MC2 receptor (a0a667znt3_9tele)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC2 receptor

GENE

mc2r

ORGANISM

pinecone soldierfish (Myripristis murdjan)

ALT. NAMES

Adrenocorticotropic hormone receptor, Adrenocorticotropin receptor, Melanocortin receptor 2

SOURCE

TREMBL

SEQUENCE

N-term        
M
N
A
T
T
A
S
T
T
A
10
                   
L
M
V
N
Q
S
D
C
P
E
20
      TM1        
V
E
V
P
V
P
L
F
F
T
30
                   
I
G
V
V
G
L
A
E
N
F
40
                   
L
V
V
V
A
V
I
C
N
R
50
ICL1 TM2      
N
L
H
S
P
M
Y
C
F
I
60
                   
C
S
L
A
A
F
N
T
I
A
70
                   
S
L
A
K
T
W
E
N
L
M
80
                   
L
V
F
A
G
V
G
Q
L
D
90
ECL1 TM3      
Q
R
G
S
S
E
T
K
L
D
100
                   
D
V
M
D
S
L
L
C
M
S
110
                   
F
V
G
S
I
F
S
F
M
A
120
                   
I
A
V
D
R
Y
I
T
I
F
130
  ICL2          
H
A
L
R
Y
H
N
I
M
T
140
TM4              
M
R
R
T
A
A
I
L
G
V
150
                   
I
W
T
T
C
G
V
L
A
M
160
            ECL2 TM5
L
M
V
R
F
F
D
T
I
F
170
             
I
M
T
C
F
I
I
F
F
L
180
                   
I
S
L
V
L
I
G
C
L
Y
190
                   
V
Y
M
F
M
L
A
R
I
H
200
          ICL3  
A
R
R
I
A
A
L
P
T
S
210
                   
G
S
G
R
G
R
W
R
R
Q
220
          TM6    
R
W
R
G
G
T
M
R
G
A
230
                   
L
T
L
T
I
L
F
G
A
F
240
                   
V
V
C
W
A
P
F
F
L
H
250
                   
L
I
I
I
M
V
C
P
L
N
260
TM7              
P
Y
C
E
C
Y
R
S
L
F
270
                   
Q
L
H
V
V
L
L
M
S
H
280
                   
A
L
I
D
P
A
I
Y
A
F
290
  H8              
R
S
A
E
L
R
H
T
F
R
300
                 
K
M
L
L
C
S
D
W
R

LINKS

UniProt

DIAGRAMS

7TM

ICL1 R N L H ICL1ECL1 Q L D Q R ECL1ICL2 A L R Y H N I M ICL2ECL2 D ECL2ICL3 A L P T S G S G R G R W R R Q R W R G G ICL3ECL3 P L ECL3N-term M N A T T A S T T A L M V N Q S D C P E V E V N-termC-term D W R C-term P V P L F F T I G V V G L A E N F L V V V A V I C N S P M Y C F I C S L A A F N T I A S L A K T W E N L M L V F A G V G G S S E T K L D D V M D S L L C M S F V G S I F S F M A I A V D R Y I T I F H T M R R T A A I L G V I W T T C G V L A M L M V R F F T I F I M T C F I I F F L I S L V L I G C L Y V Y M F M L A R I H A R R I A T M R G A L T L T I L F G A F V V C W A P F F L H L I I I M V C N P Y C E C Y R S L F Q L H V V L L M S H A L I D P A I Y A F R S A E F R K S L R H T M L L C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

F N E A L G V V G I T F F L P V P 1 C S L A A F N T I A S L A K T W E N L M 2 A M F S F I S G V F S M C L L S D M V D 3 T A A I L G V I W T T C G V L A M L M V 4 Y L C G I L V L S I L F F I I F C T M I 5 T I L F G A F V V C W A P F F L H L I I 6 A P D I L A H S M L L V V H L Q F L S 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available