Gs - CRF2 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 T 216 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 T 216 - G.H5 I 383 G.H5.15
Polar ICL2 Y 217 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 Y 217 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 Y 217 - G.H5 R 380 G.H5.12
Hydrophobic TM5 L 290 5x61 G.H5 L 388 G.H5.20
Polar TM5 K 293 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 293 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 293 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 213 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 213 3x58 G.H5 L 388 G.H5.20
Hydrophobic C-term V 411 - G.s4h3 D 260 G.s4h3.11
Hydrophobic TM6 A 311 6x41 G.H5 L 393 G.H5.25
Aromatic TM2 R 148 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 148 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 148 2x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 Y 217 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 Y 217 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 T 216 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 Y 217 - G.H5 I 383 G.H5.15
Polar TM4 R 223 4x42 G.HN Q 35 G.HN.52
Van-der-waals TM4 R 223 4x42 G.HN Q 35 G.HN.52
Hydrophobic TM2 H 152 2x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 290 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM7 F 362 7x60 G.H5 E 392 G.H5.24
Van-der-waals TM7 F 362 7x60 G.H5 E 392 G.H5.24
Hydrophobic TM3 Y 208 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 208 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 318 6x48 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 E 220 - G.hns1 A 39 G.hns1.03
Polar C-term H 403 - G.H3 R 280 G.H3.16
Aromatic C-term H 403 - G.H3 R 280 G.H3.16
Hydrophobic C-term H 403 - G.H3 R 280 G.H3.16
Van-der-waals C-term H 403 - G.H3 R 280 G.H3.16
Hydrophobic TM7 Y 359 7x57 G.H5 Y 391 G.H5.23
Ionic TM5 K 293 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 293 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 293 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 293 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM3 L 209 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 209 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 A 212 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 212 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM6 L 315 6x45 G.H5 L 393 G.H5.25
Hydrophobic ICL2 Y 217 - G.S3 F 219 G.S3.03
Aromatic ICL2 Y 217 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 Y 217 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 Y 217 - G.S1 H 41 G.S1.02
Polar H8 N 363 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 N 363 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 363 8x47 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 307 6x37 G.H5 L 394 G.H5.26
Polar H8 G 364 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 G 364 8x48 G.H5 E 392 G.H5.24
Polar ICL2 T 216 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 T 216 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 T 216 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 T 216 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 217 - G.H5 C 379 G.H5.11
Van-der-waals ICL2 Y 217 - G.H5 C 379 G.H5.11
Hydrophobic TM5 L 294 5x65 G.H5 L 394 G.H5.26
Polar TM2 R 148 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 148 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 148 2x46 G.H5 Q 390 G.H5.22
Polar ICL2 Y 217 - G.H5 F 376 G.H5.08
Aromatic ICL2 Y 217 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 Y 217 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 Y 217 - G.H5 F 376 G.H5.08
Polar TM3 I 213 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 213 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 213 3x58 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 T 219 - G.H5 H 387 G.H5.19
Hydrophobic TM5 K 293 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 E 220 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 220 - G.hns1 R 38 G.hns1.02