MC2 receptor (a0a6i9hl93_geofo)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC2 receptor

GENE

MC2R ()

ORGANISM

Medium ground-finch (Geospiza fortis)

ALT. NAMES

Adrenocorticotropic hormone receptor, Adrenocorticotropin receptor, Melanocortin receptor 2

SOURCE

TREMBL

SEQUENCE

N-term        
M
T
R
R
M
S
T
E
R
P
10
                   
S
N
L
I
K
H
P
G
Q
T
20
                   
S
I
P
S
L
E
N
I
S
D
30
                   
F
S
L
N
I
T
D
C
T
Q
40
      TM1        
V
V
V
P
E
E
V
F
F
T
50
                   
V
A
A
A
G
I
L
E
N
L
60
                   
L
I
L
I
A
V
V
R
N
K
70
ICL1 TM2      
N
L
H
L
P
M
Y
F
F
I
80
                   
C
S
L
A
I
S
D
M
L
G
90
                   
S
L
Y
K
T
L
E
N
I
F
100
                   
I
I
L
C
K
M
G
Y
L
T
110
ECL1 TM3      
R
H
G
D
F
E
K
K
L
D
120
                   
D
A
M
D
S
M
F
I
L
S
130
                   
L
L
G
S
I
F
S
L
L
A
140
                   
I
A
A
D
R
Y
I
T
I
F
150
  ICL2          
Y
A
L
R
Y
H
N
I
M
T
160
TM4              
L
R
R
A
L
V
I
L
A
I
170
                   
I
W
A
F
C
A
G
S
S
I
180
            ECL2 TM5
A
I
A
L
F
S
Y
E
A
A
190
             
T
V
I
P
F
T
I
L
F
P
200
                   
L
M
M
F
F
I
F
C
L
Y
210
                   
V
H
M
F
L
L
A
R
S
H
220
          ICL3  
A
K
K
I
A
S
L
P
S
S
230
            TM6  
T
V
H
H
R
T
N
T
K
G
240
                   
A
I
T
L
T
I
F
L
G
V
250
                   
F
L
C
C
W
A
P
F
V
L
260
                   
H
I
L
L
A
R
F
C
P
H
270
TM7              
N
P
Y
C
A
C
Y
M
S
I
280
                   
F
H
V
N
G
T
L
I
M
C
290
                   
N
A
I
I
N
P
M
I
F
A
300
    H8            
F
R
S
P
E
L
R
S
T
F
310
                   
K
K
M
F
Y
C
P
R
S
S
320
C-term
C
N
W

LINKS

UniProt

DIAGRAMS

7TM

ICL1 K N L H ICL1ECL1 Y L T R H ECL1ICL2 A L R Y H N I M ICL2ECL2 Y ECL2ICL3 S L P S S T V H H R T ICL3ECL3 P H ECL3N-term M T R R M S T E R P S N L I K H P G Q T S I P S L E N I S D F S L N I T D C T Q V V V N-termC-term R S S C N W C-term P E E V F F T V A A A G I L E N L L I L I A V V R N L P M Y F F I C S L A I S D M L G S L Y K T L E N I F I I L C K M G G D F E K K L D D A M D S M F I L S L L G S I F S L L A I A A D R Y I T I F Y T L R R A L V I L A I I W A F C A G S S I A I A L F S E A A T V I P F T I L F P L M M F F I F C L Y V H M F L L A R S H A K K I A N T K G A I T L T I F L G V F L C C W A P F V L H I L L A R F C N P Y C A C Y M S I F H V N G T L I M C N A I I N P M I F A F R S P E F K K P L R S T M F Y C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N E L I G A A A V T F F V E E P 1 C S L A I S D M L G S L Y K T L E N I F 2 A L L S F I S G L L S L I F M S D M A D 3 A L V I L A I I W A F C A G S S I A I A 4 Y L C F I F F M M L P F L I T F P I V T 5 T I F L G V F L C C W A P F V L H I L L 6 M P N I I A N C M I L T G N V H F I S 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available