G12 - D1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 133 34x55 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 R 133 34x55 G.s2s3 K 220 G.s2s3.02
Ionic TM5 R 227 5x71 G.H5 D 368 G.H5.13
Polar TM5 R 227 5x71 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 227 5x71 G.H5 D 368 G.H5.13
Hydrophobic TM2 V 58 2x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 V 58 2x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 A 221 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 A 221 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 F 129 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 129 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM7 I 330 7x52 G.H5 L 380 G.H5.25
Van-der-waals TM7 I 330 7x52 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 128 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 128 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM7 F 333 7x55 G.H5 L 380 G.H5.25
Polar TM5 A 238 5x82 G.H4 Q 333 G.H4.13
Hydrophobic TM5 A 238 5x82 G.H4 Q 333 G.H4.13
Van-der-waals TM5 A 238 5x82 G.H4 Q 333 G.H4.13
Hydrophobic ICL2 F 129 34x51 G.H5 K 367 G.H5.12
Hydrophobic C-term I 358 - G.H3 L 285 G.H3.17
Polar H8 R 338 8x51 G.H5 L 380 G.H5.25
Van-der-waals H8 R 338 8x51 G.H5 L 380 G.H5.25
Polar C-term L 387 - G.S6 L 346 G.S6.01
Hydrophobic TM5 K 239 5x83 G.H4 Q 333 G.H4.13
Hydrophobic TM6 V 270 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 270 6x33 G.H5 M 379 G.H5.24
Hydrophobic C-term V 388 - G.S6 H 348 G.S6.03
Polar ICL1 S 56 12x52 G.hns1 R 55 G.hns1.02
Hydrophobic C-term I 363 - G.H3 T 279 G.H3.11
Van-der-waals C-term I 363 - G.H3 T 279 G.H3.11
Hydrophobic TM3 I 125 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 125 3x54 G.H5 L 375 G.H5.20
Polar C-term N 386 - G.h4s6 R 342 G.h4s6.11
Hydrophobic C-term N 386 - G.h4s6 R 342 G.h4s6.11
Van-der-waals C-term N 386 - G.h4s6 R 342 G.h4s6.11
Polar TM5 Q 242 5x86 G.hgh4 R 318 G.hgh4.06
Hydrophobic TM5 Q 242 5x86 G.hgh4 R 318 G.hgh4.06
Van-der-waals TM5 Q 242 5x86 G.hgh4 R 318 G.hgh4.06
Polar TM5 Q 242 5x86 G.H4 R 337 G.H4.17
Van-der-waals TM5 Q 242 5x86 G.H4 R 337 G.H4.17
Hydrophobic C-term V 388 - G.H4 D 336 G.H4.16
Van-der-waals C-term V 388 - G.H4 D 336 G.H4.16
Hydrophobic ICL2 F 129 34x51 G.H5 V 366 G.H5.11
Polar TM5 Q 224 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 Q 224 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 Q 224 5x68 G.H5 D 368 G.H5.13
Polar C-term L 387 - G.h4s6 R 339 G.h4s6.08
Hydrophobic C-term Y 389 - G.h4s6 P 345 G.h4s6.20
Van-der-waals C-term Y 389 - G.h4s6 P 345 G.h4s6.20
Ionic TM2 K 57 2x37 G.H5 D 377 G.H5.22
Polar TM2 K 57 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 K 57 2x37 G.H5 D 377 G.H5.22
Hydrophobic H8 N 334 8x47 G.H5 L 380 G.H5.25
Polar TM5 Q 242 5x86 G.H4 Q 333 G.H4.13
Hydrophobic TM5 Q 242 5x86 G.H4 Q 333 G.H4.13
Hydrophobic TM3 I 125 3x54 G.H5 N 374 G.H5.19
Hydrophobic TM5 A 238 5x82 G.H4 R 329 G.H4.09
Van-der-waals TM5 A 238 5x82 G.H4 R 329 G.H4.09
Hydrophobic TM6 T 273 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 273 6x36 G.H5 M 379 G.H5.24
Hydrophobic C-term V 388 - G.S6 L 346 G.S6.01
Hydrophobic ICL2 E 132 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM5 Q 224 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM5 Q 224 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM5 Q 224 5x68 G.H5 L 375 G.H5.20
Hydrophobic TM3 R 121 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 I 378 G.H5.23
Polar ICL2 R 133 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 133 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 133 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic C-term Y 389 - G.S6 F 347 G.S6.02
Polar C-term Y 389 - G.S6 L 346 G.S6.01
Hydrophobic C-term Y 389 - G.S6 L 346 G.S6.01
Van-der-waals C-term Y 389 - G.S6 L 346 G.S6.01
Hydrophobic TM5 I 228 5x72 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 F 129 34x51 G.S1 V 58 G.S1.02
Hydrophobic C-term I 391 - G.S6 F 347 G.S6.02
Hydrophobic TM3 I 125 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 125 3x54 G.H5 I 378 G.H5.23
Polar C-term H 393 - G.S6 F 350 G.S6.05
Hydrophobic C-term I 358 - G.H3 K 284 G.H3.16
Ionic C-term E 359 - G.H3 K 284 G.H3.16
Polar C-term E 359 - G.H3 K 284 G.H3.16
Hydrophobic C-term E 359 - G.H3 K 284 G.H3.16
Van-der-waals C-term E 359 - G.H3 K 284 G.H3.16
Polar C-term L 390 - G.S6 H 348 G.S6.03
Hydrophobic C-term L 390 - G.S6 H 348 G.S6.03
Van-der-waals C-term L 390 - G.S6 H 348 G.S6.03
Polar C-term Y 389 - G.S6 H 348 G.S6.03
Hydrophobic C-term Y 389 - G.S6 H 348 G.S6.03
Van-der-waals C-term Y 389 - G.S6 H 348 G.S6.03
Hydrophobic C-term C 385 - G.h4s6 R 342 G.h4s6.11
Hydrophobic C-term H 393 - G.S6 H 349 G.S6.04
Hydrophobic C-term I 391 - G.H5 F 361 G.H5.06
Van-der-waals C-term I 391 - G.H5 F 361 G.H5.06
Hydrophobic ICL2 P 128 34x50 G.H5 L 371 G.H5.16
Polar C-term N 355 - G.H3 K 284 G.H3.16
Hydrophobic TM3 I 125 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 125 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM6 K 269 6x32 G.H5 M 379 G.H5.24
Hydrophobic ICL2 F 129 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 129 34x51 G.H5 I 370 G.H5.15
Hydrophobic C-term V 388 - G.H4 V 332 G.H4.12
Polar TM3 A 124 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 N 374 G.H5.19
Aromatic ICL2 F 129 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 129 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 129 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 P 128 34x50 G.H5 K 367 G.H5.12
Polar C-term A 357 - G.H3 K 284 G.H3.16
Van-der-waals C-term A 357 - G.H3 K 284 G.H3.16
Hydrophobic TM5 I 220 5x64 G.H5 L 371 G.H5.16
Polar TM6 K 269 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 269 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 269 6x32 G.H5 Q 381 G.H5.26