G15 - FZD10 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 74.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 28.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 K 341 - G.H5 L 364 G.H5.16
Hydrophobic TM2 E 260 2x41 G.H5 I 371 G.H5.23
Van-der-waals TM2 E 260 2x41 G.H5 I 371 G.H5.23
Hydrophobic ICL3 L 437 - G.H5 L 368 G.H5.20
Van-der-waals ICL3 L 437 - G.H5 L 368 G.H5.20
Hydrophobic C-term V 581 - G.h1ha G 67 G.h1ha.01
Hydrophobic N-term P 73 - G.s2s3 K 201 G.s2s3.02
Van-der-waals N-term P 73 - G.s2s3 K 201 G.s2s3.02
Polar C-term V 581 - G.S2 C 196 G.S2.05
Van-der-waals C-term V 581 - G.h1ha A 68 G.h1ha.02
Hydrophobic ICL3 K 436 - G.H5 L 373 G.H5.25
Van-der-waals ICL3 K 436 - G.H5 L 373 G.H5.25
Polar TM6 R 443 6x32 G.H5 I 371 G.H5.23
Ionic TM4 E 345 4x36 G.HN K 36 G.HN.51
Polar TM4 E 345 4x36 G.HN K 36 G.HN.51
Hydrophobic TM4 E 345 4x36 G.HN K 36 G.HN.51
Van-der-waals TM4 E 345 4x36 G.HN K 36 G.HN.51
Hydrophobic C-term V 581 - G.S2 Y 195 G.S2.04
Hydrophobic TM4 A 346 4x37 G.hns1 R 40 G.hns1.02
Van-der-waals TM4 A 346 4x37 G.hns1 R 40 G.hns1.02
Hydrophobic C-term C 580 - G.S2 C 196 G.S2.05
Van-der-waals C-term C 580 - G.S2 C 196 G.S2.05
Ionic TM4 E 348 4x39 G.hns1 R 40 G.hns1.02
Polar TM4 E 348 4x39 G.hns1 R 40 G.hns1.02
Hydrophobic TM4 E 348 4x39 G.hns1 R 40 G.hns1.02
Van-der-waals TM4 E 348 4x39 G.hns1 R 40 G.hns1.02
Hydrophobic TM6 L 440 6x29 G.H5 L 373 G.H5.25
Van-der-waals TM6 L 440 6x29 G.H5 L 373 G.H5.25
Polar ICL2 K 341 - G.H5 R 360 G.H5.12
Hydrophobic ICL2 K 341 - G.H5 R 360 G.H5.12
Van-der-waals ICL2 K 341 - G.H5 R 360 G.H5.12
Hydrophobic TM5 V 426 5x75 G.H5 K 357 G.H5.09
Hydrophobic TM6 K 439 6x28 G.H5 L 373 G.H5.25
Ionic TM4 H 344 4x35 G.H5 E 370 G.H5.22
Polar TM4 H 344 4x35 G.H5 E 370 G.H5.22
Hydrophobic TM4 H 344 4x35 G.H5 E 370 G.H5.22
Van-der-waals TM4 H 344 4x35 G.H5 E 370 G.H5.22
Polar H8 K 526 8x49 G.H5 N 372 G.H5.24
Van-der-waals H8 K 526 8x49 G.H5 N 372 G.H5.24
Hydrophobic C-term P 578 - G.S3 R 205 G.S3.04
Van-der-waals C-term P 578 - G.S3 R 205 G.S3.04
Hydrophobic TM3 A 337 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 A 337 3x53 G.H5 Y 367 G.H5.19
Hydrophobic TM4 I 347 4x38 G.H5 Y 367 G.H5.19
Van-der-waals TM4 I 347 4x38 G.H5 Y 367 G.H5.19
Hydrophobic TM4 G 343 4x34 G.H5 Y 367 G.H5.19
Van-der-waals TM4 G 343 4x34 G.H5 Y 367 G.H5.19
Hydrophobic TM4 G 343 4x34 G.H5 V 363 G.H5.15
Polar C-term T 579 - G.S2 E 194 G.S2.03
Van-der-waals C-term T 579 - G.S2 E 194 G.S2.03
Polar TM2 Y 258 2x39 G.H5 Y 367 G.H5.19
Hydrophobic TM2 Y 258 2x39 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 W 342 - G.H5 V 363 G.H5.15
Hydrophobic ICL3 K 436 - G.h4s6 R 335 G.h4s6.17
Van-der-waals ICL3 K 436 - G.h4s6 R 335 G.h4s6.17
Hydrophobic TM5 M 427 5x76 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM5 M 427 5x76 G.h4s6 R 338 G.h4s6.20
Hydrophobic C-term P 578 - G.S2 E 194 G.S2.03
Van-der-waals C-term P 578 - G.S2 E 194 G.S2.03
Hydrophobic C-term V 581 - G.H1 R 63 G.H1.09
Van-der-waals C-term V 581 - G.H1 R 63 G.H1.09
Hydrophobic TM2 P 259 2x40 G.H5 I 371 G.H5.23
Van-der-waals TM2 P 259 2x40 G.H5 I 371 G.H5.23
Hydrophobic TM5 L 420 5x69 G.H5 L 368 G.H5.20
Polar TM4 E 345 4x36 G.hns1 R 40 G.hns1.02
Hydrophobic TM4 E 345 4x36 G.hns1 R 40 G.hns1.02
Van-der-waals TM4 E 345 4x36 G.hns1 R 40 G.hns1.02
Hydrophobic TM3 A 338 3x54 G.H5 L 364 G.H5.16
Hydrophobic ICL3 K 436 - G.H5 L 374 G.H5.26
Van-der-waals ICL3 K 436 - G.H5 L 374 G.H5.26
Hydrophobic TM6 L 440 6x29 G.H5 L 368 G.H5.20
Van-der-waals TM6 L 440 6x29 G.H5 L 368 G.H5.20
Hydrophobic ICL2 W 342 - G.H5 Y 367 G.H5.19
Van-der-waals ICL2 W 342 - G.H5 Y 367 G.H5.19
Hydrophobic TM4 H 344 4x35 G.H5 Y 367 G.H5.19
Van-der-waals TM4 H 344 4x35 G.H5 Y 367 G.H5.19
Hydrophobic TM5 I 423 5x72 G.H5 L 364 G.H5.16
Van-der-waals TM5 I 423 5x72 G.H5 L 364 G.H5.16
Hydrophobic TM4 A 349 4x40 G.HN K 37 G.HN.52
Polar TM3 T 333 3x49 G.H5 Y 367 G.H5.19
Polar N-term A 72 - G.s2s3 K 201 G.s2s3.02
Hydrophobic N-term A 72 - G.s2s3 K 201 G.s2s3.02
Van-der-waals N-term A 72 - G.s2s3 K 201 G.s2s3.02
Hydrophobic ICL2 K 341 - G.H5 V 363 G.H5.15
Van-der-waals ICL2 K 341 - G.H5 V 363 G.H5.15
Ionic ICL2 K 341 - G.H5 D 361 G.H5.13
Polar ICL2 K 341 - G.H5 D 361 G.H5.13
Van-der-waals ICL2 K 341 - G.H5 D 361 G.H5.13
Polar TM4 Y 353 4x44 G.HN K 37 G.HN.52
Ionic ICL3 E 432 - G.h4s6 R 338 G.h4s6.20
Polar ICL3 E 432 - G.h4s6 R 338 G.h4s6.20
Hydrophobic ICL3 E 432 - G.h4s6 R 338 G.h4s6.20
Van-der-waals ICL3 E 432 - G.h4s6 R 338 G.h4s6.20
Hydrophobic TM7 W 521 7x55 G.H5 I 371 G.H5.23
Ionic N-term E 76 - G.s2s3 K 201 G.s2s3.02
Polar N-term E 76 - G.s2s3 K 201 G.s2s3.02
Hydrophobic N-term E 76 - G.s2s3 K 201 G.s2s3.02
Van-der-waals N-term E 76 - G.s2s3 K 201 G.s2s3.02
Polar TM2 P 259 2x40 G.H5 Y 367 G.H5.19
Hydrophobic TM2 P 259 2x40 G.H5 Y 367 G.H5.19
Van-der-waals TM2 P 259 2x40 G.H5 Y 367 G.H5.19
Aromatic N-term H 69 - G.s2s3 K 201 G.s2s3.02
Hydrophobic N-term H 69 - G.s2s3 K 201 G.s2s3.02
Van-der-waals N-term H 69 - G.s2s3 K 201 G.s2s3.02
Hydrophobic TM4 A 349 4x40 G.hns1 R 40 G.hns1.02
Van-der-waals TM4 A 349 4x40 G.hns1 R 40 G.hns1.02
Hydrophobic TM6 L 440 6x29 G.H5 I 371 G.H5.23
Van-der-waals TM6 L 440 6x29 G.H5 I 371 G.H5.23
Polar N-term Q 123 - G.HN K 37 G.HN.52