Gi2 - CB1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 S 217 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM3 S 217 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 S 217 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM6 L 345 6x37 G.H5 L 354 G.H5.25
Hydrophobic ICL3 D 324 - G.H4 S 306 G.H4.13
Hydrophobic ICL2 P 221 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 221 34x50 G.H5 I 344 G.H5.15
Hydrophobic ICL3 K 315 - G.H4 Q 305 G.H4.12
Van-der-waals ICL3 K 315 - G.H4 Q 305 G.H4.12
Hydrophobic TM6 R 340 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 R 340 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM5 M 308 5x72 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 M 308 5x72 G.h4s6 E 319 G.h4s6.12
Ionic ICL3 K 315 - G.H4 E 309 G.H4.16
Polar ICL3 K 315 - G.H4 E 309 G.H4.16
Hydrophobic ICL3 K 315 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 K 315 - G.H4 E 309 G.H4.16
Polar H8 K 402 8x48 G.H5 F 355 G.H5.26
Hydrophobic H8 K 402 8x48 G.H5 F 355 G.H5.26
Van-der-waals H8 K 402 8x48 G.H5 F 355 G.H5.26
Hydrophobic ICL2 L 222 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 222 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM6 M 337 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 M 337 6x29 G.H5 F 355 G.H5.26
Polar C-term S 425 - G.H3 K 258 G.H3.16
Polar TM6 L 341 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 L 341 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 341 6x33 G.H5 L 354 G.H5.25
Ionic TM5 R 311 5x75 G.H5 D 338 G.H5.09
Polar TM5 R 311 5x75 G.H5 D 338 G.H5.09
Hydrophobic TM5 R 311 5x75 G.H5 D 338 G.H5.09
Van-der-waals TM5 R 311 5x75 G.H5 D 338 G.H5.09
Hydrophobic TM3 I 218 3x54 G.H5 N 348 G.H5.19
Polar ICL2 K 225 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 K 225 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 225 34x54 G.hns1 A 31 G.hns1.02
Polar C-term S 452 - G.s4h3 D 238 G.s4h3.11
Hydrophobic C-term S 452 - G.s4h3 D 238 G.s4h3.11
Van-der-waals C-term S 452 - G.s4h3 D 238 G.s4h3.11
Hydrophobic ICL2 L 222 34x51 G.H5 T 341 G.H5.12
Ionic TM5 R 307 5x71 G.H5 D 342 G.H5.13
Polar TM5 R 307 5x71 G.H5 D 342 G.H5.13
Van-der-waals TM5 R 307 5x71 G.H5 D 342 G.H5.13
Hydrophobic TM6 D 333 6x25 G.h4s6 D 316 G.h4s6.09
Hydrophobic C-term M 461 - H.HB C 112 H.HB.14
Van-der-waals C-term M 461 - H.HB C 112 H.HB.14
Hydrophobic C-term V 463 - H.hbhc E 116 H.hbhc.04
Hydrophobic H8 K 402 8x48 G.H5 K 350 G.H5.21
Polar ICL3 K 315 - G.S6 I 320 G.S6.01
Hydrophobic TM5 A 301 5x65 G.H5 L 349 G.H5.20
Hydrophobic C-term M 461 - H.hbhc E 116 H.hbhc.04
Van-der-waals C-term M 461 - H.hbhc E 116 H.hbhc.04
Hydrophobic TM5 I 297 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM5 H 304 5x68 G.H5 I 345 G.H5.16
Hydrophobic ICL2 L 222 34x51 G.S3 L 195 G.S3.01
Polar TM6 Q 334 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 Q 334 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 Q 334 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 I 318 - G.H4 D 298 G.H4.04
Hydrophobic C-term V 454 - G.s4h3 D 238 G.s4h3.11
Polar TM3 S 217 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 S 217 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 S 217 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 I 218 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 218 3x54 G.H5 L 349 G.H5.20
Hydrophobic ICL3 I 318 - G.H4 S 302 G.H4.08
Van-der-waals ICL3 I 318 - G.H4 S 302 G.H4.08
Polar TM3 R 214 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 214 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 214 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM6 M 337 6x29 G.H5 K 346 G.H5.17
Hydrophobic H8 S 401 8x47 G.H5 G 353 G.H5.24
Ionic ICL3 R 331 - G.H4 E 309 G.H4.16
Hydrophobic ICL2 P 221 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 221 34x50 G.H5 I 345 G.H5.16
Ionic TM5 H 304 5x68 G.H5 D 342 G.H5.13
Polar TM5 H 304 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 H 304 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 H 304 5x68 G.H5 D 342 G.H5.13
Ionic TM5 R 311 5x75 G.H5 D 342 G.H5.13
Polar TM5 R 311 5x75 G.H5 D 342 G.H5.13
Van-der-waals TM5 R 311 5x75 G.H5 D 342 G.H5.13
Hydrophobic TM6 M 337 6x29 G.H5 L 349 G.H5.20
Van-der-waals TM6 M 337 6x29 G.H5 L 349 G.H5.20
Hydrophobic C-term I 450 - G.s4h3 E 240 G.s4h3.13
Van-der-waals C-term I 450 - G.s4h3 E 240 G.s4h3.13
Ionic TM2 R 150 2x37 G.H5 D 351 G.H5.22
Polar TM2 R 150 2x37 G.H5 D 351 G.H5.22
Hydrophobic TM2 R 150 2x37 G.H5 D 351 G.H5.22
Van-der-waals TM2 R 150 2x37 G.H5 D 351 G.H5.22
Hydrophobic ICL2 P 221 34x50 G.H5 T 341 G.H5.12
Hydrophobic ICL3 D 324 - G.H4 S 302 G.H4.08
Van-der-waals ICL3 D 324 - G.H4 S 302 G.H4.08
Hydrophobic C-term V 454 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term V 454 - G.s4h3 E 237 G.s4h3.10
Hydrophobic TM7 R 400 7x56 G.H5 G 353 G.H5.24
Hydrophobic C-term I 456 - G.H2 R 206 G.H2.01
Hydrophobic ICL2 L 222 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 L 222 34x51 G.H5 F 337 G.H5.08
Hydrophobic ICL2 R 226 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 M 308 5x72 G.H5 D 342 G.H5.13
Hydrophobic TM6 T 344 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 344 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM5 I 297 5x61 G.H5 L 349 G.H5.20
Hydrophobic TM6 L 341 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 L 341 6x33 G.H5 L 349 G.H5.20
Polar ICL2 P 221 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 221 34x50 G.H5 N 348 G.H5.19
Polar ICL3 K 315 - G.S6 T 322 G.S6.03
Hydrophobic ICL3 K 315 - G.S6 T 322 G.S6.03
Hydrophobic TM3 R 214 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM5 M 308 5x72 G.S6 Y 321 G.S6.02
Van-der-waals TM5 M 308 5x72 G.S6 Y 321 G.S6.02