MC2 receptor (r7vva3_colli)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC2 receptor

GENE

MC2R (A306_00001626)

ORGANISM

Rock dove (Columba livia)

ALT. NAMES

Adrenocorticotropic hormone receptor, Adrenocorticotropin receptor, Melanocortin receptor 2

SOURCE

TREMBL

SEQUENCE

N-term        
M
S
T
E
R
P
P
S
L
I
10
                   
K
H
A
G
Q
T
S
V
T
S
20
                   
L
E
N
I
S
D
F
S
L
N
30
                   
V
T
D
C
T
Q
V
V
V
P
40
TM1              
E
E
V
F
F
T
V
A
A
A
50
                   
G
I
L
E
N
L
L
V
L
I
60
          ICL1  
A
V
V
R
N
K
N
L
H
L
70
TM2              
P
M
Y
F
F
I
C
S
L
A
80
                   
V
S
D
M
L
G
S
L
Y
K
90
                   
T
L
E
N
I
F
I
I
L
C
100
      ECL1      
K
I
G
Y
L
T
P
R
G
D
110
TM3              
F
E
K
K
L
D
D
A
M
D
120
                   
S
M
F
I
L
S
L
L
G
S
130
                   
I
F
S
L
L
A
I
A
A
D
140
                   
R
Y
I
T
I
F
Y
A
L
R
150
ICL2   TM4    
Y
H
N
I
M
T
L
R
R
A
160
                   
L
V
I
L
A
I
I
W
T
F
170
                   
C
A
G
S
S
I
A
I
A
L
180
    ECL2 TM5  
F
S
Y
E
A
A
T
V
I
P
190
                   
F
T
I
L
F
P
L
M
M
F
200
                   
F
I
L
C
L
Y
V
H
M
F
210
                   
L
L
A
R
S
H
A
K
K
I
220
  ICL3          
A
S
L
P
T
S
T
V
H
Q
230
    TM6          
R
T
N
M
K
G
A
I
T
L
240
                   
T
I
F
L
G
V
F
L
C
C
250
                   
W
A
P
F
V
L
H
I
L
L
260
        ECL3 TM7
A
R
F
C
P
H
N
P
Y
C
270
                 
A
C
Y
M
S
I
F
H
V
N
280
                   
G
T
L
I
M
C
N
A
I
I
290
                H8
D
P
M
I
F
A
F
R
S
P
300
                   
E
L
R
S
T
F
K
K
M
F
310
      C-term
C
C
A
R
S
N
W
N
W

LINKS

UniProt

DIAGRAMS

7TM

ICL1 K N L H ICL1ECL1 Y L T P R ECL1ICL2 A L R Y H N I M ICL2ECL2 Y ECL2ICL3 S L P T S T V H Q R T ICL3ECL3 P H ECL3N-term M S T E R P P S L I K H A G Q T S V T S L E N I S D F S L N V T D C T Q V V V N-termC-term R S N W N W C-term P E E V F F T V A A A G I L E N L L V L I A V V R N L P M Y F F I C S L A V S D M L G S L Y K T L E N I F I I L C K I G G D F E K K L D D A M D S M F I L S L L G S I F S L L A I A A D R Y I T I F Y T L R R A L V I L A I I W T F C A G S S I A I A L F S E A A T V I P F T I L F P L M M F F I L C L Y V H M F L L A R S H A K K I A N M K G A I T L T I F L G V F L C C W A P F V L H I L L A R F C N P Y C A C Y M S I F H V N G T L I M C N A I I D P M I F A F R S P E F K K A L R S T M F C C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N E L I G A A A V T F F V E E P 1 C S L A V S D M L G S L Y K T L E N I F 2 A L L S F I S G L L S L I F M S D M A D 3 A L V I L A I I W T F C A G S S I A I A 4 Y L C L I F F M M L P F L I T F P I V T 5 T I F L G V F L C C W A P F V L H I L L 6 M P D I I A N C M I L T G N V H F I S 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available