MC1 receptor (a0a6m3w5m8_9muri)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC1 receptor

GENE

Mc1r

ORGANISM

lesser bandicoot rat (Bandicota bengalensis)

ALT. NAMES

Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1

SOURCE

TREMBL

SEQUENCE

N-term        
M
P
T
Q
G
P
L
K
R
L
10
                   
L
G
S
L
N
S
T
S
I
T
20
                   
T
P
P
L
G
L
A
T
N
Q
30
                   
T
G
S
W
C
L
H
V
S
I
40
TM1              
P
D
G
L
F
L
S
L
G
L
50
                   
V
S
L
V
E
N
V
L
V
V
60
            ICL1
V
A
I
I
K
N
R
N
L
H
70
TM2              
S
P
M
Y
Y
F
I
C
C
L
80
                   
A
L
S
D
L
M
V
S
V
S
90
                   
I
V
L
E
T
T
I
I
L
L
100
        ECL1    
L
E
A
G
M
L
V
A
R
A
110
TM3              
A
L
V
Q
Q
L
D
N
V
I
120
                   
N
V
L
I
C
G
S
M
V
S
130
                   
S
L
C
F
L
G
V
I
A
I
140
                   
D
R
Y
I
S
I
F
Y
A
L
150
ICL2     TM4  
R
Y
H
S
I
V
T
L
S
R
160
                   
A
R
R
A
V
M
G
I
W
V
170
                   
V
S
I
V
S
S
T
L
F
I
180
    ECL2 TM5  
T
Y
Y
K
H
T
A
V
L
L
190
                   
C
L
V
T
F
F
L
A
M
L
200
                   
A
L
M
A
I
L
Y
V
H
M
210
                   
L
S
R
A
C
Q
H
A
R
G
220
            ICL3
I
A
Q
L
H
K
R
R
H
S
230
    TM6          
I
R
Q
G
F
C
L
K
G
A
240
                   
A
T
L
T
I
L
L
G
I
F
250
                   
F
L
C
W
G
P
F
F
L
H
260
                   
L
L
L
I
V
L
C
P
Q
H
270
ECL3            
P
T
C
S
C
I
F
K
N
F
280
TM7              
N
L
F
L
I
L
I
I
L
S
290
                   
S
I
V
D
P
L
I
Y
A
F
300
  H8              
R
S
Q
E
L
R
M
T
L
K
310
C-term  
E
V
L
L
C
S
W

LINKS

UniProt

DIAGRAMS

7TM

ICL1 R N L H ICL1ECL1 M L V A ECL1ICL2 A L R Y H S I V ICL2ECL2 Y K ECL2ICL3 R R H S I R ICL3ECL3 P Q H P T C S C I F K ECL3N-term M P T Q G P L K R L L G S L N S T S I T T P P L G L A T N Q T G S W C L H V S I N-termC-term L K E V L L C S W C-term P D G L F L S L G L V S L V E N V L V V V A I I K N S P M Y Y F I C C L A L S D L M V S V S I V L E T T I I L L L E A G R A A L V Q Q L D N V I N V L I C G S M V S S L C F L G V I A I D R Y I S I F Y T L S R A R R A V M G I W V V S I V S S T L F I T Y H T A V L L C L V T F F L A M L A L M A I L Y V H M L S R A C Q H A R G I A Q L H K Q G F C L K G A A T L T I L L G I F F L C W G P F F L H L L L I V L C N F N L F L I L I I L S S I V D P L I Y A F R S Q E L R M T
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

V N E V L S V L G L S L F L G D P 1 C C L A L S D L M V S V S I V L E T T I 2 V G L F C L S S V M S G C I L V N I V N 3 A R R A V M G I W V V S I V S S T L F I 4 Y L I A M L A L M A L F F T V L C L L V 5 T I L L G I F F L C W G P F F L H L L L 6 L P D V I S S L I I L I L F L N F N 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available