Ligand source activities (1 row/activity)





Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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DOI

25209535 179373 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 570 7 1 8 4.5 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5C[C@H]6C[C@H]5CN6C)c(Cl)c4=O)c3C)cc2)cn1 10.1021/jm800962k
CHEMBL448975 179373 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 570 7 1 8 4.5 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5C[C@H]6C[C@H]5CN6C)c(Cl)c4=O)c3C)cc2)cn1 10.1021/jm800962k
25209192 182288 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 527 7 2 6 4.4 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)C(c1ccccc1)c1ccccc1 10.1021/jm800962k
CHEMBL457789 182288 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 527 7 2 6 4.4 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)C(c1ccccc1)c1ccccc1 10.1021/jm800962k
25208898 187238 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 558 7 1 8 4.3 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCN(C)CC5)c(Cl)c4=O)c3C)cc2)cn1 10.1021/jm800962k
CHEMBL475282 187238 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 558 7 1 8 4.3 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCN(C)CC5)c(Cl)c4=O)c3C)cc2)cn1 10.1021/jm800962k
44581974 182483 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 513 6 2 6 4.6 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1 10.1021/jm800962k
CHEMBL458220 182483 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 513 6 2 6 4.6 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1 10.1021/jm800962k
136036260 186823 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human MrgX1 receptorAgonist activity at human MrgX1 receptor
ChEMBL 623 7 2 7 5.9 CC(C)[C@H]1C(=O)Nc2ccc(NCCN3CCCCC3)cc2-c2nc3cc(C(=O)N4CCN(c5ccc(F)cc5)CC4)ccc3n21 10.1016/j.bmcl.2009.01.085
CHEMBL474761 186823 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human MrgX1 receptorAgonist activity at human MrgX1 receptor
ChEMBL 623 7 2 7 5.9 CC(C)[C@H]1C(=O)Nc2ccc(NCCN3CCCCC3)cc2-c2nc3cc(C(=O)N4CCN(c5ccc(F)cc5)CC4)ccc3n21 10.1016/j.bmcl.2009.01.085
25208894 179393 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 564 6 2 7 5.1 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccc3ncccc3c2)cc1 10.1021/jm800962k
CHEMBL449189 179393 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 564 6 2 7 5.1 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccc3ncccc3c2)cc1 10.1021/jm800962k
25209194 188413 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 519 6 2 7 4.6 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccsc2)cc1 10.1021/jm800962k
CHEMBL477432 188413 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 519 6 2 7 4.6 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccsc2)cc1 10.1021/jm800962k
25209050 188369 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 479 6 2 6 3.9 Cc1c(Cn2ncc(N3CCNCC3)cc2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1 10.1021/jm800962k
CHEMBL477008 188369 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 479 6 2 6 3.9 Cc1c(Cn2ncc(N3CCNCC3)cc2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1 10.1021/jm800962k
59819672 141729 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Activation of human MrgX1 receptor expressed in CHOK1/HEK293 cells assessed as stimulation of intracellular calcium mobilization by Fura-2 dye based fluorescence assayActivation of human MrgX1 receptor expressed in CHOK1/HEK293 cells assessed as stimulation of intracellular calcium mobilization by Fura-2 dye based fluorescence assay
ChEMBL 604 13 4 7 4.5 CN(CCc1ccccn1)C(=O)c1ccc2c(c1)nc(-c1cccc(Oc3ccccc3)c1)n2[C@@H](CCCNC(=N)N)C(N)=O nan
CHEMBL3719266 141729 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Activation of human MrgX1 receptor expressed in CHOK1/HEK293 cells assessed as stimulation of intracellular calcium mobilization by Fura-2 dye based fluorescence assayActivation of human MrgX1 receptor expressed in CHOK1/HEK293 cells assessed as stimulation of intracellular calcium mobilization by Fura-2 dye based fluorescence assay
ChEMBL 604 13 4 7 4.5 CN(CCc1ccccn1)C(=O)c1ccc2c(c1)nc(-c1cccc(Oc3ccccc3)c1)n2[C@@H](CCCNC(=N)N)C(N)=O nan
136036261 195531 0 None 10 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human MrgX1 receptorAgonist activity at human MrgX1 receptor
ChEMBL 632 9 3 6 7.1 CCC(C)[C@H]1C(=O)Nc2ccc(NCCN3CCCCC3)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 10.1016/j.bmcl.2009.01.085
CHEMBL505263 195531 0 None 10 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human MrgX1 receptorAgonist activity at human MrgX1 receptor
ChEMBL 632 9 3 6 7.1 CCC(C)[C@H]1C(=O)Nc2ccc(NCCN3CCCCC3)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 10.1016/j.bmcl.2009.01.085
25208743 182286 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 438 5 2 7 2.3 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1cccnc1 10.1021/jm800962k
CHEMBL457788 182286 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 438 5 2 7 2.3 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1cccnc1 10.1021/jm800962k
25209191 196320 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 455 5 2 6 3.1 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccccc1F 10.1021/jm800962k
CHEMBL514267 196320 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 455 5 2 6 3.1 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccccc1F 10.1021/jm800962k
25209048 186562 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 558 8 2 8 4.4 CNC1CCN(c2cnn(Cc3cccc(NC(=O)c4ccc(-c5ccc(OC)nc5)cc4)c3C)c(=O)c2Cl)C1 10.1021/jm800962k
CHEMBL474470 186562 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 558 8 2 8 4.4 CNC1CCN(c2cnn(Cc3cccc(NC(=O)c4ccc(-c5ccc(OC)nc5)cc4)c3C)c(=O)c2Cl)C1 10.1021/jm800962k
25209356 186564 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 544 7 2 8 4.0 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)c(Cl)c4=O)c3C)cc2)cn1 10.1021/jm800962k
CHEMBL474473 186564 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 544 7 2 8 4.0 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)c(Cl)c4=O)c3C)cc2)cn1 10.1021/jm800962k
59819658 140766 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Activation of human MrgX1 receptor expressed in CHOK1/HEK293 cells assessed as stimulation of intracellular calcium mobilization by Fura-2 dye based fluorescence assayActivation of human MrgX1 receptor expressed in CHOK1/HEK293 cells assessed as stimulation of intracellular calcium mobilization by Fura-2 dye based fluorescence assay
ChEMBL 658 11 4 7 5.4 Cc1cccc(N2CCN(C(=O)c3ccc4c(c3)nc(-c3cccc(Oc5ccccc5)c3)n4[C@@H](CCCNC(=N)N)C(N)=O)CC2C)c1 nan
CHEMBL3716029 140766 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Activation of human MrgX1 receptor expressed in CHOK1/HEK293 cells assessed as stimulation of intracellular calcium mobilization by Fura-2 dye based fluorescence assayActivation of human MrgX1 receptor expressed in CHOK1/HEK293 cells assessed as stimulation of intracellular calcium mobilization by Fura-2 dye based fluorescence assay
ChEMBL 658 11 4 7 5.4 Cc1cccc(N2CCN(C(=O)c3ccc4c(c3)nc(-c3cccc(Oc5ccccc5)c3)n4[C@@H](CCCNC(=N)N)C(N)=O)CC2C)c1 nan
59819634 141244 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Activation of human MrgX1 receptor expressed in CHOK1/HEK293 cells assessed as stimulation of intracellular calcium mobilization by Fura-2 dye based fluorescence assayActivation of human MrgX1 receptor expressed in CHOK1/HEK293 cells assessed as stimulation of intracellular calcium mobilization by Fura-2 dye based fluorescence assay
ChEMBL 648 11 4 7 4.9 N=C(N)NCCC[C@@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)N3CCN(c4ccc(F)cc4)CC3)ccc21 nan
CHEMBL3717645 141244 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Activation of human MrgX1 receptor expressed in CHOK1/HEK293 cells assessed as stimulation of intracellular calcium mobilization by Fura-2 dye based fluorescence assayActivation of human MrgX1 receptor expressed in CHOK1/HEK293 cells assessed as stimulation of intracellular calcium mobilization by Fura-2 dye based fluorescence assay
ChEMBL 648 11 4 7 4.9 N=C(N)NCCC[C@@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)N3CCN(c4ccc(F)cc4)CC3)ccc21 nan
136036258 195466 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human MrgX1 receptorAgonist activity at human MrgX1 receptor
ChEMBL 623 5 2 7 4.7 CC(=O)NC1CCN(c2ccc3c(c2)-c2nc4cc(C(=O)N5CCN(c6ccc(F)cc6)CC5)ccc4n2[C@@H](C(C)C)C(=O)N3)C1 10.1016/j.bmcl.2009.01.085
CHEMBL504032 195466 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human MrgX1 receptorAgonist activity at human MrgX1 receptor
ChEMBL 623 5 2 7 4.7 CC(=O)NC1CCN(c2ccc3c(c2)-c2nc4cc(C(=O)N5CCN(c6ccc(F)cc6)CC5)ccc4n2[C@@H](C(C)C)C(=O)N3)C1 10.1016/j.bmcl.2009.01.085
25208742 181698 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 443 5 2 6 3.2 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)C1CCCCC1 10.1021/jm800962k
CHEMBL456481 181698 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 443 5 2 6 3.2 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)C1CCCCC1 10.1021/jm800962k
25208744 196722 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 545 6 2 8 3.4 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)C1CCN(c2ccc(C#N)cc2)CC1 10.1021/jm800962k
CHEMBL517029 196722 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 545 6 2 8 3.4 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)C1CCN(c2ccc(C#N)cc2)CC1 10.1021/jm800962k
25209355 179704 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 564 6 2 7 5.1 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2cccc3cccnc23)cc1 10.1021/jm800962k
CHEMBL451657 179704 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 564 6 2 7 5.1 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2cccc3cccnc23)cc1 10.1021/jm800962k
25209047 188333 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 532 10 3 8 4.2 CNCCNc1cnn(Cc2cccc(NC(=O)c3ccc(-c4ccc(OC)nc4)cc3)c2C)c(=O)c1Cl 10.1021/jm800962k
CHEMBL476627 188333 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 532 10 3 8 4.2 CNCCNc1cnn(Cc2cccc(NC(=O)c3ccc(-c4ccc(OC)nc4)cc3)c2C)c(=O)c1Cl 10.1021/jm800962k
136036262 185222 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human MrgX1 receptorAgonist activity at human MrgX1 receptor
ChEMBL 652 14 4 8 5.6 CCC(C)[C@H]1C(=O)Nc2ccc(NCCOCCOCCN)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 10.1016/j.bmcl.2009.01.085
CHEMBL466116 185222 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human MrgX1 receptorAgonist activity at human MrgX1 receptor
ChEMBL 652 14 4 8 5.6 CCC(C)[C@H]1C(=O)Nc2ccc(NCCOCCOCCN)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 10.1016/j.bmcl.2009.01.085
136036237 195418 0 None 3 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human MrgX1 receptorAgonist activity at human MrgX1 receptor
ChEMBL 632 7 3 6 5.9 CCC(C)[C@H]1C(=O)Nc2ccc(N3CCC(NC(C)=O)C3)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 10.1016/j.bmcl.2009.01.085
CHEMBL503202 195418 0 None 3 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human MrgX1 receptorAgonist activity at human MrgX1 receptor
ChEMBL 632 7 3 6 5.9 CCC(C)[C@H]1C(=O)Nc2ccc(N3CCC(NC(C)=O)C3)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 10.1016/j.bmcl.2009.01.085
25209704 195049 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 586 7 1 8 4.2 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCN(C(C)=O)CC5)c(Cl)c4=O)c3C)cc2)cn1 10.1021/jm800962k
CHEMBL499944 195049 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 586 7 1 8 4.2 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCN(C(C)=O)CC5)c(Cl)c4=O)c3C)cc2)cn1 10.1021/jm800962k
59819673 141253 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Activation of human MrgX1 receptor expressed in CHOK1/HEK293 cells assessed as stimulation of intracellular calcium mobilization by Fura-2 dye based fluorescence assayActivation of human MrgX1 receptor expressed in CHOK1/HEK293 cells assessed as stimulation of intracellular calcium mobilization by Fura-2 dye based fluorescence assay
ChEMBL 590 13 5 7 4.2 N=C(N)NCCC[C@@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)NCCc3ccccn3)ccc21 nan
CHEMBL3717681 141253 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Activation of human MrgX1 receptor expressed in CHOK1/HEK293 cells assessed as stimulation of intracellular calcium mobilization by Fura-2 dye based fluorescence assayActivation of human MrgX1 receptor expressed in CHOK1/HEK293 cells assessed as stimulation of intracellular calcium mobilization by Fura-2 dye based fluorescence assay
ChEMBL 590 13 5 7 4.2 N=C(N)NCCC[C@@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)NCCc3ccccn3)ccc21 nan
25208895 186398 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 556 7 2 7 4.6 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2cccc(N(C)C)c2)cc1 10.1021/jm800962k
CHEMBL474272 186398 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 556 7 2 7 4.6 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2cccc(N(C)C)c2)cc1 10.1021/jm800962k
44581973 182380 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 513 6 2 6 4.6 Cc1ccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cc1NC(=O)c1ccc(-c2ccccc2)cc1 10.1021/jm800962k
CHEMBL458002 182380 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 513 6 2 6 4.6 Cc1ccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cc1NC(=O)c1ccc(-c2ccccc2)cc1 10.1021/jm800962k
25209354 188331 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 519 6 2 7 4.6 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1cccc(-c2ccsc2)c1 10.1021/jm800962k
CHEMBL476619 188331 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 519 6 2 7 4.6 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1cccc(-c2ccsc2)c1 10.1021/jm800962k
25209357 186567 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 556 7 3 7 3.7 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2cccc(C(N)=O)c2)cc1 10.1021/jm800962k
CHEMBL474474 186567 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 556 7 3 7 3.7 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2cccc(C(N)=O)c2)cc1 10.1021/jm800962k
25209536 179472 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 572 7 2 8 4.8 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CC(C)NC(C)C5)c(Cl)c4=O)c3C)cc2)cn1 10.1021/jm800962k
CHEMBL450183 179472 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 572 7 2 8 4.8 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CC(C)NC(C)C5)c(Cl)c4=O)c3C)cc2)cn1 10.1021/jm800962k
25209193 188412 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 519 6 2 7 4.6 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2cccs2)cc1 10.1021/jm800962k
CHEMBL477431 188412 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 519 6 2 7 4.6 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2cccs2)cc1 10.1021/jm800962k
25209705 187839 28 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 510 7 2 8 3.3 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)cc4=O)c3C)cc2)cn1 10.1021/jm800962k
CHEMBL475965 187839 28 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 510 7 2 8 3.3 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)cc4=O)c3C)cc2)cn1 10.1021/jm800962k
135407930 195199 0 None 10 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human MrgX1 receptorAgonist activity at human MrgX1 receptor
ChEMBL 606 10 3 6 6.6 CCC(C)[C@H]1C(=O)Nc2ccc(NCCCN(C)C)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 10.1016/j.bmcl.2009.01.085
CHEMBL502132 195199 0 None 10 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human MrgX1 receptorAgonist activity at human MrgX1 receptor
ChEMBL 606 10 3 6 6.6 CCC(C)[C@H]1C(=O)Nc2ccc(NCCCN(C)C)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 10.1016/j.bmcl.2009.01.085
135407979 195128 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human MrgX1 receptorAgonist activity at human MrgX1 receptor
ChEMBL 597 8 2 7 5.3 CC(C)[C@H]1C(=O)Nc2ccc(NCCCN(C)C)cc2-c2nc3cc(C(=O)N4CCN(c5ccc(F)cc5)CC4)ccc3n21 10.1016/j.bmcl.2009.01.085
CHEMBL501027 195128 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human MrgX1 receptorAgonist activity at human MrgX1 receptor
ChEMBL 597 8 2 7 5.3 CC(C)[C@H]1C(=O)Nc2ccc(NCCCN(C)C)cc2-c2nc3cc(C(=O)N4CCN(c5ccc(F)cc5)CC4)ccc3n21 10.1016/j.bmcl.2009.01.085
25209537 195068 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 587 8 3 9 2.8 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNC(C(N)=O)C5)c(Cl)c4=O)c3C)cc2)cn1 10.1021/jm800962k
CHEMBL500240 195068 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 587 8 3 9 2.8 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNC(C(N)=O)C5)c(Cl)c4=O)c3C)cc2)cn1 10.1021/jm800962k
CHEMBL506128 220981 21 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human MrgX1 receptorAgonist activity at human MrgX1 receptor
ChEMBL None None None None 10.1016/j.bmcl.2009.01.085
CHEMBL506884 220994 11 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL None None None None 10.1021/jm800962k
25209534 187067 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 558 7 2 8 4.4 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCCNCC5)c(Cl)c4=O)c3C)cc2)cn1 10.1021/jm800962k
CHEMBL475077 187067 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 558 7 2 8 4.4 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCCNCC5)c(Cl)c4=O)c3C)cc2)cn1 10.1021/jm800962k
25208745 188452 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 519 6 2 7 4.6 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1cccc(-c2cccs2)c1 10.1021/jm800962k
CHEMBL477643 188452 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 519 6 2 7 4.6 Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1cccc(-c2cccs2)c1 10.1021/jm800962k
44581972 182379 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 499 6 2 6 4.3 O=C(Nc1cccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)c1)c1ccc(-c2ccccc2)cc1 10.1021/jm800962k
CHEMBL458001 182379 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL 499 6 2 6 4.3 O=C(Nc1cccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)c1)c1ccc(-c2ccccc2)cc1 10.1021/jm800962k
46221497 142471 0 None -10 2 Rat 5.0 pIC50 = 5 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 408 6 0 3 5.4 N#Cc1cccc(CO[C@@H]2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 nan
CHEMBL3729794 142471 0 None -10 2 Rat 5.0 pIC50 = 5 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 408 6 0 3 5.4 N#Cc1cccc(CO[C@@H]2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 nan
11539085 121930 16 None -1 2 Rat 7.0 pIC50 = 7.0 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 423 6 0 3 5.7 COc1ccccc1C(=O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3343995 121930 16 None -1 2 Rat 7.0 pIC50 = 7.0 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 423 6 0 3 5.7 COc1ccccc1C(=O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
54581020 67797 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 571 10 1 7 4.1 CCN(Cc1ccncc1Br)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 10.1016/j.bmcl.2011.01.138
CHEMBL1762705 67797 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 571 10 1 7 4.1 CCN(Cc1ccncc1Br)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 10.1016/j.bmcl.2011.01.138
11641227 142569 0 None 3 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 462 5 1 3 6.7 O=C(Nc1cccc2ccccc12)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3730405 142569 0 None 3 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 462 5 1 3 6.7 O=C(Nc1cccc2ccccc12)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11503486 142939 0 None -3 2 Rat 5.9 pIC50 = 5.9 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 457 6 1 5 5.4 O=C(Nc1cccc([N+](=O)[O-])c1)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3732603 142939 0 None -3 2 Rat 5.9 pIC50 = 5.9 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 457 6 1 5 5.4 O=C(Nc1cccc([N+](=O)[O-])c1)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11691090 142172 0 None -11 2 Rat 4.9 pIC50 = 4.9 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 457 6 2 3 5.3 COc1ccccc1NC(=S)N[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3728009 142172 0 None -11 2 Rat 4.9 pIC50 = 4.9 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 457 6 2 3 5.3 COc1ccccc1NC(=S)N[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
54580026 67799 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 660 13 1 9 4.4 O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(CCCN1CCOCC1)Cc1c(Cl)cncc1Cl 10.1016/j.bmcl.2011.01.138
CHEMBL1762707 67799 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 660 13 1 9 4.4 O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(CCCN1CCOCC1)Cc1c(Cl)cncc1Cl 10.1016/j.bmcl.2011.01.138
11561403 142600 0 None 5 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 446 5 1 3 6.2 O=C(Nc1ccccc1Cl)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3730599 142600 0 None 5 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 446 5 1 3 6.2 O=C(Nc1ccccc1Cl)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
44210958 142532 0 None -14 2 Rat 5.8 pIC50 = 5.8 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 423 5 1 2 6.2 Cc1cc(C)cc(C(O)/C=C2\C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 nan
CHEMBL3730179 142532 0 None -14 2 Rat 5.8 pIC50 = 5.8 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 423 5 1 2 6.2 Cc1cc(C)cc(C(O)/C=C2\C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 nan
11676915 142082 1 None -10 2 Rat 6.8 pIC50 = 6.8 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 457 7 0 5 5.2 COc1ccc(C(=O)O[C@H]2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1OC nan
CHEMBL3727438 142082 1 None -10 2 Rat 6.8 pIC50 = 6.8 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 457 7 0 5 5.2 COc1ccc(C(=O)O[C@H]2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1OC nan
11552633 142803 0 None 1 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 379 5 0 1 6.1 C(\Cc1ccccc1)=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3731811 142803 0 None 1 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 379 5 0 1 6.1 C(\Cc1ccccc1)=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11618499 142158 0 None 3 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 413 5 1 2 5.7 OC(/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccc(F)cc1 nan
CHEMBL3727861 142158 0 None 3 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 413 5 1 2 5.7 OC(/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccc(F)cc1 nan
11718827 142625 0 None -2 2 Rat 6.7 pIC50 = 6.7 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 425 6 1 3 5.6 COc1ccccc1C(O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3730717 142625 0 None -2 2 Rat 6.7 pIC50 = 6.7 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 425 6 1 3 5.6 COc1ccccc1C(O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
54584943 67789 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 545 11 1 8 4.1 O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccncc1)Cc1ccco1 10.1016/j.bmcl.2011.01.138
CHEMBL1762698 67789 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 545 11 1 8 4.1 O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccncc1)Cc1ccco1 10.1016/j.bmcl.2011.01.138
44210958 142532 0 None 14 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 423 5 1 2 6.2 Cc1cc(C)cc(C(O)/C=C2\C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 nan
CHEMBL3730179 142532 0 None 14 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 423 5 1 2 6.2 Cc1cc(C)cc(C(O)/C=C2\C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 nan
46221497 142471 0 None 10 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 408 6 0 3 5.4 N#Cc1cccc(CO[C@@H]2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 nan
CHEMBL3729794 142471 0 None 10 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 408 6 0 3 5.4 N#Cc1cccc(CO[C@@H]2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 nan
11561740 142585 0 None -13 2 Rat 6.7 pIC50 = 6.7 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 463 5 1 2 6.6 OC(/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1cccc(C(F)(F)F)c1 nan
CHEMBL3730500 142585 0 None -13 2 Rat 6.7 pIC50 = 6.7 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 463 5 1 2 6.6 OC(/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1cccc(C(F)(F)F)c1 nan
54584944 67790 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 555 11 1 7 4.5 O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccccc1)Cc1ccncc1 10.1016/j.bmcl.2011.01.138
CHEMBL1762699 67790 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 555 11 1 7 4.5 O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccccc1)Cc1ccncc1 10.1016/j.bmcl.2011.01.138
11552633 142803 0 None -1 2 Rat 6.7 pIC50 = 6.7 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 379 5 0 1 6.1 C(\Cc1ccccc1)=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3731811 142803 0 None -1 2 Rat 6.7 pIC50 = 6.7 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 379 5 0 1 6.1 C(\Cc1ccccc1)=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11641227 142569 0 None -3 2 Rat 5.7 pIC50 = 5.7 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 462 5 1 3 6.7 O=C(Nc1cccc2ccccc12)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3730405 142569 0 None -3 2 Rat 5.7 pIC50 = 5.7 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 462 5 1 3 6.7 O=C(Nc1cccc2ccccc12)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11552633 142803 0 None -1 2 Rat 5.7 pIC50 = 5.7 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 379 5 0 1 6.1 C(\Cc1ccccc1)=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3731811 142803 0 None -1 2 Rat 5.7 pIC50 = 5.7 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 379 5 0 1 6.1 C(\Cc1ccccc1)=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
54581018 67792 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 624 11 1 8 5.2 O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccncc1)Cc1c(Cl)cncc1Cl 10.1016/j.bmcl.2011.01.138
CHEMBL1762700 67792 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 624 11 1 8 5.2 O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccncc1)Cc1c(Cl)cncc1Cl 10.1016/j.bmcl.2011.01.138
46221498 142262 3 None 2 2 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3728505 142262 3 None 2 2 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
54584945 67795 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 493 10 1 7 3.4 CCN(Cc1ccncc1)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 10.1016/j.bmcl.2011.01.138
CHEMBL1762703 67795 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 493 10 1 7 3.4 CCN(Cc1ccncc1)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 10.1016/j.bmcl.2011.01.138
127036914 142807 0 None 6 2 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 465 5 0 3 6.2 O=C(O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccccc1C(F)(F)F nan
CHEMBL3731844 142807 0 None 6 2 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 465 5 0 3 6.2 O=C(O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccccc1C(F)(F)F nan
11539607 143029 0 None -13 2 Rat 5.6 pIC50 = 5.6 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 446 5 1 3 6.2 O=C(Nc1ccccc1Cl)O[C@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3733177 143029 0 None -13 2 Rat 5.6 pIC50 = 5.6 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 446 5 1 3 6.2 O=C(Nc1ccccc1Cl)O[C@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11676915 142082 1 None -10 2 Rat 5.6 pIC50 = 5.6 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 457 7 0 5 5.2 COc1ccc(C(=O)O[C@H]2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1OC nan
CHEMBL3727438 142082 1 None -10 2 Rat 5.6 pIC50 = 5.6 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 457 7 0 5 5.2 COc1ccc(C(=O)O[C@H]2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1OC nan
11503486 142939 0 None 3 2 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 457 6 1 5 5.4 O=C(Nc1cccc([N+](=O)[O-])c1)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3732603 142939 0 None 3 2 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 457 6 1 5 5.4 O=C(Nc1cccc([N+](=O)[O-])c1)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11539607 143029 0 None -13 2 Rat 4.5 pIC50 = 4.5 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 446 5 1 3 6.2 O=C(Nc1ccccc1Cl)O[C@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3733177 143029 0 None -13 2 Rat 4.5 pIC50 = 4.5 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 446 5 1 3 6.2 O=C(Nc1ccccc1Cl)O[C@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
54581019 67796 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 519 11 1 7 3.7 O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccncc1)CC1CC1 10.1016/j.bmcl.2011.01.138
CHEMBL1762704 67796 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 519 11 1 7 3.7 O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccncc1)CC1CC1 10.1016/j.bmcl.2011.01.138
54584004 67787 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 431 9 3 6 3.1 NS(=O)(=O)c1ccc(CCNc2ccnc(NCCc3ccc(Cl)cc3)n2)cc1 10.1016/j.bmcl.2011.01.138
CHEMBL1762696 67787 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 431 9 3 6 3.1 NS(=O)(=O)c1ccc(CCNc2ccnc(NCCc3ccc(Cl)cc3)n2)cc1 10.1016/j.bmcl.2011.01.138
54585913 67798 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 492 10 1 6 4.0 CCN(Cc1ccccc1)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 10.1016/j.bmcl.2011.01.138
CHEMBL1762706 67798 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 492 10 1 6 4.0 CCN(Cc1ccccc1)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 10.1016/j.bmcl.2011.01.138
127036914 142807 0 None -6 2 Rat 5.5 pIC50 = 5.5 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 465 5 0 3 6.2 O=C(O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccccc1C(F)(F)F nan
CHEMBL3731844 142807 0 None -6 2 Rat 5.5 pIC50 = 5.5 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 465 5 0 3 6.2 O=C(O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccccc1C(F)(F)F nan
11618499 142158 0 None -3 2 Rat 6.5 pIC50 = 6.5 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 413 5 1 2 5.7 OC(/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccc(F)cc1 nan
CHEMBL3727861 142158 0 None -3 2 Rat 6.5 pIC50 = 6.5 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 413 5 1 2 5.7 OC(/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccc(F)cc1 nan
11561403 142600 0 None -5 2 Rat 5.4 pIC50 = 5.4 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 446 5 1 3 6.2 O=C(Nc1ccccc1Cl)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3730599 142600 0 None -5 2 Rat 5.4 pIC50 = 5.4 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 446 5 1 3 6.2 O=C(Nc1ccccc1Cl)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11539607 143029 0 None 13 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 446 5 1 3 6.2 O=C(Nc1ccccc1Cl)O[C@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3733177 143029 0 None 13 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 446 5 1 3 6.2 O=C(Nc1ccccc1Cl)O[C@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
54580024 67793 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 549 11 1 8 3.5 O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccncc1)CC1CCCO1 10.1016/j.bmcl.2011.01.138
CHEMBL1762701 67793 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 549 11 1 8 3.5 O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccncc1)CC1CCCO1 10.1016/j.bmcl.2011.01.138
11691090 142172 0 None 11 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 457 6 2 3 5.3 COc1ccccc1NC(=S)N[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3728009 142172 0 None 11 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 457 6 2 3 5.3 COc1ccccc1NC(=S)N[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
46221498 142262 3 None -2 2 Rat 6.3 pIC50 = 6.3 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3728505 142262 3 None -2 2 Rat 6.3 pIC50 = 6.3 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11618499 142158 0 None -3 2 Rat 5.3 pIC50 = 5.3 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 413 5 1 2 5.7 OC(/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccc(F)cc1 nan
CHEMBL3727861 142158 0 None -3 2 Rat 5.3 pIC50 = 5.3 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 413 5 1 2 5.7 OC(/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccc(F)cc1 nan
46221497 142471 0 None -10 2 Rat 6.3 pIC50 = 6.3 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 408 6 0 3 5.4 N#Cc1cccc(CO[C@@H]2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 nan
CHEMBL3729794 142471 0 None -10 2 Rat 6.3 pIC50 = 6.3 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 408 6 0 3 5.4 N#Cc1cccc(CO[C@@H]2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 nan
11539085 121930 16 None 1 2 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 423 6 0 3 5.7 COc1ccccc1C(=O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3343995 121930 16 None 1 2 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 423 6 0 3 5.7 COc1ccccc1C(=O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
46221498 142262 3 None -2 2 Rat 5.3 pIC50 = 5.3 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3728505 142262 3 None -2 2 Rat 5.3 pIC50 = 5.3 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
44210958 142532 0 None -14 2 Rat 5.3 pIC50 = 5.3 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 423 5 1 2 6.2 Cc1cc(C)cc(C(O)/C=C2\C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 nan
CHEMBL3730179 142532 0 None -14 2 Rat 5.3 pIC50 = 5.3 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 423 5 1 2 6.2 Cc1cc(C)cc(C(O)/C=C2\C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 nan
54585912 67784 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 627 11 2 8 4.0 CC(CN(C)C)NC(=O)C1CCN(S(=O)(=O)c2ccc3nc(NCCc4ccc(Cl)cc4)nc(N4CCCC4)c3c2)CC1 10.1016/j.bmcl.2011.01.138
CHEMBL1762693 67784 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 627 11 2 8 4.0 CC(CN(C)C)NC(=O)C1CCN(S(=O)(=O)c2ccc3nc(NCCc4ccc(Cl)cc4)nc(N4CCCC4)c3c2)CC1 10.1016/j.bmcl.2011.01.138
11718827 142625 0 None -2 2 Rat 6.3 pIC50 = 6.3 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 425 6 1 3 5.6 COc1ccccc1C(O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3730717 142625 0 None -2 2 Rat 6.3 pIC50 = 6.3 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 425 6 1 3 5.6 COc1ccccc1C(O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11661466 43690 0 None -1 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 408 6 0 3 5.4 N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 nan
CHEMBL145103 43690 0 None -1 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 408 6 0 3 5.4 N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 nan
11661466 43690 0 None -1 3 Rat 5.3 pIC50 = 5.3 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 408 6 0 3 5.4 N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 nan
CHEMBL145103 43690 0 None -1 3 Rat 5.3 pIC50 = 5.3 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 408 6 0 3 5.4 N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 nan
11503486 142939 0 None -3 2 Rat 5.2 pIC50 = 5.2 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 457 6 1 5 5.4 O=C(Nc1cccc([N+](=O)[O-])c1)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3732603 142939 0 None -3 2 Rat 5.2 pIC50 = 5.2 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 457 6 1 5 5.4 O=C(Nc1cccc([N+](=O)[O-])c1)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11661466 43690 0 None -1 3 Rat 6.2 pIC50 = 6.2 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 408 6 0 3 5.4 N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 nan
CHEMBL145103 43690 0 None -1 3 Rat 6.2 pIC50 = 6.2 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 408 6 0 3 5.4 N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 nan
11676915 142082 1 None 10 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 457 7 0 5 5.2 COc1ccc(C(=O)O[C@H]2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1OC nan
CHEMBL3727438 142082 1 None 10 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 457 7 0 5 5.2 COc1ccc(C(=O)O[C@H]2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1OC nan
54584003 67786 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 481 9 3 6 4.2 NS(=O)(=O)c1ccc(CCNc2nc(NCCc3ccc(Cl)cc3)nc3ccccc23)cc1 10.1016/j.bmcl.2011.01.138
CHEMBL1762695 67786 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 481 9 3 6 4.2 NS(=O)(=O)c1ccc(CCNc2nc(NCCc3ccc(Cl)cc3)nc3ccccc23)cc1 10.1016/j.bmcl.2011.01.138
11561740 142585 0 None -13 2 Rat 5.2 pIC50 = 5.2 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 463 5 1 2 6.6 OC(/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1cccc(C(F)(F)F)c1 nan
CHEMBL3730500 142585 0 None -13 2 Rat 5.2 pIC50 = 5.2 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 463 5 1 2 6.6 OC(/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1cccc(C(F)(F)F)c1 nan
11539085 121930 16 None -1 2 Rat 6.1 pIC50 = 6.1 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 423 6 0 3 5.7 COc1ccccc1C(=O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3343995 121930 16 None -1 2 Rat 6.1 pIC50 = 6.1 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 423 6 0 3 5.7 COc1ccccc1C(=O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11561403 142600 0 None -5 2 Rat 6.1 pIC50 = 6.1 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 446 5 1 3 6.2 O=C(Nc1ccccc1Cl)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3730599 142600 0 None -5 2 Rat 6.1 pIC50 = 6.1 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 446 5 1 3 6.2 O=C(Nc1ccccc1Cl)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
54584942 67788 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 442 7 1 6 2.9 O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N1CCCCC1 10.1016/j.bmcl.2011.01.138
CHEMBL1762697 67788 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 442 7 1 6 2.9 O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N1CCCCC1 10.1016/j.bmcl.2011.01.138
54586326 67346 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 561 10 1 7 4.7 CCN(Cc1c(Cl)cncc1Cl)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 10.1016/j.bmcl.2011.01.138
CHEMBL1760000 67346 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 561 10 1 7 4.7 CCN(Cc1c(Cl)cncc1Cl)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 10.1016/j.bmcl.2011.01.138
11718827 142625 0 None 2 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 425 6 1 3 5.6 COc1ccccc1C(O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3730717 142625 0 None 2 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 425 6 1 3 5.6 COc1ccccc1C(O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
54580023 67785 2 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 352 5 1 4 4.5 Clc1ccc(CCNc2nc(N3CCCC3)c3ccccc3n2)cc1 10.1016/j.bmcl.2011.01.138
CHEMBL1762694 67785 2 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 352 5 1 4 4.5 Clc1ccc(CCNc2nc(N3CCCC3)c3ccccc3n2)cc1 10.1016/j.bmcl.2011.01.138
54580025 67794 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 537 13 1 8 3.4 COCCCN(Cc1ccncc1)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 10.1016/j.bmcl.2011.01.138
CHEMBL1762702 67794 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayAntagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
ChEMBL 537 13 1 8 3.4 COCCCN(Cc1ccncc1)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 10.1016/j.bmcl.2011.01.138
127036914 142807 0 None -6 2 Rat 5.1 pIC50 = 5.1 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 465 5 0 3 6.2 O=C(O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccccc1C(F)(F)F nan
CHEMBL3731844 142807 0 None -6 2 Rat 5.1 pIC50 = 5.1 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp methodAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
ChEMBL 465 5 0 3 6.2 O=C(O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccccc1C(F)(F)F nan
11561740 142585 0 None 13 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 463 5 1 2 6.6 OC(/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1cccc(C(F)(F)F)c1 nan
CHEMBL3730500 142585 0 None 13 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assayAntagonist activity at MrgX1 (unknown origin) by beta-lactamase reporter gene assay
ChEMBL 463 5 1 2 6.6 OC(/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1cccc(C(F)(F)F)c1 nan
11641227 142569 0 None -3 2 Rat 6.0 pIC50 = 6.0 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 462 5 1 3 6.7 O=C(Nc1cccc2ccccc12)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3730405 142569 0 None -3 2 Rat 6.0 pIC50 = 6.0 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 462 5 1 3 6.7 O=C(Nc1cccc2ccccc12)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11691090 142172 0 None -11 2 Rat 5.0 pIC50 = 5.0 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 457 6 2 3 5.3 COc1ccccc1NC(=S)N[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3728009 142172 0 None -11 2 Rat 5.0 pIC50 = 5.0 Functional
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assayAntagonist activity at MrgX1 in mouse or rat DRG neurons assessed as intracellular Ca2+ level by FLIPR assay
ChEMBL 457 6 2 3 5.3 COc1ccccc1NC(=S)N[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
10482 7786 18 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human MRGPRX1 stably expressed in HEK293 cells by FLIPR claciun mobilisation assay.Agonist activity at human MRGPRX1 stably expressed in HEK293 cells by FLIPR claciun mobilisation assay.
Guide to Pharmacology 435 6 2 6 4.7 COc1ccccc1S(=O)(=O)Nc1ccc(cc1Oc1ccc2c(c1)ccnc2N)C 31498617
139030531 7786 18 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human MRGPRX1 stably expressed in HEK293 cells by FLIPR claciun mobilisation assay.Agonist activity at human MRGPRX1 stably expressed in HEK293 cells by FLIPR claciun mobilisation assay.
Guide to Pharmacology 435 6 2 6 4.7 COc1ccccc1S(=O)(=O)Nc1ccc(cc1Oc1ccc2c(c1)ccnc2N)C 31498617
CHEMBL4460098 7786 18 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human MRGPRX1 stably expressed in HEK293 cells by FLIPR claciun mobilisation assay.Agonist activity at human MRGPRX1 stably expressed in HEK293 cells by FLIPR claciun mobilisation assay.
Guide to Pharmacology 435 6 2 6 4.7 COc1ccccc1S(=O)(=O)Nc1ccc(cc1Oc1ccc2c(c1)ccnc2N)C 31498617
10567 8618 0 None -12 3 Human 4.7 pEC50 = 4.7 Functional
Determined in a FLIPR calcium imaging assay using HEK cells heterologously expressing hMRGPRX1Determined in a FLIPR calcium imaging assay using HEK cells heterologously expressing hMRGPRX1
Guide to Pharmacology None None None None 35704588
145996510 8618 0 None -12 3 Human 4.7 pEC50 = 4.7 Functional
Determined in a FLIPR calcium imaging assay using HEK cells heterologously expressing hMRGPRX1Determined in a FLIPR calcium imaging assay using HEK cells heterologously expressing hMRGPRX1
Guide to Pharmacology None None None None 35704588
2719 7704 74 None -45 2 Human 3.5 pEC50 = 3.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 319 8 1 3 4.8 CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC 20004959
5535 7704 74 None -45 2 Human 3.5 pEC50 = 3.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 319 8 1 3 4.8 CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC 20004959
607 7704 74 None -45 2 Human 3.5 pEC50 = 3.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 319 8 1 3 4.8 CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC 20004959
CHEMBL76 7704 74 None -45 2 Human 3.5 pEC50 = 3.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 319 8 1 3 4.8 CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC 20004959
DB00608 7704 74 None -45 2 Human 3.5 pEC50 = 3.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 319 8 1 3 4.8 CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC 20004959
101401182 7494 23 None 2 3 Human 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11850634
101401182 7494 23 None 2 3 Human 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15163697
101401182 7494 23 None 2 3 Human 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23396314
16158367 7494 23 None 2 3 Human 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11850634
16158367 7494 23 None 2 3 Human 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15163697
16158367 7494 23 None 2 3 Human 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23396314
4058 7494 23 None 2 3 Human 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11850634
4058 7494 23 None 2 3 Human 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15163697
4058 7494 23 None 2 3 Human 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23396314
CHEMBL3343989 7494 23 None 2 3 Human 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11850634
CHEMBL3343989 7494 23 None 2 3 Human 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15163697
CHEMBL3343989 7494 23 None 2 3 Human 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23396314




Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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DOI

155543843 181714 0 None - 1 Human 7.0 pEC50 = 7 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 411 7 3 5 3.9 COc1ccccc1S(=O)(=O)Nc1ccc(C)cc1Oc1ccc(C(=N)N)cc1 10.1021/acs.jmedchem.9b01003
CHEMBL4565294 181714 0 None - 1 Human 7.0 pEC50 = 7 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 411 7 3 5 3.9 COc1ccccc1S(=O)(=O)Nc1ccc(C)cc1Oc1ccc(C(=N)N)cc1 10.1021/acs.jmedchem.9b01003
CHEMBL5084093 221674 3 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL None None None CC(C)(C)c1sc2ncnc(Oc3ccccc3OC(F)(F)F)c2c1-c1ccc(Cl)c(Cl)c1 10.1021/acs.jmedchem.1c01709
59819634 141244 0 None - 0 Human 6.0 pEC50 = 6 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 648 11 4 7 4.9 N=C(N)NCCC[C@@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)N3CCN(c4ccc(F)cc4)CC3)ccc21 nan
CHEMBL3717645 141244 0 None - 0 Human 6.0 pEC50 = 6 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 648 11 4 7 4.9 N=C(N)NCCC[C@@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)N3CCN(c4ccc(F)cc4)CC3)ccc21 nan
59819672 141729 0 None - 0 Human 6.0 pEC50 = 6 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 604 13 4 7 4.5 CN(CCc1ccccn1)C(=O)c1ccc2c(c1)nc(-c1cccc(Oc3ccccc3)c1)n2[C@@H](CCCNC(=N)N)C(N)=O nan
CHEMBL3719266 141729 0 None - 0 Human 6.0 pEC50 = 6 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 604 13 4 7 4.5 CN(CCc1ccccn1)C(=O)c1ccc2c(c1)nc(-c1cccc(Oc3ccccc3)c1)n2[C@@H](CCCNC(=N)N)C(N)=O nan
168291043 198682 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 374 7 2 4 3.6 CCOc1ccccc1NC(=O)c1cc(C)ccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
CHEMBL5200001 198682 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 374 7 2 4 3.6 CCOc1ccccc1NC(=O)c1cc(C)ccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
168289487 198205 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 370 5 2 4 3.9 Cc1cc2cccc(NC(=O)c3ccccc3NS(=O)(=O)C3CC3)c2o1 10.1021/acsmedchemlett.2c00100
CHEMBL5192837 198205 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 370 5 2 4 3.9 Cc1cc2cccc(NC(=O)c3ccccc3NS(=O)(=O)C3CC3)c2o1 10.1021/acsmedchemlett.2c00100
168277932 197461 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 404 9 2 5 3.6 CCOc1ccc(NC(=O)c2ccccc2NS(=O)(=O)C2CC2)c(OCC)c1 10.1021/acsmedchemlett.2c00100
CHEMBL5181857 197461 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 404 9 2 5 3.6 CCOc1ccc(NC(=O)c2ccccc2NS(=O)(=O)C2CC2)c(OCC)c1 10.1021/acsmedchemlett.2c00100
CHEMBL5082858 221607 10 None - 0 Human 6.0 pEC50 = 6.0 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL None None None Cc1sc2ncnc(Oc3ccc(F)cc3)c2c1C 10.1021/acs.jmedchem.1c01709
71598556 197158 32 None - 0 Human 6.9 pEC50 = 6.9 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 360 7 2 4 3.2 CCOc1ccccc1NC(=O)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
CHEMBL5177388 197158 32 None - 0 Human 6.9 pEC50 = 6.9 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 360 7 2 4 3.2 CCOc1ccccc1NC(=O)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
118717468 121929 1 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL 368 8 6 4 0.1 N=C(N)Nc1ccc(C[C@@H](N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1016/j.bmc.2014.09.025
CHEMBL3343994 121929 1 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL 368 8 6 4 0.1 N=C(N)Nc1ccc(C[C@@H](N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1016/j.bmc.2014.09.025
168287582 198365 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 396 7 2 4 3.5 CCOc1ccc(F)cc1NC(=O)c1cc(F)ccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
CHEMBL5195160 198365 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 396 7 2 4 3.5 CCOc1ccc(F)cc1NC(=O)c1cc(F)ccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
168274093 197084 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 386 8 2 4 3.6 O=C(Nc1ccccc1OCC1CC1)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
CHEMBL5176049 197084 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 386 8 2 4 3.6 O=C(Nc1ccccc1OCC1CC1)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
168273467 196883 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 378 7 2 4 3.4 CCOc1ccc(F)cc1NC(=O)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
CHEMBL5172913 196883 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 378 7 2 4 3.4 CCOc1ccc(F)cc1NC(=O)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
168275005 197143 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 420 7 2 4 3.8 CCS(=O)(=O)Nc1ccccc1C(=O)Nc1ccc(F)cc1OCC(F)(F)F 10.1021/acsmedchemlett.2c00100
CHEMBL5177134 197143 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 420 7 2 4 3.8 CCS(=O)(=O)Nc1ccccc1C(=O)Nc1ccc(F)cc1OCC(F)(F)F 10.1021/acsmedchemlett.2c00100
168297110 199304 0 None - 0 Human 4.9 pEC50 = 4.9 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 356 5 2 4 3.6 O=C(Nc1cccc2occc12)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
CHEMBL5209542 199304 0 None - 0 Human 4.9 pEC50 = 4.9 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 356 5 2 4 3.6 O=C(Nc1cccc2occc12)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
710974 48739 10 None - 0 Human 4.8 pEC50 = 4.8 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL 242 2 0 4 3.8 Cc1ccccc1Oc1ncnc2sccc12 10.1021/acs.jmedchem.1c01709
CHEMBL1494771 48739 10 None - 0 Human 4.8 pEC50 = 4.8 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL 242 2 0 4 3.8 Cc1ccccc1Oc1ncnc2sccc12 10.1021/acs.jmedchem.1c01709
155524924 177706 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 465 7 3 5 4.8 Cc1ccc(NS(=O)(=O)c2ccccc2OC(F)(F)F)c(Oc2ccc(C(=N)N)cc2)c1 10.1021/acs.jmedchem.9b01003
CHEMBL4455263 177706 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 465 7 3 5 4.8 Cc1ccc(NS(=O)(=O)c2ccccc2OC(F)(F)F)c(Oc2ccc(C(=N)N)cc2)c1 10.1021/acs.jmedchem.9b01003
CHEMBL5078077 221313 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL None None None Cc1cc2c(Oc3ccccc3F)ncnc2s1 10.1021/acs.jmedchem.1c01709
59819673 141253 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 590 13 5 7 4.2 N=C(N)NCCC[C@@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)NCCc3ccccn3)ccc21 nan
CHEMBL3717681 141253 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 590 13 5 7 4.2 N=C(N)NCCC[C@@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)NCCc3ccccn3)ccc21 nan
89224504 141737 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 555 10 4 7 3.3 N=C(N)NCCC[C@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)N3CCOCC3)ccc21 nan
CHEMBL3719296 141737 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 555 10 4 7 3.3 N=C(N)NCCC[C@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)N3CCOCC3)ccc21 nan
118717467 121928 0 None - 0 Mouse 4.8 pEC50 = 4.8 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL 368 8 6 4 0.1 N=C(N)Nc1ccc(C[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1016/j.bmc.2014.09.025
CHEMBL3343993 121928 0 None - 0 Mouse 4.8 pEC50 = 4.8 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL 368 8 6 4 0.1 N=C(N)Nc1ccc(C[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1016/j.bmc.2014.09.025
155551191 180720 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 395 6 3 4 4.2 Cc1ccc(S(=O)(=O)Nc2ccc(C)cc2Oc2ccc(C(=N)N)cc2)cc1 10.1021/acs.jmedchem.9b01003
CHEMBL4541091 180720 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 395 6 3 4 4.2 Cc1ccc(S(=O)(=O)Nc2ccc(C)cc2Oc2ccc(C(=N)N)cc2)cc1 10.1021/acs.jmedchem.9b01003
CHEMBL5070279 221010 10 None - 0 Human 5.8 pEC50 = 5.8 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL None None None Cc1sc2ncnc(Oc3ccccc3)c2c1C 10.1021/acs.jmedchem.1c01709
CHEMBL5075377 221150 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL None None None Cc1csc2ncnc(Oc3ccccc3F)c12 10.1021/acs.jmedchem.1c01709
168297286 199257 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 378 7 2 4 3.4 CCOc1ccccc1NC(=O)c1cc(F)ccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
CHEMBL5208855 199257 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 378 7 2 4 3.4 CCOc1ccccc1NC(=O)c1cc(F)ccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
155530228 178292 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 341 9 3 4 4.0 COc1cc(CNc2ccc(C(=N)N)cc2)ccc1OCCC(C)C 10.1021/acs.jmedchem.9b01003
CHEMBL4464063 178292 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 341 9 3 4 4.0 COc1cc(CNc2ccc(C(=N)N)cc2)ccc1OCCC(C)C 10.1021/acs.jmedchem.9b01003
168289095 198080 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 400 7 2 4 3.9 CCOc1ccc(F)cc1NC(=O)c1cc(Cl)ccc1NS(=O)(=O)CC 10.1021/acsmedchemlett.2c00100
CHEMBL5191110 198080 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 400 7 2 4 3.9 CCOc1ccc(F)cc1NC(=O)c1cc(Cl)ccc1NS(=O)(=O)CC 10.1021/acsmedchemlett.2c00100
155563230 182086 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 399 6 3 4 4.0 Cc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(Oc2ccc(C(=N)N)cc2)c1 10.1021/acs.jmedchem.9b01003
CHEMBL4573405 182086 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 399 6 3 4 4.0 Cc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(Oc2ccc(C(=N)N)cc2)c1 10.1021/acs.jmedchem.9b01003
CHEMBL5077100 221259 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL None None None Fc1ccccc1Oc1ncnc2scc(C(F)(F)F)c12 10.1021/acs.jmedchem.1c01709
168296710 199007 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 362 7 2 4 3.4 CCOc1ccccc1NC(=O)c1cc(C)ccc1NS(=O)(=O)CC 10.1021/acsmedchemlett.2c00100
CHEMBL5205025 199007 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 362 7 2 4 3.4 CCOc1ccccc1NC(=O)c1cc(C)ccc1NS(=O)(=O)CC 10.1021/acsmedchemlett.2c00100
CHEMBL5080027 221438 3 None - 0 Human 6.7 pEC50 = 6.7 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL None None None Cc1sc2ncnc(Oc3ccccc3F)c2c1C 10.1021/acs.jmedchem.1c01709
155566258 182581 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 361 8 3 4 3.6 CCCCS(=O)(=O)Nc1ccc(C)cc1Oc1ccc(C(=N)N)cc1 10.1021/acs.jmedchem.9b01003
CHEMBL4584398 182581 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 361 8 3 4 3.6 CCCCS(=O)(=O)Nc1ccc(C)cc1Oc1ccc(C(=N)N)cc1 10.1021/acs.jmedchem.9b01003
CHEMBL5081104 221499 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL None None None CC(C)(C)c1sc2ncnc(Oc3ccccc3OC(F)(F)F)c2c1-c1ccc(F)cc1 10.1021/acs.jmedchem.1c01709
155546489 180338 0 None - 0 Human 4.6 pEC50 = 4.6 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 411 7 3 5 3.9 COc1ccccc1S(=O)(=O)Nc1ccc(C)cc1Oc1ccccc1C(=N)N 10.1021/acs.jmedchem.9b01003
CHEMBL4532285 180338 0 None - 0 Human 4.6 pEC50 = 4.6 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 411 7 3 5 3.9 COc1ccccc1S(=O)(=O)Nc1ccc(C)cc1Oc1ccccc1C(=N)N 10.1021/acs.jmedchem.9b01003
25209705 187839 28 None - 2 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL 510 7 2 8 3.3 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)cc4=O)c3C)cc2)cn1 10.1016/j.bmc.2014.09.025
CHEMBL475965 187839 28 None - 2 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL 510 7 2 8 3.3 COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)cc4=O)c3C)cc2)cn1 10.1016/j.bmc.2014.09.025
CHEMBL5085932 221781 16 None - 0 Human 4.6 pEC50 = 4.6 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL None None None Cc1cccc(Oc2ncnc3sc(C)c(C)c23)c1 10.1021/acs.jmedchem.1c01709
101401182 7494 23 None - 1 Mouse 6.6 pEC50 = 6.6 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2014.09.025
16158367 7494 23 None - 1 Mouse 6.6 pEC50 = 6.6 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2014.09.025
4058 7494 23 None - 1 Mouse 6.6 pEC50 = 6.6 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2014.09.025
CHEMBL3343989 7494 23 None - 1 Mouse 6.6 pEC50 = 6.6 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2014.09.025
89224506 141054 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 601 11 6 7 4.9 N=C(N)NCCC[C@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)Nc3ccc4cn[nH]c4c3)ccc21 nan
CHEMBL3716995 141054 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 601 11 6 7 4.9 N=C(N)NCCC[C@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)Nc3ccc4cn[nH]c4c3)ccc21 nan
24779707 141616 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 568 11 5 8 4.5 N=C(N)NCCC[C@@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)Nc3nccs3)ccc21 nan
CHEMBL3718857 141616 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 568 11 5 8 4.5 N=C(N)NCCC[C@@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)Nc3nccs3)ccc21 nan
CHEMBL5079109 221387 13 None - 0 Human 5.6 pEC50 = 5.6 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL None None None Cc1ccc(Oc2ncnc3sc(C)c(C)c23)cc1 10.1021/acs.jmedchem.1c01709
168289511 198275 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 374 7 2 4 3.6 CC(C)Oc1ccccc1NC(=O)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
CHEMBL5193744 198275 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 374 7 2 4 3.6 CC(C)Oc1ccccc1NC(=O)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
168293260 198919 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 366 7 2 4 3.2 CCOc1ccc(F)cc1NC(=O)c1ccccc1NS(=O)(=O)CC 10.1021/acsmedchemlett.2c00100
CHEMBL5203677 198919 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 366 7 2 4 3.2 CCOc1ccc(F)cc1NC(=O)c1ccccc1NS(=O)(=O)CC 10.1021/acsmedchemlett.2c00100
155517690 176971 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 367 8 3 5 4.2 COc1cc(CNc2ccc(C(=N)N)cc2)ccc1OCc1ccsc1 10.1021/acs.jmedchem.9b01003
CHEMBL4444915 176971 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 367 8 3 5 4.2 COc1cc(CNc2ccc(C(=N)N)cc2)ccc1OCc1ccsc1 10.1021/acs.jmedchem.9b01003
155523607 177679 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 347 8 3 4 3.3 CCCCS(=O)(=O)Nc1ccccc1Oc1ccc(C(=N)N)cc1 10.1021/acs.jmedchem.9b01003
CHEMBL4454684 177679 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 347 8 3 4 3.3 CCCCS(=O)(=O)Nc1ccccc1Oc1ccc(C(=N)N)cc1 10.1021/acs.jmedchem.9b01003
101401182 7494 23 None - 1 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse MRGPRC11Agonist activity at mouse MRGPRC11
ChEMBL None None None None 10.1021/acs.jmedchem.9b01003
16158367 7494 23 None - 1 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse MRGPRC11Agonist activity at mouse MRGPRC11
ChEMBL None None None None 10.1021/acs.jmedchem.9b01003
4058 7494 23 None - 1 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse MRGPRC11Agonist activity at mouse MRGPRC11
ChEMBL None None None None 10.1021/acs.jmedchem.9b01003
CHEMBL3343989 7494 23 None - 1 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse MRGPRC11Agonist activity at mouse MRGPRC11
ChEMBL None None None None 10.1021/acs.jmedchem.9b01003
101401182 7494 23 None - 1 Rat 6.5 pEC50 = 6.5 Binding
Agonist activity at rat MRGPRCAgonist activity at rat MRGPRC
ChEMBL None None None None 10.1021/acs.jmedchem.9b01003
16158367 7494 23 None - 1 Rat 6.5 pEC50 = 6.5 Binding
Agonist activity at rat MRGPRCAgonist activity at rat MRGPRC
ChEMBL None None None None 10.1021/acs.jmedchem.9b01003
4058 7494 23 None - 1 Rat 6.5 pEC50 = 6.5 Binding
Agonist activity at rat MRGPRCAgonist activity at rat MRGPRC
ChEMBL None None None None 10.1021/acs.jmedchem.9b01003
CHEMBL3343989 7494 23 None - 1 Rat 6.5 pEC50 = 6.5 Binding
Agonist activity at rat MRGPRCAgonist activity at rat MRGPRC
ChEMBL None None None None 10.1021/acs.jmedchem.9b01003
CHEMBL5076018 221187 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL None None None CC(C)(C)c1sc2ncnc(Oc3ccccc3F)c2c1-c1ccc(F)cc1 10.1021/acs.jmedchem.1c01709
CHEMBL5077884 221299 6 None - 0 Human 4.5 pEC50 = 4.5 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL None None None Cc1sc2ncnc(Oc3cccc(F)c3)c2c1C 10.1021/acs.jmedchem.1c01709
168295140 199043 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 384 7 2 4 3.4 CCOc1ccc(F)cc1NC(=O)c1cc(F)ccc1NS(=O)(=O)CC 10.1021/acsmedchemlett.2c00100
CHEMBL5205606 199043 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 384 7 2 4 3.4 CCOc1ccc(F)cc1NC(=O)c1cc(F)ccc1NS(=O)(=O)CC 10.1021/acsmedchemlett.2c00100
168294649 199165 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 400 7 2 4 4.2 O=C(Nc1ccccc1OC1CCCC1)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
CHEMBL5207586 199165 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 400 7 2 4 4.2 O=C(Nc1ccccc1OC1CCCC1)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
1486 10096 28 None - 2 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None NC(=N)NCCC[C@@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)NC(=O)C12CC3CC(C2)CC(C1)C3 10.1016/j.bmc.2014.09.025
53320361 10096 28 None - 2 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None NC(=N)NCCC[C@@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)NC(=O)C12CC3CC(C2)CC(C1)C3 10.1016/j.bmc.2014.09.025
CHEMBL1672380 10096 28 None - 2 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None NC(=N)NCCC[C@@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)NC(=O)C12CC3CC(C2)CC(C1)C3 10.1016/j.bmc.2014.09.025
101401182 7494 23 None - 1 Rat 6.5 pEC50 = 6.5 Binding
Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2014.09.025
16158367 7494 23 None - 1 Rat 6.5 pEC50 = 6.5 Binding
Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2014.09.025
4058 7494 23 None - 1 Rat 6.5 pEC50 = 6.5 Binding
Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2014.09.025
CHEMBL3343989 7494 23 None - 1 Rat 6.5 pEC50 = 6.5 Binding
Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2014.09.025
118717466 121927 0 None - 0 Mouse 4.5 pEC50 = 4.5 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL 354 7 6 4 0.2 N=C(N)Nc1cccc(C(N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1016/j.bmc.2014.09.025
CHEMBL3343992 121927 0 None - 0 Mouse 4.5 pEC50 = 4.5 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL 354 7 6 4 0.2 N=C(N)Nc1cccc(C(N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1016/j.bmc.2014.09.025
CHEMBL5094111 222251 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL None None None CC(C)(C)c1cc2c(Oc3ccccc3F)ncnc2s1 10.1021/acs.jmedchem.1c01709
155530554 178312 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 361 8 3 4 4.2 COc1cc(CNc2cccc(C(=N)N)c2)ccc1OCc1ccccc1 10.1021/acs.jmedchem.9b01003
CHEMBL4464286 178312 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 361 8 3 4 4.2 COc1cc(CNc2cccc(C(=N)N)c2)ccc1OCc1ccccc1 10.1021/acs.jmedchem.9b01003
CHEMBL5092430 222146 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL None None None CC(C)(C)c1sc2ncnc(Oc3ccccc3F)c2c1-c1ccccc1 10.1021/acs.jmedchem.1c01709
155544956 180195 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 411 7 3 5 3.9 COc1ccccc1S(=O)(=O)Nc1ccc(C)cc1Oc1cccc(C(=N)N)c1 10.1021/acs.jmedchem.9b01003
CHEMBL4528536 180195 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 411 7 3 5 3.9 COc1ccccc1S(=O)(=O)Nc1ccc(C)cc1Oc1cccc(C(=N)N)c1 10.1021/acs.jmedchem.9b01003
168275106 197335 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 436 7 2 4 4.3 CCS(=O)(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccccc1OCC(F)(F)F 10.1021/acsmedchemlett.2c00100
CHEMBL5179980 197335 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 436 7 2 4 4.3 CCS(=O)(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccccc1OCC(F)(F)F 10.1021/acsmedchemlett.2c00100
168272667 197220 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 428 7 2 4 4.1 Cc1ccc(NS(=O)(=O)C2CC2)c(C(=O)Nc2ccccc2OCC(F)(F)F)c1 10.1021/acsmedchemlett.2c00100
CHEMBL5178316 197220 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 428 7 2 4 4.1 Cc1ccc(NS(=O)(=O)C2CC2)c(C(=O)Nc2ccccc2OCC(F)(F)F)c1 10.1021/acsmedchemlett.2c00100
155536163 178953 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 385 7 2 5 5.0 COc1cc(CNc2ccc3c(N)nccc3c2)ccc1OCc1ccccc1 10.1021/acs.jmedchem.9b01003
CHEMBL4473501 178953 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 385 7 2 5 5.0 COc1cc(CNc2ccc3c(N)nccc3c2)ccc1OCc1ccccc1 10.1021/acs.jmedchem.9b01003
127024460 141325 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 643 12 5 6 5.7 N=C(N)NCCC[C@@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccc21 nan
CHEMBL3717941 141325 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 643 12 5 6 5.7 N=C(N)NCCC[C@@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccc21 nan
118717464 121924 0 None - 0 Rat 5.4 pEC50 = 5.4 Binding
Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL 346 6 5 4 -0.9 N=C(N)N1CCC(C(N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)CC1 10.1016/j.bmc.2014.09.025
CHEMBL3343988 121924 0 None - 0 Rat 5.4 pEC50 = 5.4 Binding
Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL 346 6 5 4 -0.9 N=C(N)N1CCC(C(N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)CC1 10.1016/j.bmc.2014.09.025
168276836 196928 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 382 7 2 4 3.8 CCOc1ccccc1NC(=O)c1cc(Cl)ccc1NS(=O)(=O)CC 10.1021/acsmedchemlett.2c00100
CHEMBL5173653 196928 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 382 7 2 4 3.8 CCOc1ccccc1NC(=O)c1cc(Cl)ccc1NS(=O)(=O)CC 10.1021/acsmedchemlett.2c00100
CHEMBL5092269 222135 6 None - 0 Human 5.4 pEC50 = 5.4 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL None None None Fc1ccccc1Oc1ncnc2sccc12 10.1021/acs.jmedchem.1c01709
168283988 198026 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 420 7 2 4 3.8 CCS(=O)(=O)Nc1ccc(F)cc1C(=O)Nc1ccccc1OCC(F)(F)F 10.1021/acsmedchemlett.2c00100
CHEMBL5190176 198026 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 420 7 2 4 3.8 CCS(=O)(=O)Nc1ccc(F)cc1C(=O)Nc1ccccc1OCC(F)(F)F 10.1021/acsmedchemlett.2c00100
CHEMBL5078996 221376 16 None - 0 Human 6.3 pEC50 = 6.3 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL None None None Cc1ccccc1Oc1ncnc2sc(C)c(C)c12 10.1021/acs.jmedchem.1c01709
101401182 7494 23 None - 1 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human MrgprX1Agonist activity at human MrgprX1
ChEMBL None None None None 10.1021/acs.jmedchem.9b01003
16158367 7494 23 None - 1 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human MrgprX1Agonist activity at human MrgprX1
ChEMBL None None None None 10.1021/acs.jmedchem.9b01003
4058 7494 23 None - 1 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human MrgprX1Agonist activity at human MrgprX1
ChEMBL None None None None 10.1021/acs.jmedchem.9b01003
CHEMBL3343989 7494 23 None - 1 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human MrgprX1Agonist activity at human MrgprX1
ChEMBL None None None None 10.1021/acs.jmedchem.9b01003
10482 7786 18 None - 3 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 435 6 2 6 4.7 COc1ccccc1S(=O)(=O)Nc1ccc(cc1Oc1ccc2c(c1)ccnc2N)C 10.1021/acs.jmedchem.9b01003
139030531 7786 18 None - 3 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 435 6 2 6 4.7 COc1ccccc1S(=O)(=O)Nc1ccc(cc1Oc1ccc2c(c1)ccnc2N)C 10.1021/acs.jmedchem.9b01003
CHEMBL4460098 7786 18 None - 3 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 435 6 2 6 4.7 COc1ccccc1S(=O)(=O)Nc1ccc(cc1Oc1ccc2c(c1)ccnc2N)C 10.1021/acs.jmedchem.9b01003
101401182 7494 23 None - 1 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2014.09.025
16158367 7494 23 None - 1 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2014.09.025
4058 7494 23 None - 1 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2014.09.025
CHEMBL3343989 7494 23 None - 1 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2014.09.025
122185 121925 22 None - 0 Mouse 6.3 pEC50 = 6.3 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL 320 9 6 4 -1.2 N=C(N)NCCC[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2014.09.025
CHEMBL3343990 121925 22 None - 0 Mouse 6.3 pEC50 = 6.3 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL 320 9 6 4 -1.2 N=C(N)NCCC[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2014.09.025
118717465 121926 0 None - 0 Mouse 6.3 pEC50 = 6.3 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL 332 7 6 4 -1.3 N=C(N)NC[C@@H]1CN[C@H](C(=O)N[C@@H](Cc2ccccc2)C(N)=O)C1 10.1016/j.bmc.2014.09.025
CHEMBL3343991 121926 0 None - 0 Mouse 6.3 pEC50 = 6.3 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL 332 7 6 4 -1.3 N=C(N)NC[C@@H]1CN[C@H](C(=O)N[C@@H](Cc2ccccc2)C(N)=O)C1 10.1016/j.bmc.2014.09.025
118717467 121928 0 None - 0 Rat 4.3 pEC50 = 4.3 Binding
Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL 368 8 6 4 0.1 N=C(N)Nc1ccc(C[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1016/j.bmc.2014.09.025
CHEMBL3343993 121928 0 None - 0 Rat 4.3 pEC50 = 4.3 Binding
Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL 368 8 6 4 0.1 N=C(N)Nc1ccc(C[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1016/j.bmc.2014.09.025
168278287 197904 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 414 7 2 4 3.8 O=C(Nc1ccccc1OCC(F)(F)F)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
CHEMBL5188039 197904 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 414 7 2 4 3.8 O=C(Nc1ccccc1OCC(F)(F)F)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
168286049 198099 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 374 8 2 4 3.6 CCCOc1ccccc1NC(=O)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
CHEMBL5191409 198099 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 374 8 2 4 3.6 CCCOc1ccccc1NC(=O)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
23646462 70263 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 361 8 3 4 4.2 COc1cc(CNc2ccc(C(=N)N)cc2)ccc1OCc1ccccc1 10.1021/acs.jmedchem.9b01003
CHEMBL179938 70263 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 361 8 3 4 4.2 COc1cc(CNc2ccc(C(=N)N)cc2)ccc1OCc1ccccc1 10.1021/acs.jmedchem.9b01003
CHEMBL5093049 222182 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay
ChEMBL None None None Cc1sc2ncnc(Oc3ccccc3C(F)(F)F)c2c1C 10.1021/acs.jmedchem.1c01709
155511165 176336 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 331 7 3 3 4.2 N=C(N)c1ccc(NCc2ccc(OCc3ccccc3)cc2)cc1 10.1021/acs.jmedchem.9b01003
CHEMBL4435637 176336 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 331 7 3 3 4.2 N=C(N)c1ccc(NCc2ccc(OCc3ccccc3)cc2)cc1 10.1021/acs.jmedchem.9b01003
155541652 179843 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 362 8 3 5 3.6 COc1cc(CNc2ccc(C(=N)N)cc2)ccc1OCc1cccnc1 10.1021/acs.jmedchem.9b01003
CHEMBL4519524 179843 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 362 8 3 5 3.6 COc1cc(CNc2ccc(C(=N)N)cc2)ccc1OCc1cccnc1 10.1021/acs.jmedchem.9b01003
168293057 198854 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 394 7 2 4 3.9 CCOc1ccccc1NC(=O)c1cc(Cl)ccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
CHEMBL5202767 198854 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 394 7 2 4 3.9 CCOc1ccccc1NC(=O)c1cc(Cl)ccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
168282623 197704 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 412 7 2 4 4.0 CCOc1ccc(F)cc1NC(=O)c1cc(Cl)ccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
CHEMBL5185447 197704 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 412 7 2 4 4.0 CCOc1ccc(F)cc1NC(=O)c1cc(Cl)ccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
25026048 140718 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 541 13 5 6 4.3 CCCCNC(=O)c1ccc2c(c1)nc(-c1cccc(Oc3ccccc3)c1)n2[C@@H](CCCNC(=N)N)C(N)=O nan
CHEMBL3715864 140718 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 541 13 5 6 4.3 CCCCNC(=O)c1ccc2c(c1)nc(-c1cccc(Oc3ccccc3)c1)n2[C@@H](CCCNC(=N)N)C(N)=O nan
59819658 140766 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 658 11 4 7 5.4 Cc1cccc(N2CCN(C(=O)c3ccc4c(c3)nc(-c3cccc(Oc5ccccc5)c3)n4[C@@H](CCCNC(=N)N)C(N)=O)CC2C)c1 nan
CHEMBL3716029 140766 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 658 11 4 7 5.4 Cc1cccc(N2CCN(C(=O)c3ccc4c(c3)nc(-c3cccc(Oc5ccccc5)c3)n4[C@@H](CCCNC(=N)N)C(N)=O)CC2C)c1 nan
118717468 121929 1 None - 0 Rat 6.2 pEC50 = 6.2 Binding
Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL 368 8 6 4 0.1 N=C(N)Nc1ccc(C[C@@H](N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1016/j.bmc.2014.09.025
CHEMBL3343994 121929 1 None - 0 Rat 6.2 pEC50 = 6.2 Binding
Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL 368 8 6 4 0.1 N=C(N)Nc1ccc(C[C@@H](N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1016/j.bmc.2014.09.025
1486 10096 28 None - 2 Rat 5.2 pEC50 = 5.2 Binding
Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None NC(=N)NCCC[C@@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)NC(=O)C12CC3CC(C2)CC(C1)C3 10.1016/j.bmc.2014.09.025
53320361 10096 28 None - 2 Rat 5.2 pEC50 = 5.2 Binding
Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None NC(=N)NCCC[C@@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)NC(=O)C12CC3CC(C2)CC(C1)C3 10.1016/j.bmc.2014.09.025
CHEMBL1672380 10096 28 None - 2 Rat 5.2 pEC50 = 5.2 Binding
Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL None None None NC(=N)NCCC[C@@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)NC(=O)C12CC3CC(C2)CC(C1)C3 10.1016/j.bmc.2014.09.025
122185 121925 22 None - 0 Rat 5.2 pEC50 = 5.2 Binding
Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL 320 9 6 4 -1.2 N=C(N)NCCC[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2014.09.025
CHEMBL3343990 121925 22 None - 0 Rat 5.2 pEC50 = 5.2 Binding
Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assayAgonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL 320 9 6 4 -1.2 N=C(N)NCCC[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2014.09.025
155542939 179951 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 426 9 3 5 5.0 COc1cc(CNc2ccc(C(=N)N)cc2)ccc1OCc1ccc(-n2cccc2)cc1 10.1021/acs.jmedchem.9b01003
CHEMBL4521959 179951 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 426 9 3 5 5.0 COc1cc(CNc2ccc(C(=N)N)cc2)ccc1OCc1ccc(-n2cccc2)cc1 10.1021/acs.jmedchem.9b01003
168287539 198338 0 None - 1 Human 7.2 pEC50 = 7.2 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 392 7 2 4 3.7 CCOc1ccc(F)cc1NC(=O)c1cc(C)ccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
CHEMBL5194692 198338 0 None - 1 Human 7.2 pEC50 = 7.2 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 392 7 2 4 3.7 CCOc1ccc(F)cc1NC(=O)c1cc(C)ccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
25026047 141031 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 591 12 5 7 5.0 COc1ccc(NC(=O)c2ccc3c(c2)nc(-c2cccc(Oc4ccccc4)c2)n3[C@@H](CCCNC(=N)N)C(N)=O)cc1 nan
CHEMBL3716921 141031 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Activation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assayActivation of human MrgX1 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay
ChEMBL 591 12 5 7 5.0 COc1ccc(NC(=O)c2ccc3c(c2)nc(-c2cccc(Oc4ccccc4)c2)n3[C@@H](CCCNC(=N)N)C(N)=O)cc1 nan
118717464 121924 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL 346 6 5 4 -0.9 N=C(N)N1CCC(C(N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)CC1 10.1016/j.bmc.2014.09.025
CHEMBL3343988 121924 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL 346 6 5 4 -0.9 N=C(N)N1CCC(C(N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)CC1 10.1016/j.bmc.2014.09.025
118717463 121923 0 None - 0 Mouse 5.1 pEC50 = 5.1 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL 318 6 6 4 -1.6 N=C(N)N[C@@H]1CN[C@H](C(=O)N[C@@H](Cc2ccccc2)C(N)=O)C1 10.1016/j.bmc.2014.09.025
CHEMBL3343987 121923 0 None - 0 Mouse 5.1 pEC50 = 5.1 Binding
Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assayAgonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay
ChEMBL 318 6 6 4 -1.6 N=C(N)N[C@@H]1CN[C@H](C(=O)N[C@@H](Cc2ccccc2)C(N)=O)C1 10.1016/j.bmc.2014.09.025
168276174 197145 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 380 7 2 4 3.5 CCOc1ccc(F)cc1NC(=O)c1cc(C)ccc1NS(=O)(=O)CC 10.1021/acsmedchemlett.2c00100
CHEMBL5177145 197145 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 380 7 2 4 3.5 CCOc1ccc(F)cc1NC(=O)c1cc(C)ccc1NS(=O)(=O)CC 10.1021/acsmedchemlett.2c00100
168295597 199016 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 378 7 2 4 3.4 CCOc1ccccc1NC(=O)c1ccc(F)cc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
CHEMBL5205161 199016 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 378 7 2 4 3.4 CCOc1ccccc1NC(=O)c1ccc(F)cc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
168286158 198220 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 374 5 2 5 2.6 O=C(Nc1cccc2c1OCCO2)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
CHEMBL5193017 198220 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 374 5 2 5 2.6 O=C(Nc1cccc2c1OCCO2)c1ccccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
168270533 196676 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 448 7 2 4 4.4 O=C(Nc1ccccc1OCC(F)(F)F)c1cc(Cl)ccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
CHEMBL5169615 196676 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 448 7 2 4 4.4 O=C(Nc1ccccc1OCC(F)(F)F)c1cc(Cl)ccc1NS(=O)(=O)C1CC1 10.1021/acsmedchemlett.2c00100
155518019 177015 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 361 8 3 4 3.6 CCCCS(=O)(=O)Nc1cc(C)ccc1Oc1ccc(C(=N)N)cc1 10.1021/acs.jmedchem.9b01003
CHEMBL4445698 177015 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assayAgonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay
ChEMBL 361 8 3 4 3.6 CCCCS(=O)(=O)Nc1cc(C)ccc1Oc1ccc(C(=N)N)cc1 10.1021/acs.jmedchem.9b01003
168269481 196799 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 366 7 2 4 3.2 CCOc1ccccc1NC(=O)c1cc(F)ccc1NS(=O)(=O)CC 10.1021/acsmedchemlett.2c00100
CHEMBL5171656 196799 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assayPositive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
ChEMBL 366 7 2 4 3.2 CCOc1ccccc1NC(=O)c1cc(F)ccc1NS(=O)(=O)CC 10.1021/acsmedchemlett.2c00100
11539607 143029 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 446 5 1 3 6.2 O=C(Nc1ccccc1Cl)O[C@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3733177 143029 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 446 5 1 3 6.2 O=C(Nc1ccccc1Cl)O[C@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11641227 142569 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 462 5 1 3 6.7 O=C(Nc1cccc2ccccc12)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3730405 142569 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 462 5 1 3 6.7 O=C(Nc1cccc2ccccc12)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
46221498 142262 3 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3728505 142262 3 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11552633 142803 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 379 5 0 1 6.1 C(\Cc1ccccc1)=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3731811 142803 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 379 5 0 1 6.1 C(\Cc1ccccc1)=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11718827 142625 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 425 6 1 3 5.6 COc1ccccc1C(O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3730717 142625 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 425 6 1 3 5.6 COc1ccccc1C(O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11661466 43690 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 408 6 0 3 5.4 N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 nan
CHEMBL145103 43690 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 408 6 0 3 5.4 N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 nan
11503486 142939 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 457 6 1 5 5.4 O=C(Nc1cccc([N+](=O)[O-])c1)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3732603 142939 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 457 6 1 5 5.4 O=C(Nc1cccc([N+](=O)[O-])c1)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
127036914 142807 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 465 5 0 3 6.2 O=C(O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccccc1C(F)(F)F nan
CHEMBL3731844 142807 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 465 5 0 3 6.2 O=C(O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccccc1C(F)(F)F nan
11691090 142172 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 457 6 2 3 5.3 COc1ccccc1NC(=S)N[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3728009 142172 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 457 6 2 3 5.3 COc1ccccc1NC(=S)N[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11539085 121930 16 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 423 6 0 3 5.7 COc1ccccc1C(=O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3343995 121930 16 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 423 6 0 3 5.7 COc1ccccc1C(=O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
54580026 67799 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assayAntagonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL 660 13 1 9 4.4 O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(CCCN1CCOCC1)Cc1c(Cl)cncc1Cl 10.1016/j.bmc.2014.09.025
CHEMBL1762707 67799 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assayAntagonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL 660 13 1 9 4.4 O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(CCCN1CCOCC1)Cc1c(Cl)cncc1Cl 10.1016/j.bmc.2014.09.025
11561403 142600 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 446 5 1 3 6.2 O=C(Nc1ccccc1Cl)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
CHEMBL3730599 142600 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 446 5 1 3 6.2 O=C(Nc1ccccc1Cl)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 nan
11618499 142158 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 413 5 1 2 5.7 OC(/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccc(F)cc1 nan
CHEMBL3727861 142158 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based techniqueBinding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique
ChEMBL 413 5 1 2 5.7 OC(/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccc(F)cc1 nan
11539085 121930 16 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assayAntagonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL 423 6 0 3 5.7 COc1ccccc1C(=O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2014.09.025
CHEMBL3343995 121930 16 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assayAntagonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay
ChEMBL 423 6 0 3 5.7 COc1ccccc1C(=O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2014.09.025
101401182 7494 23 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11850634
16158367 7494 23 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11850634
4058 7494 23 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11850634
CHEMBL3343989 7494 23 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11850634
101401182 7494 23 None - 1 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11850634
16158367 7494 23 None - 1 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11850634
4058 7494 23 None - 1 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11850634
CHEMBL3343989 7494 23 None - 1 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11850634