MC2 receptor (a0a665tsd5_echna)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC2 receptor

GENE

mc2r

ORGANISM

Live sharksucker (Echeneis naucrates)

ALT. NAMES

Adrenocorticotropic hormone receptor, Adrenocorticotropin receptor, Melanocortin receptor 2

SOURCE

TREMBL

SEQUENCE

N-term        
N
E
L
L
D
K
R
F
L
D
10
                   
V
N
Q
L
F
N
P
H
R
E
20
                   
P
P
W
Q
T
M
N
T
T
L
30
                   
V
T
Q
S
D
C
P
D
V
K
40
  TM1            
V
P
I
F
L
F
F
T
I
G
50
                   
L
A
S
L
A
E
N
V
L
V
60
                   
V
V
A
V
T
C
N
R
N
L
70
ICL1 TM2      
H
S
P
M
Y
Y
F
I
C
S
80
                   
L
A
A
F
N
T
I
A
S
L
90
                   
T
K
T
C
E
N
L
M
I
T
100
          ECL1  
F
A
D
V
G
H
L
E
K
K
110
TM3              
G
P
S
E
T
K
L
D
D
V
120
                   
M
D
C
L
L
C
M
S
F
L
130
                   
G
S
I
S
S
F
L
A
I
A
140
                   
V
D
R
Y
I
T
I
F
H
A
150
ICL2       TM4
L
R
Y
H
N
I
M
T
M
Q
160
                   
R
T
R
A
I
L
G
V
I
W
170
                   
I
T
C
G
M
S
A
I
S
M
180
        ECL2 TM5
V
T
F
F
A
S
T
F
I
M
190
                 
I
C
F
V
S
F
F
I
I
S
200
                   
L
V
I
I
C
F
L
Y
V
Y
210
                   
M
F
M
L
A
R
I
H
A
R
220
      ICL3      
K
I
A
A
L
P
S
S
G
G
230
                   
R
N
C
H
H
Q
Q
R
W
G
240
  TM6            
S
S
M
R
G
A
L
T
L
T
250
                   
I
L
F
G
A
F
M
V
C
W
260
                   
G
P
F
F
L
H
L
I
I
I
270
      ECL3 TM7
M
V
C
P
T
N
P
Y
C
E
280
                   
C
Y
R
S
L
F
Q
L
H
M
290
                   
V
L
L
M
S
H
A
L
I
D
300
              H8  
P
T
I
Y
A
F
R
S
P
E
310
                   
L
R
E
T
F
K
K
M
L
L
320
    C-term
F
A
N
W
K

LINKS

UniProt

DIAGRAMS

7TM

ICL1 R N L H ICL1ECL1 H L E K K ECL1ICL2 A L R Y H N I M ICL2ECL2 A ECL2ICL3 A L P S S G G R N C H H Q Q R W G S ICL3ECL3 P T ECL3N-term N E L L D K R F L D V N Q L F N P H R E P P W Q T M N T T L V T Q S D C P D V K V N-termC-term N W K C-term P I F L F F T I G L A S L A E N V L V V V A V T C N S P M Y Y F I C S L A A F N T I A S L T K T C E N L M I T F A D V G G P S E T K L D D V M D C L L C M S F L G S I S S F L A I A V D R Y I T I F H T M Q R T R A I L G V I W I T C G M S A I S M V T F F S T F I M I C F V S F F I I S L V I I C F L Y V Y M F M L A R I H A R K I A S M R G A L T L T I L F G A F M V C W G P F F L H L I I I M V C N P Y C E C Y R S L F Q L H M V L L M S H A L I D P T I Y A F R S P E F K K A L R E T M L L F
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

V N E A L S A L G I T F F L F I P 1 C S L A A F N T I A S L T K T C E N L M 2 A L F S S I S G L F S M C L L C D M V D 3 T R A I L G V I W I T C G M S A I S M V 4 Y L F C I I V L S I I F F S V F C I M I 5 T I L F G A F M V C W G P F F L H L I I 6 T P D I L A H S M L L V M H L Q F L S 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available