MC2 receptor (a0a665ta46_echna)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC2 receptor

GENE

mc2r

ORGANISM

Live sharksucker (Echeneis naucrates)

ALT. NAMES

Adrenocorticotropic hormone receptor, Adrenocorticotropin receptor, Melanocortin receptor 2

SOURCE

TREMBL

SEQUENCE

N-term        
Y
N
N
D
H
L
K
L
I
G
10
                   
E
P
P
W
Q
T
M
N
T
T
20
                   
L
V
T
Q
S
D
C
P
D
V
30
    TM1          
K
V
P
I
F
L
F
F
T
I
40
                   
G
L
A
S
L
A
E
N
V
L
50
                   
V
V
V
A
V
T
C
N
R
N
60
ICL1 TM2      
L
H
S
P
M
Y
Y
F
I
C
70
                   
S
L
A
A
F
N
T
I
A
S
80
                   
L
T
K
T
C
E
N
L
M
I
90
            ECL1
T
F
A
D
V
G
H
L
E
K
100
  TM3            
K
G
P
S
E
T
K
L
D
D
110
                   
V
M
D
C
L
L
C
M
S
F
120
                   
L
G
S
I
S
S
F
L
A
I
130
                   
A
V
D
R
Y
I
T
I
F
H
140
ICL2            
A
L
R
Y
H
N
I
M
T
M
150
TM4              
Q
R
T
R
A
I
L
G
V
I
160
                   
W
I
T
C
G
M
S
A
I
S
170
          ECL2 TM5
M
V
T
F
F
A
S
T
F
I
180
               
M
I
C
F
V
S
F
F
I
I
190
                   
S
L
V
I
I
C
F
L
Y
V
200
                   
Y
M
F
M
L
A
R
I
H
A
210
        ICL3    
R
K
I
A
A
L
P
S
S
G
220
                   
G
R
N
C
H
H
Q
Q
R
W
230
    TM6          
G
S
S
M
R
G
A
L
T
L
240
                   
T
I
L
F
G
A
F
M
V
C
250
                   
W
G
P
F
F
L
H
L
I
I
260
        ECL3 TM7
I
M
V
C
P
T
N
P
Y
C
270
                 
E
C
Y
R
S
L
F
Q
L
H
280
                   
M
V
L
L
M
S
H
A
L
I
290
                H8
D
P
T
I
Y
A
F
R
S
P
300
                   
E
L
R
E
T
F
K
K
I
S
310
      C-term  
Y
G
C
S
S
K
N
L
P
F
320
   
F
L

LINKS

DIAGRAMS

7TM

ICL1 R N L H ICL1ECL1 H L E K K ECL1ICL2 A L R Y H N I M ICL2ECL2 A ECL2ICL3 A L P S S G G R N C H H Q Q R W G S ICL3ECL3 P T ECL3N-term Y N N D H L K L I G E P P W Q T M N T T L V T Q S D C P D V K V N-termC-term S S K N L P F F L C-term P I F L F F T I G L A S L A E N V L V V V A V T C N S P M Y Y F I C S L A A F N T I A S L T K T C E N L M I T F A D V G G P S E T K L D D V M D C L L C M S F L G S I S S F L A I A V D R Y I T I F H T M Q R T R A I L G V I W I T C G M S A I S M V T F F S T F I M I C F V S F F I I S L V I I C F L Y V Y M F M L A R I H A R K I A S M R G A L T L T I L F G A F M V C W G P F F L H L I I I M V C N P Y C E C Y R S L F Q L H M V L L M S H A L I D P T I Y A F R S P E F K K C L R E T I S Y G
Pick color:
 
 
 
 
 
 
 
 
 
 
 
 




Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

V N E A L S A L G I T F F L F I P 1 C S L A A F N T I A S L T K T C E N L M 2 A L F S S I S G L F S M C L L C D M V D 3 T R A I L G V I W I T C G M S A I S M V 4 Y L F C I I V L S I I F F S V F C I M I 5 T I L F G A F M V C W G P F F L H L I I 6 T P D I L A H S M L L V M H L Q F L S 7
Pick color:
 
 
 
 
 
 
 
 
 
 
 
 




Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available