Gi1 - BB3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 13.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 P 82 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 P 82 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM3 A 148 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 148 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 I 269 6x33 G.H5 L 348 G.H5.20
Polar TM3 A 148 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 148 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 148 3x53 G.H5 N 347 G.H5.19
Polar C-term T 360 - G.H3 K 257 G.H3.16
Hydrophobic TM3 V 149 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 149 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 244 5x65 G.H5 I 344 G.H5.16
Polar H8 S 334 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 334 8x47 G.H5 G 352 G.H5.24
Polar TM6 Q 262 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 Q 262 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 Q 262 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM2 P 82 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 P 82 2x39 G.H5 C 351 G.H5.23
Polar ICL2 R 155 34x53 G.h2s4 T 219 G.h2s4.05
Hydrophobic TM6 I 269 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 I 269 6x33 G.H5 F 354 G.H5.26
Ionic TM6 R 266 6x30 G.H5 D 341 G.H5.13
Polar TM6 R 266 6x30 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 266 6x30 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 266 6x30 G.H5 D 341 G.H5.13
Hydrophobic TM6 S 265 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 S 265 6x29 G.H5 F 354 G.H5.26
Ionic ICL2 E 154 34x52 G.hns1 R 32 G.hns1.03
Polar ICL3 E 254 - G.S6 F 323 G.S6.05
Hydrophobic ICL3 E 254 - G.S6 F 323 G.S6.05
Van-der-waals ICL3 E 254 - G.S6 F 323 G.S6.05
Polar H8 S 334 8x47 G.H5 F 354 G.H5.26
Hydrophobic H8 S 334 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 S 334 8x47 G.H5 F 354 G.H5.26
Polar TM6 Q 262 6x26 G.S6 Y 320 G.S6.02
Hydrophobic C-term L 362 - G.H2 I 212 G.H2.08
Van-der-waals C-term L 362 - G.H2 I 212 G.H2.08
Polar H8 K 335 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL2 L 153 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 153 34x51 G.S3 L 194 G.S3.01
Polar ICL2 P 152 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 152 34x50 G.H5 N 347 G.H5.19
Hydrophobic C-term L 365 - G.H2 R 208 G.H2.04
Hydrophobic TM6 I 269 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 269 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 152 34x50 G.H5 I 344 G.H5.16
Polar ICL2 R 155 34x53 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 155 34x53 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 155 34x53 G.hns1 A 31 G.hns1.02
Polar TM2 T 80 2x37 G.H5 D 350 G.H5.22
Polar TM6 Q 262 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 Q 262 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 Q 262 6x26 G.H5 D 341 G.H5.13
Van-der-waals C-term L 365 - G.H3 S 252 G.H3.11
Hydrophobic ICL2 P 152 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 152 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM7 L 333 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 L 333 7x56 G.H5 G 352 G.H5.24
Polar TM6 H 258 6x22 G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 L 153 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM3 R 145 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 145 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 P 252 5x73 G.H5 F 334 G.H5.06
Van-der-waals TM5 P 252 5x73 G.H5 F 334 G.H5.06
Hydrophobic TM6 R 266 6x30 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 273 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 273 6x37 G.H5 L 353 G.H5.25
Polar C-term A 358 - G.H3 K 257 G.H3.16
Van-der-waals C-term A 358 - G.H3 K 257 G.H3.16
Hydrophobic ICL2 P 152 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL2 L 153 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 153 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM5 P 252 5x73 G.H5 A 338 G.H5.10
Van-der-waals TM5 P 252 5x73 G.H5 A 338 G.H5.10
Hydrophobic TM5 L 244 5x65 G.H5 L 348 G.H5.20
Ionic ICL3 E 254 - G.S6 H 322 G.S6.04
Polar ICL3 E 254 - G.S6 H 322 G.S6.04
Hydrophobic ICL3 E 254 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 E 254 - G.S6 H 322 G.S6.04
Hydrophobic TM5 P 252 5x73 G.H5 D 337 G.H5.09
Van-der-waals TM5 P 252 5x73 G.H5 D 337 G.H5.09
Hydrophobic TM5 P 252 5x73 G.S6 Y 320 G.S6.02
Polar TM7 L 333 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM7 L 333 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 L 333 7x56 G.H5 F 354 G.H5.26
Hydrophobic ICL3 E 255 - G.H4 Q 304 G.H4.12
Van-der-waals ICL3 E 255 - G.H4 Q 304 G.H4.12
Polar C-term V 357 - G.H3 K 257 G.H3.16
Hydrophobic C-term V 357 - G.H3 K 257 G.H3.16
Van-der-waals C-term V 357 - G.H3 K 257 G.H3.16
Hydrophobic C-term L 362 - G.h2s4 F 215 G.h2s4.01
Polar TM3 R 145 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 145 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 145 3x50 G.H5 C 351 G.H5.23
Polar ICL2 R 155 34x53 G.hns1 A 30 G.hns1.01
Hydrophobic ICL2 R 155 34x53 G.hns1 A 30 G.hns1.01
Van-der-waals ICL2 R 155 34x53 G.hns1 A 30 G.hns1.01
Ionic TM6 H 258 6x22 G.h4s6 E 318 G.h4s6.12
Polar TM6 H 258 6x22 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 H 258 6x22 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 H 258 6x22 G.h4s6 E 318 G.h4s6.12
Polar ICL2 R 155 34x53 G.S1 E 33 G.S1.01
Van-der-waals ICL2 R 155 34x53 G.S1 E 33 G.S1.01
Hydrophobic TM7 L 333 7x56 G.H5 L 353 G.H5.25
Hydrophobic ICL3 E 255 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 E 255 - G.H4 E 308 G.H4.16