MC1 receptor (mshr_leocy)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC1 receptor

GENE

MC1R

ORGANISM

Golden-headed lion tamarin (Leontopithecus chrysomelas)

ALT. NAMES

Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
P
M
Q
G
A
Q
R
K
L
10
                   
L
G
S
L
N
S
T
P
T
A
20
                   
T
S
N
L
G
L
A
A
N
R
30
                   
T
G
A
P
C
L
E
L
P
I
40
TM1              
P
D
G
L
F
L
S
L
G
L
50
                   
V
S
L
V
E
N
V
L
V
V
60
            ICL1
A
A
I
A
K
N
R
N
L
H
70
TM2              
S
S
M
Y
C
F
I
C
C
L
80
                   
A
L
S
D
L
L
V
S
G
S
90
                   
N
M
L
E
A
G
V
L
A
T
100
        TM3      
R
A
S
V
V
Q
Q
L
H
N
110
                   
T
I
D
V
L
T
C
S
S
M
120
                   
L
C
S
L
C
F
L
G
A
I
130
                   
A
V
D
R
Y
I
S
I
F
Y
140
ICL2            
A
L
R
Y
H
S
I
M
T
L
150
TM4              
P
R
A
Q
R
A
V
A
A
I
160
                   
W
V
A
S
V
L
S
S
T
L
170
        ECL2 TM5
F
I
T
Y
Y
D
H
A
A
V
180
                 
L
L
C
L
V
V
F
F
L
A
190
                   
M
L
V
L
M
A
V
L
Y
V
200
                   
H
M
L
A
W
A
C
Q
H
A
210
                   
Q
G
I
I
R
L
H
K
R
Q
220
ICL3 TM6      
P
P
A
H
K
G
F
G
L
R
230
                   
G
A
A
T
L
T
I
L
L
G
240
                   
I
F
F
L
C
W
G
P
F
F
250
                   
L
R
L
T
L
V
V
F
C
P
260
ECL3            
Q
H
L
T
C
N
C
I
F
K
270
TM7              
N
F
K
V
F
L
T
L
I
I
280
                   
C
N
T
I
I
D
P
L
I
Y
290
      H8          
A
F
R
S
Q
E
L
R
R
T
300
C-term        
L
K
E
V
L
G
R
G
R
W
310

LINKS

UniProt

DIAGRAMS

7TM

ICL1 R N L H ICL1ICL2 A L R Y H S I M ICL2ECL2 Y D ECL2ICL3 R Q P P A H ICL3ECL3 P Q H L T C N C I F K ECL3N-term M P M Q G A Q R K L L G S L N S T P T A T S N L G L A A N R T G A P C L E L P I N-termC-term L K E V L G R G R W C-term P D G L F L S L G L V S L V E N V L V V A A I A K N S S M Y C F I C C L A L S D L L V S G S N M L E A G V L A T R A S V V Q Q L H N T I D V L T C S S M L C S L C F L G A I A V D R Y I S I F Y T L P R A Q R A V A A I W V A S V L S S T L F I T Y H A A V L L C L V V F F L A M L V L M A V L Y V H M L A W A C Q H A Q G I I R L H K K G F G L R G A A T L T I L L G I F F L C W G P F F L R L T L V V F C N F K V F L T L I I C N T I I D P L I Y A F R S Q E L R R T
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

V N E V L S V L G L S L F L G D P 1 C C L A L S D L L V S G S N M L E A G V 2 A G L F C L S C L M S S C T L V D I T N 3 A Q R A V A A I W V A S V L S S T L F I 4 Y L V A M L V L M A L F F V V L C L L V 5 T I L L G I F F L C W G P F F L R L T L 6 L P D I I T N C I I L T L F V K F N 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available