Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 102331684 | 115317 | None | 0 | Mouse | Functional | pEC50 | = | 4.1 | 4.1 | - | 1 | Agonist activity at mouse GPRC6A expressed in human tsA201 cells coexpressing GalphaqG66D after 30 mins by inositol phosphate turnover assayAgonist activity at mouse GPRC6A expressed in human tsA201 cells coexpressing GalphaqG66D after 30 mins by inositol phosphate turnover assay |
ChEMBL | 186 | 4 | 5 | 3 | -1.3 | N=C(N)NCC[C@H]1C[C@@]1(N)C(=O)O | 10.1039/C1MD00186H | ||
| CHEMBL3347673 | 115317 | None | 0 | Mouse | Functional | pEC50 | = | 4.1 | 4.1 | - | 1 | Agonist activity at mouse GPRC6A expressed in human tsA201 cells coexpressing GalphaqG66D after 30 mins by inositol phosphate turnover assayAgonist activity at mouse GPRC6A expressed in human tsA201 cells coexpressing GalphaqG66D after 30 mins by inositol phosphate turnover assay |
ChEMBL | 186 | 4 | 5 | 3 | -1.3 | N=C(N)NCC[C@H]1C[C@@]1(N)C(=O)O | 10.1039/C1MD00186H | ||
| 8693156 | 124175 | None | 0 | Mouse | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 409 | 6 | 1 | 4 | 2.9 | CN(CC(=O)c1c(-c2ccc(F)cc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
| CHEMBL3633655 | 124175 | None | 0 | Mouse | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 409 | 6 | 1 | 4 | 2.9 | CN(CC(=O)c1c(-c2ccc(F)cc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
| 8693156 | 124175 | None | 0 | Mouse | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 409 | 6 | 1 | 4 | 2.9 | CN(CC(=O)c1c(-c2ccc(F)cc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
| CHEMBL3633655 | 124175 | None | 0 | Mouse | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 409 | 6 | 1 | 4 | 2.9 | CN(CC(=O)c1c(-c2ccc(F)cc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
| 9044803 | 124172 | None | 12 | Mouse | Functional | pIC50 | = | 4.7 | 4.7 | 1 | 2 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 391 | 6 | 1 | 4 | 2.8 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
| CHEMBL3633650 | 124172 | None | 12 | Mouse | Functional | pIC50 | = | 4.7 | 4.7 | 1 | 2 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 391 | 6 | 1 | 4 | 2.8 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
| 9044803 | 124172 | None | 12 | Mouse | Functional | pIC50 | = | 4.7 | 4.7 | 1 | 2 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 391 | 6 | 1 | 4 | 2.8 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
| CHEMBL3633650 | 124172 | None | 12 | Mouse | Functional | pIC50 | = | 4.7 | 4.7 | 1 | 2 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 391 | 6 | 1 | 4 | 2.8 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
| 122195442 | 124173 | None | 0 | Mouse | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 409 | 6 | 1 | 4 | 2.9 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccc(F)cc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
| CHEMBL3633651 | 124173 | None | 0 | Mouse | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 409 | 6 | 1 | 4 | 2.9 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccc(F)cc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
| 122195442 | 124173 | None | 0 | Mouse | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 409 | 6 | 1 | 4 | 2.9 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccc(F)cc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
| CHEMBL3633651 | 124173 | None | 0 | Mouse | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 409 | 6 | 1 | 4 | 2.9 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccc(F)cc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
| 122195453 | 124177 | None | 0 | Mouse | Functional | pIC50 | = | 5.3 | 5.3 | 2 | 2 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 431 | 5 | 1 | 4 | 3.6 | O=C(CN1CCCC(C(=O)N2CCOCC2)C1)c1c(-c2ccccc2)[nH]c2ccccc12 | 10.1021/acs.jmedchem.5b01254 | ||
| CHEMBL3633663 | 124177 | None | 0 | Mouse | Functional | pIC50 | = | 5.3 | 5.3 | 2 | 2 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 431 | 5 | 1 | 4 | 3.6 | O=C(CN1CCCC(C(=O)N2CCOCC2)C1)c1c(-c2ccccc2)[nH]c2ccccc12 | 10.1021/acs.jmedchem.5b01254 | ||
| 122195453 | 124177 | None | 0 | Mouse | Functional | pIC50 | = | 5.3 | 5.3 | 2 | 2 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 431 | 5 | 1 | 4 | 3.6 | O=C(CN1CCCC(C(=O)N2CCOCC2)C1)c1c(-c2ccccc2)[nH]c2ccccc12 | 10.1021/acs.jmedchem.5b01254 | ||
| CHEMBL3633663 | 124177 | None | 0 | Mouse | Functional | pIC50 | = | 5.3 | 5.3 | 2 | 2 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 431 | 5 | 1 | 4 | 3.6 | O=C(CN1CCCC(C(=O)N2CCOCC2)C1)c1c(-c2ccccc2)[nH]c2ccccc12 | 10.1021/acs.jmedchem.5b01254 | ||
| 17521846 | 124178 | None | 4 | Mouse | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 375 | 6 | 1 | 3 | 3.6 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCCC1 | 10.1021/acs.jmedchem.5b01254 | ||
| CHEMBL3633664 | 124178 | None | 4 | Mouse | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 375 | 6 | 1 | 3 | 3.6 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCCC1 | 10.1021/acs.jmedchem.5b01254 | ||
| 17521846 | 124178 | None | 4 | Mouse | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 375 | 6 | 1 | 3 | 3.6 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCCC1 | 10.1021/acs.jmedchem.5b01254 | ||
| CHEMBL3633664 | 124178 | None | 4 | Mouse | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 375 | 6 | 1 | 3 | 3.6 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCCC1 | 10.1021/acs.jmedchem.5b01254 | ||
| 122195454 | 124179 | None | 0 | Mouse | Functional | pIC50 | = | 5.2 | 5.2 | 8 | 2 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 377 | 7 | 1 | 4 | 3.3 | CN(CCN1CCOCC1)CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12 | 10.1021/acs.jmedchem.5b01254 | ||
| CHEMBL3633665 | 124179 | None | 0 | Mouse | Functional | pIC50 | = | 5.2 | 5.2 | 8 | 2 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 377 | 7 | 1 | 4 | 3.3 | CN(CCN1CCOCC1)CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12 | 10.1021/acs.jmedchem.5b01254 | ||
| 122195454 | 124179 | None | 0 | Mouse | Functional | pIC50 | = | 5.2 | 5.2 | 8 | 2 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 377 | 7 | 1 | 4 | 3.3 | CN(CCN1CCOCC1)CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12 | 10.1021/acs.jmedchem.5b01254 | ||
| CHEMBL3633665 | 124179 | None | 0 | Mouse | Functional | pIC50 | = | 5.2 | 5.2 | 8 | 2 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 377 | 7 | 1 | 4 | 3.3 | CN(CCN1CCOCC1)CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12 | 10.1021/acs.jmedchem.5b01254 | ||
| 122195445 | 124174 | None | 0 | Mouse | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 421 | 7 | 1 | 5 | 2.8 | COc1ccc2[nH]c(-c3ccccc3)c(C(=O)CN(C)CC(=O)N3CCOCC3)c2c1 | 10.1021/acs.jmedchem.5b01254 | ||
| CHEMBL3633654 | 124174 | None | 0 | Mouse | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 421 | 7 | 1 | 5 | 2.8 | COc1ccc2[nH]c(-c3ccccc3)c(C(=O)CN(C)CC(=O)N3CCOCC3)c2c1 | 10.1021/acs.jmedchem.5b01254 | ||
| 122195445 | 124174 | None | 0 | Mouse | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 421 | 7 | 1 | 5 | 2.8 | COc1ccc2[nH]c(-c3ccccc3)c(C(=O)CN(C)CC(=O)N3CCOCC3)c2c1 | 10.1021/acs.jmedchem.5b01254 | ||
| CHEMBL3633654 | 124174 | None | 0 | Mouse | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 421 | 7 | 1 | 5 | 2.8 | COc1ccc2[nH]c(-c3ccccc3)c(C(=O)CN(C)CC(=O)N3CCOCC3)c2c1 | 10.1021/acs.jmedchem.5b01254 | ||
| 122195446 | 124176 | None | 0 | Mouse | Functional | pIC50 | = | 5.0 | 5.0 | 1 | 5 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 421 | 7 | 1 | 5 | 2.8 | COc1ccc(-c2[nH]c3ccccc3c2C(=O)CN(C)CC(=O)N2CCOCC2)cc1 | 10.1021/acs.jmedchem.5b01254 | ||
| CHEMBL3633656 | 124176 | None | 0 | Mouse | Functional | pIC50 | = | 5.0 | 5.0 | 1 | 5 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 421 | 7 | 1 | 5 | 2.8 | COc1ccc(-c2[nH]c3ccccc3c2C(=O)CN(C)CC(=O)N2CCOCC2)cc1 | 10.1021/acs.jmedchem.5b01254 | ||
| 122195446 | 124176 | None | 0 | Mouse | Functional | pIC50 | = | 5.0 | 5.0 | 1 | 5 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 421 | 7 | 1 | 5 | 2.8 | COc1ccc(-c2[nH]c3ccccc3c2C(=O)CN(C)CC(=O)N2CCOCC2)cc1 | 10.1021/acs.jmedchem.5b01254 | ||
| CHEMBL3633656 | 124176 | None | 0 | Mouse | Functional | pIC50 | = | 5.0 | 5.0 | 1 | 5 | Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay |
ChEMBL | 421 | 7 | 1 | 5 | 2.8 | COc1ccc(-c2[nH]c3ccccc3c2C(=O)CN(C)CC(=O)N2CCOCC2)cc1 | 10.1021/acs.jmedchem.5b01254 | ||
| 3401 | 2346 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | NoneNone |
Drug Central | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | None | ||
| 6262 | 2346 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | NoneNone |
Drug Central | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | None | ||
| 725 | 2346 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | NoneNone |
Drug Central | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | None | ||
| 88747248 | 2346 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | NoneNone |
Drug Central | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | None | ||
| CHEMBL446143 | 2346 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | NoneNone |
Drug Central | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | None | ||
| DB00129 | 2346 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | NoneNone |
Drug Central | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | None | ||
| 1549 | 2279 | None | 62 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 3 | NoneNone |
Drug Central | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | None | ||
| 28782 | 2279 | None | 62 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 3 | NoneNone |
Drug Central | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | None | ||
| 6322 | 2279 | None | 62 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 3 | NoneNone |
Drug Central | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | None | ||
| 721 | 2279 | None | 62 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 3 | NoneNone |
Drug Central | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | None | ||
| CHEMBL1485 | 2279 | None | 62 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 3 | NoneNone |
Drug Central | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | None | ||
| DB00125 | 2279 | None | 62 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 3 | NoneNone |
Drug Central | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | None | ||
| 1311 | 2316 | None | 0 | Human | Functional | pEC50 | None | 3.2 | 3.2 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 146 | 4 | 3 | 3 | -1.3 | NC(=O)CC[C@@H](C(=O)O)N | 15576628 | ||
| 4633 | 2316 | None | 0 | Human | Functional | pEC50 | None | 3.2 | 3.2 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 146 | 4 | 3 | 3 | -1.3 | NC(=O)CC[C@@H](C(=O)O)N | 15576628 | ||
| 4634 | 2316 | None | 0 | Human | Functional | pEC50 | None | 3.2 | 3.2 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 146 | 4 | 3 | 3 | -1.3 | NC(=O)CC[C@@H](C(=O)O)N | 15576628 | ||
| 5961 | 2316 | None | 0 | Human | Functional | pEC50 | None | 3.2 | 3.2 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 146 | 4 | 3 | 3 | -1.3 | NC(=O)CC[C@@H](C(=O)O)N | 15576628 | ||
Showing 1 to 50 of 108 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 102331684 | 115317 | None | 0 | Mouse | Binding | pKi | = | 4.1 | 4.1 | - | 1 | Binding affinity to mouse GPRC6A expressed in human tsA201 cells coexpressing GalphaqG66DBinding affinity to mouse GPRC6A expressed in human tsA201 cells coexpressing GalphaqG66D |
ChEMBL | 186 | 4 | 5 | 3 | -1.3 | N=C(N)NCC[C@H]1C[C@@]1(N)C(=O)O | 10.1039/C1MD00186H | ||
| CHEMBL3347673 | 115317 | None | 0 | Mouse | Binding | pKi | = | 4.1 | 4.1 | - | 1 | Binding affinity to mouse GPRC6A expressed in human tsA201 cells coexpressing GalphaqG66DBinding affinity to mouse GPRC6A expressed in human tsA201 cells coexpressing GalphaqG66D |
ChEMBL | 186 | 4 | 5 | 3 | -1.3 | N=C(N)NCC[C@H]1C[C@@]1(N)C(=O)O | 10.1039/C1MD00186H | ||
Showing 1 to 2 of 2 entries