MC2 receptor (g1kn89_anoca)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC2 receptor

GENE

MC2R

ORGANISM

Green anole (Anolis carolinensis)

ALT. NAMES

Adrenocorticotropic hormone receptor, Adrenocorticotropin receptor, Melanocortin receptor 2

SOURCE

TREMBL

SEQUENCE

N-term        
M
K
L
C
S
C
L
L
G
N
10
                   
S
T
Q
V
Q
P
N
K
C
G
20
                   
I
Q
L
Q
L
S
M
S
N
F
30
                   
S
V
N
T
S
D
C
A
P
V
40
    TM1          
V
V
P
E
E
I
F
F
I
I
50
                   
A
T
L
G
L
L
E
N
L
L
60
                   
V
L
I
A
V
G
R
N
K
N
70
ICL1 TM2      
L
H
S
P
M
Y
I
F
I
C
80
                   
S
L
A
V
S
D
M
L
G
S
90
                   
L
Y
K
A
V
E
N
I
F
Y
100
            ECL1
I
I
F
C
K
M
Q
Y
V
K
110
    TM3          
C
R
G
K
L
A
K
T
M
D
120
                   
D
I
L
D
F
M
F
I
L
S
130
                   
L
L
G
S
I
F
S
L
S
A
140
                   
I
A
A
D
R
Y
I
T
I
F
150
  ICL2          
Y
A
L
R
Y
H
N
I
M
T
160
TM4              
L
K
R
A
L
V
M
L
G
V
170
                   
I
W
A
F
C
T
G
S
G
I
180
            ECL2 TM5
A
M
V
L
F
S
Y
E
A
V
190
             
T
V
V
S
F
T
V
L
F
C
200
                   
F
M
L
I
L
I
L
C
L
Y
210
                   
I
H
M
F
L
L
A
R
S
H
220
          ICL3  
A
K
K
I
A
L
M
T
T
S
230
            TM6  
S
V
H
Q
G
A
N
M
K
G
240
                   
A
I
T
L
T
V
L
V
A
V
250
                   
F
L
F
C
W
S
P
F
V
L
260
                   
H
M
L
L
M
T
F
C
P
Q
270
TM7              
N
P
Y
C
I
C
Y
G
S
I
280
                   
F
H
V
H
G
M
L
I
M
C
290
                   
N
A
V
I
D
P
M
I
Y
A
300
    H8            
F
R
S
P
E
L
R
S
T
F
310
                   
R
R
L
F
C
C
H
K
P
N
320
C-term
W
T

LINKS

UniProt

DIAGRAMS

7TM

ICL1 K N L H ICL1ECL1 Q Y V K C R ECL1ICL2 A L R Y H N I M ICL2ECL2 Y ECL2ICL3 L M T T S S V H Q G A ICL3ECL3 P Q ECL3N-term M K L C S C L L G N S T Q V Q P N K C G I Q L Q L S M S N F S V N T S D C A P V V V N-termC-term K P N W T C-term P E E I F F I I A T L G L L E N L L V L I A V G R N S P M Y I F I C S L A V S D M L G S L Y K A V E N I F Y I I F C K M G K L A K T M D D I L D F M F I L S L L G S I F S L S A I A A D R Y I T I F Y T L K R A L V M L G V I W A F C T G S G I A M V L F S E A V T V V S F T V L F C F M L I L I L C L Y I H M F L L A R S H A K K I A N M K G A I T L T V L V A V F L F C W S P F V L H M L L M T F C N P Y C I C Y G S I F H V H G M L I M C N A V I D P M I Y A F R S P E F R R H L R S T L F C C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N E L L G L T A I I F F I E E P 1 C S L A V S D M L G S L Y K A V E N I F 2 A S L S F I S G L L S L I F M F D L I D 3 A L V M L G V I W A F C T G S G I A M V 4 Y L C L I L I L M F C F L V T F S V V T 5 T V L V A V F L F C W S P F V L H M L L 6 M P D I V A N C M I L M G H V H F I S 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available