Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 11954197 | 166 | None | 27 | Human | Functional | pEC50 | = | 10.5 | 10.5 | 1 | 2 | Agonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 418 | 5 | 3 | 3 | 5.5 | O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C | 10.1016/j.bmcl.2016.09.029 | ||
| 4350 | 166 | None | 27 | Human | Functional | pEC50 | = | 10.5 | 10.5 | 1 | 2 | Agonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 418 | 5 | 3 | 3 | 5.5 | O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C | 10.1016/j.bmcl.2016.09.029 | ||
| CHEMBL4788348 | 166 | None | 27 | Human | Functional | pEC50 | = | 10.5 | 10.5 | 1 | 2 | Agonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 418 | 5 | 3 | 3 | 5.5 | O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C | 10.1016/j.bmcl.2016.09.029 | ||
| 162663790 | 182004 | None | 0 | Human | Functional | pEC50 | = | 10.0 | 10.0 | 15 | 2 | Agonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 486 | 5 | 3 | 3 | 6.4 | C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@]3(O)C(F)(F)F | 10.1016/j.bmcl.2016.09.029 | ||
| CHEMBL4779254 | 182004 | None | 0 | Human | Functional | pEC50 | = | 10.0 | 10.0 | 15 | 2 | Agonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 486 | 5 | 3 | 3 | 6.4 | C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@]3(O)C(F)(F)F | 10.1016/j.bmcl.2016.09.029 | ||
| 11954197 | 166 | None | 27 | Human | Functional | pEC50 | = | 9.9 | 9.9 | 1 | 2 | Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 418 | 5 | 3 | 3 | 5.5 | O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C | 10.1016/j.bmcl.2016.09.029 | ||
| 4350 | 166 | None | 27 | Human | Functional | pEC50 | = | 9.9 | 9.9 | 1 | 2 | Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 418 | 5 | 3 | 3 | 5.5 | O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C | 10.1016/j.bmcl.2016.09.029 | ||
| CHEMBL4788348 | 166 | None | 27 | Human | Functional | pEC50 | = | 9.9 | 9.9 | 1 | 2 | Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 418 | 5 | 3 | 3 | 5.5 | O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C | 10.1016/j.bmcl.2016.09.029 | ||
| 11954197 | 166 | None | 27 | Mouse | Functional | pEC50 | = | 9.2 | 9.2 | -1 | 2 | Agonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 418 | 5 | 3 | 3 | 5.5 | O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C | 10.1016/j.bmcl.2016.09.029 | ||
| 4350 | 166 | None | 27 | Mouse | Functional | pEC50 | = | 9.2 | 9.2 | -1 | 2 | Agonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 418 | 5 | 3 | 3 | 5.5 | O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C | 10.1016/j.bmcl.2016.09.029 | ||
| CHEMBL4788348 | 166 | None | 27 | Mouse | Functional | pEC50 | = | 9.2 | 9.2 | -1 | 2 | Agonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 418 | 5 | 3 | 3 | 5.5 | O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C | 10.1016/j.bmcl.2016.09.029 | ||
| 440985 | 182712 | None | 14 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 418 | 6 | 3 | 3 | 5.3 | CC(CO)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C | 10.1016/j.bmcl.2016.09.029 | ||
| CHEMBL4788277 | 182712 | None | 14 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 418 | 6 | 3 | 3 | 5.3 | CC(CO)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C | 10.1016/j.bmcl.2016.09.029 | ||
| 162663790 | 182004 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -15 | 2 | Agonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 486 | 5 | 3 | 3 | 6.4 | C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@]3(O)C(F)(F)F | 10.1016/j.bmcl.2016.09.029 | ||
| CHEMBL4779254 | 182004 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -15 | 2 | Agonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 486 | 5 | 3 | 3 | 6.4 | C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@]3(O)C(F)(F)F | 10.1016/j.bmcl.2016.09.029 | ||
| 107722 | 170 | None | 32 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | GPCR PRESTO-Tango dose-response in agonist mode with target: GPR183GPCR PRESTO-Tango dose-response in agonist mode with target: GPR183 |
ChEMBL | 402 | 5 | 2 | 2 | 6.4 | CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C | 10.6019/CHEMBL5442687 | ||
| 4351 | 170 | None | 32 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | GPCR PRESTO-Tango dose-response in agonist mode with target: GPR183GPCR PRESTO-Tango dose-response in agonist mode with target: GPR183 |
ChEMBL | 402 | 5 | 2 | 2 | 6.4 | CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C | 10.6019/CHEMBL5442687 | ||
| CHEMBL497207 | 170 | None | 32 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | GPCR PRESTO-Tango dose-response in agonist mode with target: GPR183GPCR PRESTO-Tango dose-response in agonist mode with target: GPR183 |
ChEMBL | 402 | 5 | 2 | 2 | 6.4 | CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C | 10.6019/CHEMBL5442687 | ||
| 162656664 | 180963 | None | 0 | Mouse | Functional | pEC50 | = | 7.8 | 7.8 | -3 | 2 | Agonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 486 | 5 | 3 | 3 | 6.4 | C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@@]3(O)C(F)(F)F | 10.1016/j.bmcl.2016.09.029 | ||
| CHEMBL4757291 | 180963 | None | 0 | Mouse | Functional | pEC50 | = | 7.8 | 7.8 | -3 | 2 | Agonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 486 | 5 | 3 | 3 | 6.4 | C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@@]3(O)C(F)(F)F | 10.1016/j.bmcl.2016.09.029 | ||
| 1599 | 2341 | None | 28 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -912 | 32 | GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183 |
ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | ||
| 3955 | 2341 | None | 28 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -912 | 32 | GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183 |
ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | ||
| 3955.0 | 2341 | None | 28 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -912 | 32 | GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183 |
ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | ||
| 7215 | 2341 | None | 28 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -912 | 32 | GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183 |
ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | ||
| CHEMBL841 | 2341 | None | 28 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -912 | 32 | GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183 |
ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | ||
| DB00836 | 2341 | None | 28 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -912 | 32 | GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183 |
ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | ||
| 4355 | 177 | None | 13 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 418 | 5 | 3 | 3 | 5.5 | O[C@H]1CC[C@]2(C(=C[C@@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C | 10.1016/j.bmcl.2016.09.029 | ||
| 473142 | 177 | None | 13 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 418 | 5 | 3 | 3 | 5.5 | O[C@H]1CC[C@]2(C(=C[C@@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C | 10.1016/j.bmcl.2016.09.029 | ||
| CHEMBL3311219 | 177 | None | 13 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 418 | 5 | 3 | 3 | 5.5 | O[C@H]1CC[C@]2(C(=C[C@@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C | 10.1016/j.bmcl.2016.09.029 | ||
| 162656664 | 180963 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 3 | 2 | Agonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 486 | 5 | 3 | 3 | 6.4 | C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@@]3(O)C(F)(F)F | 10.1016/j.bmcl.2016.09.029 | ||
| CHEMBL4757291 | 180963 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 3 | 2 | Agonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 486 | 5 | 3 | 3 | 6.4 | C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@@]3(O)C(F)(F)F | 10.1016/j.bmcl.2016.09.029 | ||
| 3036864 | 205211 | None | 16 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -12302 | 13 | GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183 |
ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.6019/CHEMBL5442687 | ||
| CHEMBL1256645 | 205211 | None | 16 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -12302 | 13 | GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183 |
ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.6019/CHEMBL5442687 | ||
| CHEMBL1814790 | 205211 | None | 16 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -12302 | 13 | GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183 |
ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.6019/CHEMBL5442687 | ||
| CHEMBL62 | 205211 | None | 16 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -12302 | 13 | GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183 |
ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.6019/CHEMBL5442687 | ||
| 67426622 | 181816 | None | 2 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 418 | 6 | 3 | 3 | 5.3 | CC(CO)CCC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@@H]3O | 10.1016/j.bmcl.2016.09.029 | ||
| CHEMBL4776911 | 181816 | None | 2 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysisAgonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis |
ChEMBL | 418 | 6 | 3 | 3 | 5.3 | CC(CO)CCC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@H](O)CC1=C[C@@H]3O | 10.1016/j.bmcl.2016.09.029 | ||
| 73330414 | 120997 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) |
ChEMBL | 432 | 3 | 0 | 2 | 4.1 | O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccc(Cl)cc2)CC1 | nan | ||
| CHEMBL3560809 | 120997 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) |
ChEMBL | 432 | 3 | 0 | 2 | 4.1 | O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccc(Cl)cc2)CC1 | nan | ||
| 13052 | 2820 | None | 48 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 3 | 2 | PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) |
ChEMBL | 428 | 4 | 0 | 3 | 3.5 | COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br | nan | ||
| 36295259 | 2820 | None | 48 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 3 | 2 | PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) |
ChEMBL | 428 | 4 | 0 | 3 | 3.5 | COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br | nan | ||
| CHEMBL3262896 | 2820 | None | 48 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 3 | 2 | PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) |
ChEMBL | 428 | 4 | 0 | 3 | 3.5 | COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br | nan | ||
| 73330413 | 120999 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) |
ChEMBL | 398 | 3 | 0 | 2 | 3.4 | O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccccc2)CC1 | nan | ||
| CHEMBL3560864 | 120999 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) |
ChEMBL | 398 | 3 | 0 | 2 | 3.4 | O=C(/C=C/c1ccc(Br)cc1)N1CCN(C(=O)c2ccccc2)CC1 | nan | ||
| 39566276 | 121001 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) |
ChEMBL | 412 | 3 | 0 | 2 | 3.8 | Cc1ccc(C(=O)N2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)cc1 | nan | ||
| CHEMBL3560888 | 121001 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) |
ChEMBL | 412 | 3 | 0 | 2 | 3.8 | Cc1ccc(C(=O)N2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)cc1 | nan | ||
| 73169083 | 120974 | None | 29 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) |
ChEMBL | 418 | 4 | 0 | 2 | 4.5 | O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccc(Cl)cc2)CC1 | nan | ||
| CHEMBL3560331 | 120974 | None | 29 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) |
ChEMBL | 418 | 4 | 0 | 2 | 4.5 | O=C(/C=C/c1ccc(Br)cc1)N1CCN(Cc2ccc(Cl)cc2)CC1 | nan | ||
| 13052 | 2820 | None | 48 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 3 | 2 | GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183 |
ChEMBL | 428 | 4 | 0 | 3 | 3.5 | COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br | 10.6019/CHEMBL5442687 | ||
| 36295259 | 2820 | None | 48 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 3 | 2 | GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183 |
ChEMBL | 428 | 4 | 0 | 3 | 3.5 | COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br | 10.6019/CHEMBL5442687 | ||
Showing 1 to 50 of 698 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 13052 | 2820 | None | 48 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis |
ChEMBL | 428 | 4 | 0 | 3 | 3.5 | COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br | 10.1021/jm4019355 | ||
| 36295259 | 2820 | None | 48 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis |
ChEMBL | 428 | 4 | 0 | 3 | 3.5 | COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br | 10.1021/jm4019355 | ||
| CHEMBL3262896 | 2820 | None | 48 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis |
ChEMBL | 428 | 4 | 0 | 3 | 3.5 | COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br | 10.1021/jm4019355 | ||
| 13052 | 2820 | None | 48 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis |
ChEMBL | 428 | 4 | 0 | 3 | 3.5 | COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br | 10.1021/jm4019355 | ||
| 36295259 | 2820 | None | 48 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis |
ChEMBL | 428 | 4 | 0 | 3 | 3.5 | COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br | 10.1021/jm4019355 | ||
| CHEMBL3262896 | 2820 | None | 48 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis |
ChEMBL | 428 | 4 | 0 | 3 | 3.5 | COC1=CC=C(C=C1)C(=O)N2CCN(CC2)C(=O)/C=C/C3=CC=C(C=C3)Br | 10.1021/jm4019355 | ||
| 1072081 | 111106 | None | 14 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis |
ChEMBL | 388 | 5 | 0 | 3 | 3.1 | O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 | 10.1021/jm4019355 | ||
| CHEMBL3262876 | 111106 | None | 14 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis |
ChEMBL | 388 | 5 | 0 | 3 | 3.1 | O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 | 10.1021/jm4019355 | ||
| 1072081 | 111106 | None | 14 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis |
ChEMBL | 388 | 5 | 0 | 3 | 3.1 | O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 | 10.1021/jm4019355 | ||
| CHEMBL3262876 | 111106 | None | 14 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysisAntagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis |
ChEMBL | 388 | 5 | 0 | 3 | 3.1 | O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 | 10.1021/jm4019355 | ||
| 1072081 | 111106 | None | 14 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | Displacement of [3H]-7-alpha,25-OHC from recombinant human EBI2 receptor expressed in CHO cells after 10 mins by scintillation counting analysisDisplacement of [3H]-7-alpha,25-OHC from recombinant human EBI2 receptor expressed in CHO cells after 10 mins by scintillation counting analysis |
ChEMBL | 388 | 5 | 0 | 3 | 3.1 | O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 | 10.1021/jm4019355 | ||
| CHEMBL3262876 | 111106 | None | 14 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | Displacement of [3H]-7-alpha,25-OHC from recombinant human EBI2 receptor expressed in CHO cells after 10 mins by scintillation counting analysisDisplacement of [3H]-7-alpha,25-OHC from recombinant human EBI2 receptor expressed in CHO cells after 10 mins by scintillation counting analysis |
ChEMBL | 388 | 5 | 0 | 3 | 3.1 | O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 | 10.1021/jm4019355 | ||
| 1072081 | 111106 | None | 14 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | Displacement of [3H]-7-alpha,25-OHC from recombinant human EBI2 receptor expressed in CHO cells after 10 mins by scintillation counting analysisDisplacement of [3H]-7-alpha,25-OHC from recombinant human EBI2 receptor expressed in CHO cells after 10 mins by scintillation counting analysis |
ChEMBL | 388 | 5 | 0 | 3 | 3.1 | O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 | 10.1021/jm4019355 | ||
| CHEMBL3262876 | 111106 | None | 14 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | Displacement of [3H]-7-alpha,25-OHC from recombinant human EBI2 receptor expressed in CHO cells after 10 mins by scintillation counting analysisDisplacement of [3H]-7-alpha,25-OHC from recombinant human EBI2 receptor expressed in CHO cells after 10 mins by scintillation counting analysis |
ChEMBL | 388 | 5 | 0 | 3 | 3.1 | O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)Cc2ccccc2)CC1 | 10.1021/jm4019355 | ||
| 126843232 | 1885 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | Measuring inhibition of [<sup>35</sup>S]GTPγS binding to hGPR183 in cell membrane preparationsMeasuring inhibition of [<sup>35</sup>S]GTPγS binding to hGPR183 in cell membrane preparations |
Guide to Pharmacology | 478 | 4 | 0 | 3 | 5.7 | C1CN(CCC12CN(C(=O)O2)CC3=CC(=C(C=C3)Cl)Cl)C(=O)/C=C/C4=CC=C(C=C4)Cl | 21673108 | ||
| 13053 | 1885 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | Measuring inhibition of [<sup>35</sup>S]GTPγS binding to hGPR183 in cell membrane preparationsMeasuring inhibition of [<sup>35</sup>S]GTPγS binding to hGPR183 in cell membrane preparations |
Guide to Pharmacology | 478 | 4 | 0 | 3 | 5.7 | C1CN(CCC12CN(C(=O)O2)CC3=CC(=C(C=C3)Cl)Cl)C(=O)/C=C/C4=CC=C(C=C4)Cl | 21673108 | ||
Showing 1 to 16 of 16 entries