Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 155518674 | 170410 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as activation of 3 uM strychnine-induced intracellular calcium level by FLIPR assayActivity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as activation of 3 uM strychnine-induced intracellular calcium level by FLIPR assay |
ChEMBL | 292 | 1 | 0 | 4 | 3.2 | CC(=O)O[C@H]1C/C=C(\C)CCC2[C@@H](/C=C/1C)OC(=O)[C@H]2C | nan | ||
| CHEMBL4446651 | 170410 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as activation of 3 uM strychnine-induced intracellular calcium level by FLIPR assayActivity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as activation of 3 uM strychnine-induced intracellular calcium level by FLIPR assay |
ChEMBL | 292 | 1 | 0 | 4 | 3.2 | CC(=O)O[C@H]1C/C=C(\C)CCC2[C@@H](/C=C/1C)OC(=O)[C@H]2C | nan | ||
| 155547566 | 173797 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assay |
ChEMBL | 292 | 1 | 0 | 4 | 3.2 | CC(=O)O[C@H]1C/C=C(\C)CC[C@@H]2[C@@H](/C=C/1C)OC(=O)[C@H]2C | nan | ||
| CHEMBL4535452 | 173797 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assay |
ChEMBL | 292 | 1 | 0 | 4 | 3.2 | CC(=O)O[C@H]1C/C=C(\C)CC[C@@H]2[C@@H](/C=C/1C)OC(=O)[C@H]2C | nan | ||
| 68344426 | 175800 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | 3 | 3 | Competitive antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition strychnine-induced intracellular calcium level by measuring strychnine EC50 at 100 uM by FLIPR assay (Rvb = 0.39 +/- 0.08 uM)Competitive antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition strychnine-induced intracellular calcium level by measuring strychnine EC50 at 100 uM by FLIPR assay (Rvb = 0.39 +/- 0.08 uM) |
ChEMBL | 250 | 0 | 1 | 3 | 2.6 | C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)C2CC1 | nan | ||
| CHEMBL4582048 | 175800 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | 3 | 3 | Competitive antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition strychnine-induced intracellular calcium level by measuring strychnine EC50 at 100 uM by FLIPR assay (Rvb = 0.39 +/- 0.08 uM)Competitive antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition strychnine-induced intracellular calcium level by measuring strychnine EC50 at 100 uM by FLIPR assay (Rvb = 0.39 +/- 0.08 uM) |
ChEMBL | 250 | 0 | 1 | 3 | 2.6 | C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)C2CC1 | nan | ||
| 68344426 | 175800 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | 3 | 3 | Competitive antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition strychnine-induced intracellular calcium level by measuring strychnine EC50 at 10 uM by FLIPR assay (Rvb = 0.39 +/- 0.08 uM)Competitive antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition strychnine-induced intracellular calcium level by measuring strychnine EC50 at 10 uM by FLIPR assay (Rvb = 0.39 +/- 0.08 uM) |
ChEMBL | 250 | 0 | 1 | 3 | 2.6 | C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)C2CC1 | nan | ||
| CHEMBL4582048 | 175800 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | 3 | 3 | Competitive antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition strychnine-induced intracellular calcium level by measuring strychnine EC50 at 10 uM by FLIPR assay (Rvb = 0.39 +/- 0.08 uM)Competitive antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition strychnine-induced intracellular calcium level by measuring strychnine EC50 at 10 uM by FLIPR assay (Rvb = 0.39 +/- 0.08 uM) |
ChEMBL | 250 | 0 | 1 | 3 | 2.6 | C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)C2CC1 | nan | ||
| 5360696 | 1406 | None | 18 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -58 | 11 | Agonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assayAgonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 271 | 1 | 0 | 2 | 3.4 | COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C | nan | ||
| 6953 | 1406 | None | 18 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -58 | 11 | Agonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assayAgonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 271 | 1 | 0 | 2 | 3.4 | COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C | nan | ||
| 842 | 1406 | None | 18 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -58 | 11 | Agonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assayAgonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 271 | 1 | 0 | 2 | 3.4 | COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C | nan | ||
| CHEMBL52440 | 1406 | None | 18 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -58 | 11 | Agonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assayAgonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 271 | 1 | 0 | 2 | 3.4 | COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C | nan | ||
| DB00514 | 1406 | None | 18 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -58 | 11 | Agonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assayAgonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 271 | 1 | 0 | 2 | 3.4 | COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C | nan | ||
| 1499 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -63 | 38 | Agonist activity at human TAS2R46 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R46 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
ChEMBL | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | nan | ||
| 3779 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -63 | 38 | Agonist activity at human TAS2R46 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R46 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
ChEMBL | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | nan | ||
| 3779.0 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -63 | 38 | Agonist activity at human TAS2R46 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R46 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
ChEMBL | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | nan | ||
| 536 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -63 | 38 | Agonist activity at human TAS2R46 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R46 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
ChEMBL | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | nan | ||
| CHEMBL434 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -63 | 38 | Agonist activity at human TAS2R46 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R46 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
ChEMBL | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | nan | ||
| DB01064 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -63 | 38 | Agonist activity at human TAS2R46 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R46 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
ChEMBL | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | nan | ||
| 68344426 | 175800 | None | 0 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 3 | 3 | Competitive antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition strychnine-induced intracellular calcium level by measuring strychnine EC50 at 30 uM by FLIPR assay (Rvb = 0.39 +/- 0.08 uM)Competitive antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition strychnine-induced intracellular calcium level by measuring strychnine EC50 at 30 uM by FLIPR assay (Rvb = 0.39 +/- 0.08 uM) |
ChEMBL | 250 | 0 | 1 | 3 | 2.6 | C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)C2CC1 | nan | ||
| CHEMBL4582048 | 175800 | None | 0 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 3 | 3 | Competitive antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition strychnine-induced intracellular calcium level by measuring strychnine EC50 at 30 uM by FLIPR assay (Rvb = 0.39 +/- 0.08 uM)Competitive antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition strychnine-induced intracellular calcium level by measuring strychnine EC50 at 30 uM by FLIPR assay (Rvb = 0.39 +/- 0.08 uM) |
ChEMBL | 250 | 0 | 1 | 3 | 2.6 | C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)C2CC1 | nan | ||
| 2360 | 3693 | None | 28 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 19 | 2 | Agonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assayAgonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 334 | 0 | 0 | 3 | 2.1 | O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 | nan | ||
| 2484 | 3693 | None | 28 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 19 | 2 | Agonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assayAgonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 334 | 0 | 0 | 3 | 2.1 | O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 | nan | ||
| 347 | 3693 | None | 28 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 19 | 2 | Agonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assayAgonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 334 | 0 | 0 | 3 | 2.1 | O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 | nan | ||
| 441071 | 3693 | None | 28 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 19 | 2 | Agonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assayAgonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 334 | 0 | 0 | 3 | 2.1 | O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 | nan | ||
| CHEMBL227934 | 3693 | None | 28 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 19 | 2 | Agonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assayAgonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 334 | 0 | 0 | 3 | 2.1 | O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 | nan | ||
| DB15954 | 3693 | None | 28 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 19 | 2 | Agonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assayAgonist activity at human TAS2R46 stably expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 334 | 0 | 0 | 3 | 2.1 | O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 | nan | ||
| 155559967 | 175005 | None | 0 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | Activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as activation of 3 uM strychnine-induced intracellular calcium level by FLIPR assayActivity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as activation of 3 uM strychnine-induced intracellular calcium level by FLIPR assay |
ChEMBL | 234 | 0 | 0 | 2 | 3.6 | C/C1=C\[C@H]2OC(=O)[C@@H](C)C2CC/C(C)=C/CC1 | nan | ||
| CHEMBL4564347 | 175005 | None | 0 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | Activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as activation of 3 uM strychnine-induced intracellular calcium level by FLIPR assayActivity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as activation of 3 uM strychnine-induced intracellular calcium level by FLIPR assay |
ChEMBL | 234 | 0 | 0 | 2 | 3.6 | C/C1=C\[C@H]2OC(=O)[C@@H](C)C2CC/C(C)=C/CC1 | nan | ||
| 6917068 | 188300 | None | 0 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | Agonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assay |
ChEMBL | 234 | 0 | 0 | 2 | 3.6 | C/C1=C\[C@H]2OC(=O)[C@@H](C)[C@@H]2CC/C(C)=C/CC1 | nan | ||
| CHEMBL499003 | 188300 | None | 0 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | Agonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assay |
ChEMBL | 234 | 0 | 0 | 2 | 3.6 | C/C1=C\[C@H]2OC(=O)[C@@H](C)[C@@H]2CC/C(C)=C/CC1 | nan | ||
| 5316108 | 169633 | None | 0 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | Activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as activation of 3 uM strychnine-induced intracellular calcium level by FLIPR assayActivity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as activation of 3 uM strychnine-induced intracellular calcium level by FLIPR assay |
ChEMBL | 232 | 0 | 0 | 2 | 3.6 | C=C1C(=O)O[C@@H]2/C=C(\C)CC/C=C(\C)CCC12 | nan | ||
| CHEMBL4435198 | 169633 | None | 0 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | Activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as activation of 3 uM strychnine-induced intracellular calcium level by FLIPR assayActivity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as activation of 3 uM strychnine-induced intracellular calcium level by FLIPR assay |
ChEMBL | 232 | 0 | 0 | 2 | 3.6 | C=C1C(=O)O[C@@H]2/C=C(\C)CC/C=C(\C)CCC12 | nan | ||
| 5281437 | 208644 | None | 41 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | Agonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assay |
ChEMBL | 232 | 0 | 0 | 2 | 3.6 | C=C1C(=O)O[C@@H]2/C=C(\C)CC/C=C(\C)CC[C@@H]12 | nan | ||
| CHEMBL86416 | 208644 | None | 41 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | Agonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assay |
ChEMBL | 232 | 0 | 0 | 2 | 3.6 | C=C1C(=O)O[C@@H]2/C=C(\C)CC/C=C(\C)CC[C@@H]12 | nan | ||
| 68344426 | 175800 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | 3 | 3 | Antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 100 uM absinthin-induced intracellular calcium level 100 uM by FLIPR assayAntagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 100 uM absinthin-induced intracellular calcium level 100 uM by FLIPR assay |
ChEMBL | 250 | 0 | 1 | 3 | 2.6 | C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)C2CC1 | nan | ||
| CHEMBL4582048 | 175800 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | 3 | 3 | Antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 100 uM absinthin-induced intracellular calcium level 100 uM by FLIPR assayAntagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 100 uM absinthin-induced intracellular calcium level 100 uM by FLIPR assay |
ChEMBL | 250 | 0 | 1 | 3 | 2.6 | C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)C2CC1 | nan | ||
| 23259348 | 170016 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | 1 | 3 | Antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of absinthin-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of absinthin-induced increase in intracellular calcium level by FLIPR assay |
ChEMBL | 250 | 0 | 1 | 3 | 2.6 | C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)[C@@H]2CC1 | nan | ||
| CHEMBL4440983 | 170016 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | 1 | 3 | Antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of absinthin-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of absinthin-induced increase in intracellular calcium level by FLIPR assay |
ChEMBL | 250 | 0 | 1 | 3 | 2.6 | C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)[C@@H]2CC1 | nan | ||
| 68344426 | 175800 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | 3 | 3 | Antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 3 uM strychnine-induced intracellular calcium level 100 uM by FLIPR assayAntagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 3 uM strychnine-induced intracellular calcium level 100 uM by FLIPR assay |
ChEMBL | 250 | 0 | 1 | 3 | 2.6 | C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)C2CC1 | nan | ||
| CHEMBL4582048 | 175800 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | 3 | 3 | Antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 3 uM strychnine-induced intracellular calcium level 100 uM by FLIPR assayAntagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 3 uM strychnine-induced intracellular calcium level 100 uM by FLIPR assay |
ChEMBL | 250 | 0 | 1 | 3 | 2.6 | C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)C2CC1 | nan | ||
| 68344426 | 175800 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | 3 | 3 | Antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 3 uM strychnine-induced intracellular calcium level by FLIPR assayAntagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 3 uM strychnine-induced intracellular calcium level by FLIPR assay |
ChEMBL | 250 | 0 | 1 | 3 | 2.6 | C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)C2CC1 | nan | ||
| CHEMBL4582048 | 175800 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | 3 | 3 | Antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 3 uM strychnine-induced intracellular calcium level by FLIPR assayAntagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 3 uM strychnine-induced intracellular calcium level by FLIPR assay |
ChEMBL | 250 | 0 | 1 | 3 | 2.6 | C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)C2CC1 | nan | ||
| 23259348 | 170016 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | 1 | 3 | Antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of strychnine-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of strychnine-induced increase in intracellular calcium level by FLIPR assay |
ChEMBL | 250 | 0 | 1 | 3 | 2.6 | C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)[C@@H]2CC1 | nan | ||
| CHEMBL4440983 | 170016 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | 1 | 3 | Antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of strychnine-induced increase in intracellular calcium level by FLIPR assayAntagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of strychnine-induced increase in intracellular calcium level by FLIPR assay |
ChEMBL | 250 | 0 | 1 | 3 | 2.6 | C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)[C@@H]2CC1 | nan | ||
| 155550031 | 174013 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | Antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 300 uM picrotoxinin-induced intracellular calcium level 100 uM by FLIPR assayAntagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 300 uM picrotoxinin-induced intracellular calcium level 100 uM by FLIPR assay |
ChEMBL | 252 | 0 | 1 | 3 | 2.7 | C/C1=C\C[C@H](O)[C@@H](C)C[C@H]2OC(=O)[C@@H](C)C2CC1 | nan | ||
| CHEMBL4540311 | 174013 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | Antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 300 uM picrotoxinin-induced intracellular calcium level 100 uM by FLIPR assayAntagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 300 uM picrotoxinin-induced intracellular calcium level 100 uM by FLIPR assay |
ChEMBL | 252 | 0 | 1 | 3 | 2.7 | C/C1=C\C[C@H](O)[C@@H](C)C[C@H]2OC(=O)[C@@H](C)C2CC1 | nan | ||
| 68344591 | 170516 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | Antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of picrotoxinin-induced intracellular calcium level by FLIPR assayAntagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of picrotoxinin-induced intracellular calcium level by FLIPR assay |
ChEMBL | 252 | 0 | 1 | 3 | 2.7 | C/C1=C\C[C@H](O)[C@@H](C)C[C@H]2OC(=O)[C@@H](C)[C@@H]2CC1 | nan | ||
| CHEMBL4448202 | 170516 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | Antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of picrotoxinin-induced intracellular calcium level by FLIPR assayAntagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of picrotoxinin-induced intracellular calcium level by FLIPR assay |
ChEMBL | 252 | 0 | 1 | 3 | 2.7 | C/C1=C\C[C@H](O)[C@@H](C)C[C@H]2OC(=O)[C@@H](C)[C@@H]2CC1 | nan | ||
| 155550031 | 174013 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | Antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 30 uM andrographolide-induced intracellular calcium level 100 uM by FLIPR assayAntagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of 30 uM andrographolide-induced intracellular calcium level 100 uM by FLIPR assay |
ChEMBL | 252 | 0 | 1 | 3 | 2.7 | C/C1=C\C[C@H](O)[C@@H](C)C[C@H]2OC(=O)[C@@H](C)C2CC1 | nan | ||
Showing 1 to 50 of 131 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
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| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
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Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
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| No data available in table | ||||||||||||||||||||||
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