MC2 receptor (a0a6j0til0_9saur)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC2 receptor

GENE

MC2R

ORGANISM

central bearded dragon (Pogona vitticeps)

ALT. NAMES

Adrenocorticotropic hormone receptor, Adrenocorticotropin receptor, Melanocortin receptor 2

SOURCE

TREMBL

SEQUENCE

N-term        
M
N
N
P
L
E
N
N
S
E
10
                   
L
S
V
N
I
S
D
C
P
E
20
      TM1        
V
A
I
P
N
E
I
F
F
S
30
                   
I
A
T
L
G
I
L
E
N
L
40
                   
L
V
L
I
A
V
G
R
N
K
50
ICL1 TM2      
N
L
H
S
P
M
Y
F
F
I
60
                   
C
S
L
A
I
S
D
M
L
G
70
                   
S
F
Y
K
A
V
E
N
I
F
80
                   
F
T
V
F
C
T
V
R
Y
P
90
ECL1 TM3      
K
C
Q
E
L
L
A
Q
T
M
100
                   
D
D
I
I
D
F
M
F
I
L
110
                   
S
L
L
G
S
I
F
S
L
S
120
                   
A
I
A
A
D
R
Y
I
T
I
130
    ICL2        
F
Y
A
L
Q
Y
H
N
I
M
140
TM4              
T
L
K
R
A
F
V
I
L
V
150
                   
A
I
W
A
V
S
A
G
S
G
160
                   
I
A
M
V
I
F
S
Y
K
T
170
TM5              
V
T
I
V
S
F
T
V
L
F
180
                   
C
F
M
F
I
F
I
L
C
L
190
                   
Y
I
H
M
F
L
L
A
R
S
200
            ICL3
H
A
K
A
I
A
L
M
T
T
210
              TM6
N
S
V
R
Q
G
A
N
M
K
220
                   
G
V
I
T
L
T
V
L
L
G
230
                   
V
F
L
C
C
W
A
P
F
V
240
                   
L
H
M
I
L
I
H
F
C
P
250
ECL3 TM7      
Q
N
P
Y
C
I
C
Y
L
S
260
                   
I
F
Q
V
N
G
M
L
I
M
270
                   
C
N
S
M
I
D
P
M
I
Y
280
      H8          
A
F
R
S
P
E
L
R
S
T
290
                   
F
R
K
V
F
C
F
H
N
P
300
C-term
S
W
T

LINKS

UniProt

DIAGRAMS

7TM

ICL1 K N L H ICL1ECL1 R Y P K C Q ECL1ICL2 A L Q Y H N I M ICL2ECL2 Y ECL2ICL3 L M T T N S V R Q G A ICL3ECL3 P Q ECL3N-term M N N P L E N N S E L S V N I S D C P E V A I N-termC-term N P S W T C-term P N E I F F S I A T L G I L E N L L V L I A V G R N S P M Y F F I C S L A I S D M L G S F Y K A V E N I F F T V F C T V E L L A Q T M D D I I D F M F I L S L L G S I F S L S A I A A D R Y I T I F Y T L K R A F V I L V A I W A V S A G S G I A M V I F S K T V T I V S F T V L F C F M F I F I L C L Y I H M F L L A R S H A K A I A N M K G V I T L T V L L G V F L C C W A P F V L H M I L I H F C N P Y C I C Y L S I F Q V N G M L I M C N S M I D P M I Y A F R S P E F R K H L R S T V F C F
Pick color:
 
 
 
 
 
 
 
 
 
 
 
 




Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N E L I G L T A I S F F I E N P 1 C S L A I S D M L G S F Y K A V E N I F 2 A S L S F I S G L L S L I F M F D I I D 3 A F V I L V A I W A V S A G S G I A M V 4 Y L C L I F I F M F C F L V T F S V I T 5 T V L L G V F L C C W A P F V L H M I L 6 M P D I M S N C M I L M G N V Q F I S 7
Pick color:
 
 
 
 
 
 
 
 
 
 
 
 




Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available