MC2 receptor (a0a665tij4_echna)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC2 receptor

GENE

mc2r

ORGANISM

Live sharksucker (Echeneis naucrates)

ALT. NAMES

Adrenocorticotropic hormone receptor, Adrenocorticotropin receptor, Melanocortin receptor 2

SOURCE

TREMBL

SEQUENCE

N-term        
N
D
N
V
P
R
E
P
F
C
10
                   
Q
A
L
H
N
N
L
Q
T
P
20
                   
D
D
V
I
D
V
Y
A
V
V
30
          TM1    
V
L
M
L
I
S
F
L
T
H
40
                   
I
E
N
H
P
A
S
L
A
E
50
                   
N
V
L
V
V
V
A
V
T
C
60
  ICL1 TM2    
N
R
N
L
H
S
P
M
Y
Y
70
                   
F
I
C
S
L
A
A
F
N
T
80
                   
I
A
S
L
T
K
T
C
E
N
90
                   
L
M
I
T
F
A
D
V
G
H
100
ECL1 TM3      
L
E
K
K
G
P
S
E
T
K
110
                   
L
D
D
V
M
D
C
L
L
C
120
                   
M
S
F
L
G
S
I
S
S
F
130
                   
L
A
I
A
V
D
R
Y
I
T
140
      ICL2      
I
F
H
A
L
R
Y
H
N
I
150
  TM4            
M
T
M
Q
R
T
R
A
I
L
160
                   
G
V
I
W
I
T
C
G
M
S
170
                   
A
I
S
M
V
T
F
F
A
S
180
TM5              
T
F
I
M
I
C
F
V
S
F
190
                   
F
I
I
S
L
V
I
I
C
F
200
                   
L
Y
V
Y
M
F
M
L
A
R
210
                   
I
H
A
R
K
I
A
A
L
P
220
ICL3            
S
S
G
G
R
N
C
H
H
Q
230
          TM6    
Q
R
W
G
S
S
M
R
G
A
240
                   
L
T
L
T
I
L
F
G
A
F
250
                   
M
V
C
W
G
P
F
F
L
H
260
                   
L
I
I
I
M
V
C
P
T
N
270
TM7              
P
Y
C
E
C
Y
R
S
L
F
280
                   
Q
L
H
M
V
L
L
M
S
H
290
                   
A
L
I
D
P
T
I
Y
A
F
300
  H8              
R
S
P
E
L
R
E
T
F
K
310
                   
K
M
L
V
C
S
F
I
L
F
320
C-term  
R
E
W
I
C
I
C

LINKS

DIAGRAMS

7TM

ICL1 R N L H ICL1ECL1 H L E K K ECL1ICL2 A L R Y H N I M ICL2ECL2 A ECL2ICL3 A L P S S G G R N C H H Q Q R W G S ICL3ECL3 P T ECL3N-term N D N V P R E P F C Q A L H N N L Q T P D D V I D V Y A V V V L M L I N-termC-term F I L F R E W I C I C C-term S F L T H I E N H P A S L A E N V L V V V A V T C N S P M Y Y F I C S L A A F N T I A S L T K T C E N L M I T F A D V G G P S E T K L D D V M D C L L C M S F L G S I S S F L A I A V D R Y I T I F H T M Q R T R A I L G V I W I T C G M S A I S M V T F F S T F I M I C F V S F F I I S L V I I C F L Y V Y M F M L A R I H A R K I A S M R G A L T L T I L F G A F M V C W G P F F L H L I I I M V C N P Y C E C Y R S L F Q L H M V L L M S H A L I D P T I Y A F R S P E F K K S L R E T M L V C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

V N E A L S A P H N E I H T L F S 1 C S L A A F N T I A S L T K T C E N L M 2 A L F S S I S G L F S M C L L C D M V D 3 T R A I L G V I W I T C G M S A I S M V 4 Y L F C I I V L S I I F F S V F C I M I 5 T I L F G A F M V C W G P F F L H L I I 6 T P D I L A H S M L L V M H L Q F L S 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available