TAS2R19 (t2r19_human)

FAMILY

Class T (Taste 2) Sensory receptors Taste 2 receptors TAS2R19

GENE

TAS2R19 (TAS2R23, TAS2R48)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Taste receptor type 2 member 19, Taste receptor type 2 member 23, Taste receptor type 2 member 48, T2R48

SOURCE

SWISSPROT

SEQUENCE

N-term TM1  
M
M
C
F
L
L
I
I
S
S
10
                   
I
L
V
V
F
A
F
V
L
G
20
                   
N
V
A
N
G
F
I
A
L
V
30
                   
N
V
I
D
W
V
N
T
R
K
40
ICL1 TM2      
I
S
S
A
E
Q
I
L
T
A
50
                   
L
V
V
S
R
I
G
L
L
W
60
                   
V
M
L
F
L
W
Y
A
T
V
70
    ECL1 TM3  
F
N
S
A
L
Y
G
L
E
V
80
                   
R
I
V
A
S
N
A
W
A
V
90
                   
T
N
H
F
S
M
W
L
A
A
100
                   
S
L
S
I
F
C
L
L
K
I
110
  ICL2          
A
N
F
S
N
L
I
S
L
H
120
      TM4        
L
K
K
R
I
K
S
V
V
L
130
                   
V
I
L
L
G
P
L
V
F
L
140
                   
I
C
N
L
A
V
I
T
M
D
150
    ECL2        
E
R
V
W
T
K
E
Y
E
G
160
                   
N
V
T
W
K
I
K
L
R
N
170
          TM5    
A
I
H
L
S
S
L
T
V
T
180
                   
T
L
A
N
L
I
P
F
T
L
190
                   
S
L
I
C
F
L
L
L
I
C
200
                   
S
L
C
K
H
L
K
K
M
R
210
      ICL3 TM6
L
H
S
K
G
S
Q
D
P
S
220
                   
T
K
V
H
I
K
A
L
Q
T
230
                   
V
T
S
F
L
M
L
F
A
I
240
                   
Y
F
L
C
I
I
T
S
T
W
250
        ECL3 TM7
N
L
R
T
Q
Q
S
K
L
V
260
                 
L
L
L
C
Q
T
V
A
I
M
270
                   
Y
P
S
F
H
S
F
I
L
I
280
    H8            
M
G
S
R
K
L
K
Q
T
F
290
                 
L
S
V
L
W
Q
M
T
R

LINKS

BitterDB

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 K I ICL1ECL1 S A L Y ECL1ICL2 N F S N L I S L H L K K ICL2ECL2 V W T K E Y E G N V T W K I K L R N A I H L S ECL2ICL3 K G S Q ICL3ECL3 Q Q S ECL3N-term M N-term M C F L L I I S S I L V V F A F V L G N V A N G F I A L V N V I D W V N T R S S A E Q I L T A L V V S R I G L L W V M L F L W Y A T V F N G L E V R I V A S N A W A V T N H F S M W L A A S L S I F C L L K I A R I K S V V L V I L L G P L V F L I C N L A V I T M D E R S L T V T T L A N L I P F T L S L I C F L L L I C S L C K H L K K M R L H S D P S T K V H I K A L Q T V T S F L M L F A I Y F L C I I T S T W N L R T K L V L L L C Q T V A I M Y P S F H S F I L I M G S R K F L S M T R L K Q T V L W Q
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N A V N G L V F A F V V L I S S I I L 1 T A L V V S R I G L L W V M L F L W Y A 2 S A A L W M S F H N T V A W A N S A V I 3 V L V I L L G P L V F L I C N L A V I T 4 F C I L S L T F P I L N A L T T V T L S 5 V T S F L M L F A I Y F L C I I T S T W 6 F S H F S P Y M I A V T Q C L L L V L 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

t2r19_human active,

t2r19_human inactive

STRUCTURES

No structures available