G12 - M5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 S 235 - G.H4 R 329 G.H4.09
Hydrophobic ICL2 L 136 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 R 139 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM4 R 146 4x41 G.HN R 52 G.HN.52
Van-der-waals TM4 R 146 4x41 G.HN R 52 G.HN.52
Ionic TM5 R 223 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 223 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 223 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 223 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM6 L 444 6x37 G.H5 L 380 G.H5.25
Van-der-waals TM6 L 444 6x37 G.H5 L 380 G.H5.25
Hydrophobic TM5 L 227 5x72 G.h4s6 P 345 G.h4s6.20
Ionic ICL2 R 142 34x57 G.H5 D 377 G.H5.22
Polar ICL2 R 142 34x57 G.H5 D 377 G.H5.22
Hydrophobic TM3 I 132 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM5 I 216 5x61 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 132 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 132 3x54 G.H5 L 371 G.H5.16
Van-der-waals ICL3 R 429 - G.h4s6 R 339 G.h4s6.08
Hydrophobic TM6 T 443 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM7 C 498 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 C 498 7x56 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 135 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 A 140 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 A 140 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 K 439 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 439 6x32 G.H5 Q 381 G.H5.26
Ionic ICL2 R 139 34x54 G.H5 E 373 G.H5.18
Polar ICL2 R 139 34x54 G.H5 E 373 G.H5.18
Hydrophobic ICL2 L 136 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 136 34x51 G.H5 I 370 G.H5.15
Polar TM5 R 223 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM5 R 223 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 R 223 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM5 L 227 5x72 G.S6 F 347 G.S6.02
Van-der-waals TM5 L 227 5x72 G.S6 F 347 G.S6.02
Hydrophobic TM5 R 223 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 223 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM5 L 230 5x75 G.S6 F 347 G.S6.02
Van-der-waals TM5 L 230 5x75 G.S6 F 347 G.S6.02
Hydrophobic ICL3 Q 231 - G.S6 F 347 G.S6.02
Hydrophobic ICL2 L 136 34x51 G.H5 V 366 G.H5.11
Polar TM6 K 436 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 436 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 436 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM3 I 132 3x54 G.H5 L 380 G.H5.25
Van-der-waals TM3 I 132 3x54 G.H5 L 380 G.H5.25
Polar TM3 S 131 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 131 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 131 3x53 G.H5 N 374 G.H5.19
Polar TM6 A 440 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 440 6x33 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 135 34x50 G.H5 K 367 G.H5.12
Polar TM6 K 436 6x29 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 L 136 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 136 34x51 G.S1 V 58 G.S1.02
Hydrophobic ICL3 V 236 - G.H4 R 329 G.H4.09
Hydrophobic TM7 A 496 7x54 G.H5 M 379 G.H5.24
Van-der-waals TM7 A 496 7x54 G.H5 M 379 G.H5.24
Hydrophobic TM5 L 230 5x75 G.H5 D 368 G.H5.13
Polar ICL2 A 140 34x55 G.HN R 52 G.HN.52
Hydrophobic ICL2 L 136 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 136 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 P 135 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM5 L 230 5x75 G.H5 H 364 G.H5.09
Polar TM5 R 223 5x68 G.H5 Q 381 G.H5.26
Van-der-waals TM5 R 223 5x68 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 A 140 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 Q 231 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 Q 231 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM7 Y 495 7x53 G.H5 M 379 G.H5.24
Van-der-waals TM7 Y 495 7x53 G.H5 M 379 G.H5.24
Hydrophobic TM5 L 230 5x75 G.H5 F 361 G.H5.06
Van-der-waals TM5 L 230 5x75 G.H5 F 361 G.H5.06
Van-der-waals TM2 N 65 2x39 G.H5 I 378 G.H5.23
Hydrophobic H8 N 499 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 N 499 8x47 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 136 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 136 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 T 137 34x52 G.S3 I 221 G.S3.01
Polar ICL3 Q 231 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 Q 231 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 Q 231 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 G 232 - G.S6 H 348 G.S6.03
Hydrophobic TM3 S 131 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 S 131 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM5 R 223 5x68 G.H5 L 375 G.H5.20
Van-der-waals TM5 R 223 5x68 G.H5 L 375 G.H5.20
Polar ICL2 R 142 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 I 132 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM5 L 230 5x75 G.H5 A 365 G.H5.10
Ionic TM5 E 219 5x64 G.H5 K 367 G.H5.12
Polar TM5 E 219 5x64 G.H5 K 367 G.H5.12
Van-der-waals TM5 E 219 5x64 G.H5 K 367 G.H5.12
Hydrophobic TM5 L 227 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 L 227 5x72 G.H5 D 368 G.H5.13
Polar TM5 L 230 5x75 G.S6 H 348 G.S6.03
Van-der-waals TM5 L 230 5x75 G.S6 H 348 G.S6.03
Polar H8 N 499 8x47 G.H5 D 377 G.H5.22
Ionic ICL3 R 429 - G.H4 D 336 G.H4.16
Polar ICL3 R 429 - G.H4 D 336 G.H4.16
Van-der-waals ICL3 R 429 - G.H4 D 336 G.H4.16
Ionic TM5 D 226 5x71 G.H5 H 364 G.H5.09
Hydrophobic ICL3 Q 231 - G.S6 L 346 G.S6.01
Polar TM3 R 128 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 128 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 128 3x50 G.H5 I 378 G.H5.23