Ligand source activities (1 row/activity)





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DOI

146293963 188237 0 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 412 4 1 6 3.9 Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3)c2)nn1 nan
CHEMBL4764444 188237 0 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 412 4 1 6 3.9 Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3)c2)nn1 nan
67391041 98501 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 479 10 2 9 3.3 CCCCc1c(C(=O)NCc2cncn2CC(=O)O)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409014 98501 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 479 10 2 9 3.3 CCCCc1c(C(=O)NCc2cncn2CC(=O)O)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
146294019 187144 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 378 4 1 6 3.6 Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(Cl)c3)c2)nn1 nan
CHEMBL4751520 187144 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 378 4 1 6 3.6 Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(Cl)c3)c2)nn1 nan
146293968 187519 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 442 5 1 7 4.1 Cc1ccc(C(=O)Nc2cccc(OC(F)(F)F)c2)cc1-n1cc(-c2cncn2C)nn1 nan
CHEMBL4755970 187519 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 442 5 1 7 4.1 Cc1ccc(C(=O)Nc2cccc(OC(F)(F)F)c2)cc1-n1cc(-c2cncn2C)nn1 nan
146293961 187176 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 358 4 1 6 3.2 Cc1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 nan
CHEMBL4751970 187176 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 358 4 1 6 3.2 Cc1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 nan
146293967 188279 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 392 4 1 6 3.9 Cc1ccc(C(=O)Nc2cccc(Cl)c2)cc1-n1cc(-c2cncn2C)nn1 nan
CHEMBL4764882 188279 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 392 4 1 6 3.9 Cc1ccc(C(=O)Nc2cccc(Cl)c2)cc1-n1cc(-c2cncn2C)nn1 nan
146294023 186311 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 426 4 1 6 4.2 Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-n1cc(-c2cncn2C)nn1 nan
CHEMBL4741429 186311 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 426 4 1 6 4.2 Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-n1cc(-c2cncn2C)nn1 nan
146293970 186766 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 430 4 1 6 4.1 Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3F)c2)nn1 nan
CHEMBL4746958 186766 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 430 4 1 6 4.1 Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3F)c2)nn1 nan
146294020 189534 0 None - 1 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 428 5 1 7 3.8 Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)F)c3)c2)nn1 nan
CHEMBL4790120 189534 0 None - 1 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 428 5 1 7 3.8 Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)F)c3)c2)nn1 nan
146293969 187930 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 426 4 1 6 4.2 Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3)c2)nn1 nan
CHEMBL4760780 187930 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 426 4 1 6 4.2 Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3)c2)nn1 nan
146294026 186316 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 460 7 1 7 4.2 Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)C(F)F)c3)c2)nn1 nan
CHEMBL4741522 186316 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 460 7 1 7 4.2 Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)C(F)F)c3)c2)nn1 nan
146294021 189170 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 442 5 1 7 4.1 Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)F)c3)c2)nn1 nan
CHEMBL4785317 189170 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 442 5 1 7 4.1 Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)F)c3)c2)nn1 nan
146293959 186523 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 402 5 1 8 2.7 COC(=O)c1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 nan
CHEMBL4744201 186523 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 402 5 1 8 2.7 COC(=O)c1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 nan
153044177 190255 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 369 4 1 7 2.8 Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C#N)c3)c2)nn1 nan
CHEMBL4799308 190255 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 369 4 1 7 2.8 Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C#N)c3)c2)nn1 nan
153387722 190121 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 387 5 1 7 3.0 CN(C)c1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 nan
CHEMBL4797569 190121 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 387 5 1 7 3.0 CN(C)c1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 nan
161475867 189645 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 374 5 1 7 2.9 COc1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 nan
CHEMBL4791730 189645 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 374 5 1 7 2.9 COc1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 nan
146294022 188211 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 392 4 1 6 3.9 Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(Cl)c3)c2)nn1 nan
CHEMBL4764060 188211 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay
ChEMBL 392 4 1 6 3.9 Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(Cl)c3)c2)nn1 nan
72165163 98496 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 435 8 1 8 3.7 CCCCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409009 98496 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 435 8 1 8 3.7 CCCCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
72165165 98498 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 449 8 1 8 4.0 CCCCc1c(C(=O)NCc2c(C)ncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409011 98498 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 449 8 1 8 4.0 CCCCc1c(C(=O)NCc2c(C)ncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
67390737 98504 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 437 8 1 9 2.9 CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409019 98504 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 437 8 1 9 2.9 CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
46853632 88703 0 None 29 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse GPR142 expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at mouse GPR142 expressed in HEK293 cells by inositol phosphate accumulation assay
ChEMBL 451 8 3 5 3.7 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC1(c2ccccn2)CC1 10.1016/j.bmcl.2012.08.015
CHEMBL2164850 88703 0 None 29 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse GPR142 expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at mouse GPR142 expressed in HEK293 cells by inositol phosphate accumulation assay
ChEMBL 451 8 3 5 3.7 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC1(c2ccccn2)CC1 10.1016/j.bmcl.2012.08.015
60207828 98500 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 475 7 1 8 4.6 CCCCc1c(C(=O)NC2CCCc3ncn(C)c32)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409013 98500 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 475 7 1 8 4.6 CCCCc1c(C(=O)NC2CCCc3ncn(C)c32)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
70697110 83638 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 444 9 2 6 4.6 COc1ccc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069576 83638 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 444 9 2 6 4.6 COc1ccc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
72163408 98511 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 404 6 1 7 3.6 CCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409025 98511 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 404 6 1 7 3.6 CCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
72163554 98514 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 446 9 1 7 4.8 CCCCCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409028 98514 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 446 9 1 7 4.8 CCCCCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
135219010 183836 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 476 4 1 7 3.2 CN(C(=O)c1cccc(C(F)(F)F)c1)[C@@H]1CCO[C@H](c2nnc(-c3cnc4n3CCOC4)[nH]2)C1 10.1016/j.bmcl.2019.126857
CHEMBL4632719 183836 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 476 4 1 7 3.2 CN(C(=O)c1cccc(C(F)(F)F)c1)[C@@H]1CCO[C@H](c2nnc(-c3cnc4n3CCOC4)[nH]2)C1 10.1016/j.bmcl.2019.126857
118319570 184101 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 438 6 1 4 4.4 Cc1ncn(CC(F)F)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(Cl)c2)C1 10.1016/j.bmcl.2019.126857
CHEMBL4637087 184101 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 438 6 1 4 4.4 Cc1ncn(CC(F)F)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(Cl)c2)C1 10.1016/j.bmcl.2019.126857
72945362 99153 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 421 8 2 7 4.0 O=C(Nc1ncc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2431058 99153 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 421 8 2 7 4.0 O=C(Nc1ncc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
71451566 88697 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 446 9 3 5 3.4 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCCC1CCOCC1 10.1016/j.bmcl.2012.08.015
CHEMBL2164844 88697 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 446 9 3 5 3.4 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCCC1CCOCC1 10.1016/j.bmcl.2012.08.015
72945363 99154 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 421 8 2 7 4.0 O=C(Nc1nc(-c2ccncc2)cs1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2431059 99154 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 421 8 2 7 4.0 O=C(Nc1nc(-c2ccncc2)cs1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
141753906 184866 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 446 4 1 5 4.3 Cc1ncn(C)c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)C2)[nH]1 10.1016/j.bmcl.2019.126857
CHEMBL4647745 184866 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 446 4 1 5 4.3 Cc1ncn(C)c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)C2)[nH]1 10.1016/j.bmcl.2019.126857
71458766 88690 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 414 8 4 5 2.5 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1c[nH]cn1 10.1016/j.bmcl.2012.08.015
CHEMBL2164837 88690 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 414 8 4 5 2.5 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1c[nH]cn1 10.1016/j.bmcl.2012.08.015
69643233 83641 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 458 9 3 6 4.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2012.07.063
CHEMBL2069579 83641 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 458 9 3 6 4.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2012.07.063
156017251 184413 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 506 6 1 5 4.9 Cc1ncn(CC(F)(F)F)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(OC(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
CHEMBL4641254 184413 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 506 6 1 5 4.9 Cc1ncn(CC(F)(F)F)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(OC(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
72945363 99154 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 421 8 2 7 4.0 O=C(Nc1nc(-c2ccncc2)cs1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2431059 99154 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 421 8 2 7 4.0 O=C(Nc1nc(-c2ccncc2)cs1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
72163555 98515 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 432 7 1 7 4.5 CCC(C)c1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409029 98515 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 432 7 1 7 4.5 CCC(C)c1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
72945365 99156 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 464 9 3 7 4.3 O=C(O)c1cc(-c2ccncc2)sc1NC(=O)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2431061 99156 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 464 9 3 7 4.3 O=C(O)c1cc(-c2ccncc2)sc1NC(=O)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
72945365 99156 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 464 9 3 7 4.3 O=C(O)c1cc(-c2ccncc2)sc1NC(=O)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2431061 99156 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 464 9 3 7 4.3 O=C(O)c1cc(-c2ccncc2)sc1NC(=O)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
70693004 83611 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 334 5 3 4 1.9 N[C@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O 10.1016/j.bmcl.2012.07.063
CHEMBL2069483 83611 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 334 5 3 4 1.9 N[C@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O 10.1016/j.bmcl.2012.07.063
118319577 184911 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 450 5 1 4 5.1 Cc1ncn(C(C)C)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
CHEMBL4648456 184911 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 450 5 1 4 5.1 Cc1ncn(C(C)C)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
71449754 88694 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 439 9 3 5 3.2 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCCc1ccccn1 10.1016/j.bmcl.2012.08.015
CHEMBL2164841 88694 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 439 9 3 5 3.2 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCCc1ccccn1 10.1016/j.bmcl.2012.08.015
135218928 184756 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 488 6 1 6 4.4 Cc1ncn(CC2CC2)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)CCO2)[nH]1 10.1016/j.bmcl.2019.126857
CHEMBL4646017 184756 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 488 6 1 6 4.4 Cc1ncn(CC2CC2)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)CCO2)[nH]1 10.1016/j.bmcl.2019.126857
134194659 184852 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 412 4 1 5 4.0 Cc1ncn(C)c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(Cl)c3)C2)[nH]1 10.1016/j.bmcl.2019.126857
CHEMBL4647456 184852 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 412 4 1 5 4.0 Cc1ncn(C)c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(Cl)c3)C2)[nH]1 10.1016/j.bmcl.2019.126857
67389603 98509 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 424 8 1 9 1.8 CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(N2CCCC2)n1 10.1021/ml400186z
CHEMBL2409023 98509 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 424 8 1 9 1.8 CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(N2CCCC2)n1 10.1021/ml400186z
134194659 184852 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 412 4 1 5 4.0 Cc1ncn(C)c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(Cl)c3)C2)[nH]1 nan
CHEMBL4647456 184852 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 412 4 1 5 4.0 Cc1ncn(C)c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(Cl)c3)C2)[nH]1 nan
67497640 83610 0 None 3 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse GPR142 assessed as inositol phosphate accumulationAgonist activity at mouse GPR142 assessed as inositol phosphate accumulation
ChEMBL 334 5 3 4 1.9 N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O 10.1016/j.bmcl.2012.07.063
CHEMBL2069482 83610 0 None 3 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse GPR142 assessed as inositol phosphate accumulationAgonist activity at mouse GPR142 assessed as inositol phosphate accumulation
ChEMBL 334 5 3 4 1.9 N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O 10.1016/j.bmcl.2012.07.063
156013775 184053 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 491 6 1 5 4.0 Cc1ncn(CC2CN(C)C2)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
CHEMBL4636254 184053 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 491 6 1 5 4.0 Cc1ncn(CC2CN(C)C2)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
42171034 98510 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 420 7 1 8 3.2 COCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409024 98510 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 420 7 1 8 3.2 COCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
72165164 98497 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 421 7 1 8 3.3 CCCc1c(C(=O)NCc2cn(C)cn2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409010 98497 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 421 7 1 8 3.3 CCCc1c(C(=O)NCc2cn(C)cn2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
135218927 184118 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 488 5 1 6 4.7 Cc1ncn(C2CCC2)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)CCO2)[nH]1 10.1016/j.bmcl.2019.126857
CHEMBL4637374 184118 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 488 5 1 6 4.7 Cc1ncn(C2CCC2)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)CCO2)[nH]1 10.1016/j.bmcl.2019.126857
72945361 99152 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 421 8 2 7 4.0 O=C(Nc1cnc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2430988 99152 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 421 8 2 7 4.0 O=C(Nc1cnc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
73346302 99150 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 404 8 3 6 3.3 O=C(Nc1cc(-c2ccncc2)n[nH]1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2430985 99150 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 404 8 3 6 3.3 O=C(Nc1cc(-c2ccncc2)n[nH]1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
71453407 88711 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 425 8 2 9 2.7 Cn1cncc1-c1nnc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)s1 10.1016/j.bmcl.2012.08.015
CHEMBL2164858 88711 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 425 8 2 9 2.7 Cn1cncc1-c1nnc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)s1 10.1016/j.bmcl.2012.08.015
67496991 83647 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 417 8 2 6 3.9 Cn1cc(-c2cccc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)cn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069585 83647 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 417 8 2 6 3.9 Cn1cc(-c2cccc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)cn1 10.1016/j.bmcl.2012.07.063
67495836 83648 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 403 8 3 5 3.9 O=C(Nc1cccc(-c2cn[nH]c2)c1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069586 83648 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 403 8 3 5 3.9 O=C(Nc1cccc(-c2cn[nH]c2)c1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
73353866 99158 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 486 9 2 7 4.3 O=C(Nc1cc(-c2ccncc2)nn1CC(F)(F)F)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2431063 99158 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 486 9 2 7 4.3 O=C(Nc1cc(-c2ccncc2)nn1CC(F)(F)F)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
70684555 83645 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 417 8 2 6 3.9 Cn1ccc(-c2cccc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)n1 10.1016/j.bmcl.2012.07.063
CHEMBL2069583 83645 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 417 8 2 6 3.9 Cn1ccc(-c2cccc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)n1 10.1016/j.bmcl.2012.07.063
71455108 88705 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 471 8 3 6 4.0 Cc1nc(C2(N[C@@H](Cc3ccccc3)C(=O)Nc3cc(-c4ccncc4)c[nH]c3=O)CC2)cs1 10.1016/j.bmcl.2012.08.015
CHEMBL2164852 88705 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 471 8 3 6 4.0 Cc1nc(C2(N[C@@H](Cc3ccccc3)C(=O)Nc3cc(-c4ccncc4)c[nH]c3=O)CC2)cs1 10.1016/j.bmcl.2012.08.015
136232856 83651 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 420 8 4 6 2.6 O=C(Nc1cc(-c2ccn[nH]2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069589 83651 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 420 8 4 6 2.6 O=C(Nc1cc(-c2ccn[nH]2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
72163266 98503 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 466 8 1 8 5.0 CCCCc1c(C(=O)NCc2sc(C)nc2C)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409017 98503 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 466 8 1 8 5.0 CCCCc1c(C(=O)NCc2sc(C)nc2C)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
71455107 88695 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 480 8 3 6 2.4 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCC1CCS(=O)(=O)CC1 10.1016/j.bmcl.2012.08.015
CHEMBL2164842 88695 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 480 8 3 6 2.4 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCC1CCS(=O)(=O)CC1 10.1016/j.bmcl.2012.08.015
71456911 88691 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 428 8 3 6 2.5 Cn1ccc(CN[C@@H](Cc2ccccc2)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)n1 10.1016/j.bmcl.2012.08.015
CHEMBL2164838 88691 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 428 8 3 6 2.5 Cn1ccc(CN[C@@H](Cc2ccccc2)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)n1 10.1016/j.bmcl.2012.08.015
67496521 83644 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 429 8 3 6 4.1 Nc1cc(-c2cccc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)ccn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069582 83644 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 429 8 3 6 4.1 Nc1cc(-c2cccc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)ccn1 10.1016/j.bmcl.2012.07.063
72945163 99151 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 405 8 3 7 2.7 O=C(Nc1nnc(-c2ccncc2)[nH]1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2430986 99151 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 405 8 3 7 2.7 O=C(Nc1nnc(-c2ccncc2)[nH]1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
60207864 7858 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 438 8 1 9 2.2 CCOCc1c(cnn1c1ncc(c(n1)N1CCCCC1)C)C(=O)NCc1cncn1C 10.1021/ml400186z
8791 7858 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 438 8 1 9 2.2 CCOCc1c(cnn1c1ncc(c(n1)N1CCCCC1)C)C(=O)NCc1cncn1C 10.1021/ml400186z
CHEMBL2409007 7858 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 438 8 1 9 2.2 CCOCc1c(cnn1c1ncc(c(n1)N1CCCCC1)C)C(=O)NCc1cncn1C 10.1021/ml400186z
71462292 88699 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 439 8 3 5 3.7 C[C@H](N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O)c1ccccn1 10.1016/j.bmcl.2012.08.015
CHEMBL2164846 88699 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 439 8 3 5 3.7 C[C@H](N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O)c1ccccn1 10.1016/j.bmcl.2012.08.015
71458765 88689 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 429 8 3 6 3.1 Cc1cc(CN[C@@H](Cc2ccccc2)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)no1 10.1016/j.bmcl.2012.08.015
CHEMBL2164836 88689 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 429 8 3 6 3.1 Cc1cc(CN[C@@H](Cc2ccccc2)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)no1 10.1016/j.bmcl.2012.08.015
71462291 88698 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 431 8 4 5 1.9 O=C1CC[C@H](CN[C@@H](Cc2ccccc2)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)N1 10.1016/j.bmcl.2012.08.015
CHEMBL2164845 88698 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 431 8 4 5 1.9 O=C1CC[C@H](CN[C@@H](Cc2ccccc2)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)N1 10.1016/j.bmcl.2012.08.015
70693017 83652 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 434 8 3 7 2.6 Cn1cc(-c2c[nH]c(=O)c(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)cn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069590 83652 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 434 8 3 7 2.6 Cn1cc(-c2c[nH]c(=O)c(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)cn1 10.1016/j.bmcl.2012.07.063
67497024 83640 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 444 9 2 6 4.6 COc1ccc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc1-c1ccncc1 10.1016/j.bmcl.2012.07.063
CHEMBL2069578 83640 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 444 9 2 6 4.6 COc1ccc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc1-c1ccncc1 10.1016/j.bmcl.2012.07.063
72163406 98507 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 424 9 2 9 2.1 CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(NC2CCC2)n1 10.1021/ml400186z
CHEMBL2409021 98507 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 424 9 2 9 2.1 CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(NC2CCC2)n1 10.1021/ml400186z
72163409 98512 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 418 7 1 7 4.0 CCCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409026 98512 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 418 7 1 7 4.0 CCCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
70697097 83616 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 364 6 3 5 2.0 COc1ccc(C[C@H](N)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)cc1 10.1016/j.bmcl.2012.07.063
CHEMBL2069493 83616 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 364 6 3 5 2.0 COc1ccc(C[C@H](N)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)cc1 10.1016/j.bmcl.2012.07.063
67497915 99144 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 449 9 4 8 2.1 CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCc3c[nH]nn3)n(C)n2)ccn1 10.1021/ml4000854
CHEMBL2430979 99144 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 449 9 4 8 2.1 CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCc3c[nH]nn3)n(C)n2)ccn1 10.1021/ml4000854
71458768 88706 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 509 10 3 7 3.2 O=C(O)Cn1cc(-c2ccncc2)cc(NC(=O)[C@H](Cc2ccccc2)NC2(c3ccccn3)CC2)c1=O 10.1016/j.bmcl.2012.08.015
CHEMBL2164853 88706 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 509 10 3 7 3.2 O=C(O)Cn1cc(-c2ccncc2)cc(NC(=O)[C@H](Cc2ccccc2)NC2(c3ccccn3)CC2)c1=O 10.1016/j.bmcl.2012.08.015
72945162 99162 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 405 8 2 7 3.5 O=C(Nc1cc(-c2ccncc2)no1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2431067 99162 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 405 8 2 7 3.5 O=C(Nc1cc(-c2ccncc2)no1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
135219005 184082 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 414 4 1 6 3.2 Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(Cl)c3)CCO2)[nH]1 10.1016/j.bmcl.2019.126857
CHEMBL4636686 184082 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 414 4 1 6 3.2 Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(Cl)c3)CCO2)[nH]1 10.1016/j.bmcl.2019.126857
135219005 184082 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as IP1 accumulation incubated for 1 hr by IP-one HTRF assayAgonist activity at human GPR142 expressed in HEK293 cells assessed as IP1 accumulation incubated for 1 hr by IP-one HTRF assay
ChEMBL 414 4 1 6 3.2 Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(Cl)c3)CCO2)[nH]1 nan
CHEMBL4636686 184082 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as IP1 accumulation incubated for 1 hr by IP-one HTRF assayAgonist activity at human GPR142 expressed in HEK293 cells assessed as IP1 accumulation incubated for 1 hr by IP-one HTRF assay
ChEMBL 414 4 1 6 3.2 Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(Cl)c3)CCO2)[nH]1 nan
73355394 99159 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 430 7 1 7 3.1 O=C([C@H](Cc1ccccc1)NCc1cncs1)N1CCn2nc(-c3ccncc3)cc21 10.1021/ml4000854
CHEMBL2431064 99159 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 430 7 1 7 3.1 O=C([C@H](Cc1ccccc1)NCc1cncs1)N1CCn2nc(-c3ccncc3)cc21 10.1021/ml4000854
72163407 98508 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 410 8 1 9 1.4 CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(N2CCC2)n1 10.1021/ml400186z
CHEMBL2409022 98508 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 410 8 1 9 1.4 CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(N2CCC2)n1 10.1021/ml400186z
71462293 88707 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 522 11 2 7 3.7 CN(C)CCn1cc(-c2ccncc2)cc(NC(=O)[C@H](Cc2ccccc2)NC2(c3ccccn3)CC2)c1=O 10.1016/j.bmcl.2012.08.015
CHEMBL2164854 88707 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 522 11 2 7 3.7 CN(C)CCn1cc(-c2ccncc2)cc(NC(=O)[C@H](Cc2ccccc2)NC2(c3ccccn3)CC2)c1=O 10.1016/j.bmcl.2012.08.015
72945364 99155 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 421 8 2 7 4.0 O=C(Nc1csc(-c2ccncc2)n1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2431060 99155 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 421 8 2 7 4.0 O=C(Nc1csc(-c2ccncc2)n1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
67497939 83636 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 416 8 2 7 3.3 O=C(Nc1nccc(-c2ccncc2)n1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069574 83636 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 416 8 2 7 3.3 O=C(Nc1nccc(-c2ccncc2)n1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
70684556 83650 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 445 8 3 6 3.5 Cc1cc(-c2c[nH]c(=O)c(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)ccn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069588 83650 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 445 8 3 6 3.5 Cc1cc(-c2c[nH]c(=O)c(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)ccn1 10.1016/j.bmcl.2012.07.063
135218990 183963 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 464 5 1 7 3.4 Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(OC(F)(F)F)c3)CCO2)[nH]1 10.1016/j.bmcl.2019.126857
CHEMBL4634933 183963 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 464 5 1 7 3.4 Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(OC(F)(F)F)c3)CCO2)[nH]1 10.1016/j.bmcl.2019.126857
156020268 184838 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 422 4 1 4 4.0 Cc1ncn(C)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
CHEMBL4647315 184838 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 422 4 1 4 4.0 Cc1ncn(C)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
60207843 98499 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 449 8 1 8 4.0 CCCCc1c(C(=O)NCc2cnc(C)n2C)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409012 98499 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 449 8 1 8 4.0 CCCCc1c(C(=O)NCc2cnc(C)n2C)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
72163556 98517 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 434 8 1 8 3.6 CCOCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409030 98517 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 434 8 1 8 3.6 CCOCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
135218990 183963 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as IP1 accumulation incubated for 1 hr by IP-one HTRF assayAgonist activity at human GPR142 expressed in HEK293 cells assessed as IP1 accumulation incubated for 1 hr by IP-one HTRF assay
ChEMBL 464 5 1 7 3.4 Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(OC(F)(F)F)c3)CCO2)[nH]1 nan
CHEMBL4634933 183963 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as IP1 accumulation incubated for 1 hr by IP-one HTRF assayAgonist activity at human GPR142 expressed in HEK293 cells assessed as IP1 accumulation incubated for 1 hr by IP-one HTRF assay
ChEMBL 464 5 1 7 3.4 Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(OC(F)(F)F)c3)CCO2)[nH]1 nan
72165042 98519 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 446 8 0 7 4.7 CCCc1c(C(=O)N(CC)Cc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409032 98519 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 446 8 0 7 4.7 CCCc1c(C(=O)N(CC)Cc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
72945162 99162 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 405 8 2 7 3.5 O=C(Nc1cc(-c2ccncc2)no1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2431067 99162 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 405 8 2 7 3.5 O=C(Nc1cc(-c2ccncc2)no1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
134194565 184439 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 474 4 1 6 4.0 CN(C(=O)c1cccc(C(F)(F)F)c1)[C@@H]1CCC[C@H](c2nnc(-c3cnc4n3CCOC4)[nH]2)C1 10.1016/j.bmcl.2019.126857
CHEMBL4641575 184439 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 474 4 1 6 4.0 CN(C(=O)c1cccc(C(F)(F)F)c1)[C@@H]1CCC[C@H](c2nnc(-c3cnc4n3CCOC4)[nH]2)C1 10.1016/j.bmcl.2019.126857
70693016 83642 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 337 7 2 4 3.5 O=C(Nc1ccccc1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069580 83642 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 337 7 2 4 3.5 O=C(Nc1ccccc1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
135218876 184473 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 436 4 1 6 3.8 CN(C(=O)c1cccc(Cl)c1)[C@@H]1CCO[C@H](c2nnc(-c3cnc4ccccn34)[nH]2)C1 10.1016/j.bmcl.2019.126857
CHEMBL4641984 184473 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 436 4 1 6 3.8 CN(C(=O)c1cccc(Cl)c1)[C@@H]1CCO[C@H](c2nnc(-c3cnc4ccccn34)[nH]2)C1 10.1016/j.bmcl.2019.126857
67496855 88708 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 465 9 2 6 4.4 COc1ncc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NC1(c2ccccn2)CC1 10.1016/j.bmcl.2012.08.015
CHEMBL2164855 88708 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 465 9 2 6 4.4 COc1ncc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NC1(c2ccccn2)CC1 10.1016/j.bmcl.2012.08.015
69641837 88710 0 None -2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 451 9 3 9 3.4 CNc1cc(-c2nnc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)s2)ccn1 10.1016/j.bmcl.2012.08.015
CHEMBL2164857 88710 0 None -2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 451 9 3 9 3.4 CNc1cc(-c2nnc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)s2)ccn1 10.1016/j.bmcl.2012.08.015
67497939 83636 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 416 8 2 7 3.3 O=C(Nc1nccc(-c2ccncc2)n1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069574 83636 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 416 8 2 7 3.3 O=C(Nc1nccc(-c2ccncc2)n1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
73353862 99142 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 447 9 3 8 3.3 CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccccc3)NCc3cncs3)n(C)n2)ccn1 10.1021/ml4000854
CHEMBL2430977 99142 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 447 9 3 8 3.3 CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccccc3)NCc3cncs3)n(C)n2)ccn1 10.1021/ml4000854
73349343 99157 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 418 8 2 7 3.3 Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2431062 99157 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 418 8 2 7 3.3 Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
70693005 83612 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 368 5 3 4 2.6 N[C@@H](Cc1ccc(Cl)cc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O 10.1016/j.bmcl.2012.07.063
CHEMBL2069489 83612 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 368 5 3 4 2.6 N[C@@H](Cc1ccc(Cl)cc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O 10.1016/j.bmcl.2012.07.063
71462290 88696 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 418 8 3 5 2.8 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC[C@H]1CCCO1 10.1016/j.bmcl.2012.08.015
CHEMBL2164843 88696 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 418 8 3 5 2.8 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC[C@H]1CCCO1 10.1016/j.bmcl.2012.08.015
71449755 88712 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 428 8 2 9 3.5 O=C(Nc1nnc(-c2cncs2)s1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.08.015
CHEMBL2164859 88712 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 428 8 2 9 3.5 O=C(Nc1nnc(-c2cncs2)s1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.08.015
134194625 184502 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 496 6 1 5 5.1 Cc1ncn(CC(F)F)c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)C2)[nH]1 10.1016/j.bmcl.2019.126857
CHEMBL4642312 184502 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 496 6 1 5 5.1 Cc1ncn(CC(F)F)c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)C2)[nH]1 10.1016/j.bmcl.2019.126857
67497835 99146 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 426 9 4 7 1.9 CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCC(=O)O)n(C)n2)ccn1 10.1021/ml4000854
CHEMBL2430981 99146 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 426 9 4 7 1.9 CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCC(=O)O)n(C)n2)ccn1 10.1021/ml4000854
70682465 83613 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 352 5 3 4 2.1 N[C@@H](Cc1ccc(F)cc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O 10.1016/j.bmcl.2012.07.063
CHEMBL2069490 83613 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 352 5 3 4 2.1 N[C@@H](Cc1ccc(F)cc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O 10.1016/j.bmcl.2012.07.063
135205863 183864 2 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 448 4 1 6 3.5 Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)CCO2)[nH]1 10.1016/j.bmcl.2019.126857
CHEMBL4633161 183864 2 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 448 4 1 6 3.5 Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)CCO2)[nH]1 10.1016/j.bmcl.2019.126857
135205863 183864 2 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as IP1 accumulation incubated for 1 hr by IP-one HTRF assayAgonist activity at human GPR142 expressed in HEK293 cells assessed as IP1 accumulation incubated for 1 hr by IP-one HTRF assay
ChEMBL 448 4 1 6 3.5 Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)CCO2)[nH]1 nan
CHEMBL4633161 183864 2 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as IP1 accumulation incubated for 1 hr by IP-one HTRF assayAgonist activity at human GPR142 expressed in HEK293 cells assessed as IP1 accumulation incubated for 1 hr by IP-one HTRF assay
ChEMBL 448 4 1 6 3.5 Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)CCO2)[nH]1 nan
71451565 88693 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 426 8 3 6 2.6 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1ncccn1 10.1016/j.bmcl.2012.08.015
CHEMBL2164840 88693 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 426 8 3 6 2.6 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1ncccn1 10.1016/j.bmcl.2012.08.015
72945364 99155 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 421 8 2 7 4.0 O=C(Nc1csc(-c2ccncc2)n1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2431060 99155 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 421 8 2 7 4.0 O=C(Nc1csc(-c2ccncc2)n1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
134194661 184266 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 446 4 1 5 4.3 Cc1ncc(-c2nnc([C@H]3CCC[C@@H](N(C)C(=O)c4cccc(C(F)(F)F)c4)C3)[nH]2)n1C 10.1016/j.bmcl.2019.126857
CHEMBL4639333 184266 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 446 4 1 5 4.3 Cc1ncc(-c2nnc([C@H]3CCC[C@@H](N(C)C(=O)c4cccc(C(F)(F)F)c4)C3)[nH]2)n1C 10.1016/j.bmcl.2019.126857
70693006 83614 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 359 5 3 5 1.8 N#Cc1ccc(C[C@H](N)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)cc1 10.1016/j.bmcl.2012.07.063
CHEMBL2069491 83614 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 359 5 3 5 1.8 N#Cc1ccc(C[C@H](N)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)cc1 10.1016/j.bmcl.2012.07.063
69643233 83641 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 458 9 3 6 4.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2012.07.063
CHEMBL2069579 83641 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 458 9 3 6 4.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2012.07.063
67497640 83610 0 None -3 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 334 5 3 4 1.9 N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O 10.1016/j.bmcl.2012.08.015
CHEMBL2069482 83610 0 None -3 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 334 5 3 4 1.9 N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O 10.1016/j.bmcl.2012.08.015
67497640 83610 0 None -3 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 334 5 3 4 1.9 N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O 10.1016/j.bmcl.2012.07.063
CHEMBL2069482 83610 0 None -3 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 334 5 3 4 1.9 N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O 10.1016/j.bmcl.2012.07.063
73353863 99143 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 465 9 3 8 3.5 CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCc3cncs3)n(C)n2)ccn1 10.1021/ml4000854
CHEMBL2430978 99143 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 465 9 3 8 3.5 CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCc3cncs3)n(C)n2)ccn1 10.1021/ml4000854
72165041 98518 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 446 7 1 7 4.7 CCCc1c(C(=O)NC(C)(C)c2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409031 98518 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 446 7 1 7 4.7 CCCc1c(C(=O)NC(C)(C)c2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
70682472 83635 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 431 8 3 6 3.2 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069573 83635 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 431 8 3 6 3.2 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
73352401 99161 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 431 8 3 6 3.2 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2431066 99161 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 431 8 3 6 3.2 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
156016705 184438 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 521 7 1 6 3.8 Cc1ncn(CCN2CCOCC2)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
CHEMBL4641543 184438 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 521 7 1 6 3.8 Cc1ncn(CCN2CCOCC2)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
73346305 99160 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 462 10 3 8 2.8 O=C(O)Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2431065 99160 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 462 10 3 8 2.8 O=C(O)Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
67497264 83643 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 428 8 2 5 4.9 Cc1cc(-c2cccc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)ccn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069581 83643 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 428 8 2 5 4.9 Cc1cc(-c2cccc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)ccn1 10.1016/j.bmcl.2012.07.063
67496729 99148 0 None -1 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 379 8 3 6 1.7 Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCC(=O)O 10.1021/ml4000854
CHEMBL2430983 99148 0 None -1 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 379 8 3 6 1.7 Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCC(=O)O 10.1021/ml4000854
118319565 184489 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 462 6 1 4 4.9 Cc1ncn(CC2CC2)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
CHEMBL4642188 184489 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 462 6 1 4 4.9 Cc1ncn(CC2CC2)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
69642849 83639 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 444 9 2 6 4.6 COc1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2012.07.063
CHEMBL2069577 83639 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 444 9 2 6 4.6 COc1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2012.07.063
135219039 184640 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 460 4 1 6 3.6 CN(C(=O)c1cccc(C(F)(F)F)c1)[C@@H]1CCO[C@H](c2nnc(-c3cnc4n3CCC4)[nH]2)C1 10.1016/j.bmcl.2019.126857
CHEMBL4644313 184640 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 460 4 1 6 3.6 CN(C(=O)c1cccc(C(F)(F)F)c1)[C@@H]1CCO[C@H](c2nnc(-c3cnc4n3CCC4)[nH]2)C1 10.1016/j.bmcl.2019.126857
46853632 88703 0 None -29 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 451 8 3 5 3.7 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC1(c2ccccn2)CC1 10.1016/j.bmcl.2012.08.015
CHEMBL2164850 88703 0 None -29 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 451 8 3 5 3.7 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC1(c2ccccn2)CC1 10.1016/j.bmcl.2012.08.015
71456912 88700 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 439 8 3 5 3.7 C[C@@H](N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O)c1ccccn1 10.1016/j.bmcl.2012.08.015
CHEMBL2164847 88700 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 439 8 3 5 3.7 C[C@@H](N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O)c1ccccn1 10.1016/j.bmcl.2012.08.015
156019155 184762 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 472 6 1 4 4.7 Cc1ncn(CC(F)F)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
CHEMBL4646115 184762 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 472 6 1 4 4.7 Cc1ncn(CC(F)F)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
69641748 83649 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 413 8 2 4 5.2 O=C(Nc1cccc(-c2ccccc2)c1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069587 83649 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 413 8 2 4 5.2 O=C(Nc1cccc(-c2ccccc2)c1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
70686694 83615 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 348 5 3 4 2.3 Cc1ccc(C[C@H](N)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)cc1 10.1016/j.bmcl.2012.07.063
CHEMBL2069492 83615 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 348 5 3 4 2.3 Cc1ccc(C[C@H](N)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)cc1 10.1016/j.bmcl.2012.07.063
67497044 83637 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 414 8 2 5 4.5 O=C(Nc1cccc(-c2ccncc2)c1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069575 83637 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 414 8 2 5 4.5 O=C(Nc1cccc(-c2ccncc2)c1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
67496810 83646 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 403 8 3 5 3.9 O=C(Nc1cccc(-c2ccn[nH]2)c1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069584 83646 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 403 8 3 5 3.9 O=C(Nc1cccc(-c2ccn[nH]2)c1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
70684556 83650 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 445 8 3 6 3.5 Cc1cc(-c2c[nH]c(=O)c(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)ccn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069588 83650 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 445 8 3 6 3.5 Cc1cc(-c2c[nH]c(=O)c(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)ccn1 10.1016/j.bmcl.2012.07.063
60207837 98513 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 432 8 1 7 4.4 CCCCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409027 98513 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 432 8 1 7 4.4 CCCCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
67497965 99145 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 450 9 4 9 1.5 CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCc3nn[nH]n3)n(C)n2)ccn1 10.1021/ml4000854
CHEMBL2430980 99145 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 450 9 4 9 1.5 CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCc3nn[nH]n3)n(C)n2)ccn1 10.1021/ml4000854
118319567 184676 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 438 5 1 5 3.9 Cc1ncn(C)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(OC(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
CHEMBL4644869 184676 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 438 5 1 5 3.9 Cc1ncn(C)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(OC(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
71458767 88701 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 453 9 3 5 4.1 CCC(N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O)c1ccccn1 10.1016/j.bmcl.2012.08.015
CHEMBL2164848 88701 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 453 9 3 5 4.1 CCC(N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O)c1ccccn1 10.1016/j.bmcl.2012.08.015
72945362 99153 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 421 8 2 7 4.0 O=C(Nc1ncc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2431058 99153 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 421 8 2 7 4.0 O=C(Nc1ncc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
137285183 184619 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 432 4 2 4 4.3 Cc1nc[nH]c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)C2)[nH]1 10.1016/j.bmcl.2019.126857
CHEMBL4644081 184619 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 432 4 2 4 4.3 Cc1nc[nH]c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)C2)[nH]1 10.1016/j.bmcl.2019.126857
70695053 83617 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 388 8 3 4 3.0 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCC1CC1 10.1016/j.bmcl.2012.07.063
CHEMBL2069496 83617 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 388 8 3 4 3.0 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCC1CC1 10.1016/j.bmcl.2012.07.063
73349339 99147 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 425 9 4 7 1.3 CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCC(N)=O)n(C)n2)ccn1 10.1021/ml4000854
CHEMBL2430982 99147 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 425 9 4 7 1.3 CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCC(N)=O)n(C)n2)ccn1 10.1021/ml4000854
70695055 83619 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 438 9 3 4 3.8 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCCc1ccccc1 10.1016/j.bmcl.2012.07.063
CHEMBL2069498 83619 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 438 9 3 4 3.8 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCCc1ccccc1 10.1016/j.bmcl.2012.07.063
118319569 184955 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 490 5 1 4 5.0 Cc1ncn(CC(F)(F)F)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
CHEMBL4649204 184955 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 490 5 1 4 5.0 Cc1ncn(CC(F)(F)F)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
69642849 83639 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 444 9 2 6 4.6 COc1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2012.07.063
CHEMBL2069577 83639 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 444 9 2 6 4.6 COc1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2012.07.063
70695054 83618 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 424 8 3 4 3.8 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1ccccc1 10.1016/j.bmcl.2012.07.063
CHEMBL2069497 83618 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 424 8 3 4 3.8 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1ccccc1 10.1016/j.bmcl.2012.07.063
67497439 88709 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 422 8 2 8 3.4 O=C(Nc1nnc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.08.015
CHEMBL2164856 88709 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 422 8 2 8 3.4 O=C(Nc1nnc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.08.015
70697110 83638 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 444 9 2 6 4.6 COc1ccc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069576 83638 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 444 9 2 6 4.6 COc1ccc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
72945361 99152 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 421 8 2 7 4.0 O=C(Nc1cnc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2430988 99152 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 421 8 2 7 4.0 O=C(Nc1cnc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
73352401 99161 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 431 8 3 6 3.2 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2431066 99161 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 431 8 3 6 3.2 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
72163264 98502 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 435 8 1 8 3.7 CCCCc1c(C(=O)NCc2ccnn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
CHEMBL2409015 98502 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 435 8 1 8 3.7 CCCCc1c(C(=O)NCc2ccnn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 10.1021/ml400186z
70682472 83635 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 431 8 3 6 3.2 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069573 83635 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 431 8 3 6 3.2 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
118319555 183880 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 447 5 1 5 4.0 Cc1ncn(CC#N)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
CHEMBL4633342 183880 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay
ChEMBL 447 5 1 5 4.0 Cc1ncn(CC#N)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2019.126857
70682472 83635 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 431 8 3 6 3.2 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.08.015
CHEMBL2069573 83635 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 431 8 3 6 3.2 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.08.015
71460580 88702 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 453 8 3 5 3.9 CC(C)(N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O)c1ccccn1 10.1016/j.bmcl.2012.08.015
CHEMBL2164849 88702 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 453 8 3 5 3.9 CC(C)(N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O)c1ccccn1 10.1016/j.bmcl.2012.08.015
71460579 88692 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 425 8 3 5 3.2 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1ccccn1 10.1016/j.bmcl.2012.08.015
CHEMBL2164839 88692 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 425 8 3 5 3.2 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1ccccn1 10.1016/j.bmcl.2012.08.015
67497930 99149 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 407 9 2 7 2.2 CCOC(=O)CN[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)nn1C 10.1021/ml4000854
CHEMBL2430984 99149 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 407 9 2 7 2.2 CCOC(=O)CN[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)nn1C 10.1021/ml4000854
73346302 99150 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 404 8 3 6 3.3 O=C(Nc1cc(-c2ccncc2)n[nH]1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
CHEMBL2430985 99150 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting
ChEMBL 404 8 3 6 3.3 O=C(Nc1cc(-c2ccncc2)n[nH]1)[C@H](Cc1ccccc1)NCc1cncs1 10.1021/ml4000854
72163268 98506 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 399 9 1 9 1.6 CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(OCC)n1 10.1021/ml400186z
CHEMBL2409020 98506 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
ChEMBL 399 9 1 9 1.6 CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(OCC)n1 10.1021/ml400186z
67497044 83637 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 414 8 2 5 4.5 O=C(Nc1cccc(-c2ccncc2)c1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
CHEMBL2069575 83637 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 414 8 2 5 4.5 O=C(Nc1cccc(-c2ccncc2)c1)[C@H](Cc1ccccc1)NCc1cscn1 10.1016/j.bmcl.2012.07.063
67497024 83640 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 444 9 2 6 4.6 COc1ccc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc1-c1ccncc1 10.1016/j.bmcl.2012.07.063
CHEMBL2069578 83640 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum
ChEMBL 444 9 2 6 4.6 COc1ccc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc1-c1ccncc1 10.1016/j.bmcl.2012.07.063
71453406 88704 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 452 8 3 6 3.1 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC1(c2ncccn2)CC1 10.1016/j.bmcl.2012.08.015
CHEMBL2164851 88704 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation countingAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
ChEMBL 452 8 3 6 3.1 O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC1(c2ncccn2)CC1 10.1016/j.bmcl.2012.08.015
69641837 88710 0 None 2 2 Mouse 7.8 pIC50 = 7.8 Functional
Partial agonist activity at mouse GPR142 expressed in HEK293 cellsPartial agonist activity at mouse GPR142 expressed in HEK293 cells
ChEMBL 451 9 3 9 3.4 CNc1cc(-c2nnc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)s2)ccn1 10.1016/j.bmcl.2012.08.015
CHEMBL2164857 88710 0 None 2 2 Mouse 7.8 pIC50 = 7.8 Functional
Partial agonist activity at mouse GPR142 expressed in HEK293 cellsPartial agonist activity at mouse GPR142 expressed in HEK293 cells
ChEMBL 451 9 3 9 3.4 CNc1cc(-c2nnc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)s2)ccn1 10.1016/j.bmcl.2012.08.015
60207864 7858 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 8 1 9 2.2 CCOCc1c(cnn1c1ncc(c(n1)N1CCCCC1)C)C(=O)NCc1cncn1C 24900747
8791 7858 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 8 1 9 2.2 CCOCc1c(cnn1c1ncc(c(n1)N1CCCCC1)C)C(=O)NCc1cncn1C 24900747
CHEMBL2409007 7858 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 8 1 9 2.2 CCOCc1c(cnn1c1ncc(c(n1)N1CCCCC1)C)C(=O)NCc1cncn1C 24900747




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59472644 80314 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 438 6 1 7 4.2 COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
CHEMBL2017410 80314 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 438 6 1 7 4.2 COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
134131626 151984 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 416 6 1 7 3.7 COc1cc(-c2cn(CC(=O)Nc3cccc(C)c3C)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
CHEMBL3912504 151984 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 416 6 1 7 3.7 COc1cc(-c2cn(CC(=O)Nc3cccc(C)c3C)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
134135453 151155 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 426 5 1 6 4.4 Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 10.1021/acsmedchemlett.6b00314
CHEMBL3905835 151155 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 426 5 1 6 4.4 Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 10.1021/acsmedchemlett.6b00314
134149858 158905 0 None - 0 Mouse 7.9 pEC50 = 7.9 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 426 5 1 6 4.4 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 10.1021/acsmedchemlett.6b00314
CHEMBL3967871 158905 0 None - 0 Mouse 7.9 pEC50 = 7.9 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 426 5 1 6 4.4 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 10.1021/acsmedchemlett.6b00314
134149858 158905 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 426 5 1 6 4.4 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 10.1021/acsmedchemlett.6b00314
CHEMBL3967871 158905 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 426 5 1 6 4.4 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 10.1021/acsmedchemlett.6b00314
134152061 159917 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 412 5 1 6 4.1 O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl 10.1021/acsmedchemlett.6b00314
CHEMBL3976574 159917 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 412 5 1 6 4.1 O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl 10.1021/acsmedchemlett.6b00314
134152061 159917 0 None - 0 Mouse 7.8 pEC50 = 7.8 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 412 5 1 6 4.1 O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl 10.1021/acsmedchemlett.6b00314
CHEMBL3976574 159917 0 None - 0 Mouse 7.8 pEC50 = 7.8 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 412 5 1 6 4.1 O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl 10.1021/acsmedchemlett.6b00314
134133574 150039 0 None - 0 Mouse 7.7 pEC50 = 7.7 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 444 5 1 6 4.5 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 10.1021/acsmedchemlett.6b00314
CHEMBL3896713 150039 0 None - 0 Mouse 7.7 pEC50 = 7.7 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 444 5 1 6 4.5 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 10.1021/acsmedchemlett.6b00314
134149858 158905 0 None - 0 Mouse 7.7 pEC50 = 7.7 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 426 5 1 6 4.4 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 10.1021/acsmedchemlett.6b00314
CHEMBL3967871 158905 0 None - 0 Mouse 7.7 pEC50 = 7.7 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 426 5 1 6 4.4 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 10.1021/acsmedchemlett.6b00314
134132872 151481 0 None - 0 Mouse 6.7 pEC50 = 6.7 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 456 6 1 7 4.4 COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
CHEMBL3908606 151481 0 None - 0 Mouse 6.7 pEC50 = 6.7 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 456 6 1 7 4.4 COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
134151189 158626 0 None - 0 Mouse 8.7 pEC50 = 8.7 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 427 5 1 7 3.8 Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 10.1021/acsmedchemlett.6b00314
CHEMBL3965469 158626 0 None - 0 Mouse 8.7 pEC50 = 8.7 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 427 5 1 7 3.8 Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 10.1021/acsmedchemlett.6b00314
59472644 80314 0 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 438 6 1 7 4.2 COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
CHEMBL2017410 80314 0 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 438 6 1 7 4.2 COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
134151189 158626 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 427 5 1 7 3.8 Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 10.1021/acsmedchemlett.6b00314
CHEMBL3965469 158626 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 427 5 1 7 3.8 Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 10.1021/acsmedchemlett.6b00314
134151189 158626 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 427 5 1 7 3.8 Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 10.1021/acsmedchemlett.6b00314
CHEMBL3965469 158626 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 427 5 1 7 3.8 Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 10.1021/acsmedchemlett.6b00314
134135453 151155 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 426 5 1 6 4.4 Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 10.1021/acsmedchemlett.6b00314
CHEMBL3905835 151155 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 426 5 1 6 4.4 Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 10.1021/acsmedchemlett.6b00314
59472644 80314 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 438 6 1 7 4.2 COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
CHEMBL2017410 80314 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 438 6 1 7 4.2 COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
134152061 159917 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 412 5 1 6 4.1 O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl 10.1021/acsmedchemlett.6b00314
CHEMBL3976574 159917 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 412 5 1 6 4.1 O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl 10.1021/acsmedchemlett.6b00314
134135453 151155 0 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 426 5 1 6 4.4 Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 10.1021/acsmedchemlett.6b00314
CHEMBL3905835 151155 0 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 426 5 1 6 4.4 Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 10.1021/acsmedchemlett.6b00314
134135453 151155 0 None - 0 Mouse 8.5 pEC50 = 8.5 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 426 5 1 6 4.4 Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 10.1021/acsmedchemlett.6b00314
CHEMBL3905835 151155 0 None - 0 Mouse 8.5 pEC50 = 8.5 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 426 5 1 6 4.4 Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 10.1021/acsmedchemlett.6b00314
134152061 159917 0 None - 0 Mouse 8.5 pEC50 = 8.5 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 412 5 1 6 4.1 O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl 10.1021/acsmedchemlett.6b00314
CHEMBL3976574 159917 0 None - 0 Mouse 8.5 pEC50 = 8.5 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 412 5 1 6 4.1 O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl 10.1021/acsmedchemlett.6b00314
67496729 99148 0 None - 0 Mouse 7.5 pEC50 = 7.5 Binding
Agonist activity at mouse GPR142Agonist activity at mouse GPR142
ChEMBL 379 8 3 6 1.7 Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCC(=O)O 10.1021/ml4000854
CHEMBL2430983 99148 0 None - 0 Mouse 7.5 pEC50 = 7.5 Binding
Agonist activity at mouse GPR142Agonist activity at mouse GPR142
ChEMBL 379 8 3 6 1.7 Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCC(=O)O 10.1021/ml4000854
134135307 150871 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 444 5 1 6 4.5 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 10.1021/acsmedchemlett.6b00314
CHEMBL3903475 150871 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 444 5 1 6 4.5 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 10.1021/acsmedchemlett.6b00314
134149858 158905 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 426 5 1 6 4.4 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 10.1021/acsmedchemlett.6b00314
CHEMBL3967871 158905 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 426 5 1 6 4.4 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 10.1021/acsmedchemlett.6b00314
134132872 151481 0 None - 0 Mouse 7.4 pEC50 = 7.4 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 456 6 1 7 4.4 COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
CHEMBL3908606 151481 0 None - 0 Mouse 7.4 pEC50 = 7.4 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 456 6 1 7 4.4 COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
59472644 80314 0 None - 0 Mouse 7.4 pEC50 = 7.4 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 438 6 1 7 4.2 COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
CHEMBL2017410 80314 0 None - 0 Mouse 7.4 pEC50 = 7.4 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 438 6 1 7 4.2 COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
134135307 150871 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 444 5 1 6 4.5 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 10.1021/acsmedchemlett.6b00314
CHEMBL3903475 150871 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 444 5 1 6 4.5 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 10.1021/acsmedchemlett.6b00314
134132872 151481 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 456 6 1 7 4.4 COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
CHEMBL3908606 151481 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 456 6 1 7 4.4 COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
134137001 149926 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 440 5 0 6 4.4 Cc1nccn1-c1ccc(-c2cn(CC(=O)N(C)c3cccc(Cl)c3Cl)nn2)cc1 10.1021/acsmedchemlett.6b00314
CHEMBL3895853 149926 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 440 5 0 6 4.4 Cc1nccn1-c1ccc(-c2cn(CC(=O)N(C)c3cccc(Cl)c3Cl)nn2)cc1 10.1021/acsmedchemlett.6b00314
134133761 150056 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 440 6 1 6 4.4 Cc1nccn1Cc1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 10.1021/acsmedchemlett.6b00314
CHEMBL3896896 150056 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 440 6 1 6 4.4 Cc1nccn1Cc1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 10.1021/acsmedchemlett.6b00314
134145437 155539 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 424 6 1 7 3.4 COc1cc(-c2cn(CC(=O)Nc3cccc(F)c3F)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
CHEMBL3940492 155539 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 424 6 1 7 3.4 COc1cc(-c2cn(CC(=O)Nc3cccc(F)c3F)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
134133574 150039 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 444 5 1 6 4.5 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 10.1021/acsmedchemlett.6b00314
CHEMBL3896713 150039 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 444 5 1 6 4.5 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 10.1021/acsmedchemlett.6b00314
134131626 151984 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 416 6 1 7 3.7 COc1cc(-c2cn(CC(=O)Nc3cccc(C)c3C)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
CHEMBL3912504 151984 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 416 6 1 7 3.7 COc1cc(-c2cn(CC(=O)Nc3cccc(C)c3C)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
134133761 150056 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 440 6 1 6 4.4 Cc1nccn1Cc1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 10.1021/acsmedchemlett.6b00314
CHEMBL3896896 150056 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 440 6 1 6 4.4 Cc1nccn1Cc1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 10.1021/acsmedchemlett.6b00314
134133574 150039 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 444 5 1 6 4.5 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 10.1021/acsmedchemlett.6b00314
CHEMBL3896713 150039 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 444 5 1 6 4.5 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 10.1021/acsmedchemlett.6b00314
134132872 151481 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 456 6 1 7 4.4 COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
CHEMBL3908606 151481 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 456 6 1 7 4.4 COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
134135307 150871 0 None - 0 Mouse 7.1 pEC50 = 7.1 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 444 5 1 6 4.5 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 10.1021/acsmedchemlett.6b00314
CHEMBL3903475 150871 0 None - 0 Mouse 7.1 pEC50 = 7.1 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 444 5 1 6 4.5 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 10.1021/acsmedchemlett.6b00314
134133574 150039 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 444 5 1 6 4.5 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 10.1021/acsmedchemlett.6b00314
CHEMBL3896713 150039 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 444 5 1 6 4.5 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 10.1021/acsmedchemlett.6b00314
134151189 158626 0 None - 0 Mouse 8.1 pEC50 = 8.1 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 427 5 1 7 3.8 Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 10.1021/acsmedchemlett.6b00314
CHEMBL3965469 158626 0 None - 0 Mouse 8.1 pEC50 = 8.1 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 427 5 1 7 3.8 Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 10.1021/acsmedchemlett.6b00314
134131626 151984 0 None - 0 Mouse 7.1 pEC50 = 7.1 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 416 6 1 7 3.7 COc1cc(-c2cn(CC(=O)Nc3cccc(C)c3C)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
CHEMBL3912504 151984 0 None - 0 Mouse 7.1 pEC50 = 7.1 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 416 6 1 7 3.7 COc1cc(-c2cn(CC(=O)Nc3cccc(C)c3C)nn2)ccc1-n1cnc(C)c1 10.1021/acsmedchemlett.6b00314
134141648 153464 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 454 5 1 6 5.1 Cc1nccn1-c1ccc(-c2cn(C(C)(C)C(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 10.1021/acsmedchemlett.6b00314
CHEMBL3923863 153464 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay
ChEMBL 454 5 1 6 5.1 Cc1nccn1-c1ccc(-c2cn(C(C)(C)C(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 10.1021/acsmedchemlett.6b00314
134135307 150871 0 None - 0 Mouse 8.1 pEC50 = 8.1 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 444 5 1 6 4.5 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 10.1021/acsmedchemlett.6b00314
CHEMBL3903475 150871 0 None - 0 Mouse 8.1 pEC50 = 8.1 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay
ChEMBL 444 5 1 6 4.5 Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 10.1021/acsmedchemlett.6b00314
162658516 187843 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 404 3 0 6 5.2 Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4ccccc4Cl)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
CHEMBL4759692 187843 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 404 3 0 6 5.2 Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4ccccc4Cl)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
162661586 188245 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 397 2 1 2 5.6 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4764518 188245 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 397 2 1 2 5.6 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162667626 189337 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 379 2 1 3 4.8 O=C(Nc1cccc(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4787638 189337 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 379 2 1 3 4.8 O=C(Nc1cccc(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162664581 188988 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 359 2 1 5 3.2 N#Cc1cccc(NC(=O)N2CCOc3ccc(-n4ccnc4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4783052 188988 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 359 2 1 5 3.2 N#Cc1cccc(NC(=O)N2CCOc3ccc(-n4ccnc4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
162655529 187557 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 413 2 1 3 5.2 O=C(Nc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4756319 187557 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 413 2 1 3 5.2 O=C(Nc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162669605 189563 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 389 3 1 4 4.5 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4C)cc3C2)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4790417 189563 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 389 3 1 4 4.5 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4C)cc3C2)c1 10.1016/j.bmcl.2016.04.018
162647230 186525 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 363 2 1 3 4.3 O=C(Nc1ccc(F)cc1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4744210 186525 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 363 2 1 3 4.3 O=C(Nc1ccc(F)cc1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162664227 188852 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 363 2 1 3 4.3 O=C(Nc1ccccc1F)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4781462 188852 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 363 2 1 3 4.3 O=C(Nc1ccccc1F)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162653622 187293 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 397 2 1 3 5.0 O=C(Nc1ccc(F)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4753373 187293 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 397 2 1 3 5.0 O=C(Nc1ccc(F)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162655128 187495 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 413 2 1 3 5.5 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4755668 187495 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 413 2 1 3 5.5 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162655128 187495 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 413 2 1 3 5.5 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4755668 187495 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 413 2 1 3 5.5 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162664099 188965 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 412 2 2 3 5.5 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCNc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4782723 188965 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 412 2 2 3 5.5 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCNc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162656305 187607 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 437 4 1 4 6.0 O=C(Nc1cccc(Oc2ccccc2)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4756931 187607 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 437 4 1 4 6.0 O=C(Nc1cccc(Oc2ccccc2)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162653028 187161 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 448 4 0 4 4.5 O=S(=O)(Cc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4751751 187161 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 448 4 0 4 4.5 O=S(=O)(Cc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162654686 187378 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 413 2 1 3 5.5 O=C(Nc1cccc(Cl)c1Cl)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4754434 187378 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 413 2 1 3 5.5 O=C(Nc1cccc(Cl)c1Cl)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162655529 187557 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 413 2 1 3 5.2 O=C(Nc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4756319 187557 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 413 2 1 3 5.2 O=C(Nc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162664099 188965 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 412 2 2 3 5.5 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCNc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4782723 188965 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 412 2 2 3 5.5 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCNc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162645506 186375 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 376 3 1 5 3.6 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncn4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4742190 186375 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 376 3 1 5 3.6 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncn4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
162677474 190366 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 397 2 1 3 5.0 O=C(Nc1cccc(Cl)c1F)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4800653 190366 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 397 2 1 3 5.0 O=C(Nc1cccc(Cl)c1F)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162667626 189337 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 379 2 1 3 4.8 O=C(Nc1cccc(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4787638 189337 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 379 2 1 3 4.8 O=C(Nc1cccc(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162663630 188820 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 412 3 0 3 4.7 O=C(Cc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4781022 188820 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 412 3 0 3 4.7 O=C(Cc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162656305 187607 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 437 4 1 4 6.0 O=C(Nc1cccc(Oc2ccccc2)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4756931 187607 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 437 4 1 4 6.0 O=C(Nc1cccc(Oc2ccccc2)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162661586 188245 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 397 2 1 2 5.6 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4764518 188245 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 397 2 1 2 5.6 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162651006 187020 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 405 4 1 5 4.2 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4OC)cc3C2)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4750165 187020 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 405 4 1 5 4.2 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4OC)cc3C2)c1 10.1016/j.bmcl.2016.04.018
162663556 188703 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 425 3 1 4 5.3 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc5ccccc45)cc3C2)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4779679 188703 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 425 3 1 4 5.3 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc5ccccc45)cc3C2)c1 10.1016/j.bmcl.2016.04.018
162671374 189738 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 363 2 1 3 4.3 O=C(Nc1cccc(F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4792959 189738 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 363 2 1 3 4.3 O=C(Nc1cccc(F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162653028 187161 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 448 4 0 4 4.5 O=S(=O)(Cc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4751751 187161 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 448 4 0 4 4.5 O=S(=O)(Cc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162652305 187069 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 375 3 1 4 4.2 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4750832 187069 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 375 3 1 4 4.2 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
162645588 186270 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 405 4 1 5 4.2 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(OC)c4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4741033 186270 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 405 4 1 5 4.2 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(OC)c4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
162655503 187475 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 426 2 1 3 5.5 CN1CCN(C(=O)Nc2ccc(Cl)c(Cl)c2)Cc2cc(-c3ccncc3)ccc21 10.1016/j.bmcl.2016.04.018
CHEMBL4755519 187475 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 426 2 1 3 5.5 CN1CCN(C(=O)Nc2ccc(Cl)c(Cl)c2)Cc2cc(-c3ccncc3)ccc21 10.1016/j.bmcl.2016.04.018
162647230 186525 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 363 2 1 3 4.3 O=C(Nc1ccc(F)cc1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4744210 186525 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 363 2 1 3 4.3 O=C(Nc1ccc(F)cc1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162645588 186270 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 405 4 1 5 4.2 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(OC)c4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4741033 186270 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 405 4 1 5 4.2 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(OC)c4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
162676367 190122 0 None - 0 Mouse 5.5 pIC50 = 5.5 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 383 2 1 2 5.7 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCc2ccc(-c3ccncc3)cc21 10.1016/j.bmcl.2016.04.018
CHEMBL4797579 190122 0 None - 0 Mouse 5.5 pIC50 = 5.5 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 383 2 1 2 5.7 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCc2ccc(-c3ccncc3)cc21 10.1016/j.bmcl.2016.04.018
162652305 187069 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 375 3 1 4 4.2 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4750832 187069 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 375 3 1 4 4.2 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
162667324 189192 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 421 3 1 3 5.8 O=C(Nc1cccc(-c2ccccc2)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4785678 189192 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 421 3 1 3 5.8 O=C(Nc1cccc(-c2ccccc2)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162651111 187022 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 403 3 1 6 5.1 Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(Cl)c4)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
CHEMBL4750179 187022 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 403 3 1 6 5.1 Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(Cl)c4)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
162664539 188897 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 389 3 1 4 4.5 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(C)c4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4782047 188897 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 389 3 1 4 4.5 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(C)c4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
162669605 189563 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 389 3 1 4 4.5 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4C)cc3C2)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4790417 189563 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 389 3 1 4 4.5 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4C)cc3C2)c1 10.1016/j.bmcl.2016.04.018
162671374 189738 0 None - 0 Mouse 6.4 pIC50 = 6.4 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 363 2 1 3 4.3 O=C(Nc1cccc(F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4792959 189738 0 None - 0 Mouse 6.4 pIC50 = 6.4 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 363 2 1 3 4.3 O=C(Nc1cccc(F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162664225 188851 0 None - 0 Mouse 6.4 pIC50 = 6.4 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 385 2 2 5 3.6 N#Cc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(N)c4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4781458 188851 0 None - 0 Mouse 6.4 pIC50 = 6.4 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 385 2 2 5 3.6 N#Cc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(N)c4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
162676176 190231 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 453 4 1 7 5.4 Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(OC(F)(F)F)c4)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
CHEMBL4798957 190231 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 453 4 1 7 5.4 Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(OC(F)(F)F)c4)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
162646661 186298 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 468 5 1 3 6.7 CCCCN1CCN(C(=O)Nc2ccc(Cl)c(Cl)c2)Cc2cc(-c3ccncc3)ccc21 10.1016/j.bmcl.2016.04.018
CHEMBL4741265 186298 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 468 5 1 3 6.7 CCCCN1CCN(C(=O)Nc2ccc(Cl)c(Cl)c2)Cc2cc(-c3ccncc3)ccc21 10.1016/j.bmcl.2016.04.018
162668693 189538 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 423 3 1 6 5.2 FC(F)(F)c1cccc(Nc2nnc3n2CCOc2ccc(-c4ccncc4)cc2-3)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4790150 189538 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 423 3 1 6 5.2 FC(F)(F)c1cccc(Nc2nnc3n2CCOc2ccc(-c4ccncc4)cc2-3)c1 10.1016/j.bmcl.2016.04.018
162651006 187020 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 405 4 1 5 4.2 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4OC)cc3C2)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4750165 187020 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 405 4 1 5 4.2 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4OC)cc3C2)c1 10.1016/j.bmcl.2016.04.018
162658012 187897 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 375 3 1 4 4.2 COc1ccccc1NC(=O)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4760456 187897 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 375 3 1 4 4.2 COc1ccccc1NC(=O)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162648562 186699 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 422 3 0 6 5.3 Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4cccc(Cl)c4F)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
CHEMBL4746135 186699 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 422 3 0 6 5.3 Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4cccc(Cl)c4F)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
162659937 187980 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 404 3 0 6 5.2 Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4cccc(Cl)c4)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
CHEMBL4761139 187980 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 404 3 0 6 5.2 Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4cccc(Cl)c4)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
162677474 190366 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 397 2 1 3 5.0 O=C(Nc1cccc(Cl)c1F)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4800653 190366 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 397 2 1 3 5.0 O=C(Nc1cccc(Cl)c1F)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162646176 186474 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 411 2 1 2 6.0 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCCc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4743675 186474 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 411 2 1 2 6.0 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCCc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162648374 186578 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 402 3 0 5 5.0 Cc1cc(-c2ccc3c(c2)-c2nnc(Cc4cccc(Cl)c4)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
CHEMBL4744842 186578 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 402 3 0 5 5.0 Cc1cc(-c2ccc3c(c2)-c2nnc(Cc4cccc(Cl)c4)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
162664227 188852 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 363 2 1 3 4.3 O=C(Nc1ccccc1F)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4781462 188852 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 363 2 1 3 4.3 O=C(Nc1ccccc1F)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162663630 188820 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 412 3 0 3 4.7 O=C(Cc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4781022 188820 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 412 3 0 3 4.7 O=C(Cc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162653622 187293 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 397 2 1 3 5.0 O=C(Nc1ccc(F)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4753373 187293 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 397 2 1 3 5.0 O=C(Nc1ccc(F)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162667324 189192 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 421 3 1 3 5.8 O=C(Nc1cccc(-c2ccccc2)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4785678 189192 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 421 3 1 3 5.8 O=C(Nc1cccc(-c2ccccc2)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162655226 187469 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 439 4 1 7 5.0 FC(F)(F)Oc1cccc(Nc2nnc3n2CCOc2ccc(-c4ccncc4)cc2-3)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4755454 187469 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 439 4 1 7 5.0 FC(F)(F)Oc1cccc(Nc2nnc3n2CCOc2ccc(-c4ccncc4)cc2-3)c1 10.1016/j.bmcl.2016.04.018
162668988 189370 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 437 3 1 6 5.5 Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(C(F)(F)F)c4)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
CHEMBL4788072 189370 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 437 3 1 6 5.5 Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(C(F)(F)F)c4)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
162654686 187378 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 413 2 1 3 5.5 O=C(Nc1cccc(Cl)c1Cl)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4754434 187378 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 413 2 1 3 5.5 O=C(Nc1cccc(Cl)c1Cl)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162653296 187229 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 451 4 1 6 5.7 CCc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(C(F)(F)F)c4)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
CHEMBL4752684 187229 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 451 4 1 6 5.7 CCc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(C(F)(F)F)c4)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
162653133 187149 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 454 4 0 7 5.4 Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4cccc(OC(F)(F)F)c4)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
CHEMBL4751613 187149 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 454 4 0 7 5.4 Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4cccc(OC(F)(F)F)c4)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
162660699 188146 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 370 2 1 4 4.0 N#Cc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4763234 188146 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 370 2 1 4 4.0 N#Cc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
162663561 188718 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 345 2 1 3 4.2 O=C(Nc1ccccc1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4779820 188718 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 345 2 1 3 4.2 O=C(Nc1ccccc1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162660699 188146 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 370 2 1 4 4.0 N#Cc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4763234 188146 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 370 2 1 4 4.0 N#Cc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
162664225 188851 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 385 2 2 5 3.6 N#Cc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(N)c4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4781458 188851 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 385 2 2 5 3.6 N#Cc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(N)c4)cc3C2)c1 10.1016/j.bmcl.2016.04.018
162646176 186474 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 411 2 1 2 6.0 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCCc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4743675 186474 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 411 2 1 2 6.0 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCCc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162663561 188718 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 345 2 1 3 4.2 O=C(Nc1ccccc1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4779820 188718 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 345 2 1 3 4.2 O=C(Nc1ccccc1)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162645412 186467 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 454 4 0 7 5.4 Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4ccccc4OC(F)(F)F)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
CHEMBL4743615 186467 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 454 4 0 7 5.4 Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4ccccc4OC(F)(F)F)n2CCO3)ccn1 10.1016/j.bmcl.2016.04.018
162658012 187897 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 375 3 1 4 4.2 COc1ccccc1NC(=O)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
CHEMBL4760456 187897 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 375 3 1 4 4.2 COc1ccccc1NC(=O)N1CCOc2ccc(-c3ccncc3)cc2C1 10.1016/j.bmcl.2016.04.018
162663556 188703 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 425 3 1 4 5.3 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc5ccccc45)cc3C2)c1 10.1016/j.bmcl.2016.04.018
CHEMBL4779679 188703 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay
ChEMBL 425 3 1 4 5.3 COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc5ccccc45)cc3C2)c1 10.1016/j.bmcl.2016.04.018