MC2 receptor (a0a1s3a4i7_erieu)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC2 receptor

GENE

MC2R

ORGANISM

Western European hedgehog (Erinaceus europaeus)

ALT. NAMES

Adrenocorticotropic hormone receptor, Adrenocorticotropin receptor, Melanocortin receptor 2

SOURCE

TREMBL

SEQUENCE

N-term        
M
E
Y
L
T
N
L
H
E
N
10
                   
I
N
K
T
A
R
N
N
S
D
20
            TM1  
C
P
W
V
V
L
P
E
E
I
30
                   
F
F
T
I
S
I
I
G
V
L
40
                   
E
N
L
L
V
L
L
A
V
I
50
    ICL1 TM2  
K
N
K
N
L
Q
S
P
M
Y
60
                   
F
F
I
C
S
L
A
I
S
D
70
                   
M
L
G
S
L
Y
K
I
L
E
80
                   
N
I
L
I
M
V
K
N
M
G
90
ECL1   TM3    
Y
I
Q
P
G
G
S
F
E
T
100
                   
T
T
D
D
I
I
D
S
L
F
110
                   
I
L
S
L
L
G
S
I
F
S
120
                   
L
S
M
I
A
T
D
R
Y
I
130
        ICL2    
T
I
F
H
A
L
Q
Y
Y
S
140
    TM4          
I
V
T
M
R
R
A
I
I
V
150
                   
L
T
V
I
W
M
C
C
V
G
160
                   
S
G
I
T
M
A
I
F
S
H
170
TM5              
H
I
P
T
V
I
T
F
T
S
180
                   
L
F
L
L
M
L
V
F
I
L
190
                   
C
L
Y
V
H
M
F
L
L
A
200
                   
R
S
H
T
R
K
I
S
A
L
210
ICL3 TM6      
P
R
A
N
M
K
G
A
I
T
220
                   
L
T
I
L
L
G
V
F
I
F
230
                   
C
W
A
P
F
V
L
H
V
L
240
          ECL3 TM7
L
V
V
F
C
P
N
N
P
Y
250
               
C
A
C
Y
M
S
L
F
Q
V
260
                   
N
G
M
L
I
M
C
N
A
V
270
                   
I
D
P
F
I
Y
A
F
R
S
280
H8                
P
E
L
R
E
A
F
R
K
M
290
        C-term
I
F
C
N
R
Y
Q

LINKS

UniProt

DIAGRAMS

7TM

ICL1 K N L Q ICL1ECL1 Y I Q P G ECL1ICL2 A L Q Y Y S I V ICL2ECL2 H ECL2ICL3 A L P R A ICL3ECL3 P N ECL3N-term M E Y L T N L H E N I N K T A R N N S D C P W V V L N-termC-term R Y Q C-term P E E I F F T I S I I G V L E N L L V L L A V I K N S P M Y F F I C S L A I S D M L G S L Y K I L E N I L I M V K N M G G S F E T T T D D I I D S L F I L S L L G S I F S L S M I A T D R Y I T I F H T M R R A I I V L T V I W M C C V G S G I T M A I F S H I P T V I T F T S L F L L M L V F I L C L Y V H M F L L A R S H T R K I S N M K G A I T L T I L L G V F I F C W A P F V L H V L L V V F C N P Y C A C Y M S L F Q V N G M L I M C N A V I D P F I Y A F R S P E F R K N L R E A M I F C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N E L V G I I S I T F F I E E P 1 C S L A I S D M L G S L Y K I L E N I L 2 M S L S F I S G L L S L I F L S D I I D 3 A I I V L T V I W M C C V G S G I T M A 4 Y L C L I F V L M L L F L S T F T I V T 5 T I L L G V F I F C W A P F V L H V L L 6 F P D I V A N C M I L M G N V Q F L S 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available