Gs - H1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 88.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 S 128 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 S 128 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 128 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 I 213 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 213 5x61 G.H5 L 393 G.H5.25
Polar TM3 S 128 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 128 3x53 G.H5 Y 391 G.H5.23
Polar TM3 V 129 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 129 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 129 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM6 R 409 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 409 6x29 G.H5 L 394 G.H5.26
Aromatic TM3 R 125 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 125 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 125 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 132 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM5 V 217 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM5 H 220 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 220 5x68 G.H5 L 388 G.H5.20
Ionic ICL2 R 134 34x52 G.s2s3 D 215 G.s2s3.01
Polar ICL2 R 134 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 134 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 R 134 34x52 G.S3 V 217 G.S3.01
Hydrophobic TM3 V 129 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 133 34x51 G.S3 F 219 G.S3.03
Hydrophobic ICL2 L 136 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic TM6 L 417 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 417 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM3 V 129 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL3 L 231 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 L 231 - G.H4 L 346 G.H4.16
Ionic TM5 H 220 5x68 G.H5 D 381 G.H5.13
Polar TM5 H 220 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 220 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 220 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 V 217 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 217 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL3 P 232 - G.H4 D 343 G.H4.13
Hydrophobic TM6 A 413 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 413 6x33 G.H5 L 393 G.H5.25
Polar ICL2 R 139 34x57 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 K 137 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 P 132 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 132 34x50 G.H5 R 380 G.H5.12
Van-der-waals TM5 L 226 5x74 G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 L 133 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 133 34x51 G.H5 I 383 G.H5.15
Hydrophobic ICL3 L 231 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 L 231 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 V 217 5x65 G.H5 L 394 G.H5.26
Polar TM5 H 220 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 220 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 220 5x68 G.H5 Q 384 G.H5.16
Polar ICL3 S 230 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 S 230 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 S 230 - G.hgh4 D 323 G.hgh4.13
Polar ICL2 L 133 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 133 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 133 34x51 G.S1 H 41 G.S1.02
Polar TM5 H 220 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 220 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 220 5x68 G.H5 R 385 G.H5.17
Hydrophobic ICL2 P 132 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 132 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 I 213 5x61 G.H5 L 388 G.H5.20
Polar ICL3 S 230 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 S 230 - G.H4 R 342 G.H4.12
Hydrophobic ICL2 L 133 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 133 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 L 133 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM5 A 216 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 133 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 136 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 L 136 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 C 221 5x69 G.H5 L 394 G.H5.26
Aromatic ICL2 Y 135 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 135 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 135 34x53 G.H5 H 387 G.H5.19
Polar TM6 K 412 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 412 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 412 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM7 C 471 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 C 471 7x56 G.H5 E 392 G.H5.24
Van-der-waals H8 E 473 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM6 Q 416 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL3 L 231 - G.H4 D 343 G.H4.13
Hydrophobic ICL2 P 132 34x50 G.H5 Q 384 G.H5.16
Ionic TM6 K 412 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 412 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 412 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 412 6x32 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 136 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 136 34x54 G.S1 H 41 G.S1.02
Polar TM5 R 224 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 R 224 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 R 224 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 L 133 34x51 G.H5 C 379 G.H5.11