MC2 receptor (g1pvr8_myolu)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC2 receptor

GENE

MC2R

ORGANISM

Little brown bat (Myotis lucifugus)

ALT. NAMES

Adrenocorticotropic hormone receptor, Adrenocorticotropin receptor, Melanocortin receptor 2

SOURCE

TREMBL

SEQUENCE

N-term        
V
L
S
P
Q
L
G
L
I
L
10
                   
L
S
M
L
N
M
S
G
C
L
20
                   
A
Y
R
L
P
R
A
Q
A
V
30
                   
K
K
K
G
P
E
H
L
L
S
40
                   
P
L
N
P
A
T
P
P
S
Q
50
              TM1
N
C
P
H
V
V
L
P
E
E
60
                   
I
F
F
T
I
S
I
A
G
V
70
                   
L
E
N
L
I
V
L
L
A
V
80
      ICL1 TM2
I
K
N
K
N
L
Q
A
P
M
90
                   
Y
F
F
I
C
S
L
A
I
S
100
                   
D
M
L
G
S
L
Y
K
I
L
110
                   
E
N
I
L
I
M
L
R
N
K
120
  ECL1   TM3  
G
Y
L
K
P
R
G
N
F
E
130
                   
T
T
A
D
D
I
I
D
S
L
140
                   
F
I
L
S
L
L
G
S
I
F
150
                   
S
L
S
V
I
A
A
D
R
Y
160
          ICL2  
I
T
I
F
H
A
L
Q
Y
H
170
      TM4        
S
I
V
T
M
R
R
A
V
A
180
                   
V
L
A
V
I
W
T
C
C
T
190
                   
C
S
G
I
T
M
A
I
F
S
200
ECL2 TM5      
H
R
I
P
T
V
I
T
F
T
210
                   
S
L
F
P
L
M
L
V
F
I
220
                   
L
C
L
Y
V
H
M
F
L
L
230
                   
A
R
S
H
A
R
K
I
S
T
240
ICL3 TM6      
L
S
R
A
N
M
K
G
A
I
250
                   
T
L
T
I
L
L
G
V
F
I
260
                   
F
C
W
A
P
F
V
L
H
V
270
            ECL3
L
L
M
T
F
C
P
N
N
P
280
TM7              
Y
C
V
C
Y
M
S
L
F
Q
290
                   
V
N
G
M
L
I
M
C
N
A
300
                   
V
I
D
P
F
I
Y
A
F
R
310
H8                
S
P
E
L
R
E
A
F
K
K
320
                   
M
I
F
C
S
S
I
C
N
S
330
C-term
L
V
L
C

LINKS

UniProt

DIAGRAMS

7TM

ICL1 K N L Q ICL1ECL1 Y L K P R ECL1ICL2 A L Q Y H S I V ICL2ECL2 H ECL2ICL3 T L S R A ICL3ECL3 P N ECL3N-term V L S P Q L G L I L L S M L N M S G C L A Y R L P R A Q A V K K K G P E H L L S P L N P A T P P S Q N C P H V V L N-termC-term S I C N S L V L C C-term P E E I F F T I S I A G V L E N L I V L L A V I K N A P M Y F F I C S L A I S D M L G S L Y K I L E N I L I M L R N K G G N F E T T A D D I I D S L F I L S L L G S I F S L S V I A A D R Y I T I F H T M R R A V A V L A V I W T C C T C S G I T M A I F S R I P T V I T F T S L F P L M L V F I L C L Y V H M F L L A R S H A R K I S N M K G A I T L T I L L G V F I F C W A P F V L H V L L M T F C N P Y C V C Y M S L F Q V N G M L I M C N A V I D P F I Y A F R S P E F K K S L R E A M I F C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N E L V G A I S I T F F I E E P 1 C S L A I S D M L G S L Y K I L E N I L 2 V S L S F I S G L L S L I F L S D I I D 3 A V A V L A V I W T C C T C S G I T M A 4 Y L C L I F V L M L P F L S T F T I V T 5 T I L L G V F I F C W A P F V L H V L L 6 F P D I V A N C M I L M G N V Q F L S 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available