Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
17725 15409 79 None - 1 Human 4.0 pEC50 = 4 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 132 0 0 1 0.4 CN(C)C(=S)N(C)C nan
CHEMBL12214 15409 79 None - 1 Human 4.0 pEC50 = 4 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 132 0 0 1 0.4 CN(C)C(=S)N(C)C nan
2723593 172676 47 None - 1 Human 4.8 pEC50 = 4.8 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 118 0 2 2 -0.6 CC(=O)NC(N)=S nan
CHEMBL4524588 172676 47 None - 1 Human 4.8 pEC50 = 4.8 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 118 0 2 2 -0.6 CC(=O)NC(N)=S nan
820777 136181 64 None - 1 Human 4.8 pEC50 = 4.8 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 151 1 1 1 2.4 CC(=S)Nc1ccccc1 nan
CHEMBL3740596 136181 64 None - 1 Human 4.8 pEC50 = 4.8 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 151 1 1 1 2.4 CC(=S)Nc1ccccc1 nan
12496 3052 90 None 2 2 Human 5.7 pEC50 = 5.7 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 152 1 2 1 1.3 C1=CC=C(C=C1)NC(=S)N nan
676454 3052 90 None 2 2 Human 5.7 pEC50 = 5.7 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 152 1 2 1 1.3 C1=CC=C(C=C1)NC(=S)N nan
CHEMBL263376 3052 90 None 2 2 Human 5.7 pEC50 = 5.7 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 152 1 2 1 1.3 C1=CC=C(C=C1)NC(=S)N nan
DB03694 3052 90 None 2 2 Human 5.7 pEC50 = 5.7 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 152 1 2 1 1.3 C1=CC=C(C=C1)NC(=S)N nan
2308 3139 103 None 34 2 Human 5.7 pEC50 = 5.7 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 170 2 2 2 1.4 CCCc1cc(=O)[nH]c(=S)[nH]1 nan
657298 3139 103 None 34 2 Human 5.7 pEC50 = 5.7 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 170 2 2 2 1.4 CCCc1cc(=O)[nH]c(=S)[nH]1 nan
6650 3139 103 None 34 2 Human 5.7 pEC50 = 5.7 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 170 2 2 2 1.4 CCCc1cc(=O)[nH]c(=S)[nH]1 nan
CHEMBL1518 3139 103 None 34 2 Human 5.7 pEC50 = 5.7 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 170 2 2 2 1.4 CCCc1cc(=O)[nH]c(=S)[nH]1 nan
DB00550 3139 103 None 34 2 Human 5.7 pEC50 = 5.7 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 170 2 2 2 1.4 CCCc1cc(=O)[nH]c(=S)[nH]1 nan
700999 97917 77 None - 1 Human 5.6 pEC50 = 5.6 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 228 2 2 1 3.5 S=C(Nc1ccccc1)Nc1ccccc1 nan
CHEMBL275260 97917 77 None - 1 Human 5.6 pEC50 = 5.6 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 228 2 2 1 3.5 S=C(Nc1ccccc1)Nc1ccccc1 nan
1499 2060 43 None -63 36 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C nan
3779 2060 43 None -63 36 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C nan
536 2060 43 None -63 36 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C nan
CHEMBL434 2060 43 None -63 36 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C nan
DB01064 2060 43 None -63 36 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C nan
697057 15108 103 None - 1 Human 6.3 pEC50 = 6.3 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 204 1 2 2 2.1 O=c1cc(-c2ccccc2)[nH]c(=S)[nH]1 nan
CHEMBL1212975 15108 103 None - 1 Human 6.3 pEC50 = 6.3 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 204 1 2 2 2.1 O=c1cc(-c2ccccc2)[nH]c(=S)[nH]1 nan
69794 172946 68 None - 1 Human 4.3 pEC50 = 4.3 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 89 1 0 1 0.5 CN(C)C=S nan
CHEMBL4530853 172946 68 None - 1 Human 4.3 pEC50 = 4.3 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 89 1 0 1 0.5 CN(C)C=S nan
2308 3139 103 None 34 2 Human 8.2 pEC50 = 8.2 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
Drug Central 170 2 2 2 1.4 CCCc1cc(=O)[nH]c(=S)[nH]1 None
657298 3139 103 None 34 2 Human 8.2 pEC50 = 8.2 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
Drug Central 170 2 2 2 1.4 CCCc1cc(=O)[nH]c(=S)[nH]1 None
6650 3139 103 None 34 2 Human 8.2 pEC50 = 8.2 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
Drug Central 170 2 2 2 1.4 CCCc1cc(=O)[nH]c(=S)[nH]1 None
CHEMBL1518 3139 103 None 34 2 Human 8.2 pEC50 = 8.2 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
Drug Central 170 2 2 2 1.4 CCCc1cc(=O)[nH]c(=S)[nH]1 None
DB00550 3139 103 None 34 2 Human 8.2 pEC50 = 8.2 Functional
Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
Drug Central 170 2 2 2 1.4 CCCc1cc(=O)[nH]c(=S)[nH]1 None
1499 2060 43 None -63 36 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
Drug Central 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C None
3779 2060 43 None -63 36 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
Drug Central 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C None
536 2060 43 None -63 36 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
Drug Central 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C None
CHEMBL434 2060 43 None -63 36 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
Drug Central 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C None
DB01064 2060 43 None -63 36 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
Drug Central 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C None
1349907 2463 0 None - 1 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 114 0 1 3 0.7 Cn1ccnc1S 23632915
1745 2463 0 None - 1 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 114 0 1 3 0.7 Cn1ccnc1S 23632915
6649 2463 0 None - 1 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 114 0 1 3 0.7 Cn1ccnc1S 23632915
CHEMBL1515 2463 0 None - 1 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 114 0 1 3 0.7 Cn1ccnc1S 23632915
DB00763 2463 0 None - 1 Human 4.0 pEC50 = 4.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 114 0 1 3 0.7 Cn1ccnc1S 23632915
12495 1804 0 None - 1 Human 4.2 pEC50 = 4.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 129 1 1 2 0.4 C=CC1CNC(=S)O1 20551074
3034683 1804 0 None - 1 Human 4.2 pEC50 = 4.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 129 1 1 2 0.4 C=CC1CNC(=S)O1 20551074
CHEMBL508652 1804 0 None - 1 Human 4.2 pEC50 = 4.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 129 1 1 2 0.4 C=CC1CNC(=S)O1 20551074
12496 3052 90 None 2 2 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 152 1 2 1 1.3 C1=CC=C(C=C1)NC(=S)N 15723792
676454 3052 90 None 2 2 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 152 1 2 1 1.3 C1=CC=C(C=C1)NC(=S)N 15723792
CHEMBL263376 3052 90 None 2 2 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 152 1 2 1 1.3 C1=CC=C(C=C1)NC(=S)N 15723792
DB03694 3052 90 None 2 2 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 152 1 2 1 1.3 C1=CC=C(C=C1)NC(=S)N 15723792
2308 3139 103 None 34 2 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 170 2 2 2 1.4 CCCc1cc(=O)[nH]c(=S)[nH]1 15723792
657298 3139 103 None 34 2 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 170 2 2 2 1.4 CCCc1cc(=O)[nH]c(=S)[nH]1 15723792
6650 3139 103 None 34 2 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 170 2 2 2 1.4 CCCc1cc(=O)[nH]c(=S)[nH]1 15723792
CHEMBL1518 3139 103 None 34 2 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 170 2 2 2 1.4 CCCc1cc(=O)[nH]c(=S)[nH]1 15723792
DB00550 3139 103 None 34 2 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 170 2 2 2 1.4 CCCc1cc(=O)[nH]c(=S)[nH]1 15723792
2268 3121 0 None 1 2 Human 3.7 pIC50 = 3.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 285 7 1 3 2.2 CCCN(S(=O)(=O)c1ccc(cc1)C(=O)O)CCC 21629661
4357 3121 0 None 1 2 Human 3.7 pIC50 = 3.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 285 7 1 3 2.2 CCCN(S(=O)(=O)c1ccc(cc1)C(=O)O)CCC 21629661
4911 3121 0 None 1 2 Human 3.7 pIC50 = 3.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 285 7 1 3 2.2 CCCN(S(=O)(=O)c1ccc(cc1)C(=O)O)CCC 21629661
CHEMBL897 3121 0 None 1 2 Human 3.7 pIC50 = 3.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 285 7 1 3 2.2 CCCN(S(=O)(=O)c1ccc(cc1)C(=O)O)CCC 21629661
DB01032 3121 0 None 1 2 Human 3.7 pIC50 = 3.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 285 7 1 3 2.2 CCCN(S(=O)(=O)c1ccc(cc1)C(=O)O)CCC 21629661


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI