Gz - GPR39 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 249 5x68 G.H5 L 349 G.H5.20
Hydrophobic C-term V 376 - G.h3s5 I 261 G.h3s5.01
Polar ICL3 S 269 - G.S6 I 320 G.S6.01
Van-der-waals ICL3 S 269 - G.S6 I 320 G.S6.01
Polar ICL2 S 147 34x57 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 S 147 34x57 G.hns1 R 31 G.hns1.02
Hydrophobic TM2 V 68 2x39 G.H5 I 352 G.H5.23
Polar TM6 S 274 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 S 274 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 S 274 6x26 G.h4s6 E 319 G.h4s6.12
Ionic ICL3 K 268 - G.h4s6 E 319 G.h4s6.12
Polar ICL3 K 268 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 K 268 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 K 268 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 R 133 3x50 G.H5 L 354 G.H5.25
Ionic ICL3 K 268 - G.H5 D 342 G.H5.13
Polar ICL3 K 268 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 K 268 - G.H5 D 342 G.H5.13
Polar ICL2 K 144 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 K 144 34x54 G.S1 E 33 G.S1.01
Hydrophobic TM6 S 271 6x23 G.h4s6 T 317 G.h4s6.10
Polar TM5 S 252 5x71 G.H5 D 342 G.H5.13
Hydrophobic TM5 S 252 5x71 G.H5 D 342 G.H5.13
Van-der-waals TM5 S 252 5x71 G.H5 D 342 G.H5.13
Polar TM3 R 133 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM6 T 281 6x33 G.H5 L 349 G.H5.20
Hydrophobic TM3 A 136 3x53 G.H5 I 352 G.H5.23
Van-der-waals TM3 A 136 3x53 G.H5 I 352 G.H5.23
Hydrophobic ICL2 P 140 34x50 G.H5 T 341 G.H5.12
Polar H8 S 348 8x47 G.H5 C 355 G.H5.26
Hydrophobic H8 S 348 8x47 G.H5 C 355 G.H5.26
Van-der-waals H8 S 348 8x47 G.H5 C 355 G.H5.26
Hydrophobic ICL2 F 141 34x51 G.S1 I 34 G.S1.02
Van-der-waals ICL2 F 141 34x51 G.S1 I 34 G.S1.02
Hydrophobic TM3 I 137 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 137 3x54 G.H5 L 349 G.H5.20
Polar TM7 S 347 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 S 347 7x56 G.H5 G 353 G.H5.24
Hydrophobic TM6 F 284 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 F 284 6x36 G.H5 L 354 G.H5.25
Hydrophobic ICL3 L 266 - G.H5 F 335 G.H5.06
Van-der-waals ICL3 L 266 - G.H5 F 335 G.H5.06
Polar C-term S 396 - G.s4h3 Q 240 G.s4h3.13
Van-der-waals C-term S 396 - G.s4h3 Q 240 G.s4h3.13
Polar TM6 S 271 6x23 G.h4s6 E 316 G.h4s6.09
Hydrophobic TM6 S 271 6x23 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 S 271 6x23 G.h4s6 E 316 G.h4s6.09
Hydrophobic TM6 A 277 6x29 G.H5 C 355 G.H5.26
Hydrophobic ICL1 L 64 - G.H5 Y 351 G.H5.22
Hydrophobic ICL2 F 141 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 F 141 34x51 G.H5 I 344 G.H5.15
Polar ICL3 R 267 - G.H4 Q 305 G.H4.12
Hydrophobic ICL3 R 267 - G.H4 Q 305 G.H4.12
Van-der-waals ICL3 R 267 - G.H4 Q 305 G.H4.12
Polar TM6 S 274 6x26 G.H5 Q 346 G.H5.17
Van-der-waals TM6 S 274 6x26 G.H5 Q 346 G.H5.17
Polar ICL3 K 268 - G.H5 Q 346 G.H5.17
Van-der-waals ICL3 K 268 - G.H5 Q 346 G.H5.17
Polar ICL1 Q 65 - G.H5 Y 351 G.H5.22
Hydrophobic ICL1 Q 65 - G.H5 Y 351 G.H5.22
Van-der-waals ICL1 Q 65 - G.H5 Y 351 G.H5.22
Polar C-term K 372 - G.H3 W 259 G.H3.17
Van-der-waals C-term K 372 - G.H3 W 259 G.H3.17
Hydrophobic TM3 I 137 3x54 G.H5 L 354 G.H5.25
Polar TM6 E 273 6x25 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 E 273 6x25 G.h4s6 E 316 G.h4s6.09
Hydrophobic ICL3 S 269 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 S 269 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 Y 143 34x53 G.H5 I 352 G.H5.23
Polar H8 Q 349 8x48 G.H5 C 355 G.H5.26
Van-der-waals H8 Q 349 8x48 G.H5 C 355 G.H5.26
Van-der-waals ICL3 K 268 - G.S6 I 320 G.S6.01
Polar TM3 A 136 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 136 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 136 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 Y 143 34x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 P 140 34x50 G.H5 I 344 G.H5.15
Hydrophobic ICL1 L 64 - G.H5 I 352 G.H5.23
Van-der-waals ICL1 L 64 - G.H5 I 352 G.H5.23
Polar ICL3 R 267 - G.S6 S 322 G.S6.03
Van-der-waals ICL3 R 267 - G.S6 S 322 G.S6.03
Hydrophobic H8 S 348 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 S 348 8x47 G.H5 G 353 G.H5.24
Hydrophobic ICL3 E 270 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 F 141 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 141 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 P 140 34x50 G.H5 I 345 G.H5.16
Ionic C-term K 372 - G.h2s4 E 217 G.h2s4.02
Polar C-term K 372 - G.h2s4 E 217 G.h2s4.02
Van-der-waals C-term K 372 - G.h2s4 E 217 G.h2s4.02
Hydrophobic ICL3 L 266 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 L 266 - G.S6 Y 321 G.S6.02
Polar TM7 S 347 7x56 G.H5 C 355 G.H5.26
Polar ICL2 K 144 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 K 144 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 K 144 34x54 G.hns1 R 31 G.hns1.02
Ionic C-term D 383 - G.h4s6 R 313 G.h4s6.03
Polar C-term D 383 - G.h4s6 R 313 G.h4s6.03
Hydrophobic C-term D 383 - G.h4s6 R 313 G.h4s6.03
Van-der-waals C-term D 383 - G.h4s6 R 313 G.h4s6.03
Hydrophobic ICL3 L 266 - G.H5 A 339 G.H5.10
Polar TM6 S 271 6x23 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 S 271 6x23 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 S 271 6x23 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 A 145 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM7 S 347 7x56 G.H5 L 354 G.H5.25
Van-der-waals TM7 S 347 7x56 G.H5 L 354 G.H5.25
Polar TM6 T 281 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 281 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 281 6x33 G.H5 L 354 G.H5.25
Polar ICL3 K 268 - G.S6 Y 321 G.S6.02
Hydrophobic ICL3 K 268 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 K 268 - G.S6 Y 321 G.S6.02
Hydrophobic ICL3 L 266 - G.H5 D 338 G.H5.09
Aromatic ICL2 F 141 34x51 G.H5 F 337 G.H5.08
Hydrophobic ICL2 F 141 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 F 141 34x51 G.H5 F 337 G.H5.08
Hydrophobic ICL2 F 141 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 F 141 34x51 G.H5 T 341 G.H5.12
Van-der-waals TM6 S 271 6x23 G.h4s6 K 315 G.h4s6.08
Hydrophobic ICL1 L 64 - G.H5 G 353 G.H5.24
Hydrophobic C-term V 376 - G.H3 N 258 G.H3.16
Van-der-waals C-term V 376 - G.H3 N 258 G.H3.16
Hydrophobic TM5 V 248 5x67 G.H5 I 345 G.H5.16