Go - AT1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 M 134 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM5 L 222 5x65 G.H5 I 344 G.H5.16
Ionic TM6 R 234 6x29 G.H5 D 341 G.H5.13
Polar TM6 R 234 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 234 6x29 G.H5 D 341 G.H5.13
Polar C-term N 344 - G.s4h3 E 237 G.s4h3.10
Hydrophobic C-term N 344 - G.s4h3 E 237 G.s4h3.10
Polar ICL3 K 232 - G.S6 I 319 G.S6.01
Van-der-waals C-term V 345 - G.H2 R 206 G.H2.01
Hydrophobic ICL2 L 138 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 L 138 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic C-term S 342 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term S 342 - G.s4h3 E 237 G.s4h3.10
Hydrophobic ICL2 P 133 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 133 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 M 134 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 M 134 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM6 I 245 6x40 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 245 6x40 G.H5 L 353 G.H5.25
Van-der-waals ICL2 P 133 34x50 G.H5 N 347 G.H5.19
Polar C-term K 351 - H.hbhc M 114 H.hbhc.02
Hydrophobic C-term K 351 - H.hbhc M 114 H.hbhc.02
Van-der-waals C-term K 351 - H.hbhc M 114 H.hbhc.02
Hydrophobic TM3 R 126 3x50 G.H5 L 353 G.H5.25
Ionic C-term D 343 - G.H2 R 206 G.H2.01
Polar C-term D 343 - G.H2 R 206 G.H2.01
Hydrophobic C-term D 343 - G.H2 R 206 G.H2.01
Van-der-waals C-term D 343 - G.H2 R 206 G.H2.01
Hydrophobic ICL2 M 134 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 M 134 34x51 G.S3 L 195 G.S3.01
Hydrophobic C-term F 356 - H.HA Q 68 H.HA.06
Van-der-waals C-term F 356 - H.HA Q 68 H.HA.06
Polar C-term R 340 - G.H2 E 208 G.H2.03
Hydrophobic C-term R 340 - G.H2 E 208 G.H2.03
Van-der-waals C-term R 340 - G.H2 E 208 G.H2.03
Hydrophobic TM5 L 222 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 I 241 6x36 G.H5 L 353 G.H5.25
Polar C-term R 340 - G.H2 R 206 G.H2.01
Polar ICL2 R 137 34x54 G.S1 D 33 G.S1.01
Hydrophobic TM3 I 130 3x54 G.H5 L 353 G.H5.25
Polar ICL3 Q 229 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 Q 229 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 Q 229 - G.H5 D 341 G.H5.13
Hydrophobic H8 G 306 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 A 129 3x53 G.H5 C 351 G.H5.23
Polar TM3 R 126 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 126 3x50 G.H5 C 351 G.H5.23
Polar ICL2 R 137 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 137 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 137 34x54 G.hns1 A 31 G.hns1.02
Ionic TM6 R 234 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 234 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 234 6x29 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 234 6x29 G.h4s6 E 318 G.h4s6.12
Polar C-term Y 339 - G.H2 E 208 G.H2.03
Hydrophobic C-term Y 339 - G.H2 E 208 G.H2.03
Van-der-waals C-term Y 339 - G.H2 E 208 G.H2.03
Hydrophobic TM3 I 130 3x54 G.H5 I 344 G.H5.16
Polar TM6 R 234 6x29 G.S6 Y 320 G.S6.02
Hydrophobic TM7 L 305 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 L 305 7x56 G.H5 G 352 G.H5.24
Polar C-term K 351 - H.hbhc R 113 H.hbhc.01
Van-der-waals C-term K 351 - H.hbhc R 113 H.hbhc.01
Hydrophobic C-term T 349 - H.hbhc M 114 H.hbhc.02
Van-der-waals C-term T 349 - H.hbhc M 114 H.hbhc.02
Hydrophobic H8 K 307 8x48 G.H5 Y 354 G.H5.26
Van-der-waals H8 K 307 8x48 G.H5 Y 354 G.H5.26
Hydrophobic TM6 I 238 6x33 G.H5 Y 354 G.H5.26
Van-der-waals TM6 I 238 6x33 G.H5 Y 354 G.H5.26
Polar TM3 A 129 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 129 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 129 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 130 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 130 3x54 G.H5 L 348 G.H5.20
Hydrophobic C-term S 338 - G.H2 E 208 G.H2.03
Van-der-waals C-term S 338 - G.H2 E 208 G.H2.03
Hydrophobic ICL2 L 138 34x55 G.HN I 28 G.HN.52
Ionic ICL3 K 232 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 K 232 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 K 232 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 K 232 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 P 133 34x50 G.H5 I 344 G.H5.16