Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 10327 | 3459 | None | 52 | Mouse | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 489 | 6 | 1 | 4 | 6.8 | CNC1CCC(CC1)N(C(=O)c1sc2c(c1Cl)cccc2)Cc1cccc(c1)c1ccncc1 | 10.1021/acs.jmedchem.1c01220 | ||
| 5284330 | 3459 | None | 52 | Mouse | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 489 | 6 | 1 | 4 | 6.8 | CNC1CCC(CC1)N(C(=O)c1sc2c(c1Cl)cccc2)Cc1cccc(c1)c1ccncc1 | 10.1021/acs.jmedchem.1c01220 | ||
| CHEMBL1221983 | 3459 | None | 52 | Mouse | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 489 | 6 | 1 | 4 | 6.8 | CNC1CCC(CC1)N(C(=O)c1sc2c(c1Cl)cccc2)Cc1cccc(c1)c1ccncc1 | 10.1021/acs.jmedchem.1c01220 | ||
| 164612791 | 184850 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1411 | 47 | 2 | 19 | 13.7 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCn4cc(COCCOCCOCCOCCOCCOCCOCCCCCC[C@@H](C)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| CHEMBL4850805 | 184850 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1411 | 47 | 2 | 19 | 13.7 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCn4cc(COCCOCCOCCOCCOCCOCCOCCCCCC[C@@H](C)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| 164609689 | 185158 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1279 | 38 | 2 | 16 | 13.6 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCn4cc(COCCOCCOCCOCCCCCC[C@@H](C)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| CHEMBL4855383 | 185158 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1279 | 38 | 2 | 16 | 13.6 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCn4cc(COCCOCCOCCOCCCCCC[C@@H](C)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| 164610344 | 185327 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1587 | 59 | 2 | 23 | 13.7 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCOCCOCCn4cc(COCCOCCOCCOCCOCCOCCOCCOCCOCCCCCC[C@@H](C)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| CHEMBL4857875 | 185327 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1587 | 59 | 2 | 23 | 13.7 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCOCCOCCn4cc(COCCOCCOCCOCCOCCOCCOCCOCCOCCCCCC[C@@H](C)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| 164617125 | 185440 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1543 | 56 | 2 | 22 | 13.7 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCOCCOCCn4cc(COCCOCCOCCOCCOCCOCCOCCOCCCCCC[C@@H](C)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| CHEMBL4859799 | 185440 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1543 | 56 | 2 | 22 | 13.7 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCOCCOCCn4cc(COCCOCCOCCOCCOCCOCCOCCOCCCCCC[C@@H](C)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| 164620070 | 185784 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1499 | 53 | 2 | 21 | 13.7 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCOCCOCCn4cc(COCCOCCOCCOCCOCCOCCOCCCCCC[C@@H](C)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| CHEMBL4865069 | 185784 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1499 | 53 | 2 | 21 | 13.7 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCOCCOCCn4cc(COCCOCCOCCOCCOCCOCCOCCCCCC[C@@H](C)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| 164627959 | 186507 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1191 | 32 | 2 | 14 | 13.6 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCn4cc(COCCOCCCCCC[C@@H](C)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| CHEMBL4875874 | 186507 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1191 | 32 | 2 | 14 | 13.6 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCn4cc(COCCOCCCCCC[C@@H](C)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| 164624904 | 185705 | None | 0 | Mouse | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1163 | 29 | 3 | 14 | 12.7 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCn4cc(COCCCCCC[C@](C)(O)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| CHEMBL4863797 | 185705 | None | 0 | Mouse | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1163 | 29 | 3 | 14 | 12.7 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCn4cc(COCCCCCC[C@](C)(O)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| 164624752 | 186245 | None | 0 | Mouse | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1251 | 35 | 3 | 16 | 12.7 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCn4cc(COCCOCCOCCCCCC[C@](C)(O)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| CHEMBL4872118 | 186245 | None | 0 | Mouse | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1251 | 35 | 3 | 16 | 12.7 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCn4cc(COCCOCCOCCCCCC[C@](C)(O)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| 164626857 | 186627 | None | 0 | Mouse | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1119 | 26 | 3 | 13 | 12.7 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCn4cc(COCCCCCCC(C)(O)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| CHEMBL4877645 | 186627 | None | 0 | Mouse | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 1119 | 26 | 3 | 13 | 12.7 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCn4cc(COCCCCCCC(C)(O)C5CC[C@H]6[C@@H]7CC=C8C[C@@H](O)CC[C@]8(C)[C@H]7CC[C@]56C)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| 164609131 | 184550 | None | 0 | Mouse | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 519 | 7 | 1 | 5 | 6.8 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OC)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| CHEMBL4846477 | 184550 | None | 0 | Mouse | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 519 | 7 | 1 | 5 | 6.8 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OC)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| 164624113 | 185846 | None | 0 | Mouse | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 806 | 23 | 2 | 13 | 6.0 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCn4cc(COCCO)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| CHEMBL4866116 | 185846 | None | 0 | Mouse | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayAgonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assay |
ChEMBL | 806 | 23 | 2 | 13 | 6.0 | CN[C@H]1CC[C@H](N(Cc2cccc(-c3ccnc(OCCOCCOCCOCCn4cc(COCCO)nn4)c3)c2)C(=O)c2sc3ccccc3c2Cl)CC1 | 10.1021/acs.jmedchem.1c01220 | ||
| 58006515 | 81513 | None | 0 | Mouse | Functional | pIC50 | = | 10 | 10.0 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 509 | 5 | 2 | 5 | 7.3 | C[C@H]1CN(c2ccc3c(Nc4ccc(Cl)c(-c5ncc(-c6ccccc6)[nH]5)c4)nccc3c2)C[C@@H](C)O1 | 10.1016/j.bmcl.2012.09.013 | ||
| CHEMBL2160072 | 81513 | None | 0 | Mouse | Functional | pIC50 | = | 10 | 10.0 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 509 | 5 | 2 | 5 | 7.3 | C[C@H]1CN(c2ccc3c(Nc4ccc(Cl)c(-c5ncc(-c6ccccc6)[nH]5)c4)nccc3c2)C[C@@H](C)O1 | 10.1016/j.bmcl.2012.09.013 | ||
| 23725173 | 81515 | None | 0 | Mouse | Functional | pIC50 | = | 10 | 10.0 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 495 | 5 | 2 | 5 | 6.9 | C[C@@H]1CN(c2ccc3c(Nc4ccc(Cl)c(-c5ncc(-c6ccccc6)[nH]5)c4)nccc3c2)CCO1 | 10.1016/j.bmcl.2012.09.013 | ||
| CHEMBL2160074 | 81515 | None | 0 | Mouse | Functional | pIC50 | = | 10 | 10.0 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 495 | 5 | 2 | 5 | 6.9 | C[C@@H]1CN(c2ccc3c(Nc4ccc(Cl)c(-c5ncc(-c6ccccc6)[nH]5)c4)nccc3c2)CCO1 | 10.1016/j.bmcl.2012.09.013 | ||
| 24788599 | 81518 | None | 0 | Mouse | Functional | pIC50 | = | 10 | 10.0 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 481 | 5 | 2 | 5 | 6.5 | Clc1ccc(Nc2nccc3cc(N4CCOCC4)ccc23)cc1-c1ncc(-c2ccccc2)[nH]1 | 10.1016/j.bmcl.2012.09.013 | ||
| CHEMBL2160077 | 81518 | None | 0 | Mouse | Functional | pIC50 | = | 10 | 10.0 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 481 | 5 | 2 | 5 | 6.5 | Clc1ccc(Nc2nccc3cc(N4CCOCC4)ccc23)cc1-c1ncc(-c2ccccc2)[nH]1 | 10.1016/j.bmcl.2012.09.013 | ||
| 24789011 | 81509 | None | 0 | Mouse | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 510 | 5 | 2 | 6 | 6.7 | C[C@H]1CN(c2ccc3c(Nc4ccc(Cl)c(-c5ncc(-c6ccccc6)[nH]5)c4)nccc3n2)C[C@@H](C)O1 | 10.1016/j.bmcl.2012.09.013 | ||
| CHEMBL2160068 | 81509 | None | 0 | Mouse | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 510 | 5 | 2 | 6 | 6.7 | C[C@H]1CN(c2ccc3c(Nc4ccc(Cl)c(-c5ncc(-c6ccccc6)[nH]5)c4)nccc3n2)C[C@@H](C)O1 | 10.1016/j.bmcl.2012.09.013 | ||
| 24788668 | 81519 | None | 0 | Mouse | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 438 | 5 | 2 | 4 | 5.1 | Cc1ccc(NC(=O)c2ccc(N3CCOCC3)cc2)cc1-c1ncc(-c2ccccc2)[nH]1 | 10.1016/j.bmcl.2012.09.013 | ||
| CHEMBL2160078 | 81519 | None | 0 | Mouse | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 438 | 5 | 2 | 4 | 5.1 | Cc1ccc(NC(=O)c2ccc(N3CCOCC3)cc2)cc1-c1ncc(-c2ccccc2)[nH]1 | 10.1016/j.bmcl.2012.09.013 | ||
| 24788948 | 81511 | None | 0 | Mouse | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 509 | 5 | 2 | 5 | 7.3 | C[C@H]1CN(c2ccc3c(Nc4ccc(Cl)c(-c5ncc(-c6ccccc6)[nH]5)c4)cccc3n2)C[C@@H](C)O1 | 10.1016/j.bmcl.2012.09.013 | ||
| CHEMBL2160070 | 81511 | None | 0 | Mouse | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 509 | 5 | 2 | 5 | 7.3 | C[C@H]1CN(c2ccc3c(Nc4ccc(Cl)c(-c5ncc(-c6ccccc6)[nH]5)c4)cccc3n2)C[C@@H](C)O1 | 10.1016/j.bmcl.2012.09.013 | ||
| 24788207 | 81512 | None | 0 | Mouse | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 509 | 5 | 2 | 5 | 7.3 | C[C@H]1CN(c2ccc3c(Nc4ccc(Cl)c(-c5ncc(-c6ccccc6)[nH]5)c4)ccnc3c2)C[C@@H](C)O1 | 10.1016/j.bmcl.2012.09.013 | ||
| CHEMBL2160071 | 81512 | None | 0 | Mouse | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 509 | 5 | 2 | 5 | 7.3 | C[C@H]1CN(c2ccc3c(Nc4ccc(Cl)c(-c5ncc(-c6ccccc6)[nH]5)c4)ccnc3c2)C[C@@H](C)O1 | 10.1016/j.bmcl.2012.09.013 | ||
| 49840814 | 81508 | None | 0 | Mouse | Functional | pIC50 | = | 9.2 | 9.2 | 1 | 2 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 496 | 5 | 2 | 6 | 6.3 | C[C@@H]1CN(c2ccc3c(Nc4ccc(Cl)c(-c5ncc(-c6ccccc6)[nH]5)c4)nccc3n2)CCO1 | 10.1016/j.bmcl.2012.09.013 | ||
| CHEMBL2160067 | 81508 | None | 0 | Mouse | Functional | pIC50 | = | 9.2 | 9.2 | 1 | 2 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 496 | 5 | 2 | 6 | 6.3 | C[C@@H]1CN(c2ccc3c(Nc4ccc(Cl)c(-c5ncc(-c6ccccc6)[nH]5)c4)nccc3n2)CCO1 | 10.1016/j.bmcl.2012.09.013 | ||
| 24788725 | 81517 | None | 0 | Mouse | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 479 | 5 | 2 | 4 | 7.7 | Clc1ccc(Nc2nccc3cc(N4CCCCC4)ccc23)cc1-c1ncc(-c2ccccc2)[nH]1 | 10.1016/j.bmcl.2012.09.013 | ||
| CHEMBL2160076 | 81517 | None | 0 | Mouse | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 479 | 5 | 2 | 4 | 7.7 | Clc1ccc(Nc2nccc3cc(N4CCCCC4)ccc23)cc1-c1ncc(-c2ccccc2)[nH]1 | 10.1016/j.bmcl.2012.09.013 | ||
| 24788727 | 81520 | None | 0 | Mouse | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 413 | 6 | 2 | 4 | 5.3 | COc1cc(OC)cc(C(=O)Nc2ccc(C)c(-c3ncc(-c4ccccc4)[nH]3)c2)c1 | 10.1016/j.bmcl.2012.09.013 | ||
| CHEMBL2160079 | 81520 | None | 0 | Mouse | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assayAntagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior to Ag1.5-induction measured after 48 hrs by luciferase reporter gene assay |
ChEMBL | 413 | 6 | 2 | 4 | 5.3 | COc1cc(OC)cc(C(=O)Nc2ccc(C)c(-c3ncc(-c4ccccc4)[nH]3)c2)c1 | 10.1016/j.bmcl.2012.09.013 | ||
| 145993194 | 167123 | None | 0 | Mouse | Functional | pIC50 | = | 9 | 9.0 | - | 1 | Antagonist activity at Smo receptor in mouse NIH/3T3 cells harboring GRE-Luc assessed as inhibition of SAG-induced Hh signaling pathway preincubated for 1 to 2 hrs followed by SAG addition and measured after 24 hrs by Bright-Glo luciferase reporter gene assayAntagonist activity at Smo receptor in mouse NIH/3T3 cells harboring GRE-Luc assessed as inhibition of SAG-induced Hh signaling pathway preincubated for 1 to 2 hrs followed by SAG addition and measured after 24 hrs by Bright-Glo luciferase reporter gene assay |
ChEMBL | 586 | 6 | 0 | 7 | 6.6 | CN(C(=O)c1ccc(Oc2ccccc2)cc1C(F)(F)F)C1CCN(c2nnc(-c3ccnn3C)c3ccccc23)CC1 | 10.1039/C7MD00104E | ||
| CHEMBL4288592 | 167123 | None | 0 | Mouse | Functional | pIC50 | = | 9 | 9.0 | - | 1 | Antagonist activity at Smo receptor in mouse NIH/3T3 cells harboring GRE-Luc assessed as inhibition of SAG-induced Hh signaling pathway preincubated for 1 to 2 hrs followed by SAG addition and measured after 24 hrs by Bright-Glo luciferase reporter gene assayAntagonist activity at Smo receptor in mouse NIH/3T3 cells harboring GRE-Luc assessed as inhibition of SAG-induced Hh signaling pathway preincubated for 1 to 2 hrs followed by SAG addition and measured after 24 hrs by Bright-Glo luciferase reporter gene assay |
ChEMBL | 586 | 6 | 0 | 7 | 6.6 | CN(C(=O)c1ccc(Oc2ccccc2)cc1C(F)(F)F)C1CCN(c2nnc(-c3ccnn3C)c3ccccc23)CC1 | 10.1039/C7MD00104E | ||
| 25226761 | 15080 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | -1 | 2 | Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayAntagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assay |
ChEMBL | 477 | 3 | 0 | 5 | 5.1 | C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(C(F)(F)F)cc2)c2ccncc12 | 10.1016/j.bmcl.2010.06.006 | ||
| CHEMBL1209455 | 15080 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | -1 | 2 | Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayAntagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assay |
ChEMBL | 477 | 3 | 0 | 5 | 5.1 | C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(C(F)(F)F)cc2)c2ccncc12 | 10.1016/j.bmcl.2010.06.006 | ||
| 24776445 | 3997 | None | 65 | Mouse | Functional | pIC50 | = | 8.8 | 8.8 | -1 | 6 | Antagonist activity at Smo in mouse Shh-Light 2 cells assessed as inhibition of Shh-induced Gli1-reporter activity after 2 days by dual-luciferase reporter gene methodAntagonist activity at Smo in mouse Shh-Light 2 cells assessed as inhibition of Shh-induced Gli1-reporter activity after 2 days by dual-luciferase reporter gene method |
ChEMBL | 420 | 4 | 1 | 4 | 4.7 | O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl | 10.1016/j.bmc.2012.09.030 | ||
Showing 1 to 50 of 634 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 25253713 | 177166 | None | 6 | Human | Binding | pEC50 | = | 9.3 | 9.3 | - | 0 | Binding affinity to human SMOBinding affinity to human SMO |
ChEMBL | 398 | 6 | 2 | 4 | 4.9 | Cc1cc(C)c(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| CHEMBL4632769 | 177166 | None | 6 | Human | Binding | pEC50 | = | 9.3 | 9.3 | - | 0 | Binding affinity to human SMOBinding affinity to human SMO |
ChEMBL | 398 | 6 | 2 | 4 | 4.9 | Cc1cc(C)c(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| 156019072 | 177985 | None | 0 | Mouse | Binding | pEC50 | = | 9.1 | 9.1 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 409 | 6 | 1 | 4 | 5.6 | Cc1cc(C)c(-c2ccccn2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| CHEMBL4644674 | 177985 | None | 0 | Mouse | Binding | pEC50 | = | 9.1 | 9.1 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 409 | 6 | 1 | 4 | 5.6 | Cc1cc(C)c(-c2ccccn2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| 156013465 | 177603 | None | 0 | Mouse | Binding | pEC50 | = | 9.1 | 9.1 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 429 | 6 | 1 | 5 | 6.0 | Cc1csc(-c2cc(NC(=O)c3ccc(OCc4ccccn4)cc3)c(C)cc2C)n1 | 10.1016/j.bmc.2019.115227 | ||
| CHEMBL4639432 | 177603 | None | 0 | Mouse | Binding | pEC50 | = | 9.1 | 9.1 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 429 | 6 | 1 | 5 | 6.0 | Cc1csc(-c2cc(NC(=O)c3ccc(OCc4ccccn4)cc3)c(C)cc2C)n1 | 10.1016/j.bmc.2019.115227 | ||
| 25253713 | 177166 | None | 6 | Mouse | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 398 | 6 | 2 | 4 | 4.9 | Cc1cc(C)c(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| CHEMBL4632769 | 177166 | None | 6 | Mouse | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 398 | 6 | 2 | 4 | 4.9 | Cc1cc(C)c(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| 156019009 | 177890 | None | 0 | Mouse | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 424 | 6 | 2 | 5 | 5.2 | Cc1cc(C)c(-c2ccc(N)cn2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| CHEMBL4643226 | 177890 | None | 0 | Mouse | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 424 | 6 | 2 | 5 | 5.2 | Cc1cc(C)c(-c2ccc(N)cn2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| 156021408 | 178215 | None | 0 | Mouse | Binding | pEC50 | = | 9.0 | 9.0 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 412 | 6 | 2 | 4 | 5.2 | Cc1cc(C)c(-c2c[nH]nc2C)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| CHEMBL4648026 | 178215 | None | 0 | Mouse | Binding | pEC50 | = | 9.0 | 9.0 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 412 | 6 | 2 | 4 | 5.2 | Cc1cc(C)c(-c2c[nH]nc2C)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| 53344810 | 556 | None | 8 | Human | Binding | pEC50 | = | 8.8 | 8.8 | - | 0 | Binding affinity to human SMOBinding affinity to human SMO |
ChEMBL | 412 | 6 | 1 | 5 | 4.9 | Cn1cnc(c1)c1cc(NC(=O)c2ccc(cc2)OCc2ccccn2)c(cc1C)C | 10.1016/j.bmc.2019.115227 | ||
| 7716 | 556 | None | 8 | Human | Binding | pEC50 | = | 8.8 | 8.8 | - | 0 | Binding affinity to human SMOBinding affinity to human SMO |
ChEMBL | 412 | 6 | 1 | 5 | 4.9 | Cn1cnc(c1)c1cc(NC(=O)c2ccc(cc2)OCc2ccccn2)c(cc1C)C | 10.1016/j.bmc.2019.115227 | ||
| CHEMBL4637222 | 556 | None | 8 | Human | Binding | pEC50 | = | 8.8 | 8.8 | - | 0 | Binding affinity to human SMOBinding affinity to human SMO |
ChEMBL | 412 | 6 | 1 | 5 | 4.9 | Cn1cnc(c1)c1cc(NC(=O)c2ccc(cc2)OCc2ccccn2)c(cc1C)C | 10.1016/j.bmc.2019.115227 | ||
| 156012199 | 177438 | None | 0 | Mouse | Binding | pEC50 | = | 8.8 | 8.8 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 424 | 6 | 2 | 5 | 5.2 | Cc1cc(C)c(-c2cccc(N)n2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| CHEMBL4637249 | 177438 | None | 0 | Mouse | Binding | pEC50 | = | 8.8 | 8.8 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 424 | 6 | 2 | 5 | 5.2 | Cc1cc(C)c(-c2cccc(N)n2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| 10356 | 3236 | None | 58 | Human | Binding | pEC50 | = | 6 | 6.0 | - | 0 | Agonist activity at SMO receptor (unknown origin)Agonist activity at SMO receptor (unknown origin) |
ChEMBL | 520 | 6 | 1 | 8 | 6.9 | C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 | 10.1021/acs.jnatprod.2c00866 | ||
| 5284329 | 3236 | None | 58 | Human | Binding | pEC50 | = | 6 | 6.0 | - | 0 | Agonist activity at SMO receptor (unknown origin)Agonist activity at SMO receptor (unknown origin) |
ChEMBL | 520 | 6 | 1 | 8 | 6.9 | C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 | 10.1021/acs.jnatprod.2c00866 | ||
| CHEMBL1221984 | 3236 | None | 58 | Human | Binding | pEC50 | = | 6 | 6.0 | - | 0 | Agonist activity at SMO receptor (unknown origin)Agonist activity at SMO receptor (unknown origin) |
ChEMBL | 520 | 6 | 1 | 8 | 6.9 | C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 | 10.1021/acs.jnatprod.2c00866 | ||
| 25181471 | 76509 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 0 | Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisInhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis |
ChEMBL | 412 | 6 | 1 | 5 | 4.9 | Cc1ccc(-c2ncc(C)n2C)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmcl.2012.04.104 | ||
| CHEMBL2059862 | 76509 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 0 | Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisInhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis |
ChEMBL | 412 | 6 | 1 | 5 | 4.9 | Cc1ccc(-c2ncc(C)n2C)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmcl.2012.04.104 | ||
| 67378301 | 76079 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisInhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis |
ChEMBL | 436 | 6 | 2 | 6 | 4.6 | Cc1ccc(-c2ncnc3nc[nH]c23)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmcl.2012.04.104 | ||
| CHEMBL2057337 | 76079 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisInhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis |
ChEMBL | 436 | 6 | 2 | 6 | 4.6 | Cc1ccc(-c2ncnc3nc[nH]c23)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmcl.2012.04.104 | ||
| 10326 | 1870 | None | 39 | Mouse | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assayActivity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assay |
ChEMBL | 450 | 10 | 2 | 6 | 5.1 | CCCCCCn1c(=O)c(C(=O)Nc2ccc(cc2)C(=O)OCCC)c(c2c1cccc2)O | 10.1016/j.ejmech.2016.05.062 | ||
| 54683103 | 1870 | None | 39 | Mouse | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assayActivity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assay |
ChEMBL | 450 | 10 | 2 | 6 | 5.1 | CCCCCCn1c(=O)c(C(=O)Nc2ccc(cc2)C(=O)OCCC)c(c2c1cccc2)O | 10.1016/j.ejmech.2016.05.062 | ||
| CHEMBL3947608 | 1870 | None | 39 | Mouse | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assayActivity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assay |
ChEMBL | 450 | 10 | 2 | 6 | 5.1 | CCCCCCn1c(=O)c(C(=O)Nc2ccc(cc2)C(=O)OCCC)c(c2c1cccc2)O | 10.1016/j.ejmech.2016.05.062 | ||
| 134133528 | 143651 | None | 0 | Mouse | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assayActivity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assay |
ChEMBL | 422 | 7 | 2 | 6 | 4.2 | CCCOC(=O)c1ccc(NC(=O)c2c(O)c3cc(C)ccc3n(CCC)c2=O)cc1 | 10.1016/j.ejmech.2016.05.062 | ||
| CHEMBL3899175 | 143651 | None | 0 | Mouse | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assayActivity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assay |
ChEMBL | 422 | 7 | 2 | 6 | 4.2 | CCCOC(=O)c1ccc(NC(=O)c2c(O)c3cc(C)ccc3n(CCC)c2=O)cc1 | 10.1016/j.ejmech.2016.05.062 | ||
| 25253556 | 76512 | None | 11 | Mouse | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 384 | 6 | 2 | 4 | 4.6 | Cc1ccc(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| CHEMBL2059865 | 76512 | None | 11 | Mouse | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 384 | 6 | 2 | 4 | 4.6 | Cc1ccc(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| 156012240 | 177521 | None | 0 | Mouse | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 398 | 6 | 2 | 4 | 4.9 | Cc1ccc(-c2ncc[nH]2)c(C)c1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| CHEMBL4638476 | 177521 | None | 0 | Mouse | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 398 | 6 | 2 | 4 | 4.9 | Cc1ccc(-c2ncc[nH]2)c(C)c1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| 25253556 | 76512 | None | 11 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisInhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis |
ChEMBL | 384 | 6 | 2 | 4 | 4.6 | Cc1ccc(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmcl.2012.04.104 | ||
| CHEMBL2059865 | 76512 | None | 11 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisInhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis |
ChEMBL | 384 | 6 | 2 | 4 | 4.6 | Cc1ccc(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmcl.2012.04.104 | ||
| 10327 | 3459 | None | 52 | Mouse | Binding | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assayAgonist activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assay |
ChEMBL | 489 | 6 | 1 | 4 | 6.8 | CNC1CCC(CC1)N(C(=O)c1sc2c(c1Cl)cccc2)Cc1cccc(c1)c1ccncc1 | 10.1016/j.ejmech.2016.05.062 | ||
| 5284330 | 3459 | None | 52 | Mouse | Binding | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assayAgonist activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assay |
ChEMBL | 489 | 6 | 1 | 4 | 6.8 | CNC1CCC(CC1)N(C(=O)c1sc2c(c1Cl)cccc2)Cc1cccc(c1)c1ccncc1 | 10.1016/j.ejmech.2016.05.062 | ||
| CHEMBL1221983 | 3459 | None | 52 | Mouse | Binding | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assayAgonist activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assay |
ChEMBL | 489 | 6 | 1 | 4 | 6.8 | CNC1CCC(CC1)N(C(=O)c1sc2c(c1Cl)cccc2)Cc1cccc(c1)c1ccncc1 | 10.1016/j.ejmech.2016.05.062 | ||
| 25253556 | 76512 | None | 11 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Displacement of BODIPY-labeled cyclopamine from human SMO transfected in human HeLa cells by competition binding assayDisplacement of BODIPY-labeled cyclopamine from human SMO transfected in human HeLa cells by competition binding assay |
ChEMBL | 384 | 6 | 2 | 4 | 4.6 | Cc1ccc(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| CHEMBL2059865 | 76512 | None | 11 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Displacement of BODIPY-labeled cyclopamine from human SMO transfected in human HeLa cells by competition binding assayDisplacement of BODIPY-labeled cyclopamine from human SMO transfected in human HeLa cells by competition binding assay |
ChEMBL | 384 | 6 | 2 | 4 | 4.6 | Cc1ccc(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| 132991430 | 151916 | None | 0 | Mouse | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Inhibition of Smo in mouse Shh Light2 cells assessed as inhibition of SAG-induced Hh pathway activity by measuring SAG-EC50 at 500 nM measured after 36 hrs by Gli-luciferase reporter gene assay (Rvb = 2.93 nM)Inhibition of Smo in mouse Shh Light2 cells assessed as inhibition of SAG-induced Hh pathway activity by measuring SAG-EC50 at 500 nM measured after 36 hrs by Gli-luciferase reporter gene assay (Rvb = 2.93 nM) |
ChEMBL | 472 | 4 | 1 | 4 | 6.9 | Cc1ccc2c(n1)[C@H]([C@@H](C)C(=O)Nc1ccc(Cl)c(-c3nc4ccccc4n3C)c1)CC[C@H]2C | 10.1021/acs.jmedchem.6b01247 | ||
| CHEMBL3965352 | 151916 | None | 0 | Mouse | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Inhibition of Smo in mouse Shh Light2 cells assessed as inhibition of SAG-induced Hh pathway activity by measuring SAG-EC50 at 500 nM measured after 36 hrs by Gli-luciferase reporter gene assay (Rvb = 2.93 nM)Inhibition of Smo in mouse Shh Light2 cells assessed as inhibition of SAG-induced Hh pathway activity by measuring SAG-EC50 at 500 nM measured after 36 hrs by Gli-luciferase reporter gene assay (Rvb = 2.93 nM) |
ChEMBL | 472 | 4 | 1 | 4 | 6.9 | Cc1ccc2c(n1)[C@H]([C@@H](C)C(=O)Nc1ccc(Cl)c(-c3nc4ccccc4n3C)c1)CC[C@H]2C | 10.1021/acs.jmedchem.6b01247 | ||
| 67374621 | 76511 | None | 3 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisInhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis |
ChEMBL | 398 | 6 | 2 | 4 | 4.9 | Cc1cnc(-c2ccc(C)c(NC(=O)c3ccc(OCc4ccccn4)cc3)c2)[nH]1 | 10.1016/j.bmcl.2012.04.104 | ||
| CHEMBL2059864 | 76511 | None | 3 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisInhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis |
ChEMBL | 398 | 6 | 2 | 4 | 4.9 | Cc1cnc(-c2ccc(C)c(NC(=O)c3ccc(OCc4ccccn4)cc3)c2)[nH]1 | 10.1016/j.bmcl.2012.04.104 | ||
| 54687077 | 146247 | None | 8 | Mouse | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assayActivity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assay |
ChEMBL | 464 | 11 | 2 | 6 | 5.5 | CCCCCCn1c(=O)c(C(=O)Nc2ccc(C(=O)OCCCC)cc2)c(O)c2ccccc21 | 10.1016/j.ejmech.2016.05.062 | ||
| CHEMBL3919826 | 146247 | None | 8 | Mouse | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assayActivity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assay |
ChEMBL | 464 | 11 | 2 | 6 | 5.5 | CCCCCCn1c(=O)c(C(=O)Nc2ccc(C(=O)OCCCC)cc2)c(O)c2ccccc21 | 10.1016/j.ejmech.2016.05.062 | ||
| 68780150 | 177386 | None | 0 | Mouse | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 402 | 6 | 2 | 4 | 4.8 | Cc1cc(F)c(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| CHEMBL4636326 | 177386 | None | 0 | Mouse | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrsInhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs |
ChEMBL | 402 | 6 | 2 | 4 | 4.8 | Cc1cc(F)c(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmc.2019.115227 | ||
| 70694800 | 76522 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisInhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis |
ChEMBL | 395 | 6 | 1 | 4 | 5.3 | Cc1ccc(-c2ccccn2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmcl.2012.04.104 | ||
| CHEMBL2059875 | 76522 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisInhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis |
ChEMBL | 395 | 6 | 1 | 4 | 5.3 | Cc1ccc(-c2ccccn2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 | 10.1016/j.bmcl.2012.04.104 | ||
Showing 1 to 50 of 2,661 entries