Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 146293963 | 181564 | None | 0 | Human | Functional | pEC50 | = | 10.3 | 10.3 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 412 | 4 | 1 | 6 | 3.9 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3)c2)nn1 | nan | ||
| CHEMBL4764444 | 181564 | None | 0 | Human | Functional | pEC50 | = | 10.3 | 10.3 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 412 | 4 | 1 | 6 | 3.9 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3)c2)nn1 | nan | ||
| 67391041 | 91760 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay |
ChEMBL | 479 | 10 | 2 | 9 | 3.3 | CCCCc1c(C(=O)NCc2cncn2CC(=O)O)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409014 | 91760 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay |
ChEMBL | 479 | 10 | 2 | 9 | 3.3 | CCCCc1c(C(=O)NCc2cncn2CC(=O)O)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 146294019 | 180471 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 378 | 4 | 1 | 6 | 3.6 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(Cl)c3)c2)nn1 | nan | ||
| CHEMBL4751520 | 180471 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 378 | 4 | 1 | 6 | 3.6 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(Cl)c3)c2)nn1 | nan | ||
| 146293968 | 180846 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 442 | 5 | 1 | 7 | 4.1 | Cc1ccc(C(=O)Nc2cccc(OC(F)(F)F)c2)cc1-n1cc(-c2cncn2C)nn1 | nan | ||
| CHEMBL4755970 | 180846 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 442 | 5 | 1 | 7 | 4.1 | Cc1ccc(C(=O)Nc2cccc(OC(F)(F)F)c2)cc1-n1cc(-c2cncn2C)nn1 | nan | ||
| 146293961 | 180503 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 358 | 4 | 1 | 6 | 3.2 | Cc1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 | nan | ||
| CHEMBL4751970 | 180503 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 358 | 4 | 1 | 6 | 3.2 | Cc1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 | nan | ||
| 146293967 | 181606 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 392 | 4 | 1 | 6 | 3.9 | Cc1ccc(C(=O)Nc2cccc(Cl)c2)cc1-n1cc(-c2cncn2C)nn1 | nan | ||
| CHEMBL4764882 | 181606 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 392 | 4 | 1 | 6 | 3.9 | Cc1ccc(C(=O)Nc2cccc(Cl)c2)cc1-n1cc(-c2cncn2C)nn1 | nan | ||
| 146294023 | 179638 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 426 | 4 | 1 | 6 | 4.2 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-n1cc(-c2cncn2C)nn1 | nan | ||
| CHEMBL4741429 | 179638 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 426 | 4 | 1 | 6 | 4.2 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-n1cc(-c2cncn2C)nn1 | nan | ||
| 146293970 | 180093 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 430 | 4 | 1 | 6 | 4.1 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3F)c2)nn1 | nan | ||
| CHEMBL4746958 | 180093 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 430 | 4 | 1 | 6 | 4.1 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3F)c2)nn1 | nan | ||
| 146294020 | 182861 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 428 | 5 | 1 | 7 | 3.8 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)F)c3)c2)nn1 | nan | ||
| CHEMBL4790120 | 182861 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 428 | 5 | 1 | 7 | 3.8 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)F)c3)c2)nn1 | nan | ||
| 146293969 | 181257 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 426 | 4 | 1 | 6 | 4.2 | Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3)c2)nn1 | nan | ||
| CHEMBL4760780 | 181257 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 426 | 4 | 1 | 6 | 4.2 | Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3)c2)nn1 | nan | ||
| 146294026 | 179643 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 460 | 7 | 1 | 7 | 4.2 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)C(F)F)c3)c2)nn1 | nan | ||
| CHEMBL4741522 | 179643 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 460 | 7 | 1 | 7 | 4.2 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)C(F)F)c3)c2)nn1 | nan | ||
| 146294021 | 182497 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 442 | 5 | 1 | 7 | 4.1 | Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)F)c3)c2)nn1 | nan | ||
| CHEMBL4785317 | 182497 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 442 | 5 | 1 | 7 | 4.1 | Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)F)c3)c2)nn1 | nan | ||
| 146293959 | 179850 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 402 | 5 | 1 | 8 | 2.7 | COC(=O)c1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 | nan | ||
| CHEMBL4744201 | 179850 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 402 | 5 | 1 | 8 | 2.7 | COC(=O)c1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 | nan | ||
| 153044177 | 183582 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 369 | 4 | 1 | 7 | 2.8 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C#N)c3)c2)nn1 | nan | ||
| CHEMBL4799308 | 183582 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 369 | 4 | 1 | 7 | 2.8 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C#N)c3)c2)nn1 | nan | ||
| 153387722 | 183448 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 387 | 5 | 1 | 7 | 3.0 | CN(C)c1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 | nan | ||
| CHEMBL4797569 | 183448 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 387 | 5 | 1 | 7 | 3.0 | CN(C)c1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 | nan | ||
| 161475867 | 182972 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 374 | 5 | 1 | 7 | 2.9 | COc1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 | nan | ||
| CHEMBL4791730 | 182972 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 374 | 5 | 1 | 7 | 2.9 | COc1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 | nan | ||
| 146294022 | 181538 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 392 | 4 | 1 | 6 | 3.9 | Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(Cl)c3)c2)nn1 | nan | ||
| CHEMBL4764060 | 181538 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assayAgonist activity at human GPR142 receptor expressed in HEK293 cells assessed as increase in IP1 to accumulation incubated for 60 mins by HTRF assay |
ChEMBL | 392 | 4 | 1 | 6 | 3.9 | Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(Cl)c3)c2)nn1 | nan | ||
| 72165163 | 91755 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay |
ChEMBL | 435 | 8 | 1 | 8 | 3.7 | CCCCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409009 | 91755 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay |
ChEMBL | 435 | 8 | 1 | 8 | 3.7 | CCCCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 72165165 | 91757 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay |
ChEMBL | 449 | 8 | 1 | 8 | 4.0 | CCCCc1c(C(=O)NCc2c(C)ncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409011 | 91757 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay |
ChEMBL | 449 | 8 | 1 | 8 | 4.0 | CCCCc1c(C(=O)NCc2c(C)ncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 67390737 | 91763 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay |
ChEMBL | 437 | 8 | 1 | 9 | 2.9 | CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409019 | 91763 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay |
ChEMBL | 437 | 8 | 1 | 9 | 2.9 | CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 46853632 | 81959 | None | 0 | Mouse | Functional | pEC50 | = | 8.7 | 8.7 | 29 | 2 | Agonist activity at mouse GPR142 expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at mouse GPR142 expressed in HEK293 cells by inositol phosphate accumulation assay |
ChEMBL | 451 | 8 | 3 | 5 | 3.7 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC1(c2ccccn2)CC1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164850 | 81959 | None | 0 | Mouse | Functional | pEC50 | = | 8.7 | 8.7 | 29 | 2 | Agonist activity at mouse GPR142 expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at mouse GPR142 expressed in HEK293 cells by inositol phosphate accumulation assay |
ChEMBL | 451 | 8 | 3 | 5 | 3.7 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC1(c2ccccn2)CC1 | 10.1016/j.bmcl.2012.08.015 | ||
| 60207828 | 91759 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay |
ChEMBL | 475 | 7 | 1 | 8 | 4.6 | CCCCc1c(C(=O)NC2CCCc3ncn(C)c32)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409013 | 91759 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay |
ChEMBL | 475 | 7 | 1 | 8 | 4.6 | CCCCc1c(C(=O)NC2CCCc3ncn(C)c32)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 70697110 | 76891 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum |
ChEMBL | 444 | 9 | 2 | 6 | 4.6 | COc1ccc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069576 | 76891 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serumAgonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillation counting in presence of human serum |
ChEMBL | 444 | 9 | 2 | 6 | 4.6 | COc1ccc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 72163408 | 91770 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay |
ChEMBL | 404 | 6 | 1 | 7 | 3.6 | CCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409025 | 91770 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay |
ChEMBL | 404 | 6 | 1 | 7 | 3.6 | CCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 72163554 | 91773 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay |
ChEMBL | 446 | 9 | 1 | 7 | 4.8 | CCCCCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409028 | 91773 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assayAgonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay |
ChEMBL | 446 | 9 | 1 | 7 | 4.8 | CCCCCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
Showing 1 to 50 of 328 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 59472644 | 73565 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 438 | 6 | 1 | 7 | 4.2 | COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL2017410 | 73565 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 438 | 6 | 1 | 7 | 4.2 | COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134131626 | 145294 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 416 | 6 | 1 | 7 | 3.7 | COc1cc(-c2cn(CC(=O)Nc3cccc(C)c3C)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3912504 | 145294 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 416 | 6 | 1 | 7 | 3.7 | COc1cc(-c2cn(CC(=O)Nc3cccc(C)c3C)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134135453 | 144465 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3905835 | 144465 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134149858 | 152215 | None | 0 | Mouse | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3967871 | 152215 | None | 0 | Mouse | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134149858 | 152215 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3967871 | 152215 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134152061 | 153227 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 412 | 5 | 1 | 6 | 4.1 | O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3976574 | 153227 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 412 | 5 | 1 | 6 | 4.1 | O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.6b00314 | ||
| 134152061 | 153227 | None | 0 | Mouse | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 412 | 5 | 1 | 6 | 4.1 | O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3976574 | 153227 | None | 0 | Mouse | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 412 | 5 | 1 | 6 | 4.1 | O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.6b00314 | ||
| 134133574 | 143348 | None | 0 | Mouse | Binding | pEC50 | = | 7.7 | 7.7 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3896713 | 143348 | None | 0 | Mouse | Binding | pEC50 | = | 7.7 | 7.7 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134149858 | 152215 | None | 0 | Mouse | Binding | pEC50 | = | 7.7 | 7.7 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3967871 | 152215 | None | 0 | Mouse | Binding | pEC50 | = | 7.7 | 7.7 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134132872 | 144791 | None | 0 | Mouse | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 456 | 6 | 1 | 7 | 4.4 | COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3908606 | 144791 | None | 0 | Mouse | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 456 | 6 | 1 | 7 | 4.4 | COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134151189 | 151936 | None | 0 | Mouse | Binding | pEC50 | = | 8.7 | 8.7 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 427 | 5 | 1 | 7 | 3.8 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3965469 | 151936 | None | 0 | Mouse | Binding | pEC50 | = | 8.7 | 8.7 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 427 | 5 | 1 | 7 | 3.8 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 59472644 | 73565 | None | 0 | Mouse | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 438 | 6 | 1 | 7 | 4.2 | COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL2017410 | 73565 | None | 0 | Mouse | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 438 | 6 | 1 | 7 | 4.2 | COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134151189 | 151936 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 427 | 5 | 1 | 7 | 3.8 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3965469 | 151936 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 427 | 5 | 1 | 7 | 3.8 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134151189 | 151936 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 427 | 5 | 1 | 7 | 3.8 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3965469 | 151936 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 427 | 5 | 1 | 7 | 3.8 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134135453 | 144465 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3905835 | 144465 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| 59472644 | 73565 | None | 0 | Human | Binding | pEC50 | = | 6.6 | 6.6 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 438 | 6 | 1 | 7 | 4.2 | COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL2017410 | 73565 | None | 0 | Human | Binding | pEC50 | = | 6.6 | 6.6 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 438 | 6 | 1 | 7 | 4.2 | COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134152061 | 153227 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 412 | 5 | 1 | 6 | 4.1 | O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3976574 | 153227 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 412 | 5 | 1 | 6 | 4.1 | O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.6b00314 | ||
| 134135453 | 144465 | None | 0 | Mouse | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3905835 | 144465 | None | 0 | Mouse | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134135453 | 144465 | None | 0 | Mouse | Binding | pEC50 | = | 8.5 | 8.5 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3905835 | 144465 | None | 0 | Mouse | Binding | pEC50 | = | 8.5 | 8.5 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134152061 | 153227 | None | 0 | Mouse | Binding | pEC50 | = | 8.5 | 8.5 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 412 | 5 | 1 | 6 | 4.1 | O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3976574 | 153227 | None | 0 | Mouse | Binding | pEC50 | = | 8.5 | 8.5 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 412 | 5 | 1 | 6 | 4.1 | O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.6b00314 | ||
| 67496729 | 92425 | None | 0 | Mouse | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | Agonist activity at mouse GPR142Agonist activity at mouse GPR142 |
ChEMBL | 379 | 8 | 3 | 6 | 1.7 | Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCC(=O)O | 10.1021/ml4000854 | ||
| CHEMBL2430983 | 92425 | None | 0 | Mouse | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | Agonist activity at mouse GPR142Agonist activity at mouse GPR142 |
ChEMBL | 379 | 8 | 3 | 6 | 1.7 | Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCC(=O)O | 10.1021/ml4000854 | ||
| 134135307 | 144180 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3903475 | 144180 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134149858 | 152215 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3967871 | 152215 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134132872 | 144791 | None | 0 | Mouse | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 456 | 6 | 1 | 7 | 4.4 | COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3908606 | 144791 | None | 0 | Mouse | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assayAgonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ChEMBL | 456 | 6 | 1 | 7 | 4.4 | COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 59472644 | 73565 | None | 0 | Mouse | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 438 | 6 | 1 | 7 | 4.2 | COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL2017410 | 73565 | None | 0 | Mouse | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assayAgonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ChEMBL | 438 | 6 | 1 | 7 | 4.2 | COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
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