GPCRdb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	122653602	191606	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	8	2	6	3.7	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)cc1F	nan
	CHEMBL4852000	191606	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	8	2	6	3.7	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)cc1F	nan
	122653721	191177	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	CHEMBL4845846	191177	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	122653713	191212	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4846330	191212	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1	nan
	122653650	191213	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1cc(Cl)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4846333	191213	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1cc(Cl)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653704	191217	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	409	6	2	4	3.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	CHEMBL4846416	191217	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	409	6	2	4	3.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	122653665	191231	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	510	7	2	5	4.0	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4846586	191231	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	510	7	2	5	4.0	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653719	191241	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccnc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4846775	191241	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccnc(C(F)(F)F)c2)ccn1	nan
	122653649	191247	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1	nan
	CHEMBL4846914	191247	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1	nan
	122653642	191255	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4846977	191255	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653806	191300	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	486	7	1	4	4.8	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4847685	191300	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	486	7	1	4	4.8	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653408	191302	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	475	7	3	5	3.0	O=C(NC[C@@H](O)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4847708	191302	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	475	7	3	5	3.0	O=C(NC[C@@H](O)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653470	191306	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NC[C@@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4847735	191306	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NC[C@@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653679	191339	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	5	2.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(Cl)nc2)ccn1	nan
	CHEMBL4848378	191339	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	5	2.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(Cl)nc2)ccn1	nan
	122653688	191340	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4848379	191340	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653654	191359	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	436	5	1	4	4.6	N#CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4848606	191359	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	436	5	1	4	4.6	N#CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653571	191368	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	CHEMBL4848812	191368	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	122653464	191391	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	2	4	4.2	O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4849056	191391	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	2	4	4.2	O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653683	191404	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	465	9	2	6	3.3	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(OC)c(F)c2)ccn1	nan
	CHEMBL4849398	191404	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	465	9	2	6	3.3	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(OC)c(F)c2)ccn1	nan
	122653417	191429	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4849645	191429	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653491	191434	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	368	4	2	3	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3[nH]ccc23)ccn1	nan
	CHEMBL4849698	191434	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	368	4	2	3	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3[nH]ccc23)ccn1	nan
	122653696	191453	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	5	1	4	4.5	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C(F)(F)F	nan
	CHEMBL4849904	191453	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	5	1	4	4.5	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C(F)(F)F	nan
	122653579	191458	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4849970	191458	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653601	191467	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1	nan
	CHEMBL4850054	191467	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1	nan
	122653613	191505	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	6	2	4	4.4	Cc1c(Cc2cccc(C(F)(F)F)c2)ccnc1N1CCc2c(C(=O)NCCO)cccc21	nan
	CHEMBL4850541	191505	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	6	2	4	4.4	Cc1c(Cc2cccc(C(F)(F)F)c2)ccnc1N1CCc2c(C(=O)NCCO)cccc21	nan
	122653676	191524	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4850812	191524	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1	nan
	122653686	191535	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	6	2	4	3.5	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4850965	191535	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	6	2	4	3.5	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653731	191542	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	460	6	2	5	3.1	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)N[C@H]5CCNC5=O)cccc43)c2)cc1F	nan
	CHEMBL4851069	191542	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	460	6	2	5	3.1	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)N[C@H]5CCNC5=O)cccc43)c2)cc1F	nan
	122653592	191561	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	379	4	1	3	4.0	CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	CHEMBL4851368	191561	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	379	4	1	3	4.0	CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	122653436	191562	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	9	2	5	3.5	O=C(NCCOCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4851394	191562	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	9	2	5	3.5	O=C(NCCOCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653690	191568	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	369	4	1	4	4.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4851533	191568	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	369	4	1	4	4.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653558	191569	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4851577	191569	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653573	191588	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	394	5	1	5	3.5	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1Cl	nan
	CHEMBL4851800	191588	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	394	5	1	5	3.5	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1Cl	nan
	122653608	191598	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	7	2	5	3.3	CC(=O)c1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ccn2)c1	nan
	CHEMBL4851936	191598	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	7	2	5	3.3	CC(=O)c1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ccn2)c1	nan
	122653448	191620	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(Cl)c2)ccn1	nan
	CHEMBL4852273	191620	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(Cl)c2)ccn1	nan
	122653452	191626	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	4	1	4	3.4	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	CHEMBL4852339	191626	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	4	1	4	3.4	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	122653453	191633	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@H](O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4852404	191633	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@H](O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653427	191659	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	373	4	1	5	3.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)OCO3)ccn1	nan
	CHEMBL4852734	191659	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	373	4	1	5	3.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)OCO3)ccn1	nan
	122653420	191684	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	5	3.8	O=C(N[C@H]1CCOC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4853193	191684	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	5	3.8	O=C(N[C@H]1CCOC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122654155	191702	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	429	6	1	3	4.5	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4853351	191702	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	429	6	1	3	4.5	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653581	191715	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4853555	191715	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653658	191716	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	483	7	2	5	3.5	O=C(NCC1(CO)COC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4853557	191716	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	483	7	2	5	3.5	O=C(NCC1(CO)COC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653641	191724	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	348	4	1	5	3.1	Cc1noc(C)c1Cc1ccnc(N2CCc3c(C(N)=O)cccc32)c1	nan
	CHEMBL4853689	191724	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	348	4	1	5	3.1	Cc1noc(C)c1Cc1ccnc(N2CCc3c(C(N)=O)cccc32)c1	nan
	122653547	191734	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	391	6	1	4	4.0	CCOc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4853824	191734	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	391	6	1	4	4.0	CCOc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653619	191741	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	429	6	1	3	4.5	O=C(NCCF)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4853939	191741	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	429	6	1	3	4.5	O=C(NCCF)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653645	191753	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4854092	191753	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653725	191755	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4854146	191755	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653537	191758	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	494	5	1	4	5.2	CN1CCC(NC(=O)c2cccc3c2CCN3c2cc(Cc3cccc(C(F)(F)F)c3)ccn2)CC1	nan
	CHEMBL4854218	191758	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	494	5	1	4	5.2	CN1CCC(NC(=O)c2cccc3c2CCN3c2cc(Cc3cccc(C(F)(F)F)c3)ccn2)CC1	nan
	122653488	191785	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@H](O)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4854701	191785	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@H](O)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653599	191791	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	319	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccoc2)ccn1	nan
	CHEMBL4854849	191791	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	319	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccoc2)ccn1	nan
	122653722	191807	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4855055	191807	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653455	191811	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4855110	191811	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653627	191821	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	452	7	1	4	4.5	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4855290	191821	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	452	7	1	4	4.5	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653632	191837	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	494	7	1	4	4.1	O=C(NCCN1CCCC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4855414	191837	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	494	7	1	4	4.1	O=C(NCCN1CCCC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653486	191848	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4855646	191848	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653810	191858	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	4	1	3	5.1	CNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)cc(C)n1	nan
	CHEMBL4855829	191858	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	4	1	3	5.1	CNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)cc(C)n1	nan
	122653618	191868	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	6	1	4	4.8	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4856011	191868	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	6	1	4	4.8	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	164609725	191876	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	447	7	1	4	5.2	O=C(NCC(F)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4856051	191876	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	447	7	1	4	5.2	O=C(NCC(F)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	164609750	191902	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	536	8	2	5	4.7	O=C(NCC(O)Cc1cccnc1)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4856315	191902	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	536	8	2	5	4.7	O=C(NCC(O)Cc1cccnc1)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	164614108	191910	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	8	1	5	4.8	COC[C@@H](F)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4856557	191910	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	8	1	5	4.8	COC[C@@H](F)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	164614116	191915	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	524	8	1	5	4.8	O=C(NCCCN1CCOCC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4856676	191915	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	524	8	1	5	4.8	O=C(NCCCN1CCOCC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653723	191922	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	359	5	1	4	3.5	COc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4856786	191922	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	359	5	1	4	3.5	COc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653607	191927	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4856937	191927	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653609	192010	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4858042	192010	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653629	192011	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	361	5	1	6	2.3	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	CHEMBL4858047	192011	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	361	5	1	6	2.3	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	122653504	192017	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	483	5	1	4	4.1	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)c[n+]([O-])c1	nan
	CHEMBL4858187	192017	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	483	5	1	4	4.1	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)c[n+]([O-])c1	nan
	122653540	192024	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4858311	192024	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653412	192033	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	7	2	4	4.5	O=C(NCCc1cnc[nH]1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4858448	192033	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	7	2	4	4.5	O=C(NCCc1cnc[nH]1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653473	192041	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	486	7	2	4	3.8	CC(=O)NCCNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4858574	192041	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	486	7	2	4	3.8	CC(=O)NCCNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653489	192105	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	378	5	1	5	3.0	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4859593	192105	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	378	5	1	5	3.0	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653708	192125	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	383	4	1	3	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4860064	192125	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	383	4	1	3	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653667	192138	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	6	2	5	3.8	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4860274	192138	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	6	2	5	3.8	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653407	192141	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4860294	192141	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653481	192194	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	516	8	2	6	3.9	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)ccc1F	nan
	CHEMBL4861199	192194	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	516	8	2	6	3.9	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)ccc1F	nan
	122653808	192213	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	498	7	2	6	3.5	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	CHEMBL4861454	192213	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	498	7	2	6	3.5	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	122653426	192242	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	480	5	2	4	3.8	O=C1CCC(NC(=O)c2cccc3c2CCN3c2cc(Cc3cc(F)c(F)c(F)c3)ccn2)CN1	nan
	CHEMBL4861879	192242	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	480	5	2	4	3.8	O=C1CCC(NC(=O)c2cccc3c2CCN3c2cc(Cc3cc(F)c(F)c(F)c3)ccn2)CN1	nan
	122653405	192248	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4861950	192248	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653749	192285	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	475	7	3	5	3.0	O=C(NC(CO)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4862500	192285	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	475	7	3	5	3.0	O=C(NC(CO)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653745	192290	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	8	2	6	3.3	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCC5(CO)COC5)cccc43)c2)cc1F	nan
	CHEMBL4862529	192290	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	8	2	6	3.3	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCC5(CO)COC5)cccc43)c2)cc1F	nan
	122653500	192327	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	8	2	5	3.7	COC[C@@H](O)CNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4863091	192327	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	8	2	5	3.7	COC[C@@H](O)CNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653416	192332	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	7	2	4	4.5	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4863198	192332	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	7	2	4	4.5	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653669	192352	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	417	4	1	4	4.8	NC(=O)c1cccc2c1CCN2c1cc(Oc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4863386	192352	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	417	4	1	4	4.8	NC(=O)c1cccc2c1CCN2c1cc(Oc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653624	192357	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	364	4	1	4	3.5	NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(Cl)c2)ccn1	nan
	CHEMBL4863447	192357	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	364	4	1	4	3.5	NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(Cl)c2)ccn1	nan
	122653435	192363	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	439	7	2	5	3.4	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCO)c2)cc1F	nan
	CHEMBL4863562	192363	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	439	7	2	5	3.4	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCO)c2)cc1F	nan
	122653567	192364	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4863576	192364	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653804	192366	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	464	5	2	4	3.8	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4863613	192366	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	464	5	2	4	3.8	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653543	192371	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	452	5	2	5	3.7	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4863658	192371	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	452	5	2	5	3.7	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653554	192384	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	9	2	6	3.9	O=C(NCCOCCO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4863892	192384	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	9	2	6	3.9	O=C(NCCOCCO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653694	192394	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4864049	192394	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653480	192416	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4864397	192416	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653747	192422	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)n2)ccn1	nan
	CHEMBL4864476	192422	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)n2)ccn1	nan
	122653506	192449	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4864933	192449	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653610	192456	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4865057	192456	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653750	192461	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1Cl	nan
	CHEMBL4865124	192461	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1Cl	nan
	122653520	192462	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	508	7	2	5	4.3	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4865128	192462	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	508	7	2	5	4.3	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653728	192491	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4865653	192491	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653434	192502	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4865786	192502	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653569	192507	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2ccc(F)c(C(F)(F)F)c2)c1	nan
	CHEMBL4865910	192507	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2ccc(F)c(C(F)(F)F)c2)c1	nan
	122653712	192512	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(Cl)c(F)c2)ccn1	nan
	CHEMBL4865996	192512	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(Cl)c(F)c2)ccn1	nan
	122653803	192522	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4866193	192522	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653465	192544	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	319	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccco2)ccn1	nan
	CHEMBL4866434	192544	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	319	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccco2)ccn1	nan
	122653620	192547	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	6	2	4	4.5	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4866463	192547	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	6	2	4	4.5	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653724	192554	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@@H](O)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4866543	192554	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@@H](O)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653706	192561	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	2	4	4.2	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4866626	192561	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	2	4	4.2	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122660774	192568	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2cc(N3CCc4c(C(=O)NC[C@@H](O)CF)cccc43)ccn2)cc1F	nan
	CHEMBL4866746	192568	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2cc(N3CCc4c(C(=O)NC[C@@H](O)CF)cccc43)ccn2)cc1F	nan
	122653748	192575	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.3	C[C@H](O)[C@@H](CO)NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4866874	192575	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.3	C[C@H](O)[C@@H](CO)NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653717	192589	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)n2)ccn1	nan
	CHEMBL4867044	192589	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)n2)ccn1	nan
	122653680	192628	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	524	7	2	5	4.6	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4867659	192628	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	524	7	2	5	4.6	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653626	192629	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COCC(O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4867681	192629	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COCC(O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653477	192657	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1cc(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4868214	192657	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1cc(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653697	192675	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	373	5	1	4	3.8	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C	nan
	CHEMBL4868562	192675	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	373	5	1	4	3.8	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C	nan
	122653462	192680	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4868643	192680	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653545	192688	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	380	4	1	4	4.0	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3ncccc23)ccn1	nan
	CHEMBL4868799	192688	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	380	4	1	4	4.0	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3ncccc23)ccn1	nan
	122653419	192696	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	7	1	4	4.4	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCF)c2)cc1F	nan
	CHEMBL4868949	192696	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	7	1	4	4.4	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCF)c2)cc1F	nan
	122653460	192697	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	6	2	5	3.0	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	CHEMBL4869015	192697	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	6	2	5	3.0	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	122653519	192700	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4869072	192700	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653693	192705	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	7	2	4	3.9	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4869130	192705	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	7	2	4	3.9	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653518	192706	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4869139	192706	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653692	192715	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	389	5	1	4	3.8	CC(=O)c1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4869262	192715	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	389	5	1	4	3.8	CC(=O)c1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653691	192717	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	5	2	4	3.5	O=C(N[C@@H]1CCNC1=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4869305	192717	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	5	2	4	3.5	O=C(N[C@@H]1CCNC1=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653630	192728	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	8	2	5	3.7	COC[C@H](O)CNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4869524	192728	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	8	2	5	3.7	COC[C@H](O)CNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653483	192761	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4869851	192761	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653648	192765	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	395	5	1	4	3.8	COc1c(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4870024	192765	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	395	5	1	4	3.8	COc1c(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653406	192766	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	2	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(CO)c(F)c2)ccn1	nan
	CHEMBL4870029	192766	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	2	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(CO)c(F)c2)ccn1	nan
	122653709	192819	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	355	4	1	5	2.7	N#Cc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	CHEMBL4870751	192819	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	355	4	1	5	2.7	N#Cc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	122653458	192826	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4870894	192826	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653638	192828	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	2	4	3.7	CC(=O)NCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4870900	192828	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	2	4	3.7	CC(=O)NCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653428	192839	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	5	4.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4871052	192839	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	5	4.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ccn1	nan
	122653751	192853	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(F)c2)ccn1	nan
	CHEMBL4871344	192853	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(F)c2)ccn1	nan
	122653586	192911	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	7	1	5	4.4	O=C(NCCn1ccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4871971	192911	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	7	1	5	4.4	O=C(NCCn1ccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653589	192917	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(Cl)c2)ccn1	nan
	CHEMBL4872112	192917	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(Cl)c2)ccn1	nan
	122653461	192923	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4872227	192923	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653597	192933	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	542	7	2	5	4.7	O=C(NC1CCN(CCO)CC1)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4872358	192933	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	542	7	2	5	4.7	O=C(NC1CCN(CCO)CC1)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122660773	193037	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2cc(N3CCc4c(C(=O)NC[C@H](O)CF)cccc43)ccn2)cc1F	nan
	CHEMBL4873801	193037	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2cc(N3CCc4c(C(=O)NC[C@H](O)CF)cccc43)ccn2)cc1F	nan
	122653482	193038	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4873808	193038	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653628	193053	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4874029	193053	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653590	193092	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4874627	193092	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653603	193128	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	458	5	1	4	5.8	O=C(Nc1ccncc1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4875102	193128	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	458	5	1	4	5.8	O=C(Nc1ccncc1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653521	193131	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1ccccn1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4875163	193131	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1ccccn1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	164629075	193139	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	508	8	1	4	5.6	O=C(NCCCN1CCCC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4875342	193139	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	508	8	1	4	5.6	O=C(NCCCN1CCCC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653698	193145	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	435	5	1	4	4.2	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	CHEMBL4875443	193145	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	435	5	1	4	4.2	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	122653514	193158	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	5	2	4	3.5	O=C(N[C@H]1CCNC1=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4875637	193158	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	5	2	4	3.5	O=C(N[C@H]1CCNC1=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122654150	193193	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	363	4	2	4	3.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(O)c2)ccn1	nan
	CHEMBL4876057	193193	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	363	4	2	4	3.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(O)c2)ccn1	nan
	122653705	193196	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	360	5	1	5	2.9	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	CHEMBL4876095	193196	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	360	5	1	5	2.9	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	122653595	193210	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	382	4	1	4	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(F)c(Cl)c2)ccn1	nan
	CHEMBL4876282	193210	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	382	4	1	4	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(F)c(Cl)c2)ccn1	nan
	122653585	193227	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	1	4	4.7	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4876504	193227	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	1	4	4.7	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653634	193255	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@H](F)CO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4876839	193255	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@H](F)CO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653720	193277	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	421	7	2	5	3.2	COc1cc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)ccc1F	nan
	CHEMBL4877278	193277	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	421	7	2	5	3.2	COc1cc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)ccc1F	nan
	122653695	193278	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1ccncc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4877331	193278	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1ccncc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653677	193288	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1	nan
	CHEMBL4877494	193288	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1	nan
	122653672	193291	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1Cl	nan
	CHEMBL4877524	193291	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1Cl	nan
	122653640	193308	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1cc(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4877713	193308	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1cc(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653538	193320	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)n1	nan
	CHEMBL4877909	193320	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)n1	nan
	122653534	193336	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)c[n+]([O-])c1	nan
	CHEMBL4878069	193336	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)c[n+]([O-])c1	nan
	122653451	193339	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4878142	193339	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653510	193345	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	389	5	1	4	3.8	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	CHEMBL4878221	193345	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	389	5	1	4	3.8	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	122653549	193365	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC[C@@H](F)CO)cccc43)c2)cc1F	nan
	CHEMBL4878529	193365	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC[C@@H](F)CO)cccc43)c2)cc1F	nan
	122653729	193374	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4878629	193374	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653583	193401	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NCC(O)CF)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4879330	193401	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NCC(O)CF)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653714	192681	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4868685	192681	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653423	192319	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	433	7	2	5	3.4	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)ccc1F	nan
	CHEMBL4862971	192319	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	433	7	2	5	3.4	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)ccc1F	nan
	122653512	192930	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	480	8	2	5	3.5	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCNC(C)=O)c2)cc1F	nan
	CHEMBL4872333	192930	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	480	8	2	5	3.5	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCNC(C)=O)c2)cc1F	nan
	162676039	190242	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	456	6	2	6	3.1	O=C(c1cccc(C(F)(F)F)c1)c1cc(N2CCc3c(C(=O)NCCO)cccc32)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4799062	190242	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	456	6	2	6	3.1	O=C(c1cccc(C(F)(F)F)c1)c1cc(N2CCc3c(C(=O)NCCO)cccc32)ncn1	10.1021/acs.jmedchem.0c01498
	162662654	188672	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4779158	188672	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	122653659	191325	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1	nan
	CHEMBL4848041	191325	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1	nan
	162659079	188062	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	392	6	2	5	2.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4762205	188062	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	392	6	2	5	2.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162663893	188785	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(C(F)(F)F)cc2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4780640	188785	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(C(F)(F)F)cc2)ncn1	10.1021/acs.jmedchem.0c01498
	54670455	162578	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	408	4	1	3	5.3	Cc1cc(-c2sc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4059658	162578	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	408	4	1	3	5.3	Cc1cc(-c2sc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653588	191964	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	5	1	4	3.7	CC(=O)c1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4857429	191964	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	5	1	4	3.7	CC(=O)c1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653600	192466	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	CHEMBL4865212	192466	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	137640725	163810	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	444	4	1	3	5.8	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(C(F)(F)F)c1	10.1016/j.bmc.2017.03.064
	CHEMBL4073584	163810	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	444	4	1	3	5.8	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(C(F)(F)F)c1	10.1016/j.bmc.2017.03.064
	162644528	186169	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	443	6	3	6	3.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Nc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4739868	186169	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	443	6	3	6	3.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Nc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162655320	187493	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	410	6	2	5	2.8	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4755625	187493	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	410	6	2	5	2.8	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	122653730	186960	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4749272	186960	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	10.1021/acs.jmedchem.0c01498
	122653687	192314	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4862838	192314	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653670	192294	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4862614	192294	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653730	186960	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4749272	186960	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653499	192845	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)cc(Cl)c2)c1	nan
	CHEMBL4871179	192845	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)cc(Cl)c2)c1	nan
	137654783	165657	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3cccc(Cl)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4095110	165657	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3cccc(Cl)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	162655975	187564	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	458	7	2	6	3.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(OC(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4756386	187564	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	458	7	2	6	3.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(OC(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	155977949	188788	17	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4780654	188788	17	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	137659986	165994	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	390	4	1	3	5.1	Cc1cc(C(N)=O)ccc1-c1sc(Cc2cccc(C(F)(F)F)c2)nc1C	10.1016/j.bmc.2017.03.064
	CHEMBL4098770	165994	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	390	4	1	3	5.1	Cc1cc(C(N)=O)ccc1-c1sc(Cc2cccc(C(F)(F)F)c2)nc1C	10.1016/j.bmc.2017.03.064
	122653605	193290	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	5	3.8	O=C(N[C@@H]1CCOC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4877497	193290	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	5	3.8	O=C(N[C@@H]1CCOC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	69921128	171849	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	Cc1c(C(=O)NCCO)c(CO)nn1-c1cccc2cc(Cc3cccc(C(F)(F)F)c3)sc12	10.1016/j.bmc.2018.02.005
	CHEMBL4226751	171849	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	Cc1c(C(=O)NCCO)c(CO)nn1-c1cccc2cc(Cc3cccc(C(F)(F)F)c3)sc12	10.1016/j.bmc.2018.02.005
	69921041	171998	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	6	2	5	5.0	Cc1nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c(C)c1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	CHEMBL4229063	171998	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	6	2	5	5.0	Cc1nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c(C)c1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	162660100	188007	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)cnn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4761453	188007	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)cnn1	10.1021/acs.jmedchem.0c01498
	162660762	188036	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	6	3.3	O=C(c1cc(F)cc(C(F)(F)F)c1)c1ccnc(N2CCc3c(C(=O)NCCO)cccc32)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4761816	188036	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	6	3.3	O=C(c1cc(F)cc(C(F)(F)F)c1)c1ccnc(N2CCc3c(C(=O)NCCO)cccc32)n1	10.1021/acs.jmedchem.0c01498
	122653655	193155	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	5	1	4	3.7	CC(=O)c1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1	nan
	CHEMBL4875581	193155	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	5	1	4	3.7	CC(=O)c1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1	nan
	137647647	164431	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	352	5	1	4	4.1	COc1cccc(Cc2nc(C)c(-c3ccc(C(N)=O)c(C)c3)s2)c1	10.1016/j.bmc.2017.03.064
	CHEMBL4081439	164431	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	352	5	1	4	4.1	COc1cccc(Cc2nc(C)c(-c3ccc(C(N)=O)c(C)c3)s2)c1	10.1016/j.bmc.2017.03.064
	162652816	187156	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	6	3.3	O=C(c1cc(F)cc(C(F)(F)F)c1)c1cc(N2CCc3c(C(=O)NCCO)cccc32)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4751676	187156	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	6	3.3	O=C(c1cc(F)cc(C(F)(F)F)c1)c1cc(N2CCc3c(C(=O)NCCO)cccc32)ncn1	10.1021/acs.jmedchem.0c01498
	70922254	171844	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	487	7	1	5	5.7	COCCNC(=O)c1c(C)nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1C	10.1016/j.bmc.2018.02.005
	CHEMBL4226695	171844	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	487	7	1	5	5.7	COCCNC(=O)c1c(C)nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1C	10.1016/j.bmc.2018.02.005
	122653422	192734	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	362	4	1	4	3.3	Cc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cnc1F	nan
	CHEMBL4869553	192734	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	362	4	1	4	3.3	Cc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cnc1F	nan
	137635271	162803	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	406	5	1	4	4.8	COc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4062229	162803	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	406	5	1	4	4.8	COc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653459	191189	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	2	4	3.7	CNC(=O)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4846042	191189	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	2	4	3.7	CNC(=O)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653726	192393	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.7	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NC[C@@H](F)CO)c2)cc1F	nan
	CHEMBL4864048	192393	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.7	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NC[C@@H](F)CO)c2)cc1F	nan
	122653449	191328	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	495	7	2	4	3.5	O=C(NCCN1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4848165	191328	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	495	7	2	4	3.5	O=C(NCCN1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	162656501	187674	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1nccc(Cc2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4757616	187674	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1nccc(Cc2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	59193825	119193	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	441	6	2	3	4.6	O=C(NCCO)c1cccc(-c2cccc3c2OC(Cc2cccc(C(F)(F)F)c2)C3)c1	10.1021/jm5002919
	CHEMBL3297807	119193	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	441	6	2	3	4.6	O=C(NCCO)c1cccc(-c2cccc3c2OC(Cc2cccc(C(F)(F)F)c2)C3)c1	10.1021/jm5002919
	69921479	8153	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	10.1016/j.bmc.2018.02.005
	9804	8153	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	10.1016/j.bmc.2018.02.005
	CHEMBL4228912	8153	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	10.1016/j.bmc.2018.02.005
	122653611	191952	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	387	5	1	5	3.4	CC(=O)Oc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4857269	191952	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	387	5	1	5	3.4	CC(=O)Oc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122654148	191872	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4856037	191872	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	137637645	163001	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3ccc(Cl)cc3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4064577	163001	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3ccc(Cl)cc3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653689	192296	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	401	4	1	5	3.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)OCCCO3)ccn1	nan
	CHEMBL4862638	192296	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	401	4	1	5	3.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)OCCCO3)ccn1	nan
	137644761	165270	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	376	4	1	3	4.8	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)cc1	10.1016/j.bmc.2017.03.064
	CHEMBL4091030	165270	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	376	4	1	3	4.8	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)cc1	10.1016/j.bmc.2017.03.064
	122653437	191459	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	404	5	2	4	3.0	CNC(=O)c1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	CHEMBL4849975	191459	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	404	5	2	4	3.0	CNC(=O)c1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	56651044	164925	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	391	4	1	3	4.2	Cc1cc(-c2cc(Cc3cc(F)cc(C(F)(F)F)c3)nn2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4087237	164925	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	391	4	1	3	4.2	Cc1cc(-c2cc(Cc3cc(F)cc(C(F)(F)F)c3)nn2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653604	192860	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	5	1	4	4.4	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(OC(F)(F)F)c2)ccn1	nan
	CHEMBL4871459	192860	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	5	1	4	4.4	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(OC(F)(F)F)c2)ccn1	nan
	122653668	192158	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	463	5	1	5	4.8	Cn1cc(NC(=O)c2cccc3c2CCN3c2cc(Cc3cc(F)c(F)c(F)c3)ccn2)cn1	nan
	CHEMBL4860543	192158	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	463	5	1	5	4.8	Cn1cc(NC(=O)c2cccc3c2CCN3c2cc(Cc3cc(F)c(F)c(F)c3)ccn2)cn1	nan
	162662725	188673	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	444	6	2	6	3.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Oc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4779168	188673	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	444	6	2	6	3.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Oc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	137649487	163980	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	374	4	1	3	4.9	Cc1cc(-c2sc(Cc3cc(F)cc(Cl)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4075971	163980	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	374	4	1	3	4.9	Cc1cc(-c2sc(Cc3cc(F)cc(Cl)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	137639427	163561	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	340	4	1	3	4.3	Cc1cc(-c2sc(Cc3cccc(F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4070849	163561	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	340	4	1	3	4.3	Cc1cc(-c2sc(Cc3cccc(F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	162644756	186221	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	7	2	5	4.0	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4740473	186221	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	7	2	5	4.0	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	44623954	7919	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	10.1021/jm5002919
	8840	7919	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	10.1021/jm5002919
	CHEMBL3299119	7919	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	10.1021/jm5002919
	59193920	119222	5	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	453	7	1	3	6.3	COCCNC(=O)c1cccc(-c2cccc3cc(Cc4cc(F)cc(Cl)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3298233	119222	5	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	453	7	1	3	6.3	COCCNC(=O)c1cccc(-c2cccc3cc(Cc4cc(F)cc(Cl)c4)sc23)c1	10.1021/jm5002919
	122653478	191288	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	495	6	2	4	4.4	O=C(NC[C@H](O)C(F)(F)F)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4847442	191288	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	495	6	2	4	4.4	O=C(NC[C@H](O)C(F)(F)F)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	162665315	189026	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	374	6	2	5	2.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccccc2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4783576	189026	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	374	6	2	5	2.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccccc2)ncn1	10.1021/acs.jmedchem.0c01498
	122653639	191406	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	421	7	2	5	3.2	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)cc1F	nan
	CHEMBL4849417	191406	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	421	7	2	5	3.2	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)cc1F	nan
	122653746	193270	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	6	2	4	3.6	O=C(NCCO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4877187	193270	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	6	2	4	3.6	O=C(NCCO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653653	191512	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	485	9	1	5	4.2	COCC(COC)NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4850677	191512	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	485	9	1	5	4.2	COCC(COC)NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653556	192983	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	469	8	2	5	3.9	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4873066	192983	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	469	8	2	5	3.9	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	162654687	187379	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	478	6	2	5	4.1	O=C(NCCO)c1cccc2c1CCN2c1nccc(C(F)c2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4754435	187379	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	478	6	2	5	4.1	O=C(NCCO)c1cccc2c1CCN2c1nccc(C(F)c2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	162675088	190096	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	478	6	2	5	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(C(F)c2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4797286	190096	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	478	6	2	5	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(C(F)c2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162674993	190150	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	476	6	3	6	3.1	O=C(NCCO)c1cccc2c1CCN2c1cc(C(O)c2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4797830	190150	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	476	6	3	6	3.1	O=C(NCCO)c1cccc2c1CCN2c1cc(C(O)c2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	59193747	119315	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	O=C(NCCO)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)oc23)c1	10.1021/jm5002919
	CHEMBL3299120	119315	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	O=C(NCCO)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)oc23)c1	10.1021/jm5002919
	162655237	187488	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	490	7	3	6	3.0	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4755614	187488	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	490	7	3	6	3.0	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	122653637	192840	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	363	4	2	4	3.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(O)c(F)c2)ccn1	nan
	CHEMBL4871096	192840	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	363	4	2	4	3.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(O)c(F)c2)ccn1	nan
	162672139	189694	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	404	7	2	6	2.5	COc1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	CHEMBL4792434	189694	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	404	7	2	6	2.5	COc1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	122653507	192997	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	450	6	1	4	5.0	N#CCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4873264	192997	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	450	6	1	4	5.0	N#CCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653498	192608	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	2	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(CO)c2)ccn1	nan
	CHEMBL4867455	192608	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	2	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(CO)c2)ccn1	nan
	122653457	191849	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NC[C@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4855685	191849	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NC[C@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	59194084	119317	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	455	6	2	3	5.9	O=C(NCCO)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3299122	119317	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	455	6	2	3	5.9	O=C(NCCO)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	137639301	163734	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	418	5	1	3	6.0	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(C(C)C)c1	10.1016/j.bmc.2017.03.064
	CHEMBL4072782	163734	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	418	5	1	3	6.0	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(C(C)C)c1	10.1016/j.bmc.2017.03.064
	162652119	187122	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	6	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4751311	187122	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	6	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162677433	190290	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4799772	190290	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	122653552	192647	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	386	6	1	4	3.5	CN(C)Cc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4868031	192647	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	386	6	1	4	3.5	CN(C)Cc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	59193882	119316	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	455	6	2	3	5.9	O=C(NCCO)c1cccc(-c2cccc3sc(Cc4cccc(C(F)(F)F)c4)cc23)c1	10.1021/jm5002919
	CHEMBL3299121	119316	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	455	6	2	3	5.9	O=C(NCCO)c1cccc(-c2cccc3sc(Cc4cccc(C(F)(F)F)c4)cc23)c1	10.1021/jm5002919
	122653447	193232	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	369	4	1	4	4.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc3ccccc3o2)ccn1	nan
	CHEMBL4876570	193232	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	369	4	1	4	4.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc3ccccc3o2)ccn1	nan
	59193828	119318	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	4	4.5	O=C(NCCO)c1cccc(-c2cccc3nn(Cc4cccc(C(F)(F)F)c4)cc23)c1	10.1021/jm5002919
	CHEMBL3299123	119318	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	4	4.5	O=C(NCCO)c1cccc(-c2cccc3nn(Cc4cccc(C(F)(F)F)c4)cc23)c1	10.1021/jm5002919
	137648436	164657	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	394	4	1	3	5.0	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(F)c1	10.1016/j.bmc.2017.03.064
	CHEMBL4083957	164657	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	394	4	1	3	5.0	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(F)c1	10.1016/j.bmc.2017.03.064
	137648989	163888	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3ccccc3Cl)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4074656	163888	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3ccccc3Cl)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	162654874	187367	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	488	8	2	5	4.4	O=C(NCCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4754346	187367	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	488	8	2	5	4.4	O=C(NCCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162655610	187516	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	476	6	3	6	3.1	O=C(NCCO)c1cccc2c1CCN2c1nccc(C(O)c2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4755935	187516	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	476	6	3	6	3.1	O=C(NCCO)c1cccc2c1CCN2c1nccc(C(O)c2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	137659770	166062	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	377	4	1	4	4.2	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)cn1	10.1016/j.bmc.2017.03.064
	CHEMBL4099457	166062	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	377	4	1	4	4.2	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)cn1	10.1016/j.bmc.2017.03.064
	67185105	119196	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	469	7	1	3	6.6	COCCNC(=O)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3297811	119196	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	469	7	1	3	6.6	COCCNC(=O)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	122653539	191933	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	4	5.0	NC(=O)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4857044	191933	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	4	5.0	NC(=O)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ccn1	nan
	162647123	186306	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	462	6	1	4	4.6	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4741318	186306	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	462	6	1	4	4.6	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	69921111	171973	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	6	2	5	4.6	Cn1nc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)cc1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	CHEMBL4228734	171973	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	6	2	5	4.6	Cn1nc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)cc1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	162649639	186860	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	7	1	5	4.3	COCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4748048	186860	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	7	1	5	4.3	COCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	69921074	171821	1	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	6	2	5	4.7	Cc1nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)cc1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	CHEMBL4226295	171821	1	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	6	2	5	4.7	Cc1nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)cc1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	122653454	191322	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4847995	191322	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653710	192234	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	423	7	1	4	4.2	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCF)cccc43)c2)cc1F	nan
	CHEMBL4861734	192234	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	423	7	1	4	4.2	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCF)cccc43)c2)cc1F	nan
	122653718	192256	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4862064	192256	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	59193981	119195	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	468	6	2	3	5.4	NC(=O)CNC(=O)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3297810	119195	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	468	6	2	3	5.4	NC(=O)CNC(=O)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	122653716	192907	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	501	7	2	5	3.7	O=C(NCC1(CO)COC1)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4871931	192907	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	501	7	2	5	3.7	O=C(NCC1(CO)COC1)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	162668388	189533	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	4.0	O=C(NCCO)c1cccc2c1CCN2c1cc(C(F)c2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4790115	189533	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	4.0	O=C(NCCO)c1cccc2c1CCN2c1cc(C(F)c2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162665062	188857	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	458	6	3	6	3.0	O=C(NCCO)c1cccc2c1CCN2c1cc(C(O)c2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4781520	188857	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	458	6	3	6	3.0	O=C(NCCO)c1cccc2c1CCN2c1cc(C(O)c2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162656735	187629	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	494	6	2	5	4.3	O=C(NCCO)c1cccc2c1CCN2c1nncc(Cc2cc(F)cc(C(F)(F)F)c2)c1Cl	10.1021/acs.jmedchem.0c01498
	CHEMBL4757171	187629	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	494	6	2	5	4.3	O=C(NCCO)c1cccc2c1CCN2c1nncc(Cc2cc(F)cc(C(F)(F)F)c2)c1Cl	10.1021/acs.jmedchem.0c01498
	137661708	166248	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	391	4	1	3	4.3	Cc1cc(-n2cc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4101517	166248	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	391	4	1	3	4.3	Cc1cc(-n2cc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653471	192412	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	8	2	5	3.4	CN(C)CC(O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4864354	192412	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	8	2	5	3.4	CN(C)CC(O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653560	192593	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)n1	nan
	CHEMBL4867123	192593	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)n1	nan
	122653474	193188	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	380	4	1	4	4.0	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc3ccccc3c2)ccn1	nan
	CHEMBL4876029	193188	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	380	4	1	4	4.0	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc3ccccc3c2)ccn1	nan
	122653651	191879	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	366	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(F)c(F)c2)ccn1	nan
	CHEMBL4856067	191879	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	366	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(F)c(F)c2)ccn1	nan
	70922218	171818	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	7	1	5	5.1	COCCNC(=O)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1016/j.bmc.2018.02.005
	CHEMBL4226253	171818	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	7	1	5	5.1	COCCNC(=O)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1016/j.bmc.2018.02.005
	69921013	171848	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	7	1	5	5.4	COCCNC(=O)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1C	10.1016/j.bmc.2018.02.005
	CHEMBL4226750	171848	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	7	1	5	5.4	COCCNC(=O)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1C	10.1016/j.bmc.2018.02.005
	59193856	119319	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	4	4.5	O=C(NCCO)c1cccc(-c2cccc3cn(Cc4cccc(C(F)(F)F)c4)nc23)c1	10.1021/jm5002919
	CHEMBL3299124	119319	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	4	4.5	O=C(NCCO)c1cccc(-c2cccc3cn(Cc4cccc(C(F)(F)F)c4)nc23)c1	10.1021/jm5002919
	59193730	119320	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	441	6	2	3	4.6	O=C(NCCO)c1cccc(-c2cccc3c2CC(Cc2cccc(C(F)(F)F)c2)O3)c1	10.1021/jm5002919
	CHEMBL3299125	119320	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	441	6	2	3	4.6	O=C(NCCO)c1cccc(-c2cccc3c2CC(Cc2cccc(C(F)(F)F)c2)O3)c1	10.1021/jm5002919
	162659255	188011	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	504	8	2	6	3.3	O=C(c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1)N(CCO)CCO	10.1021/acs.jmedchem.0c01498
	CHEMBL4761550	188011	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	504	8	2	6	3.3	O=C(c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1)N(CCO)CCO	10.1021/acs.jmedchem.0c01498
	137653669	165344	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	365	5	1	4	4.2	Cc1cc(-c2sc(Cc3cccc(N(C)C)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4091718	165344	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	365	5	1	4	4.2	Cc1cc(-c2sc(Cc3cccc(N(C)C)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653555	192886	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	411	4	1	3	4.7	CNC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4871721	192886	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	411	4	1	3	4.7	CNC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	162662957	188698	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccccc2C(F)(F)F)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4779620	188698	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccccc2C(F)(F)F)ncn1	10.1021/acs.jmedchem.0c01498
	122653438	192301	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4862739	192301	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	54670452	164365	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	390	4	1	3	5.1	Cc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4080724	164365	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	390	4	1	3	5.1	Cc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	56649300	164550	30	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4082756	164550	30	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	162670049	189485	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	5	4.0	Cc1c(Cc2cc(F)cc(C(F)(F)F)c2)cnnc1N1CCc2c(C(=O)NCCO)cccc21	10.1021/acs.jmedchem.0c01498
	CHEMBL4789517	189485	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	5	4.0	Cc1c(Cc2cc(F)cc(C(F)(F)F)c2)cnnc1N1CCc2c(C(=O)NCCO)cccc21	10.1021/acs.jmedchem.0c01498
	162668520	189412	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	472	4	1	5	3.7	O=C(c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1)N1CC(O)C1	10.1021/acs.jmedchem.0c01498
	CHEMBL4788591	189412	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	472	4	1	5	3.7	O=C(c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1)N1CC(O)C1	10.1021/acs.jmedchem.0c01498
	122653533	192725	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	465	10	2	6	3.3	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCOCCO)cccc43)c2)cc1F	nan
	CHEMBL4869490	192725	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	465	10	2	6	3.3	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCOCCO)cccc43)c2)cc1F	nan
	118798887	193027	22	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	6	2	4	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4873666	193027	22	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	6	2	4	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653606	191289	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	411	4	1	3	4.8	Cc1cc(Cc2cccc(C(F)(F)F)c2)cc(N2CCc3c(C(N)=O)cccc32)n1	nan
	CHEMBL4847476	191289	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	411	4	1	3	4.8	Cc1cc(Cc2cccc(C(F)(F)F)c2)cc(N2CCc3c(C(N)=O)cccc32)n1	nan
	59193906	119194	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	453	6	2	3	5.7	Cc1c(Cc2cccc(C(F)(F)F)c2)oc2c(-c3cccc(C(=O)NCCO)c3)cccc12	10.1021/jm5002919
	CHEMBL3297809	119194	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	453	6	2	3	5.7	Cc1c(Cc2cccc(C(F)(F)F)c2)oc2c(-c3cccc(C(=O)NCCO)c3)cccc12	10.1021/jm5002919
	137660928	166079	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	404	5	1	3	5.4	CCc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4099668	166079	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	404	5	1	3	5.4	CCc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	44816186	119223	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	486	6	2	3	5.5	NC(=O)CNC(=O)c1cccc(-c2ccc(F)c3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3298234	119223	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	486	6	2	3	5.5	NC(=O)CNC(=O)c1cccc(-c2ccc(F)c3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	162647487	186724	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	434	8	2	7	2.5	COc1cc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)cc(OC)c1	10.1021/acs.jmedchem.0c01498
	CHEMBL4746394	186724	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	434	8	2	7	2.5	COc1cc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)cc(OC)c1	10.1021/acs.jmedchem.0c01498
	70922568	171816	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	445	6	2	5	4.4	O=C(NCCO)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1016/j.bmc.2018.02.005
	CHEMBL4226225	171816	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	445	6	2	5	4.4	O=C(NCCO)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1016/j.bmc.2018.02.005
	69921357	172004	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	7	1	5	5.4	COCCNC(=O)c1cn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)nc1C	10.1016/j.bmc.2018.02.005
	CHEMBL4229128	172004	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	7	1	5	5.4	COCCNC(=O)c1cn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)nc1C	10.1016/j.bmc.2018.02.005
	122653711	192195	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	493	7	2	6	4.2	O=C(Nc1cnn(CCO)c1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4861218	192195	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	493	7	2	6	4.2	O=C(Nc1cnn(CCO)c1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653542	192693	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4868910	192693	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	162659193	188001	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	388	6	2	5	2.8	Cc1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	CHEMBL4761381	188001	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	388	6	2	5	2.8	Cc1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	56649300	164550	30	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Affinity Phenotypic Cellular interaction (Alphascreen (cAMP increase in human GPR52 expressed CHO cell line)) EUB0000317b GPR52Affinity Phenotypic Cellular interaction (Alphascreen (cAMP increase in human GPR52 expressed CHO cell line)) EUB0000317b GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL5209897
	CHEMBL4082756	164550	30	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Affinity Phenotypic Cellular interaction (Alphascreen (cAMP increase in human GPR52 expressed CHO cell line)) EUB0000317b GPR52Affinity Phenotypic Cellular interaction (Alphascreen (cAMP increase in human GPR52 expressed CHO cell line)) EUB0000317b GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL5209897
	162645603	186289	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	402	6	2	5	3.1	Cc1cc(C)cc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	CHEMBL4741200	186289	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	402	6	2	5	3.1	Cc1cc(C)cc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	122653404	193058	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	461	6	2	5	4.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Oc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4874102	193058	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	461	6	2	5	4.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Oc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	162671742	189584	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1cccnc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4790746	189584	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1cccnc1	10.1021/acs.jmedchem.0c01133
	162664350	188948	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	240	5	0	3	2.8	Cn1nccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4782590	188948	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	240	5	0	3	2.8	Cn1nccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162646497	186297	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1ccccc1-c1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4741257	186297	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1ccccc1-c1ccccc1	10.1021/acs.jmedchem.0c01133
	162676088	190102	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1cccc(C(=O)/C=C/CCc2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4797370	190102	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1cccc(C(=O)/C=C/CCc2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	162669764	189347	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	226	5	0	2	3.7	O=C(/C=C/CCc1ccccc1)c1ccoc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4787771	189347	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	226	5	0	2	3.7	O=C(/C=C/CCc1ccccc1)c1ccoc1	10.1021/acs.jmedchem.0c01133
	162648761	186732	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	314	5	0	1	4.8	O=C(/C=C/CCc1ccccc1Br)c1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4746541	186732	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	314	5	0	1	4.8	O=C(/C=C/CCc1ccccc1Br)c1ccccc1	10.1021/acs.jmedchem.0c01133
	162670773	189760	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1ccccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4793323	189760	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1ccccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162673688	189935	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	254	5	0	1	4.2	O=C(/C=C/CCc1ccccc1)c1ccccc1F	10.1021/acs.jmedchem.0c01133
	CHEMBL4795327	189935	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	254	5	0	1	4.2	O=C(/C=C/CCc1ccccc1)c1ccccc1F	10.1021/acs.jmedchem.0c01133
	162659243	187985	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	314	5	0	1	4.8	O=C(/C=C/CCc1ccc(Br)cc1)c1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4761208	187985	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	314	5	0	1	4.8	O=C(/C=C/CCc1ccc(Br)cc1)c1ccccc1	10.1021/acs.jmedchem.0c01133
	162672248	189649	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1ccncc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4791780	189649	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1ccncc1	10.1021/acs.jmedchem.0c01133
	162649157	186619	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1ccccn1	10.1021/acs.jmedchem.0c01133
	CHEMBL4745132	186619	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1ccccn1	10.1021/acs.jmedchem.0c01133
	162664011	188984	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	254	5	0	1	4.2	O=C(/C=C/CCc1ccccc1)c1cccc(F)c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4783011	188984	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	254	5	0	1	4.2	O=C(/C=C/CCc1ccccc1)c1cccc(F)c1	10.1021/acs.jmedchem.0c01133
	162659388	187969	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1cccc(C(=O)/C=C/CCc2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4761078	187969	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1cccc(C(=O)/C=C/CCc2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	162648653	186687	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1ccccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4746014	186687	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1ccccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162661330	188179	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	264	5	0	1	4.7	Cc1cccc(C)c1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4763588	188179	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	264	5	0	1	4.7	Cc1cccc(C)c1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162644983	186239	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1ccc(C(=O)/C=C/CCc2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4740701	186239	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1ccc(C(=O)/C=C/CCc2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	162650192	186921	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	286	5	0	1	5.2	O=C(/C=C/CCc1ccccc1)c1cccc2ccccc12	10.1021/acs.jmedchem.0c01133
	CHEMBL4748854	186921	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	286	5	0	1	5.2	O=C(/C=C/CCc1ccccc1)c1cccc2ccccc12	10.1021/acs.jmedchem.0c01133
	58517179	188554	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	286	5	0	1	5.2	O=C(/C=C/CCc1ccccc1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4777734	188554	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	286	5	0	1	5.2	O=C(/C=C/CCc1ccccc1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.0c01133
	162660152	188115	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1ccc(C(=O)/C=C/CCc2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4762863	188115	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1ccc(C(=O)/C=C/CCc2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	5316932	98319	24	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	264	7	0	1	4.4	O=C(/C=C/CCc1ccccc1)CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL240484	98319	24	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	264	7	0	1	4.4	O=C(/C=C/CCc1ccccc1)CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162662933	188793	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	226	5	0	2	3.7	O=C(/C=C/CCc1ccccc1)c1ccco1	10.1021/acs.jmedchem.0c01133
	CHEMBL4780703	188793	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	226	5	0	2	3.7	O=C(/C=C/CCc1ccccc1)c1ccco1	10.1021/acs.jmedchem.0c01133
	10879121	96398	19	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	236	5	0	1	4.1	O=C(/C=C/CCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL2375494	96398	19	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	236	5	0	1	4.1	O=C(/C=C/CCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01133
	162675641	190175	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4798117	190175	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	162656078	187466	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4755423	187466	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	156588927	188927	20	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1cccs1	10.1021/acs.jmedchem.0c01133
	CHEMBL4782344	188927	20	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1cccs1	10.1021/acs.jmedchem.0c01133
	162675368	190072	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1ccsc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4796964	190072	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1ccsc1	10.1021/acs.jmedchem.0c01133
	44623954	7919	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	24884590
	8840	7919	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	24884590
	CHEMBL3299119	7919	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	24884590
	69921479	8153	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	29478803
	9804	8153	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	29478803
	CHEMBL4228912	8153	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	29478803

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		CHEMBL5282094	200922	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	404	3	1	4	3.6	Cc1nn(-c2cncc(Cc3cc(F)cc(C(F)(F)F)c3)c2)c2c1C(=O)NCC2	10.1021/acsmedchemlett.3c00052
		CHEMBL5287006	201149	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2c1cnn2-c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	10.1021/acsmedchemlett.3c00052
		CHEMBL5280513	200852	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2c1cnn2-c1cncc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		CHEMBL5289682	201255	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	389	3	1	3	3.9	O=C1NCCc2c1cnn2-c1cccc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		CHEMBL5287950	201181	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	372	4	1	4	3.2	O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		CHEMBL5277794	200728	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	386	4	1	4	3.5	Cc1nn(-c2ccnc(Cc3cc(F)cc(C(F)F)c3)c2)c2c1C(=O)NCC2	10.1021/acsmedchemlett.3c00052
		CHEMBL5274093	200572	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	404	3	0	4	3.6	CN1CCc2c(cnn2-c2cc(Cc3cc(F)cc(C(F)(F)F)c3)ccn2)C1=O	10.1021/acsmedchemlett.3c00052
		CHEMBL5284809	201045	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	371	3	0	4	4.4	O=C1CCCc2c1cnn2-c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	10.1021/acsmedchemlett.3c00052
		CHEMBL5272124	200488	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	376	3	1	4	3.3	O=C1NCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		CHEMBL5284353	201031	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		CHEMBL5278598	200765	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	404	3	1	4	3.6	Cc1nn(-c2ccnc(Cc3cc(F)cc(C(F)(F)F)c3)c2)c2c1C(=O)NCC2	10.1021/acsmedchemlett.3c00052
		CHEMBL5284353	201031	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		90645439	119314	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin)	ChEMBL	414	8	2	4	3.9	O=C(NCCO)c1cccc(-c2cccc(OCCc3cc(F)cc(Cl)c3)n2)c1	10.1021/jm5002919
		CHEMBL3299118	119314	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin)	ChEMBL	414	8	2	4	3.9	O=C(NCCO)c1cccc(-c2cccc(OCCc3cc(F)cc(Cl)c3)n2)c1	10.1021/jm5002919
		CHEMBL5278255	200751	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	424	3	1	4	4.0	O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)c(Cl)c(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		CHEMBL5273936	200565	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	404	3	1	4	3.7	O=C1NCCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		CHEMBL5291296	201305	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2nn(-c3ccnc(Cc4cc(F)cc(C(F)(F)F)c4)c3)cc21	10.1021/acsmedchemlett.3c00052
		CHEMBL5287320	201159	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	402	5	1	5	3.2	Cc1nn(-c2ccnc(Cc3cc(F)cc(OC(F)F)c3)c2)c2c1C(=O)NCC2	10.1021/acsmedchemlett.3c00052
		CHEMBL5271921	200482	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	372	3	1	4	3.2	O=C1NCCc2c1cnn2-c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	10.1021/acsmedchemlett.3c00052
		CHEMBL5267002	200281	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	391	3	1	5	2.7	O=C1NCCc2c1nnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		44206579	119313	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin)	ChEMBL	430	8	2	4	4.1	O=C(NCCO)c1cccc(-c2cccc(OCCc3cccc(C(F)(F)F)c3)n2)c1	10.1021/jm5002919
		CHEMBL3299117	119313	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin)	ChEMBL	430	8	2	4	4.1	O=C(NCCO)c1cccc(-c2cccc(OCCc3cccc(C(F)(F)F)c3)n2)c1	10.1021/jm5002919
		56649300	164550	30	None	-	0	Mouse	7.2	pEC50	=	7.2	Binding	Agonist activity at mouse GPR52Agonist activity at mouse GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
		CHEMBL4082756	164550	30	None	-	0	Mouse	7.2	pEC50	=	7.2	Binding	Agonist activity at mouse GPR52Agonist activity at mouse GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
		56649300	164550	30	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL5210121
		CHEMBL4082756	164550	30	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL5210121
		CHEMBL5279049	200790	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	372	2	0	6	2.9	C=C1C(=O)O[C@@H]2C/C=C(\C)CC3C=C(C[C@H](OC(=O)/C(C)=C\C)[C@@H]12)C(=O)O3	10.1021/acs.jmedchem.2c00799
		5316932	98319	24	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	264	7	0	1	4.4	O=C(/C=C/CCc1ccccc1)CCc1ccccc1	10.1021/acs.jmedchem.2c00799
		CHEMBL240484	98319	24	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	264	7	0	1	4.4	O=C(/C=C/CCc1ccccc1)CCc1ccccc1	10.1021/acs.jmedchem.2c00799
		156588927	188927	20	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1cccs1	10.1021/acs.jmedchem.2c00799
		CHEMBL4782344	188927	20	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1cccs1	10.1021/acs.jmedchem.2c00799
		10879121	96398	19	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	236	5	0	1	4.1	O=C(/C=C/CCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.2c00799
		CHEMBL2375494	96398	19	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	236	5	0	1	4.1	O=C(/C=C/CCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.2c00799

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Main reference

Ligand source activities (1 row/activity)