Gs - 5-HT6 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 211 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 211 5x61 G.H5 L 393 G.H5.25
Ionic ICL2 R 133 34x52 G.s2s3 D 215 G.s2s3.01
Polar ICL2 R 133 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 R 133 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 133 34x52 G.s2s3 D 215 G.s2s3.01
Polar H8 D 326 8x49 G.H5 Q 390 G.H5.22
Hydrophobic H8 D 326 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 D 326 8x49 G.H5 Q 390 G.H5.22
Polar H8 R 325 8x48 G.H5 L 394 G.H5.26
Van-der-waals H8 R 325 8x48 G.H5 L 394 G.H5.26
Polar H8 R 325 8x48 G.H5 R 389 G.H5.21
Hydrophobic H8 R 325 8x48 G.H5 R 389 G.H5.21
Van-der-waals H8 R 325 8x48 G.H5 R 389 G.H5.21
Hydrophobic ICL2 P 131 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM3 R 124 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 124 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 132 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM5 V 222 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 V 222 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 132 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 132 34x51 G.H5 F 376 G.H5.08
Polar ICL2 L 132 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 132 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 132 34x51 G.S1 H 41 G.S1.02
Polar TM5 Q 218 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 218 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 A 215 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 131 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 132 34x51 G.S3 F 219 G.S3.03
Hydrophobic TM3 I 128 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 Q 218 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM3 I 128 3x54 G.H5 L 393 G.H5.25
Hydrophobic C-term L 364 - G.s4h3 D 260 G.s4h3.11
Van-der-waals C-term L 364 - G.s4h3 D 260 G.s4h3.11
Hydrophobic TM5 A 214 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 218 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 132 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM3 I 128 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL3 M 229 - G.H4 R 347 G.H4.17
Van-der-waals ICL3 M 229 - G.H4 R 347 G.H4.17
Hydrophobic TM5 L 225 5x75 G.S6 P 361 G.S6.03
Hydrophobic TM6 A 266 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 266 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 K 135 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic TM5 A 214 5x64 G.H5 L 388 G.H5.20
Polar TM5 Q 218 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 218 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 218 5x68 G.H5 Q 384 G.H5.16
Polar TM3 L 127 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 127 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 127 3x53 G.H5 H 387 G.H5.19
Van-der-waals H8 M 324 8x47 G.H5 Q 390 G.H5.22
Polar TM5 Q 221 5x71 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 132 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 132 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM6 T 269 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 269 6x36 G.H5 L 393 G.H5.25
Polar TM5 Q 221 5x71 G.H5 D 381 G.H5.13
Van-der-waals TM5 Q 221 5x71 G.H5 D 381 G.H5.13
Ionic H8 K 328 8x51 G.H5 E 392 G.H5.24
Polar H8 K 328 8x51 G.H5 E 392 G.H5.24
Hydrophobic H8 K 328 8x51 G.H5 E 392 G.H5.24
Van-der-waals H8 K 328 8x51 G.H5 E 392 G.H5.24
Polar TM6 K 265 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 265 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 265 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 131 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 131 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 V 222 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 P 131 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 131 34x50 G.H5 R 380 G.H5.12
Ionic H8 R 325 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 R 325 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM7 F 323 7x56 G.H5 Y 391 G.H5.23
Van-der-waals TM7 F 323 7x56 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 133 34x52 G.S3 V 217 G.S3.01
Van-der-waals ICL2 R 133 34x52 G.S3 V 217 G.S3.01
Hydrophobic TM3 L 127 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 127 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 M 229 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 M 229 - G.H4 L 346 G.H4.16
Hydrophobic TM3 I 128 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 A 219 5x69 G.H5 L 394 G.H5.26
Polar TM3 I 128 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 128 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 128 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 270 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 270 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 132 34x51 G.H5 C 379 G.H5.11
Polar TM5 Q 218 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 Q 218 5x68 G.H5 D 381 G.H5.13
Polar TM6 K 265 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 265 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 265 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM5 A 215 5x65 G.H5 L 393 G.H5.25
Polar H8 R 325 8x48 G.H5 Q 390 G.H5.22
Hydrophobic H8 R 325 8x48 G.H5 Q 390 G.H5.22
Van-der-waals H8 R 325 8x48 G.H5 Q 390 G.H5.22
Polar C-term S 350 - G.H3 R 280 G.H3.16
Hydrophobic C-term S 350 - G.H3 R 280 G.H3.16
Van-der-waals C-term S 350 - G.H3 R 280 G.H3.16
Hydrophobic ICL3 M 229 - G.h4s6 T 350 G.h4s6.03
Polar TM6 T 269 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM7 F 323 7x56 G.H5 E 392 G.H5.24
Hydrophobic H8 M 324 8x47 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 G 228 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 G 228 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 M 229 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 M 229 - G.H4 D 343 G.H4.13
Hydrophobic ICL2 K 135 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 K 135 34x54 G.hns1 R 38 G.hns1.02