MRGPRF (w8w3h4_dipor)

FAMILY

Class A (Rhodopsin) Orphan receptors Class A orphans MRGPRF

GENE

MGRC (Mrgprf)

ORGANISM

Ord's kangaroo rat (Dipodomys ordii)

ALT. NAMES

Mas-related G protein-coupled receptor C, Mas-related G-protein coupled receptor member F

SOURCE

TREMBL

SEQUENCE

N-term        
M
C
P
G
V
S
E
A
P
E
10
                   
L
Y
S
R
G
F
L
T
I
E
20
              TM1
Q
I
A
L
L
P
P
P
A
V
30
                   
M
N
Y
I
F
L
L
L
C
L
40
                   
C
G
L
V
G
N
G
L
V
L
50
                   
W
F
F
G
F
S
I
K
R
T
60
TM2              
P
F
S
I
Y
F
L
H
L
A
70
                   
G
A
D
G
T
Y
L
F
S
K
80
                   
A
V
F
S
L
L
N
T
G
G
90
ECL1   TM3    
F
L
G
P
F
A
D
Y
I
R
100
                   
G
V
S
R
I
L
G
L
C
T
110
                   
F
L
A
S
V
S
L
L
P
A
120
                   
V
S
T
E
R
C
L
S
V
I
130
  ICL2          
F
P
A
W
Y
W
R
R
R
P
140
TM4              
K
R
L
S
A
V
V
C
A
L
150
                   
L
W
L
L
S
I
L
A
T
A
160
            ECL2
I
H
S
Y
F
C
V
F
L
G
170
            TM5  
R
E
V
S
G
R
A
C
R
H
180
                   
T
D
I
S
L
G
V
L
L
F
190
                   
L
L
F
C
P
L
M
V
L
P
200
                   
C
L
A
L
I
L
H
V
E
C
210
      ICL3 TM6
W
A
R
R
R
Q
R
S
A
K
220
                   
L
N
H
V
V
L
A
L
V
S
230
                   
I
F
L
V
S
S
I
Y
L
G
240
                   
I
D
W
F
L
F
W
V
F
H
250
ECL3 TM7      
I
P
A
P
F
P
E
Y
V
T
260
                   
D
L
C
I
C
I
N
S
S
A
270
                H8
K
P
V
V
Y
F
L
A
G
R
280
                   
D
K
S
Q
R
L
W
E
P
L
290
        C-term
R
V
V
F
Q
R
A
L
R
D
300
                   
G
A
E
P
G
E
A
A
G
S
310
                   
T
P
N
T
V
T
M
E
M
Q
320
             
C
P
S
G
N
A
S

LINKS

UniProt

DIAGRAMS

7TM

ICL1 K R ICL1ECL1 F L G P F ECL1ICL2 P A W Y W R R R ICL2ECL2 V F L G R E V S G R ECL2ICL3 R R Q R ICL3ECL3 H I P A ECL3N-term M C P G V S E A P E L Y S R G F L T I E Q I A L L P P N-termC-term Q R A L R D G A E P G E A A G S T P N T V T M E M Q C P S G N A S C-term P A V M N Y I F L L L C L C G L V G N G L V L W F F G F S I T P F S I Y F L H L A G A D G T Y L F S K A V F S L L N T G G A D Y I R G V S R I L G L C T F L A S V S L L P A V S T E R C L S V I F P K R L S A V V C A L L W L L S I L A T A I H S Y F C A C R H T D I S L G V L L F L L F C P L M V L P C L A L I L H V E C W A R S A K L N H V V L A L V S I F L V S S I Y L G I D W F L F W V F P F P E Y V T D L C I C I N S S A K P V V Y F L A G R D L W E V F K S Q R P L R V
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N G V L G C L C L L L F I Y N M V A P 1 L H L A G A D G T Y L F S K A V F S L L 2 A P L L S V S A L F T C L G L I R S V G 3 S A V V C A L L W L L S I L A T A I H S 4 A L C P L V M L P C F L L F L L V G L S I 5 L A L V S I F L V S S I Y L G I D W F L 6 V P K A S S N I C I C L D T V Y E P F 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available