TAS2R45 (t2r45_human)
FAMILY
Class T (Taste 2) Sensory receptors Taste 2 receptors TAS2R45
GENE
TAS2R45 (GPR59)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Taste receptor type 2 member 45, T2R45, G-protein coupled receptor 59
SOURCE
SWISSPROT
SEQUENCE
N-term | TM1 | ||||||||
M
|
I
|
T
|
F
|
L
|
P
|
I
|
I
|
F
|
S
|
10 |
I
|
L
|
V
|
V
|
V
|
T
|
F
|
V
|
I
|
G
|
20 |
N
|
F
|
A
|
N
|
G
|
F
|
I
|
A
|
L
|
V
|
30 |
N
|
S
|
T
|
E
|
W
|
V
|
K
|
R
|
Q
|
K
|
40 |
ICL1 | TM2 | ||||||||
I
|
S
|
F
|
A
|
D
|
Q
|
I
|
V
|
T
|
A
|
50 |
L
|
A
|
V
|
S
|
R
|
V
|
G
|
L
|
L
|
W
|
60 |
V
|
L
|
L
|
L
|
N
|
W
|
Y
|
S
|
T
|
V
|
70 |
ECL1 | TM3 | ||||||||
L
|
N
|
P
|
A
|
F
|
C
|
S
|
V
|
E
|
L
|
80 |
R
|
T
|
T
|
A
|
Y
|
N
|
I
|
W
|
A
|
V
|
90 |
T
|
G
|
H
|
F
|
S
|
N
|
W
|
P
|
A
|
T
|
100 |
S
|
L
|
S
|
I
|
F
|
Y
|
L
|
L
|
K
|
I
|
110 |
ICL2 | |||||||||
A
|
N
|
F
|
S
|
N
|
L
|
I
|
F
|
L
|
R
|
120 |
TM4 | |||||||||
L
|
K
|
R
|
R
|
V
|
K
|
S
|
V
|
I
|
L
|
130 |
V
|
V
|
L
|
L
|
G
|
P
|
L
|
L
|
F
|
L
|
140 |
A
|
C
|
H
|
L
|
F
|
V
|
V
|
N
|
M
|
N
|
150 |
ECL2 | |||||||||
Q
|
I
|
V
|
W
|
T
|
K
|
E
|
Y
|
E
|
G
|
160 |
N
|
M
|
T
|
W
|
K
|
I
|
K
|
L
|
R
|
R
|
170 |
TM5 | |||||||||
A
|
M
|
Y
|
L
|
S
|
D
|
T
|
T
|
V
|
T
|
180 |
M
|
L
|
A
|
N
|
L
|
V
|
P
|
F
|
T
|
V
|
190 |
T
|
L
|
I
|
S
|
F
|
L
|
L
|
L
|
V
|
C
|
200 |
S
|
L
|
C
|
K
|
H
|
L
|
K
|
K
|
M
|
Q
|
210 |
ICL3 | TM6 | ||||||||
L
|
H
|
G
|
K
|
G
|
S
|
Q
|
D
|
P
|
S
|
220 |
T
|
K
|
V
|
H
|
I
|
K
|
V
|
L
|
Q
|
T
|
230 |
V
|
I
|
S
|
F
|
F
|
L
|
L
|
R
|
A
|
I
|
240 |
Y
|
F
|
V
|
S
|
V
|
I
|
I
|
S
|
V
|
W
|
250 |
ECL3 | TM7 | |||||||||
S
|
F
|
K
|
N
|
L
|
E
|
N
|
K
|
P
|
V
|
|
260 |
F
|
M
|
F
|
C
|
Q
|
A
|
I
|
G
|
F
|
S
|
270 |
C
|
S
|
S
|
A
|
H
|
P
|
F
|
I
|
L
|
I
|
280 |
H8 | |||||||||
W
|
G
|
N
|
K
|
K
|
L
|
K
|
Q
|
T
|
Y
|
290 |
L
|
S
|
V
|
L
|
W
|
Q
|
M
|
R
|
Y
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
No endogenous ligands available
STRUCTURE MODELS
STRUCTURES
No structures available