Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
2906 2355 18 None -15 12 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 436 20 3 5 5.0 CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O 18466763
5395 2355 18 None -15 12 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 436 20 3 5 5.0 CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O 18466763
5497152 2355 18 None -15 12 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 436 20 3 5 5.0 CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O 18466763
CHEMBL1222042 2355 18 None -15 12 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 436 20 3 5 5.0 CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O 18466763
10883396 3649 45 None -45 15 Human 7.3 pEC50 = 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 18466763
5283560 3649 45 None -45 15 Human 7.3 pEC50 = 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 18466763
911 3649 45 None -45 15 Human 7.3 pEC50 = 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 18466763
CHEMBL225155 3649 45 None -45 15 Human 7.3 pEC50 = 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 18466763


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
Sel. page Similar-
ity		 Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Assay
Type		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
78319665 180493 0 None - 0 Mouse 9.0 pEC50 = 9.0 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4753103 180493 0 None - 0 Mouse 9.0 pEC50 = 9.0 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
78319665 180493 0 None - 0 Mouse 9.0 pEC50 = 9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4753103 180493 0 None - 0 Mouse 9.0 pEC50 = 9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
122177528 121190 0 None - 0 Human 8.9 pEC50 = 8.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 563 23 3 8 5.0 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577182 121190 0 None - 0 Human 8.9 pEC50 = 8.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 563 23 3 8 5.0 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177528 121190 0 None - 0 Human 8.9 pEC50 = 8.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 563 23 3 8 5.0 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577182 121190 0 None - 0 Human 8.9 pEC50 = 8.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 563 23 3 8 5.0 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177525 121187 0 None - 0 Human 8.8 pEC50 = 8.8 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 545 23 3 8 5.0 CCCCCCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577179 121187 0 None - 0 Human 8.8 pEC50 = 8.8 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 545 23 3 8 5.0 CCCCCCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177525 121187 0 None - 0 Human 8.8 pEC50 = 8.8 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 545 23 3 8 5.0 CCCCCCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577179 121187 0 None - 0 Human 8.8 pEC50 = 8.8 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 545 23 3 8 5.0 CCCCCCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177517 121179 0 None - 0 Human 8.7 pEC50 = 8.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 561 23 4 9 4.0 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577171 121179 0 None - 0 Human 8.7 pEC50 = 8.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 561 23 4 9 4.0 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177514 121175 0 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 505 19 4 9 2.4 CCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/jm5020082
CHEMBL3577168 121175 0 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 505 19 4 9 2.4 CCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/jm5020082
122177514 121175 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 505 19 4 9 2.4 CCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/jm5020082
CHEMBL3577168 121175 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 505 19 4 9 2.4 CCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/jm5020082
122177504 121166 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 522 24 5 7 4.0 CCCCCCCC/C=C\CCCCCCCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577156 121166 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 522 24 5 7 4.0 CCCCCCCC/C=C\CCCCCCCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177518 121180 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 561 23 4 9 4.0 CCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/jm5020082
CHEMBL3577172 121180 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 561 23 4 9 4.0 CCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/jm5020082
118555095 180700 0 None - 0 Mouse 7.9 pEC50 = 7.9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1CCOC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4755564 180700 0 None - 0 Mouse 7.9 pEC50 = 7.9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1CCOC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
122177518 121180 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 561 23 4 9 4.0 CCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/jm5020082
CHEMBL3577172 121180 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 561 23 4 9 4.0 CCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/jm5020082
118555095 180700 0 None - 0 Mouse 7.9 pEC50 = 7.9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1CCOC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4755564 180700 0 None - 0 Mouse 7.9 pEC50 = 7.9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1CCOC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
122177521 121183 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 617 27 4 9 5.5 CCCCCCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/jm5020082
CHEMBL3577175 121183 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 617 27 4 9 5.5 CCCCCCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/jm5020082
122177513 121174 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 505 19 4 9 2.4 CCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577167 121174 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 505 19 4 9 2.4 CCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177504 121166 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 522 24 5 7 4.0 CCCCCCCC/C=C\CCCCCCCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577156 121166 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 522 24 5 7 4.0 CCCCCCCC/C=C\CCCCCCCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177513 121174 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 505 19 4 9 2.4 CCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577167 121174 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 505 19 4 9 2.4 CCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177521 121183 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 617 27 4 9 5.5 CCCCCCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/jm5020082
CHEMBL3577175 121183 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 617 27 4 9 5.5 CCCCCCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/jm5020082
162645155 179431 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4740368 179431 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
118555093 180626 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1COCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4754776 180626 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1COCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
162645155 179431 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4740368 179431 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
118555093 180626 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1COCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4754776 180626 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1COCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
118584208 179991 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 613 27 3 8 6.7 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](COCc1ccccc1)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4746971 179991 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 613 27 3 8 6.7 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](COCc1ccccc1)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
122177506 121168 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 537 24 3 9 4.6 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)OC 10.1021/jm5020082
CHEMBL3577158 121168 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 537 24 3 9 4.6 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)OC 10.1021/jm5020082
118584208 179991 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 613 27 3 8 6.7 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](COCc1ccccc1)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4746971 179991 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 613 27 3 8 6.7 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](COCc1ccccc1)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
122177493 121153 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 525 24 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577141 121153 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 525 24 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177506 121168 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 537 24 3 9 4.6 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)OC 10.1021/jm5020082
CHEMBL3577158 121168 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 537 24 3 9 4.6 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)OC 10.1021/jm5020082
118555083 182775 0 None - 0 Mouse 6.8 pEC50 = 6.8 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1COCC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4790301 182775 0 None - 0 Mouse 6.8 pEC50 = 6.8 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1COCC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
122177493 121153 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 525 24 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577141 121153 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 525 24 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
118555083 182775 0 None - 0 Mouse 6.8 pEC50 = 6.8 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1COCC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4790301 182775 0 None - 0 Mouse 6.8 pEC50 = 6.8 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1COCC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
118555091 140603 0 None - 0 Mouse 7.8 pEC50 = 7.8 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 599 22 3 9 4.9 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCC=C[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL3813843 140603 0 None - 0 Mouse 7.8 pEC50 = 7.8 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 599 22 3 9 4.9 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCC=C[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
122177502 121164 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 507 24 3 7 5.5 CCCCCC/C=C\CCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577154 121164 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 507 24 3 7 5.5 CCCCCC/C=C\CCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
162648728 179880 0 None - 0 Mouse 6.8 pEC50 = 6.8 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 573 16 3 9 4.5 C[C@H](COP(=O)(O)OC[C@H](N)C(=O)O)OC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1 10.1021/acs.jmedchem.0c01126
CHEMBL4745697 179880 0 None - 0 Mouse 6.8 pEC50 = 6.8 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 573 16 3 9 4.5 C[C@H](COP(=O)(O)OC[C@H](N)C(=O)O)OC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1 10.1021/acs.jmedchem.0c01126
118555091 140603 0 None - 0 Mouse 7.8 pEC50 = 7.8 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 599 22 3 9 4.9 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCC=C[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL3813843 140603 0 None - 0 Mouse 7.8 pEC50 = 7.8 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 599 22 3 9 4.9 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCC=C[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
122177502 121164 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 507 24 3 7 5.5 CCCCCC/C=C\CCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577154 121164 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 507 24 3 7 5.5 CCCCCC/C=C\CCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
162648728 179880 0 None - 0 Mouse 6.8 pEC50 = 6.8 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 573 16 3 9 4.5 C[C@H](COP(=O)(O)OC[C@H](N)C(=O)O)OC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1 10.1021/acs.jmedchem.0c01126
CHEMBL4745697 179880 0 None - 0 Mouse 6.8 pEC50 = 6.8 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 573 16 3 9 4.5 C[C@H](COP(=O)(O)OC[C@H](N)C(=O)O)OC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1 10.1021/acs.jmedchem.0c01126
9547099 60286 2 None - 0 Mouse 7.7 pEC50 = 7.7 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 523 24 4 8 4.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL1742484 60286 2 None - 0 Mouse 7.7 pEC50 = 7.7 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 523 24 4 8 4.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
71495077 121150 0 None - 0 Mouse 7.7 pEC50 = 7.7 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 24 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL3577137 121150 0 None - 0 Mouse 7.7 pEC50 = 7.7 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 24 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
122177517 121179 0 None - 0 Human 8.7 pEC50 = 8.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 561 23 4 9 4.0 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577171 121179 0 None - 0 Human 8.7 pEC50 = 8.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 561 23 4 9 4.0 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177520 121182 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 617 27 4 9 5.5 CCCCCCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577174 121182 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 617 27 4 9 5.5 CCCCCCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177520 121182 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 617 27 4 9 5.5 CCCCCCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577174 121182 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 617 27 4 9 5.5 CCCCCCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
9547099 60286 2 None - 0 Mouse 7.7 pEC50 = 7.7 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 523 24 4 8 4.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL1742484 60286 2 None - 0 Mouse 7.7 pEC50 = 7.7 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 523 24 4 8 4.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
71495077 121150 0 None - 0 Mouse 7.7 pEC50 = 7.7 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 24 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL3577137 121150 0 None - 0 Mouse 7.7 pEC50 = 7.7 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 24 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
122177509 121171 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 509 22 4 8 4.1 CCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577163 121171 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 509 22 4 8 4.1 CCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O 10.1021/jm5020082
122177498 121160 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 481 23 3 7 4.9 CCCCCCCCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577150 121160 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 481 23 3 7 4.9 CCCCCCCCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177498 121160 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 481 23 3 7 4.9 CCCCCCCCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577150 121160 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 481 23 3 7 4.9 CCCCCCCCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177510 121172 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 511 23 4 8 4.3 CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577164 121172 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 511 23 4 8 4.3 CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O 10.1021/jm5020082
122177509 121171 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 509 22 4 8 4.1 CCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577163 121171 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 509 22 4 8 4.1 CCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O 10.1021/jm5020082
122177510 121172 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 511 23 4 8 4.3 CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577164 121172 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 511 23 4 8 4.3 CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O 10.1021/jm5020082
101780959 121169 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 537 24 4 8 4.9 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@H](C)[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577161 121169 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 537 24 4 8 4.9 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@H](C)[C@H](N)C(=O)O 10.1021/jm5020082
101780959 121169 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 537 24 4 8 4.9 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@H](C)[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577161 121169 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 537 24 4 8 4.9 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@H](C)[C@H](N)C(=O)O 10.1021/jm5020082
162655340 180760 0 None - 0 Mouse 5.6 pEC50 = 5.6 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 559 16 3 9 4.1 N[C@@H](COP(=O)(O)OCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4756147 180760 0 None - 0 Mouse 5.6 pEC50 = 5.6 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 559 16 3 9 4.1 N[C@@H](COP(=O)(O)OCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)C(=O)O 10.1021/acs.jmedchem.0c01126
162655340 180760 0 None - 0 Mouse 5.6 pEC50 = 5.6 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 559 16 3 9 4.1 N[C@@H](COP(=O)(O)OCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4756147 180760 0 None - 0 Mouse 5.6 pEC50 = 5.6 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 559 16 3 9 4.1 N[C@@H](COP(=O)(O)OCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)C(=O)O 10.1021/acs.jmedchem.0c01126
162674211 183132 0 None - 0 Mouse 6.6 pEC50 = 6.6 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 535 26 3 7 6.3 CCCCCCCC/C=C\CCCCCCCC(=O)OCCCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4795101 183132 0 None - 0 Mouse 6.6 pEC50 = 6.6 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 535 26 3 7 6.3 CCCCCCCC/C=C\CCCCCCCC(=O)OCCCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
9547099 60286 2 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 523 24 4 8 4.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL1742484 60286 2 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 523 24 4 8 4.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
162674211 183132 0 None - 0 Mouse 6.6 pEC50 = 6.6 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 535 26 3 7 6.3 CCCCCCCC/C=C\CCCCCCCC(=O)OCCCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4795101 183132 0 None - 0 Mouse 6.6 pEC50 = 6.6 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 535 26 3 7 6.3 CCCCCCCC/C=C\CCCCCCCC(=O)OCCCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
78319598 180088 0 None - 0 Mouse 6.6 pEC50 = 6.6 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 23 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](C)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4748142 180088 0 None - 0 Mouse 6.6 pEC50 = 6.6 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 23 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](C)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
71495077 121150 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 507 24 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577137 121150 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 507 24 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
9547099 60286 2 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 523 24 4 8 4.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL1742484 60286 2 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 523 24 4 8 4.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
71495077 121150 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 507 24 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577137 121150 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 507 24 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
9547100 121156 3 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 497 23 4 8 3.9 CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577145 121156 3 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 497 23 4 8 3.9 CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
78319598 180088 0 None - 0 Mouse 6.6 pEC50 = 6.6 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 23 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](C)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4748142 180088 0 None - 0 Mouse 6.6 pEC50 = 6.6 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 23 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](C)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
9547100 121156 3 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 497 23 4 8 3.9 CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577145 121156 3 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 497 23 4 8 3.9 CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
78319667 181031 0 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1COCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4759297 181031 0 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1COCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
78319667 181031 0 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1COCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4759297 181031 0 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1COCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
9547099 60286 2 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 523 24 4 8 4.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL1742484 60286 2 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 523 24 4 8 4.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
9547099 60286 2 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 523 24 4 8 4.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL1742484 60286 2 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 523 24 4 8 4.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
145948821 167499 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 601 22 3 9 5.2 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1CCCO[C@@H]1COP(=O)(O)OC[C@@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL4299634 167499 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 601 22 3 9 5.2 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1CCCO[C@@H]1COP(=O)(O)OC[C@@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
76900162 181085 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 573 16 3 9 4.5 C[C@H](COC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4759998 181085 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 573 16 3 9 4.5 C[C@H](COC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
145948821 167499 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 601 22 3 9 5.2 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1CCCO[C@@H]1COP(=O)(O)OC[C@@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL4299634 167499 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 601 22 3 9 5.2 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1CCCO[C@@H]1COP(=O)(O)OC[C@@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
76900162 181085 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 573 16 3 9 4.5 C[C@H](COC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4759998 181085 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 573 16 3 9 4.5 C[C@H](COC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
122177516 121178 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 533 21 4 9 3.2 CCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577170 121178 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 533 21 4 9 3.2 CCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177516 121178 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 533 21 4 9 3.2 CCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577170 121178 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 533 21 4 9 3.2 CCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177589 121192 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 581 23 3 8 5.3 CCCCCCCCCCCOc1ccccc1CCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577262 121192 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 581 23 3 8 5.3 CCCCCCCCCCCOc1ccccc1CCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177589 121192 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 581 23 3 8 5.3 CCCCCCCCCCCOc1ccccc1CCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577262 121192 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 581 23 3 8 5.3 CCCCCCCCCCCOc1ccccc1CCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177524 121186 0 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 517 21 3 8 4.2 CCCCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577178 121186 0 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 517 21 3 8 4.2 CCCCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177524 121186 0 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 517 21 3 8 4.2 CCCCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577178 121186 0 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 517 21 3 8 4.2 CCCCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177526 121188 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 545 23 3 8 5.0 CCCCCCCCCCCOc1cccc(CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/jm5020082
CHEMBL3577180 121188 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 545 23 3 8 5.0 CCCCCCCCCCCOc1cccc(CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/jm5020082
78319746 140617 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 627 16 3 10 4.4 N[C@@H](COP(=O)(O)O[C@H]1C=CCO[C@@H]1COC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL3814147 140617 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 627 16 3 10 4.4 N[C@@H](COP(=O)(O)O[C@H]1C=CCO[C@@H]1COC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)C(=O)O 10.1021/acs.jmedchem.5b01925
122177526 121188 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 545 23 3 8 5.0 CCCCCCCCCCCOc1cccc(CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/jm5020082
CHEMBL3577180 121188 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 545 23 3 8 5.0 CCCCCCCCCCCOc1cccc(CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/jm5020082
122177505 121167 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 493 25 3 6 6.0 CCCCCCCC/C=C\CCCCCCCCOCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577157 121167 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 493 25 3 6 6.0 CCCCCCCC/C=C\CCCCCCCCOCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
78319746 140617 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 627 16 3 10 4.4 N[C@@H](COP(=O)(O)O[C@H]1C=CCO[C@@H]1COC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL3814147 140617 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 627 16 3 10 4.4 N[C@@H](COP(=O)(O)O[C@H]1C=CCO[C@@H]1COC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)C(=O)O 10.1021/acs.jmedchem.5b01925
122177505 121167 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 493 25 3 6 6.0 CCCCCCCC/C=C\CCCCCCCCOCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577157 121167 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 493 25 3 6 6.0 CCCCCCCC/C=C\CCCCCCCCOCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
78319597 181465 0 None - 0 Mouse 7.4 pEC50 = 7.4 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 23 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](C)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4764512 181465 0 None - 0 Mouse 7.4 pEC50 = 7.4 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 23 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](C)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
78319597 181465 0 None - 0 Mouse 7.4 pEC50 = 7.4 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 23 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](C)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4764512 181465 0 None - 0 Mouse 7.4 pEC50 = 7.4 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 23 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](C)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
122177490 121151 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 523 24 4 8 4.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577138 121151 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 523 24 4 8 4.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
162677378 183542 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 23 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)O[C@@H](C)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4800110 183542 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 23 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)O[C@@H](C)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
122177490 121151 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 523 24 4 8 4.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577138 121151 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 523 24 4 8 4.5 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
162677378 183542 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 23 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)O[C@@H](C)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4800110 183542 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 23 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)O[C@@H](C)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
122177501 121163 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 507 24 3 7 5.5 CCCCCCCC/C=C/CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577153 121163 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 507 24 3 7 5.5 CCCCCCCC/C=C/CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177501 121163 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 507 24 3 7 5.5 CCCCCCCC/C=C/CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577153 121163 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 507 24 3 7 5.5 CCCCCCCC/C=C/CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
78319710 140595 0 None - 0 Mouse 7.4 pEC50 = 7.4 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 599 22 3 9 4.9 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCC=C[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL3813751 140595 0 None - 0 Mouse 7.4 pEC50 = 7.4 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 599 22 3 9 4.9 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCC=C[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
162651157 180307 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4751008 180307 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
162666591 182347 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 561 26 3 8 5.1 C#CCOC[C@H](COC(=O)CCCCCCC/C=C\CCCCCCCC)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4784581 182347 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 561 26 3 8 5.1 C#CCOC[C@H](COC(=O)CCCCCCC/C=C\CCCCCCCC)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
78319710 140595 0 None - 0 Mouse 7.4 pEC50 = 7.4 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 599 22 3 9 4.9 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCC=C[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL3813751 140595 0 None - 0 Mouse 7.4 pEC50 = 7.4 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 599 22 3 9 4.9 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCC=C[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
162651157 180307 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4751008 180307 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
162666591 182347 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 561 26 3 8 5.1 C#CCOC[C@H](COC(=O)CCCCCCC/C=C\CCCCCCCC)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4784581 182347 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 561 26 3 8 5.1 C#CCOC[C@H](COC(=O)CCCCCCC/C=C\CCCCCCCC)OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
122177499 121161 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 453 21 3 7 4.2 CCCCCCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577151 121161 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 453 21 3 7 4.2 CCCCCCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
127051792 140676 0 None - 0 Mouse 7.4 pEC50 = 7.4 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 593 22 3 8 6.2 CCCCCCCCCCCOc1ccccc1CCC(=O)OCc1ccccc1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL3815090 140676 0 None - 0 Mouse 7.4 pEC50 = 7.4 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 593 22 3 8 6.2 CCCCCCCCCCCOc1ccccc1CCC(=O)OCc1ccccc1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
122177503 121165 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 509 25 4 7 4.9 CCCCCCCC/C=C\CCCCCCCCOC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577155 121165 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 509 25 4 7 4.9 CCCCCCCC/C=C\CCCCCCCCOC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177499 121161 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 453 21 3 7 4.2 CCCCCCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577151 121161 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 453 21 3 7 4.2 CCCCCCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
127051792 140676 0 None - 0 Mouse 7.4 pEC50 = 7.4 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 593 22 3 8 6.2 CCCCCCCCCCCOc1ccccc1CCC(=O)OCc1ccccc1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL3815090 140676 0 None - 0 Mouse 7.4 pEC50 = 7.4 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 593 22 3 8 6.2 CCCCCCCCCCCOc1ccccc1CCC(=O)OCc1ccccc1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
145948884 167500 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 563 23 3 8 5.7 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H]1OCCC[C@H]1OP(=O)(O)OC[C@@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL4299658 167500 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 563 23 3 8 5.7 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H]1OCCC[C@H]1OP(=O)(O)OC[C@@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
145948920 167501 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 561 23 3 8 5.4 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H]1OCC=C[C@H]1OP(=O)(O)OC[C@@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL4299669 167501 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 561 23 3 8 5.4 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H]1OCC=C[C@H]1OP(=O)(O)OC[C@@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
122177503 121165 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 509 25 4 7 4.9 CCCCCCCC/C=C\CCCCCCCCOC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577155 121165 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 509 25 4 7 4.9 CCCCCCCC/C=C\CCCCCCCCOC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177515 121176 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 505 19 4 9 2.4 CCCCCCCOc1ccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)cc1 10.1021/jm5020082
CHEMBL3577169 121176 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 505 19 4 9 2.4 CCCCCCCOc1ccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)cc1 10.1021/jm5020082
145948884 167500 0 None - 0 Mouse 6.3 pEC50 = 6.3 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 563 23 3 8 5.7 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H]1OCCC[C@H]1OP(=O)(O)OC[C@@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL4299658 167500 0 None - 0 Mouse 6.3 pEC50 = 6.3 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 563 23 3 8 5.7 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H]1OCCC[C@H]1OP(=O)(O)OC[C@@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
145948920 167501 0 None - 0 Mouse 6.3 pEC50 = 6.3 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 561 23 3 8 5.4 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H]1OCC=C[C@H]1OP(=O)(O)OC[C@@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL4299669 167501 0 None - 0 Mouse 6.3 pEC50 = 6.3 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 561 23 3 8 5.4 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H]1OCC=C[C@H]1OP(=O)(O)OC[C@@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
122177515 121176 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 505 19 4 9 2.4 CCCCCCCOc1ccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)cc1 10.1021/jm5020082
CHEMBL3577169 121176 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 505 19 4 9 2.4 CCCCCCCOc1ccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)cc1 10.1021/jm5020082
78319747 140655 0 None - 0 Mouse 6.3 pEC50 = 6.3 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 601 22 3 9 5.2 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL3814763 140655 0 None - 0 Mouse 6.3 pEC50 = 6.3 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 601 22 3 9 5.2 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
78319747 140655 0 None - 0 Mouse 6.3 pEC50 = 6.3 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 601 22 3 9 5.2 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL3814763 140655 0 None - 0 Mouse 6.3 pEC50 = 6.3 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 601 22 3 9 5.2 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
162648818 179821 0 None - 0 Mouse 8.2 pEC50 = 8.2 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 531 22 3 8 4.6 CCCCCCCCCCCOc1ccccc1CCC(=O)OCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4745025 179821 0 None - 0 Mouse 8.2 pEC50 = 8.2 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 531 22 3 8 4.6 CCCCCCCCCCCOc1ccccc1CCC(=O)OCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
162648818 179821 0 None - 0 Mouse 8.2 pEC50 = 8.2 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 531 22 3 8 4.6 CCCCCCCCCCCOc1ccccc1CCC(=O)OCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4745025 179821 0 None - 0 Mouse 8.2 pEC50 = 8.2 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 531 22 3 8 4.6 CCCCCCCCCCCOc1ccccc1CCC(=O)OCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
162646889 179560 0 None - 0 Mouse 7.3 pEC50 = 7.3 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 521 25 3 7 5.9 CCCCCCCC/C=C\CCCCCCCC(=O)OCCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4741744 179560 0 None - 0 Mouse 7.3 pEC50 = 7.3 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 521 25 3 7 5.9 CCCCCCCC/C=C\CCCCCCCC(=O)OCCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
122177500 121162 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 425 19 3 7 3.4 CCCCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577152 121162 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 425 19 3 7 3.4 CCCCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177500 121162 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 425 19 3 7 3.4 CCCCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577152 121162 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 425 19 3 7 3.4 CCCCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177522 121184 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 617 27 4 9 5.5 CCCCCCCCCCCCCCCOc1ccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)cc1 10.1021/jm5020082
CHEMBL3577176 121184 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 617 27 4 9 5.5 CCCCCCCCCCCCCCCOc1ccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)cc1 10.1021/jm5020082
162646889 179560 0 None - 0 Mouse 7.3 pEC50 = 7.3 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 521 25 3 7 5.9 CCCCCCCC/C=C\CCCCCCCC(=O)OCCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4741744 179560 0 None - 0 Mouse 7.3 pEC50 = 7.3 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 521 25 3 7 5.9 CCCCCCCC/C=C\CCCCCCCC(=O)OCCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
122177522 121184 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 617 27 4 9 5.5 CCCCCCCCCCCCCCCOc1ccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)cc1 10.1021/jm5020082
CHEMBL3577176 121184 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 617 27 4 9 5.5 CCCCCCCCCCCCCCCOc1ccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)cc1 10.1021/jm5020082
122177527 121189 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 545 23 3 8 5.0 CCCCCCCCCCCOc1ccc(CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)cc1 10.1021/jm5020082
CHEMBL3577181 121189 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 545 23 3 8 5.0 CCCCCCCCCCCOc1ccc(CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)cc1 10.1021/jm5020082
122177590 121193 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 575 23 4 9 4.4 CCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O)c1 10.1021/jm5020082
CHEMBL3577263 121193 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 575 23 4 9 4.4 CCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O)c1 10.1021/jm5020082
122177590 121193 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 575 23 4 9 4.4 CCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O)c1 10.1021/jm5020082
CHEMBL3577263 121193 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 575 23 4 9 4.4 CCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O)c1 10.1021/jm5020082
122177527 121189 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 545 23 3 8 5.0 CCCCCCCCCCCOc1ccc(CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)cc1 10.1021/jm5020082
CHEMBL3577181 121189 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 545 23 3 8 5.0 CCCCCCCCCCCOc1ccc(CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)cc1 10.1021/jm5020082
122177497 121159 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 479 22 3 7 4.7 CCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577149 121159 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 479 22 3 7 4.7 CCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177492 121152 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 535 24 3 7 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)OCC(C)(C)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577140 121152 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 535 24 3 7 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)OCC(C)(C)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177497 121159 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 479 22 3 7 4.7 CCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577149 121159 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 479 22 3 7 4.7 CCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177492 121152 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 535 24 3 7 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)OCC(C)(C)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577140 121152 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 535 24 3 7 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)OCC(C)(C)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
127051793 140635 0 None - 0 Mouse 8.2 pEC50 = 8.2 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 593 22 3 8 6.2 CCCCCCCCCCCOc1ccccc1CCC(=O)OCc1cccc(OP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/acs.jmedchem.5b01925
CHEMBL3814492 140635 0 None - 0 Mouse 8.2 pEC50 = 8.2 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 593 22 3 8 6.2 CCCCCCCCCCCOc1ccccc1CCC(=O)OCc1cccc(OP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/acs.jmedchem.5b01925
127051793 140635 0 None - 0 Mouse 8.2 pEC50 = 8.2 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 593 22 3 8 6.2 CCCCCCCCCCCOc1ccccc1CCC(=O)OCc1cccc(OP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/acs.jmedchem.5b01925
CHEMBL3814492 140635 0 None - 0 Mouse 8.2 pEC50 = 8.2 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 593 22 3 8 6.2 CCCCCCCCCCCOc1ccccc1CCC(=O)OCc1cccc(OP(=O)(O)OC[C@H](N)C(=O)O)c1 10.1021/acs.jmedchem.5b01925
118555087 140612 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 601 22 3 9 5.2 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCCC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL3814009 140612 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 601 22 3 9 5.2 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCCC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
118555087 140612 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 601 22 3 9 5.2 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCCC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
CHEMBL3814009 140612 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL 601 22 3 9 5.2 CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCCC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.5b01925
122177495 121154 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 543 24 3 7 5.7 CCCCCCCC/C=C\CCCCCCCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577143 121154 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 543 24 3 7 5.7 CCCCCCCC/C=C\CCCCCCCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177495 121154 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 543 24 3 7 5.7 CCCCCCCC/C=C\CCCCCCCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577143 121154 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 543 24 3 7 5.7 CCCCCCCC/C=C\CCCCCCCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
162663009 181888 0 None - 0 Mouse 7.2 pEC50 = 7.2 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 493 23 3 7 5.1 CCCCCCCC/C=C\CCCCCCCC(=O)OCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4779063 181888 0 None - 0 Mouse 7.2 pEC50 = 7.2 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 493 23 3 7 5.1 CCCCCCCC/C=C\CCCCCCCC(=O)OCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
162663009 181888 0 None - 0 Mouse 7.2 pEC50 = 7.2 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 493 23 3 7 5.1 CCCCCCCC/C=C\CCCCCCCC(=O)OCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4779063 181888 0 None - 0 Mouse 7.2 pEC50 = 7.2 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 493 23 3 7 5.1 CCCCCCCC/C=C\CCCCCCCC(=O)OCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
162665010 182122 0 None - 0 Mouse 7.2 pEC50 = 7.2 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 537 25 3 8 5.1 CCCCCCCC/C=C\CCCCCCCC(=O)O[C@H](COC)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4782077 182122 0 None - 0 Mouse 7.2 pEC50 = 7.2 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 537 25 3 8 5.1 CCCCCCCC/C=C\CCCCCCCC(=O)O[C@H](COC)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
162665010 182122 0 None - 0 Mouse 7.2 pEC50 = 7.2 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 537 25 3 8 5.1 CCCCCCCC/C=C\CCCCCCCC(=O)O[C@H](COC)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4782077 182122 0 None - 0 Mouse 7.2 pEC50 = 7.2 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 537 25 3 8 5.1 CCCCCCCC/C=C\CCCCCCCC(=O)O[C@H](COC)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
122177511 121173 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 483 21 4 8 3.5 CCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577165 121173 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 483 21 4 8 3.5 CCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O 10.1021/jm5020082
122177511 121173 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 483 21 4 8 3.5 CCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577165 121173 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 483 21 4 8 3.5 CCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O 10.1021/jm5020082
52926277 121157 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 469 21 4 8 3.1 CCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577146 121157 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 469 21 4 8 3.1 CCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
52926277 121157 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 469 21 4 8 3.1 CCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577146 121157 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 469 21 4 8 3.1 CCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
162677130 183556 0 None - 0 Mouse 7.1 pEC50 = 7.1 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 23 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)O[C@H](C)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4800263 183556 0 None - 0 Mouse 7.1 pEC50 = 7.1 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 23 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)O[C@H](C)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
162677130 183556 0 None - 0 Mouse 7.1 pEC50 = 7.1 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 23 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)O[C@H](C)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4800263 183556 0 None - 0 Mouse 7.1 pEC50 = 7.1 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 507 23 3 7 5.5 CCCCCCCC/C=C\CCCCCCCC(=O)O[C@H](C)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
122177519 121181 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 561 23 4 9 4.0 CCCCCCCCCCCOc1ccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)cc1 10.1021/jm5020082
CHEMBL3577173 121181 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 561 23 4 9 4.0 CCCCCCCCCCCOc1ccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)cc1 10.1021/jm5020082
122177519 121181 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 561 23 4 9 4.0 CCCCCCCCCCCOc1ccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)cc1 10.1021/jm5020082
CHEMBL3577173 121181 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 561 23 4 9 4.0 CCCCCCCCCCCOc1ccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)cc1 10.1021/jm5020082
118555084 183223 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1COCC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4796110 183223 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1COCC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
118555084 183223 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1COCC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
CHEMBL4796110 183223 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
ChEMBL 587 21 3 9 4.8 CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1COCC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O 10.1021/acs.jmedchem.0c01126
52926278 121155 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 495 22 4 8 3.7 CCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577144 121155 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 495 22 4 8 3.7 CCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177523 121185 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 489 19 3 8 3.4 CCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577177 121185 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 489 19 3 8 3.4 CCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
52926278 121155 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 495 22 4 8 3.7 CCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577144 121155 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 495 22 4 8 3.7 CCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
122177523 121185 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 489 19 3 8 3.4 CCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577177 121185 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 489 19 3 8 3.4 CCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
44475675 197120 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 509 25 3 7 5.7 CCCCCCCCCCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL567724 197120 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 509 25 3 7 5.7 CCCCCCCCCCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
44475675 197120 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 509 25 3 7 5.7 CCCCCCCCCCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL567724 197120 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 509 25 3 7 5.7 CCCCCCCCCCCCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
52926276 121158 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 441 19 4 8 2.4 CCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577147 121158 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 441 19 4 8 2.4 CCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
52926276 121158 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 441 19 4 8 2.4 CCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082
CHEMBL3577147 121158 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay
ChEMBL 441 19 4 8 2.4 CCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O 10.1021/jm5020082