G13 - C5a2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 76.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ECL2 H 176 - G.S1 L 48 G.S1.01
Hydrophobic ECL2 E 178 - G.H5 L 374 G.H5.23
Van-der-waals ECL2 E 178 - G.H5 L 374 G.H5.23
Aromatic N-term Y 8 - G.S6 F 346 G.S6.05
Hydrophobic N-term Y 8 - G.S6 F 346 G.S6.05
Van-der-waals N-term Y 8 - G.S6 F 346 G.S6.05
Hydrophobic ECL2 F 180 - G.H5 L 367 G.H5.16
Van-der-waals ECL2 F 180 - G.H5 L 367 G.H5.16
Polar ECL2 G 192 - G.HN L 38 G.HN.47
Van-der-waals ECL2 G 192 - G.HN L 38 G.HN.47
Van-der-waals TM7 A 267 7x28 G.H5 M 375 G.H5.24
Hydrophobic ECL2 V 187 45x51 G.HN T 43 G.HN.52
Van-der-waals ECL2 V 187 45x51 G.HN T 43 G.HN.52
Polar ECL2 H 176 - G.hns1 R 47 G.hns1.03
Hydrophobic ECL2 H 176 - G.hns1 R 47 G.hns1.03
Van-der-waals ECL2 H 176 - G.hns1 R 47 G.hns1.03
Hydrophobic N-term P 20 - G.H5 D 364 G.H5.13
Van-der-waals N-term P 20 - G.H5 D 364 G.H5.13
Hydrophobic N-term V 21 - G.H5 L 371 G.H5.20
Van-der-waals N-term V 21 - G.H5 L 371 G.H5.20
Hydrophobic ECL2 R 174 - G.HN T 43 G.HN.52
Hydrophobic ECL2 R 174 - G.hns1 V 45 G.hns1.01
Polar ECL2 Q 177 - G.hns1 K 46 G.hns1.02
Hydrophobic ECL2 Q 177 - G.hns1 K 46 G.hns1.02
Van-der-waals ECL2 Q 177 - G.hns1 K 46 G.hns1.02
Polar TM5 S 193 5x32 G.HN R 40 G.HN.49
Hydrophobic TM5 S 193 5x32 G.HN R 40 G.HN.49
Van-der-waals TM5 S 193 5x32 G.HN R 40 G.HN.49
Polar ECL2 G 191 - G.HN R 40 G.HN.49
Hydrophobic ECL2 G 191 - G.HN R 40 G.HN.49
Van-der-waals ECL2 G 191 - G.HN R 40 G.HN.49
Polar N-term D 15 - G.H5 K 372 G.H5.21
Hydrophobic ECL2 Q 185 - G.HN Y 44 G.HN.53
Van-der-waals ECL2 Q 185 - G.HN Y 44 G.HN.53
Hydrophobic N-term V 21 - G.H5 L 367 G.H5.16
Van-der-waals N-term V 21 - G.H5 L 367 G.H5.16
Van-der-waals ECL2 R 183 - G.H5 L 371 G.H5.20
Hydrophobic ECL2 A 182 - G.s2s3 N 215 G.s2s3.02
Van-der-waals ECL2 A 182 - G.s2s3 N 215 G.s2s3.02
Ionic TM5 E 197 5x36 G.HN K 42 G.HN.51
Polar TM5 E 197 5x36 G.HN K 42 G.HN.51
Hydrophobic TM5 E 197 5x36 G.HN K 42 G.HN.51
Van-der-waals TM5 E 197 5x36 G.HN K 42 G.HN.51
Hydrophobic ECL2 G 191 - G.HN E 41 G.HN.50
Hydrophobic N-term D 22 - G.H5 L 367 G.H5.16
Polar ECL3 N 262 - G.h3s5 N 283 G.h3s5.02
Hydrophobic ECL3 N 262 - G.h3s5 N 283 G.h3s5.02
Van-der-waals ECL3 N 262 - G.h3s5 N 283 G.h3s5.02
Van-der-waals ECL2 G 192 - G.HN D 35 G.HN.44
Hydrophobic ECL3 N 262 - G.H5 L 376 G.H5.25
Van-der-waals ECL3 N 262 - G.H5 L 376 G.H5.25
Hydrophobic N-term V 21 - G.H5 H 368 G.H5.17
Van-der-waals N-term V 21 - G.H5 H 368 G.H5.17
Polar ECL2 G 192 - G.HN S 39 G.HN.48
Hydrophobic ECL2 G 192 - G.HN S 39 G.HN.48
Van-der-waals ECL2 G 192 - G.HN S 39 G.HN.48
Hydrophobic ECL2 F 180 - G.S2 I 213 G.S2.08
Van-der-waals ECL2 F 180 - G.S2 I 213 G.S2.08
Ionic N-term D 12 - G.H4 R 331 G.H4.16
Polar N-term D 12 - G.H4 R 331 G.H4.16
Van-der-waals N-term D 12 - G.H4 R 331 G.H4.16
Polar ECL2 H 179 - G.s2s3 N 215 G.s2s3.02
Hydrophobic ECL2 H 179 - G.s2s3 N 215 G.s2s3.02
Van-der-waals ECL2 H 179 - G.s2s3 N 215 G.s2s3.02
Hydrophobic ECL2 V 187 45x51 G.HN Y 44 G.HN.53
Van-der-waals ECL2 V 187 45x51 G.HN Y 44 G.HN.53
Polar ECL3 N 262 - G.H5 Q 373 G.H5.22
Hydrophobic ECL3 N 262 - G.H5 Q 373 G.H5.22
Van-der-waals ECL3 N 262 - G.H5 Q 373 G.H5.22
Hydrophobic N-term L 16 - G.H5 T 365 G.H5.14
Van-der-waals N-term L 16 - G.H5 T 365 G.H5.14
Hydrophobic TM7 S 263 7x24 G.H5 L 376 G.H5.25
Van-der-waals TM7 S 263 7x24 G.H5 L 376 G.H5.25
Aromatic N-term Y 10 - G.S6 H 345 G.S6.04
Hydrophobic N-term Y 10 - G.S6 H 345 G.S6.04
Van-der-waals N-term Y 10 - G.S6 H 345 G.S6.04
Polar ECL2 Y 190 - G.HN R 40 G.HN.49
Hydrophobic ECL2 Y 190 - G.HN R 40 G.HN.49
Van-der-waals ECL2 Y 190 - G.HN R 40 G.HN.49
Hydrophobic ECL2 G 192 - G.HN K 36 G.HN.45
Van-der-waals ECL2 G 192 - G.HN K 36 G.HN.45
Polar ECL2 D 189 - G.HN T 43 G.HN.52
Hydrophobic ECL2 D 189 - G.HN T 43 G.HN.52
Van-der-waals ECL2 D 189 - G.HN T 43 G.HN.52
Hydrophobic N-term L 16 - G.H5 H 368 G.H5.17
Ionic ECL2 H 179 - G.S2 E 212 G.S2.07
Hydrophobic ECL2 H 179 - G.S2 E 212 G.S2.07
Polar N-term Y 13 - G.S6 H 345 G.S6.04
Aromatic N-term Y 13 - G.S6 H 345 G.S6.04
Hydrophobic N-term Y 13 - G.S6 H 345 G.S6.04
Van-der-waals N-term Y 13 - G.S6 H 345 G.S6.04
Aromatic ECL2 F 180 - G.S3 F 218 G.S3.03
Hydrophobic ECL2 F 180 - G.S3 F 218 G.S3.03
Van-der-waals ECL2 F 180 - G.S3 F 218 G.S3.03
Hydrophobic TM7 R 271 7x32 G.H5 M 375 G.H5.24
Hydrophobic TM7 L 266 7x27 G.H5 L 376 G.H5.25
Van-der-waals TM7 L 266 7x27 G.H5 L 376 G.H5.25
Hydrophobic ECL2 C 186 45x50 G.HN Y 44 G.HN.53
Van-der-waals ECL2 C 186 45x50 G.HN Y 44 G.HN.53
Ionic N-term D 22 - G.H5 K 363 G.H5.12
Polar N-term D 22 - G.H5 K 363 G.H5.12
Hydrophobic N-term D 22 - G.H5 K 363 G.H5.12
Van-der-waals N-term D 22 - G.H5 K 363 G.H5.12
Polar ECL2 V 188 45x52 G.HN T 43 G.HN.52
Hydrophobic ECL2 V 188 45x52 G.HN T 43 G.HN.52
Van-der-waals ECL2 V 188 45x52 G.HN T 43 G.HN.52
Polar TM4 Y 172 4x64 G.HN R 40 G.HN.49
Polar N-term S 17 - G.H5 H 368 G.H5.17
Polar ECL2 H 179 - G.S3 V 216 G.S3.01
Hydrophobic ECL2 H 179 - G.S3 V 216 G.S3.01
Van-der-waals ECL2 H 179 - G.S3 V 216 G.S3.01
Polar ECL2 H 176 - G.hns1 K 46 G.hns1.02
Hydrophobic ECL2 H 176 - G.hns1 K 46 G.hns1.02
Van-der-waals ECL2 H 176 - G.hns1 K 46 G.hns1.02
Hydrophobic N-term D 12 - G.S6 L 342 G.S6.01
Polar ECL2 H 179 - G.hns1 K 46 G.hns1.02
Hydrophobic ECL2 H 179 - G.hns1 K 46 G.hns1.02
Van-der-waals ECL2 H 179 - G.hns1 K 46 G.hns1.02
Polar N-term Y 10 - G.S6 F 346 G.S6.05
Hydrophobic N-term Y 10 - G.S6 F 346 G.S6.05
Van-der-waals N-term Y 10 - G.S6 F 346 G.S6.05
Polar N-term Y 8 - G.H4 Q 323 G.H4.08
Hydrophobic N-term Y 8 - G.H4 Q 323 G.H4.08
Van-der-waals N-term Y 8 - G.H4 Q 323 G.H4.08
Polar TM5 S 193 5x32 G.HN S 39 G.HN.48
Hydrophobic TM5 S 193 5x32 G.HN S 39 G.HN.48
Van-der-waals TM5 S 193 5x32 G.HN S 39 G.HN.48
Polar TM5 S 194 5x33 G.HN S 39 G.HN.48
Hydrophobic TM5 S 194 5x33 G.HN S 39 G.HN.48
Van-der-waals TM5 S 194 5x33 G.HN S 39 G.HN.48
Polar N-term V 21 - G.H5 D 364 G.H5.13
Hydrophobic N-term V 21 - G.H5 D 364 G.H5.13
Van-der-waals N-term V 21 - G.H5 D 364 G.H5.13
Polar TM5 S 193 5x32 G.HN D 35 G.HN.44
Hydrophobic TM5 S 193 5x32 G.HN D 35 G.HN.44
Van-der-waals TM5 S 193 5x32 G.HN D 35 G.HN.44
Hydrophobic ECL3 P 261 - G.H5 Q 377 G.H5.26
Hydrophobic TM7 L 270 7x31 G.H5 Q 377 G.H5.26
Polar ECL2 H 176 - G.HN Y 44 G.HN.53
Hydrophobic ECL2 H 176 - G.HN Y 44 G.HN.53
Van-der-waals ECL2 H 176 - G.HN Y 44 G.HN.53
Polar ECL2 H 179 - G.S3 P 217 G.S3.02
Hydrophobic ECL2 H 179 - G.S3 P 217 G.S3.02
Van-der-waals ECL2 H 179 - G.S3 P 217 G.S3.02
Hydrophobic TM7 L 270 7x31 G.H5 L 376 G.H5.25
Van-der-waals TM7 L 270 7x31 G.H5 L 376 G.H5.25
Polar TM7 R 268 7x29 G.h4s6 Q 339 G.h4s6.13
Hydrophobic N-term Y 13 - G.H5 T 365 G.H5.14
Van-der-waals N-term Y 13 - G.H5 T 365 G.H5.14
Polar N-term D 22 - G.H5 D 364 G.H5.13
Van-der-waals N-term D 22 - G.H5 D 364 G.H5.13
Polar TM6 L 256 6x58 G.HN K 42 G.HN.51
Van-der-waals TM6 L 256 6x58 G.HN K 42 G.HN.51
Hydrophobic N-term L 16 - G.S6 Y 343 G.S6.02
Van-der-waals N-term L 16 - G.S6 Y 343 G.S6.02
Polar ECL2 V 188 45x52 G.HN K 42 G.HN.51
Hydrophobic ECL2 V 188 45x52 G.HN K 42 G.HN.51
Van-der-waals ECL2 V 188 45x52 G.HN K 42 G.HN.51
Polar ECL2 H 176 - G.hns1 V 45 G.hns1.01
Hydrophobic ECL2 H 176 - G.hns1 V 45 G.hns1.01
Van-der-waals ECL2 H 176 - G.hns1 V 45 G.hns1.01
Hydrophobic ECL2 F 180 - G.s2s3 K 214 G.s2s3.01
Van-der-waals ECL2 F 180 - G.s2s3 K 214 G.s2s3.01
Polar TM7 S 263 7x24 G.h3s5 N 283 G.h3s5.02
Hydrophobic TM7 S 263 7x24 G.h3s5 N 283 G.h3s5.02
Van-der-waals TM7 S 263 7x24 G.h3s5 N 283 G.h3s5.02
Polar N-term Y 13 - G.S6 H 344 G.S6.03
Hydrophobic N-term Y 13 - G.S6 H 344 G.S6.03
Van-der-waals N-term Y 13 - G.S6 H 344 G.S6.03
Hydrophobic TM7 A 267 7x28 G.H5 L 376 G.H5.25
Van-der-waals TM7 A 267 7x28 G.H5 L 376 G.H5.25
Polar ECL2 G 192 - G.HN R 40 G.HN.49
Hydrophobic ECL2 G 192 - G.HN R 40 G.HN.49
Van-der-waals ECL2 G 192 - G.HN R 40 G.HN.49
Hydrophobic N-term L 24 - G.s2s3 K 214 G.s2s3.01
Hydrophobic TM1 R 35 1x32 G.H5 M 375 G.H5.24
Hydrophobic ECL2 F 180 - G.S3 V 216 G.S3.01
Van-der-waals ECL2 F 180 - G.S3 V 216 G.S3.01
Hydrophobic N-term Y 10 - G.S6 H 344 G.S6.03
Van-der-waals N-term Y 10 - G.S6 H 344 G.S6.03
Aromatic N-term Y 13 - G.S6 Y 343 G.S6.02
Hydrophobic N-term Y 13 - G.S6 Y 343 G.S6.02
Van-der-waals N-term Y 13 - G.S6 Y 343 G.S6.02
Hydrophobic N-term Y 8 - G.HG T 293 G.HG.01
Van-der-waals N-term Y 8 - G.HG T 293 G.HG.01
Polar ECL2 G 192 - G.HN C 37 G.HN.46
Hydrophobic ECL2 G 192 - G.HN C 37 G.HN.46
Van-der-waals ECL2 G 192 - G.HN C 37 G.HN.46
Van-der-waals ECL2 H 179 - G.s2s3 K 214 G.s2s3.01
Hydrophobic TM7 L 266 7x27 G.H5 Q 377 G.H5.26
Hydrophobic TM7 L 270 7x31 G.H5 M 375 G.H5.24
Van-der-waals TM7 L 270 7x31 G.H5 M 375 G.H5.24
Hydrophobic N-term D 12 - G.S6 Y 343 G.S6.02
Van-der-waals N-term D 12 - G.S6 Y 343 G.S6.02
Hydrophobic ECL2 Y 190 - G.HN K 42 G.HN.51
Van-der-waals ECL2 Y 190 - G.HN K 42 G.HN.51
Polar TM5 S 193 5x32 G.HN K 36 G.HN.45
Hydrophobic TM5 S 193 5x32 G.HN K 36 G.HN.45
Van-der-waals TM5 S 193 5x32 G.HN K 36 G.HN.45
Hydrophobic TM7 A 264 7x25 G.h4s6 Q 339 G.h4s6.13
Van-der-waals TM7 A 264 7x25 G.h4s6 Q 339 G.h4s6.13
Ionic N-term D 12 - G.S6 H 344 G.S6.03
Polar N-term D 12 - G.S6 H 344 G.S6.03
Hydrophobic N-term D 12 - G.S6 H 344 G.S6.03
Van-der-waals N-term D 12 - G.S6 H 344 G.S6.03
Polar ECL3 P 261 - G.h3s5 N 283 G.h3s5.02
Hydrophobic ECL3 P 261 - G.h3s5 N 283 G.h3s5.02
Van-der-waals ECL3 P 261 - G.h3s5 N 283 G.h3s5.02
Hydrophobic TM7 L 270 7x31 G.H5 L 374 G.H5.23
Van-der-waals TM7 L 270 7x31 G.H5 L 374 G.H5.23
Ionic N-term D 22 - G.s2s3 K 214 G.s2s3.01
Polar N-term D 22 - G.s2s3 K 214 G.s2s3.01
Hydrophobic N-term D 22 - G.s2s3 K 214 G.s2s3.01
Van-der-waals N-term D 22 - G.s2s3 K 214 G.s2s3.01
Polar TM5 T 196 5x35 G.HN R 40 G.HN.49
Hydrophobic TM5 T 196 5x35 G.HN R 40 G.HN.49
Van-der-waals TM5 T 196 5x35 G.HN R 40 G.HN.49
Hydrophobic N-term D 12 - G.h4s6 P 341 G.h4s6.20
Polar ECL3 N 262 - G.H5 Q 377 G.H5.26
Van-der-waals ECL3 N 262 - G.H5 Q 377 G.H5.26