G12 - CRF2 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 213 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 213 3x58 G.H5 L 371 G.H5.16
Ionic TM2 R 148 2x46 G.H5 D 377 G.H5.22
Polar TM2 R 148 2x46 G.H5 D 377 G.H5.22
Hydrophobic TM2 R 148 2x46 G.H5 D 377 G.H5.22
Van-der-waals TM2 R 148 2x46 G.H5 D 377 G.H5.22
Hydrophobic TM3 I 213 3x58 G.H5 L 375 G.H5.20
Hydrophobic TM3 I 213 3x58 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 213 3x58 G.H5 I 378 G.H5.23
Ionic TM5 K 293 5x64 G.H5 D 368 G.H5.13
Polar TM5 K 293 5x64 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 293 5x64 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 293 5x64 G.H5 D 368 G.H5.13
Hydrophobic ICL2 T 216 - G.H5 L 371 G.H5.16
Hydrophobic H8 N 363 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 Y 217 - G.S3 F 223 G.S3.03
Hydrophobic ICL2 T 216 - G.H5 I 370 G.H5.15
Hydrophobic TM6 A 311 6x41 G.H5 M 379 G.H5.24
Polar H8 G 364 8x48 G.H5 L 380 G.H5.25
Hydrophobic ICL2 Y 217 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 Y 217 - G.S3 I 221 G.S3.01
Hydrophobic ICL2 E 220 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 E 220 - G.hns1 R 55 G.hns1.02
Hydrophobic TM5 L 290 5x61 G.H5 L 375 G.H5.20
Polar ICL2 Y 217 - G.H5 F 363 G.H5.08
Aromatic ICL2 Y 217 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 Y 217 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 Y 217 - G.H5 F 363 G.H5.08
Hydrophobic TM5 K 293 5x64 G.H5 L 371 G.H5.16
Van-der-waals TM5 K 293 5x64 G.H5 L 371 G.H5.16
Hydrophobic TM7 F 358 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 358 7x56 G.H5 L 380 G.H5.25
Polar ICL2 E 220 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 E 220 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 E 220 - G.hns1 R 56 G.hns1.03
Hydrophobic TM7 Y 359 7x57 G.H5 L 380 G.H5.25
Polar C-term T 395 - G.H2 Q 240 G.H2.09
Van-der-waals C-term T 395 - G.H2 Q 240 G.H2.09
Hydrophobic TM5 I 289 5x60 G.H5 L 371 G.H5.16
Polar TM3 V 214 3x59 G.H5 K 367 G.H5.12
Hydrophobic ICL2 Y 217 - G.H5 I 370 G.H5.15
Polar ICL2 T 216 - G.H5 K 367 G.H5.12
Hydrophobic ICL2 T 216 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 T 216 - G.H5 K 367 G.H5.12
Hydrophobic C-term I 393 - G.H3 K 284 G.H3.16
Hydrophobic TM5 K 293 5x64 G.H5 L 375 G.H5.20
Polar ICL2 R 221 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 221 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 221 - G.hns1 R 56 G.hns1.03
Hydrophobic TM6 V 314 6x44 G.H5 L 380 G.H5.25
Polar ICL2 Y 217 - G.H5 K 367 G.H5.12
Hydrophobic ICL2 Y 217 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 Y 217 - G.H5 K 367 G.H5.12
Polar TM3 A 212 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 212 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 L 209 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 209 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 Y 217 - G.H5 V 366 G.H5.11
Van-der-waals ICL2 Y 217 - G.H5 V 366 G.H5.11
Polar ICL2 R 221 - G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 R 221 - G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 Y 217 - G.S1 V 58 G.S1.02