1984 None 42 Human Binding pKi = 4.1 4.1 -1 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay
ChEMBL 132 2 2 3 -1.1 OC(=O)[C@@H]1O[C@@H]1C(=O)O 10.1021/acs.jmedchem.3c00552
2734802 1984 None 42 Human Binding pKi = 4.1 4.1 -1 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 132 2 2 3 -1.1 OC(=O)[C@@H]1O[C@@H]1C(=O)O 10.1021/acs.jmedchem.3c00552
9631 1984 None 42 Human Binding pKi = 4.1 4.1 -1 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 132 2 2 3 -1.1 OC(=O)[C@@H]1O[C@@H]1C(=O)O 10.1021/acs.jmedchem.3c00552
CHEMBL1741775 1984 None 42 Human Binding pKi = 4.1 4.1 -1 2
Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay
ChEMBL 132 2 2 3 -1.1 OC(=O)[C@@H]1O[C@@H]1C(=O)O 10.1021/acs.jmedchem.3c00552
10519 2813 None 27 Human Binding pKd = 7.5 7.5 218 2
Dissociation constant for [<sup>3</sup>H]-labelled NF-56-EJ40 binding to human SUCNR1 determined in a radioligand binding assay.Dissociation constant for [<sup>3</sup>H]-labelled NF-56-EJ40 binding to human SUCNR1 determined in a radioligand binding assay.
Guide to Pharmacology 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 31645725
138811017 2813 None 27 Human Binding pKd = 7.5 7.5 218 2
Dissociation constant for [<sup>3</sup>H]-labelled NF-56-EJ40 binding to human SUCNR1 determined in a radioligand binding assay.Dissociation constant for [<sup>3</sup>H]-labelled NF-56-EJ40 binding to human SUCNR1 determined in a radioligand binding assay.
Guide to Pharmacology 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 31645725
CHEMBL4790324 2813 None 27 Human Binding pKd = 7.5 7.5 218 2
Dissociation constant for [<sup>3</sup>H]-labelled NF-56-EJ40 binding to human SUCNR1 determined in a radioligand binding assay.Dissociation constant for [<sup>3</sup>H]-labelled NF-56-EJ40 binding to human SUCNR1 determined in a radioligand binding assay.
Guide to Pharmacology 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 31645725
10519 2813 None 27 Human Binding pKi = 7.8 7.8 218 2
UnclassifiedUnclassified
Guide to Pharmacology 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 31645725
138811017 2813 None 27 Human Binding pKi = 7.8 7.8 218 2
UnclassifiedUnclassified
Guide to Pharmacology 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 31645725
CHEMBL4790324 2813 None 27 Human Binding pKi = 7.8 7.8 218 2
UnclassifiedUnclassified
Guide to Pharmacology 443 7 2 4 4.0 CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O 31645725