S1P4 receptor (s1pr4_mouse)

FAMILY

Class A (Rhodopsin) Lipid receptors Lysophospholipid (S1P) receptors S1P4 receptor

GENE

S1pr4 (Edg6, Lpc1, S1p4)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Sphingosine 1-phosphate receptor 4, S1P receptor 4, S1P4, Endothelial differentiation G-protein coupled receptor 6, Lysophospholipid receptor C1, Sphingosine 1-phosphate receptor Edg-6, S1P receptor Edg-6

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
N
I
S
T
W
S
T
L
V
10
                   
T
P
E
S
C
H
R
L
A
A
20
                   
S
G
H
S
L
L
I
V
L
H
30
                   
Y
N
H
S
G
R
L
A
S
R
40
          TM1    
G
G
S
E
D
G
G
G
L
G
50
                   
M
L
R
G
P
S
V
A
A
G
60
                   
C
L
V
V
L
E
N
A
M
V
70
                   
L
A
A
I
A
I
Y
M
R
S
80
ICL1 TM2      
R
R
W
V
Y
Y
C
L
L
N
90
                   
I
T
L
S
D
L
L
T
G
L
100
                   
A
Y
V
V
N
V
L
L
S
G
110
ECL1     TM3  
T
R
T
F
Q
L
S
P
V
H
120
                   
W
F
L
R
E
G
L
L
F
M
130
                   
A
L
A
A
S
T
F
S
L
L
140
                   
F
T
A
G
E
R
F
A
T
M
150
    ICL2        
V
R
V
A
E
S
G
A
T
K
160
TM4              
T
S
R
V
Y
G
C
I
G
L
170
                   
C
W
L
L
A
A
I
L
G
L
180
          ECL2  
L
P
L
L
G
W
N
C
V
C
190
                   
A
F
P
R
C
S
S
L
L
P
200
    TM5          
L
Y
S
K
G
Y
V
L
F
C
210
                   
V
V
V
F
A
L
I
L
V
A
220
                   
I
L
S
L
Y
G
A
I
F
R
230
          ICL3  
V
V
R
A
N
G
Q
K
S
P
240
TM6              
R
P
P
A
R
R
K
S
R
R
250
                   
L
L
N
T
V
L
M
I
L
V
260
                   
A
F
V
V
C
W
G
P
L
F
270
                   
G
L
L
L
A
D
I
F
G
S
280
ECL3   TM7    
N
V
W
A
Q
E
Y
L
R
G
290
                   
M
D
W
I
L
A
L
A
V
F
300
                   
N
S
A
I
N
P
L
I
Y
S
310
    H8            
F
R
S
R
E
V
Q
R
A
V
320
                   
L
A
F
L
C
C
G
C
L
W
330
C-term        
L
G
L
R
G
P
G
D
C
L
340
                   
T
R
I
T
E
A
H
S
G
A
350
                   
S
T
T
D
S
S
L
R
P
R
360
                   
D
S
F
R
T
S
R
S
L
S
370
                   
F
R
M
R
E
P
L
S
S
I
380
           
S
S
V
R
S
T

LINKS

DIAGRAMS

A N E L V V L C G A A V S P G R L M G L 1 L N I T L S D L L T G L A Y V V N V L L 2 F L L S F T S A A L A M F L L G E R L F 3 V Y G C I G L C W L L A A I L G L L P L 4 Y L S L I A V L I L A F V V V C F L V Y 5 L M I L V A F V V C W G P L F G L L L A 6 L P N I A S N F V A L A L I W D M G R 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

ICL1 M R S R ICL1ECL1 G T R T F Q L ECL1ICL2 V A E S G A T ICL2ECL2 W N C V C A F P R C S S L L P L Y ECL2ICL3 G Q K S P ICL3ECL3 S N V W A Q ECL3N-term M N I S T W S T L V T P E S C H R L A A S G H S L L I V L H Y N H S G R L A S R G G S E D N-termC-term C G C L W L G L R G P G D C L T R I T E A H S G A S T T D S S L R P R D S F R T S R S L S F R M R E P L S S I S S V R S T C-term G G G L G M L R G P S V A A G C L V V L E N A M V L A A I A I Y R W V Y Y C L L N I T L S D L L T G L A Y V V N V L L S S P V H W F L R E G L L F M A L A A S T F S L L F T A G E R F A T M V R K T S R V Y G C I G L C W L L A A I L G L L P L L G S K G Y V L F C V V V F A L I L V A I L S L Y G A I F R V V R A N R P P A R R K S R R L L N T V L M I L V A F V V C W G P L F G L L L A D I F G E Y L R G M D W I L A L A V F N S A I N P L I Y S F R S R E V L A V Q R A F L C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

ENDOGENOUS LIGANDS

sphingosine 1-phosphate

HOMOLOGY MODELS

No homology models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available