succinate receptor (sucr1_rat)

FAMILY

Class A (Rhodopsin) Alicarboxylic acid receptors Succinate receptors succinate receptor

GENE

Sucnr1 (Gpr91)

ORGANISM

Rat (Rattus norvegicus)

ALT. NAMES

Succinate receptor 1, G-protein coupled receptor 91

SOURCE

SWISSPROT

SEQUENCE

N-term TM1  
M
A
Q
N
L
S
C
E
N
W
10
                   
L
A
L
E
N
I
L
K
K
Y
20
                   
Y
L
S
A
F
Y
G
I
E
F
30
                   
I
V
G
M
L
G
N
F
T
V
40
                   
V
F
G
Y
L
F
C
M
K
N
50
ICL1 TM2      
W
N
S
S
N
V
Y
L
F
N
60
                   
L
S
I
S
D
L
A
F
L
C
70
                   
T
L
P
M
L
I
R
S
Y
A
80
    ECL1 TM3  
T
G
N
W
T
Y
G
D
V
L
90
                   
C
I
S
N
R
Y
V
L
H
A
100
                   
N
L
Y
T
S
I
L
F
L
T
110
                   
F
I
S
I
D
R
Y
L
L
M
120
    ICL2        
K
F
P
F
R
E
H
I
L
Q
130
TM4              
K
K
E
F
A
I
L
I
S
L
140
                   
A
V
W
V
L
V
T
L
E
V
150
                   
L
P
M
L
T
F
I
T
S
T
160
ECL2            
P
I
E
K
G
D
S
C
V
D
170
          TM5    
Y
A
S
S
G
N
P
K
Y
S
180
                   
L
I
Y
S
L
C
L
T
L
L
190
                   
G
F
L
I
P
L
S
V
M
C
200
                   
F
F
Y
Y
K
M
V
V
F
L
210
      ICL3 TM6
K
K
R
S
Q
Q
Q
A
T
V
220
                   
L
S
L
N
K
P
L
R
L
V
230
                   
V
L
A
V
V
I
F
S
V
L
240
                   
F
T
P
Y
H
I
M
R
N
V
250
            ECL3
R
I
A
S
R
L
D
S
W
P
260
    TM7          
Q
G
C
S
Q
K
A
I
K
C
270
                   
L
Y
I
L
T
R
P
L
A
F
280
                   
L
N
S
A
V
N
P
I
F
Y
290
      H8          
F
L
V
G
D
H
F
R
D
M
300
                   
L
F
S
K
L
R
Q
Y
F
K
310
    C-term
S
L
T
S
F
R
L

LINKS

DIAGRAMS

7TM

ICL1 K N W ICL1ECL1 N W T Y ECL1ICL2 P F R E H I L Q ICL2ECL2 P I E K G D S C V D Y A S S G ECL2ICL3 S Q Q ICL3ECL3 D S W P Q G ECL3N-term M A Q N L S N-termC-term T S F R L C-term C E N W L A L E N I L K K Y Y L S A F Y G I E F I V G M L G N F T V V F G Y L F C M N S S N V Y L F N L S I S D L A F L C T L P M L I R S Y A T G G D V L C I S N R Y V L H A N L Y T S I L F L T F I S I D R Y L L M K F K K E F A I L I S L A V W V L V T L E V L P M L T F I T S T N P K Y S L I Y S L C L T L L G F L I P L S V M C F F Y Y K M V V F L K K R Q A T V L S L N K P L R L V V L A V V I F S V L F T P Y H I M R N V R I A S R L C S Q K A I K C L Y I L T R P L A F L N S A V N P I F Y F L V G D H L F S Y F K F R D M K L R Q S L
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

F N G L M G V I F E I G Y F A S L Y Y K 1 F N L S I S D L A F L C T L P M L I R S 2 F T L F L I S T Y L N A H L V Y R N S I 3 A I L I S L A V W V L V T L E V L P M 4 Y F F C M V S L P I L F G L L T L C L S Y 5 V L A V V I F S V L F T P Y H I M R N V 6 I P N V A S N L F A L P R T L I Y L C 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models have been generated as experimental structures are available (see below).

STRUCTURES

Found 3 structure(s) - view all details on the Structures page

PDBs: 6IBB, 6RNK, 6Z10