G12 - 5-HT1A receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 138 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 138 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM5 A 222 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 A 222 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM6 T 346 6x36 G.H5 L 380 G.H5.25
Ionic ICL2 R 148 34x57 G.H5 D 377 G.H5.22
Polar ICL2 N 146 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 N 146 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 N 146 34x55 G.hns1 R 56 G.hns1.03
Polar TM6 K 342 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 342 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 342 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM3 I 138 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 138 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM5 R 225 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 225 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL2 I 142 34x51 G.H5 I 370 G.H5.15
Polar TM5 R 225 5x68 G.H5 K 367 G.H5.12
Van-der-waals TM5 R 225 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM7 Y 400 7x53 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 141 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 141 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 V 145 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL3 F 321 - G.H4 Q 333 G.H4.13
Van-der-waals ICL3 F 321 - G.H4 Q 333 G.H4.13
Hydrophobic ICL2 I 142 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 I 142 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM5 I 218 5x61 G.H5 I 378 G.H5.23
Hydrophobic TM7 F 403 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 403 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM6 K 342 6x32 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 141 34x50 G.H5 L 371 G.H5.16
Polar TM6 N 325 6x15 G.H4 Q 333 G.H4.13
Ionic TM5 R 225 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 225 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 225 5x68 G.H5 D 368 G.H5.13
Polar ICL3 C 316 - G.H4 R 323 G.H4.03
Hydrophobic ICL3 C 316 - G.H4 R 323 G.H4.03
Van-der-waals ICL3 C 316 - G.H4 R 323 G.H4.03
Hydrophobic TM6 T 343 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 343 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM3 I 138 3x54 G.H5 L 375 G.H5.20
Polar TM5 K 228 5x71 G.H5 H 364 G.H5.09
Van-der-waals TM5 K 228 5x71 G.H5 H 364 G.H5.09
Hydrophobic ICL3 A 317 - G.H4 R 329 G.H4.09
Hydrophobic TM3 I 138 3x54 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 141 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 141 34x50 G.H5 I 370 G.H5.15
Polar ICL3 T 236 - G.H4 R 329 G.H4.09
Polar TM6 R 339 6x29 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 R 339 6x29 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 I 350 6x40 G.H5 L 380 G.H5.25
Hydrophobic H8 K 405 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 405 8x48 G.H5 Q 381 G.H5.26
Polar TM6 T 346 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 346 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM3 R 134 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM4 R 151 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 R 151 4x40 G.HN R 52 G.HN.52
Hydrophobic ICL2 I 142 34x51 G.H5 K 367 G.H5.12
Hydrophobic H8 N 404 8x47 G.H5 L 380 G.H5.25
Polar TM3 A 137 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 137 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 137 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 I 142 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 I 142 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM7 I 399 7x52 G.H5 L 380 G.H5.25
Van-der-waals TM7 I 399 7x52 G.H5 L 380 G.H5.25
Hydrophobic TM6 L 347 6x37 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 I 378 G.H5.23
Polar TM3 R 134 3x50 G.H5 D 377 G.H5.22