Ligand source activities (1 row/activity)





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DOI

162644596 186198 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 2.1 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O nan
CHEMBL4740228 186198 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 2.1 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O nan
153585580 186223 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 411 6 1 8 1.7 COc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 nan
CHEMBL4740491 186223 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 411 6 1 8 1.7 COc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 nan
153585418 186226 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 434 5 1 8 1.4 C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)cnn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4740519 186226 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 434 5 1 8 1.4 C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)cnn2c1=O)c1ccc(Cl)c(F)c1 nan
148659040 186343 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 388 4 1 5 2.4 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(Br)n3c2=O)cc1 nan
CHEMBL4741806 186343 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 388 4 1 5 2.4 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(Br)n3c2=O)cc1 nan
153585598 186394 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 446 5 1 7 1.9 C[C@H](NC(=O)Cn1nc2cccc(N3CCN(C)CC3)n2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4742673 186394 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 446 5 1 7 1.9 C[C@H](NC(=O)Cn1nc2cccc(N3CCN(C)CC3)n2c1=O)c1ccc(Cl)c(F)c1 nan
148397968 186414 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 nan
CHEMBL4742901 186414 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 nan
147048009 186436 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 388 4 1 5 2.4 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(Br)cn3c2=O)cc1 nan
CHEMBL4743199 186436 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 388 4 1 5 2.4 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(Br)cn3c2=O)cc1 nan
147451915 186466 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 348 4 1 5 2.2 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4743612 186466 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 348 4 1 5 2.2 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(F)c1 nan
152956498 186489 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 324 4 1 5 2.2 Cc1ccc([C@H](C)NC(=O)C(C)n2nc3ccccn3c2=O)cc1 nan
CHEMBL4743938 186489 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 324 4 1 5 2.2 Cc1ccc([C@H](C)NC(=O)C(C)n2nc3ccccn3c2=O)cc1 nan
153585490 186520 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ncccn2c1=O nan
CHEMBL4744169 186520 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ncccn2c1=O nan
153585688 186537 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 479 6 2 8 2.2 C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4744340 186537 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 479 6 2 8 2.2 C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
162647825 186614 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 399 5 1 7 1.8 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 nan
CHEMBL4745096 186614 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 399 5 1 7 1.8 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 nan
152005060 186641 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 447 5 1 8 1.3 C[C@H](NC(=O)Cn1nc2c(N3CCN(C)CC3)nccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4745432 186641 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 447 5 1 8 1.3 C[C@H](NC(=O)Cn1nc2c(N3CCN(C)CC3)nccn2c1=O)c1ccc(Cl)c(F)c1 nan
150944515 186643 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 425 5 2 7 3.0 Cc1ccc([C@H](C)NC(=O)Cn2nc3c(NC(=O)OC(C)(C)C)cccn3c2=O)cc1 nan
CHEMBL4745487 186643 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 425 5 2 7 3.0 Cc1ccc([C@H](C)NC(=O)Cn2nc3c(NC(=O)OC(C)(C)C)cccn3c2=O)cc1 nan
147626442 186658 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 395 5 1 7 2.0 Cc1cn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2cn1 nan
CHEMBL4745668 186658 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 395 5 1 7 2.0 Cc1cn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2cn1 nan
150995037 186698 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 349 4 1 6 1.6 C[C@H](NC(=O)Cn1nc2cnccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4746108 186698 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 349 4 1 6 1.6 C[C@H](NC(=O)Cn1nc2cnccn2c1=O)c1ccc(Cl)c(F)c1 nan
162648023 186754 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 452 7 2 9 1.5 C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4746822 186754 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 452 7 2 9 1.5 C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
153585512 186807 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 367 4 1 6 1.7 C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4747431 186807 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 367 4 1 6 1.7 C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)c(F)c1 nan
162650006 186904 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2cccnn2c1=O nan
CHEMBL4748681 186904 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2cccnn2c1=O nan
153585452 186990 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 349 4 1 6 1.6 C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)cc1 nan
CHEMBL4749705 186990 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 349 4 1 6 1.6 C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)cc1 nan
151976938 187019 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 310 4 1 5 1.7 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 nan
CHEMBL4750143 187019 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 310 4 1 5 1.7 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 nan
147634500 187057 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F nan
CHEMBL4750692 187057 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F nan
149094095 187061 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 421 6 1 7 2.5 C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4750718 187061 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 421 6 1 7 2.5 C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
152023194 187109 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 344 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nc3c(Cl)cccn3c2=O)cc1 nan
CHEMBL4751203 187109 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 344 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nc3c(Cl)cccn3c2=O)cc1 nan
153585601 187116 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 478 6 1 8 2.0 C[C@H](NC(=O)Cn1nc2cccc(N3CCN(C)CC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4751259 187116 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 478 6 1 8 2.0 C[C@H](NC(=O)Cn1nc2cccc(N3CCN(C)CC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 nan
153585718 187120 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 373 4 1 6 2.0 C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4751304 187120 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 373 4 1 6 2.0 C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 nan
153585541 187160 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 341 5 1 7 1.1 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2n1 nan
CHEMBL4751720 187160 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 341 5 1 7 1.1 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2n1 nan
153585550 187172 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 355 5 1 6 1.8 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(C2CC2)c(F)c1 nan
CHEMBL4751886 187172 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 355 5 1 6 1.8 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(C2CC2)c(F)c1 nan
153585655 187255 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 493 7 1 8 2.9 COC1CCN(c2ccn3c(=O)n(CC(=O)N[C@@H](C)c4ccc(OC(F)(F)F)cc4)nc3c2)CC1 nan
CHEMBL4752993 187255 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 493 7 1 8 2.9 COC1CCN(c2ccn3c(=O)n(CC(=O)N[C@@H](C)c4ccc(OC(F)(F)F)cc4)nc3c2)CC1 nan
147378727 187306 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 380 6 1 6 2.1 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)c(F)c1 nan
CHEMBL4753547 187306 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 380 6 1 6 2.1 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)c(F)c1 nan
162653797 187309 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 329 4 1 6 1.2 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F nan
CHEMBL4753587 187309 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 329 4 1 6 1.2 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F nan
150050373 187374 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 339 4 1 6 1.7 Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(C)nc(C)n3c2=O)cc1 nan
CHEMBL4754384 187374 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 339 4 1 6 1.7 Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(C)nc(C)n3c2=O)cc1 nan
149101043 187382 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 415 5 1 7 2.3 C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4754476 187382 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 415 5 1 7 2.3 C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
153585478 187384 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 479 6 2 8 2.2 C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4754503 187384 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 479 6 2 8 2.2 C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
153585445 187536 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 382 4 1 5 2.5 C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(C(F)(F)F)cc1 nan
CHEMBL4756137 187536 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 382 4 1 5 2.5 C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(C(F)(F)F)cc1 nan
153585588 187565 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 444 5 2 7 1.7 C[C@H](NC(=O)Cn1nc2c(N3CCC34CNC4)cccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4756392 187565 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 444 5 2 7 1.7 C[C@H](NC(=O)Cn1nc2c(N3CCC34CNC4)cccn2c1=O)c1ccc(Cl)c(F)c1 nan
153585712 187570 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 419 6 2 7 2.0 C[C@H](NC(=O)Cn1nc2cc(NC3COC3)ccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4756431 187570 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 419 6 2 7 2.0 C[C@H](NC(=O)Cn1nc2cc(NC3COC3)ccn2c1=O)c1ccc(Cl)c(F)c1 nan
94095050 187590 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 380 5 1 6 2.3 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4756787 187590 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 380 5 1 6 2.3 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
153585575 187608 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 433 5 2 8 1.0 C[C@H](NC(=O)Cn1nc2c(N3CCNCC3)nccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4756937 187608 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 433 5 2 8 1.0 C[C@H](NC(=O)Cn1nc2c(N3CCNCC3)nccn2c1=O)c1ccc(Cl)c(F)c1 nan
162656575 187662 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 355 5 1 6 1.8 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)c(F)c1 nan
CHEMBL4757480 187662 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 355 5 1 6 1.8 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)c(F)c1 nan
153585415 187667 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 2.1 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O nan
CHEMBL4757506 187667 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 2.1 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O nan
162656504 187675 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 420 6 2 8 1.4 C[C@H](NC(=O)Cn1nc2c(NC3COC3)nccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4757619 187675 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 420 6 2 8 1.4 C[C@H](NC(=O)Cn1nc2c(NC3COC3)nccn2c1=O)c1ccc(Cl)c(F)c1 nan
153585404 187687 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 399 5 1 7 1.8 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 nan
CHEMBL4757742 187687 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 399 5 1 7 1.8 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 nan
149421402 187735 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 452 7 1 8 2.1 C[C@H](NC(=O)Cn1nc2cc(OC3COC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4758375 187735 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 452 7 1 8 2.1 C[C@H](NC(=O)Cn1nc2cc(OC3COC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
162657688 187834 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1cc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)ccc1Cl nan
CHEMBL4759611 187834 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1cc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)ccc1Cl nan
153585534 187863 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 413 5 1 7 2.1 Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 nan
CHEMBL4759991 187863 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 413 5 1 7 2.1 Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 nan
162657416 187899 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 nan
CHEMBL4760528 187899 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 nan
153585663 187934 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1Cl nan
CHEMBL4760812 187934 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1Cl nan
153585574 188000 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 2.1 C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4761321 188000 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 2.1 C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 nan
162660420 188054 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 5 1 6 2.0 CC[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4762121 188054 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 5 1 6 2.0 CC[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 nan
147987797 188063 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 364 4 1 5 2.4 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 nan
CHEMBL4762206 188063 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 364 4 1 5 2.4 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 nan
153585643 188120 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 381 5 1 7 1.7 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4762957 188120 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 381 5 1 7 1.7 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
147323186 188163 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 325 4 1 6 1.4 Cc1ccc([C@H](C)NC(=O)Cn2nc3cnc(C)cn3c2=O)cc1 nan
CHEMBL4763362 188163 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 325 4 1 6 1.4 Cc1ccc([C@H](C)NC(=O)Cn2nc3cnc(C)cn3c2=O)cc1 nan
153585610 188224 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 344 4 1 5 2.3 Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O nan
CHEMBL4764290 188224 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 344 4 1 5 2.3 Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O nan
162661581 188243 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 362 4 1 5 2.7 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O nan
CHEMBL4764506 188243 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 362 4 1 5 2.7 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O nan
153585681 188262 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 399 5 1 7 1.8 C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4764666 188262 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 399 5 1 7 1.8 C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
152494840 188276 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 479 6 2 8 2.2 C[C@H](NC(=O)Cn1nc2cc(N3CCC(O)CC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4764839 188276 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 479 6 2 8 2.2 C[C@H](NC(=O)Cn1nc2cc(N3CCC(O)CC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
134043805 188548 1 None 3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 362 6 1 6 2.0 CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 nan
CHEMBL4777673 188548 1 None 3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 362 6 1 6 2.0 CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 nan
162665057 188845 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 365 4 1 6 2.1 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 nan
CHEMBL4781404 188845 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 365 4 1 6 2.1 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 nan
149618414 189040 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 325 4 2 6 1.3 Cc1ccc([C@H](C)NC(=O)Cn2nc3c(N)cccn3c2=O)cc1 nan
CHEMBL4783739 189040 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 325 4 2 6 1.3 Cc1ccc([C@H](C)NC(=O)Cn2nc3c(N)cccn3c2=O)cc1 nan
153585453 189047 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 431 6 1 7 2.6 C[C@H](NC(=O)Cn1nc2c(C(F)F)nccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4783815 189047 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 431 6 1 7 2.6 C[C@H](NC(=O)Cn1nc2c(C(F)F)nccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
153585542 189085 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 365 4 1 6 2.1 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(Cl)c1 nan
CHEMBL4784153 189085 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 365 4 1 6 2.1 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(Cl)c1 nan
151570395 189166 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 340 5 1 6 1.7 COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n2c1 nan
CHEMBL4785283 189166 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 340 5 1 6 1.7 COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n2c1 nan
153585417 189206 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1Cl nan
CHEMBL4785963 189206 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1Cl nan
162667558 189241 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 331 4 1 6 1.4 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)cc1 nan
CHEMBL4786371 189241 0 None 10 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 331 4 1 6 1.4 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)cc1 nan
153585609 189251 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 465 6 1 8 2.1 C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4786573 189251 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 465 6 1 8 2.1 C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
151394869 189315 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 349 4 1 6 1.6 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4787308 189315 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 349 4 1 6 1.6 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 nan
151043804 189454 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 349 4 1 6 1.6 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4789123 189454 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 349 4 1 6 1.6 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 nan
162670176 189530 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 377 5 1 6 2.2 CC(C)[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4790080 189530 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 377 5 1 6 2.2 CC(C)[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 nan
150234341 189569 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 395 5 1 7 2.0 Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 nan
CHEMBL4790498 189569 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 395 5 1 7 2.0 Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 nan
149881970 189633 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 395 5 1 7 2.0 Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2n1 nan
CHEMBL4791551 189633 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 395 5 1 7 2.0 Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2n1 nan
149784975 189657 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 311 4 1 6 1.1 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccncn3c2=O)cc1 nan
CHEMBL4791843 189657 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 311 4 1 6 1.1 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccncn3c2=O)cc1 nan
162670473 189689 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 395 5 1 7 2.0 Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 nan
CHEMBL4792356 189689 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 395 5 1 7 2.0 Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 nan
153585679 189702 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 329 4 1 6 1.2 Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F nan
CHEMBL4792515 189702 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 329 4 1 6 1.2 Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F nan
162671011 189723 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 nan
CHEMBL4792732 189723 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 nan
153585435 189773 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 359 4 1 6 2.0 Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 nan
CHEMBL4793463 189773 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 359 4 1 6 2.0 Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 nan
153585524 189909 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 328 4 1 5 1.8 Cc1ccc([C@H](C)NC(=O)Cn2nc3c(F)cccn3c2=O)cc1 nan
CHEMBL4795078 189909 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 328 4 1 5 1.8 Cc1ccc([C@H](C)NC(=O)Cn2nc3c(F)cccn3c2=O)cc1 nan
153585386 190012 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 415 5 1 7 2.3 C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4796254 190012 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 415 5 1 7 2.3 C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
153585438 190139 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2c1 nan
CHEMBL4797724 190139 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2c1 nan
153585532 190171 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 328 4 1 5 1.8 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 nan
CHEMBL4798029 190171 0 None -3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 328 4 1 5 1.8 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 nan
162675990 190197 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 375 5 1 6 2.0 O=C(Cn1nc2cccnn2c1=O)N[C@H](c1ccc(Cl)c(F)c1)C1CC1 nan
CHEMBL4798509 190197 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 375 5 1 6 2.0 O=C(Cn1nc2cccnn2c1=O)N[C@H](c1ccc(Cl)c(F)c1)C1CC1 nan
153585488 190246 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 395 5 1 7 2.0 Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 nan
CHEMBL4799144 190246 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 395 5 1 7 2.0 Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 nan
153585707 190357 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 361 5 1 7 1.4 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 nan
CHEMBL4800487 190357 0 None 1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 361 5 1 7 1.4 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 nan
153585650 186183 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 381 5 1 7 1.7 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4740004 186183 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 381 5 1 7 1.7 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
162644596 186198 0 None 1 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 2.1 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O nan
CHEMBL4740228 186198 0 None 1 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 2.1 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O nan
162648528 186593 0 None 1 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 337 5 1 6 1.6 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)cc1 nan
CHEMBL4744984 186593 0 None 1 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 337 5 1 6 1.6 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)cc1 nan
146867363 186655 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 465 7 1 8 2.0 C[C@H](NC(=O)Cn1nc2cc(OC3CN(C)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4745642 186655 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 465 7 1 8 2.0 C[C@H](NC(=O)Cn1nc2cc(OC3CN(C)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
162649809 186824 0 None 1 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 458 5 1 7 2.1 C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4747632 186824 0 None 1 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 458 5 1 7 2.1 C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 nan
153585543 187015 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 311 4 1 6 1.1 Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1 nan
CHEMBL4750043 187015 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 311 4 1 6 1.1 Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1 nan
153585514 187152 0 None -10 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 311 4 1 6 1.1 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1 nan
CHEMBL4751629 187152 0 None -10 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 311 4 1 6 1.1 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1 nan
153585659 187411 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 381 6 1 7 1.5 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)F)c(F)c1 nan
CHEMBL4754933 187411 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 381 6 1 7 1.5 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)F)c(F)c1 nan
153585592 187522 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 464 6 2 8 1.7 C[C@H](NC(=O)Cn1nc2cccc(N3CCNCC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4755986 187522 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 464 6 2 8 1.7 C[C@H](NC(=O)Cn1nc2cccc(N3CCNCC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 nan
133916051 188028 1 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 356 5 1 5 2.4 O=C(Cn1nc2ccccn2c1=O)NC(c1ccc(Cl)cc1)C1CC1 nan
CHEMBL4761733 188028 1 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 356 5 1 5 2.4 O=C(Cn1nc2ccccn2c1=O)NC(c1ccc(Cl)cc1)C1CC1 nan
153065968 188057 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 354 6 1 6 2.2 CC(C)Oc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 nan
CHEMBL4762154 188057 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 354 6 1 6 2.2 CC(C)Oc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 nan
153585680 188065 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 314 4 1 5 1.5 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(F)cc1 nan
CHEMBL4762210 188065 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 314 4 1 5 1.5 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(F)cc1 nan
151392727 188502 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 464 6 1 8 2.7 C[C@H](NC(=O)Cn1nc2ccc(N3CCCCC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4777046 188502 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 464 6 1 8 2.7 C[C@H](NC(=O)Cn1nc2ccc(N3CCCCC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
134043805 188548 1 None 3 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 362 6 1 6 2.0 CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 nan
CHEMBL4777673 188548 1 None 3 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 362 6 1 6 2.0 CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 nan
153585533 188830 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 372 5 1 5 3.0 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(-c2ccccc2)cc1 nan
CHEMBL4781160 188830 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 372 5 1 5 3.0 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(-c2ccccc2)cc1 nan
153585698 189200 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 331 4 1 6 1.4 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)cc1 nan
CHEMBL4785855 189200 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 331 4 1 6 1.4 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)cc1 nan
149374815 189280 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 311 4 1 6 1.1 Cc1ccc([C@H](C)NC(=O)Cn2nc3cnccn3c2=O)cc1 nan
CHEMBL4786952 189280 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 311 4 1 6 1.1 Cc1ccc([C@H](C)NC(=O)Cn2nc3cnccn3c2=O)cc1 nan
153585657 189349 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 360 4 1 5 2.1 O=C(Cn1nc2ccc(F)cn2c1=O)NC1(c2ccc(Cl)cc2)CC1 nan
CHEMBL4787820 189349 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 360 4 1 5 2.1 O=C(Cn1nc2ccc(F)cn2c1=O)NC1(c2ccc(Cl)cc2)CC1 nan
121349628 188804 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 10.1021/acs.jmedchem.1c00820
121349628 188804 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 nan
CHEMBL4780801 188804 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 10.1021/acs.jmedchem.1c00820
CHEMBL4780801 188804 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 nan
121349739 188949 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 392 6 1 6 2.4 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)F)cc1 nan
CHEMBL4782619 188949 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 392 6 1 6 2.4 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)F)cc1 nan
121349631 189261 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 nan
CHEMBL4786722 189261 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 nan
122195502 130895 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 402 8 2 3 3.9 COc1cccc(C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/acsmedchemlett.5b00247
CHEMBL3633717 130895 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 402 8 2 3 3.9 COc1cccc(C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/acsmedchemlett.5b00247
121349564 188543 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349564 188543 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 nan
CHEMBL4777630 188543 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4777630 188543 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 nan
121349633 189496 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O nan
CHEMBL4789631 189496 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O nan
164628435 193069 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 322 4 1 5 2.0 Cc1cccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c1 10.1021/acs.jmedchem.1c00820
CHEMBL4874254 193069 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 322 4 1 5 2.0 Cc1cccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c1 10.1021/acs.jmedchem.1c00820
26532940 130898 1 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 316 5 2 2 2.9 C[C@H](NC(=O)CNC(=O)c1ccc(Cl)cc1)c1ccccc1 10.1021/acsmedchemlett.5b00247
CHEMBL3633721 130898 1 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 316 5 2 2 2.9 C[C@H](NC(=O)CNC(=O)c1ccc(Cl)cc1)c1ccccc1 10.1021/acsmedchemlett.5b00247
164621186 192873 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 323 4 0 6 2.4 Cc1ccc([C@H](C)OC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4871591 192873 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 323 4 0 6 2.4 Cc1ccc([C@H](C)OC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349572 188625 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 356 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 nan
CHEMBL4778561 188625 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 356 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 nan
121349566 189431 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 372 5 1 6 2.3 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 nan
CHEMBL4788831 189431 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 372 5 1 6 2.3 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 nan
121349806 190153 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 394 4 1 5 2.8 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(C(F)(F)F)cc1 nan
CHEMBL4797857 190153 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 394 4 1 5 2.8 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(C(F)(F)F)cc1 nan
2114212 27702 14 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 308 5 1 5 1.2 O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1 10.1021/acs.jmedchem.1c00820
CHEMBL1310918 27702 14 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 308 5 1 5 1.2 O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1 10.1021/acs.jmedchem.1c00820
121349764 189667 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 360 4 1 5 2.5 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1Cl nan
CHEMBL4792090 189667 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 360 4 1 5 2.5 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1Cl nan
36428174 188721 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 376 4 1 5 2.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4779855 188721 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 376 4 1 5 2.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.1c00820
121349734 188875 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 nan
CHEMBL4781729 188875 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 nan
121349683 189502 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 406 5 1 6 2.7 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c12 nan
CHEMBL4789720 189502 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 406 5 1 6 2.7 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c12 nan
121349710 189727 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 406 5 1 6 2.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 nan
CHEMBL4792828 189727 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 406 5 1 6 2.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 nan
121349767 190109 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 354 4 1 5 2.4 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4797410 190109 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 354 4 1 5 2.4 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
2303171 130897 1 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 316 5 2 2 2.9 C[C@H](NC(=O)CNC(=O)c1ccccc1Cl)c1ccccc1 10.1021/acsmedchemlett.5b00247
CHEMBL3633719 130897 1 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 316 5 2 2 2.9 C[C@H](NC(=O)CNC(=O)c1ccccc1Cl)c1ccccc1 10.1021/acsmedchemlett.5b00247
121349643 190225 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 404 4 1 5 2.6 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1Br nan
CHEMBL4798899 190225 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 404 4 1 5 2.6 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1Br nan
164611430 192003 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 377 4 1 6 2.1 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cn1 10.1021/acs.jmedchem.1c00820
CHEMBL4857947 192003 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 377 4 1 6 2.1 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cn1 10.1021/acs.jmedchem.1c00820
121349781 188627 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 nan
CHEMBL4778563 188627 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 nan
121349675 188744 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 390 4 1 5 3.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 nan
CHEMBL4780038 188744 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 390 4 1 5 3.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 nan
121349763 189247 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 366 5 1 6 2.5 COc1cc(C)ccc1[C@H](C)NC(=O)[C@@H](C)n1nnc2ccccc2c1=O nan
CHEMBL4786501 189247 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 366 5 1 6 2.5 COc1cc(C)ccc1[C@H](C)NC(=O)[C@@H](C)n1nnc2ccccc2c1=O nan
121349809 189940 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 356 5 1 6 1.8 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 nan
CHEMBL4795372 189940 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 356 5 1 6 1.8 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 nan
121349689 189998 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 372 5 1 6 2.3 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 nan
CHEMBL4796061 189998 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 372 5 1 6 2.3 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 nan
2548547 8930 45 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 316 5 2 2 2.9 O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl 10.1021/acsmedchemlett.5b00247
8766 8930 45 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 316 5 2 2 2.9 O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl 10.1021/acsmedchemlett.5b00247
CHEMBL3633720 8930 45 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 316 5 2 2 2.9 O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl 10.1021/acsmedchemlett.5b00247
1555702 130896 2 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 282 5 2 2 2.3 C[C@H](NC(=O)CNC(=O)c1ccccc1)c1ccccc1 10.1021/acsmedchemlett.5b00247
CHEMBL3633718 130896 2 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 282 5 2 2 2.3 C[C@H](NC(=O)CNC(=O)c1ccccc1)c1ccccc1 10.1021/acsmedchemlett.5b00247
121349597 188590 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 356 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(Cl)ccc3c2=O)cc1 nan
CHEMBL4778124 188590 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 356 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(Cl)ccc3c2=O)cc1 nan
121349786 189032 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 404 7 1 7 2.3 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 nan
CHEMBL4783626 189032 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 404 7 1 7 2.3 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 nan
28918448 130917 3 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 312 6 2 3 2.3 COc1cccc(C(=O)NCC(=O)N[C@H](C)c2ccccc2)c1 10.1021/acsmedchemlett.5b00247
CHEMBL3633895 130917 3 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 312 6 2 3 2.3 COc1cccc(C(=O)NCC(=O)N[C@H](C)c2ccccc2)c1 10.1021/acsmedchemlett.5b00247
121349574 189598 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 374 6 1 6 2.3 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 10.1021/acs.jmedchem.1c00820
121349574 189598 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 374 6 1 6 2.3 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 nan
CHEMBL4790968 189598 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 374 6 1 6 2.3 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4790968 189598 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 374 6 1 6 2.3 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 nan
121349782 189823 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 406 5 1 6 2.7 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c2c1 nan
CHEMBL4794046 189823 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 406 5 1 6 2.7 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c2c1 nan
121349740 188870 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 nan
CHEMBL4781651 188870 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 nan
121349745 188991 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 10.1021/acs.jmedchem.1c00820
121349745 188991 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 nan
CHEMBL4783071 188991 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 10.1021/acs.jmedchem.1c00820
CHEMBL4783071 188991 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 nan
121349593 189652 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 394 4 1 5 2.8 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F 10.1021/acs.jmedchem.1c00820
CHEMBL4791792 189652 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 394 4 1 5 2.8 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F 10.1021/acs.jmedchem.1c00820
40719079 130909 1 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 350 5 2 2 3.6 C[C@H](NC(=O)CNC(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
CHEMBL3633885 130909 1 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 350 5 2 2 3.6 C[C@H](NC(=O)CNC(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
121349656 190268 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 424 5 1 6 2.8 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3F)c(=O)c12 nan
CHEMBL4799483 190268 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 424 5 1 6 2.8 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3F)c(=O)c12 nan
121349786 189032 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 404 7 1 7 2.3 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 10.1021/acs.jmedchem.1c00820
CHEMBL4783626 189032 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 404 7 1 7 2.3 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 10.1021/acs.jmedchem.1c00820
121349593 189652 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 394 4 1 5 2.8 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F nan
CHEMBL4791792 189652 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 394 4 1 5 2.8 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F nan
2695546 192895 12 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 342 5 1 5 1.8 O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(Cl)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4871792 192895 12 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 342 5 1 5 1.8 O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(Cl)cc1 10.1021/acs.jmedchem.1c00820
2548543 130918 2 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 316 5 2 2 2.9 C[C@@H](NC(=O)CNC(=O)c1cccc(Cl)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
CHEMBL3633896 130918 2 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 316 5 2 2 2.9 C[C@@H](NC(=O)CNC(=O)c1cccc(Cl)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
11685 10911 25 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 10.1021/acs.jmedchem.1c00820
11685 10911 25 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 nan
121349608 10911 25 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 10.1021/acs.jmedchem.1c00820
121349608 10911 25 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 nan
CHEMBL4779773 10911 25 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 10.1021/acs.jmedchem.1c00820
CHEMBL4779773 10911 25 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 nan
2714485 189721 2 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 326 4 1 5 1.8 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1 nan
CHEMBL4792727 189721 2 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 326 4 1 5 1.8 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1 nan
121349719 190038 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 422 6 1 7 2.6 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 10.1021/acs.jmedchem.1c00820
121349719 190038 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 422 6 1 7 2.6 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 nan
CHEMBL4796493 190038 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 422 6 1 7 2.6 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 10.1021/acs.jmedchem.1c00820
CHEMBL4796493 190038 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 422 6 1 7 2.6 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 nan
8036946 190218 2 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 342 4 1 5 2.3 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4798779 190218 2 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 342 4 1 5 2.3 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 10.1021/acs.jmedchem.1c00820
121349614 188444 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 354 4 1 5 2.4 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(C)c1 nan
CHEMBL4776329 188444 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 354 4 1 5 2.4 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(C)c1 nan
27783537 188462 1 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 386 4 1 5 2.4 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 nan
CHEMBL4776509 188462 1 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 386 4 1 5 2.4 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 nan
121349728 188595 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 10.1021/acs.jmedchem.1c00820
121349728 188595 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 nan
CHEMBL4778172 188595 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 10.1021/acs.jmedchem.1c00820
CHEMBL4778172 188595 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 nan
41757362 188992 1 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 6 1 6 2.1 CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 nan
CHEMBL4783081 188992 1 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 6 1 6 2.1 CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 nan
121349658 189482 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 10.1021/acs.jmedchem.1c00820
CHEMBL4789475 189482 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 10.1021/acs.jmedchem.1c00820
27785340 190250 1 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 322 4 1 5 2.0 Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O 10.1021/acs.jmedchem.1c00820
CHEMBL4799237 190250 1 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 322 4 1 5 2.0 Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O 10.1021/acs.jmedchem.1c00820
27754276 192710 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 336 5 1 5 2.4 CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4869182 192710 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 336 5 1 5 2.4 CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C)cc1 10.1021/acs.jmedchem.1c00820
7534868 130902 2 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 296 5 2 2 2.6 Cc1cccc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 10.1021/acsmedchemlett.5b00247
CHEMBL3633878 130902 2 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 296 5 2 2 2.6 Cc1cccc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 10.1021/acsmedchemlett.5b00247
122195644 130912 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 334 5 2 2 3.1 C[C@H](NC(=O)CNC(=O)c1cc(F)cc(Cl)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
CHEMBL3633888 130912 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 334 5 2 2 3.1 C[C@H](NC(=O)CNC(=O)c1cc(F)cc(Cl)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
121349701 188723 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 422 6 1 7 2.6 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc12 nan
CHEMBL4779884 188723 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 422 6 1 7 2.6 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc12 nan
121349805 189899 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(OC)c3c2=O)cc1 nan
CHEMBL4794908 189899 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(OC)c3c2=O)cc1 nan
121349755 188582 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 356 5 1 6 1.8 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 nan
CHEMBL4778062 188582 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 356 5 1 6 1.8 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 nan
121349734 188875 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 10.1021/acs.jmedchem.1c00820
CHEMBL4781729 188875 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 10.1021/acs.jmedchem.1c00820
27785340 190250 1 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 322 4 1 5 2.0 Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O nan
CHEMBL4799237 190250 1 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 322 4 1 5 2.0 Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O nan
122195501 130894 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 342 7 3 4 1.7 COc1cccc(C(=O)N[C@@H](CO)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/acsmedchemlett.5b00247
CHEMBL3633716 130894 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 342 7 3 4 1.7 COc1cccc(C(=O)N[C@@H](CO)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/acsmedchemlett.5b00247
8036887 191519 1 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 322 5 1 5 1.7 C[C@@H](CNC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 10.1021/acs.jmedchem.1c00820
CHEMBL4850747 191519 1 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 322 5 1 5 1.7 C[C@@H](CNC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 10.1021/acs.jmedchem.1c00820
121349639 189196 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 410 5 1 6 2.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F 10.1021/acs.jmedchem.1c00820
121349639 189196 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 410 5 1 6 2.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F nan
CHEMBL4785741 189196 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 410 5 1 6 2.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F 10.1021/acs.jmedchem.1c00820
CHEMBL4785741 189196 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 410 5 1 6 2.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F nan
3341369 54419 7 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 328 4 1 5 1.8 O=C(Cn1nnc2ccccc2c1=O)NCc1ccc(Cl)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL1546963 54419 7 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 328 4 1 5 1.8 O=C(Cn1nnc2ccccc2c1=O)NCc1ccc(Cl)cc1 10.1021/acs.jmedchem.1c00820
121349694 188994 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 10.1021/acs.jmedchem.1c00820
121349694 188994 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 nan
CHEMBL4783106 188994 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 10.1021/acs.jmedchem.1c00820
CHEMBL4783106 188994 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 nan
121349596 190220 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 322 4 1 5 2.0 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4798863 190220 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 322 4 1 5 2.0 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
164609046 191264 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 336 4 1 5 2.5 Cc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4847108 191264 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 336 4 1 5 2.5 Cc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349780 193148 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 322 5 1 5 1.5 Cc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4875522 193148 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 322 5 1 5 1.5 Cc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349738 188876 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 390 5 1 5 3.1 CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 nan
CHEMBL4781754 188876 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 390 5 1 5 3.1 CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 nan
121349572 188625 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 356 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4778561 188625 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 356 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
2109722 130914 2 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 342 7 2 4 2.3 COc1cc(OC)cc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 10.1021/acsmedchemlett.5b00247
CHEMBL3633890 130914 2 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 342 7 2 4 2.3 COc1cc(OC)cc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 10.1021/acsmedchemlett.5b00247
121349658 189482 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 nan
CHEMBL4789475 189482 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 nan
121349548 190208 1 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 338 5 1 6 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4798667 190208 1 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 338 5 1 6 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
8036946 190218 2 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 342 4 1 5 2.3 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 nan
CHEMBL4798779 190218 2 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 342 4 1 5 2.3 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 nan
26810968 193062 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 358 4 1 5 2.8 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1cccc2ccccc12 10.1021/acs.jmedchem.1c00820
CHEMBL4874147 193062 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 358 4 1 5 2.8 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1cccc2ccccc12 10.1021/acs.jmedchem.1c00820
28918445 130905 1 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 312 6 2 3 2.3 COc1cccc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 10.1021/acsmedchemlett.5b00247
CHEMBL3633881 130905 1 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 312 6 2 3 2.3 COc1cccc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 10.1021/acsmedchemlett.5b00247
121349633 189496 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O 10.1021/acs.jmedchem.1c00820
CHEMBL4789631 189496 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O 10.1021/acs.jmedchem.1c00820
121349767 190109 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 354 4 1 5 2.4 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 nan
CHEMBL4797410 190109 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 354 4 1 5 2.4 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 nan
121349559 188615 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 422 6 1 7 2.6 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc2c1 nan
CHEMBL4778354 188615 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 422 6 1 7 2.6 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc2c1 nan
121349615 189904 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 366 5 1 6 2.3 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 nan
CHEMBL4795005 189904 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 366 5 1 6 2.3 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 nan
121349746 190163 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 390 4 1 5 3.0 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4797979 190163 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 390 4 1 5 3.0 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349645 188497 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 410 5 1 6 2.7 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4776988 188497 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 410 5 1 6 2.7 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1 nan
121349720 189022 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(OC)cccc3c2=O)cc1 nan
CHEMBL4783544 189022 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(OC)cccc3c2=O)cc1 nan
122195642 130910 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 350 5 2 2 3.6 C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)c1ccccc1 10.1021/acsmedchemlett.5b00247
CHEMBL3633886 130910 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 350 5 2 2 3.6 C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)c1ccccc1 10.1021/acsmedchemlett.5b00247
121349688 189677 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 356 5 1 6 1.8 COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 nan
CHEMBL4792174 189677 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 356 5 1 6 1.8 COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 nan
121349659 189044 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 nan
CHEMBL4783774 189044 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 nan
121349600 189364 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 422 6 1 7 2.6 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c2c1 nan
CHEMBL4788013 189364 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 422 6 1 7 2.6 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c2c1 nan
3376937 130915 50 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 365 4 3 4 3.3 COc1cc(OC)cc(C(=O)NNC(=O)Nc2cccc3ccccc23)c1 10.1021/acsmedchemlett.5b00247
CHEMBL3633893 130915 50 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 365 4 3 4 3.3 COc1cc(OC)cc(C(=O)NNC(=O)Nc2cccc3ccccc23)c1 10.1021/acsmedchemlett.5b00247
122195500 130893 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 326 6 2 3 2.7 COc1cccc(C(=O)N[C@H](C)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/acsmedchemlett.5b00247
CHEMBL3633715 130893 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 326 6 2 3 2.7 COc1cccc(C(=O)N[C@H](C)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/acsmedchemlett.5b00247
121349746 190163 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 390 4 1 5 3.0 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 nan
CHEMBL4797979 190163 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 390 4 1 5 3.0 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 nan
2496250 35725 7 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 338 6 1 6 1.2 COc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL1380104 35725 7 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 338 6 1 6 1.2 COc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
122195640 130907 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 366 6 2 3 3.2 C[C@H](NC(=O)CNC(=O)c1cccc(OC(F)(F)F)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
CHEMBL3633883 130907 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 366 6 2 3 3.2 C[C@H](NC(=O)CNC(=O)c1cccc(OC(F)(F)F)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
122195643 130911 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 350 5 2 2 3.6 C[C@H](NC(=O)CNC(=O)c1cc(Cl)cc(Cl)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
CHEMBL3633887 130911 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 350 5 2 2 3.6 C[C@H](NC(=O)CNC(=O)c1cc(Cl)cc(Cl)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
121349558 188751 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 428 5 1 6 2.8 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1F nan
CHEMBL4780121 188751 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 428 5 1 6 2.8 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1F nan
121349685 188912 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 440 6 1 7 2.7 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 nan
CHEMBL4782204 188912 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 440 6 1 7 2.7 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 nan
121349623 188879 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 406 5 1 6 2.7 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc12 nan
CHEMBL4781805 188879 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 406 5 1 6 2.7 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc12 nan
121349588 189015 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 406 6 1 6 3.0 CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4783365 189015 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 406 6 1 6 3.0 CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1 nan
121349773 189207 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 406 5 1 6 2.7 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc2c1 nan
CHEMBL4785980 189207 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 406 5 1 6 2.7 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc2c1 nan
121349793 188602 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 366 5 1 6 2.5 COc1cc(C)ccc1[C@H](C)NC(=O)[C@H](C)n1nnc2ccccc2c1=O nan
CHEMBL4778263 188602 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 366 5 1 6 2.5 COc1cc(C)ccc1[C@H](C)NC(=O)[C@H](C)n1nnc2ccccc2c1=O nan
122195639 130906 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 350 5 2 2 3.3 C[C@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
CHEMBL3633882 130906 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 350 5 2 2 3.3 C[C@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
122195641 130908 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 350 5 2 2 3.6 C[C@H](NC(=O)CNC(=O)c1cccc(Cl)c1Cl)c1ccccc1 10.1021/acsmedchemlett.5b00247
CHEMBL3633884 130908 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 350 5 2 2 3.6 C[C@H](NC(=O)CNC(=O)c1cccc(Cl)c1Cl)c1ccccc1 10.1021/acsmedchemlett.5b00247
2714528 189257 2 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 308 4 1 5 1.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 nan
CHEMBL4786641 189257 2 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 308 4 1 5 1.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 nan
2714527 192184 2 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 308 4 1 5 1.7 C[C@@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 10.1021/acs.jmedchem.1c00820
CHEMBL4861019 192184 2 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 308 4 1 5 1.7 C[C@@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 10.1021/acs.jmedchem.1c00820
121349679 193047 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 6 1 6 1.5 COc1ccc(C[C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4873905 193047 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 6 1 6 1.5 COc1ccc(C[C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
28821961 130904 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 300 5 2 2 2.4 C[C@H](NC(=O)CNC(=O)c1cccc(F)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
CHEMBL3633880 130904 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 300 5 2 2 2.4 C[C@H](NC(=O)CNC(=O)c1cccc(F)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
121349685 188912 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 440 6 1 7 2.7 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 10.1021/acs.jmedchem.1c00820
CHEMBL4782204 188912 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 440 6 1 7 2.7 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 10.1021/acs.jmedchem.1c00820
122195638 130903 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 307 5 2 3 2.2 C[C@H](NC(=O)CNC(=O)c1cccc(C#N)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
CHEMBL3633879 130903 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 307 5 2 3 2.2 C[C@H](NC(=O)CNC(=O)c1cccc(C#N)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
121349795 190228 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 nan
CHEMBL4798933 190228 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 nan
27838947 192210 2 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 342 5 1 5 1.8 O=C(Cn1nnc2ccccc2c1=O)NCCc1cccc(Cl)c1 10.1021/acs.jmedchem.1c00820
CHEMBL4861445 192210 2 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 342 5 1 5 1.8 O=C(Cn1nnc2ccccc2c1=O)NCCc1cccc(Cl)c1 10.1021/acs.jmedchem.1c00820
2998350 44878 6 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 334 3 1 5 2.0 O=C(Cn1nnc2ccccc2c1=O)NC1CCCc2ccccc21 10.1021/acs.jmedchem.1c00820
CHEMBL1460960 44878 6 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 334 3 1 5 2.0 O=C(Cn1nnc2ccccc2c1=O)NC1CCCc2ccccc21 10.1021/acs.jmedchem.1c00820
122195499 130892 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 326 6 2 3 2.7 COc1cccc(C(=O)N[C@@H](C)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/acsmedchemlett.5b00247
CHEMBL3633714 130892 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 326 6 2 3 2.7 COc1cccc(C(=O)N[C@@H](C)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/acsmedchemlett.5b00247
41757362 188992 1 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 6 1 6 2.1 CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4783081 188992 1 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 6 1 6 2.1 CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349753 189673 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 nan
CHEMBL4792136 189673 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 nan
2856847 130916 10 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 299 5 1 3 3.4 CC(NC(=O)CSC(=O)c1ccccc1)c1ccccc1 10.1021/acsmedchemlett.5b00247
CHEMBL3633894 130916 10 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 299 5 1 3 3.4 CC(NC(=O)CSC(=O)c1ccccc1)c1ccccc1 10.1021/acsmedchemlett.5b00247
164619649 192545 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 342 5 1 5 1.8 O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1Cl 10.1021/acs.jmedchem.1c00820
CHEMBL4866435 192545 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 342 5 1 5 1.8 O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1Cl 10.1021/acs.jmedchem.1c00820
121349671 188532 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 350 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 nan
CHEMBL4777495 188532 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 350 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 nan
121349778 189135 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 406 5 1 6 3.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 nan
CHEMBL4784744 189135 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 406 5 1 6 3.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 nan
121349756 189346 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 356 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 nan
CHEMBL4787761 189346 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 356 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 nan
121349555 189416 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 322 4 1 5 2.0 Cc1ccc([C@@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 nan
CHEMBL4788631 189416 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 322 4 1 5 2.0 Cc1ccc([C@@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 nan
121349787 189451 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 nan
CHEMBL4789079 189451 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 nan
121349554 190318 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(OC)ccc3c2=O)cc1 nan
CHEMBL4800089 190318 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(OC)ccc3c2=O)cc1 nan
164617704 191310 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 374 6 1 7 1.4 COc1ccc([C@H](C)NS(=O)(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4847795 191310 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 374 6 1 7 1.4 COc1ccc([C@H](C)NS(=O)(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
164617980 191808 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 377 4 1 6 2.1 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)nc1 10.1021/acs.jmedchem.1c00820
CHEMBL4855076 191808 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 377 4 1 6 2.1 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)nc1 10.1021/acs.jmedchem.1c00820
122195645 130913 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 394 5 2 2 3.7 C[C@H](NC(=O)CNC(=O)c1cc(Cl)cc(Br)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
CHEMBL3633889 130913 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 394 5 2 2 3.7 C[C@H](NC(=O)CNC(=O)c1cc(Cl)cc(Br)c1)c1ccccc1 10.1021/acsmedchemlett.5b00247
78596259 192154 1 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 342 4 1 5 2.3 CC(NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4860510 192154 1 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 342 4 1 5 2.3 CC(NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 10.1021/acs.jmedchem.1c00820
121349587 189191 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 nan
CHEMBL4785669 189191 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 nan
164620660 192724 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 384 6 1 5 2.8 O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(-c2ccccc2)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4869485 192724 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 384 6 1 5 2.8 O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(-c2ccccc2)cc1 10.1021/acs.jmedchem.1c00820
27783537 188462 1 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 386 4 1 5 2.4 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4776509 188462 1 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 386 4 1 5 2.4 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 10.1021/acs.jmedchem.1c00820
121349569 188694 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 nan
CHEMBL4779481 188694 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 nan
121349561 189509 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 nan
CHEMBL4789791 189509 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 nan
121349769 189706 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 nan
CHEMBL4792561 189706 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 nan
121349596 190220 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 322 4 1 5 2.0 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 nan
CHEMBL4798863 190220 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 322 4 1 5 2.0 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 nan
164620725 192864 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.2 COc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4871506 192864 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 352 5 1 6 2.2 COc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
36428174 188721 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 376 4 1 5 2.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 nan
CHEMBL4779855 188721 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 376 4 1 5 2.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 nan
121349753 189673 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 10.1021/acs.jmedchem.1c00820
CHEMBL4792136 189673 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayAgonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 10.1021/acs.jmedchem.1c00820
11685 10911 25 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist-induced <i>in vitro</i> calcium mobilization assay, using CHO-T-REx cells stably expressing hGPR139Agonist-induced <i>in vitro</i> calcium mobilization assay, using CHO-T-REx cells stably expressing hGPR139
Guide to Pharmacology 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 34260228
121349608 10911 25 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist-induced <i>in vitro</i> calcium mobilization assay, using CHO-T-REx cells stably expressing hGPR139Agonist-induced <i>in vitro</i> calcium mobilization assay, using CHO-T-REx cells stably expressing hGPR139
Guide to Pharmacology 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 34260228
CHEMBL4779773 10911 25 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist-induced <i>in vitro</i> calcium mobilization assay, using CHO-T-REx cells stably expressing hGPR139Agonist-induced <i>in vitro</i> calcium mobilization assay, using CHO-T-REx cells stably expressing hGPR139
Guide to Pharmacology 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 34260228
2144 9135 0 None - 1 Human 3.5 pEC50 = 3.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 24826842
3313 9135 0 None - 1 Human 3.5 pEC50 = 3.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 24826842
6140 9135 0 None - 1 Human 3.5 pEC50 = 3.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 24826842
6925665 9135 0 None - 1 Human 3.5 pEC50 = 3.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 24826842
CHEMBL301523 9135 0 None - 1 Human 3.5 pEC50 = 3.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 24826842
DB00120 9135 0 None - 1 Human 3.5 pEC50 = 3.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 24826842
2780 9152 106 None 13 2 Human 3.7 pEC50 = 3.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 24826842
6305 9152 106 None 13 2 Human 3.7 pEC50 = 3.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 24826842
6923516 9152 106 None 13 2 Human 3.7 pEC50 = 3.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 24826842
717 9152 106 None 13 2 Human 3.7 pEC50 = 3.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 24826842
CHEMBL54976 9152 106 None 13 2 Human 3.7 pEC50 = 3.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 24826842
DB00150 9152 106 None 13 2 Human 3.7 pEC50 = 3.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 24826842
7799 7798 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 365 4 3 4 3.3 COc1cc(OC)cc(c1)C(=O)NNC(=O)Nc1ccc2c(c1)cccc2 24900311
86277840 7798 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 365 4 3 4 3.3 COc1cc(OC)cc(c1)C(=O)NNC(=O)Nc1ccc2c(c1)cccc2 24900311
2144 9135 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Drug Central 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 None
3313 9135 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Drug Central 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 None
6140 9135 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Drug Central 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 None
6925665 9135 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Drug Central 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 None
CHEMBL301523 9135 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Drug Central 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 None
DB00120 9135 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Drug Central 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 None
2780 9152 106 None 13 2 Human 8.3 pIC50 = 8.3 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Drug Central 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N None
6305 9152 106 None 13 2 Human 8.3 pIC50 = 8.3 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Drug Central 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N None
6923516 9152 106 None 13 2 Human 8.3 pIC50 = 8.3 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Drug Central 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N None
717 9152 106 None 13 2 Human 8.3 pIC50 = 8.3 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Drug Central 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N None
CHEMBL54976 9152 106 None 13 2 Human 8.3 pIC50 = 8.3 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Drug Central 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N None
DB00150 9152 106 None 13 2 Human 8.3 pIC50 = 8.3 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Drug Central 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N None
12363 9527 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Inhibition of Ca<sup>2+</sup> mobilizationInhibition of Ca<sup>2+</sup> mobilization
Guide to Pharmacology 340 1 1 3 4.8 Oc1cc2c(cc1)c(=O)c(c1ccc(Cl)cc1)c(o2)C(F)(F)F 36736525
5348723 9527 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Inhibition of Ca<sup>2+</sup> mobilizationInhibition of Ca<sup>2+</sup> mobilization
Guide to Pharmacology 340 1 1 3 4.8 Oc1cc2c(cc1)c(=O)c(c1ccc(Cl)cc1)c(o2)C(F)(F)F 36736525
2144 9135 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 26349500
3313 9135 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 26349500
6140 9135 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 26349500
6925665 9135 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 26349500
CHEMBL301523 9135 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 26349500
DB00120 9135 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 26349500
2780 9152 106 None 13 2 Human 4.6 pIC50 = 4.6 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 26349500
6305 9152 106 None 13 2 Human 4.6 pIC50 = 4.6 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 26349500
6923516 9152 106 None 13 2 Human 4.6 pIC50 = 4.6 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 26349500
717 9152 106 None 13 2 Human 4.6 pIC50 = 4.6 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 26349500
CHEMBL54976 9152 106 None 13 2 Human 4.6 pIC50 = 4.6 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 26349500
DB00150 9152 106 None 13 2 Human 4.6 pIC50 = 4.6 Functional
Measured using a GTP&gamma;S assay in transfected COS7 cells.Measured using a GTP&gamma;S assay in transfected COS7 cells.
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 26349500
789353 9133 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 329 4 1 2 4.8 Cc1ccccc1NS(=O)(=O)c1ccc(cc1)C1CCCCC1 19525486
8774 9133 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 329 4 1 2 4.8 Cc1ccccc1NS(=O)(=O)c1ccc(cc1)C1CCCCC1 19525486
5017692 9526 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 289 3 0 2 3.4 COc1ccc(cc1)C1N(c2ccccc2)C(=O)C1(F)F 26027661
8775 9526 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 289 3 0 2 3.4 COc1ccc(cc1)C1N(c2ccccc2)C(=O)C1(F)F 26027661




Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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153585580 186223 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 411 6 1 8 1.7 COc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 nan
CHEMBL4740491 186223 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 411 6 1 8 1.7 COc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 nan
148397968 186414 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 363 4 1 6 1.9 Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 nan
CHEMBL4742901 186414 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 363 4 1 6 1.9 Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 nan
153585666 186416 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 378 5 1 6 2.2 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 nan
CHEMBL4742949 186416 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 378 5 1 6 2.2 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 nan
147451915 186466 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 348 4 1 5 2.2 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4743612 186466 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 348 4 1 5 2.2 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(F)c1 nan
153585625 186472 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 324 4 1 5 2.0 Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(C)ccn3c2=O)cc1 nan
CHEMBL4743662 186472 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 324 4 1 5 2.0 Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(C)ccn3c2=O)cc1 nan
153585420 186589 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 364 4 1 5 2.7 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(Cl)c1 nan
CHEMBL4744927 186589 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 364 4 1 5 2.7 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(Cl)c1 nan
153585722 186726 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 394 5 1 6 2.6 Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 nan
CHEMBL4746401 186726 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 394 5 1 6 2.6 Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 nan
162649907 186862 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 378 5 2 7 1.6 CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 nan
CHEMBL4748076 186862 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 378 5 2 7 1.6 CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 nan
152844759 186878 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 389 5 1 6 2.4 C[C@H](NC(=O)Cn1nc2ncc(C3CC3)cn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4748306 186878 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 389 5 1 6 2.4 C[C@H](NC(=O)Cn1nc2ncc(C3CC3)cn2c1=O)c1ccc(Cl)c(F)c1 nan
153585686 187032 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 410 6 1 7 2.3 COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 nan
CHEMBL4750288 187032 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 410 6 1 7 2.3 COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 nan
147641221 187075 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 344 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1 nan
CHEMBL4750914 187075 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 344 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1 nan
153585718 187120 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 373 4 1 6 2.0 C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4751304 187120 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 373 4 1 6 2.0 C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 nan
153585581 187141 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 373 4 1 6 2.0 C[C@H](NC(=O)Cn1nc2ccc(C#N)cn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4751501 187141 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 373 4 1 6 2.0 C[C@H](NC(=O)Cn1nc2ccc(C#N)cn2c1=O)c1ccc(Cl)c(F)c1 nan
153585708 187236 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 348 4 1 5 2.2 C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(Cl)cc1 nan
CHEMBL4752808 187236 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 348 4 1 5 2.2 C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(Cl)cc1 nan
153585648 187296 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 366 4 1 5 2.3 C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4753388 187296 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 366 4 1 5 2.3 C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(Cl)c(F)c1 nan
162653764 187312 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 389 5 1 6 2.4 C[C@H](NC(=O)Cn1nc2cc(C3CC3)cnn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4753640 187312 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 389 5 1 6 2.4 C[C@H](NC(=O)Cn1nc2cc(C3CC3)cnn2c1=O)c1ccc(Cl)c(F)c1 nan
153585540 187387 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 398 5 1 6 2.4 C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4754565 187387 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 398 5 1 6 2.4 C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
153585467 187388 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 410 6 1 7 2.3 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 nan
CHEMBL4754576 187388 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 410 6 1 7 2.3 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 nan
152015494 187402 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 389 5 1 6 2.4 C[C@H](NC(=O)Cn1nc2c(C3CC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4754735 187402 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 389 5 1 6 2.4 C[C@H](NC(=O)Cn1nc2c(C3CC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 nan
150352344 187550 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 389 5 1 6 2.4 C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4756243 187550 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 389 5 1 6 2.4 C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(Cl)c(F)c1 nan
162655689 187562 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 379 5 1 7 1.6 COc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 nan
CHEMBL4756356 187562 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 379 5 1 7 1.6 COc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 nan
153585712 187570 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 419 6 2 7 2.0 C[C@H](NC(=O)Cn1nc2cc(NC3COC3)ccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4756431 187570 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 419 6 2 7 2.0 C[C@H](NC(=O)Cn1nc2cc(NC3COC3)ccn2c1=O)c1ccc(Cl)c(F)c1 nan
153585415 187667 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 363 4 1 6 2.1 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O nan
CHEMBL4757506 187667 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 363 4 1 6 2.1 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O nan
153585630 187774 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 346 4 1 5 2.0 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(F)cn3c2=O)cc1F nan
CHEMBL4758841 187774 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 346 4 1 5 2.0 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(F)cn3c2=O)cc1F nan
153585534 187863 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 413 5 1 7 2.1 Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 nan
CHEMBL4759991 187863 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 413 5 1 7 2.1 Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 nan
153585651 187981 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 382 4 1 5 2.8 C[C@H](NC(=O)Cn1nc2cc(Cl)ccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4761154 187981 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 382 4 1 5 2.8 C[C@H](NC(=O)Cn1nc2cc(Cl)ccn2c1=O)c1ccc(Cl)c(F)c1 nan
153585591 188055 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 344 4 1 5 2.3 Cc1cc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)ccc1Cl nan
CHEMBL4762126 188055 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 344 4 1 5 2.3 Cc1cc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)ccc1Cl nan
162659465 188099 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 379 5 1 7 1.6 COc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 nan
CHEMBL4762651 188099 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 379 5 1 7 1.6 COc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 nan
153585610 188224 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 344 4 1 5 2.3 Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O nan
CHEMBL4764290 188224 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 344 4 1 5 2.3 Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O nan
153585689 188285 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 340 5 1 6 1.7 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2c1 nan
CHEMBL4764967 188285 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 340 5 1 6 1.7 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2c1 nan
162661302 188296 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 383 4 1 6 2.2 C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4765018 188296 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 383 4 1 6 2.2 C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(Cl)c(F)c1 nan
153585427 188760 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 324 4 1 5 2.0 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(C)cn3c2=O)cc1 nan
CHEMBL4780358 188760 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 324 4 1 5 2.0 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(C)cn3c2=O)cc1 nan
153585638 188979 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 379 5 1 7 1.6 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 nan
CHEMBL4782901 188979 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 379 5 1 7 1.6 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 nan
153585409 189250 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 394 5 1 6 2.6 Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 nan
CHEMBL4786542 189250 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 394 5 1 6 2.6 Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 nan
147410414 189460 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 363 4 1 6 1.9 Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 nan
CHEMBL4789252 189460 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 363 4 1 6 1.9 Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 nan
153585385 189596 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 360 5 1 6 2.0 COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n12 nan
CHEMBL4790949 189596 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 360 5 1 6 2.0 COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n12 nan
162671538 189608 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 417 4 1 6 2.6 C[C@H](NC(=O)Cn1nc2c(C(F)(F)F)ccnn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4791193 189608 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 417 4 1 6 2.6 C[C@H](NC(=O)Cn1nc2c(C(F)(F)F)ccnn2c1=O)c1ccc(Cl)c(F)c1 nan
162671011 189723 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 345 4 1 6 1.7 Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 nan
CHEMBL4792732 189723 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 345 4 1 6 1.7 Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 nan
148156995 189734 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 460 8 2 8 2.3 C[C@H](NC(=O)Cn1nc2c(NCC(F)F)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4792896 189734 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 460 8 2 8 2.3 C[C@H](NC(=O)Cn1nc2c(NCC(F)F)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
151533016 189749 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 339 5 2 6 1.7 CNc1cccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc12 nan
CHEMBL4793093 189749 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 339 5 2 6 1.7 CNc1cccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc12 nan
153585429 190191 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 340 5 1 6 1.7 COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n12 nan
CHEMBL4798385 190191 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 340 5 1 6 1.7 COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n12 nan
153585699 190280 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 362 4 1 5 2.5 Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 nan
CHEMBL4799647 190280 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 362 4 1 5 2.5 Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 nan
153585528 190343 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 344 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1Cl nan
CHEMBL4800338 190343 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 344 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1Cl nan
162644596 186198 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 2.1 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O nan
CHEMBL4740228 186198 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 2.1 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O nan
153585418 186226 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 434 5 1 8 1.4 C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)cnn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4740519 186226 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 434 5 1 8 1.4 C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)cnn2c1=O)c1ccc(Cl)c(F)c1 nan
153585684 186312 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 377 4 1 6 2.2 Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 nan
CHEMBL4741467 186312 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 377 4 1 6 2.2 Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 nan
152956498 186489 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 324 4 1 5 2.2 Cc1ccc([C@H](C)NC(=O)C(C)n2nc3ccccn3c2=O)cc1 nan
CHEMBL4743938 186489 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 324 4 1 5 2.2 Cc1ccc([C@H](C)NC(=O)C(C)n2nc3ccccn3c2=O)cc1 nan
153585688 186537 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 479 6 2 8 2.2 C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4744340 186537 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 479 6 2 8 2.2 C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
162648790 186566 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 nan
CHEMBL4744737 186566 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 nan
153585420 186589 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 364 4 1 5 2.7 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(Cl)c1 nan
CHEMBL4744927 186589 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 364 4 1 5 2.7 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(Cl)c1 nan
162647825 186614 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 399 5 1 7 1.8 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 nan
CHEMBL4745096 186614 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 399 5 1 7 1.8 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 nan
152005060 186641 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 447 5 1 8 1.3 C[C@H](NC(=O)Cn1nc2c(N3CCN(C)CC3)nccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4745432 186641 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 447 5 1 8 1.3 C[C@H](NC(=O)Cn1nc2c(N3CCN(C)CC3)nccn2c1=O)c1ccc(Cl)c(F)c1 nan
150995037 186698 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 349 4 1 6 1.6 C[C@H](NC(=O)Cn1nc2cnccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4746108 186698 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 349 4 1 6 1.6 C[C@H](NC(=O)Cn1nc2cnccn2c1=O)c1ccc(Cl)c(F)c1 nan
153585512 186807 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 367 4 1 6 1.7 C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4747431 186807 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 367 4 1 6 1.7 C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)c(F)c1 nan
162650006 186904 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2cccnn2c1=O nan
CHEMBL4748681 186904 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2cccnn2c1=O nan
151976938 187019 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 310 4 1 5 1.7 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 nan
CHEMBL4750143 187019 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 310 4 1 5 1.7 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 nan
153585686 187032 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 410 6 1 7 2.3 COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 nan
CHEMBL4750288 187032 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 410 6 1 7 2.3 COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 nan
147634500 187057 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F nan
CHEMBL4750692 187057 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F nan
147641221 187075 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 344 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1 nan
CHEMBL4750914 187075 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 344 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1 nan
153585718 187120 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 373 4 1 6 2.0 C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4751304 187120 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 373 4 1 6 2.0 C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 nan
153585721 187130 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 383 4 1 6 2.2 C[C@H](NC(=O)Cn1nc2ncc(Cl)cn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4751414 187130 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 383 4 1 6 2.2 C[C@H](NC(=O)Cn1nc2ncc(Cl)cn2c1=O)c1ccc(Cl)c(F)c1 nan
153585581 187141 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 373 4 1 6 2.0 C[C@H](NC(=O)Cn1nc2ccc(C#N)cn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4751501 187141 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 373 4 1 6 2.0 C[C@H](NC(=O)Cn1nc2ccc(C#N)cn2c1=O)c1ccc(Cl)c(F)c1 nan
153585514 187152 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 311 4 1 6 1.1 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1 nan
CHEMBL4751629 187152 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 311 4 1 6 1.1 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1 nan
153585541 187160 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 341 5 1 7 1.1 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2n1 nan
CHEMBL4751720 187160 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 341 5 1 7 1.1 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2n1 nan
162653366 187239 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 410 6 2 8 1.7 CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 nan
CHEMBL4752829 187239 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 410 6 2 8 1.7 CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 nan
153585655 187255 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 493 7 1 8 2.9 COC1CCN(c2ccn3c(=O)n(CC(=O)N[C@@H](C)c4ccc(OC(F)(F)F)cc4)nc3c2)CC1 nan
CHEMBL4752993 187255 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 493 7 1 8 2.9 COC1CCN(c2ccn3c(=O)n(CC(=O)N[C@@H](C)c4ccc(OC(F)(F)F)cc4)nc3c2)CC1 nan
153585421 187300 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 447 5 1 7 2.4 CC1COCCN1c1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 nan
CHEMBL4753419 187300 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 447 5 1 7 2.4 CC1COCCN1c1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 nan
147378727 187306 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 380 6 1 6 2.1 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)c(F)c1 nan
CHEMBL4753547 187306 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 380 6 1 6 2.1 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)c(F)c1 nan
162653797 187309 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 329 4 1 6 1.2 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F nan
CHEMBL4753587 187309 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 329 4 1 6 1.2 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F nan
148512747 187336 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 395 5 1 7 2.0 Cc1nccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 nan
CHEMBL4753915 187336 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 395 5 1 7 2.0 Cc1nccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 nan
149101043 187382 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 415 5 1 7 2.3 C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4754476 187382 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 415 5 1 7 2.3 C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
153585478 187384 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 479 6 2 8 2.2 C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4754503 187384 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 479 6 2 8 2.2 C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
153585540 187387 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 398 5 1 6 2.4 C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4754565 187387 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 398 5 1 6 2.4 C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
153585445 187536 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 382 4 1 5 2.5 C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(C(F)(F)F)cc1 nan
CHEMBL4756137 187536 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 382 4 1 5 2.5 C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(C(F)(F)F)cc1 nan
94095050 187590 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 380 5 1 6 2.3 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4756787 187590 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 380 5 1 6 2.3 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
162657043 187601 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 379 5 1 7 1.6 COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2n1 nan
CHEMBL4756879 187601 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 379 5 1 7 1.6 COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2n1 nan
162656575 187662 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 355 5 1 6 1.8 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)c(F)c1 nan
CHEMBL4757480 187662 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 355 5 1 6 1.8 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)c(F)c1 nan
162656504 187675 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 420 6 2 8 1.4 C[C@H](NC(=O)Cn1nc2c(NC3COC3)nccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4757619 187675 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 420 6 2 8 1.4 C[C@H](NC(=O)Cn1nc2c(NC3COC3)nccn2c1=O)c1ccc(Cl)c(F)c1 nan
152460205 187713 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 451 6 2 8 1.5 C[C@H](NC(=O)Cn1nc2cccc(N3CC(O)C3)n2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4758096 187713 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 451 6 2 8 1.5 C[C@H](NC(=O)Cn1nc2cccc(N3CC(O)C3)n2c1=O)c1ccc(OC(F)(F)F)cc1 nan
153585448 187729 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 411 6 1 8 1.7 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2n1 nan
CHEMBL4758322 187729 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 411 6 1 8 1.7 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2n1 nan
149421402 187735 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 452 7 1 8 2.1 C[C@H](NC(=O)Cn1nc2cc(OC3COC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4758375 187735 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 452 7 1 8 2.1 C[C@H](NC(=O)Cn1nc2cc(OC3COC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
162657688 187834 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1cc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)ccc1Cl nan
CHEMBL4759611 187834 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1cc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)ccc1Cl nan
162657416 187899 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 nan
CHEMBL4760528 187899 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 nan
150924716 187945 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 340 5 1 6 1.7 COc1cccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc12 nan
CHEMBL4760914 187945 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 340 5 1 6 1.7 COc1cccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc12 nan
153585574 188000 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 2.1 C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4761321 188000 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 2.1 C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 nan
162660420 188054 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 5 1 6 2.0 CC[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4762121 188054 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 5 1 6 2.0 CC[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 nan
153585591 188055 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 344 4 1 5 2.3 Cc1cc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)ccc1Cl nan
CHEMBL4762126 188055 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 344 4 1 5 2.3 Cc1cc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)ccc1Cl nan
147987797 188063 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 364 4 1 5 2.4 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 nan
CHEMBL4762206 188063 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 364 4 1 5 2.4 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 nan
147323186 188163 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 325 4 1 6 1.4 Cc1ccc([C@H](C)NC(=O)Cn2nc3cnc(C)cn3c2=O)cc1 nan
CHEMBL4763362 188163 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 325 4 1 6 1.4 Cc1ccc([C@H](C)NC(=O)Cn2nc3cnc(C)cn3c2=O)cc1 nan
153585610 188224 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 344 4 1 5 2.3 Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O nan
CHEMBL4764290 188224 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 344 4 1 5 2.3 Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O nan
162661581 188243 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 362 4 1 5 2.7 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O nan
CHEMBL4764506 188243 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 362 4 1 5 2.7 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O nan
152494840 188276 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 479 6 2 8 2.2 C[C@H](NC(=O)Cn1nc2cc(N3CCC(O)CC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4764839 188276 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 479 6 2 8 2.2 C[C@H](NC(=O)Cn1nc2cc(N3CCC(O)CC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
162661302 188296 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 383 4 1 6 2.2 C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4765018 188296 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 383 4 1 6 2.2 C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(Cl)c(F)c1 nan
153585547 188520 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 420 6 2 8 1.4 C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4777214 188520 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 420 6 2 8 1.4 C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 nan
162644369 188609 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 343 4 1 6 1.5 Cc1ccc([C@H](C)NC(=O)Cn2nc3c(C)ccnn3c2=O)cc1F nan
CHEMBL4778327 188609 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 343 4 1 6 1.5 Cc1ccc([C@H](C)NC(=O)Cn2nc3c(C)ccnn3c2=O)cc1F nan
162665057 188845 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 365 4 1 6 2.1 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 nan
CHEMBL4781404 188845 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 365 4 1 6 2.1 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 nan
150561998 188910 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 475 4 1 6 2.2 C[C@H](NC(=O)Cn1nc2c(I)ccnn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4782195 188910 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 475 4 1 6 2.2 C[C@H](NC(=O)Cn1nc2c(I)ccnn2c1=O)c1ccc(Cl)c(F)c1 nan
149618414 189040 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 325 4 2 6 1.3 Cc1ccc([C@H](C)NC(=O)Cn2nc3c(N)cccn3c2=O)cc1 nan
CHEMBL4783739 189040 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 325 4 2 6 1.3 Cc1ccc([C@H](C)NC(=O)Cn2nc3c(N)cccn3c2=O)cc1 nan
153585463 189186 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 433 5 1 7 2.0 C[C@H](NC(=O)Cn1nc2cccc(N3CCOCC3)n2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4785639 189186 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 433 5 1 7 2.0 C[C@H](NC(=O)Cn1nc2cccc(N3CCOCC3)n2c1=O)c1ccc(Cl)c(F)c1 nan
153585417 189206 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1Cl nan
CHEMBL4785963 189206 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1Cl nan
153585609 189251 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 465 6 1 8 2.1 C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4786573 189251 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 465 6 1 8 2.1 C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
151394869 189315 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 349 4 1 6 1.6 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4787308 189315 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 349 4 1 6 1.6 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 nan
153585701 189332 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 463 6 1 7 3.3 C[C@H](NC(=O)Cn1nc2cccc(N3CCCCC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4787547 189332 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 463 6 1 7 3.3 C[C@H](NC(=O)Cn1nc2cccc(N3CCCCC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 nan
151043804 189454 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 349 4 1 6 1.6 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4789123 189454 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 349 4 1 6 1.6 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 nan
162670176 189530 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 377 5 1 6 2.2 CC(C)[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4790080 189530 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 377 5 1 6 2.2 CC(C)[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 nan
153585385 189596 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 360 5 1 6 2.0 COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n12 nan
CHEMBL4790949 189596 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 360 5 1 6 2.0 COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n12 nan
153585679 189702 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 329 4 1 6 1.2 Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F nan
CHEMBL4792515 189702 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 329 4 1 6 1.2 Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F nan
162671011 189723 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 nan
CHEMBL4792732 189723 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 nan
148156995 189734 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 460 8 2 8 2.3 C[C@H](NC(=O)Cn1nc2c(NCC(F)F)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4792896 189734 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 460 8 2 8 2.3 C[C@H](NC(=O)Cn1nc2c(NCC(F)F)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
153585524 189909 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 328 4 1 5 1.8 Cc1ccc([C@H](C)NC(=O)Cn2nc3c(F)cccn3c2=O)cc1 nan
CHEMBL4795078 189909 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 328 4 1 5 1.8 Cc1ccc([C@H](C)NC(=O)Cn2nc3c(F)cccn3c2=O)cc1 nan
153585504 189990 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 410 6 1 7 2.3 COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 nan
CHEMBL4795956 189990 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 410 6 1 7 2.3 COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 nan
153585386 190012 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 415 5 1 7 2.3 C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4796254 190012 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 415 5 1 7 2.3 C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
153585438 190139 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2c1 nan
CHEMBL4797724 190139 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2c1 nan
153585532 190171 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 328 4 1 5 1.8 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 nan
CHEMBL4798029 190171 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 328 4 1 5 1.8 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 nan
153585429 190191 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 340 5 1 6 1.7 COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n12 nan
CHEMBL4798385 190191 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 340 5 1 6 1.7 COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n12 nan
153585528 190343 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 344 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1Cl nan
CHEMBL4800338 190343 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 344 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1Cl nan
153585707 190357 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 361 5 1 7 1.4 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 nan
CHEMBL4800487 190357 0 None - 0 Rat 9.0 pEC50 = 9 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 361 5 1 7 1.4 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 nan
162644596 186198 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 363 4 1 6 2.1 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O nan
CHEMBL4740228 186198 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 363 4 1 6 2.1 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O nan
162648790 186566 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 363 4 1 6 1.9 Cc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 nan
CHEMBL4744737 186566 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 363 4 1 6 1.9 Cc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 nan
162647825 186614 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 399 5 1 7 1.8 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 nan
CHEMBL4745096 186614 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 399 5 1 7 1.8 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 nan
162649809 186824 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 458 5 1 7 2.1 C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4747632 186824 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 458 5 1 7 2.1 C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 nan
151976938 187019 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 310 4 1 5 1.7 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 nan
CHEMBL4750143 187019 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 310 4 1 5 1.7 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 nan
147634500 187057 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 363 4 1 6 1.9 Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F nan
CHEMBL4750692 187057 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 363 4 1 6 1.9 Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F nan
149094095 187061 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 421 6 1 7 2.5 C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4750718 187061 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 421 6 1 7 2.5 C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
162653366 187239 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 410 6 2 8 1.7 CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 nan
CHEMBL4752829 187239 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 410 6 2 8 1.7 CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 nan
162653797 187309 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 329 4 1 6 1.2 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F nan
CHEMBL4753587 187309 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 329 4 1 6 1.2 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F nan
152007746 187345 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 368 5 1 6 2.3 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3c(C)cc(C)cc3C)nc2c1 nan
CHEMBL4754043 187345 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 368 5 1 6 2.3 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3c(C)cc(C)cc3C)nc2c1 nan
153585713 187750 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 328 4 1 5 1.8 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(F)cn3c2=O)cc1 nan
CHEMBL4758561 187750 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 328 4 1 5 1.8 Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(F)cn3c2=O)cc1 nan
153585574 188000 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 363 4 1 6 2.1 C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4761321 188000 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 363 4 1 6 2.1 C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 nan
147987797 188063 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 364 4 1 5 2.4 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 nan
CHEMBL4762206 188063 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 364 4 1 5 2.4 C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 nan
162661581 188243 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 362 4 1 5 2.7 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O nan
CHEMBL4764506 188243 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 362 4 1 5 2.7 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O nan
153585547 188520 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 420 6 2 8 1.4 C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4777214 188520 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 420 6 2 8 1.4 C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 nan
162644369 188609 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 343 4 1 6 1.5 Cc1ccc([C@H](C)NC(=O)Cn2nc3c(C)ccnn3c2=O)cc1F nan
CHEMBL4778327 188609 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 343 4 1 6 1.5 Cc1ccc([C@H](C)NC(=O)Cn2nc3c(C)ccnn3c2=O)cc1F nan
162665057 188845 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 365 4 1 6 2.1 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 nan
CHEMBL4781404 188845 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 365 4 1 6 2.1 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 nan
151043804 189454 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 349 4 1 6 1.6 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4789123 189454 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 349 4 1 6 1.6 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 nan
153585679 189702 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 329 4 1 6 1.2 Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F nan
CHEMBL4792515 189702 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 329 4 1 6 1.2 Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F nan
162670606 189717 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 363 4 1 6 1.9 Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2n1 nan
CHEMBL4792682 189717 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 363 4 1 6 1.9 Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2n1 nan
153585386 190012 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 415 5 1 7 2.3 C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4796254 190012 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 415 5 1 7 2.3 C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
153585532 190171 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 328 4 1 5 1.8 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 nan
CHEMBL4798029 190171 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 328 4 1 5 1.8 Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 nan
147477854 190277 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 433 5 1 7 2.0 C[C@H](NC(=O)Cn1nc2c(N3CCOCC3)cccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4799618 190277 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
ChEMBL 433 5 1 7 2.0 C[C@H](NC(=O)Cn1nc2c(N3CCOCC3)cccn2c1=O)c1ccc(Cl)c(F)c1 nan
162644596 186198 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 2.1 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O nan
CHEMBL4740228 186198 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 2.1 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O nan
162648528 186593 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 337 5 1 6 1.6 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)cc1 nan
CHEMBL4744984 186593 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 337 5 1 6 1.6 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)cc1 nan
146976458 186809 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 507 5 1 7 2.3 C[C@H](NC(=O)Cn1nc2c(I)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4747440 186809 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 507 5 1 7 2.3 C[C@H](NC(=O)Cn1nc2c(I)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
162649809 186824 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 458 5 1 7 2.1 C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4747632 186824 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 458 5 1 7 2.1 C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 nan
152844759 186878 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 389 5 1 6 2.4 C[C@H](NC(=O)Cn1nc2ncc(C3CC3)cn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4748306 186878 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 389 5 1 6 2.4 C[C@H](NC(=O)Cn1nc2ncc(C3CC3)cn2c1=O)c1ccc(Cl)c(F)c1 nan
153585550 187172 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 355 5 1 6 1.8 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(C2CC2)c(F)c1 nan
CHEMBL4751886 187172 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 355 5 1 6 1.8 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(C2CC2)c(F)c1 nan
152007746 187345 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 368 5 1 6 2.3 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3c(C)cc(C)cc3C)nc2c1 nan
CHEMBL4754043 187345 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 368 5 1 6 2.3 COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3c(C)cc(C)cc3C)nc2c1 nan
153585588 187565 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 444 5 2 7 1.7 C[C@H](NC(=O)Cn1nc2c(N3CCC34CNC4)cccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4756392 187565 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 444 5 2 7 1.7 C[C@H](NC(=O)Cn1nc2c(N3CCC34CNC4)cccn2c1=O)c1ccc(Cl)c(F)c1 nan
153585575 187608 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 433 5 2 8 1.0 C[C@H](NC(=O)Cn1nc2c(N3CCNCC3)nccn2c1=O)c1ccc(Cl)c(F)c1 nan
CHEMBL4756937 187608 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 433 5 2 8 1.0 C[C@H](NC(=O)Cn1nc2c(N3CCNCC3)nccn2c1=O)c1ccc(Cl)c(F)c1 nan
153585415 187667 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 2.1 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O nan
CHEMBL4757506 187667 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 2.1 CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O nan
153585534 187863 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 413 5 1 7 2.1 Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 nan
CHEMBL4759991 187863 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 413 5 1 7 2.1 Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 nan
153585663 187934 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1Cl nan
CHEMBL4760812 187934 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 345 4 1 6 1.7 Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1Cl nan
153585643 188120 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 381 5 1 7 1.7 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4762957 188120 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 381 5 1 7 1.7 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)cc1 nan
134043805 188548 1 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 362 6 1 6 2.0 CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 nan
CHEMBL4777673 188548 1 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 362 6 1 6 2.0 CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 nan
153585542 189085 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 365 4 1 6 2.1 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(Cl)c1 nan
CHEMBL4784153 189085 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 365 4 1 6 2.1 C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(Cl)c1 nan
162667558 189241 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 331 4 1 6 1.4 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)cc1 nan
CHEMBL4786371 189241 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 331 4 1 6 1.4 C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)cc1 nan
147410414 189460 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 nan
CHEMBL4789252 189460 0 None - 0 Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at rat GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay
ChEMBL 363 4 1 6 1.9 Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 nan
121349671 188532 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 350 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 nan
CHEMBL4777495 188532 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 350 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 nan
121349806 190153 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 394 4 1 5 2.8 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(C(F)(F)F)cc1 nan
CHEMBL4797857 190153 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 394 4 1 5 2.8 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(C(F)(F)F)cc1 nan
121349656 190268 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 424 5 1 6 2.8 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3F)c(=O)c12 nan
CHEMBL4799483 190268 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 424 5 1 6 2.8 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3F)c(=O)c12 nan
121349756 189346 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 356 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 nan
CHEMBL4787761 189346 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 356 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 nan
27785340 190250 1 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 322 4 1 5 2.0 Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O 10.1021/acs.jmedchem.1c00820
CHEMBL4799237 190250 1 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 322 4 1 5 2.0 Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O 10.1021/acs.jmedchem.1c00820
27785340 190250 1 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 322 4 1 5 2.0 Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O nan
CHEMBL4799237 190250 1 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 322 4 1 5 2.0 Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O nan
121349782 189823 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 406 5 1 6 2.7 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c2c1 nan
CHEMBL4794046 189823 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 406 5 1 6 2.7 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c2c1 nan
164619649 192545 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 342 5 1 5 1.8 O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1Cl 10.1021/acs.jmedchem.1c00820
CHEMBL4866435 192545 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 342 5 1 5 1.8 O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1Cl 10.1021/acs.jmedchem.1c00820
26810968 193062 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 358 4 1 5 2.8 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1cccc2ccccc12 10.1021/acs.jmedchem.1c00820
CHEMBL4874147 193062 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 358 4 1 5 2.8 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1cccc2ccccc12 10.1021/acs.jmedchem.1c00820
11685 10911 25 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 10.1021/acs.jmedchem.1c00820
121349608 10911 25 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 10.1021/acs.jmedchem.1c00820
CHEMBL4779773 10911 25 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 10.1021/acs.jmedchem.1c00820
11685 10911 25 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 nan
121349608 10911 25 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 nan
CHEMBL4779773 10911 25 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 nan
121349786 189032 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 404 7 1 7 2.3 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 10.1021/acs.jmedchem.1c00820
CHEMBL4783626 189032 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 404 7 1 7 2.3 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 10.1021/acs.jmedchem.1c00820
121349639 189196 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 410 5 1 6 2.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F 10.1021/acs.jmedchem.1c00820
CHEMBL4785741 189196 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 410 5 1 6 2.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F 10.1021/acs.jmedchem.1c00820
121349786 189032 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 404 7 1 7 2.3 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 nan
CHEMBL4783626 189032 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 404 7 1 7 2.3 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 nan
121349639 189196 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 410 5 1 6 2.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F nan
CHEMBL4785741 189196 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 410 5 1 6 2.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F nan
2695546 192895 12 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 342 5 1 5 1.8 O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(Cl)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4871792 192895 12 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 342 5 1 5 1.8 O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(Cl)cc1 10.1021/acs.jmedchem.1c00820
121349600 189364 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 422 6 1 7 2.6 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c2c1 nan
CHEMBL4788013 189364 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 422 6 1 7 2.6 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c2c1 nan
121349548 190208 1 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 338 5 1 6 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4798667 190208 1 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 338 5 1 6 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349548 190208 1 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 338 5 1 6 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 nan
CHEMBL4798667 190208 1 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 338 5 1 6 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 nan
121349554 190318 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(OC)ccc3c2=O)cc1 nan
CHEMBL4800089 190318 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(OC)ccc3c2=O)cc1 nan
36428174 188721 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 376 4 1 5 2.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4779855 188721 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 376 4 1 5 2.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.1c00820
36428174 188721 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 376 4 1 5 2.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 nan
CHEMBL4779855 188721 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 376 4 1 5 2.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 nan
121349659 189044 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 nan
CHEMBL4783774 189044 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 nan
121349593 189652 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 394 4 1 5 2.8 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F 10.1021/acs.jmedchem.1c00820
CHEMBL4791792 189652 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 394 4 1 5 2.8 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F 10.1021/acs.jmedchem.1c00820
121349593 189652 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 394 4 1 5 2.8 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F nan
CHEMBL4791792 189652 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 394 4 1 5 2.8 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F nan
121349633 189496 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O 10.1021/acs.jmedchem.1c00820
CHEMBL4789631 189496 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O 10.1021/acs.jmedchem.1c00820
121349633 189496 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O nan
CHEMBL4789631 189496 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O nan
2714527 192184 2 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 308 4 1 5 1.7 C[C@@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 10.1021/acs.jmedchem.1c00820
CHEMBL4861019 192184 2 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 308 4 1 5 1.7 C[C@@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 10.1021/acs.jmedchem.1c00820
2714528 189257 2 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 308 4 1 5 1.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 nan
CHEMBL4786641 189257 2 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 308 4 1 5 1.7 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 nan
27838947 192210 2 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 342 5 1 5 1.8 O=C(Cn1nnc2ccccc2c1=O)NCCc1cccc(Cl)c1 10.1021/acs.jmedchem.1c00820
CHEMBL4861445 192210 2 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 342 5 1 5 1.8 O=C(Cn1nnc2ccccc2c1=O)NCCc1cccc(Cl)c1 10.1021/acs.jmedchem.1c00820
121349658 189482 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 10.1021/acs.jmedchem.1c00820
CHEMBL4789475 189482 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 10.1021/acs.jmedchem.1c00820
121349658 189482 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 nan
CHEMBL4789475 189482 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 nan
121349597 188590 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 356 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(Cl)ccc3c2=O)cc1 nan
CHEMBL4778124 188590 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 356 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(Cl)ccc3c2=O)cc1 nan
121349631 189261 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4786722 189261 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349631 189261 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 nan
CHEMBL4786722 189261 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 nan
121349615 189904 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 366 5 1 6 2.3 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 nan
CHEMBL4795005 189904 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 366 5 1 6 2.3 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 nan
121349564 188543 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4777630 188543 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349564 188543 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 nan
CHEMBL4777630 188543 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 nan
121349588 189015 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 406 6 1 6 3.0 CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4783365 189015 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 406 6 1 6 3.0 CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1 nan
121349572 188625 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 356 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4778561 188625 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 356 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349572 188625 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 356 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 nan
CHEMBL4778561 188625 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 356 4 1 5 2.6 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 nan
121349778 189135 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 406 5 1 6 3.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 nan
CHEMBL4784744 189135 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 406 5 1 6 3.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 nan
164617980 191808 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 377 4 1 6 2.1 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)nc1 10.1021/acs.jmedchem.1c00820
CHEMBL4855076 191808 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 377 4 1 6 2.1 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)nc1 10.1021/acs.jmedchem.1c00820
121349738 188876 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 390 5 1 5 3.1 CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 nan
CHEMBL4781754 188876 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 390 5 1 5 3.1 CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 nan
121349559 188615 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 422 6 1 7 2.6 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc2c1 nan
CHEMBL4778354 188615 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 422 6 1 7 2.6 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc2c1 nan
164628435 193069 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 322 4 1 5 2.0 Cc1cccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c1 10.1021/acs.jmedchem.1c00820
CHEMBL4874254 193069 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 322 4 1 5 2.0 Cc1cccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c1 10.1021/acs.jmedchem.1c00820
8036946 190218 2 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 342 4 1 5 2.3 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4798779 190218 2 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 342 4 1 5 2.3 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 10.1021/acs.jmedchem.1c00820
8036946 190218 2 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 342 4 1 5 2.3 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 nan
CHEMBL4798779 190218 2 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 342 4 1 5 2.3 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 nan
121349701 188723 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 422 6 1 7 2.6 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc12 nan
CHEMBL4779884 188723 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 422 6 1 7 2.6 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc12 nan
121349710 189727 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 406 5 1 6 2.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 nan
CHEMBL4792828 189727 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 406 5 1 6 2.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 nan
121349675 188744 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 390 4 1 5 3.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 nan
CHEMBL4780038 188744 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 390 4 1 5 3.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 nan
121349683 189502 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 406 5 1 6 2.7 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c12 nan
CHEMBL4789720 189502 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 406 5 1 6 2.7 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c12 nan
121349753 189673 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 10.1021/acs.jmedchem.1c00820
CHEMBL4792136 189673 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 10.1021/acs.jmedchem.1c00820
121349753 189673 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 nan
CHEMBL4792136 189673 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 nan
78596259 192154 1 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 342 4 1 5 2.3 CC(NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4860510 192154 1 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 342 4 1 5 2.3 CC(NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 10.1021/acs.jmedchem.1c00820
121349739 188949 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 392 6 1 6 2.4 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)F)cc1 nan
CHEMBL4782619 188949 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 392 6 1 6 2.4 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)F)cc1 nan
2496250 35725 7 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 338 6 1 6 1.2 COc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL1380104 35725 7 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 338 6 1 6 1.2 COc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349685 188912 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 440 6 1 7 2.7 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 10.1021/acs.jmedchem.1c00820
CHEMBL4782204 188912 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 440 6 1 7 2.7 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 10.1021/acs.jmedchem.1c00820
121349685 188912 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 440 6 1 7 2.7 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 nan
CHEMBL4782204 188912 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 440 6 1 7 2.7 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 nan
121349719 190038 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 422 6 1 7 2.6 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 nan
CHEMBL4796493 190038 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 422 6 1 7 2.6 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 nan
121349787 189451 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 nan
CHEMBL4789079 189451 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 nan
121349623 188879 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 406 5 1 6 2.7 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc12 nan
CHEMBL4781805 188879 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 406 5 1 6 2.7 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc12 nan
121349755 188582 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 356 5 1 6 1.8 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 nan
CHEMBL4778062 188582 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 356 5 1 6 1.8 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 nan
121349773 189207 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 406 5 1 6 2.7 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc2c1 nan
CHEMBL4785980 189207 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 406 5 1 6 2.7 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc2c1 nan
121349614 188444 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 354 4 1 5 2.4 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(C)c1 nan
CHEMBL4776329 188444 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 354 4 1 5 2.4 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(C)c1 nan
121349720 189022 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(OC)cccc3c2=O)cc1 nan
CHEMBL4783544 189022 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(OC)cccc3c2=O)cc1 nan
121349645 188497 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 410 5 1 6 2.7 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL4776988 188497 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 410 5 1 6 2.7 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1 nan
164611430 192003 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 377 4 1 6 2.1 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cn1 10.1021/acs.jmedchem.1c00820
CHEMBL4857947 192003 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 377 4 1 6 2.1 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cn1 10.1021/acs.jmedchem.1c00820
121349746 190163 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 390 4 1 5 3.0 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4797979 190163 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 390 4 1 5 3.0 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349746 190163 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 390 4 1 5 3.0 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 nan
CHEMBL4797979 190163 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 390 4 1 5 3.0 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 nan
121349745 188991 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 10.1021/acs.jmedchem.1c00820
CHEMBL4783071 188991 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 10.1021/acs.jmedchem.1c00820
121349745 188991 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 nan
CHEMBL4783071 188991 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 nan
8036887 191519 1 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 322 5 1 5 1.7 C[C@@H](CNC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 10.1021/acs.jmedchem.1c00820
CHEMBL4850747 191519 1 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 322 5 1 5 1.7 C[C@@H](CNC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 10.1021/acs.jmedchem.1c00820
121349781 188627 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 nan
CHEMBL4778563 188627 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 nan
121349596 190220 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 322 4 1 5 2.0 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4798863 190220 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 322 4 1 5 2.0 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349596 190220 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 322 4 1 5 2.0 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 nan
CHEMBL4798863 190220 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 322 4 1 5 2.0 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 nan
121349728 188595 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 10.1021/acs.jmedchem.1c00820
CHEMBL4778172 188595 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 10.1021/acs.jmedchem.1c00820
121349728 188595 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 nan
CHEMBL4778172 188595 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 nan
121349688 189677 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 356 5 1 6 1.8 COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 nan
CHEMBL4792174 189677 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 356 5 1 6 1.8 COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 nan
27783537 188462 1 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 386 4 1 5 2.4 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4776509 188462 1 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 386 4 1 5 2.4 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 10.1021/acs.jmedchem.1c00820
121349587 189191 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 nan
CHEMBL4785669 189191 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 nan
121349769 189706 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 nan
CHEMBL4792561 189706 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 nan
121349689 189998 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 372 5 1 6 2.3 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 nan
CHEMBL4796061 189998 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 372 5 1 6 2.3 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 nan
121349780 193148 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 322 5 1 5 1.5 Cc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4875522 193148 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 322 5 1 5 1.5 Cc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349628 188804 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 10.1021/acs.jmedchem.1c00820
CHEMBL4780801 188804 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 10.1021/acs.jmedchem.1c00820
121349628 188804 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 nan
CHEMBL4780801 188804 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 nan
121349805 189899 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(OC)c3c2=O)cc1 nan
CHEMBL4794908 189899 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 368 6 1 7 1.7 COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(OC)c3c2=O)cc1 nan
27754276 192710 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 5 1 5 2.4 CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4869182 192710 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 5 1 5 2.4 CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C)cc1 10.1021/acs.jmedchem.1c00820
121349734 188875 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 10.1021/acs.jmedchem.1c00820
CHEMBL4781729 188875 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 10.1021/acs.jmedchem.1c00820
121349734 188875 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 nan
CHEMBL4781729 188875 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 nan
121349574 189598 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 374 6 1 6 2.3 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4790968 189598 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 374 6 1 6 2.3 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 10.1021/acs.jmedchem.1c00820
121349574 189598 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 374 6 1 6 2.3 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 nan
CHEMBL4790968 189598 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 374 6 1 6 2.3 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 nan
121349569 188694 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 nan
CHEMBL4779481 188694 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 340 4 1 5 2.1 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 nan
164609046 191264 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 4 1 5 2.5 Cc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4847108 191264 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 4 1 5 2.5 Cc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349561 189509 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 nan
CHEMBL4789791 189509 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 nan
121349719 190038 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 422 6 1 7 2.6 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 10.1021/acs.jmedchem.1c00820
CHEMBL4796493 190038 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 422 6 1 7 2.6 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 10.1021/acs.jmedchem.1c00820
121349711 189646 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 358 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(F)c1 nan
CHEMBL4791752 189646 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 358 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(F)c1 nan
121349694 188994 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 10.1021/acs.jmedchem.1c00820
CHEMBL4783106 188994 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 10.1021/acs.jmedchem.1c00820
121349694 188994 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 nan
CHEMBL4783106 188994 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 nan
121349679 193047 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 6 1 6 1.5 COc1ccc(C[C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4873905 193047 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 6 1 6 1.5 COc1ccc(C[C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349566 189431 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 372 5 1 6 2.3 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 nan
CHEMBL4788831 189431 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 372 5 1 6 2.3 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 nan
164621186 192873 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 323 4 0 6 2.4 Cc1ccc([C@H](C)OC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4871591 192873 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 323 4 0 6 2.4 Cc1ccc([C@H](C)OC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349767 190109 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 354 4 1 5 2.4 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4797410 190109 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 354 4 1 5 2.4 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349767 190109 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 354 4 1 5 2.4 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 nan
CHEMBL4797410 190109 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 354 4 1 5 2.4 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 nan
164620725 192864 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.2 COc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4871506 192864 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.2 COc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
121349809 189940 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 356 5 1 6 1.8 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 nan
CHEMBL4795372 189940 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 356 5 1 6 1.8 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 nan
121349740 188870 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 nan
CHEMBL4781651 188870 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 5 1 6 2.0 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 nan
121349795 190228 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 nan
CHEMBL4798933 190228 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 336 4 1 5 2.3 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 nan
121349558 188751 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 428 5 1 6 2.8 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1F nan
CHEMBL4780121 188751 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 428 5 1 6 2.8 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1F nan
41757362 188992 1 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 6 1 6 2.1 CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
CHEMBL4783081 188992 1 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 6 1 6 2.1 CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 10.1021/acs.jmedchem.1c00820
41757362 188992 1 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 6 1 6 2.1 CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 nan
CHEMBL4783081 188992 1 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assayDisplacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide, from human GPR139 expressed in CHO-TRex membranes incubated for 20 mins by scintillation counting assay
ChEMBL 352 6 1 6 2.1 CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 nan
2144 9135 0 None - 1 Human 3.1 pKi = 3.1 Binding
Inhibition equilibrium constant from a radioligand membrane binding assay.Inhibition equilibrium constant from a radioligand membrane binding assay.
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 26349500
3313 9135 0 None - 1 Human 3.1 pKi = 3.1 Binding
Inhibition equilibrium constant from a radioligand membrane binding assay.Inhibition equilibrium constant from a radioligand membrane binding assay.
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 26349500
6140 9135 0 None - 1 Human 3.1 pKi = 3.1 Binding
Inhibition equilibrium constant from a radioligand membrane binding assay.Inhibition equilibrium constant from a radioligand membrane binding assay.
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 26349500
6925665 9135 0 None - 1 Human 3.1 pKi = 3.1 Binding
Inhibition equilibrium constant from a radioligand membrane binding assay.Inhibition equilibrium constant from a radioligand membrane binding assay.
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 26349500
CHEMBL301523 9135 0 None - 1 Human 3.1 pKi = 3.1 Binding
Inhibition equilibrium constant from a radioligand membrane binding assay.Inhibition equilibrium constant from a radioligand membrane binding assay.
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 26349500
DB00120 9135 0 None - 1 Human 3.1 pKi = 3.1 Binding
Inhibition equilibrium constant from a radioligand membrane binding assay.Inhibition equilibrium constant from a radioligand membrane binding assay.
Guide to Pharmacology 165 3 2 2 0.6 N[C@H](C(=O)O)Cc1ccccc1 26349500
2780 9152 106 None -630 2 Human 3.1 pKi = 3.1 Binding
Inhibition equilibrium constant from a radioligand membrane binding assay.Inhibition equilibrium constant from a radioligand membrane binding assay.
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 26349500
6305 9152 106 None -630 2 Human 3.1 pKi = 3.1 Binding
Inhibition equilibrium constant from a radioligand membrane binding assay.Inhibition equilibrium constant from a radioligand membrane binding assay.
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 26349500
6923516 9152 106 None -630 2 Human 3.1 pKi = 3.1 Binding
Inhibition equilibrium constant from a radioligand membrane binding assay.Inhibition equilibrium constant from a radioligand membrane binding assay.
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 26349500
717 9152 106 None -630 2 Human 3.1 pKi = 3.1 Binding
Inhibition equilibrium constant from a radioligand membrane binding assay.Inhibition equilibrium constant from a radioligand membrane binding assay.
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 26349500
CHEMBL54976 9152 106 None -630 2 Human 3.1 pKi = 3.1 Binding
Inhibition equilibrium constant from a radioligand membrane binding assay.Inhibition equilibrium constant from a radioligand membrane binding assay.
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 26349500
DB00150 9152 106 None -630 2 Human 3.1 pKi = 3.1 Binding
Inhibition equilibrium constant from a radioligand membrane binding assay.Inhibition equilibrium constant from a radioligand membrane binding assay.
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N 26349500
11685 10911 25 None - 1 Human 6.9 pKi = 6.9 Binding
Radioligand competition binding assay using membranes isolated from CHO-T-REx cells that stably express the hGPR139Radioligand competition binding assay using membranes isolated from CHO-T-REx cells that stably express the hGPR139
Guide to Pharmacology 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 34260228
121349608 10911 25 None - 1 Human 6.9 pKi = 6.9 Binding
Radioligand competition binding assay using membranes isolated from CHO-T-REx cells that stably express the hGPR139Radioligand competition binding assay using membranes isolated from CHO-T-REx cells that stably express the hGPR139
Guide to Pharmacology 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 34260228
CHEMBL4779773 10911 25 None - 1 Human 6.9 pKi = 6.9 Binding
Radioligand competition binding assay using membranes isolated from CHO-T-REx cells that stably express the hGPR139Radioligand competition binding assay using membranes isolated from CHO-T-REx cells that stably express the hGPR139
Guide to Pharmacology 392 5 1 6 2.6 O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 34260228
2548547 8930 45 None - 1 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 316 5 2 2 2.9 O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl 26349500
8766 8930 45 None - 1 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 316 5 2 2 2.9 O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl 26349500
CHEMBL3633720 8930 45 None - 1 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 316 5 2 2 2.9 O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl 26349500