Gq - BB2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 10.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 P 245 - G.H5 A 343 G.H5.10
Polar ICL3 E 247 - G.S6 F 328 G.S6.05
Hydrophobic ICL3 E 247 - G.S6 F 328 G.S6.05
Van-der-waals ICL3 E 247 - G.S6 F 328 G.S6.05
Hydrophobic ICL3 V 246 - G.h4s6 I 323 G.h4s6.20
Hydrophobic ICL2 P 145 34x50 G.H5 K 345 G.H5.12
Hydrophobic ICL3 V 246 - G.S6 Y 325 G.S6.02
Van-der-waals ICL3 V 246 - G.S6 Y 325 G.S6.02
Hydrophobic TM6 R 259 6x30 G.H5 Q 350 G.H5.17
Van-der-waals TM6 R 259 6x30 G.H5 Q 350 G.H5.17
Polar TM3 D 137 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 137 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 137 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM6 V 266 6x37 G.H5 L 358 G.H5.25
Polar TM6 Q 255 6x26 G.H5 D 346 G.H5.13
Hydrophobic TM2 P 75 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM2 P 75 2x39 G.H5 E 355 G.H5.22
Hydrophobic C-term F 371 - G.H3 Y 261 G.H3.15
Van-der-waals C-term F 371 - G.H3 Y 261 G.H3.15
Hydrophobic TM7 L 325 7x56 G.H5 L 358 G.H5.25
Hydrophobic ICL2 I 148 34x53 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 I 148 34x53 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 I 148 34x53 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 I 148 34x53 G.hns1 R 38 G.hns1.03
Hydrophobic TM2 P 75 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 P 75 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 142 3x54 G.H5 L 353 G.H5.20
Hydrophobic ICL2 I 148 34x53 G.S3 V 199 G.S3.01
Hydrophobic C-term M 358 - G.H3 W 263 G.H3.17
Van-der-waals C-term M 358 - G.H3 W 263 G.H3.17
Hydrophobic C-term T 356 - G.H3 P 262 G.H3.16
Van-der-waals C-term T 356 - G.H3 P 262 G.H3.16
Hydrophobic C-term M 358 - G.H3 Y 261 G.H3.15
Van-der-waals C-term M 358 - G.H3 Y 261 G.H3.15
Polar TM3 R 138 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 P 145 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 145 34x50 G.H5 I 348 G.H5.15
Hydrophobic TM3 R 138 3x50 G.H5 L 358 G.H5.25
Van-der-waals ICL3 E 247 - G.H4 L 310 G.H4.12
Hydrophobic TM3 I 142 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 142 3x54 G.H5 L 358 G.H5.25
Ionic H8 K 327 8x48 G.h4s6 D 321 G.h4s6.12
Polar H8 K 327 8x48 G.h4s6 D 321 G.h4s6.12
Van-der-waals H8 K 327 8x48 G.h4s6 D 321 G.h4s6.12
Polar H8 S 326 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 S 326 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM6 L 262 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 262 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 Q 255 6x26 G.H5 Q 350 G.H5.17
Hydrophobic TM6 Q 255 6x26 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 Q 255 6x26 G.h4s6 I 323 G.h4s6.20
Hydrophobic ICL2 M 146 34x51 G.S1 L 40 G.S1.02
Hydrophobic C-term L 361 - G.H2 I 217 G.H2.08
Hydrophobic ICL2 M 146 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 M 146 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM3 I 142 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 142 3x54 G.H5 L 349 G.H5.16
Hydrophobic TM5 L 244 5x72 G.H5 D 346 G.H5.13
Van-der-waals TM5 L 244 5x72 G.H5 D 346 G.H5.13
Polar TM3 A 141 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 141 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 141 3x53 G.H5 N 352 G.H5.19
Polar ICL2 Q 149 34x54 G.H5 E 355 G.H5.22
Polar TM5 S 240 5x68 G.H5 D 346 G.H5.13
Van-der-waals TM5 S 240 5x68 G.H5 D 346 G.H5.13
Polar TM7 L 325 7x56 G.H5 V 359 G.H5.26
Hydrophobic TM7 L 325 7x56 G.H5 V 359 G.H5.26
Van-der-waals TM7 L 325 7x56 G.H5 V 359 G.H5.26
Ionic ICL3 E 247 - G.S6 H 327 G.S6.04
Polar ICL3 E 247 - G.S6 H 327 G.S6.04
Hydrophobic ICL3 E 247 - G.S6 H 327 G.S6.04
Van-der-waals ICL3 E 247 - G.S6 H 327 G.S6.04
Hydrophobic TM5 S 240 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 S 240 5x68 G.H5 L 349 G.H5.16
Polar TM2 N 76 2x40 G.H5 N 357 G.H5.24
Van-der-waals TM2 N 76 2x40 G.H5 N 357 G.H5.24
Hydrophobic TM5 L 237 5x65 G.H5 L 353 G.H5.20
Hydrophobic TM7 L 322 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 L 322 7x53 G.H5 N 357 G.H5.24
Polar ICL3 E 247 - G.S6 S 326 G.S6.03
Hydrophobic ICL3 E 247 - G.S6 S 326 G.S6.03
Van-der-waals ICL3 E 247 - G.S6 S 326 G.S6.03
Hydrophobic TM6 L 262 6x33 G.H5 L 353 G.H5.20
Hydrophobic ICL2 P 145 34x50 G.H5 L 349 G.H5.16
Polar ICL2 A 150 34x55 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 L 262 6x33 G.H5 V 359 G.H5.26
Hydrophobic ICL2 M 146 34x51 G.H5 K 345 G.H5.12
Polar TM2 N 73 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM2 N 73 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 N 73 2x37 G.H5 E 355 G.H5.22
Hydrophobic C-term M 358 - G.H2 I 217 G.H2.08
Van-der-waals C-term M 358 - G.H2 I 217 G.H2.08
Hydrophobic ICL3 P 245 - G.S6 Y 325 G.S6.02
Van-der-waals ICL3 P 245 - G.S6 Y 325 G.S6.02
Polar H8 K 327 8x48 G.H5 V 359 G.H5.26
Van-der-waals H8 K 327 8x48 G.H5 V 359 G.H5.26
Hydrophobic ICL2 M 146 34x51 G.H5 F 341 G.H5.08
Hydrophobic ICL3 P 245 - G.H5 F 339 G.H5.06
Van-der-waals ICL3 P 245 - G.H5 F 339 G.H5.06
Hydrophobic ICL3 P 245 - G.H5 A 342 G.H5.09
Hydrophobic ICL2 M 146 34x51 G.S3 V 199 G.S3.01
Van-der-waals ICL2 M 146 34x51 G.S3 V 199 G.S3.01
Hydrophobic TM7 L 325 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 L 325 7x56 G.H5 N 357 G.H5.24
Hydrophobic C-term F 371 - G.H3 T 257 G.H3.11
Van-der-waals C-term F 371 - G.H3 T 257 G.H3.11
Hydrophobic TM3 A 141 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 141 3x53 G.H5 Y 356 G.H5.23
Polar H8 S 326 8x47 G.H5 V 359 G.H5.26
Hydrophobic H8 S 326 8x47 G.H5 V 359 G.H5.26
Van-der-waals H8 S 326 8x47 G.H5 V 359 G.H5.26
Hydrophobic C-term L 361 - G.H2 R 214 G.H2.05
Van-der-waals C-term L 361 - G.H2 R 214 G.H2.05
Ionic TM6 R 259 6x30 G.H5 D 346 G.H5.13
Polar TM6 R 259 6x30 G.H5 D 346 G.H5.13
Hydrophobic TM6 R 259 6x30 G.H5 D 346 G.H5.13
Van-der-waals TM6 R 259 6x30 G.H5 D 346 G.H5.13