Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 154634333 | 185321 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | Agonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as dynamic mass redistribution response by DMR assayAgonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as dynamic mass redistribution response by DMR assay |
ChEMBL | 352 | 2 | 2 | 6 | 2.4 | O=C(O)c1cc2c3ccccc3c3cc(C(=O)O)c(=O)oc3c2oc1=O | 10.1021/acs.jmedchem.0c01624 | ||
| CHEMBL4857772 | 185321 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | Agonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as dynamic mass redistribution response by DMR assayAgonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as dynamic mass redistribution response by DMR assay |
ChEMBL | 352 | 2 | 2 | 6 | 2.4 | O=C(O)c1cc2c3ccccc3c3cc(C(=O)O)c(=O)oc3c2oc1=O | 10.1021/acs.jmedchem.0c01624 | ||
| 326869 | 112874 | None | 2 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as dynamic mass redistribution response by DMR assayAgonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as dynamic mass redistribution response by DMR assay |
ChEMBL | 314 | 2 | 4 | 4 | 1.1 | Cc1c2[nH]c(C(=O)O)cc(=O)c2cc2c(=O)cc(C(=O)O)[nH]c12 | 10.1021/acs.jmedchem.0c01624 | ||
| CHEMBL3306990 | 112874 | None | 2 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as dynamic mass redistribution response by DMR assayAgonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as dynamic mass redistribution response by DMR assay |
ChEMBL | 314 | 2 | 4 | 4 | 1.1 | Cc1c2[nH]c(C(=O)O)cc(=O)c2cc2c(=O)cc(C(=O)O)[nH]c12 | 10.1021/acs.jmedchem.0c01624 | ||
| 164610101 | 184981 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonist activity at human GPR35 receptor expressed in HT-29 cells assessed as dynamic mass redistribution response by DMR assayAgonist activity at human GPR35 receptor expressed in HT-29 cells assessed as dynamic mass redistribution response by DMR assay |
ChEMBL | 342 | 4 | 2 | 6 | 2.5 | COc1cc(C(=O)O)nc2c(C)c3nc(C(=O)O)cc(OC)c3cc12 | 10.1021/acs.jmedchem.0c01624 | ||
| CHEMBL4852667 | 184981 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonist activity at human GPR35 receptor expressed in HT-29 cells assessed as dynamic mass redistribution response by DMR assayAgonist activity at human GPR35 receptor expressed in HT-29 cells assessed as dynamic mass redistribution response by DMR assay |
ChEMBL | 342 | 4 | 2 | 6 | 2.5 | COc1cc(C(=O)O)nc2c(C)c3nc(C(=O)O)cc(OC)c3cc12 | 10.1021/acs.jmedchem.0c01624 | ||
| 135399235 | 4134 | None | 41 | Mouse | Functional | pEC50 | = | 6 | 6.0 | -31 | 3 | Agonist activity at mouse GPR35 by beta-arrestin recruitment assayAgonist activity at mouse GPR35 by beta-arrestin recruitment assay |
ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmc.2023.117511 | ||
| 2919 | 4134 | None | 41 | Mouse | Functional | pEC50 | = | 6 | 6.0 | -31 | 3 | Agonist activity at mouse GPR35 by beta-arrestin recruitment assayAgonist activity at mouse GPR35 by beta-arrestin recruitment assay |
ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmc.2023.117511 | ||
| 5722 | 4134 | None | 41 | Mouse | Functional | pEC50 | = | 6 | 6.0 | -31 | 3 | Agonist activity at mouse GPR35 by beta-arrestin recruitment assayAgonist activity at mouse GPR35 by beta-arrestin recruitment assay |
ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmc.2023.117511 | ||
| CHEMBL28079 | 4134 | None | 41 | Mouse | Functional | pEC50 | = | 6 | 6.0 | -31 | 3 | Agonist activity at mouse GPR35 by beta-arrestin recruitment assayAgonist activity at mouse GPR35 by beta-arrestin recruitment assay |
ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmc.2023.117511 | ||
| 12138435 | 68079 | None | 26 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and GPR35-GA14-VP16 transcription factor fusion protein assessed as transcriptional activation after 5 hrs by tango beta-arrestin translocation reporter assayAgonist activity at GPR35 in human U20S cells expressing beta-lactamase and GPR35-GA14-VP16 transcription factor fusion protein assessed as transcriptional activation after 5 hrs by tango beta-arrestin translocation reporter assay |
ChEMBL | 329 | 1 | 0 | 4 | 4.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1 | 10.1021/jm200999f | ||
| CHEMBL1914576 | 68079 | None | 26 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and GPR35-GA14-VP16 transcription factor fusion protein assessed as transcriptional activation after 5 hrs by tango beta-arrestin translocation reporter assayAgonist activity at GPR35 in human U20S cells expressing beta-lactamase and GPR35-GA14-VP16 transcription factor fusion protein assessed as transcriptional activation after 5 hrs by tango beta-arrestin translocation reporter assay |
ChEMBL | 329 | 1 | 0 | 4 | 4.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1 | 10.1021/jm200999f | ||
| 70696510 | 75329 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assayAgonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assay |
ChEMBL | 296 | 1 | 1 | 3 | 4.1 | O=C(O)c1sc2c(Br)csc2c1Cl | 10.1016/j.bmcl.2012.04.057 | ||
| CHEMBL2037458 | 75329 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assayAgonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assay |
ChEMBL | 296 | 1 | 1 | 3 | 4.1 | O=C(O)c1sc2c(Br)csc2c1Cl | 10.1016/j.bmcl.2012.04.057 | ||
| 70682869 | 77410 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at GPR35 in human HT-29 cells measured after 10 mins by dynamic mass redistribution assayAgonist activity at GPR35 in human HT-29 cells measured after 10 mins by dynamic mass redistribution assay |
ChEMBL | 275 | 2 | 4 | 4 | 3.0 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1ccsc1 | 10.1021/ml300076u | ||
| CHEMBL2086422 | 77410 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at GPR35 in human HT-29 cells measured after 10 mins by dynamic mass redistribution assayAgonist activity at GPR35 in human HT-29 cells measured after 10 mins by dynamic mass redistribution assay |
ChEMBL | 275 | 2 | 4 | 4 | 3.0 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1ccsc1 | 10.1021/ml300076u | ||
| 5281605 | 208190 | None | 72 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assayAgonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay |
ChEMBL | 270 | 1 | 3 | 5 | 2.6 | O=c1cc(-c2ccccc2)oc2cc(O)c(O)c(O)c12 | 10.1021/ml2003058 | ||
| CHEMBL8260 | 208190 | None | 72 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assayAgonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay |
ChEMBL | 270 | 1 | 3 | 5 | 2.6 | O=c1cc(-c2ccccc2)oc2cc(O)c(O)c(O)c12 | 10.1021/ml2003058 | ||
| 172462775 | 196680 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -8 | 2 | Agonist activity at human GPR35 expressed in HEK293 cells co-expressing Galpha16 assessed as increase in calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at human GPR35 expressed in HEK293 cells co-expressing Galpha16 assessed as increase in calcium mobilization by Fluo-4 AM dye based fluorescence assay |
ChEMBL | 490 | 4 | 2 | 6 | 4.2 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CCCC2)c1Cl)C(=O)OC1CCCC1 | 10.1016/j.bmc.2023.117511 | ||
| CHEMBL5429740 | 196680 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -8 | 2 | Agonist activity at human GPR35 expressed in HEK293 cells co-expressing Galpha16 assessed as increase in calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at human GPR35 expressed in HEK293 cells co-expressing Galpha16 assessed as increase in calcium mobilization by Fluo-4 AM dye based fluorescence assay |
ChEMBL | 490 | 4 | 2 | 6 | 4.2 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CCCC2)c1Cl)C(=O)OC1CCCC1 | 10.1016/j.bmc.2023.117511 | ||
| 145950576 | 162974 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assayAgonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assay |
ChEMBL | 333 | 3 | 2 | 5 | 2.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccco1 | 10.1021/acsmedchemlett.7b00510 | ||
| CHEMBL4173352 | 162974 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assayAgonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assay |
ChEMBL | 333 | 3 | 2 | 5 | 2.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccco1 | 10.1021/acsmedchemlett.7b00510 | ||
| 70687103 | 77731 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at GPR35 in human HT-29 cells measured after 10 mins by dynamic mass redistribution assayAgonist activity at GPR35 in human HT-29 cells measured after 10 mins by dynamic mass redistribution assay |
ChEMBL | 337 | 2 | 4 | 3 | 4.3 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1cc(Cl)cc(Cl)c1 | 10.1021/ml300076u | ||
| CHEMBL2089222 | 77731 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at GPR35 in human HT-29 cells measured after 10 mins by dynamic mass redistribution assayAgonist activity at GPR35 in human HT-29 cells measured after 10 mins by dynamic mass redistribution assay |
ChEMBL | 337 | 2 | 4 | 3 | 4.3 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1cc(Cl)cc(Cl)c1 | 10.1021/ml300076u | ||
| 70687102 | 77730 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at human GPR35 expressed in U2OS cells coexpressing Gal4-VP16/beta-arrestin fusion protein after 5 hrs by tango beta-arrestin translocation reporter gene assayAgonist activity at human GPR35 expressed in U2OS cells coexpressing Gal4-VP16/beta-arrestin fusion protein after 5 hrs by tango beta-arrestin translocation reporter gene assay |
ChEMBL | 313 | 3 | 5 | 4 | 2.6 | O=C(O)c1ccc(-c2c(C(=O)O)[nH]c3cc(O)c(O)cc23)cc1 | 10.1021/ml300076u | ||
| CHEMBL2089221 | 77730 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at human GPR35 expressed in U2OS cells coexpressing Gal4-VP16/beta-arrestin fusion protein after 5 hrs by tango beta-arrestin translocation reporter gene assayAgonist activity at human GPR35 expressed in U2OS cells coexpressing Gal4-VP16/beta-arrestin fusion protein after 5 hrs by tango beta-arrestin translocation reporter gene assay |
ChEMBL | 313 | 3 | 5 | 4 | 2.6 | O=C(O)c1ccc(-c2c(C(=O)O)[nH]c3cc(O)c(O)cc23)cc1 | 10.1021/ml300076u | ||
| 5281855 | 205301 | None | 65 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assayAgonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay |
ChEMBL | 302 | 0 | 4 | 8 | 1.3 | O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23 | 10.1021/ml2003058 | ||
| CHEMBL6246 | 205301 | None | 65 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assayAgonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay |
ChEMBL | 302 | 0 | 4 | 8 | 1.3 | O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23 | 10.1021/ml2003058 | ||
| 53257379 | 68083 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at GPR35 in human HT-29 cells after 1 hr by dynamic mass redistribution assayAgonist activity at GPR35 in human HT-29 cells after 1 hr by dynamic mass redistribution assay |
ChEMBL | 363 | 1 | 0 | 4 | 5.0 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1Cl | 10.1021/jm200999f | ||
| CHEMBL1914580 | 68083 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at GPR35 in human HT-29 cells after 1 hr by dynamic mass redistribution assayAgonist activity at GPR35 in human HT-29 cells after 1 hr by dynamic mass redistribution assay |
ChEMBL | 363 | 1 | 0 | 4 | 5.0 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1Cl | 10.1021/jm200999f | ||
| 135403802 | 26539 | None | 39 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assayAgonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay |
ChEMBL | 300 | 0 | 4 | 6 | 1.3 | O=C1C=C2CC3(O)COc4c(ccc(O)c4O)C3=C2C=C1O | 10.1021/ml2003058 | ||
| CHEMBL1360563 | 26539 | None | 39 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assayAgonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay |
ChEMBL | 300 | 0 | 4 | 6 | 1.3 | O=C1C=C2CC3(O)COc4c(ccc(O)c4O)C3=C2C=C1O | 10.1021/ml2003058 | ||
| 411 | 2593 | None | 63 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -144 | 2 | Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assayAgonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay |
ChEMBL | 302 | 1 | 5 | 7 | 2.0 | Oc1ccc(c(c1)O)c1oc2cc(O)cc(c2c(=O)c1O)O | 10.1021/ml2003058 | ||
| 5281670 | 2593 | None | 63 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -144 | 2 | Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assayAgonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay |
ChEMBL | 302 | 1 | 5 | 7 | 2.0 | Oc1ccc(c(c1)O)c1oc2cc(O)cc(c2c(=O)c1O)O | 10.1021/ml2003058 | ||
| CHEMBL28626 | 2593 | None | 63 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -144 | 2 | Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assayAgonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay |
ChEMBL | 302 | 1 | 5 | 7 | 2.0 | Oc1ccc(c(c1)O)c1oc2cc(O)cc(c2c(=O)c1O)O | 10.1021/ml2003058 | ||
| 4488 | 205479 | None | 66 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assayAgonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay |
ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/ml2003058 | ||
| CHEMBL63323 | 205479 | None | 66 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assayAgonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay |
ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/ml2003058 | ||
| 70692387 | 75336 | None | 2 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | Agonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assayAgonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assay |
ChEMBL | 259 | 1 | 2 | 2 | 3.0 | Cc1c(C(=O)O)[nH]c2c(Br)csc12 | 10.1016/j.bmcl.2012.04.057 | ||
| CHEMBL2037465 | 75336 | None | 2 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | Agonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assayAgonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assay |
ChEMBL | 259 | 1 | 2 | 2 | 3.0 | Cc1c(C(=O)O)[nH]c2c(Br)csc12 | 10.1016/j.bmcl.2012.04.057 | ||
| 66561718 | 75333 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and Gal4-VP16 transcription factor assessed as beta arrestin translocation after 5 hrs by Tango assayAgonist activity at GPR35 in human U20S cells expressing beta-lactamase and Gal4-VP16 transcription factor assessed as beta arrestin translocation after 5 hrs by Tango assay |
ChEMBL | 275 | 2 | 1 | 4 | 4.0 | Cc1c(C(=O)O)sc2c(-c3cccnc3)csc12 | 10.1016/j.bmcl.2012.04.057 | ||
| CHEMBL2037462 | 75333 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and Gal4-VP16 transcription factor assessed as beta arrestin translocation after 5 hrs by Tango assayAgonist activity at GPR35 in human U20S cells expressing beta-lactamase and Gal4-VP16 transcription factor assessed as beta arrestin translocation after 5 hrs by Tango assay |
ChEMBL | 275 | 2 | 1 | 4 | 4.0 | Cc1c(C(=O)O)sc2c(-c3cccnc3)csc12 | 10.1016/j.bmcl.2012.04.057 | ||
| 172457931 | 196452 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 2 | Agonist activity at mouse GPR35 expressed in HEK293 cells co-expressing Galpha16 assessed as increase in calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at mouse GPR35 expressed in HEK293 cells co-expressing Galpha16 assessed as increase in calcium mobilization by Fluo-4 AM dye based fluorescence assay |
ChEMBL | 434 | 4 | 2 | 6 | 2.6 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CC2)c1Cl)C(=O)OC1CC1 | 10.1016/j.bmc.2023.117511 | ||
| CHEMBL5424229 | 196452 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 2 | Agonist activity at mouse GPR35 expressed in HEK293 cells co-expressing Galpha16 assessed as increase in calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at mouse GPR35 expressed in HEK293 cells co-expressing Galpha16 assessed as increase in calcium mobilization by Fluo-4 AM dye based fluorescence assay |
ChEMBL | 434 | 4 | 2 | 6 | 2.6 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CC2)c1Cl)C(=O)OC1CC1 | 10.1016/j.bmc.2023.117511 | ||
| 71733843 | 90890 | None | 7 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 87 | 3 | Agonist activity at human GPR35 by beta-arrestin recruitment assayAgonist activity at human GPR35 by beta-arrestin recruitment assay |
ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1016/j.bmc.2023.117511 | ||
| CHEMBL2392174 | 90890 | None | 7 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 87 | 3 | Agonist activity at human GPR35 by beta-arrestin recruitment assayAgonist activity at human GPR35 by beta-arrestin recruitment assay |
ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1016/j.bmc.2023.117511 | ||
| CHEMBL2425818 | 90890 | None | 7 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 87 | 3 | Agonist activity at human GPR35 by beta-arrestin recruitment assayAgonist activity at human GPR35 by beta-arrestin recruitment assay |
ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1016/j.bmc.2023.117511 | ||
| 172452315 | 196082 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | 11 | 2 | Agonist activity at mouse GPR35 expressed in HEK293 cells co-expressing Galpha16 assessed as increase in calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at mouse GPR35 expressed in HEK293 cells co-expressing Galpha16 assessed as increase in calcium mobilization by Fluo-4 AM dye based fluorescence assay |
ChEMBL | 320 | 2 | 4 | 4 | 0.8 | O=C(O)C(=O)Nc1cc(NC(=O)C(=O)O)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2023.117511 | ||
| CHEMBL5416593 | 196082 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | 11 | 2 | Agonist activity at mouse GPR35 expressed in HEK293 cells co-expressing Galpha16 assessed as increase in calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at mouse GPR35 expressed in HEK293 cells co-expressing Galpha16 assessed as increase in calcium mobilization by Fluo-4 AM dye based fluorescence assay |
ChEMBL | 320 | 2 | 4 | 4 | 0.8 | O=C(O)C(=O)Nc1cc(NC(=O)C(=O)O)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2023.117511 | ||
| 154634327 | 184845 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as dynamic mass redistribution response by DMR assayAgonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as dynamic mass redistribution response by DMR assay |
ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(Br)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | ||
| CHEMBL4850743 | 184845 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as dynamic mass redistribution response by DMR assayAgonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as dynamic mass redistribution response by DMR assay |
ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(Br)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | ||
Showing 1 to 50 of 1,377 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 135399235 | 4134 | None | 41 | Human | Binding | pEC50 | = | 9.2 | 9.2 | - | 1 | Agonist activity at GPR-35 in human HT-29 cells by DMR assayAgonist activity at GPR-35 in human HT-29 cells by DMR assay |
ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acsmedchemlett.2c00461 | ||
| 2919 | 4134 | None | 41 | Human | Binding | pEC50 | = | 9.2 | 9.2 | - | 1 | Agonist activity at GPR-35 in human HT-29 cells by DMR assayAgonist activity at GPR-35 in human HT-29 cells by DMR assay |
ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acsmedchemlett.2c00461 | ||
| 5722 | 4134 | None | 41 | Human | Binding | pEC50 | = | 9.2 | 9.2 | - | 1 | Agonist activity at GPR-35 in human HT-29 cells by DMR assayAgonist activity at GPR-35 in human HT-29 cells by DMR assay |
ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acsmedchemlett.2c00461 | ||
| CHEMBL28079 | 4134 | None | 41 | Human | Binding | pEC50 | = | 9.2 | 9.2 | - | 1 | Agonist activity at GPR-35 in human HT-29 cells by DMR assayAgonist activity at GPR-35 in human HT-29 cells by DMR assay |
ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acsmedchemlett.2c00461 | ||
| 12138435 | 68079 | None | 26 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assayAgonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay |
ChEMBL | 329 | 1 | 0 | 4 | 4.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1 | 10.1021/acs.jmedchem.6b01431 | ||
| CHEMBL1914576 | 68079 | None | 26 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assayAgonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay |
ChEMBL | 329 | 1 | 0 | 4 | 4.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1 | 10.1021/acs.jmedchem.6b01431 | ||
| 71733650 | 90877 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human GPR35b expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35b expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(F)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | ||
| CHEMBL2392161 | 90877 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human GPR35b expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35b expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(F)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | ||
| 694463 | 87514 | None | 63 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | Agonist activity at GPR35 in human HT-29 cells by DMR assayAgonist activity at GPR35 in human HT-29 cells by DMR assay |
ChEMBL | 268 | 1 | 1 | 3 | 2.3 | O=C(O)c1cc2cc(Br)ccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | ||
| CHEMBL2333943 | 87514 | None | 63 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | Agonist activity at GPR35 in human HT-29 cells by DMR assayAgonist activity at GPR35 in human HT-29 cells by DMR assay |
ChEMBL | 268 | 1 | 1 | 3 | 2.3 | O=C(O)c1cc2cc(Br)ccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | ||
| 71733848 | 90895 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assayAgonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay |
ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm4009373 | ||
| CHEMBL2392179 | 90895 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assayAgonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay |
ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm4009373 | ||
| 71733848 | 90895 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm400587g | ||
| CHEMBL2392179 | 90895 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm400587g | ||
| 71733848 | 90895 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm400587g | ||
| CHEMBL2392179 | 90895 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm400587g | ||
| 135399235 | 4134 | None | 41 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at GPR35 in human HT-29 cells assessed as induction of whole cell dynamic mass redistribution after 50 mins by resonant waveguide grating biosensor analysisAgonist activity at GPR35 in human HT-29 cells assessed as induction of whole cell dynamic mass redistribution after 50 mins by resonant waveguide grating biosensor analysis |
ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1039/C2MD20210G | ||
| 2919 | 4134 | None | 41 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at GPR35 in human HT-29 cells assessed as induction of whole cell dynamic mass redistribution after 50 mins by resonant waveguide grating biosensor analysisAgonist activity at GPR35 in human HT-29 cells assessed as induction of whole cell dynamic mass redistribution after 50 mins by resonant waveguide grating biosensor analysis |
ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1039/C2MD20210G | ||
| 5722 | 4134 | None | 41 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at GPR35 in human HT-29 cells assessed as induction of whole cell dynamic mass redistribution after 50 mins by resonant waveguide grating biosensor analysisAgonist activity at GPR35 in human HT-29 cells assessed as induction of whole cell dynamic mass redistribution after 50 mins by resonant waveguide grating biosensor analysis |
ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1039/C2MD20210G | ||
| CHEMBL28079 | 4134 | None | 41 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at GPR35 in human HT-29 cells assessed as induction of whole cell dynamic mass redistribution after 50 mins by resonant waveguide grating biosensor analysisAgonist activity at GPR35 in human HT-29 cells assessed as induction of whole cell dynamic mass redistribution after 50 mins by resonant waveguide grating biosensor analysis |
ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1039/C2MD20210G | ||
| 71733845 | 90892 | None | 0 | Rat | Binding | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at rat GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at rat GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccccc1C(=O)Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | ||
| CHEMBL2392176 | 90892 | None | 0 | Rat | Binding | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at rat GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at rat GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccccc1C(=O)Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | ||
| 4488 | 205479 | None | 66 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human GPR35 by DMR assayAgonist activity at human GPR35 by DMR assay |
ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/jm4009373 | ||
| CHEMBL63323 | 205479 | None | 66 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human GPR35 by DMR assayAgonist activity at human GPR35 by DMR assay |
ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/jm4009373 | ||
| 71733651 | 90878 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assayAgonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay |
ChEMBL | 357 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(F)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | ||
| CHEMBL2392162 | 90878 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assayAgonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay |
ChEMBL | 357 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(F)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | ||
| 71733651 | 90878 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 357 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(F)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | ||
| CHEMBL2392162 | 90878 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 357 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(F)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | ||
| 71734940 | 90879 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 385 | 5 | 1 | 6 | 3.4 | CCOC(=O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc(OC)cc3)c2o1 | 10.1021/jm400587g | ||
| CHEMBL2392163 | 90879 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 385 | 5 | 1 | 6 | 3.4 | CCOC(=O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc(OC)cc3)c2o1 | 10.1021/jm400587g | ||
| 118985385 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assayAgonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay |
ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | ||
| 1258 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assayAgonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay |
ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | ||
| 3440 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assayAgonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay |
ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | ||
| 4839 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assayAgonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay |
ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | ||
| CHEMBL35 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assayAgonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay |
ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | ||
| DB00695 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assayAgonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay |
ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | ||
| 71733650 | 90877 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(F)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | ||
| CHEMBL2392161 | 90877 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(F)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | ||
| 71733843 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | ||
| CHEMBL2392174 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | ||
| CHEMBL2425818 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | ||
| 71733843 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | ||
| CHEMBL2392174 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | ||
| CHEMBL2425818 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayAgonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay |
ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | ||
| 71733843 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assayAgonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay |
ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/acs.jmedchem.6b01431 | ||
| CHEMBL2392174 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assayAgonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay |
ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/acs.jmedchem.6b01431 | ||
| CHEMBL2425818 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assayAgonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay |
ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/acs.jmedchem.6b01431 | ||
| 2920 | 2997 | None | 64 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assayAgonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay |
ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm4009373 | ||
| 54742459 | 2997 | None | 64 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assayAgonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay |
ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm4009373 | ||
| 8546 | 2997 | None | 64 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assayAgonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay |
ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm4009373 | ||
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