G13 - α2B-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 88.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 F 369 6x33 G.H5 L 376 G.H5.25
Van-der-waals TM6 F 369 6x33 G.H5 L 376 G.H5.25
Polar ICL2 R 124 34x57 G.H5 Q 373 G.H5.22
Polar TM2 Q 47 2x39 G.H5 Q 373 G.H5.22
Hydrophobic TM3 V 114 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 V 114 3x54 G.H5 L 367 G.H5.16
Hydrophobic TM5 A 199 5x65 G.H5 L 376 G.H5.25
Hydrophobic TM7 I 425 7x52 G.H5 M 375 G.H5.24
Van-der-waals TM7 I 425 7x52 G.H5 M 375 G.H5.24
Hydrophobic TM1 L 35 1x55 G.HN M 1 G.HN.01
Van-der-waals TM1 L 35 1x55 G.HN M 1 G.HN.01
Polar ICL2 S 122 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 S 122 34x55 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 S 122 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 L 118 34x51 G.H5 I 366 G.H5.15
Van-der-waals ICL2 L 118 34x51 G.H5 I 366 G.H5.15
Hydrophobic TM6 R 368 6x32 G.H5 Q 377 G.H5.26
Van-der-waals TM6 R 368 6x32 G.H5 Q 377 G.H5.26
Hydrophobic TM7 F 429 7x56 G.H5 M 375 G.H5.24
Van-der-waals TM7 F 429 7x56 G.H5 M 375 G.H5.24
Hydrophobic H8 N 430 8x47 G.H5 M 375 G.H5.24
Van-der-waals H8 N 430 8x47 G.H5 M 375 G.H5.24
Hydrophobic ICL2 A 117 34x50 G.H5 L 367 G.H5.16
Hydrophobic TM5 I 198 5x64 G.H5 L 367 G.H5.16
Polar ICL3 R 358 - G.h4s6 Q 337 G.h4s6.11
Hydrophobic TM7 Y 426 7x53 G.H5 M 375 G.H5.24
Van-der-waals TM7 Y 426 7x53 G.H5 M 375 G.H5.24
Hydrophobic ICL2 L 118 34x51 G.S1 V 49 G.S1.02
Hydrophobic TM5 A 199 5x65 G.H5 L 371 G.H5.20
Hydrophobic ICL2 L 118 34x51 G.H5 F 359 G.H5.08
Van-der-waals ICL2 L 118 34x51 G.H5 F 359 G.H5.08
Polar TM3 A 113 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 A 113 3x53 G.H5 N 370 G.H5.19
Van-der-waals TM3 A 113 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM5 S 202 5x68 G.H5 L 367 G.H5.16
Hydrophobic TM1 T 39 1x59 G.HN M 1 G.HN.01
Van-der-waals TM1 T 39 1x59 G.HN M 1 G.HN.01
Hydrophobic TM3 R 110 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 110 3x50 G.H5 L 374 G.H5.23
Hydrophobic ICL2 A 117 34x50 G.H5 I 366 G.H5.15
Hydrophobic TM5 S 202 5x68 G.H5 L 371 G.H5.20
Hydrophobic TM5 P 207 5x73 G.h4s6 P 341 G.h4s6.20
Hydrophobic TM3 R 110 3x50 G.H5 M 375 G.H5.24
Van-der-waals TM3 R 110 3x50 G.H5 M 375 G.H5.24
Hydrophobic TM3 V 114 3x54 G.H5 L 374 G.H5.23
Van-der-waals TM3 V 114 3x54 G.H5 L 374 G.H5.23
Hydrophobic ICL2 L 118 34x51 G.H5 K 363 G.H5.12
Hydrophobic TM1 L 38 1x58 G.HN F 4 G.HN.04
Van-der-waals TM1 L 38 1x58 G.HN F 4 G.HN.04
Hydrophobic TM3 V 114 3x54 G.H5 L 371 G.H5.20
Van-der-waals TM3 V 114 3x54 G.H5 L 371 G.H5.20
Polar ICL3 G 212 - G.H4 K 324 G.H4.09
Hydrophobic ICL3 R 358 - G.H4 R 331 G.H4.16
Van-der-waals ICL3 R 358 - G.H4 R 331 G.H4.16
Hydrophobic ICL1 R 44 12x51 G.HN F 4 G.HN.04
Van-der-waals ICL1 R 44 12x51 G.HN F 4 G.HN.04
Hydrophobic TM6 R 365 6x29 G.H5 Q 377 G.H5.26
Van-der-waals TM6 R 365 6x29 G.H5 Q 377 G.H5.26
Hydrophobic ICL2 L 118 34x51 G.S3 V 216 G.S3.01
Hydrophobic ICL3 G 211 - G.H4 K 324 G.H4.09
Hydrophobic TM7 T 427 7x54 G.H5 M 375 G.H5.24