D4 receptor (drd4_mouse)

FAMILY

Class A (Rhodopsin) Aminergic receptors Dopamine receptors D4 receptor

GENE

Drd4

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

D(4) dopamine receptor, D(2C) dopamine receptor, Dopamine D4 receptor

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
G
N
S
S
A
T
E
D
G
10
                   
G
L
L
A
G
R
G
P
E
S
20
              TM1
L
G
T
G
A
G
L
G
G
A
30
                   
G
A
A
A
L
V
G
G
V
L
40
                   
L
I
G
L
V
L
A
G
N
S
50
                   
L
V
C
V
S
V
A
S
E
R
60
ICL1 TM2      
T
L
Q
T
P
T
N
Y
F
I
70
                   
V
S
L
A
A
A
D
L
L
L
80
                   
A
V
L
V
L
P
L
F
V
Y
90
          ECL1  
S
E
V
Q
G
G
V
W
L
L
100
TM3              
S
P
R
L
C
D
T
L
M
A
110
                   
M
D
V
M
L
C
T
A
S
I
120
                   
F
N
L
C
A
I
S
V
D
R
130
            ICL2
F
V
A
V
T
V
P
L
R
Y
140
TM4              
N
Q
Q
G
Q
C
Q
L
L
L
150
                   
I
A
A
T
W
L
L
S
A
A
160
                   
V
A
S
P
V
V
C
G
L
N
170
ECL2            
D
V
P
G
R
D
P
A
V
C
180
      TM5        
C
L
E
N
R
D
Y
V
V
Y
190
                   
S
S
V
C
S
F
F
L
P
C
200
                   
P
L
M
L
L
L
Y
W
A
T
210
                   
F
R
G
L
R
R
W
E
A
A
220
          ICL3  
R
H
T
K
L
H
S
R
A
P
230
                   
R
R
P
S
G
P
G
P
P
V
240
                   
S
D
P
T
Q
G
P
F
F
P
250
                   
D
C
P
P
P
L
P
S
L
R
260
                   
T
S
P
S
D
S
S
R
P
E
270
                   
S
E
L
S
Q
R
P
C
S
P
280
                   
G
C
L
L
A
D
A
A
L
P
290
                   
Q
P
P
E
P
S
S
R
R
R
300
    TM6          
R
G
A
K
I
T
G
R
E
R
310
                   
K
A
M
R
V
L
P
V
V
V
320
                   
G
A
F
L
V
C
W
T
P
F
330
                   
F
V
V
H
I
T
R
A
L
C
340
ECL3   TM7    
P
A
C
F
V
S
P
R
L
V
350
                   
S
A
V
T
W
L
G
Y
V
N
360
                   
S
A
L
N
P
I
I
Y
T
I
370
  H8              
F
N
A
E
F
R
S
V
F
R
380
        C-term
K
T
L
R
L
R
C

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 R T L Q ICL1ECL1 G V W L L ECL1ICL2 P L R Y ICL2ECL2 L N D V P G R D P A V C C L E ECL2ICL3 H S R A P R R P S G P G P P V S D P T Q G P F F P D C P P P L P S L R T S P S D S S R P E S E L S Q R P C S P G C L L A D A A L P Q P P E P S S R R R R G ICL3ECL3 P A C F V ECL3N-term M G N S S A T E D G G L L A G R G P E S L G T G A G L N-termC-term L R C C-term G G A G A A A L V G G V L L I G L V L A G N S L V C V S V A S E T P T N Y F I V S L A A A D L L L A V L V L P L F V Y S E V Q G S P R L C D T L M A M D V M L C T A S I F N L C A I S V D R F V A V T V N Q Q G Q C Q L L L I A A T W L L S A A V A S P V V C G N R D Y V V Y S S V C S F F L P C P L M L L L Y W A T F R G L R R W E A A R H T K L A K I T G R E R K A M R V L P V V V G A F L V C W T P F F V V H I T R A L C S P R L V S A V T W L G Y V N S A L N P I I Y T I F N A E F R K F R S V T L R
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

S N G A L V L G I L L V G G V L A A A G 1 V S L A A A D L L L A L V V L P L F V Y S 2 A C L N F I S A T C L M V D M A M L T D 3 Q L L L I A A T W L L S A A V A S P V 4 Y L L L M L P C P L F F S C V S S Y V V Y 5 P V V V G A F L V C W T P F F V V H I T 6 I P N L A S N V Y G L W T V A S V L R 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models have been generated as experimental structures are available (see below).

STRUCTURES

Found 1 structure(s) - view all details on the Structures page

PDBs: 6IQL