Ggust - FZD3 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 73.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 23.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 W 319 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 W 319 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 W 319 - G.H5 C 351 G.H5.23
Polar TM4 S 321 4x35 G.H5 C 351 G.H5.23
Hydrophobic TM4 S 321 4x35 G.H5 C 351 G.H5.23
Van-der-waals TM4 S 321 4x35 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 397 5x69 G.H5 L 348 G.H5.20
Hydrophobic TM6 N 410 6x22 G.H5 F 354 G.H5.26
Van-der-waals TM6 N 410 6x22 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 404 5x76 G.H5 D 341 G.H5.13
Van-der-waals TM5 I 404 5x76 G.H5 D 341 G.H5.13
Hydrophobic C-term L 537 - G.H2 R 205 G.H2.01
Van-der-waals C-term L 537 - G.H2 R 205 G.H2.01
Hydrophobic ICL2 W 319 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 W 319 - G.hns1 R 32 G.hns1.03
Hydrophobic C-term G 550 - G.s4h3 E 238 G.s4h3.12
Van-der-waals C-term G 550 - G.s4h3 E 238 G.s4h3.12
Van-der-waals TM2 Y 233 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM4 A 323 4x37 G.hns1 A 31 G.hns1.02
Van-der-waals TM4 A 323 4x37 G.hns1 A 31 G.hns1.02
Aromatic C-term F 532 - G.H3 H 256 G.H3.15
Hydrophobic C-term F 532 - G.H3 H 256 G.H3.15
Van-der-waals C-term F 532 - G.H3 H 256 G.H3.15
Hydrophobic ICL3 L 406 - G.H5 K 345 G.H5.17
Polar C-term S 552 - G.s4h3 E 238 G.s4h3.12
Hydrophobic C-term S 552 - G.s4h3 E 238 G.s4h3.12
Van-der-waals C-term S 552 - G.s4h3 E 238 G.s4h3.12
Hydrophobic TM6 K 413 6x25 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 413 6x25 G.H5 F 354 G.H5.26
Hydrophobic TM3 W 311 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 W 311 3x50 G.H5 L 353 G.H5.25
Polar C-term T 551 - H.HD E 145 H.HD.12
Hydrophobic TM6 L 414 6x26 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 414 6x26 G.H5 F 354 G.H5.26
Hydrophobic TM4 I 324 4x38 G.H5 C 351 G.H5.23
Van-der-waals TM4 I 324 4x38 G.H5 C 351 G.H5.23
Hydrophobic TM6 F 417 6x29 G.H5 G 352 G.H5.24
Van-der-waals TM6 F 417 6x29 G.H5 G 352 G.H5.24
Hydrophobic C-term I 544 - G.s4h3 V 240 G.s4h3.14
Van-der-waals C-term I 544 - G.s4h3 V 240 G.s4h3.14
Hydrophobic ICL2 P 317 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 397 5x69 G.H5 L 353 G.H5.25
Van-der-waals TM5 L 397 5x69 G.H5 L 353 G.H5.25
Hydrophobic C-term S 548 - G.s4h3 V 233 G.s4h3.07
Van-der-waals C-term S 548 - G.s4h3 V 233 G.s4h3.07
Hydrophobic TM4 G 320 4x34 G.H5 N 347 G.H5.19
Van-der-waals TM4 G 320 4x34 G.H5 N 347 G.H5.19
Polar ICL2 K 318 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 K 318 - G.H5 N 347 G.H5.19
Polar C-term R 538 - G.H3 H 248 G.H3.07
Aromatic C-term R 538 - G.H3 H 248 G.H3.07
Hydrophobic C-term R 538 - G.H3 H 248 G.H3.07
Van-der-waals C-term R 538 - G.H3 H 248 G.H3.07
Hydrophobic C-term G 550 - G.s4h3 V 233 G.s4h3.07
Hydrophobic TM2 P 234 2x40 G.H5 C 351 G.H5.23
Van-der-waals TM2 P 234 2x40 G.H5 C 351 G.H5.23
Aromatic C-term F 532 - G.h2s4 F 215 G.h2s4.01
Hydrophobic C-term F 532 - G.h2s4 F 215 G.h2s4.01
Van-der-waals C-term F 532 - G.h2s4 F 215 G.h2s4.01
Polar C-term L 536 - G.H2 R 208 G.H2.04
Hydrophobic C-term L 536 - G.H2 R 208 G.H2.04
Van-der-waals C-term L 536 - G.H2 R 208 G.H2.04
Hydrophobic ICL2 W 319 - G.HN E 28 G.HN.52
Hydrophobic TM3 A 314 3x53 G.H5 L 353 G.H5.25
Van-der-waals TM3 A 314 3x53 G.H5 L 353 G.H5.25
Hydrophobic C-term T 551 - H.HA T 90 H.HA.28
Ionic C-term E 529 - G.H3 K 257 G.H3.16
Polar C-term E 529 - G.H3 K 257 G.H3.16
Van-der-waals C-term E 529 - G.H3 K 257 G.H3.16
Hydrophobic C-term L 536 - G.H3 L 249 G.H3.08
Van-der-waals C-term L 536 - G.H3 L 249 G.H3.08
Hydrophobic TM6 F 417 6x29 G.H5 F 354 G.H5.26
Hydrophobic C-term L 537 - G.H2 K 209 G.H2.05
Van-der-waals C-term L 537 - G.H2 K 209 G.H2.05
Polar TM6 N 410 6x22 G.H5 K 345 G.H5.17
Hydrophobic TM6 N 410 6x22 G.H5 K 345 G.H5.17
Van-der-waals TM6 N 410 6x22 G.H5 K 345 G.H5.17
Hydrophobic C-term F 532 - G.H2 I 212 G.H2.08
Polar ICL1 R 232 12x51 G.h3s5 T 261 G.h3s5.02
Hydrophobic ICL1 R 232 12x51 G.h3s5 T 261 G.h3s5.02
Van-der-waals ICL1 R 232 12x51 G.h3s5 T 261 G.h3s5.02
Ionic C-term R 546 - G.s4h3 E 239 G.s4h3.13
Polar C-term R 546 - G.s4h3 E 239 G.s4h3.13
Hydrophobic C-term R 546 - G.s4h3 E 239 G.s4h3.13
Van-der-waals C-term R 546 - G.s4h3 E 239 G.s4h3.13
Hydrophobic TM3 A 315 3x54 G.H5 L 348 G.H5.20
Polar TM2 Y 233 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 Y 233 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 Y 233 2x39 G.H5 C 351 G.H5.23
Ionic TM4 K 326 4x40 G.hns1 D 30 G.hns1.01
Polar TM4 K 326 4x40 G.hns1 D 30 G.hns1.01
Van-der-waals TM4 K 326 4x40 G.hns1 D 30 G.hns1.01
Hydrophobic ICL2 K 318 - G.S3 L 194 G.S3.01
Polar ICL2 W 319 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 W 319 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 W 319 - G.hns1 A 31 G.hns1.02
Hydrophobic C-term L 537 - G.H2 S 206 G.H2.02
Hydrophobic TM3 A 314 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 314 3x53 G.H5 C 351 G.H5.23
Polar TM4 S 321 4x35 G.H5 D 350 G.H5.22
Hydrophobic TM4 S 321 4x35 G.H5 D 350 G.H5.22
Van-der-waals TM4 S 321 4x35 G.H5 D 350 G.H5.22
Van-der-waals C-term S 548 - G.s4h3 E 238 G.s4h3.12
Hydrophobic TM4 K 327 4x41 G.HN A 27 G.HN.51
Van-der-waals TM4 K 327 4x41 G.HN A 27 G.HN.51
Polar C-term T 553 - H.HA K 86 H.HA.24
Hydrophobic C-term T 553 - H.HA K 86 H.HA.24
Van-der-waals C-term T 553 - H.HA K 86 H.HA.24
Polar C-term T 551 - G.s4h3 E 238 G.s4h3.12
Hydrophobic C-term T 551 - G.s4h3 E 238 G.s4h3.12
Van-der-waals C-term T 551 - G.s4h3 E 238 G.s4h3.12
Hydrophobic C-term L 536 - G.H2 W 211 G.H2.07
Van-der-waals C-term L 536 - G.H2 W 211 G.H2.07
Hydrophobic ICL3 L 406 - G.H5 F 354 G.H5.26
Hydrophobic TM3 A 314 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 A 314 3x53 G.H5 L 348 G.H5.20
Hydrophobic ICL2 W 319 - G.H5 N 347 G.H5.19
Hydrophobic TM4 E 322 4x36 G.h2s4 G 217 G.h2s4.03
Van-der-waals TM4 E 322 4x36 G.h2s4 G 217 G.h2s4.03
Polar TM4 G 320 4x34 G.H5 C 351 G.H5.23
Hydrophobic TM4 G 320 4x34 G.H5 C 351 G.H5.23
Van-der-waals TM4 G 320 4x34 G.H5 C 351 G.H5.23
Polar C-term S 535 - G.H3 S 252 G.H3.11
Ionic ICL1 R 232 12x51 G.H5 D 350 G.H5.22
Polar ICL1 R 232 12x51 G.H5 D 350 G.H5.22
Hydrophobic TM6 F 417 6x29 G.H5 L 353 G.H5.25
Van-der-waals TM6 F 417 6x29 G.H5 L 353 G.H5.25
Hydrophobic ICL2 K 318 - G.H5 I 344 G.H5.16
Hydrophobic C-term A 533 - G.H2 K 209 G.H2.05
Hydrophobic TM5 I 404 5x76 G.H5 I 344 G.H5.16
Hydrophobic TM2 E 235 2x41 G.H5 G 352 G.H5.24
Van-der-waals TM2 E 235 2x41 G.H5 G 352 G.H5.24